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Pneumonia intersticial aguda
ORPHA:79126CID-10 · J84.1CID-11 · CB03.0DOENÇA RARA

Pneumonia intersticial aguda (PIA), também conhecida como síndrome de Hamman-Rich, é um tipo de pneumonia intersticial idiopática (ou seja, de causa desconhecida) que avança rápido e tem características únicas que só são visíveis ao microscópio.

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Introdução

O que você precisa saber de cara

📋

Pneumonia intersticial aguda (PIA), também conhecida como síndrome de Hamman-Rich, é um tipo de pneumonia intersticial idiopática (ou seja, de causa desconhecida) que avança rápido e tem características únicas que só são visíveis ao microscópio.

Pesquisas ativas
2 ensaios
16 total registrados no ClinicalTrials.gov
Publicações científicas
396 artigos
Último publicado: 2026 Apr 14

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
1-9 / 100 000
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
3.8
Europe
Início
Adult
🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: J84.1
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Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🫁
Pulmão
10 sintomas
❤️
Coração
2 sintomas
🩸
Sangue
1 sintomas
💪
Músculos
1 sintomas

+ 19 sintomas em outras categorias

Características mais comuns

90%prev.
Padrão reticulonodular na TC de alta resolução pulmonar
Muito frequente (99-80%)
90%prev.
Padrão nodular na TCAR pulmonar
Muito frequente (99-80%)
90%prev.
Bronquiectasia
Muito frequente (99-80%)
90%prev.
Espessamento intersticial peribroncovascular
Muito frequente (99-80%)
90%prev.
Insuficiência respiratória
Muito frequente (99-80%)
90%prev.
Espessamento do septo interlobular na HRCT pulmonar
Muito frequente (99-80%)
33sintomas
Muito frequente (11)
Frequente (9)
Ocasional (13)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 33 características clínicas mais associadas, ordenadas por frequência.

Padrão reticulonodular na TC de alta resolução pulmonarReticulonodular pattern on pulmonary HRCT
Muito frequente (99-80%)90%
Padrão nodular na TCAR pulmonarNodular pattern on pulmonary HRCT
Muito frequente (99-80%)90%
BronquiectasiaBronchiectasis
Muito frequente (99-80%)90%
Espessamento intersticial peribroncovascularPeribronchovascular interstitial thickening
Muito frequente (99-80%)90%
Insuficiência respiratóriaRespiratory failure
Muito frequente (99-80%)90%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico396PubMed
Últimos 10 anos140publicações
Pico202317 papers
Linha do tempo
2026Hoje · 2026🧪 2003Primeiro ensaio clínico📈 2023Ano de pico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
2Fase 22
·Pré-clínico6
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 8 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Pneumonia intersticial aguda

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

Pesquisa e ensaios clínicos

16 ensaios clínicos encontrados, 2 ativos.

Distribuição por fase
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
142 papers (10 anos)
#1

Determining chronicity and frequency of histologic lung lesions in feedyard cattle mortalities.

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc2026 Mar 21

Several etiologic factors contribute to bovine respiratory disease, the primary cause of feedyard mortality. We performed a cross-sectional observational study to determine the frequency and chronicity of lesions in fatal feedyard pneumonia cases. Postmortem examinations were performed (n = 443), and 2 lung samples were collected from each animal. Histologic sections were scored using 10 classifications: 5 types of bronchopneumonia (BP; 3 acute, 2 chronic), 4 types of interstitial pneumonia (IP; 2 chronic, 2 acute), and 1 category for other findings. Cases with chronicity in either section were classified as chronic. Results from both lung sections were combined into a case-level diagnosis of BP, IP, or BP with IP (BIP). After exclusions because of autolysis or missing data, our diagnosis frequencies for 352 cases were: BP (150; 42.6%), IP (86; 24.4%), BIP (71; 20.2%), and Other (45; 12.8%). Of cases with an IP component, chronic lymphoplasmacytic IP (CLIP) was identified in 59 of 157 (37.6%) cases. A generalized linear model was used to evaluate the probability of case-level chronicity and potential associations with diagnosis and days on feed. Model-estimated probability of chronic lesions was higher in cases with IP (51% IP; 60% BIP) compared with BP (38%). Of 71 BIP cases, 27 had acute BP and acute IP; 18 had acute IP and chronic BP; 0 had chronic IP and acute BP; 5 had chronic IP and chronic BP; 14 had CLIP and acute BP; and 7 had CLIP and chronic BP. In our final dataset of 352 feedyard pneumonia cases, IP was found histologically in the lungs of 157 cases, either alone or in conjunction with BP; cases with an IP component were more likely to have chronic lesions. Acute interstitial pneumonia (AIP, also known as Hamman–Rich syndrome) is an acute, rapidly progressive idiopathic pulmonary disease that often leads to fulminant respiratory failure and acute respiratory distress syndrome (ARDS). AIP can be distinguished clinically from other types of interstitial pneumonia by the rapid onset of respiratory failure in a patient without preexisting lung disease. Louis Hamman and Arnold Rich first described AIP in 1935 as a fulminating diffuse interstitial fibrosis of the lungs. In 1986, Katzenstein introduced the term AIP, differentiating it from the group of chronic interstitial pneumonias. The American Thoracic Society and European Respiratory Society classify AIP as a major idiopathic interstitial pneumonia, compared with other rare or unclassified idiopathic interstitial pneumonias.

#2

Scoping review of clinical signs, etiologies, pathology findings, risk factors, and treatments of acute interstitial pneumonia in North American feedlot cattle.

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc2026 Feb 17

Acute interstitial pneumonia (AIP) has been a recognized bovine respiratory disease for many decades, yet the sporadic occurrences of AIP in feedlot cattle are poorly understood. We searched 3 databases (PubMed, CABI Direct Library, AGRICOLA) for primary literature on North American feedlot cattle, with a focus on interstitial pneumonia. We comprehensively reviewed reports of clinical signs, pathology findings, etiologies, risk factors, and treatments associated with AIP in feedlot cattle and identified gaps in knowledge. We included 19 peer-reviewed studies from 1976 to 2023. In 6 articles, the most common clinical signs for diagnosing AIP were severe dyspnea, increased expiratory effort, and grunting while breathing. In the 17 articles that provided detailed descriptions of the pathology and diagnostic features of AIP, consistent postmortem examination findings were interlobular edema and emphysema, a checkerboard appearance, and diffusely overinflated lung lobes. The most frequent histopathology findings were hyaline membranes, type II pneumocyte hyperplasia, and obliterative bronchiolitis. Although some potential etiologies, such as bovine respiratory syncytial virus (BRSV) and 3-methylindole (3MI), have been evaluated, no definitive cause has been identified consistently. Risk factors significantly associated with AIP in multiple studies included heifers, clinical onset at >45 days on feed (DOF), death at >78 DOF, and summer; the exact mechanisms remain unclear. The absence of standardized diagnostic criteria, along with a lack of research into potential effective prevention or treatment, underscore the need for further study to clarify the causes, diagnosis, and treatment of AIP in feedlot cattle.

#3

Drug-induced Lung Injury Caused by Azacitidine That Was Not Treated with Drugs.

Internal medicine (Tokyo, Japan)2026 Jan 15

An 83-year-old male was hospitalized with pneumonia while receiving azacitidine for myelodysplastic syndrome. Despite treatment with antimicrobial agents, his pneumonia worsened. Bronchoscopy revealed organizing pneumonia (OP). This condition was thought to be a drug-induced lung injury caused by azacitidine. As the patient had no subjective symptoms, antimicrobial therapy was discontinued and the patient was monitored closely. Thereafter, the pneumonia gradually improved. Drug-induced lung injury caused by azacitidine, which has few subjective symptoms, can be treated without steroids. However, it should be noted that the condition may become resistant to steroid therapy if it progresses to acute interstitial pneumonia or if azacitidine treatment is continued.

#4

Economic outcomes associated with acute interstitial pneumonia in Central U.S. High Plains feedyards.

Translational animal science2025

The objective of this study was to evaluate net returns for Central U.S. high plains feedyard cattle identified with acute interstitial pneumonia (AIP) ante-mortem and postmortem (n = 5,339) and to examine economic outcomes across sex, placement weight, and number of AIP treatments. A decision tree framework was implemented to estimate net returns of cattle identified with AIP, where decision nodes represented choices made by the producer, and branches represented potential outcomes following a decision. The initial decision node was whether to treat cattle for AIP after the first identification for illness or to sell (cull) soon after diagnosis at reduced weight and price compared to cattle in the cohort sold at finished weight. Following initial treatment, cattle that remained in the feedyard either finished (with or without further treatment), were culled, or died after additional diagnosis and treatment. Probabilities of incidents at each node were obtained from the data distribution. This research indicates that estimated net returns for feedyard cattle identified with AIP vary by sex, placement weight, and number of AIP treatments. The expected net return to feeding healthy cattle was $193.67/animal, while the expected net return for cattle that finished after AIP treatment was -$639.71/animal for cattle treated once for AIP, -$612.41/animal for those treated twice for AIP, and -$529.57/animal for those treated three or more times for AIP. However, other health indicators and risk factors not included in this analysis should be considered when deciding whether to keep or cull feedyard cattle identified with AIP.

#5

Determining Frequency of Multiple Organ System Involvement and Concurrent Lesions Identified in Feedyard Mortalities and Potential Associations with Cattle Demographics.

Veterinary sciences2025 Jul 15

Necropsies are commonly used to diagnose the causes of death in feedyard cattle, but the documentation of multiple organ system involvement and concurrent lesions is limited. This observational study aimed to determine the frequency of such findings and their associations with animal demographics. Systemic necropsies were conducted for 889 cattle mortalities with minimal autolysis across six feedyards in the Central High Plains during the summers of 2022 and 2023. Lesions and abnormalities were recorded along with arrival weight, sex, days on feed (DOFs), and number of treatments. The results showed that 72% of mortalities had more than one gross lesion, averaging 2.3 lesions per animal. The most common organ systems affected together were digestive and pulmonary (19%), followed by cardiovascular, digestive, and pulmonary (6%), and cardiovascular and pulmonary (5%). Common concurrent lesions included bronchopneumonia with an interstitial pattern (BIP) and gastrointestinal lesions (GI) (8%), bronchopneumonia and GI (7%), and acute interstitial pneumonia (AIP) and GI (3%). A generalized linear mixed effects model revealed that the likelihood of multiple lesions increased with DOFs (p = 0.02). These findings highlight the value of thorough necropsy documentation to enhance our understanding of disease and guide improved feedyard management and treatment practices.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC140 artigos no totalmostrando 139

2026

Determining chronicity and frequency of histologic lung lesions in feedyard cattle mortalities.

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
2026

Scoping review of clinical signs, etiologies, pathology findings, risk factors, and treatments of acute interstitial pneumonia in North American feedlot cattle.

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
2025

Prognostic comparison of acute exacerbations across idiopathic interstitial pneumonia subtypes: A nationwide observational study.

Respiratory investigation
2025

Drug-induced interstitial lung disease caused by gefitinib in the treatment of non-small cell lung cancer: A case report.

Molecular and clinical oncology
2025

Economic outcomes associated with acute interstitial pneumonia in Central U.S. High Plains feedyards.

Translational animal science
2025

Update of the international multidisciplinary classification of the interstitial pneumonias: an ERS/ATS statement.

The European respiratory journal
2025

Determining Frequency of Multiple Organ System Involvement and Concurrent Lesions Identified in Feedyard Mortalities and Potential Associations with Cattle Demographics.

Veterinary sciences
2026

Drug-induced Lung Injury Caused by Azacitidine That Was Not Treated with Drugs.

Internal medicine (Tokyo, Japan)
2025

Korean Guidelines for Diagnosis and Management of Interstitial Lung Diseases.

Tuberculosis and respiratory diseases
2025

Examining the Role of Corticosteroids in the Management of Acute Interstitial Pneumonia: A Systematic Review.

Journal of clinical medicine research
2025

Diagnostic Utility of Bronchoalveolar Lavage Flow Cytometric Leukocyte Profiling in Interstitial Lung Disease and Infection.

Biomolecules
2025

Primary pulmonary angiosarcoma mimicking acute interstitial pneumonia - a diagnostic challenge: A case report.

Medicine
2025

Rare Presentation of Rituximab-induced Interstitial Lung Disease in a Patient with Pemphigus Vulgaris.

The Journal of the Association of Physicians of India
2025

Korean Guidelines for the Diagnosis and Management of Interstitial Lung Disease: Other Forms of Interstitial Lung Disease.

Tuberculosis and respiratory diseases
2025

Case report: Pulmonary non-Langerhans cell histiocytosis in a dog with acute interstitial granulomatous pneumonia.

Frontiers in veterinary science
2025

Epidemiologic Survey for Work-Related Idiopathic Interstitial Pneumonias Focusing on Idiopathic Pulmonary Fibrosis in Korea, 2010-2022.

Journal of occupational and environmental medicine
2024

Amyopathic Dermatomyositis with a Rapidly Progressing Interstitial Pneumonia.

European journal of case reports in internal medicine
2024

Integrative Genomic and Transcriptomic Analysis in Acute Interstitial Pneumonia.

Journal of cellular and molecular medicine
2024

Computed tomography patterns and clinical outcomes of radiation pneumonitis in non-small-cell lung cancer patients.

Acta radiologica open
2024

High-Resolution CT Patterns of Anti-PD1 Checkpoint Inhibitor-Related Pneumonitis in Patients With Lung Cancer.

Journal of computer assisted tomography
2024

The radiologist's role in detecting systemic anticancer therapy-related interstitial lung disease: an educational review.

Insights into imaging
2024

Rapid Progression of Acute Interstitial Pneumonia in a Patient with Low MDA-5 Antibody Titer.

The American journal of case reports
2024

Pulmonary manifestations of VEXAS syndrome with acute interstitial pneumonia and diffuse alveolar hemorrhage: a case report and literature review.

ARP rheumatology
2024

The Balance Between Intensive and Palliative Care in an Anti-melanoma Differentiation-Associated Gene 5 (MDA5) Antibody-Positive Acute Interstitial Pneumonia in a Nonagenarian: A Case Report.

Cureus
2024

Spontaneous regression of acute fibrinous organizing pneumonia induced by COVID-19 vaccination: A case report.

Respiratory investigation
2024

Fatal acute interstitial pneumonia induced by radiotherapy alone.

Quantitative imaging in medicine and surgery
2023

Trastuzumab Deruxtecan‒Related Interstitial Lung Disease/Pneumonitis: Computed Tomography Imaging Patterns to Guide Diagnosis and Management.

JCO precision oncology
2024

Histopathological pulmonary lesions in rhesus (Macaca mulatta) and cynomolgus (Macaca fascicularis) macaques experimentally infected with wild-type severe acute respiratory syndrome coronavirus 2.

Journal of comparative pathology
2023

Clinical Features and Outcomes of the Association of Co-Infections in Children with Laboratory-Confirmed Influenza during the 2022-2023 Season: A Romanian Perspective.

Viruses
2022

SUCCESSFULLY TREATED ACUTE INTERSTITIAL PNEUMONIA.

Acta clinica Croatica
2023

Case report of a child with spontaneous pneumomediastinum and subcutaneous emphysema.

The Journal of international medical research
2023

Epidemiology, pathogenesis, and diagnosis of Aleutian disease caused by Aleutian mink disease virus: A literature review with a perspective of genomic breeding for disease control in American mink (Neogale vison).

Virus research
2023

Epidemiological Factors Associated with Gross Diagnosis of Pulmonary Pathology in Feedyard Mortalities.

Veterinary sciences
2023

Treatment of refractory anti-melanoma differentiation-associated gene 5 anbibody-positive dermatomyositis complicated by rapidly progressing interstitial pulmonary disease: Two case reports.

World journal of clinical cases
2023

Imaging Features of Idiopathic Interstitial Lung Diseases.

Journal of thoracic imaging
2023

Lung pathology of natural Babesia rossi infection in dogs.

Journal of the South African Veterinary Association
2023

Serum Progranulin Level Might Differentiate Non-IPF ILD from IPF.

International journal of molecular sciences
2023

Determining Frequency of Common Pulmonary Gross and Histopathological Findings in Feedyard Fatalities.

Veterinary sciences
2023

A Novel Workflow to Create a Checkpoint Inhibitor Pneumonitis Patient Registry.

Cureus
2023

[Rapid evaluation of the early pathogen of severe Chlamydophila psittaci pneumonia by diagnostic bronchoscopy].

Zhonghua wei zhong bing ji jiu yi xue
2023

Image Classification and Automated Machine Learning to Classify Lung Pathologies in Deceased Feedlot Cattle.

Veterinary sciences
2023

Association of Clinical and Radiological Features with Disease Severity of Symptomatic Immune Checkpoint Inhibitor-Related Pneumonitis.

Diagnostics (Basel, Switzerland)
2023

Bronchopneumonia with interstitial pneumonia in feedlot cattle: Epidemiologic characteristics of affected animals.

Veterinary pathology
2023

Bronchopneumonia with interstitial pneumonia in beef feedlot cattle: Characterization and laboratory investigation.

Veterinary pathology
2022

Risk factors for rheumatoid arthritis-associated interstitial lung disease: a retrospective study.

Multidisciplinary respiratory medicine
2023

Morphological and functional findings in COVID-19 lung disease as compared to Pneumonia, ARDS, and High-Altitude Pulmonary Edema.

Respiratory physiology &amp; neurobiology
2022

Acute interstitial pneumonia due to amyopathic dermatomyositis.

Proceedings (Baylor University. Medical Center)
2022

[The role of artificial intelligence in assessing the progression of fibrosing lung diseases].

Terapevticheskii arkhiv
2022

Diagnostic value and safety of medical thoracoscopy under local anesthesia for unexplained diffuse interstitial lung disease: A retrospective study.

Chronic respiratory disease
2022

Acute Interstitial Pneumonia (Hamman-Rich Syndrome) in Lung Transplantation: A Case Series.

Transplantation proceedings
2022

Rituximab-Induced Interstitial Lung Disease: A Stitch in Time Saved Nine.

Cureus
2022

Acute interstitial pneumonia and the biology of 3-methylindole in feedlot cattle.

Animal health research reviews
2022

Expression of airway smooth muscle contractile proteins in children with acute interstitial pneumonia.

International journal of experimental pathology
2022

Comparative Histopathology of Bovine Acute Interstitial Pneumonia and Bovine Respiratory Syncytial Virus-Associated Interstitial Pneumonia.

Journal of comparative pathology
2022

Gammaherpesvirus Alters Alveolar Macrophages According to the Host Genetic Background and Promotes Beneficial Inflammatory Control over Pneumovirus Infection.

Viruses
2021

Pulmonary Tumor Embolism Microangiopathy: A Cause of Respiratory Failure in Advanced Malignancy.

South Dakota medicine : the journal of the South Dakota State Medical Association
2021

Anti-MDA5 antibody-positive clinically amyopathic dermatomyositis with diffuse alveolar damage diagnosed by transbronchial lung cryobiopsy: A case report.

Respirology case reports
2021

Spread of vimentin-immunoreactive cells within the plaque-like lesion in the spinal anterior horn of a patient with post-poliomyelitis syndrome.

Neuropathology : official journal of the Japanese Society of Neuropathology
2021

Ameliorative Effects of Oleuropein on Lipopolysaccharide-Induced Acute Lung Injury Model in Rats.

Inflammation
2021

Fibrotic Idiopathic Interstitial Lung Disease: The Molecular and Cellular Key Players.

International journal of molecular sciences
2021

Investigating the forensic pathological characteristics of systemic vasculitis: A retrospective study of 20 deaths caused by systemic vasculitis.

Journal of forensic and legal medicine
2021

Animal models of SARS-CoV-2 and COVID-19 for the development of prophylactic and therapeutic interventions.

Pharmacology &amp; therapeutics
2021

[Case report of severe acute eosinophilic pneumonia induced by amoxicillin].

Revue des maladies respiratoires
2021

Diagnostic imaging in acute interstitial pneumonia in foals: High variability of interpretation of chest radiographs and good conformity between ultrasonographic and post-mortem findings.

Veterinary radiology &amp; ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association
2021

Interstitial lung abnormality (ILA) and nonspecific interstitial pneumonia (NSIP).

European journal of radiology open
2021

Distribution of anti-melanoma differentiation associated gene 5 (MDA5) IgG subclasses in MDA5+ dermatomyositis.

Rheumatology (Oxford, England)
2021

Differential impacts of postoperative complications on patients' survival in completely resected non-small-cell lung cancer.

General thoracic and cardiovascular surgery
2021

Reston virus causes severe respiratory disease in young domestic pigs.

Proceedings of the National Academy of Sciences of the United States of America
2020

Imatinib Treatment for Bleomycin-Induced Pulmonary Toxicity.

Turkish thoracic journal
2020

[Acute interstitial pneumonia in a patient treated with methotrexate: Late-onset with neutrophilia and eosinophilia in bronchoalveolar lavage fluid].

Revue des maladies respiratoires
2021

COVID-19: A Great Mime or a Trigger Event of Autoimmune Manifestations?

Current rheumatology reviews
2021

Acute interstitial pneumonia in foals: A severe, multifactorial syndrome with lung tissue recovery in surviving foals.

Equine veterinary journal
2020

Hamman-Rich Syndrome: A Diagnosis of Exclusion in the COVID-19 Pandemic.

Cureus
2020

Immune-related adverse events on body CT in patients with small-cell lung cancer treated with immune-checkpoint inhibitors.

European journal of radiology
2021

Interstitial lung disease in patients with antisynthetase syndrome: a retrospective case series study.

Japanese journal of radiology
2020

Transient Lymphopenia and Interstitial Pneumonia With Endotheliitis in SARS-CoV-2-Infected Macaques.

The Journal of infectious diseases
2020

Clinical and Pathological Findings in SARS-CoV-2 Disease Outbreaks in Farmed Mink (Neovison vison).

Veterinary pathology
2020

Radiographic patterns of symptomatic radiation pneumonitis in lung cancer patients: Imaging predictors for clinical severity and outcome.

Lung cancer (Amsterdam, Netherlands)
2020

The emerging spectrum of cardiopulmonary pathology of the coronavirus disease 2019 (COVID-19): Report of 3 autopsies from Houston, Texas, and review of autopsy findings from other United States cities.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
2020

Acute interstitial pneumonia triggered by strenuous exercise.

Respiratory medicine case reports
2020

Outbreak of COVID-19 infection in children: fear and serenity.

European review for medical and pharmacological sciences
2020

Radiological Patterns of Drug-induced Interstitial Lung Disease (DILD) in Early-phase Oncology Clinical Trials.

Clinical cancer research : an official journal of the American Association for Cancer Research
2020

Rheumatologists' perspective on coronavirus disease 19 (COVID-19) and potential therapeutic targets.

Clinical rheumatology
2020

Resecting a giant malignant lung tumor in a patient with unilateral acute interstitial pneumonitis.

Respiratory investigation
2020

Outbreak investigation of septicemic salmonellosis in calves.

Journal of infection in developing countries
2019

Time-course transcriptomic alterations reflect the pathophysiology of polyhexamethylene guanidine phosphate-induced lung injury in rats.

Inhalation toxicology
2020

Lesions Observed Post Mortem in Post-hatchling Loggerhead Sea Turtles (Caretta caretta) from a Head Start Programme.

Journal of comparative pathology
2019

Viral Pneumonia Requiring Differentiation from Acute and Progressive Diffuse Interstitial Lung Diseases.

Internal medicine (Tokyo, Japan)
2019

Anaplastic lymphoma kinase inhibitor related pneumonitis in patients with non-small cell lung cancer: Clinical and radiologic characteristics and risk factors.

Medicine
2019

Immune Checkpoint Inhibitor Therapy-related Pneumonitis: Patterns and Management.

Radiographics : a review publication of the Radiological Society of North America, Inc
2019

An Elusive Case of Acute Interstitial Pneumonia.

Cureus
2019

Korean Guidelines for Diagnosis and Management of Interstitial Lung Diseases: Part 1. Introduction.

Tuberculosis and respiratory diseases
2019

Interstitial pneumonia suspected during regorafenib administration and exacerbated by subsequent therapy with lenvatinib for unresectable hepatocellular carcinoma.

Clinical journal of gastroenterology
2019

Up-regulation of THY1 attenuates interstitial pulmonary fibrosis and promotes lung fibroblast apoptosis during acute interstitial pneumonia by blockade of the WNT signaling pathway.

Cell cycle (Georgetown, Tex.)
2019

Molecular hydrogen attenuates gefitinib-induced exacerbation of naphthalene-evoked acute lung injury through a reduction in oxidative stress and inflammation.

Laboratory investigation; a journal of technical methods and pathology
2019

Staphylococcus pseudintermedius septicemia in puppies after elective cesarean section: confirmed transmission via dam's milk.

BMC veterinary research
2018

Preliminary evidence that hydrostatic edema may contribute to the formation of diffuse alveolar damage in a Holstein calf model.

F1000Research
2019

Clinical Features of Anti-MDA5 Antibody-positive Rapidly Progressive Interstitial Lung Disease without Signs of Dermatomyositis.

Internal medicine (Tokyo, Japan)
2018

Idiopathic interstitial pneumonias: review of the latest American Thoracic Society/European Respiratory Society classification.

Radiologia brasileira
2018

Pneumocystis jirovecii infection in patients with acute interstitial pneumonia.

Revista clinica espanola
2018

Acute interstitial pneumonia as first presentation of anti-synthetase syndrome: an atypical case.

Oxford medical case reports
2018

Clinical presentation and pathology of suspected vector transmitted African horse sickness in South African domestic dogs from 2006 to 2017.

The Veterinary record
2018

Time course of polyhexamethyleneguanidine phosphate-induced lung inflammation and fibrosis in mice.

Toxicology and applied pharmacology
2018

Respiratory Mites ( Orthohalarachne diminuata) and β-hemolytic Streptococci-Associated Bronchopneumonia Outbreak in South American Fur Seal Pups ( Arctocephalus australis).

Journal of wildlife diseases
2018

Extracorporeal Membrane Oxygenation for Refractory Severe Respiratory Failure in Acute Interstitial Pneumonia.

Artificial organs
2018

Baseline peripheral blood neutrophil-to-lymphocyte ratio could predict survival in patients with adult polymyositis and dermatomyositis: A retrospective observational study.

PloS one
2018

Acute respiratory failure due to diffuse parenchymal lung diseases in a respiratory intensive care unit of North India.

Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG
2018

Organizing pneumonia revisited: insights and uncertainties from a series of 67 patients.

Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG
2017

[Efficacy and safety of transbronchial cryobiopsy in the etiologic diagnosis of diffuse lung disease].

Zhonghua yi xue za zhi
2017

[Clinical features of acute diffuse pulmonary exudative disorders].

Zhonghua yi xue za zhi
2017

Abruptio Placentae with Type II Respiratory Failure Secondary to Acute Interstitial Pneumonia Responsive to Steroids.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
2017

[Manifestations of the connective tissue associated interstitial lung disease under high resolution computed tomography].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
2017

A 45-Year-Old Woman with Acute Interstitial Pneumonia (Hamman-Rich Syndrome).

Turkish journal of anaesthesiology and reanimation
2017

An Unusual Cause of Organizing Pneumonia: Hydrocarbon Pneumonitis.

Journal of clinical and diagnostic research : JCDR
2017

[Unusual histopathological picture of acute lung injury in different stages of resorption with predominance of organizing pneumonia in a young man with influenza A (H1N1)].

Ceskoslovenska patologie
2017

Pemetrexed-related interstitial lung disease reported from post marketing surveillance (malignant pleural mesothelioma/non-small cell lung cancer).

Japanese journal of clinical oncology
2016

Characteristics and Prognostic Impact of Pneumonitis during Systemic Anti-Cancer Therapy in Patients with Advanced Non-Small-Cell Lung Cancer.

PloS one
2016

Successful treatment of gemcitabine-induced acute interstitial pneumonia with imatinib mesylate: a case report.

BMC cancer
2017

Exacerbation of gemcitabine-related pneumonia during radiotherapy for extrapulmonary lesion.

International cancer conference journal
2016

Imaging of Acute Lung Injury.

Radiologic clinics of North America
2016

Severe Toxocariasis in Children-Diagnostic Difficulties.

Current health sciences journal
2016

PD-1 Inhibitor-Related Pneumonitis in Advanced Cancer Patients: Radiographic Patterns and Clinical Course.

Clinical cancer research : an official journal of the American Association for Cancer Research
2016

Genetic parameters estimated at receiving for circulating cortisol, immunoglobulin G, interleukin 8, and incidence of bovine respiratory disease in feedlot beef steers.

Journal of animal science
2016

High-resolution CT findings of idiopathic pneumonia syndrome after haematopoietic stem cell transplantation: based on the updated concept of idiopathic pneumonia syndrome by the American Thoracic Society in 2011.

Clinical radiology
2016

Gottron Papules and Gottron Sign with Ulceration: A Distinctive Cutaneous Feature in a Subset of Patients with Classic Dermatomyositis and Clinically Amyopathic Dermatomyositis.

The Journal of rheumatology
2016

Acute and subacute idiopathic interstitial pneumonias.

Respirology (Carlton, Vic.)
2015

[A "difficult" pneumonia: problems of differential diagnosis].

Voenno-meditsinskii zhurnal
2015

American Thoracic Society-European Respiratory Society Classification of the Idiopathic Interstitial Pneumonias: Advances in Knowledge since 2002.

Radiographics : a review publication of the Radiological Society of North America, Inc
2015

Clinico-pathological Analysis of the Lungs from Patients with Lung Transplantation in a Single Institute in Korea.

Journal of Korean medical science
2015

Interstitial lung diseases in the hospitalized patient.

BMC medicine
2014

Acquired hemophilia A as a cause of recurrent bleeding into the pleural cavity - case report and literature review.

Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery
2015

Feedlot Acute Interstitial Pneumonia.

The Veterinary clinics of North America. Food animal practice
2015

Ultrasound in Rheumatologic Interstitial Lung Disease: A Case Report of Nonspecific Interstitial Pneumonia in Rheumatoid Arthritis.

Case reports in rheumatology
2014

Acute interstitial lung disease in a patient with anaplastic lymphoma kinase-positive non-small-cell lung cancer after crizotinib therapy.

Oxford medical case reports
2015

Interstitial pneumonia induced by sorafenib in a patient with hepatocellular carcinoma: An autopsy case report.

Oncology letters
2015

HRCT score and serum ferritin level are factors associated to the 1-year mortality of acute interstitial lung disease in clinically amyopathic dermatomyositis patients.

Clinical rheumatology
2015

A pilot study: a combined therapy using polymyxin-B hemoperfusion and extracorporeal membrane oxygenation for acute exacerbation of interstitial pneumonia.

Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG
2015

Reconsideration of discrepancies between clinical and histopathological features in acute eosinophilic pneumonia.

Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG
2015

Leflunomide-induced acute interstitial pneumonia in a patient treated for rheumatoid arthritis.

Pneumonologia i alergologia polska
Ver todos os 140 no EuropePMC

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Doenças relacionadas

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Determining chronicity and frequency of histologic lung lesions in feedyard cattle mortalities.
    Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc· 2026· PMID 41863156mais citado
  2. Scoping review of clinical signs, etiologies, pathology findings, risk factors, and treatments of acute interstitial pneumonia in North American feedlot cattle.
    Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc· 2026· PMID 41704011mais citado
  3. Drug-induced Lung Injury Caused by Azacitidine That Was Not Treated with Drugs.
    Internal medicine (Tokyo, Japan)· 2026· PMID 40571615mais citado
  4. Economic outcomes associated with acute interstitial pneumonia in Central U.S. High Plains feedyards.
    Translational animal science· 2025· PMID 40799626mais citado
  5. Determining Frequency of Multiple Organ System Involvement and Concurrent Lesions Identified in Feedyard Mortalities and Potential Associations with Cattle Demographics.
    Veterinary sciences· 2025· PMID 40711326mais citado
  6. Isolation and characterization of a red panda amdoparvovirus causing fatal respiratory disease: Identification of VP2-S447 as a key determinant of acute lung injury.
    Virulence· 2026· PMID 41979076recente
  7. Acute Interstitial Pneumonia(Archived).
    · 2026· PMID 32119316recente
  8. Prognostic comparison of acute exacerbations across idiopathic interstitial pneumonia subtypes: A nationwide observational study.
    Respir Investig· 2025· PMID 41056590recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:79126(Orphanet)
  2. MONDO:0019203(MONDO)
  3. GARD:12835(GARD (NIH))
  4. Busca completa no PubMed(PubMed)
  5. Artigo Wikipedia(Wikipedia)
  6. Q424258(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Pneumonia intersticial aguda
Compêndio · Raras BR

Pneumonia intersticial aguda

ORPHA:79126 · MONDO:0019203
Prevalência
1-9 / 100 000
Herança
Unknown
CID-10
J84.1 · Outras doenças pulmonares intersticiais com fibrose
CID-11
Ensaios
2 ativos
Início
Adult
Prevalência
3.8 (Europe)
MedGen
UMLS
C1279945
Repurposing
47 candidatos
atovaquonemitochondrial electron transport inhibitor
azithromycinbacterial 50S ribosomal subunit inhibitor
benzylpenicillinpenicillin binding protein inhibitor
+17 outros
EuropePMC
Wikidata
Wikipedia
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