É um tumor que geralmente cresce lentamente e se prende à dura-máter, uma das membranas que envolvem o cérebro e a medula espinhal. Ele é formado por células anormais que se originam nessas membranas (as meninges). Ocorre principalmente em adultos, sendo mais comum em mulheres, e pode apresentar diversas formas quando analisado ao microscópio. Entre os vários tipos, os mais comuns são os meningiomas meningotelial, fibroso e transicional. A maioria dos meningiomas são tumores de Grau I, segundo a classificação da OMS (Organização Mundial da Saúde), enquanto alguns são de Grau II ou III. A maioria dos tipos tem um comportamento semelhante, mas alguns subtipos têm maior probabilidade de retornar (recidivar) e seguir um curso mais agressivo da doença.
Introdução
O que você precisa saber de cara
É um tumor que geralmente cresce lentamente e se prende à dura-máter, uma das membranas que envolvem o cérebro e a medula espinhal. Ele é formado por células anormais que se originam nessas membranas (as meninges). Ocorre principalmente em adultos, sendo mais comum em mulheres, e pode apresentar diversas formas quando analisado ao microscópio. Entre os vários tipos, os mais comuns são os meningiomas meningotelial, fibroso e transicional. A maioria dos meningiomas são tumores de Grau I, segundo a classificação da OMS (Organização Mundial da Saúde), enquanto alguns são de Grau II ou III. A maioria dos tipos tem um comportamento semelhante, mas alguns subtipos têm maior probabilidade de retornar (recidivar) e seguir um curso mais agressivo da doença.
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Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 40 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 76 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
13 genes identificados com associação a esta condição. Padrão de herança: Not applicable.
AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis (PubMed:11882383, PubMed:15526160, PubMed:15861136, PubMed:21432781, PubMed:21620960, PubMed:31204173). This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates (PubMed:11882383, PubMed:15526160, PubMed:21432781, PubMed:21620960, PubMe
CytoplasmNucleusCell membraneMitochondrion intermembrane space
Breast cancer
A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case.
Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins (PubMed:9187108, PubMed:9256433, PubMed:9616126). Also functions as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4)P2/phosphatidylinositol 3,4-diphosphate and PtdIns3P/phosphatidylinositol 3-phosphate with a preference for PtdIns(3,4,5)P3 (PubMed:16824732, PubMed:26504226, PubM
CytoplasmNucleusNucleus, PML bodyCell projection, dendritic spinePostsynaptic densitySecreted
Cowden syndrome 1
An autosomal dominant hamartomatous polyposis syndrome with age-related penetrance. Cowden syndrome is characterized by hamartomatous lesions affecting derivatives of ectodermal, mesodermal and endodermal layers, macrocephaly, facial trichilemmomas (benign tumors of the hair follicle infundibulum), acral keratoses, papillomatous papules, and elevated risk for development of several types of malignancy, particularly breast carcinoma in women and thyroid carcinoma in both men and women. Colon cancer and renal cell carcinoma have also been reported. Hamartomas can be found in virtually every organ, but most commonly in the skin, gastrointestinal tract, breast and thyroid.
Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull (By similarity). May play a role in tumor suppression (Probable)
Nucleus
CEBALID syndrome
An autosomal dominant developmental disorder characterized by global developmental delay, intellectual disability with severe expressive language delay, craniofacial dysmorphism, and structural brain abnormalities. Most patients have an atypical form of rhombencephalosynapsis, a distinctive brain malformation characterized by partial or complete loss of the cerebellar vermis with fusion of the cerebellar hemispheres. Other frequent features include perisylvian polymicrogyria, abnormal posterior clinoid processes, cerebellar hypoplasia or dysplasia, and persistent trigeminal artery.
Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures
Nucleus
Rhabdoid tumor predisposition syndrome 1
A familial cancer syndrome predisposing to renal or extrarenal malignant rhabdoid tumors and to a variety of tumors of the central nervous system, including choroid plexus carcinoma, medulloblastoma, and central primitive neuroectodermal tumors. Rhabdoid tumors are the most aggressive and lethal malignancies occurring in early childhood.
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-de
Nucleus, nucleolusNucleus, nucleoplasmNucleusChromosome, telomereCytoplasmNucleus, PML body
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin (PubMed:26599395). Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound
Secreted
Basal ganglia calcification, idiopathic, 5
A form of basal ganglia calcification, an autosomal dominant condition characterized by symmetric calcification in the basal ganglia and other brain regions. Affected individuals can either be asymptomatic or show a wide spectrum of neuropsychiatric symptoms, including parkinsonism, dystonia, tremor, ataxia, dementia, psychosis, seizures, and chronic headache. Serum levels of calcium, phosphate, alkaline phosphatase and parathyroid hormone are normal. The neuropathological hallmark of the disease is vascular and pericapillary calcification, mainly of calcium phosphate, in the affected brain areas.
Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides (PubMed:15135396, PubMed:23936502, PubMed:28676499). Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (PubMed:15135396, PubMed:28676499). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1,
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppress
Cell projection, filopodium membraneCell projection, ruffle membraneNucleusCytoplasm, perinuclear regionCytoplasmic granuleCytoplasm, cytoskeleton
Schwannomatosis, vestibular
An autosomal dominant neoplasia syndrome characterized by the development of multiple benign nerve sheath tumors called schwannomas, particularly affecting the vestibular nerve. Affected individuals usually present with bilateral vestibular schwannomas but can have schwannomas on other cranial, spinal, and peripheral/cutaneous nerves. Meningiomas are common, whereas 20 to 35% of affected individuals develop intramedullary spinal cord tumors called ependymomas. The condition is also characterized by several ophthalmic features such as lenticular opacities, retinal hamartoma, epiretinal membranes.
Negative regulator in the hedgehog/smoothened signaling pathway (PubMed:10559945, PubMed:10564661, PubMed:10806483, PubMed:12068298, PubMed:12975309, PubMed:15367681, PubMed:22365972, PubMed:24217340, PubMed:24311597, PubMed:27234298, PubMed:28965847). Down-regulates GLI1-mediated transactivation of target genes (PubMed:15367681, PubMed:24217340, PubMed:24311597). Down-regulates GLI2-mediated transactivation of target genes (PubMed:24217340, PubMed:24311597). Part of a corepressor complex that a
CytoplasmNucleus
Medulloblastoma
Malignant, invasive embryonal tumor of the cerebellum with a preferential manifestation in children.
Plays a role in coupling actin fibers to cell junctions in endothelial cells, via its interaction with AMOTL2 and CDH5 (By similarity). May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity)
Cell junction, tight junctionCell membrane
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). Durin
Nucleus
Meningioma
A common neoplasm of the central nervous system derived from arachnoidal cells. The majority of meningiomas are well differentiated vascular tumors which grow slowly and have a low potential to be invasive, although malignant subtypes occur. Most cases are sporadic. Familial occurrence of meningioma is rare.
Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3
CytoplasmNucleus
E3 ubiquitin and SUMO-protein ligase that plays a role in different biological processes such as innate immunity, inflammation or apoptosis (PubMed:15001576, PubMed:37086853). Potentiates MAP3K3-mediated activation of JUN/AP1 and DDIT3 transcriptional regulators (PubMed:14743216). Negatively regulates MYB transcriptional activity by sequestering it to the cytosol via SUMOylation (By similarity). Plays a role in the phosphorylation of MAPK1 and/or MAPK3, probably via its interaction with MAP3K3.
Cytoplasmic vesicleCytoplasmNucleus
Cardiac, facial, and digital anomalies with developmental delay
An autosomal dominant disorder characterized by delayed motor and speech development, developmental regression, congenital heart defects, limb and digital anomalies, and dysmorphic features. Cardiac features include pulmonary stenosis, patent ductus arteriosus, aortic coarctation, valvular defects, hypoplastic left heart, double outlet right ventricle, and conduction abnormalities. Dysmorphic facial features include multiple hair whorls or hairline abnormalities, ptosis, epicanthal folds, and low-set or dysplastic ears.
Medicamentos e terapias
Mecanismo: Progesterone receptor antagonist
Mecanismo: Plasminogen inhibitor
Mecanismo: Somatostatin receptor agonist
Mecanismo: Cytotoxic T-lymphocyte protein 4 inhibitor
Mecanismo: FK506-binding protein 1A inhibitor
Mecanismo: Programmed cell death protein 1 inhibitor
Mecanismo: Somatostatin receptor 1 agonist
Mecanismo: Somatostatin receptor binding agent
Mecanismo: Somatostatin receptor binding agent
Variantes genéticas (ClinVar)
2,225 variantes patogênicas registradas no ClinVar.
Classificação de variantes (ClinVar)
Distribuição de 1,228 variantes classificadas pelo ClinVar.
Vias biológicas (Reactome)
93 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Meningioma
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Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
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Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
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Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 10.505
Diagnostic yield from minimally invasive pediatric brain tumor biopsies in the molecular era.
Este estudo avaliou a eficácia de biópsias minimamente invasivas (endoscópicas, guiadas por robô e por imagem óptica) em tumores cerebrais pediátricos, revelando altas taxas de diagnóstico histológico (88,3%) e molecular (82,0%). Para pacientes e médicos, as técnicas guiadas por robô e por imagem óptica mostraram ser as mais eficazes, com rendimentos diagnósticos de 97,5% e 91,4%, respectivamente, superando as biópsias endoscópicas (com 19,2% de resultados não diagnósticos). É importante notar que o meningioma foi diagnosticado em apenas 0,5% dos casos estudados, indicando que este artigo não oferece informações substanciais sobre o rendimento diagnóstico específico para meningiomas em crianças, devido à sua raridade nesta coorte.
🇧🇷 traduzidoSurgical management of petrous apex lesions: a descriptive analysis of outcomes by anatomical location for the Kawase, retrosigmoid, and pterional approaches.
Este estudo retrospectivo analisou três abordagens cirúrgicas (Kawase, retrosigmoide e pterional) para lesões no ápice petroso, incluindo meningiomas, mostrando que a escolha da técnica é crucial e determinada pela localização anatômica da lesão. Cada abordagem apresentou um perfil distinto de resultados e complicações: enquanto a abordagem de Kawase (para lesões anteromediais) alcançou alta taxa de remoção, teve maior risco de infecção, e a pterional (para superoanteriores) foi associada a maiores taxas de disfunção de nervos cranianos e fala. Para pacientes e médicos, os achados enfatizam que a decisão cirúrgica deve priorizar a localização precisa da lesão, reconhecendo os riscos e benefícios inerentes a cada abordagem específica.
🇧🇷 traduzidoThe "O-Ring" technique is effective in reducing cerebrospinal fluid leak in posterior fossa surgery.
Em cirurgias de fossa posterior, frequentemente realizadas para remover meningiomas, o vazamento de líquido cefalorraquidiano (LCR) é uma complicação comum. Este estudo demonstrou que a técnica "O-ring", que utiliza uma cranioplastia de PMMA para reparar o defeito ósseo, foi altamente eficaz em reduzir essa complicação, com praticamente nenhum vazamento externo ou pseudomeningocele observado. Essa abordagem inovadora oferece resultados promissores para pacientes e neurocirurgiões, aumentando a segurança e melhorando os desfechos pós-operatórios.
🇧🇷 traduzidoTransdural Cisternotomy in the Extended Middle Fossa Approach.
Este artigo descreve a "cisternotomia transdural", uma nova técnica cirúrgica para abordagens na base do crânio (como as EMFAs) frequentemente usadas para tumores como meningiomas. As cirurgias convencionais podem causar inchaço cerebral, dificultando o procedimento e aumentando riscos para o paciente. A técnica inovadora drena precocemente o líquido cefalorraquidiano, promovendo um relaxamento cerebral significativo. Isso facilita a remoção completa do tumor e reduz o risco de complicações pós-operatórias, oferecendo um método eficaz e reprodutível que melhora os resultados para os pacientes e a segurança para os médicos.
🇧🇷 traduzidoTrigeminal Neurosarcoidosis as a Neurosurgical Dilemma: A Literature Review and Illustrative Case.
Este artigo destaca que a neurosarcoidose trigeminal isolada (TNS) é uma condição rara que, radiologicamente, mimetiza tumores comuns como schwannoma ou meningioma, criando um desafio diagnóstico significativo para médicos. Para pacientes e médicos, é crucial saber que a biópsia de tecido é indispensável para o diagnóstico definitivo, e a cirurgia, quando necessária, deve ser limitada à coleta da biópsia ou ressecção parcial para minimizar a morbidade, sendo o tratamento médico a abordagem principal após a confirmação.
🇧🇷 traduzidoPublicações recentes
Primary Dural-based diffuse large B-cell lymphoma mimicking meningioma in the olfactory groove: An unique case report and brief review of the literature.
An oculoplastic perspective on Transorbital Neuroendoscopic Surgery: Anatomical corridors and clinical applications.
Systemic therapy in the treatment of recurrent or refractory intracranial meningiomas: A systematic review and individual patient data meta-analysis.
Sexual assault by a gynecologist with two frontal lobe meningiomas: implications and challenges for forensic psychiatric assessment: a case report.
Middle ear lymphoepithelioma-like carcinoma with cerebellopontine angle invasion misdiagnosed as meningioma: A case report and literature review.
📚 EuropePMC11.487 artigos no totalmostrando 196
Diagnostic yield from minimally invasive pediatric brain tumor biopsies in the molecular era.
Journal of neurosurgery. PediatricsMolecularly distinct collision tumor consisting of meningothelial meningioma and glioblastoma, IDH-wildtype: illustrative case.
Journal of neurosurgery. Case lessonsRisk factors for nonresolving neurological deficits after spinal meningioma surgery: an integrated clinical and volumetric analysis of 202 patients.
Journal of neurosurgery. SpineExtracranial metastasis in histologically benign meningiomas: unpredictable behavior in WHO grade 1 tumors. Illustrative cases.
Journal of neurosurgery. Case lessonsFrontotemporal-orbitozygomatic approach for pediatric cranio-orbital tumors: a single-center experience.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryThe Causal Role of Circulating Inflammatory Cytokines in Brain Tumors: Insights from Genetic Epidemiology.
Immunological investigationsSolitary intracranial dural-based Ewing's sarcoma in a pregnant female: A case report.
Radiology case reportsEfficacy of a Novel Dimeric Macrocyclic Gadolinium Chelate With High Relaxivity in Preclinical Models of Neurological and Oncological Pathologies.
Investigative radiologyFrench translation and preliminary psychometric evaluation of the Meningioma Quality of Life questionnaire (MQOL-FR).
Neuro-ChirurgieHomologous recombination repair germline variants and subsequent neoplasm risk among childhood cancer survivors.
JNCI cancer spectrumA systematic review and meta-analysis of outcomes following active surveillance, surgery and radiotherapy of meningiomas in NF2-related schwannomatosis.
Neuro-oncology advancesPeritumoral Cystic Meningioma With Diagnostic Challenges: Two Case Reports and a Literature Review.
CureusAdvances in molecular and genetic profiling of meningiomas for improved diagnosis, prognosis, and targeted therapy.
Frontiers in oncologyProfiling of rare immune cell populations and integrative analysis identify immune ecotypes in newly diagnosed meningiomas.
Acta neuropathologica communicationsMicrosurgical Resection of an Atrium Meningioma via the Posterior Interhemispheric Transparieto-Occipital Fissure Approach: 2-Dimensional Operative Video.
Operative neurosurgery (Hagerstown, Md.)Network connectome analysis of multi omics data identifies molecular markers of recurrence and grade progression in meningioma.
Frontiers in oncologyAI-driven label-free Raman spectromics for intraoperative spinal tumor assessment.
NPJ digital medicineRegulatory mechanisms and functional analysis of cellular senescence-associated genes GAPDH, CCND1, and HBEGF in the immune microenvironment of meningioma.
BMC cancerPrimary pulmonary meningioma: a case report and literature review.
International journal of surgery case reportsEpigenetic buffering of proteotoxic stress by EHMT2 enables meningioma growth.
Neuro-oncology advancesNeuroendocrine Tumor of the Cauda Equina: A Report of a Rare Case With Histopathological and Immunohistochemical Correlation.
CureusSurgical management of petrous apex lesions: a descriptive analysis of outcomes by anatomical location for the Kawase, retrosigmoid, and pterional approaches.
Frontiers in neurologyRole of 68Ga-DOTA-TOC PET/CT in the Evaluation of Meningiomas with Osseous Involvement.
JPMA. The Journal of the Pakistan Medical AssociationDifferentiation of Intracranial Dural Metastases and Meningiomas Using DSC Perfusion MRI and Machine Learning.
Diagnostics (Basel, Switzerland)IgG4-Related Disease Manifested as Hypertrophic Pachymeningitis: A Case Report and Literature Review.
Diagnostics (Basel, Switzerland)Chopsticks mononostril approach with sphenoid sinus cranialization and septal mucosa suturing: a new minimally invasive concept and closure technique for endoscopic endonasal approaches.
Journal of neurosurgeryThe "O-Ring" technique is effective in reducing cerebrospinal fluid leak in posterior fossa surgery.
Journal of neurosurgical sciencesIn Vivo Hyperspectral Imaging of Vasogenic Edema and Cortical Oxygenation in Meningiomas: A Subgroup Interim Analysis of a Prospective Study.
NeurosurgeryA multi-model fusion approach incorporating conventional radiological and machine learning features across age spectrum for periorbital fat status prediction.
Frontiers in medicineRecurrent Primary Extracranial Meningioma: A Case Report and Literature Review of a Rare Scalp Tumor.
CureusFluorescence-guided surgery combined with intraoperative photodynamic therapy for recurrent atypical and anaplastic intracranial meningiomas: a prospective feasibility study.
Frontiers in oncologyFrom sunburst to mother-in-law sign in intracranial meningioma: a matter of time.
Acta neurologica BelgicaAssociations of surgical menopause and hormone replacement therapy with meningioma development.
Journal of neuro-oncologySpheno-Orbital Meningioma With an Orbital Cystic Component.
Ophthalmic plastic and reconstructive surgeryTransdural Cisternotomy in the Extended Middle Fossa Approach.
Neurology IndiaTrigeminal Neurosarcoidosis as a Neurosurgical Dilemma: A Literature Review and Illustrative Case.
Neurology IndiaA case of trigeminal nerve neurosarcoidosis initially presenting with isolated neurological findings mimicking trigeminal schwannoma: a case report and review of the literature.
Journal of medical case reportsLaser interstitial thermal therapy for intracranial dural-based lesions: A single center case series of 20 patients.
Clinical neurology and neurosurgeryOlfactory Groove Meningioma Presenting With Visual Decline and Gait Disturbance: A Case Report.
CureusEfficient attention-based Ghost-ResNet for brain tumor classification in magnetic resonance imaging (MRI).
Frontiers in neuroscienceStereotactic radiosurgery (SRS) for primary intradural spinal tumors: A systematic review and meta-analysis.
Neurosurgical reviewA Rare Case of Pulmonary Metastasis From Intracranial Grade 2 Meningioma.
CureusHybrid Aquila optimizer-Harris Hawks optimization for CNN hyperparameter tuning in brain tumor classification.
Scientific reportsLong-term relief of refractory trigeminal neuropathy using high-frequency spinal cord stimulation at the cervicomedullary junction: a 6-year follow-up case report.
Frontiers in neuroscienceMolecular mechanisms and therapeutic targeting implications of ER/mTOR signaling axis-driven tumor progression in aggressive meningiomas.
Translational oncologyInvestigating the clinical significance of systemic inflammatory indices for post-treatment peritumoral edema after gamma knife radiosurgery for meningioma.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of AustralasiaTranslation and Validation of the Neurologic Assessment in Neuro-Oncology Scale into Indonesian (NANO-Ina).
Asian Pacific journal of cancer prevention : APJCPPrognostic stratification of chordoid meningiomas: the role of chromosome 1p/22q Loss.
Acta neuropathologica communications3D digital exoscope is safe tool in the surgery of olfactory groove meningiomas.
Acta neurochirurgicaDiagnostic value of cellular inflammatory markers in CNS tumor patients undergoing glucocorticoid therapy.
Frontiers in oncology[The role of histopathology in the diagnosis and management of intracranial meningiomas. Hospital experience in Kinshasa (Democratic Republic of Congo)].
Medecine tropicale et sante internationaleVariances in 3D radiomic shape features between meningioma, acoustic neuroma, and pituitary adenoma and the impact on dosimetric plan quality in Gamma Knife stereotactic radiosurgery.
Biomedical physics & engineering expressPosterolateral Approach for Recurrent multi-level Ventral Intradural Extramedullary Cervical Spinal Meningioma.
Turkish neurosurgeryBlindness after middle meningeal artery embolization for skull metastasis of follicular thyroid carcinoma with ophthalmic artery variant.
Surgical neurology internationalElderly patient with a calcified upper cervical meningioma acutely worsened by head trauma.
Surgical neurology internationalMultilayer dural repair using absorbable artificial dura in the posterior fossa: A case report on the "sandwich technique".
Surgical neurology internationalCavernous sinus meningiomas: A retrospective study of natural history, growth dynamics, and treatment response over two decades.
Surgical neurology internationalSpontaneous Regression of Meningiomas: Literature Review and Case Report.
Asian journal of neurosurgeryA single MRI scan contains sufficient imaging information for accurate prediction of meningioma growth risk.
NeuroImage. ClinicalDrug screening on tumor organoids exposes therapeutic vulnerabilities of meningiomas to HDAC1/2i panobinostat.
Science translational medicineBrief results of heterotopic xenotransplantation of meningioma into the peritoneum of Wistar rats: an experimental study.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicasThe "Trimeric" Anterolateral Thigh Free Flap: A Novel Technique for the Reconstruction of Complex Cranio-Orbital and Middle Skull Base Defects.
Operative neurosurgery (Hagerstown, Md.)Diagnostic Challenge of a Tumor-mimicking Spinal Pseudogout Lesion: Case Report and Literature Review.
Cancer diagnosis & prognosis[Pediatric parasagittal meningioma, case report].
Revista medica del Instituto Mexicano del Seguro SocialSpectrum of non-ischemic oculomotor nerve palsies at a tertiary care centre - case series and literature review.
StrabismusDiffuse pulmonary meningotheliomatosis in resected lung adenocarcinoma: a rare incidental finding.
BMJ case reportsLung Metastases from Meningioma Diagnosed on Whole Body 68Ga-DOTATOC PET/CT and Successfully Targeted With 177Lu-DOTATATE.
Clinical nuclear medicineHuman Meningiomas Reveal No Evidence of Neuroendocrine Differentiation.
APMIS : acta pathologica, microbiologica, et immunologica ScandinavicaSingle-Stage Resection and Reconstruction of Intraosseous Meningioma: The First Reported Case at Our Hospital.
CureusCurrent landscape of single-cell genomics in meningioma.
Neuro-oncology advancesVoxel-based spatial distribution of intracranial meningioma subtypes and their relationship to radiogenomic maps.
Brain communicationsContrast-Enhanced Vessel Wall Imaging in Determining Angioplasty Suitability for Radiation-Induced Stenosis: A Case Report.
Journal of UOEHUnusual immunohistochemical profiles in hemangioblastomas and their relevance in differential diagnosis: A comprehensive study of 112 cases.
Journal of neuropathology and experimental neurologyInduction of Meningioma Stem Signature via Hydrogel Reprogramming and Application of Meningioma Stem Cell Marker CXCR4 to Pathological Diagnosis and Treatment.
Biotechnology and bioengineeringPrimary Dural Diffuse Large B-Cell Lymphoma: A Report of a Rare Case and Review of the Literature.
CureusDistant Metastases of an Atypical Meningioma 14 Years Later After Primary Tumor Resection: A Case Report and Review of the Literature.
Case reports in pathologyTwo-Week Interval Hypofractionated Stereotactic Radiosurgery for Benign Intracranial Tumors: Volumetric Kinetics and Radiobiological Rationale.
CancersA Robust ConvNeXt-Based Framework for Efficient, Generalizable, and Explainable Brain Tumor Classification on MRI.
Bioengineering (Basel, Switzerland)An Evaluation Study of PET Image Quality Factors in Brain Tumor Diagnosis.
Tomography (Ann Arbor, Mich.)Minimally Invasive Surgical Strategies in Intraventricular Tumors: Preliminary Experience with Tubular Retractors for a Personalized Approach in Intraventricular Meningiomas.
Journal of personalized medicineResection of the Clinoidal meningioma Encasing the Carotid Artery: A Complex and Delicate Surgical Procedure.
World neurosurgeryLate-onset vascular and tumor complications after childhood brain radiotherapy: A rare case of dual sequelae.
Radiology case reportsProgestogen use and the risk of intracranial meningioma: a systematic review and meta-analysis.
EClinicalMedicineSingle-Fraction Stereotactic Radiosurgery for Benign Perioptic Meningiomas: A Strategy for Long-Term Tumor Control and Radiation-Induced Optic Neuropathy Avoidance With a 10-Year Follow-up.
Journal of Korean medical science[68Ga]-DOTATATE PET SUV Reduction After Bevacizumab in High-Grade Meningioma: A Potential Treatment Response Biomarker.
AJNR. American journal of neuroradiologyMask - Region-based Convolutional Neural Networks (R-CNN) with Radiomics Integration and Gray Level Co-occurrence Matrix (GLCM) for brain tumor detection and segmentation.
PloS oneA Two-way Mendelian randomisation study of inflammatory factors and the risk of meningioma.
Translational neuroscienceExoscopic Resection of an Olfactory Groove Meningioma Through an Anterior Interhemispheric Approach.
World neurosurgeryGlucagon-like peptide-1 receptor agonists and the risk of obesity-related cancers: a systematic review and meta-analysis.
Diabetes research and clinical practiceDiagnostic Performance of Microstructural Parameters Derived From Time-dependent Diffusion MRI for Grading Meningiomas: A Prospective Study.
Academic radiologyGadolinium-Enhanced Portable Ultra-Low Field MRI for Evaluating Various Intracranial Pathologies.
AJNR. American journal of neuroradiologyHypofractionated palliative-intent radiation therapy for a postsurgical recurrent grade II cervical spinal meningioma in a dog.
The Canadian veterinary journal = La revue veterinaire canadienneAn unusual facial location for a meningioma. Case report.
Journal of clinical and experimental dentistryClinicopathological significance of loss of Y chromosome in male meningiomas.
The Journal of pathologyHybrid deep neural network with PCA based features optimization for enhancing brain tumor classification.
Scientific reportsMeningioma-like inflammatory myofibroblastic tumor of the lung with TPM3::ALK fusion.
Virchows Archiv : an international journal of pathologyPeritumoral edema in meningiomas: a review of influencing factors, mechanisms, and management.
Frontiers in oncology[Future Perspectives of Middle Meningeal Artery Embolization for Meningioma and Chronic Subdural Hematoma].
No shinkei geka. Neurological surgeryIncidence of meningioma in women with a history of combined oral contraceptive pill use and polycystic ovary syndrome.
Women's health (London, England)Meningioma theranostics: a retrospective analysis of somatostatin receptor PET/CT imaging and peptide receptor radionuclide therapy.
European journal of nuclear medicine and molecular imagingUtility of digital PCR for detecting TERT promoter mutations and CDKN2A homozygous deletion in meningioma.
Brain tumor pathologyBrain tumor classification using optimized ResNet50 with dynamic precision optimization for enhanced speed and diagnostic accuracy.
Scientific reportsOptic nerve sheath meningiomas harbor distinct genetic variants.
American journal of clinical pathologyDiabetes prolongs hospitalization and increases infection, cerebral edema, and neurological complications in meningioma patients: A retrospective study.
World journal of diabetesClinical characteristics of petroclival meningioma and the impact of resection degree on its prognosis.
Frontiers in neurologyCase Report: Meningioma with unusual extracranial extension to the temple and orbit.
Frontiers in oncologyA schwannoma of the olfactory nerve: a case report of a diagnostic challenge and review of the literature.
Journal of surgical case reportsSomatostatin receptor PET in meningioma: diagnosis, therapy, and surveillance.
Nuclear medicine communicationsTiming of adjuvant radiotherapy impacts overall survival for atypical intracranial meningiomas: a National Cancer Database (NCDB) analysis.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of AustralasiaMRI and Meningioma Research: Hotspots and Trends via Bibliometric Analysis.
Current medical imagingDeciding when and when not to reconstruct the orbit: How I do it.
Acta neurochirurgicaDefinitive embolization of meningiomas: a 20-year updated systematic review.
Journal of neurointerventional surgerySpinal extradural meningioma mimicking lumbar disc herniation in a cat: a case report.
BMC veterinary researchBoron Neutron Capture Therapy: A Technology-Driven Renaissance.
CancersOptimal α/β Ratio for Biologically Effective Dose-Based Prediction of Radiation-Induced Peritumoral Brain Edema in Meningioma.
CancersSTING activation induces cytotoxic and immune responses in meningiomas via inflammatory cell death pathways.
Nature communicationsT2-Weighted MRI Signal Intensity Ratio Predicts Intraoperative Intracranial Meningioma Consistency: A Retrospective Cohort Study.
NeurosurgeryIntegrated Clinical Genetic Analysis Reveals Transcriptional Neurotransmitter Receptor Dysregulation in Meningiomas Causing Seizure.
NeurosurgeryMendelian randomization identifies the characteristic plasma metabolite profile of meningioma.
Archives of medical science : AMSCrista Galli Pneumatization Complicating Olfactory Groove Meningioma Resection: A Case Report.
CureusA 6-year-old boy with left temporal lobe mass.
Brain pathology (Zurich, Switzerland)Perfusion changes associated with intratumoral embolization and feeder occlusion for meningiomas: an arterial spin labeling study.
Acta neurochirurgicaThe prognostic impact of CDKN2A/B hemizygous deletions in meningioma.
Neuro-oncologyHigh frequency and unique subtypes of meningioma in patients with BAP1 tumor predisposition syndrome.
Journal of neuro-oncologyEnhancing cancer prognostics with group penalty models: a comparative study on radiomics feature selection in lung adenocarcinomas and meningiomas.
Quantitative imaging in medicine and surgery[Tentorial meningiomas extending along transverse and sigmoid sinuses to jugular vein bulb].
Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko[Posterior petrous meningiomas: clinical manifestations, anatomical relationships and postoperative outcomes].
Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko[Postoperative complications following resection of extramedullary tumors of the craniovertebral junction region].
Zhurnal voprosy neirokhirurgii imeni N. N. BurdenkoOutcomes of Gamma Knife radiosurgery for meningiomas overlying the motor cortex.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of AustralasiaCausal Pathways Linking Gut Microbiota, Serum Metabolites, and Meningioma Risk: A Mendelian Randomization Analysis.
Brain and behaviorUnlocking the full potential of MRI with artificial intelligence for pre-operative meningioma evaluation.
European radiologyStromal immune cell signatures predict risk of progression in meningioma.
Nature geneticsA microenvironment-determined risk continuum refines subtyping in meningioma and reveals determinants of machine learning-based tumor classification.
Nature geneticsFacial Nerve Outcomes Following Microsurgical Resection of Large Cerebellopontine Angle Tumors: Experience From a Tertiary Care Center in Pakistan.
Brain tumor research and treatmentFractionated radiotherapy adjuvant to surgery of WHO-2 meningioma with and without gross total resection: a multicenter, retrospective cohort study of 1,452 patients.
Journal of neuro-oncologyStandalone Meningioma Embolization: A Systematic Review.
NeurosurgeryVoxel-Based Mapping of Seizure Risk in Meningioma Identifies the Frontoparietal Interface and Tumor Microenvironment as Key Predictors.
NeurosurgeryAmbient Air Pollution and Risk of Brain Tumors: A Systematic Review and Meta-Analysis.
Asian Pacific journal of cancer prevention : APJCPCryptococcal dumbbell inflammatory pseudotumor mimicking skull histiocytic sarcoma in immunocompetent patient.
Surgical neurology internationalRadiation-induced meningiomas: A systematic review and meta-analysis of 927 meningiomas.
Surgical neurology internationalMicrosurgical resection of a primary mixed intramedullary-extramedullary thoracic meningeal melanoma.
Surgical neurology internationalBTdiagAI: A Web-Deployed Hybrid Framework for Brain Tumor Classification Using Optimized MRI Preprocessing and Deep Learning Fusion.
Healthcare technology lettersRe: Intracranial primary collision tumours: A comprehensive systematic review on preoperative radiological accuracy and neuro-oncological insights. Brain Spine 2026: 105943.
Brain & spineRadioligand therapy for primary brain tumors: a PRISMA-based systematic review of meningiomas and gliomas.
Frontiers in medicineSafety profile of progesterone: Insights from an FDA Adverse Event Reporting System (FAERS)-based pharmacovigilance study.
The Journal of international medical researchAssociation Between miRNAs and the Diagnosis, Prognosis, and Recurrence of Patients with Meningioma: A Systematic Review.
Cellular and molecular neurobiologyPredictive factors in spinal meningiomas - a comparative analysis with intracranial meningiomas of a high-volume skull and base center.
Neurosurgical reviewThe effect of modified head-of-bed elevation on postoperative headache and CSF leakage after meningioma resection.
MedicineIntrasellar meningioma versus pituitary apoplexy in the setting of postpartum hemorrhage: a case report.
BMC pregnancy and childbirthBRISC: Annotated Dataset for Brain Tumor Segmentation and Classification.
Scientific dataMechanical instability as a signature of viscoelastic decoupling at the tumor-brain interface.
Biomaterials advancesKMT2C Loss Promotes NF2-Wildtype Meningioma Progression and Ferroptosis Sensitivity via Epigenetic Repression of Hippo Signaling.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)Extracranial meningioma of the masticator space: a rare case report.
NeuroradiologyReliable and Accurate Differentiation of Optic Perineuritis and Optic Nerve Sheath Meningioma from the Radiologists' Perspective.
Neuro-ophthalmology (Aeolus Press)Brain MRI Radiomic First-Order Features for Presurgical Prediction of Meningioma Grading.
Journal of neuroimaging : official journal of the American Society of NeuroimagingFOXC1 expression and radiological predictors of peritumoral brain edema in meningiomas.
Journal of neuro-oncologyMeningioma microenvironment harbors a rich immune landscape that evolves with biological state.
Neuro-oncologyMolecular classification of radiation-induced meningiomas.
International journal of radiation biologyAssociation of thyroid disease and intracranial meningiomas: a retrospective analysis with external validation.
Frontiers in oncologyThe mini-pretemporal approach for skull base neoplasms: A technical note.
Surgical neurology internationalGiant skull base meningiomas: Definitions, case reports, and surgical approaches.
Surgical neurology internationalSurgical Treatment of Meningioma with Situs Inversus Totalis Assisted by 3D Technology: A Case Report.
Current medical imagingOptic nerve sheath meningioma exhibits neural niche-associated transcriptomic features and rare copy number variation-linked evolution.
Brain pathology (Zurich, Switzerland)Gamma knife radiosurgery for meningiomas: a bibliometric analysis and single-center clinical trend study.
Neurosurgical reviewSenogenic-senolytic treatment strategies enhance tumor control and can improve survival in murine cancer models: a systematic review.
BMC cancerPretemporal Transcavernous Approach to Cavernous Sinus Meningioma with Suprasellar Extension Synchronous with Sphenoid Wing Meningioma: Operative Technique: 2-Dimensional Operative Video.
World neurosurgeryCutting-edge approaches in pet imaging for gliomas: current applications for neurooncologists and the path to theranostic breakthroughs.
European journal of nuclear medicine and molecular imagingEXPRESS: Surgical treatment of feline meningioma: a single institution survival analysis.
Journal of feline medicine and surgery[Ga68]DOTATATE PET in Schwannomas: Distinct Avidity Pattern Supporting Noninvasive Diagnosis.
AJNR. American journal of neuroradiologyCase Report: Pathological confirmation and aggressive postoperative recurrence of WHO grade III rhabdoid meningioma.
Frontiers in medicineA case of radiation treatment effect mimicking viable, recurrent meningioma on DOTATATE PET imaging.
Neuro-oncology advancesExploring the Causal Links Between Toxoplasma gondii Infection and Risk of Brain Tumors: A Bidirectional Mendelian Randomization Analysis.
Brain and behaviorRetrospective Analysis of Epidemiology of Intracranial and Spinal Tumor in North Western Part of India: 5-Year Observational Study of 1315 Cases.
CureusPeroxisome Proliferator-Activated Receptor (PPAR) Expression Correlates With Tumor Grade and Prognostic Outcome in Meningiomas.
Applied immunohistochemistry & molecular morphology : AIMMAn efficient 3D latent diffusion model for T1-contrast enhanced MRI generation.
Biomedical physics & engineering expressCase Report: Intracranial hemophilic pseudotumor mimicking an aggressive neoplasm: a rare skull-invasive presentation.
Frontiers in surgeryRadioligand Therapy in Meningiomas: Today's Evidence, Tomorrow's Possibilities.
CancersSyringomyelia in the Course of Resection of Foramen Magnum Pathology: A Case Report with an Intriguing Therapeutic Solution and Systematic Review.
Brain sciencesIntra-Arterial Radioligand Therapy in Brain Cancer: Bridging Nuclear Medicine and Interventional Neuroradiology.
Diagnostics (Basel, Switzerland)Giant Right Sphenoid Wing Meningioma as a Reversible Frontal Network Lesion: A Pseudo-bvFTD Case with Venous-Sparing Skull-Base Resection.
Diagnostics (Basel, Switzerland)Multi-class classification of brain tumors using optimized CNN and transfer learning techniques.
Scientific reportsThe 2024 Brain Tumor Segmentation Challenge Meningioma Radiotherapy (BraTS-MEN-RT) dataset.
Scientific dataMalignant Progression of Subependymal Giant Cell Astrocytoma-Imitating Fibrous Meningioma in a Child Carrying a Germline <italic>CHEK2</italic> Mutation.
Pathobiology : journal of immunopathology, molecular and cellular biologyPrognostic significance of H3.K27me3 loss in CNS WHO grade 2 meningiomas: a multicentre clinicopathological study.
Journal of neuro-oncologyCytologic and Histological Features Distinguishing Myxoid Meningioma From Chordoid Meningioma: A Case Report.
Diagnostic cytopathologyIntracranial primary collision tumours: A comprehensive systematic review on preoperative radiological accuracy and neuro-oncological insights.
Brain & spineExplainable AI-driven MRI-based brain tumor classification: a novel deep learning approach.
Frontiers in artificial intelligenceDeficiency of SMARCB1 drives an immunosuppressive microenvironment in meningioma.
Acta neuropathologica communicationsExplainable Hybrid Deep Learning Framework Integrating MobileNetV2, EfficientNetV2B0, and KNN for MRI-Based Brain Tumor Classification.
Cellular and molecular neurobiologyA scoping review of artificial intelligence applications in meningioma from image analysis to prognostic prediction.
Discover oncologyEfficacy of azacitidine in meningiomas and explorative analyses of underlying molecular mechanisms.
Neurosurgical reviewHigh intra-tumoral and serum matrix metalloproteinase 9 levels are associated with reduced survival of patients with glioblastoma and brain metastases.
Frontiers in oncologyEndoscopic Endonasal Approach for Primary Optic Nerve Sheath Meningioma: A Systematic Review.
World neurosurgeryDistant metastasis of intracranial solitary fibrous tumor preceding resection: illustrative case.
Journal of neurosurgery. Case lessonsOlfactory groove meningioma presenting solely with visual impairment: illustrative case.
Journal of neurosurgery. Case lessonsGlioblastoma eroding through falx cerebri: a rarity or commonly seen? Illustrative case.
Journal of neurosurgery. Case lessonsAssociações
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Diagnostic yield from minimally invasive pediatric brain tumor biopsies in the molecular era.
- Surgical management of petrous apex lesions: a descriptive analysis of outcomes by anatomical location for the Kawase, retrosigmoid, and pterional approaches.
- The "O-Ring" technique is effective in reducing cerebrospinal fluid leak in posterior fossa surgery.
- Transdural Cisternotomy in the Extended Middle Fossa Approach.
- Trigeminal Neurosarcoidosis as a Neurosurgical Dilemma: A Literature Review and Illustrative Case.
- Primary Dural-based diffuse large B-cell lymphoma mimicking meningioma in the olfactory groove: An unique case report and brief review of the literature.
- An oculoplastic perspective on Transorbital Neuroendoscopic Surgery: Anatomical corridors and clinical applications.
- Systemic therapy in the treatment of recurrent or refractory intracranial meningiomas: A systematic review and individual patient data meta-analysis.
- Sexual assault by a gynecologist with two frontal lobe meningiomas: implications and challenges for forensic psychiatric assessment: a case report.
- Middle ear lymphoepithelioma-like carcinoma with cerebellopontine angle invasion misdiagnosed as meningioma: A case report and literature review.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:2495(Orphanet)
- MONDO:0016642(MONDO)
- GARD:7015(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
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