Raras
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Deficiência de hormônio pituitário adquirida
ORPHA:95502DOENÇA RARA

Um caso de hipopituitarismo adquirido durante a vida do indivíduo.

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Um caso de hipopituitarismo adquirido durante a vida do indivíduo.

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Partes do corpo afetadas

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Crescimento
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Características mais comuns

Neuralgia trigeminal
Nível anormal de prolactina
Hipotireoidismo hipofisário
Hipotensão
Concentração elevada de hormônio do crescimento circulante
Diabetes mellitus tipo 1
105sintomas
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Os sintomas variam de pessoa para pessoa. Abaixo estão as 105 características clínicas mais associadas, ordenadas por frequência.

Neuralgia trigeminalTrigeminal neuralgia
Nível anormal de prolactinaAbnormal prolactin level
Hipotireoidismo hipofisárioPituitary hypothyroidism
HipotensãoHypotension
Concentração elevada de hormônio do crescimento circulanteElevated circulating growth hormone concentration

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Últimos 10 anos171publicações
Pico202419 papers
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20202015Hoje · 2026📈 2024Ano de pico🧪 2025Primeiro ensaio clínico
Publicações por ano (últimos 10 anos)

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Publicações mais relevantes

Timeline de publicações
0 papers (10 anos)
#1

Management of infertility in women with hypothalamic hypogonadotropic hypogonadism: an expert opinion.

Reproductive biology and endocrinology : RB&E2026 Feb 19

Hypothalamic gonadotropin-releasing hormone (GnRH) plays a central role in regulating the pituitary-gonadal axis. The pulsatility of GnRH release is critical for maintaining the function of GnRH receptors and the secretion pattern of gonadotropins, namely follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which regulate endocrine function and follicular growth and maturation. During the luteal phase, LH is crucial for supporting a functional corpus luteum and stimulating it to produce progesterone, estradiol and relaxin.Hypothalamic hypogonadotropic hypogonadism originates from a deficiency in GnRH secretion. Low circulating gonadotropin levels subsequently lead to reduced ovarian function and anovulation. This condition may be congenital or acquired, for example through functional hypothalamic amenorrhoea (FHA) or FHA combined with polycystic ovarian morphology (PCOM). Pulsatile GnRH therapy plays a pivotal role in restoring the physiological menstrual cycle and selecting a dominant follicle in these women, thereby inducing ovulation and achieving fertility. There is extensive literature accounting for a high ovulation rate and consequently high pregnancy and birth rates per cycle, with a lower risk of adverse outcomes. In this review, based on clinical evidence and published studies, we provide recommendations for the alternative treatment of infertility in women with congenital hypothalamic hypogonadotropic hypogonadism (CHH) and FHA (with or without PCOM), until pulsatile GnRH therapy becomes available again or in countries where this device is not marketed. Starting doses and adjustments should be made according to the aetiology of hypothalamic hypogonadotropic hypogonadism and other patient parameters. In all cases, luteal phase support is imperative and should ideally be provided by hCG injections to optimize corpus luteum functions. When pulsatile GnRH therapy is not available, and to ensure the effective treatment of female infertility due to FHA (with or without PCOS) or hypothalamic CHH, we advise physicians to optimise stimulation with exogenous gonadotropins according to the cause of hypothalamic hypogonadotropic hypogonadism. In all cases, providing luteal phase support by optimising corpus luteum function is mandatory.

#2

Acquired transient vasopressin deficiency by cannabinoids and other substances.

Endocrinology2026 Mar 06

Water movement across cell membranes through aquaporin water channels creates osmotic equilibrium between extracellular and intracellular fluid compartments. Plasma osmolality is tightly regulated by the kidneys and brain through the process of osmoregulation. The antidiuretic hormone, arginine vasopressin (AVP), is normally released from the posterior pituitary in response to increased osmolality or decreased intravascular volume. Defects in the synthesis or release of AVP result in AVP deficiency (AVP-D) and the syndrome of central diabetes insipidus, characterized by inappropriate aquaresis leading to hyperosmolality and insatiable thirst. While most cases of AVP-D are due to local mechanical, infiltrative, compressive, infectious, or inflammatory processes, some recreational and pharmacological substances can cause AVP-D. In this review, we discuss the history and current knowledge about these substances, including cannabinoids, ethanol, κ opioid receptor agonists, phenytoin, and anesthetic agents.

#3

GH Response to Glucagon in Transition: Role of BMI and Etiology in Childhood-Onset GH Deficiency.

The Journal of clinical endocrinology and metabolism2026 Jan 12

The glucagon stimulation test (GST) is increasingly used as an alternative to the insulin tolerance test for diagnosing persistent growth hormone (GH) deficiency during transition, though its accuracy and appropriate cutoff values are still uncertain. To investigate the GH response to GST in transitional-age patients with childhood-onset GHD (CO-GHD), with a focus on the influence of BMI and underlying etiology. A total of 180 patients with CO-GHD (median age 17.39 years) underwent GST. They were grouped based on the number of pituitary deficiencies and MRI findings into I-GHD (isolated, n=80), OM-GHD (1-2 deficiencies with congenital or acquired anomalies, n=63), and OS-GHD (≥3 deficiencies with complex CNS abnormalities, n=37). Additionally, patients were classified by BMI as normal weight, overweight, or obesity, according to age-appropriate BMI criteria. Childhood cancer survivors (CCS) accounted for 42% of the cohort. Peak GH response to GST showed a significant inverse association with the severity of pituitary dysfunction (p < 0.001) and an inverse correlation with BMI SDS (ρ = -0.46, p < 0.001). However, adjusting by disease group strongly reduced the impact of BMI on the GST response. When stratified by etiology or CCS status, GH peaks were primarily influenced by hypothalamic-pituitary damage with BMI showing a minimal effect. The GST provides valuable insights into GH deficiency in transitional-age patients with CO-GHD. GH response is primarily influenced by the severity of pituitary dysfunction, with BMI playing a minimal role once adjusted for etiology.

#4

Hypoprolactinemia: Biology, Clinical Relevance, and Diagnostic Challenges.

Clinical endocrinology2026 Mar

Prolactin (PRL) is a pleiotropic hormone, traditionally associated with lactation, but now recognised for its role in reproduction, metabolism, and neuroendocrine and immune regulation. While the clinical features and consequences of hyperprolactinemia are well known, hypoprolactinemia is poorly understood. The causes of PRL deficiency range from genetic mutation to acquired pituitary diseases and rare isolated disorders. Its diagnostic evaluation is often challenging, due to the lack of standardised lower reference limits. Nonetheless, growing evidence links hypoprolactinemia not only to postpartum agalactia, but also to reproductive and sexual dysfunction, and to metabolic alterations and increased cardiometabolic risk. Data from animal models and rare human cases further suggest that PRL exerts unique biological functions that are not fully compensated by other pituitary hormones. PRL measurement, when interpreted alongside gonadotropin levels and clinical context, may help in the differential diagnosis of secondary amenorrhoea. Markedly low PRL levels-especially in association with hypogonadotropic profiles-may support a diagnosis of functional hypothalamic amenorrhoea. PRL should be recognised as a hormone whose deficiency may cause broader systemic disturbances. A comprehensive understanding of hypoprolactinemia is essential to better define its diagnostic criteria and clinical significance.

#5

Impact of traumatic brain injury severity on anterior pituitary function: A prospective study.

Clinical neurology and neurosurgery2025 Nov

India experiences the highest number of road traffic fatalities globally. Acquired hypopituitarism is a common sequela in patients who sustain traumatic brain injury (TBI). This study aimed to investigate the prevalence and imaging characteristics of hypopituitarism in patients with TBI at a tertiary care centre in North India. Our prospective study included 76 patients with TBI (mild, moderate, or severe), whom we followed for 24 weeks at a tertiary care centre in North India. All included subjects underwent assessments of anterior pituitary hormones (LH, FSH, TSH, T4, cortisol, testosterone, estrogen) at baseline and again at 24 weeks, as well as an MRI. Those who had low cortisol level were subjected to glucagon stimulation test and cortisol and growth hormone was measured after stimulation in these subjects. We recorded the severity of traumatic brain injury, findings from CT scans such as skull fractures, and imaging characteristics of pituitary gland in all the patients by magnetic resonance imaging (MRI). Appropriate statistical analyses, including logistic regression, were utilized to determine the determinants of hypopituitarism. Among the 76 patients, the prevalence of hypopituitarism was 11.84 % in the acute stage and 2.63 % at 24 weeks. Hypopituitarism significantly correlated with injury severity (p < 0.001) and imaging abnormalities observed on MRI. The main imaging findings on MRI were heterogeneous signal intensity, subacute haemorrhage in the anterior pituitary, and reduced pituitary height. A statistically significant decrease was observed in LH (p = 0.009) and FSH levels (p = 0.039) from baseline to 24 weeks. The severity of the injury and the presence of base skull fractures were significantly associated with hypopituitarism (p < 0.001). Our results highlight the importance of checking pituitary function in TBI patients, particularly those with moderate to severe injuries and skull base fractures, to quickly find and treat hormonal deficiencies, which can improve long-term results. Future studies should concentrate on longer follow-up periods and more sophisticated imaging methods to gain a more profound understanding of the mechanisms underlying post-traumatic hypopituitarism.

Publicações recentes

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📚 EuropePMCmostrando 166

2026

Management of infertility in women with hypothalamic hypogonadotropic hypogonadism: an expert opinion.

Reproductive biology and endocrinology : RB&amp;E
2026

Acquired transient vasopressin deficiency by cannabinoids and other substances.

Endocrinology
2026

GH Response to Glucagon in Transition: Role of BMI and Etiology in Childhood-Onset GH Deficiency.

The Journal of clinical endocrinology and metabolism
2026

Hypoprolactinemia: Biology, Clinical Relevance, and Diagnostic Challenges.

Clinical endocrinology
2025

Primary adrenocortical insufficiency in patients with AIDS in Wuhan, China: 3 cases report and literature review.

BMC infectious diseases
2025

Determinants of QTc Interval Prolongation in Patients with Hypopituitarism and Other Pituitary Disorders.

Biomedicines
2025

Exploring GHBP as a surrogate of GH activity in multimorbid older adults: A cross-sectional study.

Growth hormone &amp; IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
2025

Patients with langerhans cell histiocytosis and hypothalamic-pituitary involvement: insights from the HEROS study cohort.

Pituitary
2025

Growth hormone deficiency after moderate traumatic brain injury with normal (or high) IGF-1; a case report demonstrating benefit of replacement therapy and clinical pearls for diagnosis.

The Clinical neuropsychologist
2025

Impact of traumatic brain injury severity on anterior pituitary function: A prospective study.

Clinical neurology and neurosurgery
2025

Management of acromegaly beyond primary surgery: efficacy and safety of repeat surgery and radiotherapy.

Acta neurochirurgica
2025

A Genetically-Engineered Thyroid Gland Built for Selective Triiodothyronine Secretion.

International journal of molecular sciences
2025

QT Prolongation and Torsades De Pointes Due to Undiagnosed Sheehan Syndrome: A Rare Cause of Lethal Arrhythmia.

Cureus
2025

Hypopituitarism: genetic, developmental, and acquired etiologies with a focus on the emerging concept of autoimmune hypophysitis.

Endocrine journal
2025

Isolated adrenocorticotrophic hormone (ACTH) deficiency presenting with recurrent hypoglycemia and hyponatremia.

Annals of medicine and surgery (2012)
2025

Pituitary dysfunction after cranial radiotherapy for brain tumor.

Annales d'endocrinologie
2025

Central Hypothyroidism: Advances in Etiology, Diagnostic Challenges, Therapeutic Targets, and Associated Risks.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
2025

Growth hormone signaling and clinical implications: from molecular to therapeutic perspectives.

Molecular biology reports
2024

Clinical and genetic features of childhood-onset congenital combined pituitary hormone deficiency: a retrospective, single-center cohort study.

Annals of pediatric endocrinology &amp; metabolism
2025

Central Adrenal Insufficiency: Etiology and Diagnostic Approach.

Journal of clinical research in pediatric endocrinology
2024

What Is Hidden Behind Growth Hormone Deficiency? The Neuroradiologist's Perspective.

Frontiers of hormone research
2024

A Case of Idiopathic Central Diabetes Insipidus and a Mosaic Form of Turner Syndrome.

Cureus
2024

An Update on Advances in Hypopituitarism: Etiology, Diagnosis, and Current Management.

Journal of clinical medicine
2024

The molecular basis of hypoprolactinaemia.

Reviews in endocrine &amp; metabolic disorders
2024

Acquired isolated ACTH deficiency co-occurrence with breast cancer irrespective of paraneoplastic syndrome: coincidence or inevitability.

Endocrinology, diabetes &amp; metabolism case reports
2024

Isolated hypoprolactinemia: The rarest of the rare?

Reviews in endocrine &amp; metabolic disorders
2024

Acquired hypoprolactinemia in men, possible phenotype.

Reviews in endocrine &amp; metabolic disorders
2024

Acquired thyroid-stimulating hormone, luteinizing hormone, and follicle-stimulating hormone deficiencies with circulating anti-glycoprotein hormones alpha chain-positive cell antibodies.

Endocrine
2024

The somatotroph pituitary gland function in high-aged multimorbid hospitalized patients with IGF-I deficiency.

Pituitary
2024

Long-term pituitary function and functional and patient-reported outcomes in severe acquired brain injury.

European journal of endocrinology
2025

Acquiring Social Safety Engages Oxytocin Neurons in the Supraoptic Nucleus: Role of Magel2 Deficiency.

Neuroendocrinology
2024

Diagnosis and management of congenital hypopituitarism in children.

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
2024

Position statement on the diagnosis and management of congenital pituitary deficiency in adults: The French National Diagnosis and Treatment Protocol (NDTP).

Annales d'endocrinologie
2024

Insights from an advisory board: Facilitating transition of care into adulthood in brain cancer survivors with acquired pediatric growth hormone deficiency.

Growth hormone &amp; IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
2024

Subclinical central hypothyroidism in patients with hypothalamic-pituitary disease: does it exist?

Reviews in endocrine &amp; metabolic disorders
2024

Idiopathic isolated adrenocorticotropic hormone deficiency: a systematic review of a heterogeneous and underreported disease.

Pituitary
2024

Diagnosing and treating anterior pituitary hormone deficiency in pediatric patients.

Reviews in endocrine &amp; metabolic disorders
2023

Hypoglycaemia in adrenal insufficiency.

Frontiers in endocrinology
2025

Clinical Characteristics of Children with Combined Pituitary Hormone Deficiency and the Effects of Growth Hormone Treatment.

Klinische Padiatrie
2023

Paraneoplastic isolated adrenocorticotropic hormone deficiency revealed after immune checkpoint inhibitors therapy: new insights into anti-corticotroph antibody.

Frontiers in immunology
2024

Desmopressin Dose Requirements in Adults with Congenital and Acquired Central Diabetes Insipidus.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
2024

Successful pregnancy and delivery in a female with pituitary stalk interruption syndrome following in vitro fertilization and embryo transfer: A case report and literature review.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
2023

Unusual and lesser-known rare causes of adult growth hormone deficiency.

Best practice &amp; research. Clinical endocrinology &amp; metabolism
2023

Mild traumatic brain injury as a cause of adult growth hormone deficiency: Diagnosis and treatment.

Best practice &amp; research. Clinical endocrinology &amp; metabolism
2023

Autoantibodies to selenoprotein P in chronic fatigue syndrome suggest selenium transport impairment and acquired resistance to thyroid hormone.

Redox biology
2023

Acquired Hypothyroidism in Children.

Indian journal of pediatrics
2023

Acquired idiopathic isolated ACTH deficiency with associated autoimmune thyroiditis in pediatrics: case report and review of the literature.

Journal of pediatric endocrinology &amp; metabolism : JPEM
2023

Neuroendocrine Disruptions Following Head Injury.

Current neurology and neuroscience reports
2023

Paraneoplastic autoimmune hypophysitis: a novel form of paraneoplastic endocrine syndrome.

Endocrine journal
2023

Short Stature: Think About the Pituitary Stalk Interruption Syndrome.

Cureus
2023

New developments and concepts in the diagnosis and management of diabetes insipidus (AVP-deficiency and resistance).

Journal of neuroendocrinology
2023

Downregulation of ACAN is Associated with the Growth hormone pathway and Induces short stature.

Journal of clinical laboratory analysis
2022

Analysis of ProP1 Gene in a Cohort of Tunisian Patients with Congenital Combined Pituitary Hormone Deficiency.

Journal of clinical medicine
2022

Pituitary Abscess Causing Hypopituitarism in a Patient With Acquired Immunodeficiency Syndrome.

AACE clinical case reports
2023

Combining metabolomics and machine learning models as a tool to distinguish non-classic 21-hydroxylase deficiency from polycystic ovary syndrome without adrenocorticotropic hormone testing.

Human reproduction (Oxford, England)
2022

Menorrhagia as main presentation sign of severe hypothyroidism in a pediatric patient: a case report.

Italian journal of pediatrics
2022

PEGylated Recombinant Human Growth Hormone Jintrolong® Exhibits Good Long-Term Safety in Cynomolgus Monkeys and Human Pediatric Growth Hormone Deficiency Patients.

Frontiers in endocrinology
2022

Presentation and diagnosis of childhood-onset combined pituitary hormone deficiency: A single center experience from over 30 years.

EClinicalMedicine
2022

Case Report: Acquired Generalized Anhidrosis Caused by Brain Tumor: Review of the Literature.

Frontiers in endocrinology
2022

Adding T2-Weighted Images to FAST1 Protocol to Evaluate the Anatomy of the Hypothalamic-Pituitary Region.

Hormone research in paediatrics
2022

Camurati-Engelmann Disease Complicated by Hypopituitarism: Management Challenges and Literature Review of Outcomes With Bisphosphonates.

AACE clinical case reports
2022

Dental arches in inherited severe isolated growth hormone deficiency.

Growth hormone &amp; IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
2022

Gonadotropin-releasing hormone-secreting neuron development and function: an update.

Minerva endocrinology
2022

Approach to the Pediatric Patient: Central Diabetes Insipidus.

The Journal of clinical endocrinology and metabolism
2022

Is treated hypopituitarism associated with increased left ventricular strains?-detailed analysis from the three-dimensional speckle-tracking echocardiographic MAGYAR-Path Study.

Quantitative imaging in medicine and surgery
2021

Acquired growth hormone deficiency in Fanconi-Bickel syndrome.

BMJ case reports
2022

Fetal and Neonatal Thyroid Dysfunction.

The Journal of clinical endocrinology and metabolism
2021

Short and Long-Term Effects of Growth Hormone in Children and Adolescents With GH Deficiency.

Frontiers in endocrinology
2021

Variability in Oral Desmopressin Dose Requirements in Children with Central Diabetes Insipidus.

The Journal of pediatrics
2021

Advances in differential diagnosis and management of growth hormone deficiency in children.

Nature reviews. Endocrinology
2021

Nuclear Receptor CoRepressors, NCOR1 and SMRT, are required for maintaining systemic metabolic homeostasis.

Molecular metabolism
2021

Design and synthesis of polyacrylic acid/deoxycholic acid-modified chitosan copolymer and a close inspection of human growth hormone-copolymer interactions: An experimental and computational study.

Colloids and surfaces. B, Biointerfaces
2021

Differential Diagnosis of the Short IGF-I-Deficient Child with Apparently Normal Growth Hormone Secretion.

Hormone research in paediatrics
2021

Prevalence of growth hormone deficiency in patients with unexplained chronic fatigue after undergoing bone marrow transplantation in adulthood.

Journal of endocrinological investigation
2021

Aetiologies and clinical patterns of hypopituitarism in Sudanese children.

Sudanese journal of paediatrics
2021

Individuals with isolated congenital GH deficiency due to a GHRH receptor gene mutation appear to cope better with SARS-CoV-2 infection than controls.

Endocrine
2022

Premature Ejaculation and Endocrine Disorders: A Literature Review.

The world journal of men's health
2021

Clinical Heterogeneity of Acquired Idiopathic Isolated Adrenocorticotropic Hormone Deficiency.

Frontiers in endocrinology
2021

Two Cases of anti-PIT-1 Hypophysitis Exhibited as a Form of Paraneoplastic Syndrome not Associated With Thymoma.

Journal of the Endocrine Society
2020

Paediatric hypopituitarism: a case report and management challenges in a resource poor setting.

The Pan African medical journal
2021

The phenotypic spectrum of X-linked, infantile onset ALG13-related developmental and epileptic encephalopathy.

Epilepsia
2020

[Rathke's cleft cyst in a middle-aged man with chief complaint of depression : A case report and literature review].

Zhonghua nan ke xue = National journal of andrology
2020

HPG-Dependent Peri-Pubertal Regulation of Adult Neurogenesis in Mice.

Frontiers in neuroanatomy
2020

Evolving pituitary hormone deficits in primarily isolated GHD: a review and experts' consensus.

Molecular and cellular pediatrics
2021

Clinical lessons learned in constitutional hypopituitarism from two decades of experience in a large international cohort.

Clinical endocrinology
2020

ACQUIRED ECTOPIC POSTERIOR PITUITARY BRIGHT SPOT DUE TO VASCULOTOXIC SNAKEBITE.

AACE clinical case reports
2020

Morphological changes of the cerebral cortex between children with isolated growth hormone deficiency and idiopathic short stature.

Brain research
2020

A case report of glucose transporter 1 deficiency syndrome with growth hormone deficiency diagnosed before starting ketogenic diet.

Italian journal of pediatrics
2020

Acquired forms of central diabetes insipidus: Mechanisms of disease.

Best practice &amp; research. Clinical endocrinology &amp; metabolism
2020

Clinical and Biochemical Characteristics of Severe Hypothyroidism Due to Autoimmune Thyroiditis in Children.

Frontiers in endocrinology
2020

Central hypothyroidism or subclinical hyperthyroidism: can they be confused with each other?

Endocrinology, diabetes &amp; metabolism case reports
2020

Diagnosis and Treatment of Growth Hormone Deficiency: A Position Statement from Korean Endocrine Society and Korean Society of Pediatric Endocrinology.

Endocrinology and metabolism (Seoul, Korea)
2020

How I treat gastrointestinal bleeding in congenital and acquired von Willebrand disease.

Blood
2020

The Optimized Calculation Method for Insulin Dosage in an Insulin Tolerance Test (ITT): A Randomized Parallel Control Study.

Frontiers in endocrinology
2020

Potential applications for rhIGF-I: Bone disease and IGFI.

Growth hormone &amp; IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
2020

Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis.

Nature communications
2020

Geographical influences on the iodine status in pregnant women, neonates, and school-age children in China.

Nutrition journal
2019

A Rare SPRY4 Gene Mutation Is Associated With Anosmia and Adult-Onset Isolated Hypogonadotropic Hypogonadism.

Frontiers in endocrinology
2019

Pathogenesis of Anti-PIT-1 Antibody Syndrome: PIT-1 Presentation by HLA Class I on Anterior Pituitary Cells.

Journal of the Endocrine Society
2020

Autoimmune Pituitary Disease: New Concepts With Clinical Implications.

Endocrine reviews
2019

Systematic profiling of clinical missence mutation effects on the intermolecular interaction between human growth hormone and its receptor in isolated growth hormone deficiency.

Journal of molecular graphics &amp; modelling
2019

Growth hormone treatment and health-related quality of life in children and adolescents: A national, prospective, one-year controlled study.

Clinical endocrinology
2019

Limited Utility of Biochemical Screening for Pituitary Deficiencies and Adverse Effects in Idiopathic GH Deficiency.

Journal of the Endocrine Society
2019

Identification of a Novel PROP1 Mutation in a Patient with Combined Pituitary Hormone Deficiency and Enlarged Pituitary.

International journal of molecular sciences
2019

Androgen potentiates the expression of FSH receptor and supports preantral follicle development in mice.

Journal of ovarian research
2019

Clinical and Immunological Phenotype of Patients With Primary Immunodeficiency Due to Damaging Mutations in NFKB2.

Frontiers in immunology
2019

Pituitary deficiency and precocious puberty after childhood severe traumatic brain injury: a long-term follow-up prospective study.

European journal of endocrinology
2019

Evaluation and management of the child with hypothyroidism.

World journal of pediatrics : WJP
2019

Differences in the functional connectivity density of the brain between individuals with growth hormone deficiency and idiopathic short stature.

Psychoneuroendocrinology
2018

Limited Adherence to Growth Hormone Replacement in Patients with Traumatic Brain Injury.

Journal of rehabilitation medicine. Clinical communications
2018

Less known aspects of central hypothyroidism: Part 1 - Acquired etiologies.

Journal of clinical &amp; translational endocrinology
2018

Basal characteristics and first year responses to human growth hormone (GH) vary according to diagnostic criteria in children with non-acquired GH deficiency (naGHD): observations from a single center over a period of five decades.

Journal of pediatric endocrinology &amp; metabolism : JPEM
2018

Phase 2 Randomized, Placebo-Controlled Clinical Trial of Recombinant Human Growth Hormone (rhGH) During Rehabilitation From Traumatic Brain Injury.

Frontiers in endocrinology
2018

Racial/Ethnic Disparities in US Pediatric Growth Hormone Treatment.

Hormone research in paediatrics
2018

National Program of Severe Growth Hormone Deficiency Treatment in Adults and Adolescents after Completion of Growth Promoting Therapy.

Endokrynologia Polska
2018

Central adrenal insufficiency in children and adolescents.

Best practice &amp; research. Clinical endocrinology &amp; metabolism
2018

IMPORTANCE OF ISOLATED GESTATIONAL HYPOTHYROXINEMIA IN THE DEVELOPMENT OF OBSTETRIC AND SOMATIC PATHOLOGIES.

Georgian medical news
2018

The aryl hydrocarbon receptor is indispensable for dioxin-induced defects in sexually-dimorphic behaviors due to the reduction in fetal steroidogenesis of the pituitary-gonadal axis in rats.

Biochemical pharmacology
2018

Pituitary dysfunction and association with fatigue in stroke and other acute brain injury.

Endocrine connections
2018

Transcriptomics and machine learning predict diagnosis and severity of growth hormone deficiency.

JCI insight
2018

Semen quality in patients with pituitary disease and adult-onset hypogonadotropic hypogonadism.

Endocrine connections
2018

Low FT4 Concentrations around the Start of Recombinant Human Growth Hormone Treatment: Predictor of Congenital Structural Hypothalamic-Pituitary Abnormalities?

Hormone research in paediatrics
2018

Functional Roles of Sex-Biased, Growth Hormone-Regulated MicroRNAs miR-1948 and miR-802 in Young Adult Mouse Liver.

Endocrinology
2018

Iatrogenic Creutzfeldt-Jakob disease with Amyloid-β pathology: an international study.

Acta neuropathologica communications
2018

Hypothalamic abnormalities: Growth failure due to defects of the GHRH receptor.

Growth hormone &amp; IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
2017

Acute development of Cushing syndrome in an HIV-infected child on atazanavir/ritonavir based antiretroviral therapy.

Endocrinology, diabetes &amp; metabolism case reports
2017

Progression from isolated growth hormone deficiency to combined pituitary hormone deficiency.

Growth hormone &amp; IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
2017

Impact of the underlying etiology of growth hormone deficiency on serum IGF-I SDS levels during GH treatment in children.

European journal of endocrinology
2017

Long-Standing Isolated Autoimmune Hypothalamitis Diagnosed with Endoscopic Transventricular Biopsy.

World neurosurgery
2017

Hypopituitarism is associated with lower oxytocin concentrations and reduced empathic ability.

Endocrine
2017

Opioid-induced hyponatremia in a patient with central diabetes insipidus: independence from ADH.

Journal of pediatric endocrinology &amp; metabolism : JPEM
2017

Central hypothyroidism - a neglected thyroid disorder.

Nature reviews. Endocrinology
2017

Stem cell therapy and its potential role in pituitary disorders.

Current opinion in endocrinology, diabetes, and obesity
2017

Growth hormone deficiency and human immunodeficiency virus.

Best practice &amp; research. Clinical endocrinology &amp; metabolism
2017

Classical and non-classical causes of GH deficiency in adults.

Best practice &amp; research. Clinical endocrinology &amp; metabolism
2017

Pattern of Thyroid Disorders in Children and Adolescents Seen at the Lagos University Teaching Hospital, Nigeria, Over a 10-year Period.

Nigerian medical journal : journal of the Nigeria Medical Association
2017

Cholestasis caused by panhypopituitarism and acquired cytomegalovirus infection in a 2-month-old male infant: A case report.

Medicine
2017

A Novel Clinical Entity of Autoimmune Endocrinopathy: Anti-PIT-1 Antibody Syndrome.

Frontiers of hormone research
2017

CENTRAL DIABETES INSIPIDUS: CLINICAL CHARACTERISTICS AND LONG-TERM COURSE IN A LARGE COHORT OF ADULTS.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
2017

A novel thymoma-associated autoimmune disease: Anti-PIT-1 antibody syndrome.

Scientific reports
2016

Untangling the Gordian knot of HIV, stress, and cognitive impairment.

Neurobiology of stress
2017

Baseline Characteristics and Gender Differences in Prepubertal Children Treated with Growth Hormone in Europe, USA, and Japan: 25 Years' KIGS® Experience (1987-2012) and Review.

Hormone research in paediatrics
2017

UK Iatrogenic Creutzfeldt-Jakob disease: investigating human prion transmission across genotypic barriers using human tissue-based and molecular approaches.

Acta neuropathologica
2017

Long-term safety of growth hormone replacement therapy after childhood medulloblastoma and PNET: it is time to set aside old concerns.

Journal of neuro-oncology
2016

Clinical Applications of Gonadotropins in the Male.

Progress in molecular biology and translational science
2016

Hypogonadotropic Hypogonadism and Short Stature in Patients with Diabetes Due to Neurogenin 3 Deficiency.

The Journal of clinical endocrinology and metabolism
2016

Hypopituitarism patterns among adult males with prolactinomas.

Clinical neurology and neurosurgery
2016

The physiology of functional hypothalamic amenorrhea associated with energy deficiency in exercising women and in women with anorexia nervosa.

Hormone molecular biology and clinical investigation
2016

Burden of Growth Hormone Deficiency and Excess in Children.

Progress in molecular biology and translational science
2016

Compensated reduction in Leydig cell function is associated with lower semen quality variables: a study of 8182 European young men.

Human reproduction (Oxford, England)
2016

Reversible growth failure and complete GH deficiency in a 4-year-old girl with very early Hashimoto's thyroiditis and subsequent hyperplasia of pituitary thyrotroph cells.

European journal of pediatrics
2016

Causes of hypogonadotropic hypogonadism predict response to gonadotropin substitution in adults.

Andrology
2015

[Endocrine consequences in young adult survivors of childhood cancer treatment].

Annales d'endocrinologie
2016

Acquired Hypogonadotropic Hypogonadism (AHH) in Thalassaemia Major Patients: An Underdiagnosed Condition?

Mediterranean journal of hematology and infectious diseases
2016

Atypical defects resulting in growth hormone insensitivity.

Growth hormone &amp; IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
2015

Hypotestosteronaemia in the aging male: should we treat it?

Swiss medical weekly
2015

[A Novel Clinical Entity "Anti-PIT-1 Antibody Syndrome"--Autoimmunity against a Transcription Factor].

Rinsho byori. The Japanese journal of clinical pathology
2015

The practical management of testosterone deficiency in men.

Nature reviews. Urology
2015

Autosomal Dominant Growth Hormone Deficiency (Type II).

Pediatric endocrinology reviews : PER
2016

Subjects with isolated GH deficiency due to a null GHRHR mutation eat proportionally more, but healthier than controls.

Endocrine
2015

Age-related testosterone decline is due to waning of both testicular and hypothalamic-pituitary function.

The aging male : the official journal of the International Society for the Study of the Aging Male
2015

Treatment situation of male hypogonadotropic hypogonadism in pediatrics and proposal of testosterone and gonadotropins replacement therapy protocols.

Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology
2015

Anti-PIT-1 antibody syndrome; a novel clinical entity leading to hypopituitarism.

Pediatric endocrinology reviews : PER
2015

Natural history of growth hormone deficiency in a pediatric cohort.

Hormone research in paediatrics
2015

Secondary IGF-I deficiency as a prognostic factor of growth hormone (GH) therapy effectiveness in children with isolated, non-acquired GH deficiency.

Experimental and clinical endocrinology &amp; diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
2015

Reversal of idiopathic hypogonadotropic hypogonadism: a cohort study in Chinese patients.

Asian journal of andrology

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Doenças relacionadas

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Management of infertility in women with hypothalamic hypogonadotropic hypogonadism: an expert opinion.
    Reproductive biology and endocrinology : RB&amp;E· 2026· PMID 41715131mais citado
  2. Acquired transient vasopressin deficiency by cannabinoids and other substances.
    Endocrinology· 2026· PMID 41668460mais citado
  3. GH Response to Glucagon in Transition: Role of BMI and Etiology in Childhood-Onset GH Deficiency.
    The Journal of clinical endocrinology and metabolism· 2026· PMID 41521526mais citado
  4. Hypoprolactinemia: Biology, Clinical Relevance, and Diagnostic Challenges.
    Clinical endocrinology· 2026· PMID 41328476mais citado
  5. Impact of traumatic brain injury severity on anterior pituitary function: A prospective study.
    Clinical neurology and neurosurgery· 2025· PMID 40912111mais citado
  6. Investigation of the Effects of Hypothyroidism Duration on Hearing Function: An Experimental Animal Study.
    Ann Otol Rhinol Laryngol· 2026· PMID 41367191recente
  7. Primary adrenocortical insufficiency in patients with AIDS in Wuhan, China: 3 cases report and literature review.
    BMC Infect Dis· 2025· PMID 41316044recente
  8. First in class monoclonal antibody potentiating human follicle stimulating hormone activity improves spermatogenesis in azoospermic rodent models.
    Front Endocrinol (Lausanne)· 2025· PMID 41163682recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:95502(Orphanet)
  2. MONDO:0019832(MONDO)
  3. GARD:19278(GARD (NIH))
  4. Busca completa no PubMed(PubMed)
  5. Q55788906(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Deficiência de hormônio pituitário adquirida
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Deficiência de hormônio pituitário adquirida

ORPHA:95502 · MONDO:0019832
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C5681569
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