Uma doença autoimune que leva à diminuição das plaquetas no sangue.
Introdução
O que você precisa saber de cara
Uma doença autoimune que leva à diminuição das plaquetas no sangue.
Tem tratamento?
Encontrou um erro ou informação desatualizada? Sugira uma correção →
Entender a doença
Do básico ao detalhe, leia no seu ritmo
Preparando trilha educativa...
Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 12 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 32 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
1 gene identificado com associação a esta condição.
Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells
CytoplasmCell membrane
Medicamentos e terapias
Mecanismo: Thrombopoietin receptor agonist
Mecanismo: Glucocorticoid receptor agonist
Mecanismo: Glucocorticoid receptor agonist
Mecanismo: Thrombopoietin receptor agonist
Mecanismo: Glucocorticoid receptor agonist
Mecanismo: Tyrosine-protein kinase SYK inhibitor
Mecanismo: Glucocorticoid receptor agonist
Mecanismo: DNA (cytosine-5)-methyltransferase 3A inhibitor
Mecanismo: B-lymphocyte antigen CD20 binding agent
Mecanismo: Glucocorticoid receptor agonist
Variantes genéticas (ClinVar)
12 variantes patogênicas registradas no ClinVar.
Classificação de variantes (ClinVar)
Distribuição de 2 variantes classificadas pelo ClinVar.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Trombocitopenia autoimune
Selecione um estado ou use sua localização para ver resultados.
Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
🟢 Recrutando agora
7 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.
Outros ensaios clínicos
516 ensaios clínicos encontrados, 9 ativos.
Publicações mais relevantes
STAT3R152W Mutation Model Reveals Temporal Changes in Hematopoietic Populations.
Inconsistent presentation of STAT3 variants in clinical settings makes them challenging to use in diagnostics and the prevention of unfavorable outcomes. Patients harboring the STAT3R152W variant display a range of autoimmune disorders, including type 1 diabetes, hemolytic anemia, and thrombocytopenia. Because of a complex interplay of genetic and environmental cofactors, it is difficult to discern the direct role STAT3 plays in the development of those conditions. Here, we report a mouse model of the STAT3R152W variant and describe its hematopoietic populations throughout adulthood. We observed profound changes in both innate and adaptive immunity, including increased splenic Th17 component consistent with a gain-of-function mutation, as described in the literature. At the same time, the mice did not develop obvious symptoms of autoimmunity. R152W mutants show lowered hemoglobin and hematocrit, indicating susceptibility to anemia, but also an increased number of thrombocytes, contradictory to reports of autoimmune thrombocytopenia. We showcase how those changes develop and wane in time, and the differences between male and female animals. Our findings paint the STAT3R152W variant as a cause of severe immune dysregulation, but only as a cofactor in the development of autoimmunity.
TNFAIP3 Gene Polymorphisms and the Risk of Thrombocytopenia: A Cross-Sectional Study in Iranian Population.
Thrombocytopenia, particularly immune thrombocytopenic purpura, is a prevalent hematological disorder characterized by low platelet counts, leading to increased bleeding risks. Genetic factors, including single nucleotide polymorphisms, are implicated in its pathogenesis. The TNFAIP3 gene, which encodes a negative regulator of inflammation, has been associated with various autoimmune diseases. This study investigates the association between TNFAIP3 polymorphisms (rs10499194 and rs2230926) and thrombocytopenia in an Iranian population. This cross-sectional study enrolled a total of 156 participants, including 40 patients diagnosed with non-immune thrombocytopenia, 38 patients with autoimmune thrombocytopenia, and 78 healthy controls. Genotyping of the TNFAIP3 rs10499194 and rs2230926 polymorphisms was done by employing the Tetra-primer Amplification Refractory Mutation System PCR technique. Genotype and allele frequencies were compared between groups. The frequencies of the CC, CT, and TT genotypes of the rs10499194 polymorphism in immune thrombocytopenia, non-immune thrombocytopenia, and healthy individuals were 63.2% (n = 24), 21.1% (n = 8), 15.8% (n = 6) for immune thrombocytopenia; 52.5% (n = 21), 27.5% (n = 11), and 20% (n = 8) for non-immune thrombocytopenia; and 76.9% (n = 60), 10.3% (n = 8), and 12.8% (n = 10) for healthy individuals, respectively. The CT and TT genotypes were significantly associated with an increased risk of thrombocytopenia (OR = 2.5, p = 0.02 for CT; OR = 1.8, p = 0.04 for TT). For rs2230926, all participants exhibited the TT genotype, with no variation observed. The lack of variation in rs2230926 is consistent with population databases, indicating low minor allele frequency in this region. The rs10499194 polymorphism is significantly associated with thrombocytopenia, particularly in non-immune cases, suggesting a potential genetic predisposition. The absence of variation in rs2230926 may reflect population-specific genetic homogeneity. Further studies with larger sample sizes are needed to confirm these findings and explore clinical implications.
Investigating the link between Helicobacter pylori infection and idiopathic thrombocytopenic purpura a case-control study.
Immune thrombocytopenic purpura (ITP) is an autoimmune disorder marked by isolated thrombocytopenia. Recent studies suggest a link between Helicobacter pylori (H. pylori) infection and ITP, possibly through molecular mimicry and immune-mediated mechanisms. This study aimed to investigate the association between H. pylori infection and ITP in a Pakistani population where both conditions are prevalent. A case-control study was conducted from May 2022 to June 2024 at a tertiary care hospital in Pakistan. A total of 141 participants were enrolled, including 46 patients with primary ITP and 95 age- and sex-matched controls without thrombocytopenia. All subjects were tested for H. pylori using stool antigen tests, urea breath tests, and confirmatory biopsies where applicable. Logistic regression was used to assess the association while adjusting for potential confounders. H. pylori infection was present in 39.1% of ITP patients compared to 17.9% of controls (P = 0.0026). The crude odds ratio (OR) was 2.96 (95% CI: 1.36-6.46), and the adjusted OR was 3.18 (95% CI: 1.42-7.13, P = 0.005) after controlling for age, gender, smoking, and socioeconomic status. Other variables were not significantly associated with ITP. A significant association between H. pylori infection and ITP was observed, supporting the need for routine screening in ITP patients, especially in endemic areas. Further studies should evaluate the platelet response after H. pylori eradication and assess the role of bacterial strain variability.
[Fasciitis-like primary breast pyoderma gangrenosum: A rare case report].
Pyoderma gangrenosum (PG) is a rare condition caused by dermal inflammation with neutrophilic infiltration, often associated with an underlying systemic disease. The breast is an uncommon site for this condition. It is an exclusion diagnosis, challenging to establish, which may initially lead to an alternative one and the initiation of inappropriate treatment. A 41-year-old woman with a medical history of morbid obesity, breast reduction 14 years ago, common variable immunodeficiency (CVID), and autoimmune thrombocytopenia presented with a spontaneous inflammatory ulcer of the left breast. The clinical course rapidly deteriorated, progressing to septic shock despite antibiotics. This presentation led to the consideration of necrotizing soft tissue infection (NSTI) as the primary diagnosis. The patient underwent multiple surgical debridements combined with broad- spectrum antibiotic therapy, which resulted in only a slow improvement in her condition. Histopathological examination of the surgical specimens revealed a cutaneous ulcer with dermal inflammation predominantly composed of neutrophils. Her condition eventually stabilized, allowing for reconstruction of the left breast with a split-thickness skin graft. In the immediate postoperative period, the patient developed a fever of unknown origin and inflammatory lesions with a violaceous border at the graft donor site. PG was suspected. One month later, the patient presented with a spontaneously occurring violaceous inflammatory lesion on the controlateral breast. This case of spontaneous PG, is a condition only very rarely described in the literature. A combination of concordant findings support this diagnosis. PG is a rare condition with a challenging diagnosis, as it is one of exclusion. The breast is an uncommon site of involvement, typically described in postoperative cases and very rarely presenting spontaneously. When a patient presents with breast dermo-hypodermitis that shows limited improvement despite appropriate treatment, PG should be considered as a differential diagnosis.
Pulmonary Embolism and Myocardial Infarction With Non-obstructive Coronary Arteries in Immune Thrombocytopenia: Unmasking Underlying Antiphospholipid Syndrome.
This case report presents the clinical scenario of a 35-year-old male patient who experienced chest pain due to a combination of pulmonary embolism (PE) and myocardial infarction with non-obstructive coronary arteries (MINOCA), concurrently while undergoing treatment with avatrombopag for immune thrombocytopenia (ITP). His investigations included a CT pulmonary angiogram that confirmed a PE, a coronary angiography which was normal, a cardiac MRI which showed evidence of subendocardial infarct, and a CT coronary angiogram, which was normal. His unique presentation with these findings prompted further investigations, which revealed an undiagnosed antiphospholipid syndrome (APS) alongside a patent foramen ovale (PFO). Hence, the paradoxical thrombotic incidents were precipitated by this unique diagnosis. After establishing the diagnosis, our patient was commenced on warfarin, and his treatment protocol for ITP was changed to a different drug. He remains under haematology follow-up.
Publicações recentes
Efficacy and Safety of Subcutaneous Efgartigimod PH20 in Adults With Primary Immune Thrombocytopenia (ADVANCE SC): A Multicenter, Randomized, Double-Blinded, Placebo-Controlled, Phase 3 Trial.
STAT3(R152W) Mutation Model Reveals Temporal Changes in Hematopoietic Populations.
Investigating the link between Helicobacter pylori infection and idiopathic thrombocytopenic purpura a case-control study.
[Fasciitis-like primary breast pyoderma gangrenosum: A rare case report].
Pulmonary Embolism and Myocardial Infarction With Non-obstructive Coronary Arteries in Immune Thrombocytopenia: Unmasking Underlying Antiphospholipid Syndrome.
📚 EuropePMC371 artigos no totalmostrando 157
STAT3R152W Mutation Model Reveals Temporal Changes in Hematopoietic Populations.
International journal of molecular sciencesInvestigating the link between Helicobacter pylori infection and idiopathic thrombocytopenic purpura a case-control study.
Annals of medicine and surgery (2012)[Fasciitis-like primary breast pyoderma gangrenosum: A rare case report].
Annales de chirurgie plastique et esthetiquePulmonary Embolism and Myocardial Infarction With Non-obstructive Coronary Arteries in Immune Thrombocytopenia: Unmasking Underlying Antiphospholipid Syndrome.
CureusTNFAIP3 Gene Polymorphisms and the Risk of Thrombocytopenia: A Cross-Sectional Study in Iranian Population.
Health science reportsDo CVID patients on SCIG have more autoimmune (thrombo)cytopenic events than CVID patients on IVIG?
Frontiers in immunologyAutoimmune Thrombocytopenia Treated by Low-Dose Splenic Irradiation Followed by Splenectomy in a Patient With Systemic Lupus Erythematosus.
Clinical case reportsInterferon-stimulated Viperin impairs Treg function in autoimmune thrombocytopenia.
Cell communication and signaling : CCSDysregulation of apolipoprotein o reprograms CCR7+CD4+T cell fate in primary autoimmune thrombocytopenia.
iScienceRecommendations of the AGG (Obstetrics and Prenatal Medicine Working Group, Section Maternal Diseases) on Maternal Thrombocytopenia in Pregnancy.
Geburtshilfe und Frauenheilkunde[Parvovirus B19 in Adolescents and Adults: A Case Series of Clinical Mimicry].
Acta medica portuguesaSevere Immune Thrombocytopenia Following Endovascular Aneurysm Repair: A Rare Case of Helicobacter pylori Infection and Probable Systemic Lupus Erythematosus.
CureusEfficacy and safety of dostarlimab in elderly patients with multiple comorbidities and allergic diathesis: case report.
AME case reportsSystemic Lupus Erythematosus with Refractory Immune Thrombocytopenia Progressing to Catastrophic Anti-Phospholipid Syndrome During Thrombopoietin Receptor Agonist Therapy: A Case Report.
Journal of clinical medicineThe paradox of autoimmune thrombocytopenia in common variable immunodeficiency.
British journal of haematologyRefractory thrombocytopenia as an initial presentation of childhood systemic lupus erythematosus and its response to rituximab.
BMJ case reportsConcurrent invasive disseminated Nocardia farcinica and Candida infections in a patient undergoing long-term glucocorticoid therapy for autoimmune thrombocytopenia: a case report.
BMC infectious diseasesAcute Intracerebral Hemorrhage Associated with Extensive Venous Thrombosis Due to Spontaneous Heparin-Induced Thrombocytopenia After Total Knee Replacement: A Case Report.
Hematology reportsNocardiosis in systemic lupus erythematosus patients treated with rituximab: Report of two cases and systematic review of literature.
LupusAutoimmune Thrombocytopenia in Pregnancy: Insights from an Uncommon Case Presentation and Mini-Review.
Journal of clinical medicineImmune Reconstitution Inflammatory Syndrome-Induced Thrombocytopenia in a Patient With HIV and Coccidioidomycosis.
CureusAssociation of HPA Antigens with Immune Thrombocytopenia: A Case-Control Study by PCR-SSP Method.
International journal of hematology-oncology and stem cell researchClonal hematopoiesis in patients with autoimmune thrombocytopenia: an international multicenter study.
Blood advancesFactors predictive of severe thrombocytopenia and its impact on poor outcomes in Latin American patients with systemic lupus erythematosus: Data from a multiethnic Latin American cohort.
Seminars in arthritis and rheumatismRefractory Autoimmune Thrombocytopenia in an Infant with a De Novo TLR7 Gain-of-Function Variant.
Journal of clinical immunologyEpidural blood patching in an anticoagulated patient with intracranial hypotension.
Practical neurologyCatastrophic Antiphospholipid Syndrome: A Life-Threatening Condition.
CureusWhole Exome Sequencing in Vaccine-Induced Thrombotic Thrombocytopenia (VITT).
BioMed research internationalComplications of Brentuximab Therapy in Patients with Hodgkin's Lymphoma and Concurrent Autoimmune Pathology-A Case Series.
Hematology reportsSuccessful kidney transplantation from a live donor with immune thrombocytopenia: a case report.
Clinical transplantation and researchThe Interplay between Helicobacter pylori and Gut Microbiota in Non-Gastrointestinal Disorders: A Special Focus on Atherosclerosis.
International journal of molecular sciencesAutoimmune Heparin-Induced Thrombocytopenia.
Journal of clinical medicineMycophenolate mofetil for autoimmune cytopenias in children: high rates of response in inborn errors of immunity.
Frontiers in pediatricsAutoimmune Heparin-Induced Thrombocytopenia: A Diagnostic and Management Challenge After Transcatheter Aortic Valve Replacement.
CureusPunctate inner choroidopathy in common variable immunodeficiency associated with a pathogenic variant in the tumour necrosis factor receptor superfamily 13b (TNFRSF13B) gene - Case report and review of the literature.
Clinical immunology (Orlando, Fla.)Acalabrutinib and steroid for autoimmune thrombocytopenia due to relapsed chronic lymphocytic leukemia with severe bone marrow infiltration.
Journal of clinical and experimental hematopathology : JCEHMassive Right Chylothorax Secondary to a Severe Systemic Lupus Erythematosus Flare With Secondary Evans Syndrome: A Case Report and Literature Review.
Clinical medicine insights. Case reportsReal-life use of mTOR inhibitor-based therapy in adults with autoimmune cytopenia highlights strong efficacy in relapsing/refractory multi-lineage autoimmune cytopenia.
Annals of hematology[Wiskott-Aldrich syndrome with platelets of normal size and c.295C>T mutation of the WAS gene. Case report].
Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)Evans Syndrome as a Possible Complication of Brentuximab Vedotin Therapy for Peripheral T Cell Lymphoma.
Hematology reportsAssociations between bullous pemphigoid and hematological diseases: Literature review on mechanistic connections and possible treatments.
Frontiers in immunologyCOVID-19: A trigger of autoimmune diseases.
Cell biology internationalDaratumumab as a novel treatment option in refractory ITP.
Blood cells, molecules & diseasesA Rare Central Nervous System Involvement Due to CTLA-4 Gene Defect.
Noro psikiyatri arsiviParaneoplastic syndromes: A focus on pathophysiology and supportive care.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System PharmacistsImmune-Mediated Neonatal Thrombocytopenia.
NeoReviewsPediatric Evans Syndrome: A 20-year experience from a tertiary center in Brazil.
Hematology, transfusion and cell therapy[Non-malignant, non-infectious lymphoproliferation: challenges in the diagnosis and treatment of autoimmune lymphoproliferative syndrome].
Orvosi hetilapAutoimmune Cytopenias and Dysregulated Immunophenotype Act as Warning Signs of Inborn Errors of Immunity: Results From a Prospective Study.
Frontiers in immunologyAutoimmune Thrombocytopenia in SLE and COVID-19.
European journal of case reports in internal medicineSevere neonatal autoimmune thrombocytopenia secondary to maternal Evans syndrome.
BMJ case reportsRegional Hypertonic Citrate Anticoagulation in Membrane Therapeutic Plasma Exchange: A Case Series.
Canadian journal of kidney health and diseaseFirst Report of Severe Autoimmune Hemolytic Anemia During Eltrombopag Therapy in Waldenström Macroglobulinemia-Associated Thrombocytopenia.
OncoTargets and therapyCharacterization of molecular genetics and clinicopathology in thymic MALT lymphoma.
Annals of hematologyThe presence of idiopathic thrombocytopenic purpura and incidence of acute non-ST elevation myocardial infarction.
Annals of hematologyIL-23/Th17 pathway and IL-17A gene polymorphism in Egyptian children with immune thrombocbytopenic purpura.
Italian journal of pediatricsKinetics of platelet adhesion to a fibrinogen-coated surface in whole blood under flow conditions.
Journal of clinical laboratory analysisRoxithromycin-Associated Acute Thrombocytopenia.
The American journal of case reportsCOVID-19 Vaccine and Death: Causality Algorithm According to the WHO Eligibility Diagnosis.
Diagnostics (Basel, Switzerland)Coronavirus Disease 2019 and Cold Agglutinin Syndrome: An Interesting Case.
European journal of case reports in internal medicineCase Report: Hypomorphic Function and Somatic Reversion in DOCK8 Deficiency in One Patient With Two Novel Variants and Sclerosing Cholangitis.
Frontiers in immunologyEltrombopag Effectiveness and Tolerability in Chronic Immune Thrombocytopenia: A Meta-Analysis.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisThrombocytopenia: Effect in Ischemic and Hemorrhagic Stroke.
Dimensions of critical care nursing : DCCNSurgical stabilization of severe flail chest with Judet and Sanchez-Lloret plates. A case report.
International journal of surgery case reportsCharacterization of glycoprotein IIb/IIIa-specific alloantibodies induced by cross-strain platelet immunization in mice.
TransfusionTreatment of severe thrombocytopenia associated with systemic lupus erythematosus in pregnancy with eltrombopag: A case report and literature review.
Journal of clinical pharmacy and therapeuticsA patient with Gaucher disease and plasma cell dyscrasia: bidirectional impact.
Hematology. American Society of Hematology. Education ProgramMeasuring parent proxy-reported quality of life of 11 rare diseases in children in Zhejiang, China.
Health and quality of life outcomesTwo Cases of Autoimmune Neutropenia Complicated with Other Lineages of Autoimmune Cytopenia, Successfully Treated with Prednisolone.
Internal medicine (Tokyo, Japan)Acute Kidney Injury Caused by Evans Syndrome with Systemic Lupus Erythematosus and Systemic Sclerosis.
Internal medicine (Tokyo, Japan)The impact of autoimmune cytopenias on the clinical course and survival of Hodgkin lymphoma.
International journal of hematologyTreatment outcomes and chronicity predictors for primary immune thrombocytopenia: 10-year data from an academic center.
Annals of hematologyLow-dose rituximab therapy in steroid-refractory thrombocytopenia due to systemic lupus erythematosus.
Rheumatology internationalUse of obinutuzumab for refractory autoimmune thrombocytopenia secondary to CLL.
EJHaemIdiopathic thrombocytopenic purpura is strongly associated with higher prevalence of aortic valve disease.
Annals of hematologyMonogenic lupus due to spondyloenchondrodysplasia with spastic paraparesis and intracranial calcification: case-based review.
Rheumatology internationalPathogenesis of immune thrombocytopenia in common variable immunodeficiency.
Autoimmunity reviewsComplement activation in patients with immune thrombocytopenic purpura according to phases of disease course.
Clinical and experimental immunologyA Case of Evans Syndrome with Acute Hemolysis and Hemoglobin Cast Nephropathy.
The American journal of case reportsRituximab treatment for dermatitis herpetiformis in the setting of type 1 diabetes mellitus, celiac disease, vitiligo, autoimmune hemolytic anemia, and autoimmune thrombocytopenia.
JAAD case reportsMikulicz's Disease With Immune Thrombocytopenia: A New Immunoglobulin G4-Mediated Disorder and Literature Review.
Archives of rheumatologyFatty Liver and Autoimmune Hepatitis: Two Forms of Liver Involvement in Lipodystrophies.
GE Portuguese journal of gastroenterologyAutoimmune thrombocytopenia: Current treatment options in adults with a focus on novel drugs.
European journal of haematologyVitamin D supplementation for the prevention or depletion of side effects of therapy with alemtuzumab in multiple sclerosis.
Therapeutics and clinical risk managementPredictors for Autoimmune Cytopenias after Allogeneic Hematopoietic Cell Transplantation in Children.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow TransplantationA Rare Case of Multiple Myeloma Presenting as Evan's Syndrome.
Journal of investigative medicine high impact case reportsLow percentages of regulatory T cells in common variable immunodeficiency (CVID) patients with autoimmune diseases and its association with increased numbers of CD4+CD45RO+ T and CD21low B cells.
Allergologia et immunopathologiaImmunodeficiency, autoimmune thrombocytopenia and enterocolitis caused by autosomal recessive deficiency of PIK3CD-encoded phosphoinositide 3-kinase δ.
HaematologicaGlucocorticoids promote response to thrombopoietin-receptor agonists in refractory ITP: a case series.
International journal of hematologyPathophysiology of Autoimmune Thrombocytopenia: Current Insight with a Focus on Thrombopoiesis.
HamostaseologieHemoperitoneum after Ovulation in Systemic Lupus Erythematosus and Autoimmune Thrombocytopenia.
Case reports in obstetrics and gynecologyAllergic Contact Dermatitis, Angioneurotic Edema and Conjunctivitis in a Patient with Autoimmune Thrombocytopenia - A Clinical Case.
Open access Macedonian journal of medical sciencesThe Association Between Human Leukocyte Antigens and ITP, TTP, and HIT.
Journal of pediatric hematology/oncologyInfundibuloneurohypophysitis associated with autoimmune thrombocytopenia and chiasmal syndrome: a case report.
Acta neurologica BelgicaFollicular Helper T Cells in DiGeorge Syndrome.
Frontiers in immunologyWeekly Rituximab Followed by Monthly Rituximab Treatment for Autoimmune Disease Associated With RAS-associated Autoimmune Leukoproliferative Disease.
Journal of pediatric hematology/oncologyIs It Safe to Switch From Intravenous Immunoglobulin to Subcutaneous Immunoglobulin in Patients With Common Variable Immunodeficiency and Autoimmune Thrombocytopenia?
Frontiers in immunologyAutoimmune haemolytic anaemia and autoimmune thrombocytopenia in childhood-onset systemic lupus erythematosus: updates on pathogenesis and treatment.
Current opinion in rheumatologyEvans Syndrome After Successful Immunosuppressant-Free Living-Donor Liver Transplant.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ TransplantationEvaluation of Clinical and Immunological Characteristics of Children with Common Variable Immunodeficiency.
International journal of pediatricsAtypical Autoimmune Hematologic Disorders in a Patient With Kabuki Syndrome.
Journal of pediatric hematology/oncologyIntracranial Hemorrhage and Autoimmune Thrombocytopenia in a Neonate: A Rare "Unpredictable" Event.
Child neurology openAdult-onset primary cyclic autoimmune neutropenia: a case report.
Transfusion[X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection, and neoplasia: report of a family and literature review].
Zhonghua er ke za zhi = Chinese journal of pediatricsSplenectomy in systemic lupus erythematosus and autoimmune hematologic disease: a comparative analysis.
Clinical rheumatologyExpanding the Phenotype of ALK-positive Histiocytosis: A Report of 2 Cases.
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology SocietyRe: Severe Primary Autoimmune Thrombocytopenia (ITP) in Pregnancy: a national cohort study Primary immune thrombocytopenia management during pregnancy. A French study.
BJOG : an international journal of obstetrics and gynaecologyMaternal autoimmune disorders and fetal defects.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal ObstetriciansGPIIb/IIIa autoantibody predicts better rituximab response in ITP.
British journal of haematologyClinical and serological autoimmune complications in chronic lymphocytic leukemia.
Wiener klinische WochenschriftClinical and Laboratory Features of CD5-Negative Chronic Lymphocytic Leukemia.
Medical science monitor : international medical journal of experimental and clinical researchSevere primary autoimmune thrombocytopenia in pregnancy: a national cohort study.
BJOG : an international journal of obstetrics and gynaecologyThymus transplantation for complete DiGeorge syndrome: European experience.
The Journal of allergy and clinical immunologyIs Autoimmune Thrombocytopenia Itself the Primary Disease in the Presence of Second Diseases Data from a Long-Term Observation.
Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und ImmunhamatologieThrombotic thrombocytopenic purpura misdiagnosed as autoimmune cytopenia: Causes of diagnostic errors and consequence on outcome. Experience of the French thrombotic microangiopathies reference centre.
American journal of hematologyIntravenous Immunoglobulin in Pediatric Rheumatology: When to Use It and What Is the Evidence.
Pediatric annals[Clinical and immunological analysis of the patient with autoimmunity due to germline STAT3 gain-of-function mutation].
Zhonghua er ke za zhi = Chinese journal of pediatricsNew aspects on the efficacy of high-dose intravenous immunoglobulins in patients with autoimmune thrombocytopenia.
Vox sanguinisPolymorphisms in NAT2 (N-acetyltransferase 2) gene in patients with systemic lupus erythematosus.
Revista brasileira de reumatologiaAutoimmune Cytopenias: Diagnosis & Management.
Rhode Island medical journal (2013)An atypical case of late-onset systemic lupus erythematosus with systemic lymphadenopathy and severe autoimmune thrombocytopenia/neutropenia mimicking malignant lymphoma.
International journal of hematologyClinical Features of Patients with Castleman's Disease Complicated Systemic Lupus Erythematosus.
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae SinicaeThrombopoietin Receptor Agonists Are Often Ineffective in Immune Thrombocytopenia and/or Cause Adverse Reactions: Results from One Hand.
Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und ImmunhamatologieSulfasalazine induced immune thrombocytopenia in a patient with rheumatoid arthritis.
Clinical rheumatologyIn vivo effector functions of high-affinity mouse IgG receptor FcγRI in disease and therapy models.
Journal of autoimmunityMulticentre, randomised phase III study of the efficacy and safety of eltrombopag in Chinese patients with chronic immune thrombocytopenia.
British journal of haematologyChildhood-onset autoimmune cytopenia as the presenting feature of biallelic ACP5 mutations.
Pediatric blood & cancerAnti-Interleukin-6 Receptor Tocilizumab for Severe Juvenile Idiopathic Arthritis-Associated Uveitis Refractory to Anti-Tumor Necrosis Factor Therapy: A Multicenter Study of Twenty-Five Patients.
Arthritis & rheumatology (Hoboken, N.J.)Neuromyelitis optica spectrum disorder coinciding with hematological immune disease: A case report.
Multiple sclerosis and related disordersSelf-administered hyaluronidase-facilitated subcutaneous immunoglobulin therapy in complicated primary antibody deficiencies.
ImmunotherapyLong-Term Outcomes of Hematopoietic Stem Cell Transplantation for ZAP70 Deficiency.
Journal of clinical immunologyAutoimmunity and infection in common variable immunodeficiency (CVID).
Autoimmunity reviewsDecreased function of Fas and variations of the perforin gene in adult patients with primary immune thrombocytopenia.
British journal of haematologyOverlap of IgG4-related Disease and Primary Biliary Cirrhosis Complicated with Autoimmune Thrombocytopenia.
Internal medicine (Tokyo, Japan)LRBA deficiency with autoimmunity and early onset chronic erosive polyarthritis.
Clinical immunology (Orlando, Fla.)Efficacy of abatacept in systemic lupus erythematosus: a retrospective analysis of 11 patients with refractory disease.
Lupus[A case of human immunodeficiency virus infection with cerebellar ataxia that suggested by an association with autoimmunity].
Rinsho shinkeigaku = Clinical neurologySpondyloenchondrodysplasia Due to Mutations in ACP5: A Comprehensive Survey.
Journal of clinical immunologyPlatelet proteomics in diagnostic differentiation of primary immune thrombocytopenia using SELDI-TOF-MS.
Clinica chimica acta; international journal of clinical chemistryFetal and neonatal alloimmune thrombocytopenia.
Seminars in fetal & neonatal medicineRefractory Immunological Thrombocytopenia Purpura and Splenectomy in Pregnancy.
Case reports in immunologyRomiplostim for the treatment of glioblastoma-related paraneoplastic autoimmune thrombocytopenia refractory to conventional therapy.
Annals of hematologyAutoimmune Thrombocytopenia Complicated by EDTA- and/or Citrate-Dependent Pseudothrombocytopenia.
Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und ImmunhamatologieThe Differential Diagnosis of Thrombocytopenia in Pregnancy.
Deutsches Arzteblatt international[Diagnosis of inherited thrombocytopenia].
La Revue de medecine interneSuccessful Treatment with Rituximab in a Patient with Castleman's Disease Complicated by Systemic Lupus Erythematosus and Severe Autoimmune Thrombocytopenia.
Chinese medical journalEfficacy and Safety of Rituximab in Systemic Lupus Erythematosus and Sjögren Syndrome Patients With Refractory Thrombocytopenia: A Retrospective Study of 21 Cases.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseasesVenous thromboembolism related to warm autoimmune hemolytic anemia: a case-control study.
Autoimmunity reviewsSevere immune thrombocytopenia after peg-interferon-alpha2a, ribavirin and telaprevir treatment completion: A case report and systematic review of literature.
World journal of hepatologySulfamethoxazole-induced thrombocytopenia masquerading as posttransfusion purpura: a case report.
TransfusionResolution of paraneoplastic immune thrombocytopenia following everolimus treatment for metastatic renal cell carcinoma.
Internal medicine journalIn vitro thromboelastometric evaluation of the efficacy of frozen platelet transfusion.
Thrombosis researchRituximab therapy has a rapid and durable response for refractory cytopenia in childhood-onset systemic lupus erythematosus.
LupusAntibody binding to megakaryocytes in vivo in patients with immune thrombocytopenia.
European journal of haematologyAutoimmune thrombocytopenia: a complication of fludarabine therapy in the treatment of Waldenstrom's macroglobulinemia.
International journal of clinical and experimental medicineSteroid-resistant autoimmune thrombocytopenia in systemic lupus erythematosus treated with rituximab.
Indian journal of dermatologyWilson disease with thrombocytopenia (case report).
Georgian medical newsAssociações
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Ainda não existe comunidade no Raras para Trombocitopenia autoimune
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- STAT3R152W Mutation Model Reveals Temporal Changes in Hematopoietic Populations.
- TNFAIP3 Gene Polymorphisms and the Risk of Thrombocytopenia: A Cross-Sectional Study in Iranian Population.
- Investigating the link between Helicobacter pylori infection and idiopathic thrombocytopenic purpura a case-control study.
- [Fasciitis-like primary breast pyoderma gangrenosum: A rare case report].
- Pulmonary Embolism and Myocardial Infarction With Non-obstructive Coronary Arteries in Immune Thrombocytopenia: Unmasking Underlying Antiphospholipid Syndrome.
- Efficacy and Safety of Subcutaneous Efgartigimod PH20 in Adults With Primary Immune Thrombocytopenia (ADVANCE SC): A Multicenter, Randomized, Double-Blinded, Placebo-Controlled, Phase 3 Trial.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:71203(Orphanet)
- MONDO:0019098(MONDO)
- Purpura Trombocitopenica Idiopatica(PCDT · Ministério da Saúde)
- GARD:18906(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Q55788483(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
