Pular para o conteúdo
Meningioma
ORPHA:2495CID-10 · D32.9CID-11 · 2A01.0DOENÇA RARA
Esta doença tem causa genética. Recomendamos procurar um médico geneticista para diagnóstico, exames genéticos e aconselhamento familiar.
neuroInício todas idadesHerança Unknown

É um tumor que geralmente cresce lentamente e se prende à dura-máter, uma das membranas que envolvem o cérebro e a medula espinhal. Ele é formado por células anormais que se originam nessas membranas (as meninges). Ocorre principalmente em adultos, sendo mais comum em mulheres, e pode apresentar diversas formas quando analisado ao microscópio. Entre os vários tipos, os mais comuns são os meningiomas meningotelial, fibroso e transicional. A maioria dos meningiomas são tumores de Grau I, segundo a classificação da OMS (Organização Mundial da Saúde), enquanto alguns são de Grau II ou III. A maioria dos tipos tem um comportamento semelhante, mas alguns subtipos têm maior probabilidade de retornar (recidivar) e seguir um curso mais agressivo da doença.

Última verificação: Fonte: sem afirmação sobre o SUS a verificarEm construçãohistóricoSugerir correção
Mantido por Agente Raras·Colaborar como especialista →

Introdução

O que você precisa saber de cara

💬
EM LINGUAGEM SIMPLES

O meningioma é um tipo de tumor que surge a partir das meninges, que são as membranas que envolvem e protegem o cérebro e a medula espinhal. Na maioria dos casos ele cresce devagar e é classificado como Grau I da OMS, podendo causar sintomas como convulsões, alterações na visão ou fraqueza nos membros conforme pressiona áreas cerebrais. Atualmente, esta condição não conta com um Protocolo Clínico e Diretrizes Terapêuticas (PCDT) nem medicamentos específicos dispensados na lista oficial de doenças raras do SUS. A assistência diagnóstica e o cuidado cirúrgico continuam sendo conduzidos pelos serviços especializados da rede de saúde pública do Brasil.

📋
Informacoes curadas por IA — podem conter imprecisoes

É um tumor que geralmente cresce lentamente e se prende à dura-máter, uma das membranas que envolvem o cérebro e a medula espinhal. Ele é formado por células anormais que se originam nessas membranas (as meninges). Ocorre principalmente em adultos, sendo mais comum em mulheres, e pode apresentar diversas formas quando analisado ao microscópio. Entre os vários tipos, os mais comuns são os meningiomas meningotelial, fibroso e transicional. A maioria dos meningiomas são tumores de Grau I, segundo a classificação da OMS (Organização Mundial da Saúde), enquanto alguns são de Grau II ou III. A maioria dos tipos tem um comportamento semelhante, mas alguns subtipos têm maior probabilidade de retornar (recidivar) e seguir um curso mais agressivo da doença.

Pesquisas ativas
97 ensaios
251 total registrados no ClinicalTrials.gov
Publicações científicas
21.953 artigos
Último publicado: 2026 May
Em pesquisa
13 moléculas
MIFEPRISTONE, TRANEXAMIC ACID, OCTREOTIDE

O que está sendo pesquisado

9 moléculas em estudo — nenhuma com registro para esta doença
Ver detalhes e fases →
MIFEPRISTONETRANEXAMIC ACIDOCTREOTIDEIPILIMUMABEVEROLIMUSNIVOLUMABPASIREOTIDELUTETIUM OXODOTREOTIDE LU-177
Aparecer aqui significa que a molécula foi estudada nesta doença, não que trate. Converse com seu médico.

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
Unknown
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Europe
Início
All ages
🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: D32.9
Você se identifica com essa condição?
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Encontrou um erro ou informação desatualizada? Sugira uma correção →

Entender a doença

Do básico ao detalhe, leia no seu ritmo

Preparando trilha educativa...

Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🧠
Neurológico
10 sintomas
📏
Crescimento
9 sintomas
👁️
Olhos
4 sintomas
💪
Músculos
3 sintomas
👂
Ouvidos
2 sintomas
🫁
Pulmão
2 sintomas

+ 40 sintomas em outras categorias

Características mais comuns

90%prev.
Aumento da sensibilidade à radiação ionizante
Muito frequente (99-80%)
90%prev.
Quebra cromossômica induzida por radiação ionizante
Muito frequente (99-80%)
90%prev.
Meningioma intracraniano
Muito frequente (99-80%)
55%prev.
Náusea e vômito
Frequente (79-30%)
55%prev.
Impotência
Frequente (79-30%)
55%prev.
Hipogonadismo hipogonadotrófico
Frequente (79-30%)
76sintomas
Muito frequente (3)
Frequente (19)
Ocasional (32)
Muito raro (20)
Sem dados (2)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 76 características clínicas mais associadas, ordenadas por frequência.

Aumento da sensibilidade à radiação ionizanteIncreased sensitivity to ionizing radiation
Muito frequente (99-80%)90%
Quebra cromossômica induzida por radiação ionizanteChromosomal breakage induced by ionizing radiation
Muito frequente (99-80%)90%
Meningioma intracranianoIntracranial meningioma
Muito frequente (99-80%)90%
Náusea e vômitoNausea and vomiting
Frequente (79-30%)55%
ImpotênciaImpotence
Frequente (79-30%)55%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico21.953PubMed
Últimos 10 anos200publicações
Pico2026184 papers
Linha do tempo
2026Hoje · 2026🧪 1983Primeiro ensaio clínico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

Genes associados

13 genes identificados com associação a esta condição. Padrão de herança: Not applicable.

AKT1RAC-alpha serine/threonine-protein kinaseDisease-causing germline mutation(s) inAltamente restrito
VIAS BIOLÓGICAS (7)
CD28 dependent PI3K/Akt signalingVEGFR2 mediated vascular permeabilityPIP3 activates AKT signalingNegative regulation of the PI3K/AKT networkG beta:gamma signalling through PI3Kgamma
MECANISMO DE DOENÇA

Breast cancer

A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case.

OUTRAS DOENÇAS (7)
ovarian cancerProteus syndromehereditary breast carcinomacolorectal cancer
HGNC:391UniProt:P31749
PTENPhosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENCandidate gene tested inRestrito
VIAS BIOLÓGICAS (10)
Synthesis of PIPs at the plasma membraneDownstream TCR signalingNegative regulation of the PI3K/AKT networkTP53 Regulates Metabolic GenesSynthesis of IP3 and IP4 in the cytosol
MECANISMO DE DOENÇA

Cowden syndrome 1

An autosomal dominant hamartomatous polyposis syndrome with age-related penetrance. Cowden syndrome is characterized by hamartomatous lesions affecting derivatives of ectodermal, mesodermal and endodermal layers, macrocephaly, facial trichilemmomas (benign tumors of the hair follicle infundibulum), acral keratoses, papillomatous papules, and elevated risk for development of several types of malignancy, particularly breast carcinoma in women and thyroid carcinoma in both men and women. Colon cancer and renal cell carcinoma have also been reported. Hamartomas can be found in virtually every organ, but most commonly in the skin, gastrointestinal tract, breast and thyroid.

EXPRESSÃO TECIDUAL(Ubíquo)
Linfócitos
62.5 TPM
Cervix Ectocervix
62.4 TPM
Cervix Endocervix
59.7 TPM
Fallopian Tube
51.0 TPM
Cérebro - Hemisfério cerebelar
49.1 TPM
OUTRAS DOENÇAS (19)
Cowden syndrome 1prostate cancer, hereditaryPTEN hamartoma tumor syndromemacrocephaly-autism syndrome
HGNC:9588UniProt:P60484
MN1Transcriptional activator MN1Disease-causing germline mutation(s) inAltamente restrito
MECANISMO DE DOENÇA

CEBALID syndrome

An autosomal dominant developmental disorder characterized by global developmental delay, intellectual disability with severe expressive language delay, craniofacial dysmorphism, and structural brain abnormalities. Most patients have an atypical form of rhombencephalosynapsis, a distinctive brain malformation characterized by partial or complete loss of the cerebellar vermis with fusion of the cerebellar hemispheres. Other frequent features include perisylvian polymicrogyria, abnormal posterior clinoid processes, cerebellar hypoplasia or dysplasia, and persistent trigeminal artery.

EXPRESSÃO TECIDUAL(Ubíquo)
Artéria tibial
46.4 TPM
Músculo esquelético
35.8 TPM
Aorta
35.1 TPM
Artéria coronária
27.7 TPM
Esôfago - Junção
22.0 TPM
INTERAÇÕES PROTEICAS (2)
OUTRAS DOENÇAS (3)
familial meningiomaCEBALID syndromefamilial multiple meningioma
HGNC:7180UniProt:Q10571
SMARCB1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1Disease-causing germline mutation(s) inAltamente restrito
VIAS BIOLÓGICAS (8)
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownRMTs methylate histone argininesFormation of neuronal progenitor and neuronal BAF (npBAF and nBAF)Formation of the embryonic stem cell BAF (esBAF) complexFormation of the polybromo-BAF (pBAF) complex
MECANISMO DE DOENÇA

Rhabdoid tumor predisposition syndrome 1

A familial cancer syndrome predisposing to renal or extrarenal malignant rhabdoid tumors and to a variety of tumors of the central nervous system, including choroid plexus carcinoma, medulloblastoma, and central primitive neuroectodermal tumors. Rhabdoid tumors are the most aggressive and lethal malignancies occurring in early childhood.

EXPRESSÃO TECIDUAL(Ubíquo)
Linfócitos
136.4 TPM
Testículo
110.5 TPM
Cérebro - Hemisfério cerebelar
98.7 TPM
Cerebelo
93.5 TPM
Ovário
93.2 TPM
OUTRAS DOENÇAS (9)
rhabdoid tumor predisposition syndrome 1intellectual disability, autosomal dominant 15familial multiple meningiomaschwannomatosis
HGNC:11103UniProt:Q12824
TERTTelomerase reverse transcriptaseDisease-causing somatic mutation(s) inRestrito
VIAS BIOLÓGICAS (3)
Telomere Extension By TelomeraseFormation of the beta-catenin:TCF transactivating complexRegulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence
EXPRESSÃO TECIDUAL(Baixa expressão)
Testículo
2.7 TPM
Intestino delgado
0.7 TPM
Brain Caudate basal ganglia
0.6 TPM
Cólon transverso
0.5 TPM
Brain Nucleus accumbens basal ganglia
0.5 TPM
OUTRAS DOENÇAS (13)
dyskeratosis congenita, autosomal dominant 2pulmonary fibrosis and/or bone marrow failure, Telomere-related, 1adrenal cortex carcinomaclear cell sarcoma of kidney
HGNC:11730UniProt:O14746
PDGFBPlatelet-derived growth factor subunit BDisease-causing germline mutation(s) inAltamente restrito
VIAS BIOLÓGICAS (8)
PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingPIP3 activates AKT signalingConstitutive Signaling by Aberrant PI3K in CancerDownstream signal transductionRAF/MAP kinase cascade
MECANISMO DE DOENÇA

Basal ganglia calcification, idiopathic, 5

A form of basal ganglia calcification, an autosomal dominant condition characterized by symmetric calcification in the basal ganglia and other brain regions. Affected individuals can either be asymptomatic or show a wide spectrum of neuropsychiatric symptoms, including parkinsonism, dystonia, tremor, ataxia, dementia, psychosis, seizures, and chronic headache. Serum levels of calcium, phosphate, alkaline phosphatase and parathyroid hormone are normal. The neuropathological hallmark of the disease is vascular and pericapillary calcification, mainly of calcium phosphate, in the affected brain areas.

EXPRESSÃO TECIDUAL(Ubíquo)
Tecido adiposo
49.1 TPM
Pulmão
45.8 TPM
Adipose Visceral Omentum
43.1 TPM
Mama
34.1 TPM
Tireoide
30.5 TPM
OUTRAS DOENÇAS (6)
familial meningiomabasal ganglia calcification, idiopathic, 5familial multiple meningiomameningioma
HGNC:8800UniProt:P01127
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformDisease-causing somatic mutation(s) inAltamente restrito
VIAS BIOLÓGICAS (10)
Signaling by LTK in cancerNephrin family interactionsIRS-mediated signallingTie2 SignalingDAP12 signaling
EXPRESSÃO TECIDUAL(Ubíquo)
Artéria tibial
23.2 TPM
Linfócitos
22.4 TPM
Nervo tibial
21.4 TPM
Tecido adiposo
20.5 TPM
Fibroblastos
20.5 TPM
OUTRAS DOENÇAS (28)
seborrheic keratosismegalodactylyovarian cancerhepatocellular carcinoma
HGNC:8975UniProt:P42336
NF2MerlinDisease-causing somatic mutation(s) inAltamente restrito
VIAS BIOLÓGICAS (2)
Regulation of actin dynamics for phagocytic cup formationRHO GTPases activate PAKs
MECANISMO DE DOENÇA

Schwannomatosis, vestibular

An autosomal dominant neoplasia syndrome characterized by the development of multiple benign nerve sheath tumors called schwannomas, particularly affecting the vestibular nerve. Affected individuals usually present with bilateral vestibular schwannomas but can have schwannomas on other cranial, spinal, and peripheral/cutaneous nerves. Meningiomas are common, whereas 20 to 35% of affected individuals develop intramedullary spinal cord tumors called ependymomas. The condition is also characterized by several ophthalmic features such as lenticular opacities, retinal hamartoma, epiretinal membranes.

EXPRESSÃO TECIDUAL(Ubíquo)
Cerebelo
30.4 TPM
Cérebro - Hemisfério cerebelar
27.6 TPM
Córtex cerebral
25.9 TPM
Fibroblastos
25.9 TPM
Brain Frontal Cortex BA9
24.3 TPM
OUTRAS DOENÇAS (5)
NF2-related schwannomatosisfamilial meningiomamosaic NF2-related schwannomatosismeningioma
HGNC:7773UniProt:P35240
SUFUSuppressor of fused homologDisease-causing germline mutation(s) inAltamente restrito
VIAS BIOLÓGICAS (4)
GLI3 is processed to GLI3R by the proteasomeHedgehog 'off' stateDegradation of GLI1 by the proteasomeDegradation of GLI2 by the proteasome
MECANISMO DE DOENÇA

Medulloblastoma

Malignant, invasive embryonal tumor of the cerebellum with a preferential manifestation in children.

EXPRESSÃO TECIDUAL(Ubíquo)
Skin Sun Exposed Lower leg
19.1 TPM
Testículo
17.1 TPM
Skin Not Sun Exposed Suprapubic
16.1 TPM
Nervo tibial
15.3 TPM
Útero
14.5 TPM
OUTRAS DOENÇAS (11)
Joubert syndrome 32basal cell nevus syndrome 2familial multiple meningiomamedulloblastoma with extensive nodularity
HGNC:16466UniProt:Q9UMX1
BAP1Ubiquitin carboxyl-terminal hydrolase BAP1Disease-causing somatic mutation(s) inAltamente restrito
VIAS BIOLÓGICAS (2)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksUCH proteinases
OUTRAS DOENÇAS (8)
Kury-Isidor syndromeBAP1-related tumor predisposition syndromecomplex neurodevelopmental disordermeningioma
HGNC:950UniProt:Q92560
SMARCE1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1Disease-causing germline mutation(s) (loss of function) inAltamente restrito
VIAS BIOLÓGICAS (8)
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownRMTs methylate histone argininesFormation of neuronal progenitor and neuronal BAF (npBAF and nBAF)Formation of the embryonic stem cell BAF (esBAF) complexFormation of the polybromo-BAF (pBAF) complex
MECANISMO DE DOENÇA

Meningioma

A common neoplasm of the central nervous system derived from arachnoidal cells. The majority of meningiomas are well differentiated vascular tumors which grow slowly and have a low potential to be invasive, although malignant subtypes occur. Most cases are sporadic. Familial occurrence of meningioma is rare.

EXPRESSÃO TECIDUAL(Ubíquo)
Útero
58.4 TPM
Cervix Endocervix
51.0 TPM
Fibroblastos
47.8 TPM
Artéria tibial
45.6 TPM
Cervix Ectocervix
45.5 TPM
OUTRAS DOENÇAS (5)
Coffin-Siris syndrome 5familial multiple meningiomameningiomaCoffin-Siris syndrome
HGNC:11109UniProt:Q969G3
SMOProtein smoothenedDisease-causing somatic mutation(s) inTolerante
VIAS BIOLÓGICAS (1)
Hedgehog 'off' state
EXPRESSÃO TECIDUAL(Ubíquo)
Cervix Endocervix
62.8 TPM
Ovário
60.7 TPM
Cervix Ectocervix
56.8 TPM
Útero
50.1 TPM
Pituitária
38.7 TPM
OUTRAS DOENÇAS (5)
congenital hypothalamic hamartoma syndromebasal cell carcinoma, susceptibility to, 1Curry-Jones syndromemeningioma
HGNC:11119UniProt:Q99835
TRAF7E3 ubiquitin-protein ligase TRAF7Disease-causing somatic mutation(s) inTolerante
VIAS BIOLÓGICAS (1)
Antigen processing: Ubiquitination & Proteasome degradation
MECANISMO DE DOENÇA

Cardiac, facial, and digital anomalies with developmental delay

An autosomal dominant disorder characterized by delayed motor and speech development, developmental regression, congenital heart defects, limb and digital anomalies, and dysmorphic features. Cardiac features include pulmonary stenosis, patent ductus arteriosus, aortic coarctation, valvular defects, hypoplastic left heart, double outlet right ventricle, and conduction abnormalities. Dysmorphic facial features include multiple hair whorls or hairline abnormalities, ptosis, epicanthal folds, and low-set or dysplastic ears.

EXPRESSÃO TECIDUAL(Ubíquo)
Fibroblastos
87.5 TPM
Esôfago - Mucosa
70.4 TPM
Skin Sun Exposed Lower leg
68.9 TPM
Linfócitos
65.8 TPM
Fallopian Tube
64.5 TPM
INTERAÇÕES PROTEICAS (5)
OUTRAS DOENÇAS (3)
cardiac, facial, and digital anomalies with developmental delaymeningiomaTRAF7-associated heart defect-digital anomalies-facial dysmorphism-motor and speech delay syndrome
HGNC:20456UniProt:Q6Q0C0

Medicamentos e terapias

MIFEPRISTONEPhase 3

Mecanismo: Progesterone receptor antagonist

TRANEXAMIC ACIDPhase 3

Mecanismo: Plasminogen inhibitor

OCTREOTIDEPhase 2

Mecanismo: Somatostatin receptor agonist

IPILIMUMABPhase 2

Mecanismo: Cytotoxic T-lymphocyte protein 4 inhibitor

EVEROLIMUSPhase 2

Mecanismo: FK506-binding protein 1A inhibitor

NIVOLUMABPhase 2

Mecanismo: Programmed cell death protein 1 inhibitor

PASIREOTIDEPhase 2

Mecanismo: Somatostatin receptor 1 agonist

LUTETIUM OXODOTREOTIDE LU-177Phase 2

Mecanismo: Somatostatin receptor binding agent

LUTETIUM OXODOTREOTIDEPhase 2

Mecanismo: Somatostatin receptor binding agent

Ver mais no OpenTargets

Variantes genéticas (ClinVar)

2.225 variantes patogênicas registradas no ClinVar.

🧬 AKT1: GRCh37/hg19 14q32.2-32.33(chr14:97521552-107285437)x3 ()
🧬 AKT1: GRCh37/hg19 14q32.2-32.33(chr14:101180490-106329074)x1 ()
🧬 AKT1: NM_001382430.1(AKT1):c.16A>C (p.Ile6Leu) ()
🧬 AKT1: NM_001382430.1(AKT1):c.286_287del (p.Arg96fs) ()
🧬 AKT1: NM_001382430.1(AKT1):c.237G>C (p.Gln79His) ()
Ver todas no ClinVar

Classificação de variantes (ClinVar)

Distribuição de 1.228 variantes classificadas pelo ClinVar.

246
614
368
Patogênica (20.0%)
VUS (50.0%)
Benigna (30.0%)
VARIANTES MAIS SIGNIFICATIVAS
SMARCE1: NM_003079.5(SMARCE1):c.121del (p.Leu41fs) [Pathogenic]
SMARCE1: NM_003079.5(SMARCE1):c.9_12del [Likely pathogenic]
SMARCE1: NM_003079.5(SMARCE1):c.773_774del (p.Lys258fs) [Likely pathogenic]
SMARCE1: NM_003079.5(SMARCE1):c.167dup (p.Ile57fs) [Likely pathogenic]
SMARCE1: NM_003079.5(SMARCE1):c.897G>T (p.Arg299Ser) [Uncertain significance]

Vias biológicas (Reactome)

93 vias biológicas associadas aos genes desta condição.

Activation of BAD and translocation to mitochondria PIP3 activates AKT signaling Downregulation of ERBB2:ERBB3 signaling Translocation of SLC2A4 (GLUT4) to the plasma membrane Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation MTOR signalling AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the nucleus Negative regulation of the PI3K/AKT network eNOS activation AKT-mediated inactivation of FOXO1A Integrin signaling Deactivation of the beta-catenin transactivating complex CD28 dependent PI3K/Akt signaling Co-inhibition by CTLA4 G beta:gamma signalling through PI3Kgamma Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Interleukin-4 and Interleukin-13 signaling Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 RAB GEFs exchange GTP for GDP on RABs Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Downstream TCR signaling PTEN Loss of Function in Cancer Ub-specific processing proteases Ovarian tumor domain proteases Regulation of PTEN mRNA translation Regulation of PTEN localization Regulation of PTEN stability and activity Transcriptional Regulation by MECP2 RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Telomere Extension By Telomerase Formation of the beta-catenin:TCF transactivating complex Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence Platelet degranulation Downstream signal transduction Signaling by PDGF Constitutive Signaling by Aberrant PI3K in Cancer Non-integrin membrane-ECM interactions RAF/MAP kinase cascade PI3K Cascade IRS-mediated signalling GPVI-mediated activation cascade Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PI3K events in ERBB4 signaling Signaling by SCF-KIT GAB1 signalosome Signaling by cytosolic FGFR1 fusion mutants PI3K events in ERBB2 signaling PI3K/AKT activation Signaling by ALK Role of phospholipids in phagocytosis Tie2 Signaling DAP12 signaling Role of LAT2/NTAL/LAB on calcium mobilization Nephrin family interactions G alpha (q) signalling events VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling Constitutive Signaling by EGFRvIII PI-3K cascade:FGFR1 PI-3K cascade:FGFR2 PI-3K cascade:FGFR3 PI-3K cascade:FGFR4 Regulation of actin dynamics for phagocytic cup formation RHO GTPases activate PAKs Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'off' state Hedgehog 'on' state UCH proteinases Epigenetic regulation of gene expression by MLL3 and MLL4 complexes PAOs oxidise polyamines to amines Interconversion of polyamines Antigen processing: Ubiquitination & Proteasome degradation

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
✓Aprovado2
3Fase 35
2Fase 239
1Fase 17
·Pré-clínico56
Medicamentos catalogadosEnsaios clínicos· 9 medicamentos · 100 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Meningioma

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

Onde estão os ensaios

Com ensaio aberto em 19 países. O ponto verde marca onde há vaga agora.

🟢 Recrutando agora

63 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

NCT06804655 · Pharmacoscopy for Patients With Refractory Primary Brain Tum…Recrutando
PHASE2🇨🇭 Suíça
NCT07652762 · IN10018 in Combination With Dalpiciclib for Progressive Meni…Recrutando
PHASE1🇨🇳 China
NCT07533942 · A Study of JZP3507 (ONC206) in Recurrent Grade 2 or 3 Mening…Recrutando
PHASE2🇺🇸 Estados Unidos
NCT07398170 · Search for Circulating Tumour Cells in the Blood and/or Cere…Recrutando
NA🇫🇷 França
NCT07493447 · Pilot Study Evaluating Panitumumab-IRDye800 as an Optical Im…Recrutando
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251 ensaios clínicos encontrados, 97 ativos.

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Publicações mais relevantes

Timeline de publicações
10.505 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 10.505

#1

Diagnostic yield from minimally invasive pediatric brain tumor biopsies in the molecular era.

Journal of neurosurgery. Pediatrics2026 Mar 20

Este estudo avaliou a eficácia de biópsias minimamente invasivas (endoscópicas, guiadas por robô e por imagem óptica) em tumores cerebrais pediátricos, revelando altas taxas de diagnóstico histológico (88,3%) e molecular (82,0%). Para pacientes e médicos, as técnicas guiadas por robô e por imagem óptica mostraram ser as mais eficazes, com rendimentos diagnósticos de 97,5% e 91,4%, respectivamente, superando as biópsias endoscópicas (com 19,2% de resultados não diagnósticos). É importante notar que o meningioma foi diagnosticado em apenas 0,5% dos casos estudados, indicando que este artigo não oferece informações substanciais sobre o rendimento diagnóstico específico para meningiomas em crianças, devido à sua raridade nesta coorte.

🇧🇷 traduzido
#2

Surgical management of petrous apex lesions: a descriptive analysis of outcomes by anatomical location for the Kawase, retrosigmoid, and pterional approaches.

Frontiers in neurology2026

Este estudo retrospectivo analisou três abordagens cirúrgicas (Kawase, retrosigmoide e pterional) para lesões no ápice petroso, incluindo meningiomas, mostrando que a escolha da técnica é crucial e determinada pela localização anatômica da lesão. Cada abordagem apresentou um perfil distinto de resultados e complicações: enquanto a abordagem de Kawase (para lesões anteromediais) alcançou alta taxa de remoção, teve maior risco de infecção, e a pterional (para superoanteriores) foi associada a maiores taxas de disfunção de nervos cranianos e fala. Para pacientes e médicos, os achados enfatizam que a decisão cirúrgica deve priorizar a localização precisa da lesão, reconhecendo os riscos e benefícios inerentes a cada abordagem específica.

🇧🇷 traduzido
#3

The "O-Ring" technique is effective in reducing cerebrospinal fluid leak in posterior fossa surgery.

Journal of neurosurgical sciences2026 Mar 13

Em cirurgias de fossa posterior, frequentemente realizadas para remover meningiomas, o vazamento de líquido cefalorraquidiano (LCR) é uma complicação comum. Este estudo demonstrou que a técnica "O-ring", que utiliza uma cranioplastia de PMMA para reparar o defeito ósseo, foi altamente eficaz em reduzir essa complicação, com praticamente nenhum vazamento externo ou pseudomeningocele observado. Essa abordagem inovadora oferece resultados promissores para pacientes e neurocirurgiões, aumentando a segurança e melhorando os desfechos pós-operatórios.

🇧🇷 traduzido
#4

Transdural Cisternotomy in the Extended Middle Fossa Approach.

Neurology India2026 Mar 01

Este artigo descreve a "cisternotomia transdural", uma nova técnica cirúrgica para abordagens na base do crânio (como as EMFAs) frequentemente usadas para tumores como meningiomas. As cirurgias convencionais podem causar inchaço cerebral, dificultando o procedimento e aumentando riscos para o paciente. A técnica inovadora drena precocemente o líquido cefalorraquidiano, promovendo um relaxamento cerebral significativo. Isso facilita a remoção completa do tumor e reduz o risco de complicações pós-operatórias, oferecendo um método eficaz e reprodutível que melhora os resultados para os pacientes e a segurança para os médicos.

🇧🇷 traduzido
#5

Trigeminal Neurosarcoidosis as a Neurosurgical Dilemma: A Literature Review and Illustrative Case.

Neurology India2026 Mar 01

Este artigo destaca que a neurosarcoidose trigeminal isolada (TNS) é uma condição rara que, radiologicamente, mimetiza tumores comuns como schwannoma ou meningioma, criando um desafio diagnóstico significativo para médicos. Para pacientes e médicos, é crucial saber que a biópsia de tecido é indispensável para o diagnóstico definitivo, e a cirurgia, quando necessária, deve ser limitada à coleta da biópsia ou ressecção parcial para minimizar a morbidade, sendo o tratamento médico a abordagem principal após a confirmação.

🇧🇷 traduzido

Publicações recentes

Ver todas no PubMed

📚 EuropePMC11.487 artigos no totalmostrando 196

2026

Diagnostic yield from minimally invasive pediatric brain tumor biopsies in the molecular era.

Journal of neurosurgery. Pediatrics
2026

Molecularly distinct collision tumor consisting of meningothelial meningioma and glioblastoma, IDH-wildtype: illustrative case.

Journal of neurosurgery. Case lessons
2026

Risk factors for nonresolving neurological deficits after spinal meningioma surgery: an integrated clinical and volumetric analysis of 202 patients.

Journal of neurosurgery. Spine
2026

Extracranial metastasis in histologically benign meningiomas: unpredictable behavior in WHO grade 1 tumors. Illustrative cases.

Journal of neurosurgery. Case lessons
2026

Frontotemporal-orbitozygomatic approach for pediatric cranio-orbital tumors: a single-center experience.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
2026

The Causal Role of Circulating Inflammatory Cytokines in Brain Tumors: Insights from Genetic Epidemiology.

Immunological investigations
2026

Solitary intracranial dural-based Ewing's sarcoma in a pregnant female: A case report.

Radiology case reports
2026

Efficacy of a Novel Dimeric Macrocyclic Gadolinium Chelate With High Relaxivity in Preclinical Models of Neurological and Oncological Pathologies.

Investigative radiology
2026

French translation and preliminary psychometric evaluation of the Meningioma Quality of Life questionnaire (MQOL-FR).

Neuro-Chirurgie
2026

Homologous recombination repair germline variants and subsequent neoplasm risk among childhood cancer survivors.

JNCI cancer spectrum
2026

A systematic review and meta-analysis of outcomes following active surveillance, surgery and radiotherapy of meningiomas in NF2-related schwannomatosis.

Neuro-oncology advances
2026

Peritumoral Cystic Meningioma With Diagnostic Challenges: Two Case Reports and a Literature Review.

Cureus
2026

Advances in molecular and genetic profiling of meningiomas for improved diagnosis, prognosis, and targeted therapy.

Frontiers in oncology
2026

Profiling of rare immune cell populations and integrative analysis identify immune ecotypes in newly diagnosed meningiomas.

Acta neuropathologica communications
2026

Microsurgical Resection of an Atrium Meningioma via the Posterior Interhemispheric Transparieto-Occipital Fissure Approach: 2-Dimensional Operative Video.

Operative neurosurgery (Hagerstown, Md.)
2026

Network connectome analysis of multi omics data identifies molecular markers of recurrence and grade progression in meningioma.

Frontiers in oncology
2026

AI-driven label-free Raman spectromics for intraoperative spinal tumor assessment.

NPJ digital medicine
2026

Regulatory mechanisms and functional analysis of cellular senescence-associated genes GAPDH, CCND1, and HBEGF in the immune microenvironment of meningioma.

BMC cancer
2026

Primary pulmonary meningioma: a case report and literature review.

International journal of surgery case reports
2026

Epigenetic buffering of proteotoxic stress by EHMT2 enables meningioma growth.

Neuro-oncology advances
2026

Neuroendocrine Tumor of the Cauda Equina: A Report of a Rare Case With Histopathological and Immunohistochemical Correlation.

Cureus
2026

Surgical management of petrous apex lesions: a descriptive analysis of outcomes by anatomical location for the Kawase, retrosigmoid, and pterional approaches.

Frontiers in neurology
2026

Role of 68Ga-DOTA-TOC PET/CT in the Evaluation of Meningiomas with Osseous Involvement.

JPMA. The Journal of the Pakistan Medical Association
2026

Differentiation of Intracranial Dural Metastases and Meningiomas Using DSC Perfusion MRI and Machine Learning.

Diagnostics (Basel, Switzerland)
2026

IgG4-Related Disease Manifested as Hypertrophic Pachymeningitis: A Case Report and Literature Review.

Diagnostics (Basel, Switzerland)
2026

Chopsticks mononostril approach with sphenoid sinus cranialization and septal mucosa suturing: a new minimally invasive concept and closure technique for endoscopic endonasal approaches.

Journal of neurosurgery
2026

The "O-Ring" technique is effective in reducing cerebrospinal fluid leak in posterior fossa surgery.

Journal of neurosurgical sciences
2026

In Vivo Hyperspectral Imaging of Vasogenic Edema and Cortical Oxygenation in Meningiomas: A Subgroup Interim Analysis of a Prospective Study.

Neurosurgery
2026

A multi-model fusion approach incorporating conventional radiological and machine learning features across age spectrum for periorbital fat status prediction.

Frontiers in medicine
2026

Recurrent Primary Extracranial Meningioma: A Case Report and Literature Review of a Rare Scalp Tumor.

Cureus
2026

Fluorescence-guided surgery combined with intraoperative photodynamic therapy for recurrent atypical and anaplastic intracranial meningiomas: a prospective feasibility study.

Frontiers in oncology
2026

From sunburst to mother-in-law sign in intracranial meningioma: a matter of time.

Acta neurologica Belgica
2026

Associations of surgical menopause and hormone replacement therapy with meningioma development.

Journal of neuro-oncology
2026

Spheno-Orbital Meningioma With an Orbital Cystic Component.

Ophthalmic plastic and reconstructive surgery
2026

Transdural Cisternotomy in the Extended Middle Fossa Approach.

Neurology India
2026

Trigeminal Neurosarcoidosis as a Neurosurgical Dilemma: A Literature Review and Illustrative Case.

Neurology India
2026

A case of trigeminal nerve neurosarcoidosis initially presenting with isolated neurological findings mimicking trigeminal schwannoma: a case report and review of the literature.

Journal of medical case reports
2026

Laser interstitial thermal therapy for intracranial dural-based lesions: A single center case series of 20 patients.

Clinical neurology and neurosurgery
2026

Olfactory Groove Meningioma Presenting With Visual Decline and Gait Disturbance: A Case Report.

Cureus
2026

Efficient attention-based Ghost-ResNet for brain tumor classification in magnetic resonance imaging (MRI).

Frontiers in neuroscience
2026

Stereotactic radiosurgery (SRS) for primary intradural spinal tumors: A systematic review and meta-analysis.

Neurosurgical review
2026

A Rare Case of Pulmonary Metastasis From Intracranial Grade 2 Meningioma.

Cureus
2026

Hybrid Aquila optimizer-Harris Hawks optimization for CNN hyperparameter tuning in brain tumor classification.

Scientific reports
2026

Long-term relief of refractory trigeminal neuropathy using high-frequency spinal cord stimulation at the cervicomedullary junction: a 6-year follow-up case report.

Frontiers in neuroscience
2026

Molecular mechanisms and therapeutic targeting implications of ER/mTOR signaling axis-driven tumor progression in aggressive meningiomas.

Translational oncology
2026

Investigating the clinical significance of systemic inflammatory indices for post-treatment peritumoral edema after gamma knife radiosurgery for meningioma.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
2026

Translation and Validation of the Neurologic Assessment in Neuro-Oncology Scale into Indonesian (NANO-Ina).

Asian Pacific journal of cancer prevention : APJCP
2026

Prognostic stratification of chordoid meningiomas: the role of chromosome 1p/22q Loss.

Acta neuropathologica communications
2026

3D digital exoscope is safe tool in the surgery of olfactory groove meningiomas.

Acta neurochirurgica
2026

Diagnostic value of cellular inflammatory markers in CNS tumor patients undergoing glucocorticoid therapy.

Frontiers in oncology
2025

[The role of histopathology in the diagnosis and management of intracranial meningiomas. Hospital experience in Kinshasa (Democratic Republic of Congo)].

Medecine tropicale et sante internationale
2026

Variances in 3D radiomic shape features between meningioma, acoustic neuroma, and pituitary adenoma and the impact on dosimetric plan quality in Gamma Knife stereotactic radiosurgery.

Biomedical physics &amp; engineering express
2025

Posterolateral Approach for Recurrent multi-level Ventral Intradural Extramedullary Cervical Spinal Meningioma.

Turkish neurosurgery
2026

Blindness after middle meningeal artery embolization for skull metastasis of follicular thyroid carcinoma with ophthalmic artery variant.

Surgical neurology international
2026

Elderly patient with a calcified upper cervical meningioma acutely worsened by head trauma.

Surgical neurology international
2026

Multilayer dural repair using absorbable artificial dura in the posterior fossa: A case report on the "sandwich technique".

Surgical neurology international
2026

Cavernous sinus meningiomas: A retrospective study of natural history, growth dynamics, and treatment response over two decades.

Surgical neurology international
2026

Spontaneous Regression of Meningiomas: Literature Review and Case Report.

Asian journal of neurosurgery
2026

A single MRI scan contains sufficient imaging information for accurate prediction of meningioma growth risk.

NeuroImage. Clinical
2026

Drug screening on tumor organoids exposes therapeutic vulnerabilities of meningiomas to HDAC1/2i panobinostat.

Science translational medicine
2026

Brief results of heterotopic xenotransplantation of meningioma into the peritoneum of Wistar rats: an experimental study.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
2026

The "Trimeric" Anterolateral Thigh Free Flap: A Novel Technique for the Reconstruction of Complex Cranio-Orbital and Middle Skull Base Defects.

Operative neurosurgery (Hagerstown, Md.)
2026

Diagnostic Challenge of a Tumor-mimicking Spinal Pseudogout Lesion: Case Report and Literature Review.

Cancer diagnosis &amp; prognosis
2026

[Pediatric parasagittal meningioma, case report].

Revista medica del Instituto Mexicano del Seguro Social
2026

Spectrum of non-ischemic oculomotor nerve palsies at a tertiary care centre - case series and literature review.

Strabismus
2026

Diffuse pulmonary meningotheliomatosis in resected lung adenocarcinoma: a rare incidental finding.

BMJ case reports
2026

Lung Metastases from Meningioma Diagnosed on Whole Body 68Ga-DOTATOC PET/CT and Successfully Targeted With 177Lu-DOTATATE.

Clinical nuclear medicine
2026

Human Meningiomas Reveal No Evidence of Neuroendocrine Differentiation.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
2026

Single-Stage Resection and Reconstruction of Intraosseous Meningioma: The First Reported Case at Our Hospital.

Cureus
2026

Current landscape of single-cell genomics in meningioma.

Neuro-oncology advances
2026

Voxel-based spatial distribution of intracranial meningioma subtypes and their relationship to radiogenomic maps.

Brain communications
2026

Contrast-Enhanced Vessel Wall Imaging in Determining Angioplasty Suitability for Radiation-Induced Stenosis: A Case Report.

Journal of UOEH
2026

Unusual immunohistochemical profiles in hemangioblastomas and their relevance in differential diagnosis: A comprehensive study of 112 cases.

Journal of neuropathology and experimental neurology
2026

Induction of Meningioma Stem Signature via Hydrogel Reprogramming and Application of Meningioma Stem Cell Marker CXCR4 to Pathological Diagnosis and Treatment.

Biotechnology and bioengineering
2026

Primary Dural Diffuse Large B-Cell Lymphoma: A Report of a Rare Case and Review of the Literature.

Cureus
2026

Distant Metastases of an Atypical Meningioma 14 Years Later After Primary Tumor Resection: A Case Report and Review of the Literature.

Case reports in pathology
2026

Two-Week Interval Hypofractionated Stereotactic Radiosurgery for Benign Intracranial Tumors: Volumetric Kinetics and Radiobiological Rationale.

Cancers
2026

A Robust ConvNeXt-Based Framework for Efficient, Generalizable, and Explainable Brain Tumor Classification on MRI.

Bioengineering (Basel, Switzerland)
2026

An Evaluation Study of PET Image Quality Factors in Brain Tumor Diagnosis.

Tomography (Ann Arbor, Mich.)
2026

Minimally Invasive Surgical Strategies in Intraventricular Tumors: Preliminary Experience with Tubular Retractors for a Personalized Approach in Intraventricular Meningiomas.

Journal of personalized medicine
2026

Resection of the Clinoidal meningioma Encasing the Carotid Artery: A Complex and Delicate Surgical Procedure.

World neurosurgery
2026

Late-onset vascular and tumor complications after childhood brain radiotherapy: A rare case of dual sequelae.

Radiology case reports
2026

Progestogen use and the risk of intracranial meningioma: a systematic review and meta-analysis.

EClinicalMedicine
2026

Single-Fraction Stereotactic Radiosurgery for Benign Perioptic Meningiomas: A Strategy for Long-Term Tumor Control and Radiation-Induced Optic Neuropathy Avoidance With a 10-Year Follow-up.

Journal of Korean medical science
2026

[68Ga]-DOTATATE PET SUV Reduction After Bevacizumab in High-Grade Meningioma: A Potential Treatment Response Biomarker.

AJNR. American journal of neuroradiology
2026

Mask - Region-based Convolutional Neural Networks (R-CNN) with Radiomics Integration and Gray Level Co-occurrence Matrix (GLCM) for brain tumor detection and segmentation.

PloS one
2026

A Two-way Mendelian randomisation study of inflammatory factors and the risk of meningioma.

Translational neuroscience
2026

Exoscopic Resection of an Olfactory Groove Meningioma Through an Anterior Interhemispheric Approach.

World neurosurgery
2026

Glucagon-like peptide-1 receptor agonists and the risk of obesity-related cancers: a systematic review and meta-analysis.

Diabetes research and clinical practice
2026

Diagnostic Performance of Microstructural Parameters Derived From Time-dependent Diffusion MRI for Grading Meningiomas: A Prospective Study.

Academic radiology
2026

Gadolinium-Enhanced Portable Ultra-Low Field MRI for Evaluating Various Intracranial Pathologies.

AJNR. American journal of neuroradiology
2026

Hypofractionated palliative-intent radiation therapy for a postsurgical recurrent grade II cervical spinal meningioma in a dog.

The Canadian veterinary journal = La revue veterinaire canadienne
2025

An unusual facial location for a meningioma. Case report.

Journal of clinical and experimental dentistry
2026

Clinicopathological significance of loss of Y chromosome in male meningiomas.

The Journal of pathology
2026

Hybrid deep neural network with PCA based features optimization for enhancing brain tumor classification.

Scientific reports
2026

Meningioma-like inflammatory myofibroblastic tumor of the lung with TPM3::ALK fusion.

Virchows Archiv : an international journal of pathology
2026

Peritumoral edema in meningiomas: a review of influencing factors, mechanisms, and management.

Frontiers in oncology
2026

[Future Perspectives of Middle Meningeal Artery Embolization for Meningioma and Chronic Subdural Hematoma].

No shinkei geka. Neurological surgery
2026

Incidence of meningioma in women with a history of combined oral contraceptive pill use and polycystic ovary syndrome.

Women's health (London, England)
2026

Meningioma theranostics: a retrospective analysis of somatostatin receptor PET/CT imaging and peptide receptor radionuclide therapy.

European journal of nuclear medicine and molecular imaging
2026

Utility of digital PCR for detecting TERT promoter mutations and CDKN2A homozygous deletion in meningioma.

Brain tumor pathology
2026

Brain tumor classification using optimized ResNet50 with dynamic precision optimization for enhanced speed and diagnostic accuracy.

Scientific reports
2026

Optic nerve sheath meningiomas harbor distinct genetic variants.

American journal of clinical pathology
2026

Diabetes prolongs hospitalization and increases infection, cerebral edema, and neurological complications in meningioma patients: A retrospective study.

World journal of diabetes
2026

Clinical characteristics of petroclival meningioma and the impact of resection degree on its prognosis.

Frontiers in neurology
2026

Case Report: Meningioma with unusual extracranial extension to the temple and orbit.

Frontiers in oncology
2026

A schwannoma of the olfactory nerve: a case report of a diagnostic challenge and review of the literature.

Journal of surgical case reports
2026

Somatostatin receptor PET in meningioma: diagnosis, therapy, and surveillance.

Nuclear medicine communications
2026

Timing of adjuvant radiotherapy impacts overall survival for atypical intracranial meningiomas: a National Cancer Database (NCDB) analysis.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
2026

MRI and Meningioma Research: Hotspots and Trends via Bibliometric Analysis.

Current medical imaging
2026

Deciding when and when not to reconstruct the orbit: How I do it.

Acta neurochirurgica
2026

Definitive embolization of meningiomas: a 20-year updated systematic review.

Journal of neurointerventional surgery
2026

Spinal extradural meningioma mimicking lumbar disc herniation in a cat: a case report.

BMC veterinary research
2026

Boron Neutron Capture Therapy: A Technology-Driven Renaissance.

Cancers
2026

Optimal α/β Ratio for Biologically Effective Dose-Based Prediction of Radiation-Induced Peritumoral Brain Edema in Meningioma.

Cancers
2026

STING activation induces cytotoxic and immune responses in meningiomas via inflammatory cell death pathways.

Nature communications
2026

T2-Weighted MRI Signal Intensity Ratio Predicts Intraoperative Intracranial Meningioma Consistency: A Retrospective Cohort Study.

Neurosurgery
2026

Integrated Clinical Genetic Analysis Reveals Transcriptional Neurotransmitter Receptor Dysregulation in Meningiomas Causing Seizure.

Neurosurgery
2025

Mendelian randomization identifies the characteristic plasma metabolite profile of meningioma.

Archives of medical science : AMS
2026

Crista Galli Pneumatization Complicating Olfactory Groove Meningioma Resection: A Case Report.

Cureus
2026

A 6-year-old boy with left temporal lobe mass.

Brain pathology (Zurich, Switzerland)
2026

Perfusion changes associated with intratumoral embolization and feeder occlusion for meningiomas: an arterial spin labeling study.

Acta neurochirurgica
2026

The prognostic impact of CDKN2A/B hemizygous deletions in meningioma.

Neuro-oncology
2026

High frequency and unique subtypes of meningioma in patients with BAP1 tumor predisposition syndrome.

Journal of neuro-oncology
2026

Enhancing cancer prognostics with group penalty models: a comparative study on radiomics feature selection in lung adenocarcinomas and meningiomas.

Quantitative imaging in medicine and surgery
2026

[Tentorial meningiomas extending along transverse and sigmoid sinuses to jugular vein bulb].

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko
2026

[Posterior petrous meningiomas: clinical manifestations, anatomical relationships and postoperative outcomes].

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko
2026

[Postoperative complications following resection of extramedullary tumors of the craniovertebral junction region].

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko
2026

Outcomes of Gamma Knife radiosurgery for meningiomas overlying the motor cortex.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
2026

Causal Pathways Linking Gut Microbiota, Serum Metabolites, and Meningioma Risk: A Mendelian Randomization Analysis.

Brain and behavior
2026

Unlocking the full potential of MRI with artificial intelligence for pre-operative meningioma evaluation.

European radiology
2026

Stromal immune cell signatures predict risk of progression in meningioma.

Nature genetics
2026

A microenvironment-determined risk continuum refines subtyping in meningioma and reveals determinants of machine learning-based tumor classification.

Nature genetics
2026

Facial Nerve Outcomes Following Microsurgical Resection of Large Cerebellopontine Angle Tumors: Experience From a Tertiary Care Center in Pakistan.

Brain tumor research and treatment
2026

Fractionated radiotherapy adjuvant to surgery of WHO-2 meningioma with and without gross total resection: a multicenter, retrospective cohort study of 1,452 patients.

Journal of neuro-oncology
2026

Standalone Meningioma Embolization: A Systematic Review.

Neurosurgery
2026

Voxel-Based Mapping of Seizure Risk in Meningioma Identifies the Frontoparietal Interface and Tumor Microenvironment as Key Predictors.

Neurosurgery
2026

Ambient Air Pollution and Risk of Brain Tumors: A Systematic Review and Meta-Analysis.

Asian Pacific journal of cancer prevention : APJCP
2026

Cryptococcal dumbbell inflammatory pseudotumor mimicking skull histiocytic sarcoma in immunocompetent patient.

Surgical neurology international
2026

Radiation-induced meningiomas: A systematic review and meta-analysis of 927 meningiomas.

Surgical neurology international
2026

Microsurgical resection of a primary mixed intramedullary-extramedullary thoracic meningeal melanoma.

Surgical neurology international
2026

BTdiagAI: A Web-Deployed Hybrid Framework for Brain Tumor Classification Using Optimized MRI Preprocessing and Deep Learning Fusion.

Healthcare technology letters
2026

Re: Intracranial primary collision tumours: A comprehensive systematic review on preoperative radiological accuracy and neuro-oncological insights. Brain Spine 2026: 105943.

Brain &amp; spine
2025

Radioligand therapy for primary brain tumors: a PRISMA-based systematic review of meningiomas and gliomas.

Frontiers in medicine
2026

Safety profile of progesterone: Insights from an FDA Adverse Event Reporting System (FAERS)-based pharmacovigilance study.

The Journal of international medical research
2026

Association Between miRNAs and the Diagnosis, Prognosis, and Recurrence of Patients with Meningioma: A Systematic Review.

Cellular and molecular neurobiology
2026

Predictive factors in spinal meningiomas - a comparative analysis with intracranial meningiomas of a high-volume skull and base center.

Neurosurgical review
2026

The effect of modified head-of-bed elevation on postoperative headache and CSF leakage after meningioma resection.

Medicine
2026

Intrasellar meningioma versus pituitary apoplexy in the setting of postpartum hemorrhage: a case report.

BMC pregnancy and childbirth
2026

BRISC: Annotated Dataset for Brain Tumor Segmentation and Classification.

Scientific data
2026

Mechanical instability as a signature of viscoelastic decoupling at the tumor-brain interface.

Biomaterials advances
2026

KMT2C Loss Promotes NF2-Wildtype Meningioma Progression and Ferroptosis Sensitivity via Epigenetic Repression of Hippo Signaling.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
2026

Extracranial meningioma of the masticator space: a rare case report.

Neuroradiology
2026

Reliable and Accurate Differentiation of Optic Perineuritis and Optic Nerve Sheath Meningioma from the Radiologists' Perspective.

Neuro-ophthalmology (Aeolus Press)
2026

Brain MRI Radiomic First-Order Features for Presurgical Prediction of Meningioma Grading.

Journal of neuroimaging : official journal of the American Society of Neuroimaging
2026

FOXC1 expression and radiological predictors of peritumoral brain edema in meningiomas.

Journal of neuro-oncology
2026

Meningioma microenvironment harbors a rich immune landscape that evolves with biological state.

Neuro-oncology
2026

Molecular classification of radiation-induced meningiomas.

International journal of radiation biology
2025

Association of thyroid disease and intracranial meningiomas: a retrospective analysis with external validation.

Frontiers in oncology
2025

The mini-pretemporal approach for skull base neoplasms: A technical note.

Surgical neurology international
2025

Giant skull base meningiomas: Definitions, case reports, and surgical approaches.

Surgical neurology international
2026

Surgical Treatment of Meningioma with Situs Inversus Totalis Assisted by 3D Technology: A Case Report.

Current medical imaging
2026

Optic nerve sheath meningioma exhibits neural niche-associated transcriptomic features and rare copy number variation-linked evolution.

Brain pathology (Zurich, Switzerland)
2026

Gamma knife radiosurgery for meningiomas: a bibliometric analysis and single-center clinical trend study.

Neurosurgical review
2026

Senogenic-senolytic treatment strategies enhance tumor control and can improve survival in murine cancer models: a systematic review.

BMC cancer
2026

Pretemporal Transcavernous Approach to Cavernous Sinus Meningioma with Suprasellar Extension Synchronous with Sphenoid Wing Meningioma: Operative Technique: 2-Dimensional Operative Video.

World neurosurgery
2026

Cutting-edge approaches in pet imaging for gliomas: current applications for neurooncologists and the path to theranostic breakthroughs.

European journal of nuclear medicine and molecular imaging
2026

EXPRESS: Surgical treatment of feline meningioma: a single institution survival analysis.

Journal of feline medicine and surgery
2026

[Ga68]DOTATATE PET in Schwannomas: Distinct Avidity Pattern Supporting Noninvasive Diagnosis.

AJNR. American journal of neuroradiology
2025

Case Report: Pathological confirmation and aggressive postoperative recurrence of WHO grade III rhabdoid meningioma.

Frontiers in medicine
2026

A case of radiation treatment effect mimicking viable, recurrent meningioma on DOTATATE PET imaging.

Neuro-oncology advances
2026

Exploring the Causal Links Between Toxoplasma gondii Infection and Risk of Brain Tumors: A Bidirectional Mendelian Randomization Analysis.

Brain and behavior
2026

Retrospective Analysis of Epidemiology of Intracranial and Spinal Tumor in North Western Part of India: 5-Year Observational Study of 1315 Cases.

Cureus
2026

Peroxisome Proliferator-Activated Receptor (PPAR) Expression Correlates With Tumor Grade and Prognostic Outcome in Meningiomas.

Applied immunohistochemistry &amp; molecular morphology : AIMM
2026

An efficient 3D latent diffusion model for T1-contrast enhanced MRI generation.

Biomedical physics &amp; engineering express
2025

Case Report: Intracranial hemophilic pseudotumor mimicking an aggressive neoplasm: a rare skull-invasive presentation.

Frontiers in surgery
2026

Radioligand Therapy in Meningiomas: Today's Evidence, Tomorrow's Possibilities.

Cancers
2025

Syringomyelia in the Course of Resection of Foramen Magnum Pathology: A Case Report with an Intriguing Therapeutic Solution and Systematic Review.

Brain sciences
2026

Intra-Arterial Radioligand Therapy in Brain Cancer: Bridging Nuclear Medicine and Interventional Neuroradiology.

Diagnostics (Basel, Switzerland)
2026

Giant Right Sphenoid Wing Meningioma as a Reversible Frontal Network Lesion: A Pseudo-bvFTD Case with Venous-Sparing Skull-Base Resection.

Diagnostics (Basel, Switzerland)
2026

Multi-class classification of brain tumors using optimized CNN and transfer learning techniques.

Scientific reports
2026

The 2024 Brain Tumor Segmentation Challenge Meningioma Radiotherapy (BraTS-MEN-RT) dataset.

Scientific data
2026

Malignant Progression of Subependymal Giant Cell Astrocytoma-Imitating Fibrous Meningioma in a Child Carrying a Germline <italic>CHEK2</italic> Mutation.

Pathobiology : journal of immunopathology, molecular and cellular biology
2026

Prognostic significance of H3.K27me3 loss in CNS WHO grade 2 meningiomas: a multicentre clinicopathological study.

Journal of neuro-oncology
2026

Cytologic and Histological Features Distinguishing Myxoid Meningioma From Chordoid Meningioma: A Case Report.

Diagnostic cytopathology
2026

Intracranial primary collision tumours: A comprehensive systematic review on preoperative radiological accuracy and neuro-oncological insights.

Brain &amp; spine
2025

Explainable AI-driven MRI-based brain tumor classification: a novel deep learning approach.

Frontiers in artificial intelligence
2026

Deficiency of SMARCB1 drives an immunosuppressive microenvironment in meningioma.

Acta neuropathologica communications
2026

Explainable Hybrid Deep Learning Framework Integrating MobileNetV2, EfficientNetV2B0, and KNN for MRI-Based Brain Tumor Classification.

Cellular and molecular neurobiology
2026

A scoping review of artificial intelligence applications in meningioma from image analysis to prognostic prediction.

Discover oncology
2026

Efficacy of azacitidine in meningiomas and explorative analyses of underlying molecular mechanisms.

Neurosurgical review
2025

High intra-tumoral and serum matrix metalloproteinase 9 levels are associated with reduced survival of patients with glioblastoma and brain metastases.

Frontiers in oncology
2026

Endoscopic Endonasal Approach for Primary Optic Nerve Sheath Meningioma: A Systematic Review.

World neurosurgery
2025

Distant metastasis of intracranial solitary fibrous tumor preceding resection: illustrative case.

Journal of neurosurgery. Case lessons
2025

Olfactory groove meningioma presenting solely with visual impairment: illustrative case.

Journal of neurosurgery. Case lessons
2025

Glioblastoma eroding through falx cerebri: a rarity or commonly seen? Illustrative case.

Journal of neurosurgery. Case lessons
Ver todos os 11.487 no EuropePMC

Associações

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Doença com base genética

Um médico geneticista pode ajudar no diagnóstico de Meningioma e no aconselhamento genético da família.

Vai consultar um especialista? Confirme o registro dele no conselho.
Conselhos e sociedades

Doenças relacionadas

Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico

Perguntas frequentes

O que as famílias mais perguntam sobre esta doença — cada resposta com a fonte de onde saiu

Respostas geradas por IA a partir das fontes citadas

A herança mendeliana padrão é classificada como não aplicável para a apresentação comum da doença. O tumor está associado a alterações genéticas em genes reguladores celulares, incluindo NF2, AKT1 e PTEN.

Referências

Fontes citadas no texto, publicações do grafo e bases de dados usadas neste verbete

10 publicações do grafo RarasNet (PubMed) · 6 bases de dados. Títulos, periódicos e PMIDs vêm direto da fonte, sem intermediação de IA.

  1. ORPHA:2495
    Orphanet
  2. GARD:7015
    GARD (NIH)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Citar este verbete

Raras. (s.d.). Meningioma. Em Raras — Enciclopédia de Doenças Raras do Brasil. https://raras.org/doenca/meningioma

Formato APA. Conteúdo sob CC BY 4.0 — reuso livre com atribuição.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Compêndio · Raras BR

Meningioma

ORPHA:2495 · MONDO:0016642
Prevalência
Unknown
Herança
Not applicable
CID-10
D32.9 · Neoplasia benigna das meninges, não especificada
CID-11
Ensaios
97 ativos
Medicamentos
13 registrados
Início
All ages
Prevalência
0.0 (Europe)
MedGen
UMLS
C0025286
Wikipedia
Papers 10a

📋 Origem dos dados

Esta página agrega dados de fontes públicas e oficiais. Dados sobre cobertura no SUS (PCDT, CEAF) são verificados ativamente por agente proativo (ver badge no infobox). Demais dados têm atribuição de fonte + data da última sincronização — clique para abrir o original.

Doença rara (ontologia)
fonte: Orphanet
Identificador unificado
fonte: MONDO
Indexação biomédica
fonte: MeSH (NLM)
Moléculas estudadas na doença
fonte: OpenTargets
Alvos terapêuticos
fonte: OpenTargets
Rara