É uma condição de dano pulmonar que se caracteriza pelo acúmulo de líquido nos dois pulmões (edema pulmonar), o qual é rico em neutrófilos (um tipo de célula de defesa). Isso ocorre na ausência de problemas cardíacos graves (insuficiência cardíaca). Pode apresentar diferentes tipos de lesões nos pulmões, tanto no revestimento dos vasos sanguíneos (endotelial) quanto nas células que revestem as vias respiratórias (epitelial), devido a diversos fatores (físicos, químicos ou biológicos).
Introdução
O que você precisa saber de cara
É uma condição de dano pulmonar que se caracteriza pelo acúmulo de líquido nos dois pulmões (edema pulmonar), o qual é rico em neutrófilos (um tipo de célula de defesa). Isso ocorre na ausência de problemas cardíacos graves (insuficiência cardíaca). Pode apresentar diferentes tipos de lesões nos pulmões, tanto no revestimento dos vasos sanguíneos (endotelial) quanto nas células que revestem as vias respiratórias (epitelial), devido a diversos fatores (físicos, químicos ou biológicos).
Escala de raridade
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Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 11.210
C3 as a sensitive biomarker of alveolocapillary barrier integrity in acute lung injury: Protective modulation by enoxaparin.
Enoxaparin (ENX), a low-molecular-weight heparin (LMWH) widely used for venous thromboembolism prophylaxis, has been reported to inhibit complement activation at proximal steps. Early complement activation is increasingly recognized as a key driver of alveolocapillary barrier disruption, highlighting the need for early biomarkers and prophylactic strategies in ALI. Accordingly, this study investigated local and systemic effects of ENX on C2, C3, TNF-α, and IL-8 in an LPS-induced ALI model to clarify the contribution of complement blockade to inflammatory pathogenesis. Forty-six male Wistar albino rats were randomized in four groups (SHM, ENX, LPS, and ENX+LPS) and treated with intratracheal LPS (5 mg/kg) followed by subcutaneous ENX (2 mg/kg). After six hours, BALF, serum, and lung tissues were collected. Biomarkers were quantified by ELISA; histopathological changes were evaluated using staining (H-E, MT, PAS), and immunohistochemistry for TNF-α and CC16. LPS reduced serum C3, increased BALF TNF-α, enhanced TNF-α immunoreactivity, and disrupted the alveolocapillary barrier, reflected by elevated Smith and ATS scores. ENX mitigated these alterations, preserved barrier integrity, and restricted inflammation predominantly to the interstitium. Strong correlations between C3 levels and histopathological scores underscored its central role of C3 in the progression of ALI. Conversely, C2 showed limited variation and no correlation with tissue injury. CC16 expression was reduced following LPS exposure, indicating club cell dysfunction and interstitial inflammation, with only partial recovery under ENX. Collectively, these findings identify C3 as a sensitive early biomarker of complement-driven lung injury and support early complement modulation as a promising prophylactic approach in ALI.
Efficacy of heparin in respiratory support of near-term rabbits with meconium-induced acute lung injury: Linear regression model analyses.
To explore the pharmacotherapeutic efficacy of heparin in the management of meconium-induced acute lung injury (ALI) in near-term newborn rabbits subjected to mechanical ventilation (MV) and ancillary respiratory medications. Newborn rabbits at 30-day gestation (term 31 days) were anesthetized, intratracheally intubated and received human meconium-saline suspension, followed by parallel MV with individually adjusted tidal volume in a multi-plethysmograph-ventilator system. When ALI was induced after initial 3-h MV, therapeutic effects of single or combined subcutaneous heparin (100 U/kg), surfactant (200 mg/kg), and inhaled nitric oxide (iNO, 10 ppm), were compared for lung protective ventilation and survival as outcome, analyzed with linear regression models. Significantly reduced respiratory compliance by meconium was reinstalled during ensuing 7-h MV, with improved survival, among the treatment groups. The impact was verified by lung injury severity, surfactant phospholipid pools, and multiple mRNA expressions of surfactant proteins, lung fluid clearance-related factors, inflammatory mediators, growth factors, endothelial cell injury and coagulation-related factors as subphenotyping biomarkers. The overall benefits of heparin alone, or exerted with the dual and triple regimens, were discernible by both generalized linear model and Cox proportional hazard ratio regression for survival and other major variables as outcome. Its adverse effects were intangible. The comparable efficacy of heparin, alongside the PS and NO, was corroborated in attenuating meconium-mediated, ventilator-induced ALI, which should warrant clinical investigation to validate.
Endogenous "Time Bomb" - Mislocalized Phospholipase A2 as a Critical Mediator of Ultra-Rapid Mortality in Sepsis and Acute Lung Injury.
This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically within the alveolar environment to induce rapid, "electric shock-like" lethality, akin to chemical toxins, while also exhibiting extreme toxicity comparable to that of biological toxins, and functioning as a potential "time bomb" in the body. When exacerbated inflammation impairs the pulmonary barrier, PLA2 from the circulation can penetrate into the lungs. Once activated in the alveolar space, it rapidly hydrolyzes pulmonary surfactant phospholipids, causing a drastic decline in surface tension (>30%). This leads to alveolar overdistension, instantaneous respiratory failure, and asphyxiation-an acute mortality effect strikingly similar to that observed in sepsis and severe pulmonary diseases. PLA2 penetration and lethality are more pronounced in aged animals. Based on these findings, a combination therapy comprising phospholipase (dioleoylphosphatidylserine) and an inhibitor (varespladib) was developed, which significantly improved survival rates from 0% to over 90% in mice with sepsis, acute lung injury, and PLA2 poisoning. This study provides critical theoretical foundations and intervention strategies for the clinical treatment of related diseases.
Prognostic significance of serum apelin-13 and galectin-3 concentrations as potential indicators of severity and mortality in pediatric acute respiratory distress syndrome.
The predictive and prognostic significance of apelin and galectin-3 as biomarkers in pediatric acute respiratory distress syndrome (PARDS) and lung injury has remained limited. This study examined the association between serum apelin-13 and galectin-3 levels, PARDS severity, and patient outcomes. The study included children aged 1 month to 18 years diagnosed with PARDS on admission to a pediatric intensive care unit, alongside age- and sex-matched outpatient controls. PARDS was diagnosed and classified by severity according to Second Pediatric Acute Lung Injury Consensus Conference (PALICC-2) guidelines, based on oxygenation indices for non-invasive and invasive ventilation. Exclusion criteria included prior transplants, chronic lung disease, cyanotic congenital heart disease, prolonged ventilation, and other major conditions. After informed parental consent, 3 mL of peripheral venous blood was collected from all participants. Serum samples for apelin-13 and galectin-3 were stored at -80°C and analyzed using commercial enzyme-linked immunosorbent assay (ELISA) kits. Demographic, clinical, and laboratory data were systematically recorded for analysis. The study and control groups were comparable in age and gender. Patients had significantly lower hemoglobin, hematocrit, red blood cell, calcium, and phosphorus levels, and higher neutrophil counts, C-reactive protein, and liver enzymes. Apelin-13 levels did not differ significantly between groups, wheras median galectin-3 levels were significantly higher in patients (p=0.003). Apelin-13 levels were significantly lower and galectin-3 levels significantly higher with increasing PARDS severity. Severe PARDS was associated with lower PaO2/FiO2 ratios, arterial pH, and higher ventilator pressures. Mortality was 36.4% in severe and 22.7% in moderate PARDS. Serum galectin-3 level was the sole independent predictor of mortality (OR: 1.20, 95% CI 1.02-1.39, p=0.02). Although the apelin/APJ system's role in acute lung injury is known, its diagnostic and prognostic value in PARDS requires further study. Galectin-3 levels correlate with disease severity and outcomes, highlighting the need for larger, age- and phenotype-homogenized studies to confirm its role as an independent mortality predictor.
Aerosolized adenoviral IL4/IL10 delivery alleviates LPS-induced acute lung injury.
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are severe inflammatory lung diseases with high morbidity and mortality, lacking specific treatments. Inhalation offers direct access to the damaged lung epithelium, making tracheal gene delivery a promising approach. However, challenges such as low efficiency, off-target effects, and repeated dosing limit its effectiveness. In this study, we developed an inhalable recombinant adenoviral vector (Ad-IL4/10) carrying dual reporter genes to deliver interleukin-10 (IL10) and interleukin-4 (IL4) to the lungs, enabling efficient and sustained expression of anti-inflammatory cytokines. Using a lipopolysaccharide (LPS)-induced lung injury mouse model, the anti-inflammatory effects of aerosolized Ad-IL4/10 were evaluated. The results showed that aerosolized Ad-IL4/10 significantly reduced weight loss, lung wet-to-dry weight ratio, and total protein levels in bronchoalveolar lavage fluid (BALF). Additionally, it alleviated pulmonary inflammation and alveolar damage while suppressing proinflammatory markers and LPS-induced monocyte and neutrophil infiltration. Ad-IL4/10 also restored monocyte-macrophage homeostasis. These findings indicate that an inhalable adenoviral vector effectively mitigates LPS-induced lung injury through IL4 and IL10 delivery, offering a promising therapeutic strategy for ALI.
Publicações recentes
Kindlins in the cardiovascular system: from development to pathogenesis.
Attenuation of cGAS-STING signaling-mediated lung inflammation during infection through autophagy induction by bioactive nanodevices.
Atractylenolide II alleviates LPS-induced acute lung injury in A549 cells via the TNIP2/NF-κB pathway.
Transcriptomics and network pharmacology reveal that baicalin alleviates acute lung injury induced by H1N1 via targeting STAT1.
📖 RevisãoFecal microbiota transplantation alleviates sepsis-induced acute lung injury by improving mitochondrial function.
📚 EuropePMC10.665 artigos no totalmostrando 196
Harmine Derivatives Alleviate LPS-Induced Acute Lung Injury via Targeting GSK3β.
InflammationEphA2 monoclonal antibody attenuates hyperoxia-induced acute lung injury by preserving the alveolar-endothelial barrier.
Scientific reports[Akt/SIRT3-dependent mitochondrial autophagy inhibits apoptosis of alveolar epithelial cells and alleviates hyperoxia-induced acute lung injury].
Zhonghua wei zhong bing ji jiu yi xueImmune-epithelial dual-targeting bilirubin nanoparticles for acute lung injury.
Journal of controlled release : official journal of the Controlled Release SocietyModulation of the gut-lung axis by probiotic VSL#3 alleviates acute lung injury via restricting NETosis in sepsis.
Biochemical and biophysical research communicationsC3 as a sensitive biomarker of alveolocapillary barrier integrity in acute lung injury: Protective modulation by enoxaparin.
Tissue & cellEfficacy of heparin in respiratory support of near-term rabbits with meconium-induced acute lung injury: Linear regression model analyses.
PloS oneEfficiency of Alveolar Ventilation During High-Frequency Modes in Piglets: Effects of Airway and Tissue Heterogeneity.
Anesthesia and analgesiaEndogenous "Time Bomb" - Mislocalized Phospholipase A2 as a Critical Mediator of Ultra-Rapid Mortality in Sepsis and Acute Lung Injury.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)Cytokine-driven PANoptosis of alveolar macrophages mediated by STAT1 underlies acute lung injury in hypervirulent Klebsiella pneumoniae infection.
mBioEngineering Resatorvid-Loaded Sub-Microgels of Epigallocatechin-3-gallate/Hyaluronic Acid to Treat Acute Lung Injury.
Advanced healthcare materialsEffect of reticulocalbin 3 on monocyte-to-macrophage differentiation in sepsis through modulating autophagy.
Chinese medical journalAutoantibodies induced by Mycoplasma pneumoniae infection underlie the severity of acute lung injury in children.
Mucosal immunologyPrognostic significance of serum apelin-13 and galectin-3 concentrations as potential indicators of severity and mortality in pediatric acute respiratory distress syndrome.
The Turkish journal of pediatricsPlant-derived bioactive compounds attenuate acute lung injury by regulating cellular autophagy and inflammation: A review.
International immunopharmacologyThe CXCR2-XBP1-NF-κB Axis Drives Inflammatory Amplification and Tissue Damage in Acute Lung Injury.
InflammationLung-Selective Immune Reprogramming via In Situ Red Blood Cell Hitchhiking Nanoparticles.
bioRxiv : the preprint server for biologySerum Hepcidin Levels are Associated with Poor Outcomes of Patients with Severe Traumatic Brain Injury: A Two-Center Observational Analytical Study.
International journal of general medicineGinsenoside Rg3 Mitigates LPS-Induced Injury in Human Bronchial Epithelial Cells by Restoring Autophagic Flux and Inhibiting the TLR4/NF-κB-Mediated Inflammatory Response.
Journal of inflammation researchPredicting mortality with machine learning & biomarkers: A cohort analysis from aerosolized β₂-agonist for treatment of acute lung injury (ALTA) trial.
Physiological reportsNano-sized DNase scavenges cell-free DNA for acute lung injury treatment.
Journal of controlled release : official journal of the Controlled Release SocietyPhenylephrine attenuates LPS-induced lung injury via Foxh1/GSK-3β/β-catenin-mediated alveolar epithelial cell differentiation in ARDS.
International immunopharmacologyA novel mechanism for treating acute lung injury with ligustilide: elucidation via network pharmacology and in vitro validation.
Journal of natural medicinesCombined use of erythropoiesis-stimulating agents and transfusion guidelines in NICU infants.
Seminars in fetal & neonatal medicineFrom canes to pills: the evolution of carbon monoxide therapeutics.
Advanced drug delivery reviewsAerosolized adenoviral IL4/IL10 delivery alleviates LPS-induced acute lung injury.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical SciencesBiomarkers in Traumatic Lung Injury - A Systematic Review.
The Journal of surgical researchCurculigoside attenuates influenza virus-induced acute lung injury by modulating the Keap1/Nrf2 signaling pathway.
Naunyn-Schmiedeberg's archives of pharmacologyMeis1-driven suppression of MIF/CD74 signaling promotes M2 macrophage polarization and protects against inflammatory damage in experimental acute lung injury.
Cell biology and toxicologyPreformed HNA-3a antibodies in renal transplantation: A suggested approach to risk assessment.
Transplant immunologyAtmospheric particulate matter impairs pulmonary barriers by triggering FTH1-mediated ferroptosis.
iScienceQingjin Pingchuan formula attenuates pulmonary inflammation by reprogramming neutrophil SHP1-JAK2/SRC-STAT3 signaling.
Phytomedicine : international journal of phytotherapy and phytopharmacologyMicroencapsulated Akkermansia muciniphila alleviates acute lung injury in juvenile mice by protecting intestinal barrier.
Frontiers in cellular and infection microbiologyMavacamten Derivatives Significantly Ameliorate Lipopolysaccharide-Induced Acute Lung Injury, Partly by Modulating Nuclear Factor Kappa‑B Signaling.
ACS pharmacology & translational scienceParabacteroides goldsteinii-derived outer membrane vesicles alleviate acute lung injury via modulation of bile acid metabolism.
Journal of nanobiotechnologyDownregulation of Pannexin-1 attenuates sepsis-induced acute lung injury via activation of the cAMP/PKA pathway.
The international journal of biochemistry & cell biologySpore-inspired surface engineering enhances macrophage phagocytosis for inhalation therapy of acute lung injury.
Journal of controlled release : official journal of the Controlled Release SocietyComparative toxicity of menthol- and tobacco-flavored electronic cigarette constituents inducing inflammation, epithelial barrier dysfunction, and nicotinic acetylcholine receptor modulation in the absence of nicotine.
Toxicology reportsMacrophage reprogramming and functional plasticity in sepsis.
Frontiers in immunologyBlood Substitutes Used in Dentistry and OMFS: Systematic Review.
Journal of pharmacy & bioallied sciencesTriphenylphosphine bromide enhances the effect of nano-micellar drug delivery system loaded with ROS inhibitor TEMPO on acute lung injury.
Journal of biological engineering'Tripod-like' lung-targeting (LuT) lipids for highly efficient and selective LNPs for gene delivery and editing.
Nature biomedical engineeringKnowledge, attitudes, and practices regarding transfusion-related acute lung injury among healthcare providers in Jiangsu: a multicenter cross-sectional study.
Scientific reportsFebrile transfusion-associated circulatory overload in adult oncology patients.
Vox sanguinisDesign and synthesis of novel sEH inhibitors for the treatment of acute lung injury.
European journal of medicinal chemistryUnravelling the potential of Vitex negundo leaf extract in LPS-induced acute lung injury in mice through modulation of the TLR-4/NF-κB p65/iNOS pathway: Insights from integrated phytochemical characterization, in silico, and in vivo analysis.
Tissue & cellEvaluation of Supracardiac Atherosclerosis in Stroke with a Noncontrast Head-Neck-Aortic Vessel Wall MRI.
RadiologyHigh-Flow or Standard Oxygen in Acute Hypoxemic Respiratory Failure.
The New England journal of medicineThe Role of Duffy Antigen Receptor for Chemokines in Acute Respiratory Distress Syndrome.
Journal of leukocyte biologyLysine attenuates acute lung injury by restoring α-tubulin acetylation and ciliary activity.
Cell death discoveryExosomal Rspondin3 serves as a master regulator of immunometabolic repair in sepsis: synergistic activation of macrophage M2 polarization and endothelial BMP10 signaling.
International immunopharmacologyLCN2 aggravates sepsis-induced ALI by inhibiting MUC1 to activate ER-stress-autophagy induced ferroptosis via lactate/MCT1/AMPK/mTOR axis.
Apoptosis : an international journal on programmed cell deathThe bug, the burden, and the biology: beyond host-centric phenotyping in sepsis.
The Journal of clinical investigationInhaled bovine lactoferrin modulates the p47phox-MPO-NETosis axis in acute lung injury: implications for bioengineered nanomedicine in respiratory infections.
Frontiers in immunologyUnbiased characterization of COVID-19 endotypes leads to prognostication of high-risk individuals using routine blood tests.
Communications medicineASIC1a promotes alveolar epithelial apoptosis and acute lung injury through repression of the LncRNA00178/miR-466b-3p/Gucy1b1 ceRNA network.
International immunopharmacologyIntegrated Multi-Omics Analysis Reveals Modulation of the Ras Pathway by Siji Kangbingdu Mixture in Acute Lung Injury.
Combinatorial chemistry & high throughput screeningTelomere damage-mediated senescence in alveolar epithelial type II cells but not in macrophages aggravates inflammation in acute lung injury.
Respiratory researchBiomimetic zwitterionic micelles for efficient mucus penetration and pulmonary targeting in acute lung injury.
Acta biomaterialiaPost-Acute Sequelae of COVID-19 Persist Over 3 Years in Acute Lung Injury/Acute Respiratory Distress Syndrome Survivors But Are Not Associated With Persistent Thromboinflammation or Endothelial Dysfunction.
Critical care explorationsVascular Endothelial Growth Factor-D Improves Lung Vascular Integrity During Acute Lung Injury.
Circulation researchUSP19 alleviates LPS-induced acute lung injury via inhibiting TAK1 activation.
Biology directMegakaryocyte and platelet thrombospondin-1 regulates matrix remodeling by stabilizing basement membrane COL6A1 in lung injury.
Nature communicationsFNDC4 modulates macrophage responses and suppresses NF-κB in sepsis-induced lung injury.
Molecular immunologyMinimolide F alleviates inflammatory diseases by specifically targeting STING and blocking IRF3 recruitment.
International immunopharmacologyProtective Effects of Gallic Acid in LPS-Induced Lung Injury via Modulation of Oxidative Stress: AKT1/NRF2 and IL-10 Signaling.
Journal of biochemical and molecular toxicologyInhibition of macrophage pyroptosis protects against sepsis-induced injury to the alveolar epithelial barrier.
Journal of thoracic diseaseIntra- and extrapulmonary lipopolysaccharides-induced acute lung injury and pharmacotherapeutic response patterns in ventilated 7-day-old rabbits.
Experimental biology and medicine (Maywood, N.J.)Terminalia chebula Extract Alleviates Lipopolysaccharide-Induced Acute Lung Injury by Modulating the Interleukin-17-Dependent Mitogen-Activated Protein Kinase/Nuclear Factor-Kappa B Signaling Pathways.
Phytotherapy research : PTR[Baicalin ameliorates obesity-related lung injury by targeting FSTL1/DIP2A signaling pathway].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medicaOrthogonal NIR/Ratiometric Probe for Simultaneous Imaging of NO and ATP in Acute Lung Injury: Elucidating Metabolic Dysregulation and Therapeutic Screening.
Analytical chemistryMechanistic insights into mitigation of sepsis-induced acute lung injury by quercitrin via TLR4/MAPK pathway inhibition.
The Journal of pharmacy and pharmacologyNear infrared enhanced palladium loaded siraitia grosvenorii carbon dots amplify mitophagy for acute lung injury immunotherapy.
Bioactive materialsTargeted inhibition of PARP-1 in pulmonary epithelial cells and macrophages via SPA-functionalized microparticles attenuates sepsis-induced lung injury.
Materials today. BioTetrastigma hemsleyanum Diels et Gilg Flavonoids Against Acute Lung Injury Via Block NLRP3 Inflammation.
Mediators of inflammationAdverse events associated with use of immunoglobulin in pediatric patients reported to the US Food and Drug Administration Adverse Event Reporting System, 2001-2023.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and ImmunologyGinsenoside Rg1 mitigates sepsis-associated acute respiratory distress syndrome by promoting autophagy through the Prdx1-PTEN/PI3K/AKT pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacologyNicotinamide N-oxide alleviates sepsis-induced acute lung injury by inhibiting ferroptosis through activation of the SIRT1/AKT signalling pathway.
Pulmonary pharmacology & therapeuticsPhenolic fraction of Elsholtzia penduliflora W.W.Sm. ameliorates influenza A virus-induced acute lung injury by inhibiting the IDO-1-mitochondria-STAT1 signaling axis.
Journal of ethnopharmacologyTherapeutic Effects Assessment in Acute Lung Injury Using Hyperpolarized 129Xe Magnetic Resonance.
NMR in biomedicineRANKL Attenuates Sepsis-Associated Acute Lung Injury Through the OPG/RANKL/RANK/TLR4 Pathway.
Immunity, inflammation and diseaseCircular RNAs in sepsis-induced acute lung injury: emerging mechanisms and therapeutic potential.
Frontiers in immunologyImpact of optic nerve sheath diameter variations on respiratory mechanics in ventilated traumatic brain injury patients: A pilot prospective observational study.
Indian journal of anaesthesiaPerfluorocarbon ameliorates high-altitude pulmonary edema and blood-gas barrier dysfunction in a canine model and a lung-on-chip model by suppressing the HIF-1α/HO-1 pathway.
European journal of pharmacologyERG-lacking endothelium identifies IL8-CXCR2 axis as a therapeutic target for resolving neutrophilic lung vascular injury.
JCI insightHyaluronic acid engineered melanin-MOF nanoreactor synergistically remodeling redox and immune homeostasis for targeted acute lung injury therapy.
Materials today. BioPolymyxin B-antioxidant nanoassemblies mitigate nephrotoxicity and attenuate sepsis-induced acute lung injury.
Journal of controlled release : official journal of the Controlled Release SocietyMechanism of CircBbs9 in Lung Epithelial Cell Ferroptosis in Lipopolysaccharide-Induced Acute Lung Injury.
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyContrast-Related Acute Pulmonary Edema Following Diagnostic Coronary Angiography: A Case Report.
CureusLncRNA NORAD Enhances Inflammatory Injury in Sepsis-Associated Acute Lung Damage Through miR-150-5p/STAT1-Dependent NF-κB Activation.
The Kaohsiung journal of medical sciencesDiscovery of Peripherally Restricted Indazole-Based Phosphodiesterase 4B Inhibitors Targeting the C-terminal Regulatory Helix for Treating Acute Lung Injury.
Journal of medicinal chemistryKCNJ2-AS1 Drives Inflammation and Ferroptosis via the miR-212-3p/EGR1 Axis in Sepsis-Associated Acute Lung Injury.
Journal of biochemical and molecular toxicologyPlasma Biomarkers of Brain Injury in Critically Ill Children Receiving Extracorporeal Membrane Oxygenation.
JAMA pediatricsPolydatin in respiratory diseases: multi-target mechanisms and therapeutic potential.
Frontiers in pharmacologyMolecular and Cellular Mechanisms Underlying the Therapeutic Effects of Genistein in Sepsis: A Systematic Review.
Journal of biochemical and molecular toxicologyAssociation between ventilatory ratio and subsequent development of severe late acute kidney injury in acute respiratory distress syndrome.
Medicina intensivaAlveolar epithelial NF-κB/RelA guards the lung against bacterial infection.
Journal of immunology (Baltimore, Md. : 1950)PFKFB3-driven glycolysis in endothelial cells activates RhoA/ROCK1 to promote pulmonary vascular leakage in heatstroke.
Biochimica et biophysica acta. Molecular basis of diseaseThe combination of paeoniflorin and hydroxysafflor yellow A alleviated pulmonary thrombosis by inhibiting platelet-neutrophil interaction via the P-selectin-PSGL-1 signaling axis.
Phytomedicine : international journal of phytotherapy and phytopharmacologyDysregulated Copper Metabolism-Induced Cuproptosis Contributes to Mitochondrial Dysfunction and Macrophage Inflammatory Response in Acute Lung Injury.
Antioxidants & redox signalingAssessing the real-world drug safety of sevelamer for hyperphosphatemia: Insights from a comprehensive analysis of the FDA adverse event reporting system (FAERS) database.
MedicineTargeting the Keap1-Nrf2/GPX4 axis to suppress ferroptosis in acute lung injury.
Free radical biology & medicineProtective effects of harringtonine on lipopolysaccharide-induced acute lung injury via a novel intratracheal instillation method.
International immunopharmacologyEngineering Polymer-Lipid Integrated Nanoparticles with Quantitative Design Principles for Organ-Selective mRNA Delivery.
Journal of the American Chemical SocietyFcer1g and St3gal1: Macrophage-associated angiogenesis biomarkers and therapeutic targets in sepsis-induced acute lung injury.
PloS oneMicrobial metabolite oxindole curbs acute lung injury by suppressing CXCL13.
Proceedings of the National Academy of Sciences of the United States of AmericaKidney-Lung Crosstalk in Acute Nephrologic Involvement: Mechanisms, Complement Activation, and Implications for Multiorgan Dysfunction.
Life (Basel, Switzerland)NETosis-Dependent Generation of Immunodeficient Low-Density Neutrophils Exacerbates Sepsis-Induced Acute Lung Injury.
International journal of molecular sciencesDietary Cannabis Seed Supplementation Attenuates Inflammation and Pancreatic Injury in a Cerulein-Induced Acute Pancreatitis Mouse Model.
Current issues in molecular biologyExploring the Effects and Mechanisms of Neohesperidin Dihydrochalcone on Acute Lung Injury in Mice with Sepsis Using Network Pharmacology and Machine Learning.
Current issues in molecular biologyOral and Intranasal Administration of Polydeoxyribonucleotide Isolated from Porphyra sp. Ameliorates Acute Lung Injury via Suppressing Proinflammatory Cytokine Production in Mice.
Current issues in molecular biologyExtracellular Superoxide Dismutase in Acute Respiratory Distress Syndrome: Pathogenic Mechanisms and Therapeutic Implications.
Antioxidants (Basel, Switzerland)NEC-Associated Bronchopulmonary Dysplasia and the Gut-Lung Axis in Preterm Infants.
American journal of perinatologyPlatycodin D3 protects against sepsis-associated acute lung injury through direct inhibition of the PKM2-NLRP3 axis.
Cellular signallingThe NLRP3 inhibitor, MCC950, attenuates environmental pollutant PM2.5-induced acute lung injury by inhibiting alveolar macrophage pyroptosis.
Current research in toxicologymiRNA-149-5p protects endothelial function and attenuates sepsis-induced acute lung injury by targeting ABCA1.
International immunopharmacologyFurin Inhibition Protects Against Acute Lung Injury in a Mouse Model of Pseudomonas Aeruginosa Infection.
American journal of respiratory cell and molecular biologyATP6V0C-HIF-1α reciprocal activation drives acute lung injury.
American journal of respiratory cell and molecular biologyC-Type Lectin-Like Receptor 2 in Lung Epithelium Protects Against Acute Lung Injury.
American journal of respiratory cell and molecular biologyPulmonary atelectasis in anaesthesia and critical care.
BJA education1-Nitropyrene induces acute lung injury via SYVN1/Caspase-11-mediated apoptosis and pyroptosis in pulmonary epithelial cells.
Frontiers in pharmacologyNovel Carbon Dots Nanomaterials for the Precision Diagnosis and Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome: Mechanisms and Applications.
International journal of nanomedicineN6-methyladenosine methylation in acute lung injury: Mechanisms and research progress.
Journal of intensive medicineRole of ITIH4 in Modulating YAP/TAZ-Mediated Apoptosis of Type II Alveolar Epithelium during Acute Respiratory Distress Syndrome.
Pharmaceutical researchRole of ferroptosis and autophagy in pulmonary diseases.
Tissue & cellLactate regulation in high-altitude hypoxic adaptation attenuates LPS-Induced acute lung injury: links to glucose metabolism and anti-inflammatory therapeutic potential.
Critical care (London, England)FTY-720 pre-treatment attenuates acute lung injury following bilateral renal ischemia/reperfusion but not bilateral nephrectomy.
Scientific reportsDiscovery of 6l with a New Skeleton of 6-Oxo-N-(4-(Quinolin-4-yloxy)phenyl)-1,6-dihydropyridine-3-carboxamide as a Dual-Action Inhibitor against JNK2 and the MKK7-JNK2 Protein-Protein Interaction for Acute Lung Injury.
Journal of medicinal chemistryAgmatine suppresses the imidazoline I2 receptor/ribosomal S6 kinase 2/NF-κB signaling pathway regulating alveolar macrophage polarization and ameliorating sepsis-associated acute lung injury.
International journal of immunopathology and pharmacologyModified Dachengqi Decoction ameliorates sepsis-induced lung injury via the gut microbiota-bile acid axis.
Frontiers in cellular and infection microbiologyOvercoming immune resistance in ovarian cancer: checkpoint inhibitors, tumor microenvironment, and translational advances.
Frontiers in oncologyFarrerol mitigates lipopolysaccharide-induced acute lung injury through dual regulation of oxidative stress and inflammation via Nrf2 pathway.
Open life sciencesThe relationship between serum levels of miR-342 and miR-148a and acute lung injury in sepsis patients.
Open medicine (Warsaw, Poland)Monocyte-Derived Alveolar Macrophages in ALI/ARDS: The Core Drivers of Inflammation.
ImmunologyCannabidiol mitigates secondary genital injury after thoracic trauma by regulating systemic inflammation and hormone receptor signaling.
Scientific reportsProtective effects of dihydroartemisinin against sterile inflammation and oxidative stress in alveolar macrophages.
Biochimica et biophysica acta. General subjectsDownregulation of RORα by alcohol promotes TGFβ and α-SMA expression in mouse lung fibroblasts.
Frontiers in medicineOleic acid promotes lung injury in hypertriglyceridaemia-associated acute pancreatitis via the PIEZO1/NR4A1/CPT1A axis impairing endothelial fatty acid oxidation.
GutElevated serum peroxiredoxin 1 is a biomarker of multiorgan failure in ARDS.
BMJ open respiratory researchTanreqing injection regulates Sema7a/Plxnc1 signaling pathway mediated neutrophil extracellular trap formation to alleviate lipopolysaccharide-induced acute lung injury.
Journal of ethnopharmacologyβ-Hydroxy-β-methylbutyrate attenuates sepsis-associated lung injury by regulating NF-κB p65-mediated inflammation, ER stress and mitochondrial apoptosis in a rat model.
Naunyn-Schmiedeberg's archives of pharmacologySorting nexin 10 knockdown: new strategies for alleviating sepsis-associated acute lung injury.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicasRetrospective Assessment of the Oxygenation Index in Dogs Undergoing Mechanical Ventilation for Primary Pulmonary Parenchymal Disease.
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)Xuanqing Hefa formula relieves sepsis-triggered acute lung injury by targeting the NLRP3/Caspase-1 pyroptosis mechanism.
Frontiers in immunologyFuzheng Jiedu Formula Ameliorates Acute Lung Injury by Modulating Gut Microbiota to Enhance Short-Chain Fatty Acid.
Journal of inflammation researchExpert recommendations for setting and adjusting airway pressure release ventilation based on clinical experience and basic science evidence.
Frontiers in medicineAlexithymia in patients with posttraumatic stress disorder: A meta-analysis.
L'EncephalePolydatin attenuates LPS-induced acute lung injury in rats via targeting HSP90AB1.
Journal of ethnopharmacologyMitsugumin 53 protects against smoke inhalation lung injury via suppressing the proinflammatory response in a rat model.
Free radical biology & medicinePKM2 from hyperactive neuron aggravate lung injury post-stroke by promoting FOXO3A/TXNIP mitochondria translocation in mice.
Redox biologyMST1 modulates inflammation by inhibiting BNIP3 -dependent mitophagy via the JNK/p53 pathway in acute lung injury.
Tissue & cellLimb remote ischemic preconditioning attenuates biomarkers of acute lung injury and inflammation during thoracoscopic lobectomy: a randomized controlled trial.
Clinics (Sao Paulo, Brazil)An immune-mediated effect of the antibiotic cefiderocol on LPS-induced acute lung injury.
Antimicrobial agents and chemotherapyInvestigation of the Protective Effect of Stemona Alkaloids on Acute Lung Injury via LC-MS/MS-Based Sphingolipid Metabolomic Profiling.
Journal of mass spectrometry : JMSIdentification and Validation of Liver Transplantation-Induced Acute Lung Injury Biomarkers Using a Bioinformatics and Experimental Approach.
Annals of transplantationAn indoloquinolinone 3a alleviates lipopolysaccharide-induced acute lung injury by modulating the NF-κB and AMPK/Nrf2 signaling pathways.
International immunopharmacologyDiscovery of Chromone Derivatives as Selective BLT1 Inhibitors for Alleviating Acute Lung Injury and Sepsis.
Journal of medicinal chemistrySmart nebulized ROS-responsive hydrogel microspheres loaded with UC-MSCs-derived exosomes for the treatment of acute lung injury.
Materials today. BioDigoxin attenuates LPS-induced acute lung injury in mice via NF-κB and HIF-1α inhibition.
Biomolecules & biomedicineTargeting TRAF7: a new approach to modulate AKT in acute lung injury.
Science bulletinA multi-omics approach to decipher the protective mechanism of Myristica fragrans against acute lung injury.
Journal of ethnopharmacologyCepharanthine protects against lipopolysaccharide-induced acute lung injury in mice by blocking NLRP3 inflammasome activation.
International immunopharmacologyBrain-derived neurotrophic factor and the derived dodecapeptide function as Toll-like receptor 4 antagonists in acute lung injury.
Nature communicationsβ - sitosterol promotes the SUMOylation of DRP1 in alveolar macrophages and alleviates sepsis-associated acute lung injury.
Biochemical pharmacologyNecroptosis mediated by FKBP5 in alveolar fibroblasts drives Pseudomonas aeruginosa-induced acute lung injury.
International immunopharmacologyIFIT3 stabilizes STING via USP18 to drive M1 macrophage polarization and early inflammation in acute lung injury.
Cellular and molecular life sciences : CMLSDecoding the lncRNA-miRNA-mRNA network in sepsis-induced lung injury: from pathogenesis to extracellular vesicle-based therapy.
Frontiers in immunologyThe Novel Soluble Guanylate Cyclase Stimulator Attenuates Acute Lung Injury via Inhibiting Pericyte Phenotypic Transition.
International journal of molecular sciencesRemimazolam alleviates acute lung injury by inhibiting ferroptosis: a multi-omics system pharmacology approach with experimental validation.
European journal of medical researchEfficacy of sivelestat sodium for patients with acute lung injury and acute respiratory distress syndrome: a protocol for systematic review and meta-analysis.
Systematic reviewsSangbaipi Decoction mitigates influenza pneumonia in mice by inhibiting ZBP1-mediated PANoptosis.
Journal of ethnopharmacologyEngineered CCR2 Cell Membrane-Wrapped Cepharanthine Liposomes for Potential Targeted Attenuation of Acute Lung Injury.
CellsAdipose Tissue-Derived Exosome and miR-142a-3p Alleviate Acute Lung Injury by Inhibiting HMGB1-Driven Autophagy.
CellsInvolvement of Non-Muscle Myosin Light Chain Kinase Nitration in Molecular Regulation of Inflammation-Induced Endothelial Cell Barrier Dysfunction.
CellsA Novel Precision-cut lung slice stretch model using removable inflation materials.
bioRxiv : the preprint server for biologyPlatelet membrane-camouflaged matrine biomimetic nanoparticles for efficient acute lung injury therapy.
iScienceLiang-Ge-San, a classic Chinese prescription, stimulates macrophage-secreted exosomal miR-21 to ameliorate lipopolysaccharide-induced acute lung injury through the regulation of PTEN/PI3K/AKT signaling.
Journal of natural medicinesCPAP and high-flow nasal oxygen also reduce lung, diaphragm, and accessory muscle injury in experimental self-inflicted lung injury.
Scientific reportsMultiomic analyses of longitudinal plasma samples identify thromboinflammation endotypes and trajectories in patients with trauma.
Science translational medicineBibliometric Analysis of Published Articles on Acute Pancreatitis and Acute Lung Injury from 2004 to 2024.
Clinical laboratoryCurcumin Attenuates Lipopolysaccharide-Induced Acute Lung Injury Through Anti-Inflammatory Effects in RAW Cells.
Chonnam medical journalHypoxia-preconditioned mesenchymal stromal cell-derived exosomes attenuate LPS-induced acute lung injury and early epithelial remodeling in mice: evidence for a miR-486a-5p-Skp2-GATA4 axis.
Respiratory researchNDRG1 aggravates Sepsis-Induced acute lung injury via PKM2-dependent activation of STAT3 and NF-κB signaling.
BMC immunologyGinkgetin alleviates sepsis-induced acute lung injury by promoting autophagy via inhibiting ubiquitination of Laptm5 in macrophages.
Phytomedicine : international journal of phytotherapy and phytopharmacologySecreted RCN3 acts as an early epithelial-fibroblast mediator via TGFβR1-Smad signaling in post-ALI pulmonary fibrosis.
Cell communication and signaling : CCSInterpretation of the efficacy-oriented components of decoction pieces in compounds based on the spectrum-effect relationship: Huangqin Qingfei decoction as an example.
Chinese medicineMachine Learning Approaches for Precision Risk Assessment of Transfusion Adverse Reactions: A Scikit-learn-Based Review.
Journal of visualized experiments : JoVENanotherapy for acute pancreatitis: a systematic review of experimental strategies and mechanisms of action.
Discover nano650 nm red-light therapy attenuates sepsis-induced acute lung injury via adiponectin-mediated immune-metabolic reprogramming.
Frontiers in immunologyExtracellular Vesicles Coordinate Bacterial Cloaking in Lung Epithelial Cells to Alleviate Acute Inflammatory Injury.
Journal of extracellular vesiclesEndothelium-Treg Communication Through Extracellular Vesicle Transfer Exacerbates Acute Respiratory Distress Syndrome.
Journal of extracellular vesiclesA macrophage-mimetic nanocarrier co-loaded with geraniol and FK13-a1 for MRSA-induced acute lung injury.
Drug deliveryIntranasal curcumin mitigates paraquat-induced oxidative lung damage via involvement of neutrophil extracellular traps (NETs) in mice model.
Naunyn-Schmiedeberg's archives of pharmacologyHU308, A Selective Cannabinoid Type-2 Receptor Agonist, Mitigates SARS-CoV-2 Spike Protein-Induced Acute Lung Injury in Mice.
LungPhytotherapeutic potential of Bauhinia purpurea Linn. in hyperoxic lung injury: Insights from in vivo, network pharmacology and in silico analyses.
Journal of ethnopharmacologySIRT3-mediated mitophagy by deacetylating ATP5F1A involved in the protective effects of SIGMAR1/Sigma-1 receptor against ferroptosis and microvascular hyperpermeability in lipopolysaccharide-induced acute lung injury.
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- C3 as a sensitive biomarker of alveolocapillary barrier integrity in acute lung injury: Protective modulation by enoxaparin.
- Efficacy of heparin in respiratory support of near-term rabbits with meconium-induced acute lung injury: Linear regression model analyses.
- Endogenous "Time Bomb" - Mislocalized Phospholipase A2 as a Critical Mediator of Ultra-Rapid Mortality in Sepsis and Acute Lung Injury.
- Prognostic significance of serum apelin-13 and galectin-3 concentrations as potential indicators of severity and mortality in pediatric acute respiratory distress syndrome.
- Aerosolized adenoviral IL4/IL10 delivery alleviates LPS-induced acute lung injury.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences· 2026· PMID 41864520mais citado
- Kindlins in the cardiovascular system: from development to pathogenesis.
- Attenuation of cGAS-STING signaling-mediated lung inflammation during infection through autophagy induction by bioactive nanodevices.
- Atractylenolide II alleviates LPS-induced acute lung injury in A549 cells via the TNIP2/NF-κB pathway.
- Transcriptomics and network pharmacology reveal that baicalin alleviates acute lung injury induced by H1N1 via targeting STAT1.
- Fecal microbiota transplantation alleviates sepsis-induced acute lung injury by improving mitochondrial function.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:178320(Orphanet)
- MONDO:0015796(MONDO)
- GARD:20146(GARD (NIH))
- Busca completa no PubMed(PubMed)
- Q4677935(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
