Raras
Buscar doenças, sintomas, genes...
Síndrome de encarceramento
ORPHA:2406CID-10 · G83.8CID-11 · 8E45DOENÇA RARA

A Síndrome do Encarceramento (LIS) é uma condição neurológica em que a pessoa mantém os olhos abertos, mas apresenta paralisia total ou parcial dos quatro membros (braços e pernas) e incapacidade de falar. Apesar disso, a capacidade de pensar e compreender permanece intacta, e a comunicação principal se dá por meio de movimentos verticais dos olhos ou piscadas.

Mantido por Agente Raras·Colaborar como especialista →

Introdução

O que você precisa saber de cara

📋

A Síndrome do Encarceramento (LIS) é uma condição neurológica em que a pessoa mantém os olhos abertos, mas apresenta paralisia total ou parcial dos quatro membros (braços e pernas) e incapacidade de falar. Apesar disso, a capacidade de pensar e compreender permanece intacta, e a comunicação principal se dá por meio de movimentos verticais dos olhos ou piscadas.

Pesquisas ativas
8 ensaios
21 total registrados no ClinicalTrials.gov
Publicações científicas
871 artigos
Último publicado: 2026 Mar 30

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
<1 / 1 000 000
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Worldwide
Casos conhecidos
33
pacientes catalogados
Início
All ages
🏥
SUS: Cobertura mínimaScore: 20%
Triagem neonatal (Fase 5)CID-10: G83.8
🇧🇷Dados SUS / DATASUS
PROCEDIMENTOS SIGTAP (2)
0202010694
Sequenciamento completo do exoma (WES)genetic_test
0301070040
Atendimento em reabilitação — doenças rarasrehabilitation
Você se identifica com essa condição?
O Raras está aqui pra te apoiar — com ou sem diagnóstico

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Entender a doença

Do básico ao detalhe, leia no seu ritmo

Preparando trilha educativa...

Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🧠
Neurológico
4 sintomas
🫁
Pulmão
2 sintomas
👂
Ouvidos
1 sintomas
📏
Crescimento
1 sintomas
👁️
Olhos
1 sintomas

+ 7 sintomas em outras categorias

Características mais comuns

90%prev.
Tetraplegia
Muito frequente (99-80%)
90%prev.
Espasticidade
Muito frequente (99-80%)
90%prev.
Paralisia cerebral
Muito frequente (99-80%)
90%prev.
Comportamento atípico
Muito frequente (99-80%)
90%prev.
Diplopia
Muito frequente (99-80%)
90%prev.
Anartria
Muito frequente (99-80%)
16sintomas
Muito frequente (12)
Frequente (3)
Ocasional (1)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 16 características clínicas mais associadas, ordenadas por frequência.

Tetraplegia
Muito frequente (99-80%)90%
EspasticidadeSpasticity
Muito frequente (99-80%)90%
Paralisia cerebralCerebral palsy
Muito frequente (99-80%)90%
Comportamento atípicoAtypical behavior
Muito frequente (99-80%)90%
Diplopia
Muito frequente (99-80%)90%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico871PubMed
Últimos 10 anos200publicações
Pico202439 papers
Linha do tempo
2026Hoje · 2026🧪 2009Primeiro ensaio clínico📈 2024Ano de pico
Publicações por ano (últimos 10 anos)

Triagem neonatal (Teste do Pezinho)

👶
Teste: qPCR para deleção de SMN1 em sangue seco
Fase 5 do PNTNpending
Incidência no Brasil: 1:10.000

A triagem neonatal permite diagnóstico precoce e início imediato do tratamento.

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
·Pré-clínico17
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 17 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Síndrome de encarceramento

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

🟢 Recrutando agora

6 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

Outros ensaios clínicos

21 ensaios clínicos encontrados, 8 ativos.

Distribuição por fase
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
323 papers (10 anos)
#1

Advancing the science of consciousness: From ethics to clinical care.

Neuroscience and biobehavioral reviews2026 Jan

Significant advances in the scientific investigation of the neurobiology of consciousness have been slow to be translated into clinical settings, limited by a lack of generally agreed working definition (e.g., what is consciousness?) and methodology (e.g., how to identify reliable biomarkers/indicators of consciousness? How to improve sensitivity and specificity of the technological identification of consciousness?). In the present paper we aim at proposing potential strategies for reducing the gap between research, clinical practice, and patients' and their caregivers' needs regarding disorders of consciousness. By implementing a multidisciplinary (i.e., involving different disciplines) and multiperspective (i.e., involving different stakeholders) approach, the paper focuses on disorders of consciousness: it starts from the review of some of the most promising measures of consciousness from brain activity (i.e., electrophysiology and spectral measures, measures of functional connectivity, complexity-based measures). Next the paper introduces brain responses to illusions as a possible new indicator of consciousness (i.e., a feature that facilitates the attribution of consciousness), and illustrates a possible clinical operationalization of the indicators of consciousness through the case of virtual reality. Finally, the paper analyses a set of urgent ethical issues and describes a model for assessing and dealing with those issues, concluding by elaborating key recommendations for improving the clinical treatment of patients with disorders of consciousness through a better translation of research into clinics.

#2

Large-scale training data enhances silent speech decoding with around-ear EEG.

Journal of neural engineering2026 Mar 19

&#xD; Silent speech decoding (SSD) offers a potential communication alternative for individuals with impaired vocalization. However, conventional multi-electrode electroencephalography (EEG) or facial electromyography (EMG) systems require cumbersome preparation and are unsuitable for daily use. This study evaluates the practicality of SSD using a wearable around-ear EEG device, focusing on data scaling, cross-subject transfer, vocabulary extensibility, and online decoding performance.&#xD;Approach.&#xD; We collected 72 hours of around-ear EEG from 24 healthy participants and one individual with incomplete locked-in syndrome (LIS) during silent, vocalized, and attempted speech, and integrated these around-ear EEG recordings with prior EMG + high-density EEG datasets, yielding 282.4 total hours of training data. Using a 64-word classification task as the evaluation metric, we assessed: (1) whether larger datasets improve around-ear EEG-based SSD, (2) whether healthy-participant data supplement limited LIS-participant data despite articulatory differences, (3) transferability to unseen vocabulary, and (4) online user-interface performance.&#xD;Main results.&#xD; Large-scale EEG/EMG data improved SSD accuracy in both healthy participants and the LIS participant. Training on the heterogeneous dataset achieved 56.6% accuracy for healthy users and 47.3% for the LIS participant. Fine-tuning this decoder for new vocabulary increased the accuracy by 22 percentage points relative to training from scratch. Regression analysis showed that, for decoding in the LIS participant, data from the LIS participant contributed approximately four times the weight of healthy-participant data, quantifying data strategies for SSD. Online experiments achieved top-1/top-5 accuracies of 47.2%/76.0% for healthy users and 26.5%/49.1% for the LIS participant.&#xD;Significance.&#xD; The results indicate that lightweight, commercially feasible around-ear EEG can enable practical SSD when combined with large-scale healthy-participant data, supporting online operation. Moreover, models trained on a 64-word vocabulary facilitate decoding of a new vocabulary, providing a path toward SSD systems requiring minimal LIS-participant data. This study advances non-invasive silent speech decoding systems suitable for everyday communication.

#3

A visual imagery paradigm for BCI strategies using imagined flickering patterns.

Scientific reports2026 Mar 04

Steady state visually evoked potentials (SSVEPs) are a popular type of control signals in brain-computer interfaces (BCIs), in which they are typically elicited by observing a visual stimulus flashing at a specific frequency. For some patients, using SSVEP as control signal for a BCI can be difficult, for instance if they are unable to focus their gaze over the visual stimuli. To address this issue, some approaches were presented to design a gaze-independent SSVEP-controlled BCI but some difficulties have been reported, for instance for patients suffering from locked-in syndrome. In this work we employ a visual imagery (VI) signal, in which the visual stimulus is imagined instead of observed, to drive a BCI system and offer an alternative for patients that encounter issues with standard SSVEP approaches. We tested the proposed approach with 20 untrained subjects within a 3-classes BCI resulting in an offline classification accuracy of 60.93%. These results demonstrate how this gaze-independent BCI can be used by inexperienced BCI users.

#4

Implantable Neural Speech Decoders: Recent Advances, Future Challenges.

Neurorehabilitation and neural repair2026 Feb

The social life of locked-in syndrome (LIS) patients is significantly impacted by their difficulties to communicate. Consequently, researchers have started to explore how to decode intended speech from neural signals directly recorded from the cortex. The first studies in the late 2000s reported modest decoding accuracies. However, thanks to fast advances in machine learning, the most recent studies have reached decoding accuracies high enough to be optimistic about the clinical benefit of neural speech decoders in the near future. We first discuss the selection criteria for implanting a neural speech decoder in LIS patients, emphasizing the advantages and disadvantages associated with conditions such as brainstem stroke and amyotrophic lateral sclerosis. We examine the key design considerations for neural speech decoders, demonstrating how successful implantation requires careful optimization of multiple interrelated factors including language representation, cortical recording areas, neural features, training paradigms, and decoding algorithms. We then discuss current approaches and provide arguments for potential improvements in decoder design and implementation. Finally, we explore the crucial question of who should learn to use the neural speech decoder-the patient, the machine, or both. In conclusion, while neural speech decoders present promising avenues for improving communication for LIS patients, interdisciplinary efforts spanning neurorehabilitation, neuroscience, neuroengineering, and ethics are imperative to design future clinical trials.

#5

Central pontine myelinolysis in diffuse large B-cell lymphoma, a case series and literature review.

BMC neurology2025 Dec 04

Diffuse large B-cell lymphoma is the most common type of non-Hodgkin lymphoma in Saudi Arabia. Osmotic demyelination syndrome (ODS) is divided into central pontine myelinolysis (CPM) and extrapontine myelinolysis. The occurrence of osmotic demyelination syndrome is classically described in the setting of rapid correction of hyponatremia. Clinical Manifestations are variable, ranging from asymptomatic cases to quadriparesis and locked-in syndrome in the severe form. We reported a total of six cases with diffuse large B-cell lymphoma (DLBCL) that developed central pontine myelinolysis. A literature review was done reviewing all case reports of central pontine myelinolysis occurring in patients with non-Hodgkin lymphoma. A total of 16 patients were reviewed, including our six cases and ten patients from published reports. Nine out of 16 were asymptomatic (56.3%), and DLBCL was present in all cases except one (93.8%). Risk factors such as fluctuations in osmolality or hypoalbuminemia were documented in 9 out of the 16 cases (65.3%), and none had undergone overly rapid sodium correction. The outcome was favorable in all cases, with no residual neurological deficits. DLBCL can predispose to pontine changes suggestive of CPM with a relatively favorable prognosis. The nature of these changes remains uncertain due to lack of histopathological confirmation.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC493 artigos no totalmostrando 194

2026

Large-scale training data enhances silent speech decoding with around-ear EEG.

Journal of neural engineering
2026

A visual imagery paradigm for BCI strategies using imagined flickering patterns.

Scientific reports
2025

Brain-computer interfaces: a new horizon in communication for locked-in syndrome.

Annals of medicine and surgery (2012)
2025

Central pontine myelinolysis in diffuse large B-cell lymphoma, a case series and literature review.

BMC neurology
2025

Consensus on covert awareness: a Delphi study.

Brain communications
2025

Harmonic Component Analysis: A novel training-free and asynchronous BCI classification method.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
2025

A Novel Approach to Improve SSVEP-BCI Performance Through Neurofeedback Training.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
2025

Empowering Accessibility: Human-Centered Approach to a BCI Home Control for Impaired People.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
2026

Advancing the science of consciousness: From ethics to clinical care.

Neuroscience and biobehavioral reviews
2025

Disorder of consciousness rather than complete Locked-In Syndrome for end stage Amyotrophic Lateral Sclerosis: a case series.

Communications medicine
2025

Assessing consciousness in patients with locked-in syndrome using their EEG.

Frontiers in neuroscience
2025

Covert consciousness: what's in a name?

Brain : a journal of neurology
2025

Real-time detection of spoken speech from unlabeled ECoG signals: a pilot study with an ALS participant.

Journal of neural engineering
2026

Implantable Neural Speech Decoders: Recent Advances, Future Challenges.

Neurorehabilitation and neural repair
2025

Assessing Capacity and Exploring Goals of Care in Locked-In Syndrome: A Clinician's Guide.

Neurology. Clinical practice
2025

Jahi McMath case: A comprehensive and updated narrative.

World journal of critical care medicine
2025

Decoding intended speech with an intracortical brain-computer interface in a person with longstanding anarthria and locked-in syndrome.

bioRxiv : the preprint server for biology
2025

Don't put words in my mouth: speech perception can falsely activate a brain-computer interface.

Journal of neuroengineering and rehabilitation
2025

Legal personhood and legal capacity: the case of the locked-in syndrome.

Journal of law and the biosciences
2025

Catatonia: American Psychiatric Association Resource Document.

Journal of the Academy of Consultation-Liaison Psychiatry
2025

The effectiveness of FOUR score versus GCS scale in predicting mortality and morbidity in traumatic brain injured patients in intensive care: A systematic review.

Intensive &amp; critical care nursing
2025

Impact of communication modalities on autonomy and social participation of persons with locked-in syndrome.

Brain impairment : a multidisciplinary journal of the Australian Society for the Study of Brain Impairment
2025

Simulating online and offline tasks using hybrid cheetah optimization algorithm for patients affected by neurodegenerative diseases.

Scientific reports
2025

Bilateral medial medullary and spinal cord infarctions presenting as locked-in syndrome in an adolescent with primary antiphospholipid syndrome.

BMJ case reports
2025

Designing an online BCI forum: insights from researchers and end-users.

Journal of neural engineering
2025

Pan-neurofascin autoimmune nodoparanodopathy: A case report and literature review.

Medicine
2024

A novel non-invasive EEG-SSVEP diagnostic tool for color vision deficiency in individuals with locked-in syndrome.

Frontiers in bioengineering and biotechnology
2025

Decoding speech intent from non-frontal cortical areas.

Journal of neural engineering
2025

RSVP keyboard with inquiry preview: mixed performance and user experience with an adaptive, multimodal typing interface combining EEG and switch input.

Journal of neural engineering
2024

Good results of neurorehabilitation of ischaemic stroke - locked-in syndrome in a pregnant woman with delivery of healthy child.

Neurologia i neurochirurgia polska
2024

Predicting attentional focus: Heartbeat-evoked responses and brain dynamics during interoceptive and exteroceptive processing.

PNAS nexus
2025

A Case of Guillain-Barré Syndrome and Repurposing cEEG to Enable Communication in Total Locked-in Syndrome.

Neurocritical care
2024

Brain Function and Structure Changes in the Prognosis Prediction of Prolonged Disorders of Consciousness.

Brain topography
2024

From locked-in syndrome to recovery: thrombolysis success in bilateral pontine infarction with 'heart appearance' sign.

BMJ case reports
2024

[Diagnosis, Notification, and Managements of ALS: A Personal Perspective from 40 years of Experience as a Clinical Neurologist].

Brain and nerve = Shinkei kenkyu no shinpo
2024

DO NOT LOSE SLEEP OVER IT: IMPLANTED BRAIN-COMPUTER INTERFACE FUNCTIONALITY DURING NIGHTTIME IN LATE-STAGE AMYOTROPHIC LATERAL SCLEROSIS.

medRxiv : the preprint server for health sciences
2024

Brain-Computer Interfaces with Intracortical Implants for Motor and Communication Functions Compensation: Review of Recent Developments.

Sovremennye tekhnologii v meditsine
2024

Clinical and ethical challenges in decision-making for patients with disorders of consciousness and locked-in syndrome from Chinese neurologists' perspectives.

Therapeutic advances in neurological disorders
2024

Withdrawal of Life-Sustaining Mechanical Ventilation for a Patient With Amyotrophic Lateral Sclerosis in Locked-In Syndrome.

Journal of clinical neurology (Seoul, Korea)
2024

Iterative alignment discovery of speech-associated neural activity.

Journal of neural engineering
2024

Locked-in Syndrome Due to Isolated Basilar Artery Dissection.

Radiology
2024

Dilemma in patients with amyotrophic lateral sclerosis and expectations from brain-machine interfaces.

Annals of medicine
2024

Locked-in syndrome: A qualitative study of a life story.

Brain and behavior
2024

A review on the performance of brain-computer interface systems used for patients with locked-in and completely locked-in syndrome.

Cognitive neurodynamics
2024

[Recovery from locked-in syndrome: rule rather than exception].

Nederlands tijdschrift voor geneeskunde
2024

Rapidly progressive locked-in syndrome secondary to atypical herpes simplex virus-1 rhombencephalitis in an immunocompromised individual.

IDCases
2024

Locked-In Syndrome: A Rare Manifestation of Neuropsychiatric Lupus.

Cureus
2024

High Doses of Caffeine-Induced Cerebral Infarction Leading to Partial Locked-In Syndrome in a Young Adult: A Novel Association?

Case reports in neurology
2024

The ethical significance of user-control in AI-driven speech-BCIs: a narrative review.

Frontiers in human neuroscience
2024

Locked-in Syndrome After Pontine Hemorrhage in an Amphetamine Abuser.

Deutsches Arzteblatt international
2024

Correcting for ERP latency jitter improves gaze-independent BCI decoding.

Journal of neural engineering
2024

Facile Electret-Based Self-Powered Soft Sensor for Noncontact Positioning and Information Translation.

ACS applied materials &amp; interfaces
2024

Brain-to-brain interface technology: A brief history, current state, and future goals.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience
2024

Locked-in syndrome following elective cervical foraminotomy: a case report.

Spinal cord series and cases
2024

Neural signatures of imaginary motivational states: desire for music, movement and social play.

Brain topography
2024

Developer perspectives on the ethics of AI-driven neural implants: a qualitative study.

Scientific reports
2024

Transient Locked-in Syndrome after Aneurysmal Subarachnoid Bleeding due to Spasm Hypoxemia?

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine
2024

[Listeria meningoencephalitis resulting in complete bilateral ophtalmoplegia and locked-in syndrome].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
2024

A scoping review of gaze and eye tracking-based control methods for assistive robotic arms.

Frontiers in robotics and AI
2024

Anesthetic Considerations for Patients with Locked-In Syndrome Undergoing Endoscopic Procedures.

The American journal of case reports
2024

Locked-in syndrome after central pontine myelinolysis, an outstanding outcome of two patients.

Annals of clinical and translational neurology
2024

[‘Locked-in syndrome’ in Norwegian].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke
2024

Update on How to Approach a Patient with Locked-In Syndrome and Their Communication Ability.

Brain sciences
2024

The challenge of controlling an auditory BCI in the case of severe motor disability.

Journal of neuroengineering and rehabilitation
2023

A Brain-Controlled Quadruped Robot: A Proof-of-Concept Demonstration.

Sensors (Basel, Switzerland)
2024

Severe osmotic demyelination syndrome with cortical involvement in the context of severe hyponatremia and central diabetes insipidus: an uncommon presentation of an unusual combination.

BMJ case reports
2023

Anti-GQ1b Antibody Syndrome Presented as Locked-In Syndrome: A Rare Case Report.

Cureus
2023

The vascular locked-in and locked-in-plus syndrome: A retrospective case series.

Therapeutic advances in neurological disorders
2023

Atypical Presentation of the Classical Form of Locked-In Syndrome in a Young Patient.

Journal of investigative medicine high impact case reports
2023

Boosting brain-computer interfaces with functional electrical stimulation: potential applications in people with locked-in syndrome.

Journal of neuroengineering and rehabilitation
2023

Communication board in locked-in syndrome: a practical interaction method with the patient.

Dementia &amp; neuropsychologia
2023

Osmotic Demyelination Syndrome: A Rare Clinical Image.

Diagnostics (Basel, Switzerland)
2023

It takes two (seconds): decreasing encoding time for two-choice functional near-infrared spectroscopy brain-computer interface communication.

Neurophotonics
2022

Neuroscience of consciousness in the locked-in syndrome: Prognostic and diagnostic review.

Ibrain
2023

Massive body-brain disconnection consequent to spinal cord injuries drives profound changes in higher-order cognitive and emotional functions: A PRISMA scoping review.

Neuroscience and biobehavioral reviews
2023

Using fMRI to localize target regions for implanted brain-computer interfaces in locked-in syndrome.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
2023

Moral Uncertainty and Our Relationships with Unknown Minds.

Cambridge quarterly of healthcare ethics : CQ : the international journal of healthcare ethics committees
2023

Altered brain dynamics index levels of arousal in complete locked-in syndrome.

Communications biology
2024

Brain-Computer Interfaces, Completely Locked-In State in Neurodegenerative Diseases, and End-of-Life Decisions.

Journal of bioethical inquiry
2023

Assessing consciousness in patients with disorders of consciousness using soft-clustering.

Brain informatics
2023

Demographic, Medical, and Clinical Characteristics of a Population-Based Sample of Patients With Long-lasting Locked-In Syndrome.

Neurology
2023

Locked-in syndrome caused by extracranial and intracranial takayasu arteritis: A rare case report and radiological findings.

Radiology case reports
2023

Multidimensional assessment of heartbeat-evoked responses in disorders of consciousness.

The European journal of neuroscience
2023

Rapid Correction of Hyponatremia With Isotonic Saline Leading to Central Pontine Myelinolysis.

Cureus
2023

Heroin-Induced Leukoencephalopathy Leading to Locked-In Syndrome: A Case Report.

Cureus
2023

Assessment and management of pain/nociception in patients with disorders of consciousness or locked-in syndrome: A narrative review.

Frontiers in systems neuroscience
2023

Locked-in syndrome revisited.

Therapeutic advances in neurological disorders
2023

Religiosity in patients with amyotrophic lateral sclerosis, a cross-country comparison.

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
2023

Understanding the Psychological Well-being of Patients With Locked-in Syndrome: A Scoping Review.

Cureus
2023

Central pontine myelinolysis and locked-IN syndrome associated with tacrolimus after pediatric heart transplantation.

Pediatric transplantation
2022

Application of Soft-Clustering to Assess Consciousness in a CLIS Patient.

Brain sciences
2022

Event-related brain potential markers of visual and auditory perception: A useful tool for brain computer interface systems.

Frontiers in behavioral neuroscience
2022

[Let's Watch the Movie, The Diving Bell and the Butterfly and Think About the Patient's Feelings].

Brain and nerve = Shinkei kenkyu no shinpo
2022

Subacute brainstem ischemic syndrome in juvenile neurofibromatosis type 2: An underrecognized condition.

Clinical case reports
2022

Writing Blindly in Incomplete Locked-In Syndrome with A Custom-Made Switch-Operated Voice-Scanning Communicator-A Case Report.

Brain sciences
2022

Development of Parkinsonism in a Patient with Central Pontine Myelinolysis.

Neurology international
2022

Methodological Recommendations for Studies on the Daily Life Implementation of Implantable Communication-Brain-Computer Interfaces for Individuals With Locked-in Syndrome.

Neurorehabilitation and neural repair
2022

A 44-Year-Old Alcohol-Dependent Man Who Recovered from Central Pontine Myelinolysis with Supportive Physical Therapy.

The American journal of case reports
2022

Slow Firing Single Units Are Essential for Optimal Decoding of Silent Speech.

Frontiers in human neuroscience
2023

Locked-in syndrome responding to endovascular treatment.

Journal of neurointerventional surgery
2022

A systematic review of research on augmentative and alternative communication brain-computer interface systems for individuals with disabilities.

Frontiers in human neuroscience
2022

Towards predicting ECoG-BCI performance: assessing the potential of scalp-EEG.

Journal of neural engineering
2022

Acute vertical pendular nystagmus: eye-movement analysis and review of the literature.

Journal of neurology
2022

The locked-in syndrome: The early French descriptions.

Revue neurologique
2022

Optimizing Motor Imagery Parameters for Robotic Arm Control by Brain-Computer Interface.

Brain sciences
2022

Posttraumatic locked-in syndrome from combined brainstem and upper cervical injury in childhood: A case report.

Neuro-Chirurgie
2023

Who gets to decide?: Substitute decision making following severe brain injury with communication impairment.

Neuropsychological rehabilitation
2022

A unique case of free-floating gastric band tubing causing intraabdominal sepsis in a patient with locked-in syndrome secondary to Guillain-Barré syndrome.

Journal of surgical case reports
2022

French Survey on Pain Perception and Management in Patients with Locked-In Syndrome.

Diagnostics (Basel, Switzerland)
2022

Dramatic neuromuscular paralysis following occult snakebites: An awareness for the primary care physician.

Journal of family medicine and primary care
2022

Mechanical thrombectomy via chronic occluded proximal artery for the endovascular treatment of acute ischemic stroke patients with large vessel occlusion.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
2022

Investigating Structure-Function Connectivity in a Patient With Locked-In Syndrome by 7 T Magnetic Resonance Imaging: A Case Report.

The neurologist
2022

Brain-Computer Interface: Applications to Speech Decoding and Synthesis to Augment Communication.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
2021

Snakebite Mimicking Brain Death: Bedside Clues.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine
2021

See, Hear, or Feel - to Speak: A Versatile Multiple-Choice Functional Near-Infrared Spectroscopy-Brain-Computer Interface Feasible With Visual, Auditory, or Tactile Instructions.

Frontiers in human neuroscience
2021

Control and Ownership of Neuroprosthetic Speech.

Philosophy &amp; technology
2022

Locked-in Syndrome Due to Meningovascular Syphilis: A Case Report and Literature Review.

Internal medicine (Tokyo, Japan)
2021

Decoding four hand gestures with a single bipolar pair of electrocorticography electrodes.

Journal of neural engineering
2021

Locked-In Syndrome: A Systematic Review of Long-Term Management and Prognosis.

Cureus
2023

Brain-Computer interfaces for communication: preferences of individuals with locked-in syndrome, caregivers and researchers.

Disability and rehabilitation. Assistive technology
2020

Locked-In Syndrome after Traumatic Basilar Artery Entrapment within a Clivus Fracture: A Case Report and Review of the Literature.

Neurotrauma reports
2021

Probable first report of a motor deafferentation syndrome in the Paraguayan War.

Arquivos de neuro-psiquiatria
2021

A Case of Central Pontine Myelinolysis Occurred During Treatment of Hyperosmolar Hyperglycemic Syndrome.

International medical case reports journal
2022

The clinical and cognitive spectrum of locked-in syndrome: 1-year follow-up of 100 patients.

Acta neurologica Belgica
2022

Thinking without speaking: Neuropsychological testing with individuals who have communication impairments.

Neuropsychological rehabilitation
2021

[Hikikomori and locked-in syndrome].

Medicina
2021

Isolated basilar artery dissection following blunt trauma challenging the Glasgow coma score: A case report.

The American journal of emergency medicine
2021

Neurophysiological aspects of the completely locked-in syndrome in patients with advanced amyotrophic lateral sclerosis.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
2021

Transient total locked-in syndrome due to vertebral and basilar artery dissection.

BMJ case reports
2021

A clinical characteristic analysis of five cases of rare bilateral cerebral peduncular infarction (BCPI) with the 'Mickey Mouse ears' sign.

Brain injury
2021

Brain-Computer Interfaces for Communication: Preferences of Individuals With Locked-in Syndrome.

Neurorehabilitation and neural repair
2020

Corrigendum: Performance Differences Using a Vibro-Tactile P300 BCI in LIS-Patients Diagnosed With Stroke and ALS.

Frontiers in neuroscience
2021

Locked-In Syndrome: Practical Rehabilitation Management.

PM &amp; R : the journal of injury, function, and rehabilitation
2021

The multiplicity of caregiving burden: a qualitative analysis of families with prolonged disorders of consciousness.

Brain injury
2020

Consciousness Detection in a Complete Locked-in Syndrome Patient through Multiscale Approach Analysis.

Entropy (Basel, Switzerland)
2020

False-Negative Initial Magnetic Resonance Imaging in Acute Posterior Circulation Stroke: A Case Report Describing Locked-in Syndrome.

Cureus
2021

Isolated Bilateral Cerebral Peduncular Infarction Manifesting Pseudobulbar Palsy and Quadriparesis: a Case Report.

Brain &amp; NeuroRehabilitation
2021

Are intrinsic neural timescales related to sensory processing? Evidence from abnormal behavioral states.

NeuroImage
2020

Locked-in Syndrome in a Young Patient Due to SARS-CoV-2: A Case Report.

Frontiers in medicine
2021

Severe Locked-In-Like Guillain-Barré's Syndrome: Dilemmas in Diagnosis and Treatment.

Neuropediatrics
2023

Diffuse cerebral angiomatosis associated to basilar apex aneurysm.

British journal of neurosurgery
2020

Electrophysiological and Neuroimaging Studies - During Resting State and Sensory Stimulation in Disorders of Consciousness: A Review.

Frontiers in neuroscience
2020

Test-Retest Reliability of Time-Domain EEG Features to Assess Cognitive Load Using a Wireless Dry-Electrode System.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
2020

Dorsolateral prefrontal cortex-based control with an implanted brain-computer interface.

Scientific reports
2022

"Re-identifying yourself": a qualitative study of veteran views on implantable BCI for mobility and communication in ALS.

Disability and rehabilitation. Assistive technology
2020

Recurrent Vertebrobasilar Strokes Associated With Acute Posterior Multifocal Placoid Pigment Epitheliopathy (APMPPE).

The neurologist
2020

Dramatic Response to Pramipexole in Delayed-Onset Parkinsonism from Osmotic Demyelinating Syndrome.

Tremor and other hyperkinetic movements (New York, N.Y.)
2020

A Case Report of Basilar Artery Occlusion in a Healthy 36-Year-Old Female.

Cureus
2020

Prefrontal cortex transcranial direct-current stimulation putatively enhances electroencephalography classification resolution of binary responses in a minimal conscious state patient.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
2020

Stimulus modality influences session-to-session transfer of training effects in auditory and tactile streaming-based P300 brain-computer interfaces.

Scientific reports
2020

Functional Near-Infrared Spectroscopy in the Study of Speech and Language Impairment Across the Life Span: A Systematic Review.

American journal of speech-language pathology
2020

Chronic encephalopathy and locked-in state due to scrub typhus related CNS vasculitis.

Journal of neuroimmunology
2020

The current state of electrocorticography-based brain-computer interfaces.

Neurosurgical focus
2020

Recovery from prolonged disorders of consciousness: A dual-center prospective cohort study in China.

World journal of clinical cases
2020

Acute polyradiculoneuritis with locked-in syndrome in a patient with Covid-19.

Journal of neurology
2020

Histological Confirmation of Myelinated Neural Filaments Within the Tip of the Neurotrophic Electrode After a Decade of Neural Recordings.

Frontiers in human neuroscience
2021

Decoding overt shifts of attention in depth through pupillary and cortical frequency tagging.

Journal of neural engineering
2019

Therapeutic Approaches in Locked-in Syndrome.

Folia medica
2020

Effects of a Vibro-Tactile P300 Based Brain-Computer Interface on the Coma Recovery Scale-Revised in Patients With Disorders of Consciousness.

Frontiers in neuroscience
2020

Decoding Imagined and Spoken Phrases From Non-invasive Neural (MEG) Signals.

Frontiers in neuroscience
2020

Brain-computer interfaces for communication.

Handbook of clinical neurology
2020

Brain-computer interfaces for consciousness assessment and communication in severely brain-injured patients.

Handbook of clinical neurology
2020

Medullary Infarction Leading to Locked-In Syndrome Following Lumbar Puncture in a Patient with Basilar Invagination.

World neurosurgery
2019

'Without A Key': A Classroom Case Study.

Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience
2020

Basilar artery thrombosis during sexual intercourse.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
2020

Electroencephalogram based communication system for locked in state person using mentally spelled tasks with optimized network model.

Artificial intelligence in medicine
2020

Optimized artificial neural network based performance analysis of wheelchair movement for ALS patients.

Artificial intelligence in medicine
2019

Decoding Speech from Single Trial MEG Signals Using Convolutional Neural Networks and Transfer Learning.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
2020

Toward Improving Diagnostic Strategies in Chronic Disorders of Consciousness: An Overview on the (Re-)Emergent Role of Neurophysiology.

Brain sciences
2019

Topographic Somatosensory Imagery for Real-Time fMRI Brain-Computer Interfacing.

Frontiers in human neuroscience
2019

[Locked-in Syndrome due to Primary Brainstem Injury:A Case Report].

No shinkei geka. Neurological surgery
2020

Transcranial direct current stimulation for a patient with locked-in syndrome.

Brain stimulation
2019

Determining the Optimal Number of MEG Trials: A Machine Learning and Speech Decoding Perspective.

Brain informatics : international conference, BI 2018, Arlington, TX, USA, December 7-9, 2018, proceedings. International Conference on Brain Informatics (2018 : Arlington, Tex.)
2019

Cocaine as a rare cause of locked-in syndrome: a case report.

Journal of medical case reports
2019

An Analysis of Clinical Characteristics of Rare Bilateral Cerebral Peduncular Infarction.

Frontiers in neurology
2020

Ethics of life-sustaining treatment in locked-in syndrome: A Chinese survey.

Annals of physical and rehabilitation medicine
2019

Sensorimotor ECoG Signal Features for BCI Control: A Comparison Between People With Locked-In Syndrome and Able-Bodied Controls.

Frontiers in neuroscience
2019

Sleep in the completely locked-in state (CLIS) in amyotrophic lateral sclerosis.

Sleep
2021

Hyperhomocysteinemia induced locked-in syndrome in a young adult due to folic acid deficiency.

Nutritional neuroscience
2019

Smog Sign: Hazy Diffusion-weighted Imaging Restriction in Dense Axonal Tracts in the Pons on Hyperacute MRI with Remarkable Clinical Improvement After Intra-arterial Thrombectomy.

Cureus
2019

Basilar Artery Occlusion: Diagnosis and Acute Treatment.

Current treatment options in neurology
2019

Disorders of consciousness terminology: history, evolution and future directions.

Brain injury
2019

Neuroprosthetic Speech: The Ethical Significance of Accuracy, Control and Pragmatics.

Cambridge quarterly of healthcare ethics : CQ : the international journal of healthcare ethics committees
2019

Anti-pan-neurofascin IgG3 as a marker of fulminant autoimmune neuropathy.

Neurology(R) neuroimmunology &amp; neuroinflammation
2019

God locked you in the room, but left a window open: A case report of spinal cord stimulation in locked-in syndrome.

Brain stimulation
2019

Locked-In Syndrome Following Cervical Manipulation by a Chiropractor: A Case Report.

Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures)
2019

Rethinking the locked-in state for people with ALS.

Neurology
2019

Leveraging Nonhuman Primate Multisensory Neurons and Circuits in Assessing Consciousness Theory.

The Journal of neuroscience : the official journal of the Society for Neuroscience
2019

Decerebrate rigidity with preservation of consciousness in pontine hemorrhage with complete neurologic recovery.

Neurology India
2019

Alpha oscillations and consciousness in completely locked-in state.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
2019

Late recovery of responsiveness after intra-thecal baclofen pump implantation and the role of diffuse pain and severe spasticity: a case report.

Acta neurochirurgica
2019

Single-paradigm and hybrid brain computing interfaces and their use by disabled patients.

Journal of neural engineering
2019

Semantic and BCI-performance in completely paralyzed patients: Possibility of language attrition in completely locked in syndrome.

Brain and language
2019

Automated pupillometry to detect command following in neurological patients: a proof-of-concept study.

PeerJ
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Doenças relacionadas

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Advancing the science of consciousness: From ethics to clinical care.
    Neuroscience and biobehavioral reviews· 2026· PMID 41319843mais citado
  2. Large-scale training data enhances silent speech decoding with around-ear EEG.
    Journal of neural engineering· 2026· PMID 41855656mais citado
  3. A visual imagery paradigm for BCI strategies using imagined flickering patterns.
    Scientific reports· 2026· PMID 41781440mais citado
  4. Implantable Neural Speech Decoders: Recent Advances, Future Challenges.
    Neurorehabilitation and neural repair· 2026· PMID 40960388mais citado
  5. Central pontine myelinolysis in diffuse large B-cell lymphoma, a case series and literature review.
    BMC neurology· 2025· PMID 41345567mais citado
  6. Decoding intended speech with an intracortical brain-computer interface in a person with long-standing anarthria and locked-in syndrome.
    Cell Rep· 2026· PMID 41920737recente
  7. Locked-in syndrome.
    Handb Clin Neurol· 2026· PMID 41896021recente
  8. Brainstem control of sleep, wakefulness, alertness, and consciousness.
    Handb Clin Neurol· 2026· PMID 41896020recente
  9. Brain death and the brainstem.
    Handb Clin Neurol· 2026· PMID 41896017recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:2406(Orphanet)
  2. MONDO:0016567(MONDO)
  3. GARD:6919(GARD (NIH))
  4. Busca completa no PubMed(PubMed)
  5. Artigo Wikipedia(Wikipedia)
  6. Q794457(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Síndrome de encarceramento
Compêndio · Raras BR

Síndrome de encarceramento

ORPHA:2406 · MONDO:0016567
🇧🇷 Brasil SUS
Triagem
qPCR para deleção de SMN1 em sangue seco
PNTN
Fase 5
Incidência BR
1:10.000
Geral
Prevalência
<1 / 1 000 000
Casos
33 casos conhecidos
Herança
Not applicable
CID-10
G83.8 · Outras síndromes paralíticas especificadas
CID-11
Ensaios
8 ativos
Início
All ages
Prevalência
0.0 (Worldwide)
MedGen
UMLS
C0023944
EuropePMC
Wikidata
Wikipedia
Papers 10a
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