Síndrome de paralisia supranuclear progressiva atípica

The Swedish BioFINDER 2 Study

NCT03174938

RECRUTANDO

The NADAPT Study: a Randomized Double-blind Trial of NAD Replenishment Therapy for Atypical Parkinsonism

NCT06162013

RECRUTANDO

Utilisation of Health Services and Quality of Life in Patients With Atypical Parkinsonian Syndromes

NCT06645626

RECRUTANDO

A Pilot Study to Explore the Role of Gut Flora in Parkinson's Disease

NCT04148326

DESCONHECIDO

AMX0035 and Progressive Supranuclear Palsy

NCT06122662

EM ANDAMENTO

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0 papers (10 anos)

#1

Chronological Diagnostic Algorithm Predicting Neuropathology in Parkinsonism.

Annals of neurology2026 Mar 14

Pre-mortem diagnosis of parkinsonism is often challenging due to atypical presentations, overlapping syndromes, and co-pathologies. This study aimed to develop a machine learning-based algorithm predicting neuropathology in parkinsonism using chronological clinical presentations, which has previously been underexplored. Clinical information was automatically abstracted from medical records of the Mayo Clinic Brain Bank using fine-tuned Generative Pre-trained Transformer 4 models. Patients who developed parkinsonism within 3 years of disease onset were included. Six machine learning models were trained with age, sex, family history, and 197 clinical presentations paired with onset information to predict neuropathologic diagnoses, including co-pathologies. Among 7,825 donors, 949 met inclusion criteria, representing 9 neuropathologic categories: Lewy body disease (LBD; n = 128), LBD with Alzheimer's disease (AD; n = 136), progressive supranuclear palsy (PSP; n = 303), PSP with AD (n = 56), PSP with LBD (n = 27), multiple system atrophy (MSA; n = 120), corticobasal degeneration (CBD; n = 99), AD (n = 43), and frontotemporal lobar degeneration (FTLD; n = 37). The CatBoost algorithm achieved an area under the receiver operating characteristic curve of 0.83 across the 9 diagnostic categories at 3 years after onset. Important predictors included age at onset, restricted eye movement, and tremor. The model remained robust to incomplete data, requiring only 23 of 200 parameters for reliable predictions with an area under the curve of 0.80. The algorithm was implemented into a user-friendly program providing diagnostic probabilities with visualizations of parameter contributions. This neuropathology-confirmed diagnostic algorithm provides a cost-effective and interpretable screening tool for parkinsonism, bridging biomarker testing and molecular-targeted therapies. ANN NEUROL 2026.

#2

Early clinical characteristics of pathologically confirmed progressive supranuclear palsy and corticobasal degeneration.

Journal of neurology2026 Mar 11

Although the clinical features of progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are well documented, their early clinical presentations from the perspective of initial clinical consultation remain less well understood. This study aimed to characterize the early clinical features of PSP and CBD to inform clinicians on diagnostic assessment and management strategies. Data were obtained from the National Alzheimer's Coordinating Center (NACC) database (2005-March 2025 data freeze). Neuropathologically confirmed cases of PSP (n = 278) and CBD (n = 149) were included. Analyses were restricted to first clinical visits, focusing on demographic, neuropsychiatric, neurological, and neuropsychological variables. Memory symptoms were reported in more than half of both groups, whereas language impairment was more common in CBD (> 70%) and associated with higher odds of CBD diagnosis. Depression was frequent (~ 50%), with PSP showing higher odds for depressive symptoms but lower odds for disinhibition. Although 20-30% of both PSP and CBD patients exhibited no parkinsonian signs at presentation, gait disturbance, falls, and slowness were common and strongly associated with PSP. Approximately half of both groups presented with cognitive-predominant onset, and nearly one-fifth were initially misdiagnosed as Alzheimer's disease. A substantial proportion of PSP and CBD patients lack parkinsonian signs at first presentation, and cognitive-onset presentations are frequent, leading to early diagnostic uncertainty. Clinicians should recognize these overlapping features when evaluating early atypical parkinsonian or cognitive syndromes.

#3

Longitudinal Evaluation of Polyneuropathy in Atypical Parkinsonian Syndromes.

Neurology international2026 Feb 03

Background: In Parkinson's disease (PD), a higher prevalence of polyneuropathy (PNP) is increasingly recognized, although the causal association is still under debate. In contrast, PNP in atypical parkinsonian syndromes (APS) has been insufficiently addressed, despite preliminary evidence suggesting elevated prevalence. Methods: Nerve conduction studies were performed on 13 patients with multiple system atrophy (MSA) and 9 patients with progressive supranuclear palsy (PSP) at baseline. PNP was diagnosed according to standard electrophysiological criteria after exclusion of common secondary causes. Comprehensive clinical evaluation included motor and non-motor assessments over two years of follow-up. Results: At baseline, PNP was present in 53.8% of MSA patients and 66.7% of PSP patients. MSA patients with PNP showed greater motor symptom severity (UPDRS III score; p = 0.046) and worse cognitive performance (MoCA; p = 0.044) compared to those without PNP. Over two years, a significant reduction in the tibial nerve amplitude was observed exclusively in MSA patients (p = 0.039), paralleling disease progression. Conclusions: This study provides the first longitudinal evaluation of clinical and electrophysiological PNP progression in MSA and PSP. A high comorbidity of PNP in patients with APS could contribute to motor and sensory impairments in these patients. Our findings indicate that PNP progression may reflect disease progression in MSA. Given the limited sample size, larger-scale longitudinal studies are needed to further investigate biomarker potential of PNP in APS and to clarify differences in peripheral nerve involvement between synucleinopathies and tauopathies.

#4

Multi-model Diffusion MRI Signatures in Atypical Parkinsonian Disorders.

medRxiv : the preprint server for health sciences2026 Feb 05

Distinguishing atypical parkinsonian disorders (APS) from Parkinson's disease (PD) remains challenging due to overlapping clinical features, yet accurate differentiation is critical for prognosis and treatment. Here, we employed multi-model diffusion MRI (dMRI) analysis to characterize microstructural alterations across corticobasal syndrome (CBS), progressive supranuclear palsy-Richardson syndrome (PSP-RS) and PD, with the aim of identifying which dMRI model provides optimum differentiation. We analyzed 25 CBS, 42 PSP-RS, and 21 PD participants compared to 35 age and sex-matched controls. Using a clinically feasible 3-shell high angular resolution diffusion imaging (HARDI) protocol, we applied 11 metrics from five complementary dMRI models-diffusion tensor imaging (DTI), free-water-eliminated model of DTI (FWE), neurite orientation dispersion and density imaging (NODDI), tissue-weighted NODDI, and Fixel Density (FD) in fixel-based analysis (FBA) -to comprehensively assess regional white and gray matter integrity. Group differentiation was assessed using Cohen's d effect sizes and spearman correlations were assessed between dMRI metrics and clinical scales. Distinct microstructural signatures were observed across disorders and the sensitivity of the dMRI models differed. In group contrasts, DTI and NODDI-derived metrics consistently captured the strongest effects in midbrain and peduncular pathways for PSP-RS, whereas precentral and corticospinal alterations in CBS were most prominent using NODDI and FBA measures. Free-water-corrected metrics showed attenuated group differences. Across clinical-diffusion analyses, NODDI metrics exhibited the most robust associations with disease severity, while DTI and FWE measures detected more limited, regionally constrained effects. Together, these findings highlight complementary yet distinct sensitivities of tensor, free-water, multi-compartment, and fixel-based models to APS-related neurodegeneration.

#5

Neuroimaging and Pathology Biomarkers in Parkinson's Disease and Parkinsonism.

Brain sciences2026 Jan 19

The "Neuroimaging and Pathology Biomarkers in Parkinson's Disease" course held on 12-13 September 2025 in Milan, Italy, convened an international faculty to review state-of-the-art biomarkers spanning neurotransmitter dysfunction, protein pathology and clinical translation. Here, we synthesize the four themed sessions and highlights convergent messages for diagnosis, stratification and trial design. The first session focused on neuroimaging markers of neurotransmitter dysfunction, highlighting how positron emission tomography (PET), single photon emission computed tomography (SPECT), and magnetic resonance imaging (MRI) provided complementary insights into dopaminergic, noradrenergic, cholinergic and serotonergic dysfunction. The second session addressed in vivo imaging of protein pathology, presenting recent advances in PET ligands targeting α-synuclein, progress in four-repeat tau imaging for progressive supranuclear palsy and corticobasal syndromes, and the prognostic relevance of amyloid imaging in the context of mixed pathologies. Imaging of neuroinflammation captures inflammatory processes in vivo and helps study pathophysiological effects. The third session bridged pathology and disease mechanisms, covering the biology of α-synuclein and emerging therapeutic strategies, the clinical potential of seed amplification assays and skin biopsy, the impact of co-pathologies on disease expression, and the "brain-first" versus "body-first" model of pathological spread. Finally, the fourth session addressed disease progression and clinical translation, focusing on imaging predictors of phenoconversion from prodromal to clinically overt stages of synucleinopathies, concepts of neural reserve and compensation, imaging correlates of cognitive impairment, and MRI approaches for atypical parkinsonism. Biomarker-informed pharmacological, infusion-based, and surgical strategies, including network-guided and adaptive deep brain stimulation, were discussed as examples of how multimodal biomarkers may inform personalized management. Across all sessions, the need for harmonization, longitudinal validation, and pathology-confirmed outcome measures was consistently emphasized as essential for advancing biomarker qualification in multicentre research and clinical practice.

Publicações recentes

An autopsy case of progressive supranuclear palsy with severe corticospinal tract degeneration.

Neuropathology2024 Dec

Training high level balance and stepping responses in atypical progressive supranuclear palsy: a case report.

Physiother Theory Pract2023 May

Association Between Globular Glial Tauopathies and Frontotemporal Dementia-Expanding the Spectrum of Gliocentric Disorders: A Review.

JAMA Neurol2021 Aug 1

Typical or atypical progressive supranuclear palsy: a comparative clinicopathologic study of three Chinese cases.

Int J Clin Exp Pathol2015

A case of atypical progressive supranuclear palsy.

Clin Interv Aging2014

Ver todas no PubMed

📚 EuropePMCmostrando 200

Radiologie (Heidelberg, Germany)

[Basal ganglia and movement disorders : Part 1: the parkinsonian spectrum-Neuroradiological patterns and diagnostic considerations].

Chronological Diagnostic Algorithm Predicting Neuropathology in Parkinsonism.

Annals of neurology

Early clinical characteristics of pathologically confirmed progressive supranuclear palsy and corticobasal degeneration.

Improving access to care through transportation and internet use for patients with atypical parkinsonism: A pilot study.

Radiologie (Heidelberg, Germany)

[MRI in neurodegenerative Parkinsonian syndromes].

Longitudinal Evaluation of Polyneuropathy in Atypical Parkinsonian Syndromes.

Neurology international

A data-driven SSM/PCA analysis approach for differential diagnosis of parkinsonism using 11C-PE2I PET.

NeuroImage. Clinical

Journal of functional morphology and kinesiology

Juggling Under Controlled Hypoxia as a Multimodal Coordinative and Cognitive Training in Parkinson's Disease-A Narrative Review.

Cholinergic substrates of gait and postural impairments in Progressive Supranuclear Palsy.

Research square

medRxiv : the preprint server for health sciences

Multi-model Diffusion MRI Signatures in Atypical Parkinsonian Disorders.

The neuroradiology journal

Current Neuroimaging Modalities to Distinguish Parkinson's Disease from its Mimics: Imaging Features and Implications for Clinical Practice.

The New Zealand medical journal

Percutaneous endoscopic gastrostomy in atypical parkinsonian syndromes: survival and aspiration outcomes from a retrospective international cohort.

Retinal Thickness Profiles in Parkinsonian Syndromes: Discerning Parkinson's Disease, Multiple System Atrophy, and Progressive Supranuclear Palsy via Optical Coherence Tomography.

Biomedicines

Neuroimaging and Pathology Biomarkers in Parkinson's Disease and Parkinsonism.

Voice and Speech in Atypical Parkinsonian Disorders.

Oxford medical case reports

Paraneoplastic progressive Supranuclear palsy: a case report and literature review.

White matter hyperintensities in the deep cerebral venous territory differ between subcortical and cortical 4-repeat tauopathies.

Brain & NeuroRehabilitation

Clinical Framework for Motor Rehabilitation in Parkinsonism: Integrating Individualized and Syndrome-Specific Approaches.

NDPACX: a newly defined X-linked Parkinsonian syndrome associated with SLC9A6 hemizygote mutation.

Brain communications

Journal of neural transmission (Vienna, Austria : 1996)

Neurofilament light chain as a diagnostic and prognostic biomarker in atypical parkinsonisms: current evidence, new data, challenges, and future directions.

Richardson Syndrome Variant of Progressive Supranuclear Palsy: A Case Report.

Cureus

Cerebrospinal fluid biomarkers for diagnosis of Parkinson's disease: a systematic review and network meta-analysis.

Journal of neuroimaging : official journal of the American Society of Neuroimaging

Beyond Parkinson's Disease: A Narrative Review of Neuromelanin MRI in Neurodegenerative Diseases.

Annals of Indian Academy of Neurology

Interpeduncular Angle: A Possible Marker to Differentiate Atypical Parkinsonism from Idiopathic Parkinson's Disease.

Potential Role of Transferrin and Vascular Cell Adhesion Molecule 1 in Differential Diagnosis Among Patients with Tauopathic Atypical Parkinsonian Syndromes.

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine

Utility of Locus Coeruleus Signal Intensity on High-resolution T1-weighted MR Imaging with Magnetization Transfer for Differentiating Parkinson's Disease from Atypical Parkinsonism.

European journal of nuclear medicine and molecular imaging

Hybrid Tau-PET/MRI study: Quantitative susceptibility mapping in progressive supranuclear palsy and its correlation with Tau-PET.

European journal of neurology

Deceleration Capacity as a Marker of Autonomic Cardiac Modulation in Prodromal and Manifest Parkinson's Disease, Multiple System Atrophy, and Progressive Supranuclear Palsy.

Journal of the Formosan Medical Association = Taiwan yi zhi

Neuronal-specific antibody in patients with multiple system atrophy and progressive supranuclear palsy.

Toward Biology-Driven Diagnosis of Atypical Parkinsonian Disorders.

NeuroSci

No anti-IgLON5 antibody in carefully diagnosed PSP patients with "atypical" or variant clinical features.

Journal of neural transmission (Vienna, Austria : 1996)

Polyneuropathy in Parkinson's disease and atypical Parkinsonian syndromes: clinical impact and risk factors.

Journal of neural transmission (Vienna, Austria : 1996)

Cross-sectional and longitudinal validation of short and long versions of the progressive supranuclear palsy quality of life scale.

Patterns and causes of supranuclear vertical gaze palsy: A retrospective, single-institutional study in 113 patients.

Imaging of Proteinopathies in the Brains of Parkinsonian Disorders.

Cells

The Progressive Supranuclear Palsy Clinical Deficits Scale accurately reflects functional as well as patient- and caregiver-reported outcomes.

Quantitative Susceptibility Mapping and Iron Deposition in Autopsy-Confirmed Progressive Supranuclear Palsy.

A Review of FDG-PET in Progressive Supranuclear Palsy and Corticobasal Syndrome.

Midsagittal Midbrain Area and Midbrain-to-Pons-Ratio Cannot Distinguish Overlap Syndromes Between Amyotrophic Lateral Sclerosis and Progressive Supranuclear Palsy.

Clinical neuroradiology

Movement disorders : official journal of the Movement Disorder Society

Prevalence of NOTCH2NLC and FMR1 Repeat Expansions in Atypical Parkinsonism Compared to Asymptomatic Elderly Individuals.

Serious Illness Conversation in the Care of Atypical Parkinsonian Disorders: A Practical Guide for Neurology Clinicians.

Distinct microRNA signatures define sporadic PSP-RS and PD in patient-derived midbrain organoids.

iScience

Quantification of rehabilitation for patients with Parkinson's disease and related disorders using wearable devices; a proof of concept.

An Exploratory Analysis of Differential Tear Fluid miRNAs in Patients with Parkinson's Disease and Atypical Parkinsonian Syndromes.

Molecular neurobiology

Cognitive Decline in Parkinsonism: From Clinical Phenotypes to the Genetic Background.

Biomedicines

Acta neuropathologica communications

Frontotemporal Lobar degeneration with TDP-43 presenting as progressive supranuclear palsy syndrome.

Tau positron emission tomography in the Parkinson and Richardson subtypes of progressive supranuclear palsy.

Progression and natural history of Atypical Parkinsonism (ATPARK): Protocol for a longitudinal follow-up study from an underrepresented population.

PloS one

Spectral domain and angiography optical coherence tomography in atypical parkinsonisms and Parkinson disease: an explorative study.

Clinical neurology and neurosurgery

Pick's disease presenting as progressive apraxia of speech: Atypical clinical and neuroimaging features in three autopsy-confirmed cases.

Associations between neuropsychological profile and regional brain FDG uptake in progressive supranuclear palsy.

Journal of neural transmission (Vienna, Austria : 1996)

Fluid biomarkers in atypical Parkinsonism: current state and future perspectives.

European journal of human genetics : EJHG

A Spanish-Portuguese GWAS of progressive supranuclear palsy reveals a novel risk locus in NFASC.

The Genetic Background of the Immunological and Inflammatory Aspects of Progressive Supranuclear Palsy.

Movement disorders : official journal of the Movement Disorder Society

Neurophysiology of Atypical Parkinsonian Syndromes: A Study Group Position Paper.

Clinical Spectrum of Non-motor Symptoms in Correlation with Quality of Life in Parkinson's Disease and Atypical Parkinsonism: Evidence in Reaching Consensus.

Annals of neurosciences

Seminars in nuclear medicine

PET/CT in Movement Disorders: Update.

Magnetic Resonance Imaging in the Neuroimaging of Progressive Supranuclear Palsy-Parkinsonism Predominant: Limitations and Strengths in Clinical Evaluation.

Journal of neuroradiology = Journal de neuroradiologie

Concomitant progressive supranuclear palsy and multiple system atrophy: A rare case report of tauopathy and synucleinopathy interface.

Brain : a journal of neurology

Cognitive and neuropsychiatric profiles distinguish atypical parkinsonian syndromes.

The Significance of High-Density Lipoprotein-Derived Inflammatory Parameters in Atypical Parkinsonisms-Pilot Study.

Plasma miRNA Biomarker Signatures in Parkinsonian Syndromes.

Molecular neurobiology

Cerebrospinal fluid and blood neurofilament light chain in Parkinson's disease and atypical parkinsonian syndromes: a systematic review and Bayesian network meta-analysis.

Analysis of C9orf72 repeat length in progressive supranuclear palsy, corticobasal syndrome, corticobasal degeneration, and atypical parkinsonism.

Automated Imaging Differentiation for Parkinsonism.

JAMA neurology

Diseases (Basel, Switzerland)

The Spectrum of Cognitive Impairment in Atypical Parkinsonism Syndromes: A Comprehensive Review of Current Understanding and Research.

Journal of Alzheimer's disease : JAD

Autopsy-proven patient with corticobasal degeneration presenting with visuo-constructive disorders as initial symptoms: How advanced MRI sequences can help clinical practice.

Clinical prognostic factors in progressive supranuclear palsy: Implications for clinical trials.

Journal of neural transmission (Vienna, Austria : 1996)

Pathomechanisms of neuropsychiatric disturbances in atypical parkinsonian disorders: a current view.

AJNR. American journal of neuroradiology

The Value of Quantitative Susceptibility Mapping and Morphometry in the Differential Diagnosis of Parkinsonism.

An audit on the assessment and management of osteoporosis in a Parkinson's and related diseases clinic in Australia.

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

[Chronic epidural spinal cord stimulation for gait impairments in Parkinson's disease and atypical parkinsonism].

Possible Impact of Peripheral Inflammatory Factors and Interleukin-1β (IL-1β) on Cognitive Functioning in Progressive Supranuclear Palsy-Richardson Syndrome (PSP-RS) and Progressive Supranuclear Palsy-Predominant Parkinsonism (PSP-P).

Dysphagia in progressive supranuclear palsy: A scoping review.

Quality of life in patients with progressive supranuclear palsy: a review of literature and implications for practice.

Journal of neural transmission (Vienna, Austria : 1996)

Cognitive impairment in Parkinson's disease and other parkinsonian syndromes.

Differentiating atypical parkinsonian syndromes with hyperbolic few-shot contrastive learning.

NeuroImage

Japanese longitudinal biomarker study in progressive supranuclear palsy and corticobasal degeneration: Clinical features of the first registered patients and short-term follow-up analysis.

Journal of the neurological sciences

The Gunslinger's sign in atypical parkinsonism.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

Speech profile in different clinical PSP phenotypes: an acoustic-perceptual study.

Autoimmune Encephalitis and Paraneoplastic Neurological Syndromes with Progressive Supranuclear Palsy-like Manifestations.

Acute Levodopa Challenge in Atypical Parkinsonism: Comprehensive Analysis of Individual Motor Responses.

The possible connection between neutrophil-to-high-density lipoprotein ratio and cerebral perfusion in clinically established corticobasal syndrome: a pilot study.

Asymmetry in Atypical Parkinsonian Syndromes-A Review.

Precision Imaging in Neurodegeneration: The Superiority of Diffusion Tensor Imaging Over Conventional MRI in Differentiating Parkinson's Disease From Atypical Parkinsonian Syndromes.

Cureus

Neuropsychiatric disease and treatment

SEND-PD in Parkinsonian Syndromes: Results of a Monocentric Cross-Sectional Study.

Clinica chimica acta; international journal of clinical chemistry

Diagnostic value of six plasma biomarkers in progressive supranuclear palsy, multiple system atrophy, and Parkinson's disease.

AJNR. American journal of neuroradiology

Atypical Parkinsonian Syndromes: Structural, Functional, and Molecular Imaging Features.

CSF α-Synuclein Seed Amplification Assay in Patients With Atypical Parkinsonian Disorders.

Neurology

Impact of the Anticholinergic Burden on Disease-Specific Symptoms in Parkinsonian Syndromes.

Clinical Practices and Opinions toward Gastrostomy Use in Patients with Atypical Parkinsonian Syndromes: A National Survey in the UK.

Neurology. Clinical practice

A General Neurologist's Practical Diagnostic Algorithm for Atypical Parkinsonian Disorders: A Consensus Statement.

The associations between common neuroimaging parameters of Progressive Supranuclear Palsy in magnetic resonance imaging and non-specific inflammatory factors - pilot study.

Frontiers in immunology

Therapeutic advances in neurological disorders

The association of vagal atrophy with parameters of autonomic function in multiple system atrophy and progressive supranuclear palsy.

Structural parameters are superior to eigenvector centrality in detecting progressive supranuclear palsy with machine learning & multimodal MRI.

Heliyon

Determinants of care partner burden in atypical Parkinsonian syndromes: A retrospective, multi-center analysis.

Radiomics-Guided Deep Learning Networks Classify Differential Diagnosis of Parkinsonism.

Brain pathology (Zurich, Switzerland)

Upper motor neuron-predominant motor neuron disease presenting as atypical parkinsonism: A clinicopathological study.

The potential significance of hepcidin evaluation in progressive supranuclear palsy.

Brain and behavior

AJNR. American journal of neuroradiology

Usefulness of Olfactory Bulb Measurement in 3D-FIESTA in Differentiating Parkinson Disease from Atypical Parkinsonism.

Iron deposition in subcortical nuclei of Parkinson's disease: A meta-analysis of quantitative iron-sensitive magnetic resonance imaging studies.

Chinese medical journal

Anti-IgLON5 disease as a differential diagnosis of multiple system atrophy.

Effects of physiotherapy and home-based training in parkinsonian syndromes: protocol for a randomised controlled trial (MobilityAPP).

BMJ open

Parkinson's disease and Parkinsonism syndromes: Evaluating iron deposition in the putamen using magnetic susceptibility MRI techniques - A systematic review and literature analysis.

Heliyon

Histologic tau lesions and magnetic resonance imaging biomarkers differ across two progressive supranuclear palsy variants.

Brain communications

Expert opinion on pharmacotherapy

How can we manage progressive supranuclear palsy syndrome with pharmacotherapy?

Detecting Abnormal Eye Movements in Patients with Neurodegenerative Diseases - Current Insights.

Eye and brain

Clinical and Pathological Features of FTDP-17 with MAPT p.K298_H299insQ Mutation.

Current opinion in neurology

New knowledge on anti-IgLON5 disease.

European journal of neurology

Frequency and outcomes of gastrostomy insertion in a longitudinal cohort study of atypical parkinsonism.

Impulse Control Disorders in Parkinson's Disease and Atypical Parkinsonian Syndromes-Is There a Difference?

The significance of glial cell line-derived neurotrophic factor analysis in Progressive Supranuclear Palsy.

Scientific reports

Frontiers in bioscience (Landmark edition)

Dissecting the Clinical Heterogeneity and Genotype-Phenotype Correlations of MAPT Mutations: A Systematic Review.

Monash-Alfred protocol for assessment of atypical parkinsonian syndromes (MAP-APS).

BMJ neurology open

Glucose Metabolism and Cognitive Decline in Progressive Supranuclear Palsy and Corticobasal Syndrome: A Preliminary Study.

Neurologia i neurochirurgia polska

Comparison of autonomic dysfunction in patients with Parkinson's Disease, progressive supranuclear palsy, and multiple system atrophy.

Antioxidants (Basel, Switzerland)

Coenzyme Q10: A Biomarker in the Differential Diagnosis of Parkinsonian Syndromes.

The MAPT p.E342K and p.R406W mutations are associated with progressive supranuclear palsy with atypical features.

Progressive supranuclear palsy: A case report and brief review of the literature.

Radiology case reports

Clinical Phenotypes of Progressive Supranuclear Palsy-The Differences in Interleukin Patterns.

Serum GDF-15 Levels in Patients with Parkinson's Disease, Progressive Supranuclear Palsy, and Multiple System Atrophy.

Neurology international

Clinical neurology and neurosurgery

Atypical findings: Atypical parkinsonian syndromes or Atypical parkinsonian syndromes look-alikes.

Frontiers in aging neuroscience

Clinical features of progressive supranuclear palsy.

Advances in clinical chemistry

microRNA and circRNA in Parkinson's Disease and atypical parkinsonian syndromes.

Translational neurodegeneration

Large-scale proximity extension assay reveals CSF midkine and DOPA decarboxylase as supportive diagnostic biomarkers for Parkinson's disease.

Journal of cachexia, sarcopenia and muscle

Impaired skeletal muscle health in Parkinsonian syndromes: clinical implications, mechanisms and potential treatments.

PSP-Richardson syndrome mimics: An overview and pragmatic approach.

Revue neurologique

Rinsho shinkeigaku = Clinical neurology

[Autoimmune encephalitis and paraneoplastic neurological syndromes presenting atypical parkinsonism: a scoping review].

Brain imaging and behavior

[18F]-FDopa positron emission tomography imaging in corticobasal syndrome.

Large-scale activation likelihood estimation meta-analysis of parkinsonian disorders.

Brain communications

Neurological update: non-motor symptoms in atypical parkinsonian syndromes.

Movement disorders : official journal of the Movement Disorder Society

Whole-Brain Magnetic Resonance Spectroscopy Reveals Distinct Alterations in Neurometabolic Profile in Progressive Supranuclear Palsy.

Acta neuropathologica communications

Case report of a patient with unclassified tauopathy with molecular and neuropathological features of both progressive supranuclear palsy and corticobasal degeneration.

Movement disorders : official journal of the Movement Disorder Society

Slowing of Frontal β Oscillations in Atypical Parkinsonism.

Nuclear medicine and molecular imaging

Optimal Protocol and Clinical Usefulness of 123I-MIBG Cardiac Scintigraphy for Differentiation of Parkinson's Disease and Dementia with Lewy Body from Non-Parkinson's Diseases.

Diagnosis across a cohort of "atypical" atypical and complex parkinsonism.

Journal of neural transmission (Vienna, Austria : 1996)

Significance of clinical symptoms and red flags in early differential diagnosis of Parkinson's disease and atypical Parkinsonian syndromes.

Genetics of Multiple System Atrophy and Progressive Supranuclear Palsy: A Systemized Review of the Literature.

Brain : a journal of neurology

Progression of atypical parkinsonian syndromes: PROSPECT-M-UK study implications for clinical trials.

Neurologia i neurochirurgia polska

Sleep disturbances in progressive supranuclear palsy syndrome (PSPS) and corticobasal syndrome (CBS).

Journal of neural transmission (Vienna, Austria : 1996)

Comparative analysis of freezing of gait in distinct Parkinsonism types by diffusion tensor imaging method and cognitive profiles.

CSF Aβ42 and Aβ42/Aβ40 Ratio in Alzheimer's Disease and Frontotemporal Dementias.

Retinal Structure Abnormalities in Parkinson's Disease and Atypical Parkinsonism.

Biomolecules

Handbook of clinical neurology

The challenging quest of neuroimaging: From clinical to molecular-based subtyping of Parkinson disease and atypical parkinsonisms.

Complement system changes in blood in Parkinson's disease and progressive Supranuclear Palsy/Corticobasal Syndrome.

Comparison of mean diffusivity, R2* relaxation rate and morphometric biomarkers for the clinical differentiation of parkinsonism.

Higher prevalence of idiopathic normal pressure hydrocephalus-like MRI features in progressive supranuclear palsy: An imaging reminder of atypical parkinsonism.

Brain and behavior

Multiclass prediction of different dementia syndromes based on multi-centric volumetric MRI imaging.

NeuroImage. Clinical

Differences in Striatal Metabolism in [18F]FDG PET in Parkinson's Disease and Atypical Parkinsonism.

Movement disorders : official journal of the Movement Disorder Society

Neuromelanin-Sensitive Magnetic Resonance Imaging Changes in the Locus Coeruleus/Subcoeruleus Complex in Patients with Typical and Atypical Parkinsonism.

PDQ-8: A Simplified and Effective Tool Measuring Life Quality in Progressive Supranuclear Palsy.

The Use of Cerebellar Hypoperfusion Assessment in the Differential Diagnosis of Multiple System Atrophy with Parkinsonism and Progressive Supranuclear Palsy-Parkinsonism Predominant.

Oligomeric α-synuclein and tau aggregates in NDEVs differentiate Parkinson's disease from atypical parkinsonisms.

Neurobiology of disease

A meta-analysis of the diagnostic utility of biomarkers in cerebrospinal fluid in Parkinson's disease.

NPJ Parkinson's disease

Clinical outcomes and cognitive impairments between progressive supranuclear palsy and multiple system atrophy.

Brain and behavior

Rhythmic auditory cueing in atypical parkinsonism: A pilot study.

Speech acoustic indices for differential diagnosis between Parkinson's disease, multiple system atrophy and progressive supranuclear palsy.

NPJ Parkinson's disease

The Clinical neuropsychologist

Qualitative evaluation of the Rey-Osterrieth Complex Figure Test in patients with progressive supranuclear palsy.

Arquivos de neuro-psiquiatria

Progressive supranuclear palsy and corticobasal degeneration: novel clinical concepts and advances in biomarkers.

The Cognitive Profile of Atypical Parkinsonism: A Meta-Analysis.

Neuropsychology review

The Significance of Asymmetry in the Assessment of Brain Perfusion in Atypical Tauopathic Parkinsonian Syndromes.

Frontiers in aging neuroscience

Parkinsonian Syndromes in Motor Neuron Disease: A Clinical Study.

Characterization and diagnostic potential of R2* in early-stage progressive supranuclear palsy variants.

Experimental and therapeutic medicine

Probable progressive supranuclear palsy in a patient with chronic schizophrenia: A case report.

Zeitschrift fur Gerontologie und Geriatrie

[Atypical Parkinson's syndrome in old age].

Case Report: Presence of Anti-MAG in the CSF Can Be Associated With a Neurodegenerative Process With Frontal Involvement.

Is MRPI 2.0 More Useful than MRPI and M/P Ratio in Differential Diagnosis of PSP-P with Other Atypical Parkinsonisms?

The promise of amplification assays for accurate early detection of α-synucleinopathies: A review.

Experimental gerontology

European journal of nuclear medicine and molecular imaging

Decoding the dopamine transporter imaging for the differential diagnosis of parkinsonism using deep learning.

Advanced diffusion imaging to track progression in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy.

NeuroImage. Clinical

Medicina (Kaunas, Lithuania)

MicroRNA as Candidate Biomarkers in Atypical Parkinsonian Syndromes: Systematic Literature Review.

Differential diagnosis between Parkinson's disease and atypical parkinsonism based on gait and postural instability: Artificial intelligence using an enhanced weight voting ensemble model.

Utility of 18F FDG-PET in Parkinsonism in an African population.

eNeurologicalSci

Movement disorders : official journal of the Movement Disorder Society

Regional Selectivity of Neuromelanin Changes in the Substantia Nigra in Atypical Parkinsonism.

Automated Differentiation of Atypical Parkinsonian Syndromes Using Brain Iron Patterns in Susceptibility Weighted Imaging.

Journal of Alzheimer's disease : JAD

Patterns of Mixed Pathologies in Down Syndrome.

Movement disorders : official journal of the Movement Disorder Society

Dopaminergic Correlates of Regional Cerebral Blood Flow in Parkinsonian Disorders.

Brain and nerve = Shinkei kenkyu no shinpo

[Autonomic Dysfunction in Tauopathies].

Frontiers in neuroscience

A Panel of Plasma Biomarkers for Differential Diagnosis of Parkinsonian Syndromes.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Differential Diagnosis of Parkinsonism Based on Deep Metabolic Imaging Indices.

Frontiers in aging neuroscience

Differential Diagnosis of Rare Subtypes of Progressive Supranuclear Palsy and PSP-Like Syndromes-Infrequent Manifestations of the Most Common Form of Atypical Parkinsonism.

The Strengths and Obstacles in the Differential Diagnosis of Progressive Supranuclear Palsy-Parkinsonism Predominant (PSP-P) and Multiple System Atrophy (MSA) Using Magnetic Resonance Imaging (MRI) and Perfusion Single Photon Emission Computed Tomography (SPECT).

Is the Phenotype Designation by PSP-MDS Criteria Stable Throughout the Disease Course and Consistent With Tau Distribution?

Cerebral cortex (New York, N.Y. : 1991)

Diffusion microstructure imaging in progressive supranuclear palsy: reduced axonal volumes in the superior cerebellar peduncles, dentato-rubro-thalamic tracts, ventromedial thalami, and frontomesial white matter.

Clinical nuclear medicine

Complementary Utility of Dopamine Transporter and Tau PET Imaging in the Diagnosis of Progressive Supranuclear Palsy: A Case Report.

Eye-of-the-Tiger Sign with an Unexpected Pathological Diagnosis.

Alzheimer disease and associated disorders

Role of Apolipoprotein E in the Clinical Profile of Atypical Parkinsonian Syndromes.

Journal of integrative neuroscience

Pain in neurodegenerative diseases with atypical parkinsonism: a systematic review on prevalence, clinical presentation, and findings from experimental studies.

Therapeutic Application of rTMS in Atypical Parkinsonian Disorders.

Behavioural neurology

Presence of Skin α-Synuclein Deposits Discriminates Parkinson's Disease from Progressive Supranuclear Palsy and Corticobasal Syndrome.

Neuro-degenerative diseases

Cerebrospinal Fluid Levels of 5-Hydroxyindoleacetic Acid in Parkinson's Disease and Atypical Parkinsonian Syndromes.

Neurologia i neurochirurgia polska

Neuroimaging in Parkinson's Disease: necessity or exaggeration?

Neurofilament light chain and α-synuclein RT-QuIC as differential diagnostic biomarkers in parkinsonisms and related syndromes.

NPJ Parkinson's disease

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

"Parkinson's disease" on the way to progressive supranuclear palsy: a review on PSP-parkinsonism.

Frontiers in molecular neuroscience

Novel Therapies for Parkinsonian Syndromes-Recent Progress and Future Perspectives.

European journal of neurology

Corpus callosum hypersignals and focal atrophy: Neuroimaging findings in globular glial tauopathy type I.

The Genetic Landscape of Parkinsonism-Related Dystonias and Atypical Parkinsonism-Related Syndromes.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

Lower urinary tract dysfunction in Parkinsonian syndromes.

123I-Metaiodobenzylguanidine Myocardial Scintigraphy in Discriminating Degenerative Parkinsonisms.

Prevalence and Characteristics of Polyneuropathy in Atypical Parkinsonian Syndromes: An Explorative Study.