Raras
Buscar doenças, sintomas, genes...
Policitemia secundária
ORPHA:98428CID-10 · D75.1DOENÇA RARA

A policitemia secundária é um excesso de glóbulos vermelhos no sangue. Isso ocorre porque as células que produzem os glóbulos vermelhos, que funcionam normalmente, recebem um estímulo aumentado para fabricá-los em maior quantidade. Essa condição pode ser congênita (desde o nascimento) ou adquirida (desenvolvida ao longo da vida), sendo então chamada de policitemia secundária congênita ou policitemia secundária adquirida.

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Introdução

O que você precisa saber de cara

📋

A policitemia secundária é um excesso de glóbulos vermelhos no sangue. Isso ocorre porque as células que produzem os glóbulos vermelhos, que funcionam normalmente, recebem um estímulo aumentado para fabricá-los em maior quantidade. Essa condição pode ser congênita (desde o nascimento) ou adquirida (desenvolvida ao longo da vida), sendo então chamada de policitemia secundária congênita ou policitemia secundária adquirida.

Pesquisas ativas
2 ensaios
5 total registrados no ClinicalTrials.gov
Publicações científicas
379 artigos
Último publicado: 2026 Apr 1

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
Unknown
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Worldwide
Início
All ages
🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: D75.1
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Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🩸
Sangue
4 sintomas
📏
Crescimento
4 sintomas
🫁
Pulmão
2 sintomas
🧠
Neurológico
2 sintomas
❤️
Coração
2 sintomas
🫘
Rins
1 sintomas

+ 30 sintomas em outras categorias

Características mais comuns

Desidratação
Plétora
Aumento da massa de eritrócitos
Fadiga
Hipotensão
Hipertensão arterial pulmonar
47sintomas
Sem dados (47)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 47 características clínicas mais associadas, ordenadas por frequência.

DesidrataçãoDehydration
PlétoraPlethora
Aumento da massa de eritrócitosIncreased red blood cell mass
FadigaFatigue
HipotensãoHypotension

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico379PubMed
Últimos 10 anos137publicações
Pico202222 papers
Linha do tempo
2026Hoje · 2026🧪 1992Primeiro ensaio clínico📈 2022Ano de pico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

Genes associados

2 genes identificados com associação a esta condição. Padrão de herança: Autosomal dominant, Autosomal recessive.

VHLvon Hippel-Lindau disease tumor suppressorDisease-causing germline mutation(s) inTolerante
FUNÇÃO

Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:10944113, PubMed:17981124, PubMed:19584355). Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions (PubMed:10944113, PubMed:17981124). Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases (PubMed:10944113, PubMed:1

LOCALIZAÇÃO

CytoplasmCell membraneEndoplasmic reticulumNucleus

VIAS BIOLÓGICAS (6)
Antigen processing: Ubiquitination & Proteasome degradationOxygen-dependent proline hydroxylation of Hypoxia-inducible Factor AlphaNeddylationReplication of the SARS-CoV-1 genomeReplication of the SARS-CoV-2 genome
MECANISMO DE DOENÇA

Pheochromocytoma

A catecholamine-producing tumor of chromaffin tissue of the adrenal medulla or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of epinephrine and norepinephrine, is hypertension, which may be persistent or intermittent.

EXPRESSÃO TECIDUAL(Ubíquo)
Linfócitos
47.6 TPM
Fibroblastos
30.1 TPM
Cérebro - Hemisfério cerebelar
29.8 TPM
Baço
24.1 TPM
Cervix Endocervix
22.7 TPM
OUTRAS DOENÇAS (6)
pheochromocytomavon Hippel-Lindau diseasenonpapillary renal cell carcinomaChuvash polycythemia
HGNC:12687UniProt:P40337
BPGMBisphosphoglycerate mutaseCandidate gene tested inTolerante
FUNÇÃO

Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.11) activity

LOCALIZAÇÃO

VIAS BIOLÓGICAS (1)
Glycolysis
MECANISMO DE DOENÇA

Erythrocytosis, familial, 8

An autosomal recessive disorder characterized by elevated serum hemoglobin and hematocrit, and biphosphoglycerate mutase deficiency. ECYT8 affected individuals manifest hemolytic anemia and splenomegaly.

VIAS REACTOME (1)
OUTRAS DOENÇAS (2)
hemolytic anemia due to diphosphoglycerate mutase deficiencyautosomal recessive secondary polycythemia not associated with VHL gene
HGNC:1093UniProt:P07738

Variantes genéticas (ClinVar)

790 variantes patogênicas registradas no ClinVar.

🧬 BPGM: GRCh37/hg19 7q31.32-36.1(chr7:122190535-149944340)x1 ()
🧬 BPGM: GRCh37/hg19 7q31.31-33(chr7:120582003-137699953)x1 ()
🧬 BPGM: NM_001724.5(BPGM):c.679C>T (p.Arg227Cys) ()
🧬 BPGM: NC_000007.13:g.(?_130781014)_(150301047_?)del ()
🧬 BPGM: GRCh37/hg19 7q32.3-36.1(chr7:131779213-149042734)x1 ()
Ver todas no ClinVar

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

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Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
·Pré-clínico4
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 4 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Policitemia secundária

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

🟢 Recrutando agora

1 pesquisa recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

Outros ensaios clínicos

5 ensaios clínicos encontrados, 2 ativos.

Distribuição por fase
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
139 papers (10 anos)
#1

Simple virilizing form of 21-hydroxylase deficiency presenting with renal Insufficiency and polycythemia: a case report.

Frontiers in endocrinology2026

The simple virilizing (SV) form of 21-hydroxylase deficiency (21-OHD) is primarily characterized by androgen excess. Gonadal dysfunction is widely acknowledged; however, systemic complications, including renal injury, are often overlooked. This report presents a rare case involving a 25-year-old female diagnosed with SV 21-OHD, who subsequently experienced unanticipated renal insufficiency and secondary polycythemia. Genetic analysis confirmed compound heterozygous mutations in the CYP21A2 gene. The patient demonstrated significant hyperandrogenemia and polycythemia driven by erythropoietin. Following erythrocytapheresis and glucocorticoid replacement therapy, androgen levels normalized, resulting in marked renal function recovery and resolution of polycythemia. This case and a mechanistic review illustrate the potential interplay between chronic hyperandrogenism, erythropoiesis dysregulation, and kidney injury, underscoring the importance of timely hormonal management for the preservation of long-term renal function in CAH (Congenital adrenal hyperplasia).

#2

Anabolic Androgen Abuse-Associated Cerebral Venous Sinus Thrombosis in a Young Adult: A Case Report.

Cureus2026 Jan

Cerebral venous sinus thrombosis (CVST) is a rare and potentially life-threatening cause of stroke that predominantly affects young adults and often presents with nonspecific symptoms, leading to diagnostic delay. We report the case of a 29-year-old man with no prior medical comorbidities who presented with a progressively worsening headache and new-onset generalized tonic-clonic seizure. Detailed history revealed long-term abuse of anabolic androgenic steroids for bodybuilding purposes. Clinical examination demonstrated papilledema, and laboratory investigations were notable for secondary polycythemia, while an extensive thrombophilia workup was unremarkable. Neuroimaging with computed tomography and magnetic resonance venography confirmed thrombosis of the superior sagittal and right transverse sinuses with associated venous infarction. The patient was managed with therapeutic anticoagulation, antiepileptic therapy, and measures to control intracranial pressure, alongside immediate cessation of androgen use. His clinical course was favorable, with symptomatic improvement, partial radiological recanalization, and complete neurological recovery at follow-up. This case highlights androgen abuse as a rare but important reversible risk factor for CVST and underscores the importance of thorough substance use history taking, early diagnosis, and prompt anticoagulation to optimize outcomes.

#3

Evaluating inflammatory markers in distinguishing polycythemia Vera from secondary polycythemia: a prospect for novel diagnostic marker.

Annals of hematology2026 Jan 15

Polycythemia vera (PV) is a myeloproliferative neoplasm. The presence of JAK2 mutations is a major diagnostic criterion for PV. PV is linked to chronic inflammation and an increased risk of thrombosis, and inflammation plays a significant part in the pathophysiology of PV. Testing for JAK2 mutations is expensive and is not available in all laboratories. Simple inflammatory markers, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII), are evaluated in this study as potential diagnostic markers for differentiating patients with PV from other patients with polycythemia. We conducted a retrospective study of the clinical and laboratory data from 281 patients with polycythemia (110 with PV and 181 with secondary polycythemia (SP)) who attended Ghaem Hospital. The diagnosis of PV was established based on the World Health Organization criteria. Individuals who did not meet the criteria were classified as having SP. The median NLR, PLR, and SII in the PV group were considerably elevated compared to the SP group (NLR: 5.00 vs. 1.86, PLR: 261.3 vs. 94.0, SII: 2432.9 vs. 368.8, p < 0.001 for all). The receiver operating characteristic analysis revealed that NLR, PLR, and SII were highly effective in differentiating PV patients from the SP group. Each of these tests showed sensitivities and specificities over 85% and an area under the curve of more than 0.9. SII, NLR, and PLR were all higher in PV than SP, suggesting that these biomarkers, particularly SII, might be helpful in the diagnosis of PV.

#4

Iatrogenic Post-Surgical Cyanosis Due to Vena Caval Redirection to the Left Atrium and Its Transcatheter Management.

Pediatric cardiology2026 Jan

During surgery for oval fossa defects, inadvertent suturing of pericardial patches to a prominent Eustachian valve diverts the inferior vena caval blood to the left atrium causing iatrogenic cyanosis. A similar complication may arise after surgery for superior sinus venosus defects. Surgical patch in a wrong plane may direct the superior vena cava towards the left atrium. Early post-operative diagnosis leads to immediate correction. Diagnosis delayed beyond many years lead to chronic hypoxemia and secondary polycythemia. This report details the clinical presentation and imaging of this iatrogenic complication in three patients and explains a transcatheter corrective intervention.

#5

The Utility of Serum Free Testosterone Concentrations in Monitoring Gender-Affirming Testosterone Therapy in Transmasculine Youth with Obesity.

Transgender health2025 Oct

This study aimed to explore the use of serum free testosterone concentrations in transmasculine patients as a more reliable indicator of gender-affirming testosterone therapy than total testosterone concentration. Total testosterone values, recommended by current guidelines, may be impacted by obesity. In addition, this study aimed to characterize the impact of testosterone concentrations on hematocrit and the risk of polycythemia. A retrospective study was conducted of transmasculine patients seen at Boston Children's Hospital Gender Multispecialty Service from 2007 to 2020. Sixty-eight birth-assigned female adolescents who were receiving gender-affirming testosterone therapy and had total and free testosterone concentrations were included. The aims were to determine the fidelity of total and free testosterone concentrations with body mass index (BMI) and to characterize the association of testosterone concentrations with erythrocytosis. Of 68 subjects, 23% were overweight and 40% had obesity. Compared with the group with a healthy BMI, patients with obesity had significantly lower total testosterone concentrations. Free testosterone concentrations did not vary based on BMI category. BMI z-score was inversely correlated with total testosterone, sex hormone-binding globulin, and albumin concentrations but not with free testosterone concentrations. Four percent of subjects developed erythrocytosis (e.g., hematocrit >50%). Neither BMI nor testosterone concentrations were correlated with hematocrit. Free testosterone concentrations are an adjunctive tool in the monitoring of gender-affirming testosterone therapy. In addition, the development of erythrocytosis is independent of serum testosterone concentration and warrants further study to understand factors that may predispose patients to developing secondary polycythemia.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC151 artigos no totalmostrando 136

2026

Simple virilizing form of 21-hydroxylase deficiency presenting with renal Insufficiency and polycythemia: a case report.

Frontiers in endocrinology
2026

Anabolic Androgen Abuse-Associated Cerebral Venous Sinus Thrombosis in a Young Adult: A Case Report.

Cureus
2026

Evaluating inflammatory markers in distinguishing polycythemia Vera from secondary polycythemia: a prospect for novel diagnostic marker.

Annals of hematology
2025

The Utility of Serum Free Testosterone Concentrations in Monitoring Gender-Affirming Testosterone Therapy in Transmasculine Youth with Obesity.

Transgender health
2025

Low neutrophil-to-lymphocyte ratio identifies secondary polycythemia in patients with erythrocytosis.

Scientific reports
2025

Prevalence of Obstructive Sleep Apnea Among Patients with Secondary Polycythemia: A Retrospective Cross-sectional Study.

Oman medical journal
2025

Hemoglobin as a Treatable Trait in COPD: A Retrospective Observational Cohort Study on Hemoglobin Levels and All-Cause Mortality from NHANES Data.

International journal of chronic obstructive pulmonary disease
2025

Polycythemia secondary to renal dromedary hump in a young healthy woman: a case report.

Journal of medical case reports
2025

Metabolomic Profiling Reveals Distinct Signatures in Primary and Secondary Polycythemia.

Metabolites
2025

Characterization of primary and secondary polycythemia among Palestinian blood donors in the West bank.

Scientific reports
2025

Cerebral Venous Sinus Thrombosis: A Complication of Secondary Polycythemia From Testosterone Use.

Cureus
2025

Surviving Unrepaired Tetralogy of Fallot to 43 Years in a Low-Resource Setting: The Oldest Reported Case from Somalia.

International medical case reports journal
2025

Erythrocytosis as an indicator of disease progression of small cell lung cancer: A case report.

Respiratory medicine case reports
2025

Effect of Altitude on Polycythemia Vera: Is it Necessary to Change Limits?

High altitude medicine &amp; biology
2025

Impact of Hematocrit on Coagulation Measured by Rotational Thromboelastometry in Healthy Subjects and Patients with Polycythemia.

Seminars in thrombosis and hemostasis
2025

Combined storage and intraoperative autologous blood transfusion with thrombosis prevention for secondary polycythemia induced by a giant broad ligament leiomyoma: A case report.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
2025

Polycythemia secondary to bilaterally enlarged kidneys in T-Cell acute lymphoblastic leukemia: a case report and literature review.

BMC nephrology
2025

Multi-omics analysis reveals the molecular mechanisms and therapeutic targets in high altitude polycythemia.

Annales de biologie clinique
2026

Iatrogenic Post-Surgical Cyanosis Due to Vena Caval Redirection to the Left Atrium and Its Transcatheter Management.

Pediatric cardiology
2024

Prevalence and Risk Factors of Pulmonary Embolism in COPD Patients Complicated with Secondary Polycythemia.

International journal of chronic obstructive pulmonary disease
2024

Polycythemia Vera With High Serum Erythropoietin Level: A Case Report and Literature Review.

Cureus
2024

Acute Ischemic Stroke as a Manifestation of Secondary Polycythemia in a Patient of Adult Complex Cyanotic Congenital Heart Disease: A Case Report.

The Journal of the Association of Physicians of India
2024

Management of Fallot's Uncorrected Tetralogy in Adulthood: A Narrative Review.

Cureus
2024

Non-ischemia Cardiomyopathy and Polycythemia Secondary to Anabolic-Androgenic Steroid Use.

Cureus
2024

Polycythemia Prevalence and Risk Factors in Pilots.

Aerospace medicine and human performance
2024

Secondary Polycythemia May Be an Early Clinical Manifestation of Multiple Myeloma: A Case Report.

Journal of blood medicine
2024

Diffuse pulmonary arteriovenous malformation presenting with secondary polycythemia and headaches: a case report.

Journal of medical case reports
2024

The Systemic Inflammation Index: A New Candidate Minor Criterion in the Diagnosis of Polycythemia Vera.

Journal of personalized medicine
2024

A rare case of venous sinus thrombosis and pulmonary embolisms secondary to myomatous erythrocytosis syndrome.

AJOG global reports
2024

Hemangioblastoma: An Uncommon Cause of Polycythemia in a Child.

Journal of Nepal Health Research Council
2024

Secondary Polycythemia and Non-Islet Cell Tumor-induced Hypoglycemia in Advanced Hepatocellular Carcinoma: A Case Report.

Acta medica Indonesiana
2024

Updated threshold, renewed problems: should the diagnostic criteria of polycythemia vera be reconsidered? A retrospective cross-sectional cohort study.

Revista da Associacao Medica Brasileira (1992)
2024

Secondary polycythemia in acutely ill COVID-19 patients is associated with higher mortality but not markedly higher thrombotic risk.

Scandinavian journal of clinical and laboratory investigation
2024

Obstructive Sleep Apnea Does Not Exclude Polycythemia Vera: A Case Report.

Case reports in oncology
2023

Concomitant Cerebral Venous Thrombosis and Intracranial Hemorrhages in Presentation of a Patient with Secondary Polycythemia: A Case Report.

The American journal of case reports
2023

Distinct non-contrast computerized tomography head findings in a patient with secondary polycythemia in rural Nepal: a captivating case report highlighting diagnostic challenges.

Annals of medicine and surgery (2012)
2023

Chronic Kidney Disease has a Higher Prevalence in Polycythemia Vera than in Secondary Polycythemia, a Matched Case-Control Analysis.

Indian journal of hematology &amp; blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion
2023

[Erythrocytosis after hematopoietic stem cell transplantation: report of 3 cases and literature review].

Zhonghua nei ke za zhi
2023

Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as new possible minor criteria for diagnosis of polycythemia vera.

International journal of laboratory hematology
2023

Secondary polycythaemia from chronic hypoxia is a risk for cerebral thrombosis: a case report.

BMC neurology
2023

Polycythemia among Patients with Chronic Obstructive Pulmonary Disease Admitted to the Department of Medicine in a Tertiary Care Center: A Descriptive Cross-sectional Study.

JNMA; journal of the Nepal Medical Association
2024

Polycythemia Secondary to Renal Hemangioblastoma: A Case Report and Literature Review.

International journal of surgical pathology
2023

Prevalence and diagnostic performance of iron deficiency in polycythemia.

Hematology (Amsterdam, Netherlands)
2023

Chronic Obstructive Pulmonary Disease and Its Effect on Red Blood Cell Indices.

Cureus
2023

Myomatous erythrocytosis syndrome-an uncommon cause of secondary polycythemia.

Annals of hematology
2023

Secondary erythrocytosis.

Expert review of hematology
2023

Polycythemia with elevated erythropoietin production in a patient with a urinary stone and unilateral hydronephrosis: a case report.

Journal of medical case reports
2023

Idiopathic Membranous Glomerulonephritis Leading to Secondary Polycythemia: A Rare Association.

Cureus
2023

Acute limb ischaemia in a young male with secondary polycythaemia: A case report.

Radiology case reports
2022

[A case of recurrent cerebral infarction in an adult patient with false Taussig-Bing anomaly].

Rinsho shinkeigaku = Clinical neurology
2022

Diagnosis and genetic analysis of polycythemia in children and a novel EPAS1 gene mutation.

Pediatrics and neonatology
2022

Analysis of JAK2V617F Tyrosine Kinase Mutation in Blood Donors with Erythrocytosis - A Pilot Study in a Tertiary Care Teaching Hospital of South India.

Journal of blood medicine
2022

A thrombotic event in a HeartMate 3 patient in the setting of secondary polycythemia.

Proceedings (Baylor University. Medical Center)
2022

Prevalence of elevated hemoglobin and hematocrit levels in patients with obstructive sleep apnea and the impact of treatment with continuous positive airway pressure: a meta-analysis.

Hematology (Amsterdam, Netherlands)
2023

Incidence, Contributing Factors, and Implications for Clinical Management of Polycythemia in Transmasculine Patients on Testosterone.

LGBT health
2023

Revisiting the impact of serial therapeutic phlebotomy in polycythaemia on laboratory and clinical parameters using a fixed interval and fixed volume protocol.

Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine
2022

Breaking Stereotypes: Polycythemia Secondary to Shisha Smoking in a Middle-Age Swiss Woman.

Acta haematologica
2022

Polycythemia-Related Proliferative Ischemic Retinopathy Managed with Smoking Cessation: A Case Report.

International journal of environmental research and public health
2022

A case of congenital methaemoglobinaemia with secondary polycythemia.

JPMA. The Journal of the Pakistan Medical Association
2022

Polycythemia in dogs with chronic hypoxic pulmonary disease.

Journal of veterinary internal medicine
2022

Secondary Polycythemia in Men Receiving Testosterone Therapy Increases Risk of Major Adverse Cardiovascular Events and Venous Thromboembolism in the First Year of Therapy. Letter.

The Journal of urology
2022

Secondary Polycythemia in Men Receiving Testosterone Therapy Increases Risk of Major Adverse Cardiovascular Events and Venous Thromboembolism in the First Year of Therapy. Reply.

The Journal of urology
2022

Endovascular Embolisation of Pulmonary Arteriovenous Malformation Using Amplatzer Vascular Plugs.

Cureus
2022

High platelet-to-lymphocyte ratio may differentiate polycythemia vera from secondary polycythemia.

Wiener klinische Wochenschrift
2022

Unintentional Dual Benefit: Improvement in Secondary Polycythemia in a Patient Receiving Chemotherapy for Metastatic Clear Cell Renal Cell Carcinoma.

European journal of case reports in internal medicine
2022

CLINICAL CASE OF GAISBÖCK SYNDROME CAUSED BY HOOKAH AND TOBACCO SMOKING: "ZEBRA" OR "HORSE"?

Wiadomosci lekarskie (Warsaw, Poland : 1960)
2022

Secondary Polycythemia in Men Receiving Testosterone Therapy Increases Risk of Major Adverse Cardiovascular Events and Venous Thromboembolism in the First Year of Therapy.

The Journal of urology
2022

Polycythemia secondary to renal cysts.

Journal of nephrology
2022

Testosterone therapy and secondary erythrocytosis.

International journal of impotence research
2021

Tobacco Smoking and Liver Cancer Risk: Potential Avenues for Carcinogenesis.

Journal of oncology
2022

Thrombotic risk in secondary polycythemia resembles low-risk polycythemia vera and increases in specific subsets of patients.

Thrombosis research
2022

Clinical and Radiological Profile of Cerebrovascular Disease in Polycythemia: Analysis of Neurologic Manifestations from a Tertiary Center in South India.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
2022

Hematocrit to hemoglobin ratio as a prognostic marker in polycythemia vera.

Wiener klinische Wochenschrift
2021

Polycythemia in a Patient With Atonic Bladder and Hydronephrosis.

Cureus
2021

Management of Free-Floating Thrombus in the Vertebral Artery in a Middle-Aged Smoker with Secondary Polycythemia Vera.

International medical case reports journal
2021

Yippee like 4 (Ypel4) is essential for normal mouse red blood cell membrane integrity.

Scientific reports
2021

Secondary polycythemia in chronic obstructive pulmonary disease: prevalence and risk factors.

BMC pulmonary medicine
2021

Successful use of phlebotomy to treat severe secondary polycythemia due to chronic lung disease.

Hematology reports
2021

Polycythemia is Associated with Lower Incidence of Severe COPD Exacerbations in the SPIROMICS Study.

Chronic obstructive pulmonary diseases (Miami, Fla.)
2021

Evaluation of beta-2 microglobulin, erythropoietin and tobacco use in polycythemic cases.

International journal of hematology
2021

Bone Marrow and Peripheral Blood Findings in Patients Infected by SARS-CoV-2.

American journal of clinical pathology
2021

Diagnostic Performance of Erythropoietin Levels in Polycythemia Vera: Experience at a Comprehensive Cancer Center.

Clinical lymphoma, myeloma &amp; leukemia
2020

Acute normovolemic hemodilution for a patient with secondary polycythemia undergoing aortic valve replacement due to severe aortic stenosis - A case report.

Anesthesia and pain medicine
2021

Might a high hemoglobin mass be involved in non-cardiogenic pulmonary edema? The case of the chronic maladaptation to high-altitude in the Andes.

Medical hypotheses
2021

Generalized Chorea Due to Secondary Polycythemia Responding to Phlebotomy.

Journal of movement disorders
2020

Hepatocellular Carcinoma With Extensive Cancer-associated Thrombosis Successfully Treated With Liver Resection and Direct Oral Anticoagulant: A Case Report.

Anticancer research
2021

Higher red blood cell distribution width might differentiate primary from secondary polycythemia: A pilot study.

International journal of laboratory hematology
2021

Pazopanib-related secondary polycythemia in metastatic myxofibrosarcoma: A case report and review of the literature.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners
2021

A cross-sectional comparison of secondary polycythemia in testosterone-deficient men treated with nasal testosterone gel vs. intramuscular testosterone cypionate.

Canadian Urological Association journal = Journal de l'Association des urologues du Canada
2020

General Anesthesia During Lip Repair and Palatoplasty After Glenn Surgery.

Anesthesia progress
2021

Erythropoietin-producing clear cell renal cell carcinoma associated with secondary polycythemia.

Hematology, transfusion and cell therapy
2020

Polycythaemia Vera JAK 2 Mutation in a Patient with Underlying Chronic Obstructive Pulmonary Disease at a Primary Care Setting.

Korean journal of family medicine
2020

Differential cytokine network profile in polycythemia vera and secondary polycythemia.

Scientific reports
2020

Obstructive Sleep Apnea Is Associated With Polycythemia in Hypogonadal Men on Testosterone Replacement Therapy.

The journal of sexual medicine
2020

Venous thromboembolism associated with hyperhomocysteinemia, homozygosity for the methylenetetrahydrofolate reductase 677C>T gene variant, and secondary polycythemia.

Blood coagulation &amp; fibrinolysis : an international journal in haemostasis and thrombosis
2020

Tobacco smoking causes secondary polycythemia and a mild leukocytosis among heavy smokers in Taif City in Saudi Arabia.

Saudi journal of biological sciences
2019

Nocturnal Mean Oxygen Saturation Is Associated with Secondary Polycythemia in Young Adults with Obstructive Sleep Apnea, Especially in Men.

Nature and science of sleep
2019

Management of macular edema with branch retinal vein occlusion in a case of secondary polycythemia.

GMS ophthalmology cases
2019

An unusual case of pulmonary arterio-venous fistula (PAVF).

Journal of family medicine and primary care
2019

Clinical Spectrum and Complications of Polycythemia, in Patients presenting at Tertiary Care Centre at Goa.

The Journal of the Association of Physicians of India
2022

UNUSUAL CAUSE OF BRANCH RETINAL ARTERY OCCLUSION: POLYCYTHEMIA IN A TRANSGENDER MAN FROM UNREGULATED TESTOSTERONE USE.

Retinal cases &amp; brief reports
2020

Increased Pulmonary GM-CSF Causes Alveolar Macrophage Accumulation. Mechanistic Implications for Desquamative Interstitial Pneumonitis.

American journal of respiratory cell and molecular biology
2019

Anisocytosis is a poor prognostic factor in secondary polycythemia.

Leukemia &amp; lymphoma
2019

Polycythemia in Patients With Hereditary Hemochromatosis: Real or Myth?

Journal of clinical medicine research
2019

Treating Myomatous Erythrocytosis Syndrome With Uterine Artery Embolization.

Obstetrics and gynecology
2019

Clomiphene for hypogonadism complicated by polycythemia.

Proceedings (Baylor University. Medical Center)
2019

Testosterone replacement therapy is associated with an increased risk of urolithiasis.

World journal of urology
2019

Secondary polycythemia in a sarcoma patient: a commentary about cediranib.

Current oncology (Toronto, Ont.)
2019

The role of 18F-FDG PET in the assessment of a benign hematological disorder: polycythemia.

Hellenic journal of nuclear medicine
2019

Hepatopulmonary syndrome-attributed extreme hypoxemia and polycythemia revealing liver cirrhosis.

The American journal of emergency medicine
2018

[Detection and Diagnostic Values of JAK2, CALR, MPL Gene Mutations in 208 Cases of BCR/ABL1 Negative Chronic Myeloproliferative Diseases].

Zhongguo shi yan xue ye xue za zhi
2018

Ischemic Stroke Caused by Secondary Polycythemia and Incidentally-Found Renal Cell Carcinoma: A Case Report.

The American journal of case reports
2018

[A case of severe obstructive sleep apnea hypopnea syndrome with urinary and anal incontinence].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
2018

Relationships of Serum Iron Parameters and Hemoglobin with Forced Expiratory Volume in 1 Second in Patients with Chronic Obstructive Pulmonary Disease.

Korean journal of family medicine
2018

A novel splicing site IRP1 somatic mutation in a patient with pheochromocytoma and JAK2V617F positive polycythemia vera: a case report.

BMC cancer
2018

Severe Secondary Polycythemia in a Female-to-Male Transgender Patient While Using Lifelong Hormonal Therapy: A Patient's Perspective.

Drug safety - case reports
2018

Which patients with moderate hypoxemia benefit from long-term oxygen therapy? Ways forward.

International journal of chronic obstructive pulmonary disease
2017

Does untreated obstructive sleep apnea cause secondary erythrocytosis?

Respiratory medicine
2018

Association of subcutaneous testosterone pellet therapy with developing secondary polycythemia.

Asian journal of andrology
2017

Case: Secondary polycythemia due to pazopanib in patients with metastatic renal cell carcinoma.

Canadian Urological Association journal = Journal de l'Association des urologues du Canada
2017

Right Hand Weakness and Headache During Ascent to Mount Everest: A Case of Cerebral Venous Infarction.

The neurologist
2017

Cerebral Abscess Associated With Odontogenic Bacteremias, Hypoxemia, and Iron Loading in Immunocompetent Patients With Right-to-Left Shunting Through Pulmonary Arteriovenous Malformations.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2017

Hemoglobin Wayne Trait with Incidental Polycythemia.

Annals of clinical and laboratory science
2017

Novel hematological parameters for the evaluation of patients with myeloproliferative neoplasms: the immature platelet and reticulocyte fractions.

Annals of hematology
2016

Relationship between polycythemia and in-hospital mortality in chronic obstructive pulmonary disease patients with low-risk pulmonary embolism.

Journal of thoracic disease
2016

Hemiretinal Artery Occlusion in an 11-Year-Old Child with Dextrocardia.

Case reports in ophthalmological medicine
2017

Cerebral venous thrombosis at high altitude: A systematic review.

Revue neurologique
2017

A Comparison of Secondary Polycythemia in Hypogonadal Men Treated with Clomiphene Citrate versus Testosterone Replacement: A Multi-Institutional Study.

The Journal of urology
2016

Quantification of IGF-1 Receptor May Be Useful in Diagnosing Polycythemia Vera-Suggestion to Be Added to Be One of the Minor Criterion.

PloS one
2017

A novel biological function of soluble biglycan: Induction of erythropoietin production and polycythemia.

Glycoconjugate journal
2016

Cerebral venous thrombosis and secondary polycythemia in a case of nephrotic syndrome.

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia
2016

[Inherited primitive and secondary polycythemia].

La Revue de medecine interne
2015

Bilateral renal T-cell lymphoma with hepatic infiltration and secondary polycythemia in a dog: Utility of cytology slides.

The Canadian veterinary journal = La revue veterinaire canadienne
2015

Symptomatic Secondary Polycythemia Induced by Anti-VEGF Therapy for the Treatment of Metastatic Renal Cell Carcinoma: A Case Series and Review.

Clinical genitourinary cancer
2015

Matrix Metalloproteinases 2 and 9 Polymorphism in Patients With Myeloproliferative Diseases: A STROBE-Compliant Observational Study.

Medicine
2015

Pulmonary embolism in a patient of tetralogy of Fallot: a diagnostic challenge.

The American journal of emergency medicine
Ver todos os 151 no EuropePMC

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Doenças relacionadas

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Simple virilizing form of 21-hydroxylase deficiency presenting with renal Insufficiency and polycythemia: a case report.
    Frontiers in endocrinology· 2026· PMID 41788783mais citado
  2. Anabolic Androgen Abuse-Associated Cerebral Venous Sinus Thrombosis in a Young Adult: A Case Report.
    Cureus· 2026· PMID 41742990mais citado
  3. Evaluating inflammatory markers in distinguishing polycythemia Vera from secondary polycythemia: a prospect for novel diagnostic marker.
    Annals of hematology· 2026· PMID 41535608mais citado
  4. Iatrogenic Post-Surgical Cyanosis Due to Vena Caval Redirection to the Left Atrium and Its Transcatheter Management.
    Pediatric cardiology· 2026· PMID 39672937mais citado
  5. The Utility of Serum Free Testosterone Concentrations in Monitoring Gender-Affirming Testosterone Therapy in Transmasculine Youth with Obesity.
    Transgender health· 2025· PMID 41340815mais citado
  6. Analysis of Blood Group Antigens as Risk Factors for Thrombosis in Polycythemia Vera Patients.
    Clin Lab· 2026· PMID 41979638recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:98428(Orphanet)
  2. MONDO:0020115(MONDO)
  3. GARD:19467(GARD (NIH))
  4. Variantes catalogadas(ClinVar)
  5. Busca completa no PubMed(PubMed)
  6. Q18555212(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Policitemia secundária
Compêndio · Raras BR

Policitemia secundária

ORPHA:98428 · MONDO:0020115
Prevalência
Unknown
Herança
Autosomal dominant, Autosomal recessive
CID-10
D75.1 · Policitemia secundária
Ensaios
2 ativos
Início
All ages
Prevalência
0.0 (Worldwide)
MedGen
UMLS
C1318533
EuropePMC
Wikidata
Papers 10a
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