Tifoide

CVD 38000: Study of Responses to Vaccination With Typhoid and/or Cholera

NCT03705585

RECRUTANDO

Transcriptomic Responses for the Identification of Pathogens

NCT04878549

RECRUTANDO

CVD 37000: Immunity and Microbiome Studies at Intestinal and Systemic Sites in Ty21a Vaccinated Adults

NCT03970304

EM ANDAMENTO

Induction of Gut Permeability by an Oral Vaccine

NCT04083950

EM ANDAMENTO

Clinical Efficacy of Typhoid Conjugate Vaccine (Vi-TCV) Among Children Age 9 Months Through 12 Years in Blantyre, Malawi

NCT03299426

EM ANDAMENTO

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Outros ensaios clínicos

88 ensaios clínicos encontrados, 8 ativos.

Distribuição por fase

NCT03970304 · CVD 37000: Immunity and Microbiome Studies at Intestinal and…Ativo

NCT04083950 · Induction of Gut Permeability by an Oral VaccineAtivo

EARLY_PHASE1

NCT03299426 · Clinical Efficacy of Typhoid Conjugate Vaccine (Vi-TCV) Amon…Ativo

PHASE3

NCT05870150 · Challenge Non-Typhoidal Salmonella (CHANTS) StudyAtivo

NA

NCT06921460 · Long-Term Protection of Vi Antibodies Induced by Bio TCV in …Em breve

NCT06757283 · ZyVac-TCV Bangladesh StudyEm breve

PHASE3

NCT05500482 · Vellore Typhoid Vaccine Impact TrialConcluído

NCT07445282 · This Randomized Controlled Trial Evaluates the Comparative E…Concluído

NCT04349826 · The Azithromycin and Cefixime Treatment of Typhoid in South …Concluído

NCT04543877 · WHNRC (Western Human Nutrition Research Center) Fiber Interv…Concluído

EARLY_PHASE1

NCT07150065 · Efficacy of Levofloxacin Versus Ciprofloxacin in the Treatme…Concluído

PHASE2

NCT03614533 · Typhoid Conjugate Vaccine Trial Among Children Younger Than …Concluído

PHASE2

NCT06546982 · Diagnosis and Staging of Typhoid Fever Using Surface-enhance…Concluído

NA

NCT05613205 · Safety and Immunogenicity of a Novel Conjugate Vaccine Again…Concluído

PHASE1

NCT05475379 · Non-inferiority Trial of Locally Manufactured Typhoid Conjug…Concluído

PHASE1, PHASE2

NCT03312699 · Effects of Aging on Primary and Secondary Vaccine ResponsesConcluído

PHASE1

NCT06104345 · Immune Response Elicited by Concomitant Administration of Or…Concluído

NCT00679172 · Immunogenicity, Safety and Tolerability of the Typhoid Fever…Concluído

PHASE2

Ver todos no ClinicalTrials.gov

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Publicações mais relevantes

Timeline de publicações

3.046 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 3.046

#1

Optimising DTwP-containing vaccine infant immunisation schedules in Uganda and Nepal (OptImms): two open-label, non-inferiority, randomised controlled trials.

The Lancet. Infectious diseases2026 Mar 19

Few data are available comparing the WHO diphtheria-tetanus-pertussis (DTP)-containing vaccine schedule with reduced-dose or delayed three-dose schedules in infants. We aimed to identify an alternative schedule that is non-inferior or superior to the WHO schedule in maintaining early pertussis antibody levels before booster, while creating space for integration of new vaccines. In two parallel, open-label, randomised, non-inferiority trials in Uganda and Nepal, healthy infants aged 42-50 days were randomised in a 4:4:4:3:3 ratio via an online system to five diphtheria-tetanus-whole-cell pertussis-Haemophilus influenzae type b-hepatitis B (DTwP-Hib-HepB) vaccination schedules (WHO schedule [ages 6, 10, and 14 weeks]; reduced two-dose schedules at ages 6 and 14 weeks or ages 2 and 4 months; or delayed three-dose schedules at ages 2, 3, and 4 months or ages 2, 4, and 6 months), using site-stratified block randomisation with a block size of 18. The primary outcome was the pre-booster IgG antibody response against pertussis antigens (pertussis toxin; filamentous haemagglutinin [FHA]; pertactin; fimbriae 2 and 3 [Fim 2 and 3]). Antibody responses during and 1 month after the primary series were assessed as secondary endpoints. The two-dose schedules were compared with the WHO schedule as primary analyses, and the exploratory analyses were to compare delayed three-dose schedules with the WHO schedule. All these analyses were conducted in the per-protocol population. For the primary endpoint, non-inferiority margins for geometric mean ratios (GMRs) between two-dose and WHO schedules were calculated for each pertussis antigen separately as 35% of the standard deviation of the geometric mean concentrations of the WHO group, and non-inferiority was concluded if the lower bound of the 95% CI of the GMR exceeded the non-inferiority margin. A non-inferiority margin of 0·67 was used for all other non-inferiority comparisons. The trials were registered with ISRCTN (Uganda [ISRCTN60356654] and Nepal [ISRCTN12240140]) and are complete. Between Oct 1, 2021, and July 12, 2022 (Uganda) and Dec 5, 2021, and Feb 26, 2023 (Nepal), 956 infants were recruited per country and randomly allocated across the five study groups; pre-booster analyses were conducted in 876 participants in Uganda and 851 participants in Nepal. Two-dose schedules at ages 6 and 14 weeks and ages 2 and 4 months did not meet non-inferiority criteria for pertussis antibodies pre-booster, except FHA (non-inferiority margin 0·59) in Nepal (6 and 14 weeks GMR 0·83 [95% CI 0·61-1·13]; 2 and 4 months 1·20 [0·88-1·64]). Delayed three-dose schedules at ages 2, 3, and 4 months and ages 2, 4, and 6 months produced similar or higher post-primary series and pre-booster responses compared with the WHO schedule, but the WHO schedule achieved higher antibody responses against all pertussis antigens, except FHA in Nepal, at age 3 months. The WHO DTP schedule is the preferred schedule in high-pertussis-burden settings, as it elicits the greatest antibody responses in the first 3 months of life when infants are particularly vulnerable. Although delayed three-dose schedules may be considered in low-risk contexts and in settings with maternal immunisation programmes, early infant protection should guide policy decisions. Gates Foundation.

#2

The diagnostic void: how typhoid-by-default drives antimicrobial resistance in Ethiopia.

The Lancet. Microbe2026 Mar 16

The empirical diagnosis of typhoid-by-default represents a severe failure in Ethiopia's management of febrile illnesses. This practice of diagnosing undifferentiated fever as typhoid without confirmation drives antimicrobial resistance (AMR) through a unique diagnostic ecosystem shaped by historical precedent, systemic constraints, community demand, and reliance on the outdated Widal test. This diagnostic void promotes empirical use of broad-spectrum antibiotics, selecting for resistant Salmonella enterica serotype Typhi, while contributing to the spread of AMR in commensal organisms and other pathogens. This practice contributes to a broader AMR crisis that extends beyond enteric fever, compromising the treatment of urinary, respiratory, and other common infections. The result is a self-perpetuating cycle of multisystem treatment failures, excess mortality, and economic loss. In this Personal View, we discuss the steps required to break this cycle: eliminating the Widal test, implementing validated diagnostic algorithms for febrile presentation, expanding diagnostic access, introducing typhoid vaccines, and establishing antimicrobial stewardship programmes. Addressing this issue is an urgent public health priority for both national and global AMR containment.

#3

Ceftriaxone-resistant multidrug-resistant Salmonella Typhi sepsis in pregnancy.

BMJ case reports2026 Mar 09

A primigravida at 26 weeks' gestation visiting from Pakistan presented with fever, abdominal pain and hypotension suggestive of sepsis and required admission to the intensive care unit. Blood culture grew a multidrug-resistant (MDR) Salmonella enterica serovar Typhi isolate that was resistant to cephalosporins but susceptible to carbapenems. Intravenous meropenem was commenced, resulting in a rapid clinical improvement within 48 hours. She completed a 14-day course of meropenem without maternal or fetal adverse effects, and repeat blood cultures were sterile. The remainder of her pregnancy was uncomplicated, and she delivered a healthy term infant. This case highlights the diagnostic and therapeutic challenges of MDR, cephalosporin-resistant Salmonella Typhi infection during pregnancy and supports meropenem as an effective and potentially life-saving treatment associated with favourable maternal and fetal outcomes.

#4

Long-term mortality and cause of death in people with tuberculosis compared with matched controls with influenza or non-typhoid salmonellosis in Australia: a retrospective cohort study.

BMJ public health2026

Tuberculosis (TB) patients are thought to experience excess long-term morbidity and mortality. However, the long-term mortality of people with TB has not been compared with other common infections to assess their overall and disease-specific causes of death. All people diagnosed with TB between 2000 and 2015 in New South Wales, Australia, were matched by age, sex and year of infection to notified cases of influenza or non-typhoid salmonellosis. Patients were linked to the Australian mortality register to assess date and cause of death, up until the end of 2022. The comparative mortality ratio (CMR) for each cohort was calculated and Kaplan-Meier survival curves constructed. The standardised mortality rate (SMR) was estimated using national mortality data. The CMR of 7386 people with past TB was marginally increased (1.16 with 95% CI 1.10 to 1.22) compared with non-typhoid salmonellosis but reduced compared with influenza (0.88 with 95% CI 0.84 to 0.93). Most deaths occurred within 10 years of the notified infection. For TB patients, 1162 of 1331 people (87.3%) died in the 10 years after TB diagnosis. Risk factors for long-term mortality among TB patients included age over 40 years, male sex, sputum smear-positive and intracranial disease. Respiratory causes of death, including chronic obstructive pulmonary disease, lung cancer and pneumonia, were increased for TB patients, while influenza patients suffered more cardiovascular deaths. The SMR for TB patients (compared with the Australian general population) was increased by 18.7 times for infectious causes of death, 2.8 times for respiratory causes and 1.4 times for cancer-related mortality. Despite successful treatment, people with TB often experience post-TB sequelae and increased long-term mortality, with increased risk of respiratory causes of death. This highlights the need for appropriate post-TB respiratory follow-up, particularly in the first 10 years after TB diagnosis.

#5

Country-level perspectives and priorities to guide the development of Invasive non-Typhoidal Salmonella (iNTS) vaccines: Insights from seven countries.

PLoS neglected tropical diseases2026 Feb

Invasive non-typhoidal Salmonella (iNTS) disease typically presents as a non-specific febrile illness that can progress to bloodstream infections and carries a high case fatality rate. Early detection improves patient outcomes, however, in resource-constrained settings, limited diagnostic capacity leads to underdiagnosis, insufficient incidence data, and incomplete epidemiological and socio-economic research on iNTS. Although no licensed vaccines currently exist, several candidates are in pre-clinical and clinical development. In the early stages of vaccine development, it is essential to consider country-level perspectives and priorities to guide the development of novel vaccines. To support this, the World Health Organization's Vaccine Innovation Framework was applied to conduct a consultation with 40 stakeholders representing the national immunization programmes in Burkina Faso, Ghana the Gambia, the Democratic Republic of the Congo (DRC), Kenya, Malawi and Mozambique. The consultation aimed to assess the stakeholder perceptions on the need for an iNTS vaccine and to evaluate its desirability, suitability, and evidence requirements from a low- and middle-income country (LMIC) perspective. Stakeholders argued that although an iNTS vaccines is desirable, the lack of nationally available epidemiological data is a barrier to accurately understanding the disease burden. A novel vaccine would be more desirable if it aligns with the preferred product characteristics specified, and helps mitigate, rather than exacerbate, current immunization programme challenges. They also expressed a preference for combination vaccines that align programmatically, including formulations combining iNTS with typhoid conjugate vaccine (TCV), to reduce the number of injections and simplify delivery logistics. To make evidence-based decisions on potential introduction, stakeholders emphasized the need for robust data on the value and impact of iNTS vaccines.

Publicações recentes

Comprehensive Phytochemical Profiling and Chemotypic Variation Study of Three Medicinally Important Oncosiphon Species Indigenous to South Africa.

Plants (Basel)2026 Mar 28

Typhoid Toxin of Salmonella enterica Induces ISG15 Responses Mediating Host Cell Survival and Counteracting Intracellular Infection.

Mol Microbiol2026 Apr 13

Evaluation of the Efficacy of Different Vaccination Programs Using Two Live Salmonella Vaccines Against Salmonella Enteritidis, Salmonella Typhimurium, and Salmonella Gallinarum in Brown Layer Hens.

Avian Dis2026 Apr

Case Report: Acute acalculous cholecystitis due to Salmonella Typhi: a case of conservative treatment failure and review of the literature.

Front Surg2026

Ver todas no PubMed

📚 EuropePMC10.387 artigos no totalmostrando 200

Open forum infectious diseases

From Crisis to Control: A Study of Typhoid Conjugate Vaccine Efficacy in Harare, Zimbabwe (2017-2024).

The Lancet. Infectious diseases

Optimising DTwP-containing vaccine infant immunisation schedules in Uganda and Nepal (OptImms): two open-label, non-inferiority, randomised controlled trials.

Emerging infectious diseases

Seroincidence Rate of Typhoidal Salmonella in Children, Kenya, 2017-2018.

The diagnostic void: how typhoid-by-default drives antimicrobial resistance in Ethiopia.

The Lancet. Microbe

Critical reviews in microbiology

Friends and foes: impact of bacteria on genome stability.

Human vaccines & immunotherapeutics

Development and validation of immunological assays for preclinical evaluation of a novel bivalent typhoid conjugate vaccine.

Genomic and phenotypic characterization of plasmid-mediated extensively drug-resistant Salmonella Typhi from Lahore Pakistan carrying IncY IncQ1 and IncC replicons.

International journal of surgery case reports

Atypical typhoid fever with pancytopenia, electrolyte imbalance, cholestatic hepatitis, and pleural effusion in an adolescent: a case report.

A case of laboratory-acquired Salmonella Typhi infection due to phage typing in Japan: whole-genome sequencing confirms the source of infection.

Access microbiology

Current pharmaceutical design

Molecular Insights into the MdtABC Efflux Pump Genes in Clinical Salmonella typhi Isolates from Typhoid Patients.

The Journal of the Association of Physicians of India

Alterations in Serum Electrolytes among Adults with Enteric Fever: A Retrospective Observational Study from a Tertiary Center in New Delhi.

Enhanced Salmonella mortality in naturally resistant, immunocompetent male mice is associated with an altered systemic immune response.

Infection and immunity

Effectiveness of the TYPHIBEV® (Vi-CRM197 conjugate) vaccine introduction in Nepal: A test-negative, case-control study.

The Journal of infection

Examining the effects of climate and environmental hazards on vector and water-borne diseases in Eastern Uganda.

Discover Environment

Ceftriaxone-resistant multidrug-resistant Salmonella Typhi sepsis in pregnancy.

BMJ case reports

Long-term mortality and cause of death in people with tuberculosis compared with matched controls with influenza or non-typhoid salmonellosis in Australia: a retrospective cohort study.

BMJ public health

Transactions of the Royal Society of Tropical Medicine and Hygiene

Typhoid knowledge, prevention practices, and vaccine awareness in high-risk communities of Lilongwe, Malawi.

JNMA; journal of the Nepal Medical Association

Shifting Enteric Fever Epidemiology in Children in Nepal: Is the Burden of Salmonella Paratyphi on the Rise?

Evaluation of mdh, dld, tcfA, and folE gene markers for detection of enteric fever using real-time PCR.

Molecular epidemiological and genetic variability of Salmonella isolates from the tropical mountainous region of southern China (2017-2024).

Microbiology spectrum

Bactericidal, Bacteriostatic, and Fungicidal Activities of Clausena anisata Fruit and Its Compounds, Stigmasteryl 3-Palmitate (a Phytosterol Ester) and Phellopterin (a Furanocoumarin), Against Some Clinical Pathogens.

MicrobiologyOpen

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi

[Epidemiological characteristics of typhoid fever and paratyphoid fever outbreaks in China from 2008 to 2024].

Clinical Audit of Enteric Fever Diagnostic Practices at Kosti Teaching Hospital: A Retrospective Evaluation.

A Novel Loop-Mediated Isothermal Amplification (LAMP) Primer Set for Detecting the STY2879 Gene of Salmonella enterica Serovar Typhi in Raw Milk.

Microorganisms

Country-level perspectives and priorities to guide the development of Invasive non-Typhoidal Salmonella (iNTS) vaccines: Insights from seven countries.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences

Role of pneumococcal and typhoid conjugate vaccines in mitigating antimicrobial resistance: report of conference proceeding.

Successful Surgical Treatment in Empyema Caused by an Atypical Pathogen: Non-typhoid Salmonella.

Inflammatory models of depression in rodents and humans.

Frontiers in psychiatry

International journal of biological macromolecules

Design and structural characterization of a chimeric protein displayed on virus-like particles for targeted immune activation against Salmonella Typhi.

Statistical methods for predicting the presence of Salmonella Typhi in wastewater samples at Asante Akyem Agogo, Ghana.

UHPLC-QTOF-ESI-/MS characterised methanolic leaves extract of Momordica foetida Schumach. (Cucurbitaceae: Cucurbitales) possesses anti-Salmonella properties: In vitro, in vivo, molecular docking and molecular dynamics simulations approach.

Fitoterapia

Journal of infection and public health

Target product profile to guide development of next generation diagnostic test for Salmonella enterica: Responding to the crisis of drug resistant typhoid.

The gut microbiota in Salmonella Typhi infection and translocation: Mechanisms of colonization resistance, pathogen subversion, and prospects for microecological intervention.

Microbial pathogenesis

Italian journal of food safety

Non-typhoidal Salmonella prevalence and risk factors among outpatients at public health facilities in Gondar City, northwest Ethiopia.

A wide proteome analysis to engineer an efficient epitope based vaccine against Salmonella typhi: An immunoinformatic study.

Human immunology

Annals of medicine and surgery (2012)

Prolonged transaminitis in typhoid hepatitis: a rare case report with a diagnostic dilemma from Nepal.

medRxiv : the preprint server for health sciences

Estimating enteric fever seroincidence in rural western Cambodia: findings from a population-based cross-sectional serosurvey.

Journal of infection in developing countries

Analysis of chromosomal genes and proteins of gyrA and gyrB from Indonesian Local-Strain Salmonella enterica serovar Typhi.

Assessment of Knowledge and Attitudes Related to Food Hygiene Among Food Business Operators in Attica, Greece.

Identification of antimicrobial compounds in Dipsacus inermis via phytochemical profiling, in vitro assessment, and advanced computational techniques.

PloS one

Southern African journal of infectious diseases

Acute G6PD deficiency haemolytic crises with associated methaemoglobinaemia in a patient with typhoid.

medRxiv : the preprint server for health sciences

Estimating enteric fever seroincidence in Bangladesh using rapid serosurveys.

Indian journal of medical microbiology

Tracking antimicrobial resistance in typhoidal Salmonella, 2020-2024: Output from an antimicrobial resistance surveillance network in New Delhi, India.

Musculoskeletal infections caused by Salmonella Typhi: A series of two case reports in immunocompetent adults.

Tropical doctor

Journal of travel medicine

Co-administration of oral killed whole-cell recombinant cholera toxin B-subunit vaccine (WC-rCTB) and live Salmonella Typhi Ty21a vaccine: a prospective randomized open-label trial.

An Unusual Presentation of Secondary Hemophagocytic Lymphohistiocytosis With Melena: A Case Report.

Specific detection of Salmonella Typhi by probe-free quantitative polymerase chain reaction.

Archives of microbiology

Typhoid Fever goes rogue: A rare & unusual case of concurrent typhoid hepatitis and splenic abscess in an immunocompetent adult.

IDCases

Exploring barriers to and motivations for vaccine uptake in a typhoid vaccine trial in Vellore, South India: a qualitative study.

BMC public health

Phase II multicentre double-blind randomised controlled trial of a Bivalent VaccInation against Salmonella Typhi and Paratyphi A (BiVISTA) using a controlled human infection model of paratyphoid A infection: study protocol.

BMJ open

Current health sciences journal

Autopsy Analysis of Sudden Deaths in Adults: Causes and Demographics from a One-Year Prospective Study.

Incidence and healthcare costs of symptomatic dengue in an urban, city-wide cohort in South India.

Western Pacific surveillance and response journal : WPSAR

Investigation of an outbreak of typhoid fever in a rural district of East Malaysia, 2019.

Infectious diseases of poverty

Evaluating the diagnostic accuracy of clinical judgement and rapid tests for leptospirosis in the Philippines: implications for public health management.

Impact of the COVID-19 pandemic and typhoid conjugate vaccine introduction on typhoid fever in Nepal.

Deutsches Arzteblatt international

Infections After International Travel: Relevant Diagnoses in Children and Adolescents.

Veterinary research communications

Evaluation of immunogenicity and protective efficacy of Salmonella Gallinarum knockout purB mutant strain in chicken.

The Journal of antimicrobial chemotherapy

Rapid molecular diagnostics for detection of extensively drug-resistant Salmonella Typhi.

The Lancet regional health. Southeast Asia

Burden of typhoid fever and antimicrobial resistance in India (2023): a modelling study.

Clinical Characteristics and Resistance Patterns of Extensively Drug-Resistant Salmonella Typhi in the Pediatric Population of Pakistan: A Prospective Study.

Sage open pediatrics

A new mouse model of typhoid fever using Salmonella enterica serovar Paratyphi C as a surrogate pathogen.

mBio

Water environment research : a research publication of the Water Environment Federation

Waterborne Diseases in Algeria (2000-2023): Spatiotemporal Trends Analysis and Public Health Determinants.

Biomedical chromatography : BMC

Study on the Effect and Mechanism of Lomatogonium rotatum (L.) Fries ex Nym Extract on NAFLD Through Metabolomics.

Folia histochemica et cytobiologica

A recombinase polymerase amplification-coupled Cas12a for detection of Salmonella Typhi - a preliminary report.

Journal of surgical case reports

Spontaneous colonic perforation in a pediatric patient with acute febrile illness: a case report.

Healthcare (Basel, Switzerland)

Geographic and Behavioral Determinants of Typhoid and Antimicrobial Resistance in Children Across Urban, Rural, and Nomadic Populations of Punjab, Pakistan.

Typhoid Fever in Indonesia: Pitfalls in the Diagnosis of Typhoid Fever.

Acta medica Indonesiana

Gut microbiota dysbiosis and predicted metabolic functional shifts associated with fowl typhoid in layer hens.

Poultry science

Emerging infectious diseases

Carbapenem-Resistant Salmonella Typhi Infection in Traveler Returning to Germany from India, 2024.

Bioresources and bioprocessing

Application of image analysis combined with regression models to estimate the reduction of Escherichia coli and Salmonella spp. on vegetable surfaces after washing.

World journal of gastroenterology

Decoding Alexander the Great's gastrointestinal cause of death using artificial wisdom: An artificial intelligence-human inquiry into a medical mystery.

Epidemiological characteristics and spatial clustering analysis of typhoid and paratyphoid fevers in China, 2014-2022.

[History of typhoid vaccination].

La Revue du praticien

International journal of molecular sciences

A Dual-Gene Colorimetric LAMP Assay for Genus-Level Detection of Salmonella and Specific Identification of the Non-Motile Serovar S. Gallinarum Gallinarum.

Typhoidal tularemia with pancytopenia and pericarditis in a georgian adolescent.

IDCases

Efficacy, immunogenicity, and safety of typhoid conjugate vaccines in children and adolescents: a systematic review and meta-analysis.

Infection

Pakistan journal of medical sciences

Frequency of typhoid-related intestinal perforation with atypical clinical presentation at Tertiary Care Hospital in Pakistan.

European journal of medicinal chemistry

Overcoming multidrug- and extensively drug-resistant Salmonella Typhi with natural product-metal synergy: Evidence of DNA polymerase inhibition and cell membrane disruption.

Case reports in infectious diseases

Profound Sensorineural Hearing Loss Following Typhoid Fever in a Young Adult Female: A Rare Complication.

Transboundary and emerging diseases

Animal Disease Burden in Nigeria, 2006-2023.

Safety, immunogenicity and preliminary protective efficacy of a bivalent bacterial ghost vaccine against typhoidal Salmonella in rabbits: a pilot study.

JPMA. The Journal of the Pakistan Medical Association

Enteric susceptibility profile: Finding hope amidst despair.

Frontiers in microbiology

Phage therapy for intestinal infections: efficacy, challenges, and future directions in translational research.

Frontiers in microbiology

Emergence of carbapenem-resistant Salmonella Typhi harboring bla NDM-5 in India: genomic evidence from a multicenter study.

Dengue virus infection amongst malaria and typhoid fever suspected acute febrile patients in the Niger river basin of Nigeria.

A mouse model for studying chronic Salmonella Typhi infection and anti-biofilm interventions.

mBio

Journal of tropical medicine

Spatial and Temporal Distribution of Febrile Illnesses in Uganda: Case Studies of Brucellosis, Malaria and Typhoid Fever (2016-2023).

Seroresponse to repeated infections with Salmonella enterica Typhi and Paratyphi A.

Epidemics

Inquiry : a journal of medical care organization, provision and financing

Exploring Water, Sanitation, and Hygiene Status and Health Outcomes in Zimbabwe: A Scoping Review of Literature.

Frontiers in microbiology

Whole genome sequencing as a reliable alternative for Salmonella serotyping: a comparative study with the gold-standard method.

Characterization of Ty21a immunostimulatory effects in the mouse bladder.

Frontiers in immunology

Prospective characterisation of drug-resistant bloodstream infections in Africa and Asia (ACORN2): a surveillance network assessment.

The Lancet. Microbe

High prevalence of multi-drug resistant H58 Salmonella Typhi and emerging fluoroquinolone resistance among febrile children in Nairobi County, Kenya.

In silico pathogenomics of draft metagenome-assembled genome of gut Enterobacter cloacae from a gastroenteritis patient exhibiting potential determinants of multi-drug resistance and virulence.

Antonie van Leeuwenhoek

BMJ open respiratory research

Adapting global guidelines to local contexts: optimising community-acquired pneumonia (CAP) specific prescribing in Pakistan to counter antimicrobial resistance.

Functional role of 18 LysR-Type transcriptional regulators of Salmonella enterica serovar Typhi.

PloS one

Chronic carriers and multidrug resistance in typhoid fever: pathogenesis, challenges, and integrated control strategies.

Infection

Association between climatic conditions and infectious diseases: implications for Central Ethiopia region.

Environmental health insights

The Influence of Socioeconomic Factors on Open Defecation and Fecal Oral diseases in Soin ward, Kericho County, Kenya.

Typhi Mykrobe: fast and accurate lineage identification and antimicrobial resistance genotyping directly from sequence reads for the typhoid fever agent Salmonella Typhi.

Genome medicine

Typhoid toxin of Salmonella Typhi elicits host antimicrobial response during acute typhoid fever.

EMBO molecular medicine

Detection of Acute Tropical Fever Pathogens via Multiplex Polymerase Chain Reaction: A Cross-Sectional Study to Guide Appropriate Antimicrobial Use in Communities.

Acute Acalculous Cholecystitis Complicating Typhoid Fever: A Case Report.

Journal of health, population, and nutrition

Towards good health and wellbeing: understanding health conditions and healthcare needs among informal caregivers of older adults in Ghana.

Journal of cardiothoracic surgery

Asymptomatic diaphragmatic hernia in an elderly patient: case report and review of conservative management.

Tropical medicine and infectious disease

Communicable Disease Surveillance in South Africa and LMICs: A Systematic Review of Systems, Challenges, and Integration with Environmental Health.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Climate variability and infectious disease burden in Coastal Sindh, Pakistan: A trend analysis (2019-2022).

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Parallel Genome-Wide CRISPR Screens Reveal SORL1 and ZFYVE19 as Sequential Host Determinants of Salmonella Infection.

Computational biology and chemistry

Modeling typhoid dynamics using recurrent neural networks with Bayesian regularization.

Journal of parasitology research

Malaria and Typhoid Fever Coinfection Among Febrile Patients Attending a Health Facility in Yaoundé, Cameroon: A Cross-Sectional Study.

Clinical Spectrum and Outcomes of Typhoid Fever: A Retrospective Study.

International journal of microbiology

Analysis of the Epidemiological Profile of Typhoid Fever in the State of Pará Between the Years 1999 and 2018.

The Lancet. Infectious diseases

Complications and mortality of typhoid fever: an updated global systematic review and meta-analysis.

The Lancet. Global health

Safety and non-inferiority of multidose and single-dose vial formulations of EuTCV Vi-CRM197 versus Typbar TCV in healthy participants in Kenya and Senegal: a multicentre, observer-blind, randomised, phase 3 study.

Travel medicine and infectious disease

Hemophagocytic lymphohistiocytosis secondary to typhoid fever: a diagnostic challenge.

National trends in burden of enteric infections in China: Shifts from 1990 to 2021.

Infectious medicine

Neonatal tropical infections: A case series and clinical insights.

Tropical doctor

Functional synergy of heteropentameric B subunits underlies virulence in a Salmonella A2B5 toxin.

PLoS pathogens

A contemporary genomic snapshot of Salmonella Paratyphi A in Pakistan.

Microbial genomics

Splenic Infarction: An Unusual Complication of Salmonella Infection.

Malaria and typhoidal co-infection among febrile patients: a health facility-based cross-sectional study in Northern Ghana.

Therapeutic advances in infectious disease

The impact of meteorological variables on Salmonella bacteraemia in Mysuru District, Karnataka State, India: a retrospective time-series analysis.

Prioritization of future new vaccines introduction: The experience of the Ethiopian National Immunization Technical Advisory Group.

Report from the World Health Organization's Immunization and Vaccines-related Implementation Research Advisory Committee (IVIR-AC) meeting, virtual gathering, 1-5 September 2025.

Avian pathology : journal of the W.V.P.A

Antibiotic resistance and first comprehensive genomic characteristics of Salmonella Gallinarum isolated from poultry in Morocco.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Regional burden of undifferentiated fever and leading infectious etiologies of acute febrile illness in low- and middle-income countries: a meta-analysis.

The New England journal of medicine

Safety, Efficacy, and Immunogenicity of a Salmonella Paratyphi A Vaccine.

Lacticaseibacillus rhamnosus D1 Fermented Milk Confers Protection Against Typhoid Fever Through Immunomodulation and Gut Microbiota Regulation in Mice.

Microorganisms

Pathogens (Basel, Switzerland)

Whole-Genome Sequencing Analysis of Drug-Resistant Salmonella Typhi in Children.

International journal of environmental research and public health

Microbial and Chemical Water Quality Assessments Across the Rural and Urban Areas of Nepal: A Scoping Review.

Waterborne Diseases in a Rural Community in Pakistan: Awareness, Impact, and Corrective Measures.

Preventive medicine reports

Diagnostic accuracy of three tests for Salmonella Typhi infection in adult patients presenting to health facilities in an informal urban settlement in Nairobi, Kenya.

Psoas abscess caused by non-typhoid Salmonella in a man with human immunodeficiency virus (HIV): A rare case report.

IDCases

International immunopharmacology

Compensatory role of endogenous sulfur dioxide in hydrogen sulfide deficiency-induced microglial inflammation.

Phytochemical Profiling, Bioactivity Evaluation and In Silico Insights Onto Goniothalamus simonsii Hook. f. Thoms.: An Endangered Medicinal Plant.

Chemistry & biodiversity

Computers in biology and medicine

A proteo-genomic comparative analysis reveals an exceptional secretory system type 4 as determinant of evolution resistance in extensively drug resistant H58 Salmonella typhi.

Real-world vaccine effectiveness of typhoid conjugate vaccine in children and adolescents: a systematic review and meta-analysis.

The Many Faces of Enteric Fever: A Case Report on Septic Shock With Tachyarrhythmias, Icterus With Isolated Thrombocytopenia, and Enterocolitis With Leukopenia.

Journal of infection and public health

Malaria epidemiology, clinical characteristics, and concurrent infections in Delhi, India: A hospital-based study.

HilE mediates motility thermoregulation in typhoidal Salmonella serovars at elevated physiological temperatures.

PLoS pathogens

Wei sheng yan jiu = Journal of hygiene research

[Preliminary quantitative risk assessment of non-typhoid Salmonella in raw chicken meat sold in Beijing in 2022].

Advancing typhoid conjugate vaccine implementation in Asia: Regional policy priorities.

Diagnostic microbiology and infectious disease

Malaria and salmonella typhi co- infection and antibiotic susceptibility in febrile patients at the Buea Regional Hospital.

2024

Considerations in planning a controlled human infection model in at-risk groups in sub-Saharan Africa: the case for pneumococcal challenge in people living with HIV in Malawi and a report of stakeholder consultation.

Wellcome open research

Reduction of Salmonella gallinarum in poultry with phage-based interventions.

The Lancet. Public health

The burden of bacterial antimicrobial resistance in the WHO Eastern Mediterranean Region 1990-2021: a cross-country systematic analysis with forecasts to 2050.

Un-Matched 1:1 Retrospective Case-Control Study of the Transmission of Typhoid Fever in Neno District, Malawi.

Public health challenges

Leveraging paired serology to estimate the incidence of typhoidal Salmonella infection in the STRATAA study.

PLOS global public health

Oxidative stress in malaria and typhoid fever: A scoping review of the pathogenic mechanisms and therapeutic implications.

A combination typhoid and non-typhoidal Salmonella polysaccharide conjugate vaccine in healthy adults: a randomized, placebo-controlled phase 1 trial.

Nature medicine

Nutritional status and bacteremia patterns in children with diarrheal diseases: A comparative analysis of bacteremia from Salmonella Typhi versus other pathogens.

PloS one

Effective strategies for typhoid conjugate vaccine delivery: Health and economic insights from the 2015 Kampala outbreak.

Surgical Complications of Typhoid Fever: First National Typhoid Conference in Niamey, Niger.

Gates open research

Gamma-irradiated Salmonella Gallinarum oral vaccine elicits robust cellular and humoral immune responses in a chicken model.

Diagnostic microbiology and infectious disease

Incidence and antimicrobial resistance profile of multi-drug resistant Salmonella typhi isolated from blood samples in Khyber Pakhtunkhwa, Pakistan.

Journal of ethnopharmacology

Bile-processed coptidis rhizoma water extract alleviates insulin resistance induced by glucosamine in HepG2 cells by activating the PI3K/AKT/FoxO1 signaling pathway.

Typhoid fever in pregnancy - a South Australian perspective.

Obstetric medicine

Knowledge and practices of traditional treatment of chicken diseases using medicinal plants by indigenous communities in Najjembe sub-county, Buikwe district central Uganda.

BMC veterinary research

Travel medicine and infectious disease

Ready for takeoff? exploring United States health care providers' pretravel consultation priorities, gaps, barriers, and opportunities.

Chemical and pharmacological richness of Turraeanthus (Meliaceae): A review on progress and future research opportunities.

Fitoterapia

The Science of the total environment

Association of typhoid fever with floods under climate variability in 82 Belt and Road Initiative countries (2000-2021): A mixed-effects model and implications for water and sanitation infrastructure.

Communicable diseases intelligence (2018)

Investigation of a Salmonella Typhi cluster among a Pacific Islander labour community in a fruit industry: perspective from a regional public health unit.

World journal of virology

Lassa fever: A comprehensive review of virology, clinical management, and global health implications.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

More than a fever: Encephalitis due to typhoid fever.

Emerging infectious diseases

Comparative Epidemiology of Salmonella enterica Serovers Paratyphi A and Typhi Causing Enteric Fever, Bangladesh, 2018-2020.

Immunogenicity and Safety Results of a Randomized, Three-Arm, Phase IV Clinical Trial of Concomitant Administration of Typhoid Vi Conjugate Vaccine with Measles and Rubella Vaccine in Healthy Infants.

Viruses

Mathematical modeling and analysis of COVID-19 and typhoid fever co-dynamics with treatment.

Internal medicine journal

Impact of lack of immunisation against diphtheria in the Australian military during the Second World War.

medRxiv : the preprint server for health sciences

A phase 1 randomized, placebo-controlled trial of a combination typhoid and non-typhoidal Salmonella polysaccharide conjugate vaccine.

Genomic profiling of enterotoxigenic Escherichia coli toxins and adhesins in livestock isolates from Kenya.

Microbial genomics

Pakistan journal of pharmaceutical sciences

The characteristic of antibiotic drug resistance of Salmonella Typhi isolated from tertiary care hospital in Faisalabad.

Concurrent fulminant type 1 diabetes and typhoid fever: A case report.

Medicine

Journal of medical microbiology

Heterogeneous Salmonella typhi transmission within a household: genomic insights from a chronic carrier.

Emerging insights into the type I secretion system: a key player in Salmonella virulence and host-pathogen interactions.

mBio

Antimicrobial agents and chemotherapy

Emergence of azithromycin and ciprofloxacin non-susceptible genotype 4.2.2 S. Typhi in Fiji.

FliC adjuvant augments protective efficacy of recombinant T2544 antigen against SalmonellaTyphiand Paratyphi A by increasing serum antibodies, intestinal secretory immunoglobulin A and T cell memory.

Journal of microbiological methods

Design and in silico evaluation of a novel chimeric protein vaccine candidate against Salmonella Typhi.

Temporal dynamics of macrophage activation during Salmonella enterica serovar Typhi infection: An integrated transcriptomic and metabolomic analysis.

Virulence

Health policy (Amsterdam, Netherlands)

Urgent action needed to address the epidemiological threat of prolonged war in Gaza.

WHO preferred product characteristics for bivalent Salmonella Typhi/Paratyphi A vaccine for comprehensive protection against enteric fever- key considerations and research gaps.

Gates open research

Longevity of immune-response provided by at least one dose of vi-DT vaccine 5 years after vaccination among healthy Filipino adults and children.

Archives of clinical and biomedical research

A Rare Concurrent Presentation of Typhoid Fever with Bacteremia and Pulmonary Tuberculosis.

The Journal of the Association of Physicians of India

Acute Cerebellar Ataxia in a Case of Enteric Fever.

Identification of OxyR as an activator of type 1 fimbriae (fim) in Salmonella enterica serovar Typhi.

Microbiology spectrum

Exploring Postoperative Outcomes of Primary Repair Versus Loop Ileostomy in Typhoid Ileal Perforation: A Systematic Review and Meta-Analysis.

Timeframe for suspecting typhoid fever post-travel in Canadian children.

CJEM

Integrated machine learning, molecular dynamics, and DFT-based approach to elucidate the inhibitory effect of Ciprofloxacin analogues against fluoroquinolone-resistant Salmonella Typhi.

Archives of microbiology

False positive results in the Widal test in adults immunized with the Commirnaty (Pfizer-BioNtech) and BBIBP-CorV (Sinopharm) vaccines against COVID-19.

Frontiers in medicine

Infectious disorders drug targets

The rise of Extended spectrum β-lactamase (ESBL) producing ceftriaxone resistant Salmonella Typhi from western Rajasthan, India.

Enteric (typhoid and paratyphoid) fever.

Lancet (London, England)

Safety and immunogenicity of the invasive non-typhoidal Salmonella (iNTS)-GMMA vaccine: a first-in-human, randomised, dose escalation trial.

EBioMedicine

Tropical medicine & international health : TM & IH

Cross-Reactivity of SARS-CoV-2 Antibodies With Typhoid Flagellar-H Protein.

Epidemiological Study of Dengue Fever in a Tertiary Care Hospital in Dera Ismail Khan, Pakistan.

Cytotoxic lesion of the corpus callosum (CLOCC) associated with typhoid fever: A case report.

Radiology case reports

Rational design of a multi epitope vaccine against Salmonella typhi via subtractive proteomics, reverse vaccinology and molecular modeling.

Extended drug-resistant Salmonella Typhi complicated by rare fatal haemophagocytic lymphohistocytosis: A case report.

Tropical doctor

The rose spots of typhoid fever: The story behind the eponym.

Clinics in dermatology

Bivalent Oral Vaccine Using Attenuated Salmonella Gallinarum Delivering HA and NA-M2e Confers Dual Protection Against H9N2 Avian Influenza and Fowl Typhoid in Chickens.

Vaccines

International journal of environmental research and public health

Health Inequalities in Primary Care: A Comparative Analysis of Climate Change-Induced Expansion of Waterborne and Vector-Borne Diseases in the SADC Region.

Ver todos os 10.387 no EuropePMC

S-Nitrosylation in Cardiovascular Disorders: The State of the Art.

Biomolecules

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Doenças relacionadas

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