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Síndrome de dificuldade respiratória aguda do lactente
ORPHA:70587CID-10 · P22.0CID-11 · KB23.0OMIM 267450DOENÇA RARA

A síndrome do desconforto respiratório agudo infantil é um distúrbio pulmonar que afeta bebês prematuros, causado pela insuficiência de desenvolvimento da produção de surfactante e pela imaturidade estrutural dos pulmões. Os sintomas geralmente aparecem logo após o nascimento e podem incluir taquipneia, taquicardia, retrações (recessão) da parede torácica, grunhidos expiratórios, dilatação nasal e cianose durante esforços respiratórios.

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Introdução

O que você precisa saber de cara

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A síndrome do desconforto respiratório agudo infantil é um distúrbio pulmonar que afeta bebês prematuros, causado pela insuficiência de desenvolvimento da produção de surfactante e pela imaturidade estrutural dos pulmões. Os sintomas geralmente aparecem logo após o nascimento e podem incluir taquipneia, taquicardia, retrações (recessão) da parede torácica, grunhidos expiratórios, dilatação nasal e cianose durante esforços respiratórios.

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SUS: Sem cobertura SUSScore: 0%
CID-10: P22.0
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Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

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Pulmão
4 sintomas
❤️
Coração
1 sintomas

+ 7 sintomas em outras categorias

Características mais comuns

Edema
Atelectasia
Desconforto respiratório
Dispneia
Desconforto respiratório neonatal
Nascimento prematuro
12sintomas
Sem dados (12)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 12 características clínicas mais associadas, ordenadas por frequência.

Edema
AtelectasiaAtelectasis
Desconforto respiratórioRespiratory distress
DispneiaDyspnea
Desconforto respiratório neonatalNeonatal respiratory distress

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Anos de pesquisa1
Últimos 10 anos200publicações
Pico2025113 papers
Linha do tempo
2025Hoje · 2026🧪 1984Primeiro ensaio clínico
Publicações por ano (últimos 10 anos)

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Genética e causas

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🇧🇷 Atendimento SUS — Síndrome de dificuldade respiratória aguda do lactente

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Publicações mais relevantes

Timeline de publicações
0 papers (10 anos)
#1

Prognostic significance of serum apelin-13 and galectin-3 concentrations as potential indicators of severity and mortality in pediatric acute respiratory distress syndrome.

The Turkish journal of pediatrics2026 Feb 27

Este estudo investigou biomarcadores na Síndrome de Dificuldade Respiratória Aguda Pediátrica (SDRAp), revelando que os níveis séricos de galectina-3 são significativamente mais elevados em pacientes e aumentam com a gravidade da doença. Crucialmente, a galectina-3 foi o único preditor independente de mortalidade, enquanto os níveis de apelin-13, embora relacionados à gravidade, não mostraram o mesmo valor prognóstico. Para médicos, isso indica que a galectina-3 pode ser uma ferramenta promissora para avaliar a gravidade da SDRAp e o risco de mortalidade em crianças.

🇧🇷 traduzido
#2

Time to initiate trophic feeding and predictors among preterm neonates admitted at General Hospitals in Tigray, 2025.

PloS one2026

Este estudo revela um atraso significativo na introdução da alimentação trófica para neonatos prematuros (mediana de 45 horas versus 24 horas recomendadas), o que se associa a maior mortalidade e restrição de crescimento. Fatores como baixo peso ao nascer, baixos escores de APGAR, **a presença de síndrome do desconforto respiratório (SDR)** e a ausência do método canguru (KMC) foram identificados como preditores desse atraso. Para médicos e pacientes, é crucial que as instituições de saúde foquem na gestão desses fatores, especialmente em neonatos com SDR, para acelerar o início da alimentação e mitigar complicações.

🇧🇷 traduzido
#3

Neonatal hypoxic-ischemic encephalopathy online registry in Shenzhen: protocol for a multicentre, prospective, open, observational cohort study.

BMJ open2026 Mar 18

Este estudo estabelece um registro prospectivo em Shenzhen, China, para acompanhar bebês com Encefalopatia Hipóxico-Isquêmica (HIE), uma das principais causas de deficiência neurológica neonatal. Ele coletará dados sobre fatores de risco, a eficácia da terapia de hipotermia e o desenvolvimento neurológico a longo prazo, monitorando também a incidência de complicações sérias como a Síndrome do Desconforto Respiratório Agudo Neonatal (NARDS). O objetivo é aprimorar o conhecimento sobre a HIE para otimizar o tratamento e reduzir as sequelas e deficiências associadas, beneficiando diretamente pacientes e a prática médica.

🇧🇷 traduzido
#4

High-Frequency Oscillation vs Mechanical Ventilation for Neonatal Acute Respiratory Distress Syndrome: A Randomized Clinical Trial.

JAMA network open2026 Mar 02

Em um ensaio clínico randomizado com bebês prematuros com Síndrome do Desconforto Respiratório Agudo Neonatal (NARDS), a ventilação oscilatória de alta frequência (HFOV) demonstrou ser superior à ventilação mecânica convencional (CMV) na redução da displasia broncopulmonar (DBP). A HFOV reduziu a incidência de DBP em até 32% sem aumentar o risco de outras complicações graves, como morte, hemorragia intraventricular ou enterocolite necrosante. Isso sugere que a HFOV é uma estratégia promissora para prevenir a DBP nesta população de alto risco, oferecendo uma opção de tratamento potencialmente melhor para pacientes e médicos.

🇧🇷 traduzido
#5

Drying Very Preterm Infants Before Plastic Wrapping at Birth: A Randomized Clinical Trial.

JAMA network open2026 Mar 02

Este estudo clínico randomizado investigou se secar bebês prematuros antes de envolvê-los em plástico no nascimento melhora a manutenção da temperatura corporal. Os resultados mostraram que secar antes do envolvimento com plástico não ofereceu benefício adicional para atingir a normotermia na admissão à UTI neonatal, com quase metade dos bebês ainda fora da faixa térmica ideal em ambos os grupos. Isso indica que, para médicos e pacientes, o manejo térmico de prematuros continua sendo um desafio complexo que necessita de mais investigações.

🇧🇷 traduzido

Publicações recentes

Ver todas no PubMed

📚 EuropePMCmostrando 199

2026

Prognostic significance of serum apelin-13 and galectin-3 concentrations as potential indicators of severity and mortality in pediatric acute respiratory distress syndrome.

The Turkish journal of pediatrics
2026

Time to initiate trophic feeding and predictors among preterm neonates admitted at General Hospitals in Tigray, 2025.

PloS one
2026

Sustained Lung Inflation in Preterm Infants with Signs of Respiratory Distress: A Randomized Controlled Trial.

Advanced biomedical research
2026

Neonatal hypoxic-ischemic encephalopathy online registry in Shenzhen: protocol for a multicentre, prospective, open, observational cohort study.

BMJ open
2026

Aortic isthmus Doppler hemodynamics and ımpacts on perinatal outcomes in pregestational and gestational diabetes mellitus.

Archives of gynecology and obstetrics
2026

Elevated Driving Pressure in Pressure-Controlled Ventilation: An Independent Risk Factor for Adverse Outcomes in Mechanically Ventilated Neonates.

Lung
2026

Prevention of Pressure Injuries During Nasal Continuous Positive Airway Pressure in Newborns: A Non-pharmacological Intervention Trial.

Nursing in critical care
2026

Fatal Hemorrhagic Rupture of a Cystic Hepatic Hemangioma in a 27-Week Preterm Neonate.

Cureus
2026

Neonatal Bradypnea as an Under-Recognized Manifestation of Prader-Willi Syndrome: A Case Report.

Cureus
2026

The effect of gestational diabetes on maternal and neonatal outcomes.

Taiwanese journal of obstetrics & gynecology
2026

A Prospective-Retrospective Observational Cohort Study of Short-Term Health Outcomes of Preterm Very Low Birth Weight Infants Receiving Oropharyngeal Administration of Own Mother's Colostrum.

Current therapeutic research, clinical and experimental
2026

Perinatal Transmission of Dengue Virus Type 2 in Northern Argentina: A Series of 6 Cases.

The Pediatric infectious disease journal
2026

The Value of Cord Blood CXCL10 and MMP8 as Biomarkers in Predicting Bronchopulmonary Dysplasia- A Retrospective Cohort Study.

International journal of general medicine
2026

European Consensus Guidelines on the Management of Respiratory Distress Syndrome - 2025.

Neonatology
2026

High-Frequency Oscillation vs Mechanical Ventilation for Neonatal Acute Respiratory Distress Syndrome: A Randomized Clinical Trial.

JAMA network open
2026

A Predictive Model for Moderate or Severe Neonatal Acute Respiratory Distress Syndrome in Extremely Preterm Infants with Premature Rupture of Membranes: Development and Internal Validation.

Journal of inflammation research
2026

Hypercapnia as a Key Mechanism in the Development of Pulmonary Hypertension in Malignant Pertussis: A Case Report.

Respirology case reports
2026

An Unusual Case of Situs Inversus in a Premature Neonate.

Cureus
2025

A Novel Mutation in DDR2 Associated with Warburg-Cinotti Syndrome in a Neonate.

Archives of Iranian medicine
2026

Genetic features of Japanese children with ABCA3 deficiency.

Early human development
2026

Drying Very Preterm Infants Before Plastic Wrapping at Birth: A Randomized Clinical Trial.

JAMA network open
2026

The high-risk minority: undetected preterm SGA disproportionately contributes to adverse outcomes in a Chinese cohort.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
2026

Efficacy evaluation of pulmonary surfactant guided by lung ultrasound score in neonatal respiratory distress syndrome: a prospective observational study in Ganzi Tibetan Autonomous Prefecture.

Journal of tropical pediatrics
2026

Impact of timing from last dose of dexamethasone administration to delivery, different steroid courses, and fetal number on preterm neonatal outcomes.

PloS one
2026

Neonatal Mortality in Low-Birth-Weight Infants in Southern Ethiopia: A Multicenter Cohort Study With Multilevel Analysis.

Sage open pediatrics
2026

The influence of miR-1246 on the clinical outcomes of neonatal respiratory distress syndrome.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
2026

Comparison of two strategies to prevent preterm birth in twins complicated by cervical insufficiency: a retrospective cohort study.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
2026

Congenital cervical neuroblastoma presenting with spontaneous tumour lysis syndrome and severe neonatal airway compromise.

BMJ case reports
2026

Basic Ventilator Graphics in the NICU: A Practical Overview.

NeoReviews
2026

Early lung ultrasound score combined with umbilical cord-blood procalcitonin improves 1-year prognostic stratification in preterm neonates with respiratory distress syndrome.

Frontiers in pediatrics
2026

Electrical Activity of the Diaphragm (Edi) Metrics in Premature Infants Receiving Invasive Mechanical Ventilation Versus Noninvasive Respiratory Support.

Cureus
2026

Defining the Timing Window: Week- and Interval-Specific Effects of Antenatal Betamethasone in Late-Preterm Births.

Journal of clinical medicine
2026

Clinical Application of Inhaled Nitric Oxide in Conditions of Excessive Right Heart Load: A Review from Neonatal Pulmonary Hypertension to Perioperative Cardiac Surgery Management.

Journal of cardiovascular development and disease
2026

Nasal high-frequency oscillatory ventilation versus nasal continuous positive airway pressure for respiratory distress syndrome in preterm infants: A systematic review and meta-analysis.

European journal of pediatrics
2026

Predicting neonatal respiratory distress syndrome in late preterm infants.

BMC pregnancy and childbirth
2026

Differences in healthcare resource utilization by race/ethnicity among moderate to late preterm infants with respiratory distress Syndrome, Northern California.

Journal of perinatology : official journal of the California Perinatal Association
2026

Outcomes of noninvasive versus invasive respiratory support in pediatric scrub typhus-associated acute respiratory failure: a retrospective cohort study from South India.

Journal of tropical pediatrics
2026

Stridor as an Initial Manifestation of Underlying PHACE Syndrome in an Infant: A Case Report and Comprehensive Review.

Clinical medicine insights. Pediatrics
2026

Surfactant therapy in neonatal care: advances, challenges, and practical considerations.

European journal of pediatrics
2026

Antenatal Corticosteroids for Fetal Maturation: A Comprehensive Review of Major Guidelines.

Obstetrical & gynecological survey
2025

Factors Associated With PICU Admission In Children With Multisystem Inflammatory Syndrome (MIS-C): An Observational Cohort Study.

La Tunisie medicale
2026

Mendelian randomization analysis of labor anesthesia and adverse neonatal outcomes.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
2026

Second report of registry of the International Society of Uterus Transplantation (ISUTx): international activities 2000-2024.

Human reproduction (Oxford, England)
2026

Severe respiratory syncytial virus bronchiolitis complicated by profound hyponatremia and seizures in an infant: a case report.

AME case reports
2026

Cardiofaciocutaneous Syndrome Type 4 due to a MAP2K2 Variant: Expanding the Phenotypic Spectrum With Feeding Dysfunction and Neurodevelopmental Involvement.

Clinical case reports
2026

Case report of breastfeeding after maternal iodine contrast: neonatal hypothyroidism revealing an underlying congenital disorder.

International breastfeeding journal
2026

Human Milk and Infant Gut Microbiome in Association With Infant Fecal Metabolome and Child Blood Pressure.

JAMA network open
2026

Open Fetal Versus Postnatal Repair of Spina Bifida Aperta-A Comparison of Neonatal Outcomes.

Prenatal diagnosis
2025

Elective HFOV vs CMV as Early Intervention: A Clinical Trial in Neonates with Acute Respiratory Distress Syndrome.

Advanced biomedical research
2026

Incidence and outcome of major perinatal comorbidities of all hospitalized neonates requiring intensive and critical care: a livebirth population-based survey.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
2026

COVID-19 and Neonatal Guillain-Barré Syndrome: Exploring a Possible Causal Link With Review of Literature.

Journal of child neurology
2026

Dexmedetomidine for LISA procedure: a prospective observational single center experience.

Italian journal of pediatrics
2026

Early-onset preeclampsia: gestational age threshold of potential benefits.

European journal of obstetrics, gynecology, and reproductive biology
2026

Risk factors for pulmonary hemorrhage of very low birth weight infants: a meta-analysis.

Italian journal of pediatrics
2025

Case Report: Clinical characteristics and multidisciplinary collaborative management of congenital tuberculosis in extremely preterm twins and preterm infants: a report of three cases and literature review.

Frontiers in pediatrics
2026

Desaturations with or without Bradycardia Are Associated with Cerebral and Abdominal Hypoxemia: Secondary Analysis of a Randomized Clinical Trial.

Neonatology
2025

Risk factors for hemodynamically significant patent ductus arteriosus and ibuprofen treatment failure in premature twins: a retrospective case-control study.

Frontiers in cardiovascular medicine
2026

Predictors of Mortality in Preterm Infants with Respiratory Distress Syndrome: A Retrospective Analysis.

Journal of clinical medicine
2026

Non-Invasive Surfactant Administration in Preterm Infants.

Children (Basel, Switzerland)
2025

Can We Use Simple Radiographic Measurements to Predict Need for Intervention in Neonatal Pneumothorax?

Children (Basel, Switzerland)
2026

Whole blood resuscitation is associated with decreased end-organ dysfunction in pediatric trauma patients.

The journal of trauma and acute care surgery
2026

The Effect of Vitamin A and Retinol-Binding Protein Levels in Cord Blood of Very Low Birth Weight Infants on Mortality and Morbidity.

Klinische Padiatrie
2026

[Impact of antenatal corticosteroids on respiratory morbidities in late preterm infants born to mothers with gestational diabetes mellitus].

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
2026

Coronavirus disease 19 death among infants with complications of severe acute malnutrition, Kenema district, Sierra Leone, June 2020: a case series.

Journal of medical case reports
2026

Utilization of integrated lung ultrasound and targeted neonatal echocardiography in preterm infant follow-up: is it feasible? Assessing value and practical challenges.

European journal of pediatrics
2026

Chitayat Syndrome: A Rare Case of Respiratory Distress in a Preterm Infant.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
2026

Validation of a new Japanese classification for predicting severe bronchopulmonary dysplasia in preterm infants.

Clinical and experimental pediatrics
2026

Pregnant women with MDR/RR-TB and the all-oral 6-month regimen: experiences from a patient series in South Africa.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2026

Clinical characteristics, risk factors, and prognostic modeling for poor outcomes in children with influenza-associated encephalopathy: A retrospective cohort study.

Medicine
2025

Development and validation of a nomogram to predict bronchopulmonary dysplasia in very preterm, very low birth weight infants.

American journal of translational research
2025

Bubble CPAP in neonatal care: mechanisms, evidence, and pathways to optimization.

Paediatric respiratory reviews
2026

Newborn Respiratory Distress: Evaluation and Management.

American family physician
2026

Initial supplementary oxygen concentration for moderate-late preterm infants receiving respiratory support in the delivery room: statistical analysis plan for the multicenter, cluster-randomized crossover AIROPLANE Trial.

Trials
2026

Primary pulmonary hypoplasia masquerading as pneumonia in a preterm neonate and creating a diagnostic challenge: a case report.

Journal of medical case reports
2025

Effectiveness of Delivery Room Continuous Positive Airway Pressure in Term Neonates With Respiratory Distress: A Single-Center Experience.

Cureus
2026

A clinical study on the construction of a prenatal ultrasound-based predictive model for fetal lung maturity in late pregnancy using propensity score matching.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
2026

Unraveling the Connection Between Respiratory Distress and Hypertension in an 18-Month-Old Girl.

Chest
2026

Perioperative nursing care for a parturient with hypertriglyceridemic acute pancreatitis undergoing cesarean section: A case report.

Medicine
2026

Respiratory Physiotherapy in Preterm Neonates with Bronchopulmonary Dysplasia or Respiratory Distress Syndrome: A Comprehensive Review of Clinical Evidence and Therapeutic Implications.

Journal of clinical medicine
2025

Late-Preterm and Early-Term Respiratory Morbidity in Infants Born Primarily via Elective Caesarean Section.

Journal of clinical medicine
2026

Epidemiology, clinical outcomes and mortality-associated factors of staphylococcal pneumonia in hospitalized Thai children: A nationwide retrospective analysis 2015-2023.

Journal of infection and public health
2026

The Impact of Offspring Sex on Pregnancy and Neonatal Outcomes in Individuals with Pregestational Diabetes.

American journal of perinatology
2026

The impact of antenatal corticosteroids on respiratory and metabolic outcomes in late-preterm births depends on timing, number of courses, and singleton/twin status: a retrospective cohort study.

BMC pregnancy and childbirth
2026

Validation of plasma soluble receptor of advanced glycation end-products and angiopoietin-2 in paediatric acute respiratory distress syndrome.

BMJ open respiratory research
2025

The relationship of p50 with clinical outcomes in ventilated preterm infants.

Frontiers in pediatrics
2026

Effectiveness and feasibility of orogastric tube for surfactant delivery in moderate or very preterm neonates with respiratory distress syndrome: an open-label randomized controlled trial.

Journal of tropical pediatrics
2025

Comparison of the effect of surfactant with and without budesonide on the outcomes of respiratory distress syndrome (RDS) in premature infants: a randomized control trial.

BMC pregnancy and childbirth
2026

Phenotypic continuum in IGHMBP2-related disorders: a portfolio of cases from typical to Guillain-Barré syndrome-like presentation.

Neuromuscular disorders : NMD
2025

Pulmonary Pseudosequestration in a Child with Down Syndrome.

Children (Basel, Switzerland)
2025

Prospective, Non-Blinded, Randomized Controlled Trial of Pulmonary Surfactant Administration Guided by Lung Ultrasound in Preterm Infants with Gestational Age < 32 Weeks.

Children (Basel, Switzerland)
2025

Oxidant Stress, Hyperoxia/Hypoxia and Neonatal Respiratory Disorders.

Antioxidants (Basel, Switzerland)
2025

Spectral analysis of gastric aspirates obtained shortly after birth predicts the need for prolonged respiratory support in neonates in a development cohort.

Frontiers in pediatrics
2025

En caul cesarean section for extremely low birth weight infants: a single-center, retrospective study.

BMC pregnancy and childbirth
2026

Impact of Antenatal Dexamethasone on Respiratory Outcomes in Late Preterm Infants in a Vietnamese Tertiary Hospital: A Randomised Controlled Trial.

Acta paediatrica (Oslo, Norway : 1992)
2025

Methodological Considerations in the Comparison of INSURE and LISA in Very Preterm Infants.

Neonatology
2025

Initial supplementary oxygen concentration for moderate-late preterm infants receiving respiratory support in the delivery room: study protocol for the multicenter, cluster-randomized, crossover AIROPLANE trial.

Trials
2025

Respiratory support during neonatal and infant aeromedical interfacility transfers in the Western Cape, South Africa: a retrospective review.

BMC emergency medicine
2026

Primary Hemophagocytic Lymphohistiocytosis: A Severe Immune Dysregulatory Disease with Various Genotypic Features and Outcomes: A Cross-Sectional Study from a Tertiary Pediatric Center.

Turkish journal of haematology : official journal of Turkish Society of Haematology
2025

[The Characteristics of Course of Pregnancy and Perinatal Outcomes in Women with Gestation Diabetes Mellitus (The Results of Ten-Years Research)].

Problemy sotsial'noi gigieny, zdravookhraneniia i istorii meditsiny
2025

Efficacy of pulmonary surfactant with budesonide in infants born at or less than 28 weeks' gestation: a systematic review and meta-analysis.

Scientific reports
2025

Low invasive surfactant administration by videolaringoscopy: a feasibility study.

Italian journal of pediatrics
2025

Neonatal respiratory care in Vietnam: surfactant use and clinical practices in a large neonatal intensive care unit.

BMC pediatrics
2025

Case reports of pregnancies in women with Shone syndrome: role for multidisciplinary planning.

European heart journal. Case reports
2026

Identification of a De Novo MAGEL2 Pathogenic Variant in Schaaf-Yang Syndrome and the Importance of Paternal Allele Confirmation.

Journal of clinical laboratory analysis
2025

Neonatal severe hypertriglyceridaemia: A novel lipoprotein lipase gene splicing variant.

BMJ case reports
2025

Development and validation of a pre-trained language model for neonatal morbidities: a retrospective, multicentre, prognostic study.

The Lancet. Digital health
2025

Diaphragm dysfunction and interstitial lung disease in a preterm infant.

BMJ case reports
2025

Expanding the literature on Cantú syndrome: recognising early clinical and phenotypic clues.

BMJ case reports
2025

nSOFA scores predict prolonged mechanical ventilation in neonatal respiratory distress syndrome: a retrospective cohort study.

BMC pediatrics
2025

Neurodevelopmental outcomes in children and adults associated with antenatal corticosteroid exposure: a narrative review.

European journal of pediatrics
2025

Prevalence of respiratory distress syndrome among late preterm infants admitted to a neonatal intensive care unit in Saudi Arabia: A retrospective study.

Saudi medical journal
2025

Respiratory distress syndrome in late preterm infants: Are we doing enough to prevent it?

Saudi medical journal
2025

[Development of dynamic multi-time-point clinical prediction models for bronchopulmonary dysplasia in preterm infants with gestational age < 32 weeks].

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
2025

Guidelines for performing and reporting neonatal lung ultrasound in Mexico.

Boletin medico del Hospital Infantil de Mexico
2025

Use of lung ultrasound to guide surfactant administration and make differential diagnosis during immediate and transitional newborn care in a perinatal hospital.

Boletin medico del Hospital Infantil de Mexico
2026

Risk factors for ICD-10-coded Respiratory Syncytial Virus-associated deaths in hospitalized patients in Germany before the COVID-19 pandemic (nationwide in-patient data, 2010-2019).

Infection
2025

Comparisons of fecal microbiota and cytokines in preterm infants preceding necrotizing enterocolitis and feeding intolerance: An observational study.

Medicine
2025

Dexamethasone dosage and course effects on respiratory outcomes in preterm twins: retrospective cohort study.

Scientific reports
2025

Complete Pancreatic Agenesis Presenting With Neonatal Diabetes and Exocrine Insufficiency: A Case Report.

Cureus
2025

Association of antenatal dexamethasone administration timing with outcomes in preterm infants in a low- and middle-income country.

Frontiers in medicine
2025

Clinical-radiological profile and risk factors for early mortality in preterm neonates with respiratory distress syndrome in Hoima, Western Uganda.

Scientific reports
2025

Predictors of early newborn deaths at Dar es Salaam public regional referral hospitals: A prospective observational hospital-based study.

PloS one
2025

Management of Neonatal Severe Hyperparathyroidism due to Homozygous CASR Mutation: Challenges and Literature Insights.

Molecular syndromology
2025

Base excess serves as a mediator in the hemoglobin-intensive care unit stay length relationship in neonatal respiratory distress syndrome.

Translational pediatrics
2025

Effectiveness of surfactant treatment and retreatment in moderately preterm infants.

Translational pediatrics
2025

Intratracheal Budesonide Combined With Surfactant for Pulmonary Hemorrhage in a Preterm Neonate: A Case Report.

Cureus
2025

Diaphragmatic ultrasound and thoracic fluid content for prediction of non-invasive ventilation failure in neonates: a randomized controlled trial.

European journal of pediatrics
2026

Respiratory Involvement in HIST1H1E-Related Rahman Syndrome: A Case of Severe Mixed Apnea.

American journal of medical genetics. Part A
2025

Diaphragmatic Hernia in a Newborn With COL1A1-Associated Classical Ehlers-Danlos Syndrome.

Case reports in genetics
2026

Association between FAR, PAR, APRI and adverse neonatal outcomes in pregnancies complicated by intrahepatic cholestasis.

Journal of perinatal medicine
2025

Newborns with ARDS originating from sepsis of extrapulmonary origin exhibit worse prognoses: findings from a multicenter study in China.

European journal of pediatrics
2025

Fetal inflammatory response severity on placental histology identifies neonates at risk for meconium aspiration syndrome.

Pediatric research
2025

Did COVID-19 impact perinatal outcomes differently in public and private maternity hospitals in Brazil?

Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia
2025

Impact of delayed cord clamping and minimally invasive surfactant administration on outcomes in premature infants with neonatal respiratory distress syndrome at less than 30 weeks gestation: a NICU quality improvement study.

Frontiers in pediatrics
2025

A randomized controlled equivalence trial of pulmonary surfactant administration via laryngeal mask airway versus endotracheal intubation.

Trials
2025

SurfON trial: study protocol for a multicentre, open-label, randomised controlled trial of early surfactant therapy versus expectant management in late preterm and early term infants with respiratory distress.

Trials
2025

Nomogram-based prediction model for extubation failure in preterm infants with invasive mechanical ventilation.

Italian journal of pediatrics
2025

Pulmonary comorbidities and response to surfactant in late preterm infants: a multicenter cohort study.

Pediatric research
2025

Photobiomodulation therapy enhances surfactant production in premature rat lungs: a non-invasive therapeutic strategy for neonatal respiratory distress syndromes.

Photochemical &amp; photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
2025

Viral-associated septic shock in pediatric pneumonia: a retrospective analysis of pathogen-specific risks and comparative clinical features with bacterial sepsis.

Frontiers in pediatrics
2025

Flow-Driver-Generated Synchronized Nasal Intermittent Positive-Pressure Ventilation Versus Biphasic Positive Airway Pressure After Extubation in Preterm Infants.

Pediatric pulmonology
2025

Impact of kangaroo mother care on continuous positive airway pressure success in preterm newborns: a randomized controlled trial.

Journal of tropical pediatrics
2025

[Benefits and risks of antenatal corticosteroids].

Gynecologie, obstetrique, fertilite &amp; senologie
2026

MIST/LISA in Portugal: National Survey of Clinical Practice.

Journal of paediatrics and child health
2025

Funisitis Predicts Poor Respiratory Outcomes in Extremely Preterm Neonates.

Children (Basel, Switzerland)
2025

Antenatal Corticosteroids and Bronchopulmonary Dysplasia in Very Preterm Infants.

JAMA network open
2025

Clinical determinants of time to full enteral feeding in preterm infants with neonatal respiratory distress syndrome: a retrospective cohort study.

BMC pediatrics
2025

Higher (40%) versus lower (30%) FiO2 threshold for surfactant administration in preterm neonates between 26 and 32 weeks of gestational age: a non-inferiority randomized controlled trial.

European journal of pediatrics
2025

A systematic scoping review of the use of surfactant replacement therapy for respiratory distress syndrome in preterm neonates in low- and middle-income countries.

Frontiers in pediatrics
2026

Multicentre investigation of Wickerhamomyces anomalus fungemia in India: emerging resistance and mechanistic insights.

The Journal of antimicrobial chemotherapy
2025

Commentary on: Comparison of Bovine Lipid Extract Surfactant and Poractant Alfa Administered via LISA in Preterm Infants (28 + 0 to 34 + 6 Week) With Respiratory Distress Syndrome: A Randomized Controlled Trial.

Pediatric pulmonology
2025

Comparison of Ventilator-Derived and Modified Bubble Continuous Positive Airway Pressure for Early Stabilization of Transient Tachypnea of the Newborn: A Retrospective Cohort Study in a Transitional Care Unit.

Turkish archives of pediatrics
2025

The Hidden Metabolic Threat: A Case of Fatty Acid Oxidation Disorder Masquerading as Viral Myocarditis.

Cureus
2025

Higher PEEP reduces duration of mechanical ventilation in neonatal respiratory distress syndrome of late preterm and term newborn infants.

Scientific reports
2025

[Neuropsychological development status and risk factors in small for gestational age infants at corrected ages 12-24 months].

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
2025

Development and validation of a nomogram for predicting necrotizing enterocolitis in premature infants with early-onset sepsis.

Scientific reports
2025

Non-invasive open lung strategy in delivery room: randomized controlled trial (OpenCPAP-DR).

European journal of pediatrics
2025

Evaluation of the Predictive Value of Lung Ultrasound Scoring Systems in Assessing Bronchopulmonary Dysplasia Severity Among Preterm Infants: Correlation Analysis with Therapeutic Strategies and Clinical Management Protocols.

International journal of general medicine
2025

Procedural success and safety of a standardized less invasive surfactant administration protocol using fentanyl premedication and video laryngoscopy in preterm infants <32 weeks' gestation.

Frontiers in pediatrics
2025

Comparative study of synthetic and natural-source pulmonary surfactants in the treatment of neonatal respiratory distress syndrome in very low birth weight neonates.

Pakistan journal of pharmaceutical sciences
2026

Congenital measles: A case highlighting challenges in clinical interventions in a developing country.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
2025

Perinatal and maternal outcomes of extremely early-onset fetal growth restriction (≤ 26 weeks): systematic review and meta-analysis.

Ultrasound in obstetrics &amp; gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
2025

Decreased Glucocorticoid Receptor Expression and Function in Cord Blood Immune Cells from Preterm Neonates with Morbidity.

International journal of molecular sciences
2025

Lung Ultrasound in Pediatrics: A Review with Core Principles That Every User Should Know.

Diagnostics (Basel, Switzerland)
2025

Congenital brucellosis in a newborn: A rare case report and clinical insights.

The Journal of international medical research
2025

Post Extubation Noninvasive Respiratory Support for Pediatric ARDS.

Pediatric pulmonology
2025

Adding Early Postnatal Parameters of Ventilation to Prognostic Models for Pulmonary Outcome in Very Preterm Infants.

Pediatric pulmonology
2025

Prediction of preeclampsia-related outcomes with the sFlt-1 (soluble Fms-like tyrosine kinase-1)/PlGF (placental growth factor)-ratio in the routine in twin pregnancies.

Pregnancy hypertension
2025

Indications and timings for caffeine initiation in preterm infants.

The Cochrane database of systematic reviews
2025

The influence of early nutrition intake and clinical factors on the brain development of preterm infants with intrauterine growth restriction.

Translational pediatrics
2025

Comparison of two fractions of inspired oxygen thresholds (0.25 vs 0.30) for surfactant administration in very preterm infants with respiratory distress syndrome under nasal intermittent positive pressure ventilation: study protocol for a multicentre randomised controlled, superiority trial.

BMJ paediatrics open
2025

Maternal and neonatal outcomes in primary vs. secondary meconium-stained amniotic fluid.

Taiwanese journal of obstetrics &amp; gynecology
2025

Risk factors for mortality in neonatal ARDS: a multicenter retrospective cohort study in China.

Frontiers of medicine
2025

Lung ultrasound for predicting surfactant administration in ventilated and non-ventilated infants with respiratory distress syndrome: a multicenter prospective study.

European journal of pediatrics
2025

The delivery modes and morbidity/mortality in very preterm infants with birth weight <1,500 g: a retrospective cohort study.

Frontiers in public health
2025

Case Report: Pulmonary color Doppler ultrasonography features of congenital tuberculosis in a preterm infant.

Frontiers in pediatrics
2025

Impact of the COVID-19 pandemic on morbidity and mortality in a Spanish cohort of very-preterm/very-low-birth weight newborns.

Pediatrics and neonatology
2025

Novel Airway Challenges in DEGCAGS Syndrome: Managing Infant Laryngeal Hamartomas.

The American journal of case reports
2025

Antenatal corticosteroids in diabetic pregnancies and outcomes of very preterm infants: a national multicenter cohort study.

European journal of pediatrics
2025

A Unique Case of Beard-Distributed Infantile Hemangioma With Subglottic Extension and Evaluation for PHACE Syndrome.

Ear, nose, &amp; throat journal
2026

Duration of noninvasive respiratory support in preterm infants: Association with gestational age and risk factors for delayed weaning.

Journal of perinatology : official journal of the California Perinatal Association
2026

Antenatal Corticosteroids and Neonatal Outcomes Among Patients With Twin Gestations at Risk for Late Preterm Birth.

Obstetrics and gynecology
2025

Lung ultrasound aeration scores and their utility in predicting success of weaning off respiratory support in preterm neonates-A prospective cohort study.

European journal of pediatrics
2025

Association of maternal pre-pregnancy body mass index with neonatal respiratory outcomes: a nationwide population-based cohort study.

Scientific reports
2025

Interpretable machine learning model for predicting low birth weight in singleton pregnancies: a retrospective cohort study.

BMC pregnancy and childbirth
2025

Case Report: Hydroxychloroquine in an infant with NKX2-1-associated interstitial lung disease.

Frontiers in pediatrics
2025

Vibrating mesh nebulizers vs. less invasive surfactant administration in the treatment of preterm respiratory distress syndrome: a multicenter, open-label, exploratory, randomized clinical trial.

European journal of medical research
2025

Lung ultrasound imaging can effectively monitor and guide treatment with pulmonary surfactant for preterm infants of pulmonary consolidation: a prospective observational cohort study.

Frontiers in pediatrics
2025

Risk factors for adverse neonatal outcomes among pregnant women with an abnormal 50-g glucose challenge test without gestational diabetes mellitus.

The journal of maternal-fetal &amp; neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
2025

Lemierre-like syndrome and severe descending mediastinitis in an Infant with retropharyngeal abscess due to methicillin susceptible Staphylococcus aureus.

IDCases
2025

The Relationship Between Refeeding Syndrome and Preterm Morbidities in Preterm Infants.

Children (Basel, Switzerland)
2025

Comparison of Clinical Outcomes Between Calfactant and Poractant-Alfa in Preterm Infants with Respiratory Distress Syndrome.

Children (Basel, Switzerland)
2025

Life-Threatening Noninfectious Complications of Peritoneal Dialysis in an Infant with End-Stage Kidney Disease.

Pediatric reports
2025

Impact of Prepregnancy Maternal Fasting Glucose Levels on Pregnancy and Neonatal Morbidity in Women With Pregestational Diabetes Mellitus.

Journal of Korean medical science
2025

Effect of delayed cord clamping on the risk of bronchopulmonary dysplasia in preterm infants with respiratory distress.

BMC pediatrics
2025

A novel ASXL3 gene variant in a Chinese Boy causing Bainbridge.

BMC infectious diseases
2025

Effectiveness of the Information-Motivation-Behavioral Skills Model-Based Nursing Intervention on Maternal and Neonatal Outcomes in Women with Gestational Diabetes Mellitus: A Randomized Controlled Trial.

Women's health reports (New Rochelle, N.Y.)
2025

Retrospective cohort study on the correlation between serum 25(OH)D, vitamin A and neonatal respiratory distress syndrome (NRDS) in premature infants.

Translational pediatrics
2025

Multidisciplinary Management of Severe Maternal H1N1 Infection With Acute Respiratory Distress Syndrome and Ventilator-Associated Pneumonia Requiring Extracorporeal Membrane Oxygenation: A Case Report.

Cureus

Associações

Organizações que acompanham esta doença — pra ter apoio e orientação

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Comunidades

Grupos ativos de quem convive com esta doença aqui no Raras

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Doenças relacionadas

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Prognostic significance of serum apelin-13 and galectin-3 concentrations as potential indicators of severity and mortality in pediatric acute respiratory distress syndrome.
    The Turkish journal of pediatrics· 2026· PMID 41871558mais citado
  2. Time to initiate trophic feeding and predictors among preterm neonates admitted at General Hospitals in Tigray, 2025.
    PloS one· 2026· PMID 41871109mais citado
  3. Neonatal hypoxic-ischemic encephalopathy online registry in Shenzhen: protocol for a multicentre, prospective, open, observational cohort study.
    BMJ open· 2026· PMID 41857827mais citado
  4. High-Frequency Oscillation vs Mechanical Ventilation for Neonatal Acute Respiratory Distress Syndrome: A Randomized Clinical Trial.
    JAMA network open· 2026· PMID 41801204mais citado
  5. Drying Very Preterm Infants Before Plastic Wrapping at Birth: A Randomized Clinical Trial.
    JAMA network open· 2026· PMID 41774445mais citado
  6. Elevated Driving Pressure in Pressure-Controlled Ventilation: An Independent Risk Factor for Adverse Outcomes in Mechanically Ventilated Neonates.
    Lung· 2026· PMID 41848933recente
  7. Prevention of Pressure Injuries During Nasal Continuous Positive Airway Pressure in Newborns: A Non-pharmacological Intervention Trial.
    Nurs Crit Care· 2026· PMID 41846515recente
  8. Efficacy evaluation of pulmonary surfactant guided by lung ultrasound score in neonatal respiratory distress syndrome: a prospective observational study in Ganzi Tibetan Autonomous Prefecture.
    J Trop Pediatr· 2026· PMID 41770898recente
  9. Impact of timing from last dose of dexamethasone administration to delivery, different steroid courses, and fetal number on preterm neonatal outcomes.
    PLoS One· 2026· PMID 41770776recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:70587(Orphanet)
  2. OMIM OMIM:267450(OMIM)
  3. MONDO:0009971(MONDO)
  4. GARD:112(GARD (NIH))
  5. Busca completa no PubMed(PubMed)
  6. Artigo Wikipedia(Wikipedia)
  7. Q754348(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Síndrome de dificuldade respiratória aguda do lactente
Compêndio · Raras BR

Síndrome de dificuldade respiratória aguda do lactente

ORPHA:70587 · MONDO:0009971
CID-10
P22.0 · Síndrome da angústia respiratória do recém-nascido
CID-11
MedGen
UMLS
C0020192
Wikidata
Wikipedia
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