O carcinoma diferenciado da tireoide (CDT), também conhecido como carcinoma papilar ou folicular da tireoide, é uma doença maligna de crescimento lento que geralmente se apresenta em adultos como uma massa tireoidiana assintomática.
Introdução
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O carcinoma diferenciado da tireoide (CDT), também conhecido como carcinoma papilar ou folicular da tireoide, é uma doença maligna de crescimento lento que geralmente se apresenta em adultos como uma massa tireoidiana assintomática.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 12 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 32 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
33 genes identificados com associação a esta condição. Padrão de herança: Not applicable.
Involved in the activation of Ras protein signal transduction (PubMed:22821884). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:12740440, PubMed:14500341, PubMed:9020151)
Cell membraneGolgi apparatusGolgi apparatus membraneNucleusCytoplasmCytoplasm, perinuclear region
Costello syndrome
A rare condition characterized by prenatally increased growth, postnatal growth deficiency, intellectual disability, distinctive facial appearance, cardiovascular abnormalities (typically pulmonic stenosis, hypertrophic cardiomyopathy and/or atrial tachycardia), tumor predisposition, skin and musculoskeletal abnormalities.
Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/proge
Nucleus
Cargo receptor for the autophagic turnover of the iron-binding ferritin complex, playing a central role in iron homeostasis (PubMed:25327288, PubMed:26436293). Acts as an adapter for delivery of ferritin to lysosomes and autophagic degradation of ferritin, a process named ferritinophagy (PubMed:25327288, PubMed:26436293). Targets the iron-binding ferritin complex to autolysosomes following starvation or iron depletion (PubMed:25327288). Ensures efficient erythropoiesis, possibly by regulating he
Cytoplasmic vesicle, autophagosomeAutolysosomeNucleusChromosome
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:27626371). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:27626371). Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Preve
Mitochondrion inner membraneNucleus
Hurthle cell thyroid carcinoma
A rare type of thyroid cancer accounting for only about 3-10% of all differentiated thyroid cancers. These neoplasms are considered a variant of follicular carcinoma of the thyroid and are referred to as follicular carcinoma, oxyphilic type.
GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42
Thyroid cancer, non-medullary, 2
A form of non-medullary thyroid cancer (NMTC), a cancer characterized by tumors originating from the thyroid follicular cells. NMTCs represent approximately 95% of all cases of thyroid cancer and are classified into papillary, follicular, Hurthle cell, and anaplastic neoplasms.
Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon (PubMed:9732867). This protein enhances formation of the cap-proximal complex (PubMed:9732867). Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes (PubM
Cytoplasm
E3 ubiquitin-protein ligase that mediates ubiquitination of various substrates and thereby plays a role in diffent processes including proliferation, innate immunity, apoptosis, immune response or autophagy (PubMed:22829933, PubMed:24144979, PubMed:29688809, PubMed:36111389). Ubiquitinates PIK3C2B and inhibits its activity by mediating the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAG
NucleusCytoplasmNucleus, PML bodyEarly endosomeMitochondrion
Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand (PubMed:1281417, PubMed:15488758, PubMed:17196528, PubMed:1849459, PubMed:1850821, PubMed:22649032, PubMed:27445338, PubMed:8325889). Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axon
Cell membraneEarly endosome membraneLate endosome membraneRecycling endosome membrane
Congenital insensitivity to pain with anhidrosis
Characterized by a congenital insensitivity to pain, anhidrosis (absence of sweating), absence of reaction to noxious stimuli, self-mutilating behavior, and intellectual disability. This rare autosomal recessive disorder is also known as congenital sensory neuropathy with anhidrosis or hereditary sensory and autonomic neuropathy type IV or familial dysautonomia type II.
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1-alkenyl-LPA
Cell membrane
Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene exp
Nucleus
Chorea, hereditary benign
A rare autosomal dominant movement disorder, defined by early onset in childhood, a stable or non-progressive course of chorea, and no mental deterioration. Chorea is characterized by involuntary, forcible, rapid, jerky movements that may be subtle or become confluent, markedly altering normal patterns of movement.
Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system (PubMed:11121404, PubMed:11387242, PubMed:16317043, PubMed:17274988, PubMed:30061385, PubMed:34646012, PubMed:34819673). Also acts as a key thinness protein involved in the resistance to weight gain: in hypothalamic neurons, controls energy expenditure acting as a nega
Cell membrane
Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; i
NucleusNucleus membraneNucleus envelopeNucleus, nuclear pore complexCytoplasmCytoplasm, cytoskeleton, spindleChromosome, centromere, kinetochore
Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells
Nucleus
Hypothyroidism, congenital, non-goitrous, 2
A disease characterized by thyroid dysgenesis, the most frequent cause of congenital hypothyroidism, accounting for 85% of case. The thyroid gland can be completely absent (athyreosis), ectopically located and/or severely hypoplastic. Ectopic thyroid gland is the most frequent malformation, with thyroid tissue being found most often at the base of the tongue.
Required for centrosome assembly and function (PubMed:12403812, PubMed:15659651, PubMed:16943179). Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2 (PubMed:12403812, PubMed:15659651). Required to anchor microtubules to the centrosome (PubMed:12403812, PubMed:15659651). Also involved in cilium biogenesis by recruiting the BBSome, a ciliary protein complex involved in cilium biogenesis, to the centriolar satellites (PubMed:20551181, PubM
Cytoplasm, cytoskeletonCytoplasm, cytoskeleton, microtubule organizing center, centrosomeCytoplasmic granuleCytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satelliteCytoplasm, cytoskeleton, cilium basal body
Multiple inositol polyphosphate phosphatase that hydrolyzes 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (InsP5[2OH]) and 1D-myo-inositol hexakisphosphate (InsP6) to a range of less phosphorylated inositol phosphates. This regulates the availability of these various small molecule second messengers and metal chelators which control many aspects of cell physiology (PubMed:33257696, PubMed:36589890). Has a weak in vitro activity towards 1D-myo-inositol 1,4,5-trisphosphate which is unlikely to be ph
Endoplasmic reticulum lumenSecretedCell membrane
Thyroid cancer, non-medullary, 2
A form of non-medullary thyroid cancer (NMTC), a cancer characterized by tumors originating from the thyroid follicular cells. NMTCs represent approximately 95% of all cases of thyroid cancer and are classified into papillary, follicular, Hurthle cell, and anaplastic neoplasms.
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:20949621, PubMed:39809765). Plays an important role in the regulation of cell proliferation (PubMed:22711838, PubMed:23698361). Activates MAPK1/MAPK3 resulting in phosphorylation and ultimately degradation of GJA1 (By similarity). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (PubMed:24623306)
Cell membraneEndomembrane systemCytoplasm, cytosol
Leukemia, acute myelogenous
A subtype of acute leukemia, a cancer of the white blood cells. AML is a malignant disease of bone marrow characterized by maturational arrest of hematopoietic precursors at an early stage of development. Clonal expansion of myeloid blasts occurs in bone marrow, blood, and other tissue. Myelogenous leukemias develop from changes in cells that normally produce neutrophils, basophils, eosinophils and monocytes.
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-de
Nucleus, nucleolusNucleus, nucleoplasmNucleusChromosome, telomereCytoplasmNucleus, PML body
Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly (PubMed:11217080). It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form (PubMed:10754382, PubMed:11217080). Activates coagulation factor VII (
Secreted
Thyroid cancer, non-medullary, 5
A form of non-medullary thyroid cancer (NMTC), a cancer characterized by tumors originating from the thyroid follicular cells. NMTCs represent approximately 95% of all cases of thyroid cancer and are classified into papillary, follicular, Hurthle cell, and anaplastic neoplasms.
Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation in response to glia cell line-derived growth family factors (GDNF, NRTN, ARTN, PSPN and GDF15) (PubMed:20064382, PubMed:20616503, PubMed:20702524, PubMed:21357690, PubMed:21454698, PubMed:24560924, PubMed:28846097, PubMed:28846099, PubMed:28953886, PubMed:31118272). In contrast to most receptor tyrosine kinases, RET requires not onl
Cell membraneEndosome membrane
Hirschsprung disease 1
A disorder of neural crest development characterized by absence of enteric ganglia along a variable length of the intestine. It is the most common cause of congenital intestinal obstruction. Early symptoms range from complete acute neonatal obstruction, characterized by vomiting, abdominal distention and failure to pass stool, to chronic constipation in the older child.
CytoplasmCytoplasm, cytoskeleton
Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation
Nucleus
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity
Cell membraneGolgi apparatus membrane
Leukemia, juvenile myelomonocytic
An aggressive pediatric myelodysplastic syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes, rashes, and hemorrhages.
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560) Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability
Nucleus
Ovarian dysgenesis 8
An autosomal dominant form of ovarian dysgenesis, a disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads.
Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:21478858)
Endoplasmic reticulum
Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation
Membrane
Ligand-activated transcription factor that forms obligate heterodimers with the retinoic acid receptor and acts as a key regulator of biological processes, such as adipocyte differentiation, lipid metabolism, glucose homeostasis and beta-oxidation of fatty acids (PubMed:16150867, PubMed:20829347, PubMed:23525231, PubMed:8702406, PubMed:8706692, PubMed:9065481). Activated by lipid ligands: binds peroxisome proliferators, such as hypolipidemic drugs, and fatty acids, such as prostaglandin J2 metab
NucleusCytoplasm
Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor. Also implicated in thyroid gland morphogenesis. May indirectly play a role in cell growth and migration through the regulation of WNT5A expression
Nucleus
Bamforth-Lazarus syndrome
An autosomal recessive disease characterized by congenital hypothyroidism due to thyroid agenesis or thyroid hypoplasia, cleft palate, spiky hair, with or without choanal atresia, and bifid epiglottis.
Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179)
NucleusCytoplasmCell membrane
Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport
Cytoplasm, cytoskeleton, microtubule organizing center, centrosomeCytoplasmMembraneGolgi apparatus membranePresynaptic cell membraneCell projection, podosome
Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport
Golgi apparatus membrane
Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM
NucleusCytoplasmMitochondrion
Medicamentos aprovados (FDA)
1 medicamento encontrado nos registros da FDA americana.
Variantes genéticas (ClinVar)
225 variantes patogênicas registradas no ClinVar.
Vias biológicas (Reactome)
174 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Carcinoma da tireoide diferenciado
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Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
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Outros ensaios clínicos
207 ensaios clínicos encontrados, 35 ativos.
Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 1.990
The molecular mechanisms and potential therapeutic implications of the crosstalk between DNA methylation and metabolic reprogramming in thyroid cancer.
One of the fastest-growing malignant tumors in the world is thyroid cancer (TC), and there are currently no effective treatments for its aggressive subtypes, such as anaplastic carcinoma and radioactive iodine-refractory differentiated thyroid carcinoma. Recent investigations have shown that DNA methylation and metabolic reprogramming are not independent events, but rather create a closely interconnected, mutually reinforcing network of carcinogenic processes. On the one hand, metabolic reprogramming influences the methylation status of tumor suppressor genes and thyroid function genes by dynamically regulating the activity of DNA methyltransferases and demethylases through important metabolites (such as S-adenosylmethionine, or SAM, and α-KG) and oncogenic signaling pathways (like PI3K/AKT). Conversely, DNA methylation systematically remodels cellular glucose, lipid, and amino acid metabolism by directly silencing metabolic enzyme genes (such as FASN and GLS) and thyroid differentiation markers (such as NIS) to fulfill its proliferative demands. Tumor growth, treatment resistance, and the development of an immunosuppressive microenvironment are all fueled by this ongoing bidirectional interaction, which creates a self-reinforcing oncogenic cycle. As a result, the limitations of earlier discrete debates on DNA methylation or metabolic reprogramming are overcome in this review. To methodically clarify their crosstalk mechanisms, a theoretical framework based on the "DNA methylation-metabolism axis" is suggested. Additionally, it suggests multimodal therapy approaches that focus on this axis. Incorporating biomimetic delivery technologies, combined with epigenetic, metabolic, and immunotherapies, to lay the groundwork for comprehending TC causes and creating targeted treatments.
The Role of 123I in the Management of Differentiated Thyroid Cancer: A Comprehensive Narrative Review.
Differentiated thyroid carcinoma (DTC) is the most common malignant endocrine tumor, with a generally favorable prognosis. Imaging, including iodine radioactive isotope scintigraphy (IRIS), is crucial for diagnosis and follow-up. While 131I has long been used for both therapeutic and diagnostic purposes, 123I is reserved for diagnostic imaging due to its shorter half-life and γ emissions. This review highlights the utility of 123I scintigraphy, especially in pre-treatment assessment and dosimetry for DTC. It is particularly valuable before radioiodine (RAI) ablation, providing accurate imaging in patients with iodine-refractory (IR) or biochemically incomplete response (BIR) DTC. When compared to post-therapeutic 131I scans, 123I scintigraphy appears to have a lower sensitivity for detecting metastatic lesions, particularly in lymph nodes and lungs. However, its diagnostic performance compared to low-dose diagnostic 131I is more variable, with some studies suggesting superiority due to the absence of stunning. Further research is needed to standardize its use and optimize its role in guiding DTC management.
Multiomics Profiling Reveals Distinct Immunosuppression and Metabolic Dysregulation in Aggressive Subtypes of Thyroid Cancer.
Thyroid cancer comprises a heterogeneous group of malignancies with distinct clinical outcomes and molecular features, including papillary thyroid carcinoma (PTC), poorly differentiated thyroid carcinoma (PDTC), and anaplastic thyroid carcinoma (ATC). This study aimed to delineate the molecular and immune landscapes of these subtypes and identify potential biomarkers for the aggressive forms, ATC and PDTC. We assembled a well-annotated cohort of 120 formalin-fixed paraffin-embedded samples, including 35 ATC, 18 PDTC, 37 PTC cases, and 30 adjacent normal tissues (N) paired with PTC, collected over the past decade from multiple hospitals. To our knowledge, this represents the largest clinical ATC/PDTC cohort subjected to multiomics profiling and the first comprehensive proteomic analysis of these aggressive thyroid cancers. Using 4D-data-independent acquisition proteomics on 118 tumors (ATC 34, PDTC 18, PTC 36, and N 30), integrated with total RNA-seq on 69 samples (ATC 10, PDTC 5, PTC 31, and N 23), we revealed substantial molecular similarities between ATC and PDTC, both markedly distinct from PTC and adjacent normal tissues. ATC and PDTC exhibited significant enrichment in immune-related and metabolic pathways, with transcriptomic data indicating aggressive phenotypes and pronounced immunosuppression. Distinct immune landscapes of ATC and PDTC were revealed with neutrophil extracellular trap formation and M0 macrophage accumulation as key immunosuppressive mechanisms. Notably, Fc fragment of IgG receptor IIa (CD32) was identified as a promising biomarker for ATC, implicating a functional link between immune evasion and tumor aggressiveness. Our findings provide a comprehensive molecular and immunological characterization of thyroid cancer subtypes, offering novel insights into the pathogenesis of ATC and PDTC, and identifying potential targets for diagnosis and precision therapy.
Case Report: Lorlatinib for the treatment of ALK-rearranged poorly differentiated thyroid carcinoma after progression to prior ALK-specific tyrosine-kinase inhibitor.
ALK rearrangements are rare but actionable oncogenic drivers in thyroid cancer, particularly in aggressive histologies such as poorly differentiated thyroid carcinoma (PDTC), and evidence supporting sequential ALK inhibition in this setting is scarce. We report a 19-year-old male with ALK-rearranged, radioiodine-refractory PDTC who started systemic therapy with ceritinib, achieving a complete metabolic response. After treatment discontinuation and subsequent progression despite ceritinib reintroduction, lorlatinib was initiated. Treatment with the third-generation ALK inhibitor led to a deep and durable complete metabolic response, sustained for more than four years, including persistence of remission after treatment discontinuation, with minimal toxicity. This case highlights the potential role of sequential ALK inhibition to overcome acquired resistance in ALK-rearranged TC and underscores the importance of comprehensive molecular profiling to guide personalized treatment strategies in rare aggressive thyroid cancers.
ARISK STRATIFICATION AND LONG-TERM MONITORING IN PEDIATRIC THYROID CANCER: PREDICTIVE MARKERS FOR DISEASE PERSISTENCE.
Initial and dynamic risk stratification are crucial in managing pediatric differentiated thyroid carcinoma (DTC), aiming to guide treatment and long-term follow-up. While adult dynamic stratification is well established, pediatric data remain limited, and no formal recommendations exist for its use. To evaluate the prognostic value of early dynamic risk stratification (EDRS) and postoperative stimulated thyroglobulin (sPOTg) in predicting long-term outcomes in pediatric DTC and to compare EDRS with initial ATA pediatric risk stratification (IRS). We conducted a retrospective cohort study of 123 patients ≤18 years with DTC treated at a tertiary center. IRS and EDRS (1-3 years post-treatment) were compared to late dynamic response (LDRS, ≥10 years post-treatment). A total of 83 patients had complete long-term follow-up data. Associations were assessed using chi-square tests, logistic regression, Cohen's Kappa, and Cramér's V. ROC curve analysis evaluated the predictive value of sPOTg. Among 83 patients with ≥10 years of follow-up, EDRS showed a strong association with LDRS (Cramér's V = 0.829; p < 0.001), outperforming IRS (Cramér's V = 0.33; p = 0.0029). Concordance between EDRS and LDRS was substantial (Kappa = 0.79). Stimulated Postoperative Thyroglobulin (sPOTg) showed good discriminatory performance for disease persistence, with AUCs of 0.84 (95% CI: 0.70-0.95) at 1-3 years and 0.81 at ≥10 years. Early dynamic response is a strong predictor of long-term outcomes and may surpass IRS in prognostic accuracy. sPOTg is a valuable biomarker for both early and late risk assessment. Prospective multicenter validation is warranted.
Publicações recentes
Poorly differentiated thyroid carcinoma: a case report and literature review.
Hyperfunctioning distant metastases in high-grade differentiated thyroid carcinoma arising from HRAS-mutated follicular thyroid carcinoma: a case report and literature review.
📖 RevisãoImmunotherapy in Thyroid Cancer: Current Strategies and Challenges.
Predictors of Complete Remission in Differentiated Thyroid Cancer: A Study from the Nuclear Medicine Department of Ibn Rochd Hospital in Casablanca, Morocco.
A differentiated thyroid carcinoma-specific graded prognostic assessment for brain metastases: derivation in a 10,306-patient cohort and external validation.
📚 EuropePMC2.145 artigos no totalmostrando 199
Case Report: Lorlatinib for the treatment of ALK-rearranged poorly differentiated thyroid carcinoma after progression to prior ALK-specific tyrosine-kinase inhibitor.
Frontiers in oncologyARISK STRATIFICATION AND LONG-TERM MONITORING IN PEDIATRIC THYROID CANCER: PREDICTIVE MARKERS FOR DISEASE PERSISTENCE.
European thyroid journalEpidemiology, risk factor and prognostic factor of young differentiated thyroid carcinoma with distant metastasis: a retrospective cohort study.
American journal of cancer researchStatus of therapeutic nuclear medicine in Argentina.
Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)Sex-specific differences in patients with differentiated thyroid carcinoma and their possible impact on survival.
European journal of nuclear medicine and molecular imagingPrognostic significance of minimal extrathyroidal extension in differentiated thyroid carcinoma: a retrospective cohort study.
Brazilian journal of otorhinolaryngologySelective Use of Radioiodine Therapy in Differentiated Thyroid Carcinoma: A Population-Based Cohort Study.
Thyroid : official journal of the American Thyroid AssociationSimulation unlocked: transforming thyroid surgery training through high-fidelity and curriculum-based innovation-a systematic review.
Langenbeck's archives of surgeryThyroglobulin Autoantibodies Do Not Influence the Outcome of Patients With Differentiated Thyroid Carcinoma.
Endocrinology, diabetes & metabolismCYFRA 21-1 in lymph node fine-needle aspiration washouts: added value in differentiated thyroid cancer.
Clinical chemistry and laboratory medicineFgfr4 combined with inflammatory cytokines improves recurrence risk prediction in differentiated thyroid carcinoma: A retrospective cohort study.
Journal of medical biochemistry[Current status and controversies of thyroid stimulating hormone suppression therapy in low-risk differentiated thyroid carcinoma].
Zhonghua yi xue za zhiFibrosis-Driven Surgical Risk After Thyroid Nodule Ablation: Quantitative Clinicopathological Determinants of Complications in Post-Ablative Thyroidectomy-A Retrospective Cohort Study.
World journal of surgeryLenvatinib as Neoadjuvant Therapy in Locally Advanced Thyroid Cancer: CT-Based Selection and Outcomes From a 23-Patient Cohort.
Head & neckDifferences in laboratory reporting of thyroglobulin antibody positivity - a national survey across laboratories in the Netherlands.
Clinical chemistry and laboratory medicineSexual Function and Depressive Symptoms in Premenopausal Women with Differentiated Thyroid Cancer: A Cross-Sectional Study.
Thyroid : official journal of the American Thyroid AssociationVisualizing malignant progression: in situ CD109-based spatial immunofluorescence assay delineates papillary to anaplastic thyroid carcinoma transformation within the tumor microenvironment.
Scientific reportsEvaluation of three inflammation-associated blood indices for predicting malignancy in thyroid nodules.
Archives of endocrinology and metabolismThe molecular mechanisms and potential therapeutic implications of the crosstalk between DNA methylation and metabolic reprogramming in thyroid cancer.
Cell death discoveryTraining pathways and formal curricula in robotic bariatric surgery: a systematic review.
Journal of robotic surgeryPrognostic significance of preoperative thyroid hormone sensitivity status for recurrence in papillary thyroid carcinoma.
The oncologistPre-RAI Monocyte-to-Lymphocyte Ratio Predicts Early and Higher Recurrence Risk in Intermediate-Risk DTC, While PNI and NRI Show No Prognostic Value.
Clinical endocrinologyThe Role of 123I in the Management of Differentiated Thyroid Cancer: A Comprehensive Narrative Review.
Medical sciences (Basel, Switzerland)Comparable survival after lobectomy and total thyroidectomy for T3b differentiated thyroid carcinoma: A population-based study.
Oral oncologyComparative evaluation of dynamic risk stratification according to ATA 2015 and ATA 2025 in low-risk differentiated thyroid cancer without radioiodine ablation.
EndocrineCase Report: Management of a challenging case presenting with dysphagia after thyroidectomy requiring administration of liquid 131I via MIC-KEY low-profile tube-a multidisciplinary approach.
Frontiers in medicineOutside canonical BRAF p.V600E Box: 7 novel BRAF gene fusions in BRAF p.V600E WT papillary thyroid carcinoma.
Virchows Archiv : an international journal of pathologyClinical characteristics and risk analysis of lymph node metastasis in patients with cN0 differentiated thyroid carcinoma.
Scientific reportsConstruction and evaluation of a SPECT-based radiomics nomogram for predicting the therapeutic response to radioactive iodine in patients with differentiated thyroid carcinoma.
MedicineReconstruction of the chest wall after resection of a locally advanced poorly differentiated thyroid carcinoma with sternal infiltration: case report and literature review.
AME case reportsImplantation of cancer cells from transoral endoscopic thyroidectomy: a case report.
Gland surgerySynchronous Presence of Papillary, Medullary, and Anaplastic Thyroid Tumors in a Single Patient: A Rare Case Report.
The American journal of case reportsPrognostic Stratification of Highly Differentiated Thyroid Cancer Based on Molecular Genetic Studies.
Asian Pacific journal of cancer prevention : APJCPThyroid carcinoma follow-up: tertiary to primary care transition in Portugal.
Endocrine connectionsAnalysis of external dose rate attenuation and its related factors in differentiated thyroid carcinoma patients following I-131 therapy.
EJNMMI physicsMultidisciplinary team diagnosis and treatment of well-differentiated thyroid carcinoma: current landscape and future prospects.
The oncologistImmunotherapy response in microsatellite-stable poorly differentiated thyroid carcinoma with mismatch repair deficiency and high tumor mutational burden.
Archives of endocrinology and metabolismA Case of Thyroid Carcinoma Combined With Thyroid Hemiagenesis.
Case reports in endocrinology[Differentiated thyroid carcinoma in children and adolescents].
Problemy endokrinologiiEffects of High-dose Radioactive Iodine Therapy on Hormonal Profiles and Sperm Quality in Thyroidectomy Patients.
Molecular imaging and radionuclide therapyPatterns of radioiodine uptake combined with pulmonary nodule size in predicting long-term clinical outcomes of differentiated thyroid carcinoma patients with lung metastasis alone.
Asia Oceania journal of nuclear medicine & biologyA Randomized Trial Evaluating Intraoperative Ischemic Preconditioning of Parathyroid Glands During Total Thyroidectomy: A Signal for Earlier Parathyroid Function Recovery.
Journal of investigative surgery : the official journal of the Academy of Surgical ResearchTERT promoter mutations and recurrence patterns in differentiated thyroid carcinoma.
Endocrine-related cancerClinical comparative analysis of endoscopic thyroidectomy via the thoracoareolar approach versus open surgery for the treatment of differentiated thyroid cancer.
MedicineSomatostatin receptor expression for peptide receptor radionuclide therapy in Japanese patients with recurrent or metastatic differentiated thyroid cancer.
Annals of nuclear medicineMultiomics Profiling Reveals Distinct Immunosuppression and Metabolic Dysregulation in Aggressive Subtypes of Thyroid Cancer.
Molecular & cellular proteomics : MCPChallenging Subtypes and Mimics of Papillary Thyroid Carcinoma: Highlights from a 22nd International Congress of Cytology Slide Seminar (Case Reports).
Acta cytologicaEffects of Lenvatinib treatment for advanced differentiated thyroid cancer on cortisol deficiency.
Frontiers in endocrinologyHead-to-Head Comparison of [68Ga]Ga-DOTATATE PET/CT and [68Ga]Ga-NODAGA-LM3 PET/CT.
Journal of nuclear medicine : official publication, Society of Nuclear MedicineDefining the ATA-2025 'consider RAIT' zone in older patients with N1b PTC.
Endocrine-related cancerComplete resection of solitary pulmonary metastases in thyroid cancer: a case series report.
Journal of cardiothoracic surgeryLinoleic acid reduces sodium-iodide symporter by inhibiting endoplasmic reticulum stress in papillary thyroid carcinoma.
Journal of molecular endocrinologySolitary Flat Bone Metastasis of Follicular Thyroid Carcinoma: Complete Molecular and Partial Structural Response After 2 131I Therapies.
Journal of nuclear medicine technologyPersistent and Recurrent Differentiated Thyroid Cancer: A Surgical Perspective on Overdiagnosis.
The Journal of craniofacial surgeryThe influence of age-independent somatic driver alterations on clinical outcomes in paediatric and young adult thyroid cancer.
European thyroid journalMachine learning prediction of thyroid cancer recurrence for early screening and clinical decision pathways: a retrospective cohort study.
Discover oncologyPoorly differentiated thyroid carcinoma in identical twins: a report of two cases and review of the literature.
Thyroid researchSelected updates in thyroid, parathyroid, and adrenal gland pathology.
Human pathologyAn integrated single-cell and spatial transcriptomic atlas of thyroid cancer progression identifies prognostic fibroblast subpopulations.
JCI insightLevothyroxine dose prediction post-thyroidectomy for differentiated thyroid carcinoma.
Frontiers in endocrinologyUnderstanding the Factors That Influence Shared-Decision Making Around Surgical Resection of Low-Risk Thyroid Cancers: A Prospective Qualitative Study.
Thyroid : official journal of the American Thyroid AssociationAccuracy and Clinical Significance of Intraoperative Gross Extrathyroidal Extension (T3b) Assessment in Differentiated Thyroid Carcinoma.
CancersAssessment of levothyroxine therapy adequacy in low-risk differentiated thyroid carcinoma: a multicenter cohort study.
Frontiers in endocrinologyRevisiting Thyroglobulin Measurement: Current Methods and Future Perspectives Using Dried Blood Spot Sampling for Enhanced Clinical Practice.
MetabolitesSurgical Management of Poorly Differentiated Thyroid Carcinoma Extending Into the Superior Vena Cava: A Case Report.
Cureus[Treatment outcomes and prognostic analysis of 882 cases of poorly differentiated/anaplastic thyroid carcinoma in China: a multicenter study].
Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgeryBrain Metastases From Differentiated Thyroid Cancer in the Era of Targeted Therapies: A Multi-Center Retrospective Cohort.
Head & neckLevothyroxine suppression therapy improves maternal and neonatal outcomes in pregnancy after thyroidectomy for differentiated thyroid carcinoma.
American journal of translational researchThyroid-Stimulating Hormone Suppression Therapy in Thyroid Cancer: Balancing Benefits and Harms.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical EndocrinologistsPrognostic factors evaluated in differentiated thyroid carcinomas.
Endocrine connectionsPredictive value of serum thyroglobulin after surgery and prior to I-131 therapy in patients with differentiated thyroid carcinoma, examined at two different time intervals.
Caspian journal of internal medicineMultimodal spectrum of approach in poorly differentiated thyroid carcinoma (an updated analysis).
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieDiagnostic Challenges, Prognostic Assessment, and Treatment Strategies in High-Grade Differentiated Thyroid Carcinoma.
Endocrinology and metabolism (Seoul, Korea)Integrating Robotic Bilateral Axillo-Breast Approach Thyroidectomy with Molecular Diagnostics and Artificial Intelligence in Thyroid Cancer Care.
Biomolecules & therapeuticsTransoral endoscopic thyroidectomy using the vestibular approach in pediatric patients: 5-year experience in a single center in Vietnam.
World journal of pediatric surgeryComparison of surgical trauma between three endoscopic thyroidectomy approaches and open surgery.
Frontiers in oncologyPrognostic Factors Affecting Iodine-131 Treatment Efficacy in Patients With Differentiated Thyroid Carcinoma: A Risk-Stratified Analysis.
Nutrition and cancerType 2 Deiodinase in Cancer-Associated Fibroblasts is Required to Sustain Growth of Poorly and Undifferentiated Thyroid Cancer.
Thyroid : official journal of the American Thyroid AssociationAge-dependent effects of surgical approach in T3b differentiated thyroid carcinoma: a population-based analysis using machine learning.
Endocrine-related cancerLong-Term Disease Control With Lenvatinib in Metastatic Malignant Struma Ovarii: A Case Report.
CureusExtensive Intravenous Tumor Thrombus and Right Atrial Bland Thrombus From Poorly Differentiated Thyroid Cancer: 18 F-FDG PET/CT Imaging Findings.
Clinical nuclear medicineEmerging frontiers in SERS-integrated optical waveguides: advancing portable and ultra-sensitive detection for trace liquid analysis.
Light, science & applicationsPost-thyroidectomy ultrasonography versus thyroglobulin as a surveillance tool for locoregional recurrence in patients with differentiated thyroid carcinoma: A single centre 10-year study.
Frontiers in endocrinologyInternational Consensus on the Requirements for Definitions of Complete Remission and Recurrence of Differentiated Thyroid Cancer: a Delphi Study (ICON-DTC).
European journal of endocrinologyParity as a Risk Factor for Differentiated Thyroid Carcinoma- A Population-Based Study.
The Journal of clinical endocrinology and metabolismRare Presentation of Mandibular Metastases from Differentiated Thyroid Carcinoma: A Case Series - Experience from a Single Tertiary Care Hospital.
Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, IndiaA Randomized Controlled Trial to Evaluate the Effects of Topical Intraoperative Corticosteroid Application on Voice Quality in Thyroid Surgery With Preserved Recurrent Laryngeal Nerves.
World journal of surgeryPost-therapy I-131 whole-body scan with SPECT/computed tomography-based mapping of residual metastatic lymph nodes in differentiated thyroid cancer.
Nuclear medicine communicationsGut microbiota and metabolite profiles in thyroid cancer lymph node metastasis: a multi-omics analysis.
Scientific reportsNovel carbon paper-based solid-state nanochannels integrated with click chemistry for sensitive detection of thyroid stimulating hormone.
Biosensors & bioelectronicsPrognostic analysis of persistent disease in medium-to high-risk children and adolescents with differentiated thyroid carcinoma.
Journal of pediatric endocrinology & metabolism : JPEMMultimodal ultrasound to predict central cervical lymph node metastasis in clinically lymph node-negative differentiated thyroid carcinomas: a two-center retrospective study.
Gland surgeryUnusual Soft Tissue and Muscle Metastases in Papillary Thyroid Carcinoma: Insights from 131I Scintigraphy and 18F-FDG PET/CT.
Molecular imaging and radionuclide therapyCore Outcome Set of the Surgical Treatment of Differentiated Thyroid Carcinoma: International Consensus by Delphi Study.
Thyroid : official journal of the American Thyroid AssociationIn medio stat virtus: towards an evidence rather than dogma based discussion on indicating post-operative I-131 therapy for differentiated thyroid carcinoma.
European journal of nuclear medicine and molecular imagingTowards harmonised paediatric thyroid cancer care: adult comparisons and gaps.
Endocrine-related cancerSurgical Outcomes Following Neoadjuvant-Targeted Therapy for Advanced Differentiated Thyroid Cancer-Real-World Data.
Clinical endocrinologyDynamic risk stratification in patients with follicular thyroid carcinoma treated with lobectomy.
European thyroid journalPrognosis of differentiated thyroid cancer in patients with Graves' disease: a meta-analysis.
Thyroid researchA rare case of isolated metastatic disease in a young woman with papillary thyroid carcinoma and a novel method for diagnosis: illustrative case.
Journal of neurosurgery. Case lessonsSomatic genetic alterations in the development and progression in thyroid tumors of follicular cells.
European thyroid journalPatterns of Lateral Lymph Node Involvement by Neck Level in cNIb Differentiated Thyroid Carcinoma: A Systematic Review and Meta-Analysis.
Diagnostics (Basel, Switzerland)Learning curve and functional safety in robotic thyroidectomy via bilateral axillo-breast approach: a prospective study of 537 cases.
Surgical endoscopyA rare case of follicular thyroid carcinoma with unknown primary tumor location.
Nuclear medicine review. Central & Eastern EuropeDefining the role of thyroidectomy in patients with metastatic differentiated thyroid carcinoma by age groups.
American journal of surgeryHigh Prevalence of Potential Molecular Therapeutic Targets in Poorly Differentiated Thyroid Carcinoma.
Endocrine pathologyExpanding the Phenotypic Spectrum of Differentiated High-Grade Thyroid Carcinoma: An Extracranial Mass as the First Presentation.
Case reports in endocrinologyMetastatic follicular thyroid carcinoma to the brain during pregnancy: A neurosurgical and ethical challenge.
Surgical neurology internationalCase of cutaneous metastasis from presumed poorly differentiated thyroid carcinoma: a case report.
Journal of medical case reportsIn-vitro Assessment of the Proliferation and Apoptosis of Thyroid Cancer Cells Using Valproic Acid and Retinoic Acid Alone and in Combination with Etoposide and Epirubicin.
Iranian journal of pharmaceutical research : IJPRPrognostic Value of Hematological Inflammatory Indices (PLR, NLR, SII) in Medium and High-Risk Papillary Thyroid Carcinoma: A Multicenter Cohort Study.
Clinical endocrinologyHomologous Recombination in Thyroid Tumor Samples.
International journal of molecular sciencesMolecular Diagnostics and Personalized Therapeutics in Differentiated Thyroid Carcinoma: A Clinically Oriented Review.
Diagnostics (Basel, Switzerland)Radioactive iodine and male reproductive health in thyroid cancer survivors: evidence of delayed gonadal dysfunction.
Journal of endocrinological investigationImmunophenotypic Panel for Comprehensive Characterization of Aggressive Thyroid Carcinomas.
CellsMalignant Potential of Thyroid Follicular Nodular Disease With Solid/Trabecular Components: A Case Report.
Pathology internationalLenvatinib-Induced Glomerular Microangiopathy in a Patient With Poorly Differentiated Thyroid Carcinoma: A Long-Term Renal Function Change With Biopsy Findings.
CureusClinical value of 99mTc-MIBI scintigraphy combined with posttherapeutic 131I whole-body scanning in patients with differentiated thyroid cancer with sTg ≥10 ng/mL before initial radioiodine therapy: a retrospective study.
Quantitative imaging in medicine and surgeryPrimary squamous thyroid cancer: A case report.
Oncology lettersRadioactive iodine for differentiated thyroid carcinoma.
Current opinion in endocrinology, diabetes, and obesityUltrasound-Guided Optimization of Preoperative Chemoradiotherapy Using ¹³¹I SPECT/CT for Enhanced Targeting in Differentiated Thyroid Carcinoma.
Cancer biotherapy & radiopharmaceuticalsA previously unreported triad of poorly differentiated thyroid carcinoma, parathyroid adenoma, and paraganglioma: random coincidence or hidden genetic etiology-a case report.
Journal of medical case reportsImplementation of a comprehensive medication management service for radioiodine therapy patients at an oncology hospital in Rio de Janeiro.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy PractitionersEnvironmental and lifestyle factors and risk of thyroid carcinoma: a cross-sectional study.
EndocrineClinical and Prognostic Features of Malignant Thyroid Nodules With Atypia of Undetermined Significance Cytology: Evaluation of Nuclear Atypia-Based Subgroups.
Diagnostic cytopathologyLipidomic Profiling: A Promising New Direction in the Diagnosis and Management of Thyroid Cancer?
CureusTumor response and thyroglobulin change in differentiated thyroid carcinoma treated with dabrafenib plus trametinib.
Cancer chemotherapy and pharmacologyPeptide Receptor Radionuclide Therapy with Lu-177-DOTATATE and Monitoring with Somatostatin Receptor PET/CT in Patients with Advanced Differentiated Thyroid Carcinoma.
Molecular imaging and biologyRisk Stratification of Thyroid Nodules 10 mm in Diameter or Less: Strength and Pitfalls of the Ultrasonographic Assessment From a Cross-Sectional Study.
International journal of endocrinologyThe Role of External Beam Radiation Therapy in Thyroid Cancer Management: A Scoping Review.
International journal of radiation oncology, biology, physics[Female reproductive function -after radioiodine therapy for differentiated thyroid carcinoma].
Problemy endokrinologiiTheranostics in nuclear medicine: the era of precision oncology.
Medical oncology (Northwood, London, England)Thyroid Hormone Withdrawal Yields Higher 131I Absorbed Dose to Metastases Than rhTSH Stimulation in Differentiated Thyroid Cancer: Evidence from a Large 124I PET/CT Dosimetry Cohort.
Journal of nuclear medicine : official publication, Society of Nuclear MedicineA machine learning model for predicting bone and/or lung metastasis in differentiated thyroid carcinoma: enhancing precision in risk stratification.
Frontiers in endocrinologyImpact of Scar on Quality of Life in Well-Differentiated Thyroid Carcinoma: A Systematic Review.
OTO openDiagnosing Thyroid Lesions Through A Morphology-Molecular Lens: Four Case-Based Lessons From 22nd International Congress of Cytology-Florence 2025.
Diagnostic cytopathologyDifferential expression profiles of immunoregulatory genes in anaplastic thyroid carcinomas with a coexistent papillary carcinoma component.
Virchows Archiv : an international journal of pathologyThe association between composite inflammatory indicators and the clinicopathological characteristics of differentiated thyroid carcinoma.
Frontiers in molecular biosciencesEffect of Thyroid-Stimulating Hormone Suppression on Bone Mineral Density in Patients with Differentiated Thyroid Carcinoma: A Single Center Retrospective Study.
Journal of bone metabolismPrognostic Factors in Thyroid Cancer Patients With Brain Metastases: A Systematic Review and Meta-Analysis.
Thyroid : official journal of the American Thyroid AssociationFeasibility of Doing a Safe Robotic Thyroidectomy in a Developing Country and Comparison of 2 Different Techniques.
Indian journal of surgical oncologyMarital status, race/ethnicity, and outcomes in well-differentiated thyroid cancer in the elderly.
Gland surgeryProlonged response to lenvatinib in a poorly differentiated thyroid carcinoma with leptomeningeal carcinomatosis.
Annales d'endocrinologie18F-prostate-specific membrane antigen-1007 positron emission tomography / computed tomography detects occult leptomeningeal metastases in poorly differentiated thyroid carcinoma misdiagnosed as vascular mimicry on magnetic resonance imaging.
Polish archives of internal medicineCardiovascular risk after total thyroidectomy in patients with differentiated thyroid carcinoma undergoing levothyroxine replacement monotherapy.
Frontiers in endocrinologyHigh risk factors, molecular features and clinical management for radioactive iodine-refractory differentiated thyroid carcinoma.
Frontiers in oncologyComparative analysis of three thyroglobulin immunoassays: analytical performance and clinical implications.
Thyroid researchDiagnostic value of thyroid-related serological indicators and pan-immune-inflammation value for differentiated thyroid carcinoma.
Frontiers in immunologySpatial Transcriptomics Reveals Transcriptomic and Immune Microenvironment Reprogramming during Thyroid Carcinoma Dedifferentiation.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)Impact of tumor size on oncological and surgical outcomes in robot-assisted transaxillary surgery for papillary thyroid carcinoma.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical OncologyDiagnostic Evaluation of Anaplastic Thyroid Carcinoma in Core Biopsy Specimens: Morphologic, Immunohistochemical, Molecular, and Therapeutic Considerations.
Endocrine pathologyDevelopment of a new TNM staging system for poorly differentiated thyroid carcinoma: a multicenter cohort study.
Frontiers in endocrinologyMultifocal papillary thyroid microcarcinomas: is the total tumor diameter associated with the tumor behavior? A retrospective cohort study.
Einstein (Sao Paulo, Brazil)Optimizing Thyroglobulin Interpretation to Reduce Ultrasound Examinations in the Follow-Up of Differentiated Thyroid Carcinoma.
Clinical endocrinologyPreoperative serum lipids as novel predictors for concomitant thyroid carcinoma in Graves' disease.
PeerJMachine Learning Prediction of Recurrence in Pediatric Thyroid Cancer: Malignant Endocrine Tumors Cohort Analysis Using XGBoost and SHAP.
The Journal of clinical endocrinology and metabolismProgression of Follicular Thyroid Carcinomas to Anaplastic Thyroid Carcinomas: Molecular and Clinicopathologic Characteristics with Comparison to Papillary Thyroid Carcinoma-Derived Anaplastic Thyroid Carcinomas.
Endocrine pathologyRisk factors and outcomes of metastatic poorly differentiated thyroid carcinoma.
World journal of clinical casesEfficacy of Lenvatinib Therapy for Thyroid Cancer by Pathological Type: A Retrospective Real-world Study.
In vivo (Athens, Greece)Development and validation of a nomogram to predict failure of initial radioactive iodine therapy in differentiated thyroid cancer: a retrospective cohort study.
Scientific reportsIdentifying risk factors associated with refractoriness to radioiodine therapy in differentiated thyroid cancer.
Archives of endocrinology and metabolismThe approaches and challenges in the management of differentiated thyroid carcinoma.
Current opinion in endocrinology, diabetes, and obesitySynchronous Presentation of Type 2 Marine-Lenhart Syndrome and Differentiated Thyroid Carcinoma Manifesting as Thyroid Storm.
Case reports in endocrinologyHydrogel-driven innovations for targeted delivery, immune modulation, and tissue repair in thyroid cancer therapy.
Frontiers in cell and developmental biologyPostoperative nomogram for predicting involved lymph node in differentiated thyroid carcinoma: an observational study.
Future oncology (London, England)Evaluation of common genetic risk factors for differentiated thyroid cancer in the Thai population.
Biomedical reportsEnhancing Recurrent Laryngeal Nerve Detection with Neural Autofluorescence in Thyroid Surgery.
Journal of the American College of SurgeonsAssociation between types of surgery and cancer-specific death in patients with early differentiated thyroid carcinoma: a real-world study.
Frontiers in oncologyClinical and Pathological Factors Associated with Disease Persistence in Pediatric Patients with Differentiated Thyroid Carcinoma.
Thyroid : official journal of the American Thyroid AssociationRisk-adapted therapy in pediatric thyroid cancer: initial experience from a national reference program by the MET group.
European thyroid journalA Rare Concurrence of Anaplastic and Papillary Thyroid Carcinomas: A Case Report and Literature Review.
Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of IndiaThe Evolving Role of Radioactive Iodine in Thyroid Cancer Diagnosis and Treatment.
Endocrinology and metabolism clinics of North AmericaNavigating the complexity of current interventional radiological approaches for distant metastases in thyroid cancer.
Frontiers in endocrinologyManagement of Hypoparathyroidism After Total Thyroidectomy for Differentiated Thyroid Cancer in Children and Young Adolescents: Experiences From a Multicenter Cohort in China.
Journal of pediatric surgeryThe Role of FNA-CYFRA 21-1 in Cervical Lymph Node Metastasis of Differentiated Thyroid Cancer.
The LaryngoscopeInsulin resistance factors associated with differentiated thyroid carcinoma and malignant cytology: serum thyroxine as an associated factor.
Annals of medicineRisk factors associated with postoperative complications in pediatric thyroidectomy: A single-center Vietnamese experience.
International journal of pediatric otorhinolaryngologySurvival benefits of primary tumor resection in metastatic differentiated thyroid cancer: an analysis of SEER data.
Scientific reportsComparison of the surgical outcomes of endoscopic thyroidectomy via a contralateral-axillo-bilateral-breast approach and open thyroidectomy.
Langenbeck's archives of surgeryBrain metastasis from differentiated thyroid carcinoma responding to radioiodine therapy.
Asia Oceania journal of nuclear medicine & biologyPrednisone-aided gross thyroid remnant ablation using 5.55 GBq of radioiodine in patients with differentiated thyroid cancer.
Nuclear medicine communicationsAutoimmune thyroiditis in paediatric thyroid cancer: clinical features and outcomes.
European journal of endocrinologyMulticenter analysis of radioactive iodine therapy outcomes after total thyroidectomy for T1-T2 stage papillary thyroid carcinoma with cervical lymph node metastasis in China.
International journal of surgery (London, England)Impact of the 2015 American Thyroid Association Guidelines on Treatment of Low-Risk Thyroid Cancer.
Laryngoscope investigative otolaryngologyDistinctive hobnail subtype of papillary thyroid carcinoma: a case series and short review of literature.
Hormones (Athens, Greece)Thyroid-stimulating immunoglobulin is not associated with aggressive clinicopathologic features in concomitant Graves' disease and papillary thyroid cancer.
American journal of surgeryNOVEL INSIGHTS IN ADVANCED THYROID CARCINOMA: FROM MECHANISMS TO TREATMENTS: Development of 3D organoid models to study aggressive thyroid cancers.
European thyroid journalCirculating Citrate is Elevated During Profound Hypothyroidism: An Observational Study.
Metabolic syndrome and related disordersSystemic Therapeutic Options in Radioiodine-Refractory Differentiated Thyroid Cancer: Current Indications and Optimal Timing.
CancersFeasibility of Short-Term Redifferentiation in Patients with Radioactive Iodine-Refractory Metastatic Thyroid Cancer.
Journal of nuclear medicine : official publication, Society of Nuclear MedicineMeasurement of Effective Half-life of Iodine-131 to Optimize Safety Release Instructions after Treatment for Patients with Differentiated Thyroid Cancer.
Health physicsFocal High-Grade Areas with a Tumor-in-Tumor Pattern: Another Feature of Pediatric DICER1-Associated Thyroid Carcinoma?
Endocrine pathologyIntegrated microbiome and metabolome analysis reveals a novel interplay between gut microbiota and metabolites in differentiated thyroid carcinoma.
BMC microbiologyExpanding the histologic spectrum of thyroid neoplasms with NTRK1/2/3 or ALK translocation: a single-center retrospective study of 82 cases.
Virchows Archiv : an international journal of pathologyWhy so many doses, and why now?
European thyroid journalAdjuvant External Beam Radiotherapy Reduces Local Recurrence in Poorly Differentiated Thyroid Cancer : A Multicenter Retrospective Cohort Study Describing Outcomes in the Treatment of Resectable Poorly Differentiated Thyroid Cancer.
Annals of surgical oncologyEffectiveness of radioiodine therapy on preventing recurrence in differentiated thyroid carcinoma: a systematic review.
Journal of the Egyptian National Cancer InstituteChallenging diagnosis and treatment of rare paranasal sinus metastasis from thyroid cancer: a case report and literature review.
Frontiers in endocrinologyHypoxia Inhibitor Improves Iodine Uptake Disorder in Thyroid Cancer Through the hsa_circ_0023990/miR-448/DNMT1/NIS Axis.
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- The molecular mechanisms and potential therapeutic implications of the crosstalk between DNA methylation and metabolic reprogramming in thyroid cancer.
- The Role of 123I in the Management of Differentiated Thyroid Cancer: A Comprehensive Narrative Review.
- Multiomics Profiling Reveals Distinct Immunosuppression and Metabolic Dysregulation in Aggressive Subtypes of Thyroid Cancer.
- Case Report: Lorlatinib for the treatment of ALK-rearranged poorly differentiated thyroid carcinoma after progression to prior ALK-specific tyrosine-kinase inhibitor.
- ARISK STRATIFICATION AND LONG-TERM MONITORING IN PEDIATRIC THYROID CANCER: PREDICTIVE MARKERS FOR DISEASE PERSISTENCE.
- Poorly differentiated thyroid carcinoma: a case report and literature review.
- Hyperfunctioning distant metastases in high-grade differentiated thyroid carcinoma arising from HRAS-mutated follicular thyroid carcinoma: a case report and literature review.
- Immunotherapy in Thyroid Cancer: Current Strategies and Challenges.
- Predictors of Complete Remission in Differentiated Thyroid Cancer: A Study from the Nuclear Medicine Department of Ibn Rochd Hospital in Casablanca, Morocco.
- A differentiated thyroid carcinoma-specific graded prognostic assessment for brain metastases: derivation in a 10,306-patient cohort and external validation.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:146(Orphanet)
- MONDO:0015447(MONDO)
- GARD:12027(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Q56013722(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
