A Poroceratose Actínica Superficial Disseminada (PASD) é o tipo mais comum de poroceratose (um problema de pele). Ela se caracteriza pelo aparecimento de várias pequenas manchas ou lesões em forma de anel, com uma borda em relevo, mais grossa e áspera. Essas lesões surgem com mais frequência nas áreas da pele expostas ao sol, especialmente nos braços e pernas (as extremidades).
Introdução
O que você precisa saber de cara
A Poroceratose Actínica Superficial Disseminada (PASD) é o tipo mais comum de poroceratose (um problema de pele). Ela se caracteriza pelo aparecimento de várias pequenas manchas ou lesões em forma de anel, com uma borda em relevo, mais grossa e áspera. Essas lesões surgem com mais frequência nas áreas da pele expostas ao sol, especialmente nos braços e pernas (as extremidades).
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 3 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 7 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
4 genes identificados com associação a esta condição. Padrão de herança: Autosomal dominant.
Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product fa
Cytoplasm
Porokeratosis 9, multiple types
A form of porokeratosis, a disorder of faulty keratinization characterized by one or more atrophic patches surrounded by a distinctive hyperkeratotic ridgelike border called the cornoid lamella. The keratotic lesions can progress to overt cutaneous neoplasms, typically squamous cell carcinomas. Multiple clinical variants of porokeratosis are recognized, including porokeratosis of Mibelli, linear porokeratosis, disseminated superficial actinic porokeratosis, palmoplantar porokeratosis, and punctate porokeratosis. Different clinical presentations can be observed among members of the same family. Individuals expressing more than one variant have also been reported.
Voltage-gated ATP nucleotide uniporter that can also transport the purine nucleotides ADP and GTP. Uses the membrane potential as the driving force to control ATP accumulation in lysosomes and secretory vesicles (PubMed:18375752, PubMed:23467297). By controlling ATP storage in lysosomes, regulates ATP-dependent proteins of these organelles (PubMed:35269509). Also indirectly regulates the exocytosis of ATP through its import into lysosomes in astrocytes and secretory vesicles such as adrenal chro
Cytoplasmic vesicle, secretory vesicle, chromaffin granule membraneCytoplasmic vesicle, secretory vesicle membraneLysosome membrane
Porokeratosis 8, disseminated superficial actinic type
A form of porokeratosis, a disorder of faulty keratinization characterized by one or more atrophic patches surrounded by a distinctive hyperkeratotic ridgelike border called the cornoid lamella. The keratotic lesions can progress to overt cutaneous neoplasms, typically squamous cell carcinomas. Multiple clinical variants of porokeratosis are recognized, including porokeratosis of Mibelli, linear porokeratosis, disseminated superficial actinic porokeratosis, palmoplantar porokeratosis, and punctate porokeratosis. Disseminated superficial actinic porokeratosis (DSAP) is the most common subtype. It is characterized by multiple small, annular, anhidrotic, keratotic lesions that are located predominantly on sun-exposed areas of the skin, such as the face, neck, and distal limbs. The lesions typically begin to develop in adolescence and reach near-complete penetrance by the third or fourth decade of life.
Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis (PubMed:11278915, PubMed:18302342, PubMed:9325256, PubMed:9392419)
CytoplasmPeroxisome
Mevalonic aciduria
Accumulation of mevalonic acid which causes a variety of symptoms such as psychomotor retardation, dysmorphic features, cataracts, hepatosplenomegaly, lymphadenopathy, anemia, hypotonia, myopathy, and ataxia.
Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis
Cytoplasm
Porokeratosis 7, multiple types
A form of porokeratosis, a disorder of faulty keratinization characterized by one or more atrophic patches surrounded by a distinctive hyperkeratotic ridgelike border called the cornoid lamella. The keratotic lesions can progress to overt cutaneous neoplasms, typically squamous cell carcinomas. Multiple clinical variants of porokeratosis are recognized, including porokeratosis of Mibelli, linear porokeratosis, disseminated superficial actinic porokeratosis, palmoplantar porokeratosis, and punctate porokeratosis. Different clinical presentations can be observed among members of the same family. Individuals expressing more than one variant have also been reported.
Variantes genéticas (ClinVar)
309 variantes patogênicas registradas no ClinVar.
Classificação de variantes (ClinVar)
Distribuição de 1 variantes classificadas pelo ClinVar.
Vias biológicas (Reactome)
3 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Poroqueratose actínica disseminada superficial
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Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
Pesquisa e ensaios clínicos
0 ensaios clínicos encontrados.
Publicações mais relevantes
Identification of two novel MVD mutations and one novel FDPS mutation in Chinese patients with porokeratosis.
Porokeratosis (PK) is an autosomal dominant inherited disorder characterized by abnormal epidermal keratinization, primarily resulting from mutations in four genes associated with the mevalonate pathway: mevalonate decarboxylase (MVD), mevalonate kinase (MVK), phosphomevalonate kinase (PMVK), and farnesyl diphosphate synthase (FDPS). The purpose of this study was to identify the causative mutations in seven sporadic cases of PK. Clinical data and blood samples were collected from these seven sporadic cases. To identify pathogenic gene mutations in the patients, both whole-exome and Sanger sequencing were conducted. Bioinformatics resources such as PROVEAN, SIFT, PolyPhen-2, and Mutation Taster were employed to assess the pathogenicity of the identified mutations. This study included seven sporadic cases of PK, comprising two cases of disseminated superficial actinic porokeratosis (DSAP), and five cases of disseminated superficial porokeratosis (DSP). We identified a total of five heterozygous mutations, including two novel MVD mutations (c.1122 + 1G > A, c.576G > T), one novel FDPS mutation (c.986A > C), and two MVD mutations that have been reported previously (c.1A > G and c.746 T > C). In conjunction with our previous study, we identified a total of six patients with the MVD c.746 T > C mutation from Jiangxi province, China, representing 50% of the total MVD mutation cases (12 in total). This research has expanded the database of mevalonate pathway genes associated with PK, thereby improving our comprehension of the fundamental mechanisms involved.
Disseminated Superficial Actinic Porokeratosis in a Woman With Metastatic Pancreatic Cancer During Chemotherapy With Capecitabine and Nab-Paclitaxel.
We report a case of disseminated superficial actinic porokeratosis (DSAP) in a 73-year-old woman with metastatic pancreatic cancer undergoing chemotherapy with capecitabine and nab-paclitaxel. This case suggests a possible association between DSAP and the use of these chemotherapeutic agents, emphasising the need for awareness of atypical dermatologic reactions in such patients.
Long-term disease control of disseminated superficial actinic porokeratosis (DSAP) with simvastatin 2%/ cholesterol 2% cream.
Disseminated superficial actinic porokeratosis (DSAP) is a rare keratinization disorder associated with an increased risk of cutaneous tumors. To develop a feasible and easy-to-apply treatment regimen for long-time disease control of DSAP including prevention of new skin tumors. 19 patients with DSAP were treated with 2% simvastatin/2% cholesterol (SC) cream for a maximum period of 18 months. Disease severity was assessed via Investigator Global Assessment (IGA), and quality of life (QoL) was measured using the Dermatology Life Quality Index (DLQI). Adverse events and tumor development were documented. Significant improvement in IGA scores was observed across all treated regions (p < 0.001), with most progress occurring in the first 3 months but maintained under a reduced proactive application schedule twice weekly. DLQI scores decreased significantly within the first 3 months. No new skin tumors developed during treatment. SC cream is a promising long-term, targeted treatment for DSAP, offering sustained efficacy, good tolerability, and improved QoL. The individual tapering from daily use to a proactive approach twice a week may be a key factor for disease control and may become an important component of skin tumor prevention in this specific patient population.
Topical Lovastatin/Cholesterol as a Potential Field-Directed Therapy for Disseminated Superficial Actinic Porokeratosis: A Case Report.
Disseminated superficial actinic porokeratosis (DSAP) is the most common subtype of porokeratoses, a rare group of disorders characterized by abnormal keratinization. Although the exact etiology is not fully understood, DSAP has been linked to genetic mutations in the mevalonate biosynthesis pathway. Based on this association, topical therapy with a combination of lovastatin and cholesterol has recently emerged as a promising treatment option. In this case study, we present a patient with extensive lower-extremity DSAP and a history of unsuccessful treatment with multiple traditional modalities, who was successfully treated with a 2% lovastatin/cholesterol formulation.
Disseminated Superficial Actinic Porokeratosis in a Mother and Daughter: A Case Report.
Porokeratosis is an autosomal dominant condition of epidermal keratinization. There are many clinical and morphological variants of porokeratosis, the most prevalent of which is disseminated superficial actinic porokeratosis (DSAP), which commonly affects photoexposed areas. Here, we present a 52-year-old woman and her 24-year-old daughter having similar complaints of gradually enlarging, annular hyperpigmented plaques on photoexposed areas suggesting familial transmission. Diagnosed as DSAP, treatment with oral isotretinoin and topical keratolytics showed significant improvement within one and a half months. This case report highlights familial DSAP cases in a mother and daughter, which is rare, emphasizing the importance of early diagnosis and management for better outcomes and reduced malignancy risk. Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. This condition represents 1 of 6 porokeratosis variants and involves more extensive distribution than most others. Linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis comprise the remaining 5 variants. Other rare forms include porokeratosis ptychotropica, facial porokeratosis, giant porokeratosis, hypertrophic verrucous porokeratosis, reticulate porokeratosis, and eruptive pruritic papular porokeratosis. The eruptive form has been linked to malignancy, immunosuppression, and a pro-inflammatory state. Lesions develop across the body. Risk factors for porokeratosis include genetic predisposition, immunosuppression, and ultraviolet light exposure. A defining feature of all porokeratosis variants is the cornoid lamella, which appears histologically as a column of parakeratotic cells. This structure is characterized by a raised ridge circumscribing porokeratotic lesions. DSAP lesions begin as pink to brown papules and macules with a raised border in sun-exposed areas. These lesions may be asymptomatic or mildly pruritic. DSAP is considered precancerous, with a 7.5% to 10% risk of malignant transformation to squamous cell carcinoma (SCC) or basal cell carcinoma (BCC). Multiple treatment options exist, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs (eg, calcipotriene), retinoids, and lasers.
Publicações recentes
Identification of two novel MVD mutations and one novel FDPS mutation in Chinese patients with porokeratosis.
Disseminated Superficial Actinic Porokeratosis in a Woman With Metastatic Pancreatic Cancer During Chemotherapy With Capecitabine and Nab-Paclitaxel.
Long-term disease control of disseminated superficial actinic porokeratosis (DSAP) with simvastatin 2%/ cholesterol 2% cream.
Topical Lovastatin/Cholesterol as a Potential Field-Directed Therapy for Disseminated Superficial Actinic Porokeratosis: A Case Report.
Porokeratosis ptychotropica: Diagnostic insights into a rare dermatosis.
📚 EuropePMC194 artigos no totalmostrando 96
Identification of two novel MVD mutations and one novel FDPS mutation in Chinese patients with porokeratosis.
Frontiers in medicineDisseminated Superficial Actinic Porokeratosis in a Woman With Metastatic Pancreatic Cancer During Chemotherapy With Capecitabine and Nab-Paclitaxel.
The Australasian journal of dermatologyLong-term disease control of disseminated superficial actinic porokeratosis (DSAP) with simvastatin 2%/ cholesterol 2% cream.
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDGTopical Lovastatin/Cholesterol as a Potential Field-Directed Therapy for Disseminated Superficial Actinic Porokeratosis: A Case Report.
CureusPorokeratosis ptychotropica: Diagnostic insights into a rare dermatosis.
JAAD case reportsCase Report: Rapid and Effective Treatment of Porokeratosis With Fractional CO2 Laser Combined With Topical 2% Cholesterol/Lovastatin Ointment.
Journal of cosmetic dermatologyDisseminated Superficial Actinic Porokeratosis in a Mother and Daughter: A Case Report.
CureusRepurposing guselkumab to target itch in disseminated superficial actinic porokeratosis: insights from RNA sequencing.
Clinical and experimental dermatologyTopical egg yolk oil (4% cholesterol) and oral rosuvastatin for the treatment of disseminated superficial actinic porokeratosis.
Indian journal of dermatology, venereology and leprologyDisseminated Superficial Actinic Porokeratosis Treated with Topical Simvastatin: Evaluation of Therapeutic Response with Dermoscopy.
Dermatology practical & conceptualPorokeratoses-A Rare Group of Dermatoses.
Medicina (Kaunas, Lithuania)Disseminated superficial actinic porokeratosis in an elderly patient undergoing androgen deprivation therapy for advanced prostate cancer: exploring the potential association.
Dermatology reportsDisseminated superficial actinic porokeratosis treated with tretinoin and calcipotriene.
JAAD case reportsDisseminated Superficial Actinic Porokeratosis: A Systematic Treatment Review.
American journal of clinical dermatologyLovastatin/cholesterol cream for the treatment of disseminated superficial actinic porokeratosis: a retrospective cohort study.
International journal of dermatologyA Clinico-Epidemiological Study on Porokeratosis.
Indian journal of dermatologyA case of porokeratosis with a variety of morphological manifestations.
Clinical case reportsPorokeratoses-A Comprehensive Review on the Genetics and Metabolomics, Imaging Methods and Management of Common Clinical Variants.
MetabolitesA Review of the Efficacy of Topical Statins for Treating Disseminated Superficial Actinic Porokeratosis.
Journal of drugs in dermatology : JDDBilateral Linear Porokeratosis Treated With Topical Lovastatin 2% Monotherapy.
CureusCharacteristics of glioblastomas and immune microenvironment in a Chinese family with Lynch syndrome and concurrent porokeratosis.
Frontiers in oncologyA Case of Disseminated Superficial Actinic Porokeratosis Successfully Treated With Topical Lovastatin/Cholesterol Gel.
CureusCase Report: A Novel MVK Missense Mutation in the Sporadic Porokeratosis Ptychotropica in China.
Clinical, cosmetic and investigational dermatologySafety and Efficacy of Topical Lovastatin Plus Cholesterol Cream vs Topical Lovastatin Cream Alone for the Treatment of Disseminated Superficial Actinic Porokeratosis: A Randomized Clinical Trial.
JAMA dermatologyLinear porokeratosis of the foot with dermoscopic manifestations: A case report.
World journal of clinical casesDisseminated superficial actinic porokeratosis following hydroxyurea treatment: A case report.
The Australasian journal of dermatologyPorokeratosis is one of the most common genodermatoses and is associated with an increased risk of keratinocyte cancer and melanoma.
Journal of the European Academy of Dermatology and Venereology : JEADVDisseminated Superficial Actinic Porokeratosis (DSAP): A Case Report Highlighting the Clinical, Dermatoscopic, and Pathology Features of the Condition.
CureusEffects of Blue Light on the Skin and Its Therapeutic Uses: Photodynamic Therapy and Beyond.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]Twists and turns of the genetic story of mevalonate kinase-associated diseases: A review.
Genes & diseasesMixed porokeratosis with a novel mevalonate kinase gene mutation: A case report.
World journal of clinical casesGrenz ray therapy in disseminated superficial actinic porokeratosis: A case series of 17 patients.
The Australasian journal of dermatologyNovel missense mutations of MVK and FDPS gene in Chinese patients with disseminated superficial actinic porokeratosis.
Clinica chimica acta; international journal of clinical chemistrySuccessful treatment of disseminated superficial actinic porokeratosis with topical 2% cholesterol/ 2% lovastatin cream: a case series with 7 patients.
Journal of the European Academy of Dermatology and Venereology : JEADVMutation Analysis of the MVD Gene in a Chinese Family with Disseminated Superficial Actinic Porokeratosis and a Chinese Literature Review.
Indian journal of dermatologyDermoscopy of porokeratosis: results from a multicentre study of the International Dermoscopy Society.
Journal of the European Academy of Dermatology and Venereology : JEADVTopical simvastatin-cholesterol for disseminated superficial actinic porokeratosis: An open-label, split-body clinical trial.
The Australasian journal of dermatologyManagement of disseminated superficial actinic porokeratosis and intraepidermal squamous cell carcinoma with low-dose radiation therapy.
The Australasian journal of dermatologyMevalonate Kinase-Associated Diseases: Hunting for Phenotype-Genotype Correlation.
Journal of clinical medicineCase of disseminated superficial actinic porokeratosis successfully treated with Q-switched ruby laser.
The Journal of dermatologyThe Malignancy Potential of Porokeratosis: A Single-Center Retrospective Study.
CureusPigmented disseminated superficial actinic porokeratosis in dark-skinned patients: Clinical, dermoscopic, and histopathologic features.
Journal of cosmetic dermatologyPorokeratosis Plantaris, Palmaris et Disseminata Caused by Con- genital Pathogenic Variants in the MVD Gene and Loss of Hetero-zygosity in Affected Skin.
Acta dermato-venereologicaNovel mutation in MVK gene for co-occurrence of disseminated superficial actinic porokeratosis with porokeratosis ptychotropica.
The Journal of dermatologyRefractory disseminated superficial actinic porokeratosis effectively treated with cholesterol/lovastatin cream: A case report.
Dermatologic therapyDrugs associated with development of porokeratosis: A systematic review.
Dermatologic therapyGeneralized type 2 segmental disseminated superficial actinic porokeratosis coexisted with multiple cutaneous squamous cell carcinomas: Analysis of two cases.
Indian journal of pathology & microbiologyEffective treatment of disseminated superficial actinic porokeratosis using a novel topical cholesterol/simvastatin combination cream.
The Australasian journal of dermatologyCholesterol partially rescues the inhibition effect of pravastatin on keratinocytes proliferation by regulating cell cycle relative proteins through AKT and ERK pathway.
Dermatologic therapyLichenoid inflammation of DSAP lesions following treatment with durvalumab, olaparib and paclitaxel: A potential diagnostic pitfall mimicking lichenoid drug eruptions associated with PDL-1 inhibitors.
Dermatology online journal[Dermoscopy of disseminated superficial actinic porokeratosis].
Annales de dermatologie et de venereologieEffects of mevalonate kinase interference on cell differentiation, apoptosis, prenylation and geranylgeranylation of human keratinocytes are attenuated by farnesyl pyrophosphate or geranylgeranyl pyrophosphate.
Experimental and therapeutic medicineLooking horizontally at disseminated superficial actinic porokeratosis: Correlations between in-vivo reflectance confocal microscopy and histopathology.
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)Second-Hit Somatic Mutations in Mevalonate Pathway Genes Underlie Porokeratosis.
The Journal of investigative dermatologyA precancerous skin lesion that is often misdiagnosed.
Australian journal of general practiceTopical cholesterol/lovastatin for the treatment of porokeratosis: A pathogenesis-directed therapy.
Journal of the American Academy of DermatologyNovel mutation for disseminated superficial actinic porokeratosis and its functional impact at the protein level.
The British journal of dermatologyTwo novel SSH1 mutations in Chinese patients with disseminated superficial actinic porokeratosis and immunohistochemical analysis of anti-Slingshot homolog 1 antibody in one typical patient.
Journal of the European Academy of Dermatology and Venereology : JEADVClonal Expansion of Second-Hit Cells with Somatic Recombinations or C>T Transitions Form Porokeratosis in MVD or MVK Mutant Heterozygotes.
The Journal of investigative dermatologySuperficial shaving combined with photodynamic therapy for treating disseminated superficial actinic porokeratosis: A case report.
Photodiagnosis and photodynamic therapyEffective treatment of disseminated superficial actinic porokeratosis with chemical peels - customary treatment for a rare disease.
The Journal of dermatological treatmentMultiple flat-topped scaly violaceous papules.
Dermatology online journalNovel mutations in mevalonate kinase cause disseminated superficial actinic porokeratosis.
The British journal of dermatologyA novel premature termination mutation in FDPS in a Chinese family with disseminated superficial actinic porokeratosis.
The British journal of dermatologyImproved effect on 2 cases of disseminated superficial actinic porokeratosis with daylight photodynamic therapy.
Photodiagnosis and photodynamic therapyNovel mevalonate kinase missense mutation in a patient with disseminated superficial actinic porokeratosis.
JAAD case reportsTemozolomide-induced inflammation of disseminated superficial actinic porokeratosis.
Dermatology online journalA report and follow up of a patient with disseminated superficial actinic porokeratosis (DSAP) undergoing novel systemic treatment with palifermin (a keratinocyte growth factor) during chemotherapy.
Dermatology online journalDisseminated Superficial Actinic Porokeratosis in a Vitiligo Patient Undergoing Treatment with Long-Term Narrowband Ultraviolet B.
Annals of dermatologyDisseminated Superficial Actinic Porokeratosis in a Patient with Psoriasis, after Long-Term Narrowband Ultraviolet B Phototherapy.
Annals of dermatologyAmelanotic melanoma arising within a lesion of disseminated superficial actinic porokeratosis: An unusual presentation leading to a novel therapeutic approach.
Dermatologic therapyClinical and Dermoscopic Features of Pigmented Disseminated Superficial Actinic Porokeratosis: Case Report and Literature Review.
Journal of cutaneous medicine and surgerySuccessful Use of Grenz Rays for Disseminated Superficial Actinic Porokeratosis: Report of 8 Cases.
Dermatology (Basel, Switzerland)Treatment of disseminated superficial actinic porokeratosis with oral alitretinoin.
Journal of the European Academy of Dermatology and Venereology : JEADVA novel non-frameshift deletion in MVK gene responsible for disseminated superficial actinic porokeratosis in one Chinese family.
Journal of the European Academy of Dermatology and Venereology : JEADVDisseminated superficial actinic porokeratosis treated with ingenol mebutate gel 0.05.
CutisFollicular Porokeratosis, a Porokeratosis Variant.
The American Journal of dermatopathologyLight and laser treatment modalities for disseminated superficial actinic porokeratosis: a systematic review.
Lasers in medical scienceMultiple actinic keratoses induced by occupational UV exposure in a patient with preexisting disseminated superficial actinic porokeratosis (Chernosky-Freeman).
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDGSuccessful management of disseminated superficial actinic porokeratosis with diclofenac sodium 3% gel.
Dermatologic therapy[Circumscribed palmar hypokeratosis (CPM): The diagnostic value of dermoscopy].
Annales de dermatologie et de venereologiePorokeratosis ptychotropica: a rare manifestation with typical histological exam.
Anais brasileiros de dermatologiaTwo cases of disseminated superficial actinic porokeratosis treated with daylight-mediated photodynamic therapy.
Dermatologic therapyDisseminated superficial actinic porokeratosis (DSAP): significant improvement after local administration of calcipotriol/betamethasone gel?
Wiener medizinische Wochenschrift (1946)[Disseminated superficial actinic porokeratosis in a pedigree].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical geneticsLinear porokeratosis with multiple squamous cell carcinomas successfully treated by electrochemotherapy.
The British journal of dermatologyDisseminated superficial porokeratosis involving the groin and genitalia in a 72-year-old immunocompetent man.
JAAD case reportsDermoscopy of Disseminated Superficial Actinic Porokeratosis.
Actas dermo-sifiliograficasDisseminated Superficial Actinic Porokeratosis.
Actas dermo-sifiliograficasDisseminated superficial actinic porokeratosis improved with fractional 1927-nm laser treatments.
Journal of cosmetic and laser therapy : official publication of the European Society for Laser DermatologyIdentification of three mutations in the MVK gene in six patients associated with disseminated superficial actinic porokeratosis.
Clinica chimica acta; international journal of clinical chemistryPremalignant and Malignant Skin Lesions in Two Recipients of Vascularized Composite Tissue Allografts (Face, Hands).
Case reports in transplantationDisseminated superficial actinic porokeratosis accentuated by spray tan.
International journal of dermatologyPorokeratosis - Head to toe: An unusual presentation.
Indian dermatology online journalEruptive disseminated porokeratosis associated with corticosteroid-induced immunosuppression.
Clinical and experimental dermatologyDisseminated superficial actinic porokeratosis in a psoriasis patient with a long-term sun-bathing habit.
The Journal of dermatologyAssociações
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Comunidades
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Identification of two novel MVD mutations and one novel FDPS mutation in Chinese patients with porokeratosis.
- Disseminated Superficial Actinic Porokeratosis in a Woman With Metastatic Pancreatic Cancer During Chemotherapy With Capecitabine and Nab-Paclitaxel.
- Long-term disease control of disseminated superficial actinic porokeratosis (DSAP) with simvastatin 2%/ cholesterol 2% cream.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG· 2025· PMID 41318917mais citado
- Topical Lovastatin/Cholesterol as a Potential Field-Directed Therapy for Disseminated Superficial Actinic Porokeratosis: A Case Report.
- Disseminated Superficial Actinic Porokeratosis in a Mother and Daughter: A Case Report.
- Porokeratosis ptychotropica: Diagnostic insights into a rare dermatosis.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:79152(Orphanet)
- MONDO:0019212(MONDO)
- GARD:10983(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Q5282749(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
