Miopatia e diabetes mellitus

North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)

NCT01694940

KHENERFIN Study: A Trial to Evaluate the Efficacy and Safety of Sonlicromanol in Primary Mitochondrial Diseases

NCT06451757

Study of N-acetylcysteine in the Treatment of Patients With the m.3243A>G Mutation and Low Brain Glutathione Levels

NCT05241262

Development of Non-Invasive Prenatal Diagnosis for Single Gene Disorders

NCT06147414

OMT-28 in Patients With Primary Mitochondrial Disease (PMD) (PMD-OPTION)

NCT05972954

CONCLUÍDO

🟢 Recrutando agora

4 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

NCT01694940 · North American Mitochondrial Disease Consortium Patient Regi…Recrutando

NCT06451757 · KHENERFIN Study: A Trial to Evaluate the Efficacy and Safety…Recrutando

PHASE3

NCT05241262 · Study of N-acetylcysteine in the Treatment of Patients With …Recrutando

PHASE1

NCT06147414 · Development of Non-Invasive Prenatal Diagnosis for Single Ge…Recrutando

Outros ensaios clínicos

0 ensaios clínicos encontrados.

Distribuição por fase

NCT05972954 · OMT-28 in Patients With Primary Mitochondrial Disease (PMD) …Concluído

PHASE2

Ver todos no ClinicalTrials.gov

🧪 Está conduzindo uma pesquisa?

Divulgue para pacientes e familiares que acompanham esta doença.

Divulgar pesquisa →

Publicações mais relevantes

🥇Melhor nível de evidência: Revisão sistemática

Timeline de publicações

0 papers (10 anos)

#1

Heterogeneous phenotype and cardiovascular comorbidities in Swedish patients with spinobulbar muscular atrophy.

Journal of neurology2026 Jan 10

Spinobulbar muscular atrophy (SBMA) is an X-linked neuromuscular disorder characterized by adult-onset progressive muscle atrophy, flaccid paresis, and bulbar palsy. In addition, increasing evidence indicates that SBMA is a multisystem disorder with prominent non-motor symptoms, such as sensory neuropathy, androgen insensitivity, and glucose intolerance. This study aimed to further characterize the clinical manifestations and biomarker profile in a large Swedish SBMA cohort. 49 genetically confirmed SBMA patients were identified from a motor neuron disease database at Umeå University Hospital, Sweden. CAG repeat length in the androgen receptor (AR) gene was assessed by RP-PCR. Blood samples were analyzed for cardiovascular and muscle biomarkers. Clinical data were collected from medical records and interviews, with autopsy findings reviewed in two cases. The mean CAG repeat length was 43.1, with a mean age at motor symptom onset of 58.6 years. Notably, 19% of patients initially presented with sensory symptoms. High prevalence of hypertonia (70%), diabetes mellitus (39%), and cardiac disease (38%) was observed. Elevated troponin levels were common, and pNfL (neurofilament light chain in plasma) was elevated in seven patients, likely reflecting combined cerebrovascular and cardiovascular comorbidity. Importantly, two of these seven patients exhibited rapid disease progression, and a concomitant diagnosis of ALS was confirmed histopathologically. This cohort was characterized by a relatively low number of AR gene CAG repeats and a late onset of motor symptoms. Sensory symptoms frequently occurred before motor decline. Cardiovascular disease and diabetes were common comorbidities and, in some cases, preceded neurological symptoms. These findings underscore the need for improved clinical awareness of the heterogeneous presentation of SBMA and support routine cardiovascular monitoring to reduce diagnostic delays and prevent early mortality.

#2

Effectiveness and Safety of Statins in Type 2 Diabetes According to Baseline Cardiovascular Risk : A Target Trial Emulation Study.

Annals of internal medicine2026 Feb

Whether statins benefit patients with type 2 diabetes mellitus (T2DM) with low predicted 10-year cardiovascular risk is uncertain. To evaluate the effectiveness and safety of statin initiation for primary prevention among adults with T2DM stratified by predicted 10-year risk for cardiovascular disease (CVD). Cohort study using target trial emulation. U.K. primary care using the IQVIA Medical Research Data database. Persons aged 25 to 84 years with a diagnosis of T2DM between 2005 and 2016 and no history of coronary artery disease, myocardial infarction, stroke, heart failure, myopathy, liver disease, rheumatic heart disease, schizophrenia, or cancer. Statin initiation versus noninitiation, with estimation of the observational analogues of the intention-to-treat effect. Statin initiators were propensity score-matched to noninitiators in a 1:4 ratio within 4 QRISK3 strata of 10-year predicted cardiovascular risk: low (<10%), intermediate (10% to 19%), high (20% to 29%), and very high (≥30%). Absolute risk differences (RDs) and risk ratios (RRs) at 10 years of follow-up for all-cause mortality and major CVD, as well as myopathy and liver dysfunction. Statin initiation was associated with reductions in all-cause mortality and major CVD across QRISK3 strata. In the low-risk stratum, RDs and RRs were -0.53% (95% CI, -0.90% to -0.08%) and 0.80 (95% CI, 0.67 to 0.97), respectively, for all-cause mortality and -0.83% (95% CI, -1.28% to -0.34%) and 0.78 (95% CI, 0.66 to 0.91), respectively, for major CVD. A small increased risk for myopathy was observed in the moderate-risk stratum only, and there was no associated increased risk for liver dysfunction in any stratum. Unmeasured confounding and underascertainment of some hospitalization outcomes. Statin use in T2DM for primary prevention was associated with reductions in all-cause mortality and major CVD across the full spectrum of predicted cardiovascular risk. National Natural Science Foundation of China.

#3

Role of LPC 18:1 in the Lipid Metabolic Response to Combined Vitamin D and Resistance Exercise for Protecting Diabetic Skeletal Muscle Function.

Medicine and science in sports and exercise2026 Jan 01

We have previously found that vitamin D and resistance exercise synergistically improve type 2 diabetes mellitus (T2DM)-related skeletal muscle atrophy. This study aims to investigate the effect of varying exercise intensity on synergistic effects of vitamin D and resistance exercise on their efficacy in improving T2DM-induced myopathy and to further elucidate the underlying mechanism. We compared the effects of vitamin D combined with low-, moderate-, and high-intensity resistance exercise on metabolic status and skeletal muscle function. Then, we explored the mechanism through lipidomic analysis in diabetic rats and verified in adults with T2DM. We found that combined intervention of vitamin D and medium-resistivity volume (MRV) exercise most effectively improved glucose metabolism and insulin sensitivity and increased muscular mass and strength, resulting to alleviated gastrocnemius muscle atrophy in diabetic rats. Vitamin D combined with MRV intervention increased expressions of vitamin D receptor, whereas lysophosphatidylcholine acyltransferase 3, activated p38 MAPK, and ERK1/2 signaling pathways suppressed inflammatory responses. Moreover, lipidomic analysis of gastrocnemius muscle indicated that lysophosphatidylcholine (LPC) 18:1 exhibited the most significant restoration after intervention. Notably, in adults with T2DM, reduced changes in plasma LPC 18:1 levels exhibited positive correlations with decreased appendicular skeletal muscle index, upper limb muscle mass, and thigh muscle mass. Our findings suggested that vitamin D combined with MRV intervention has more pronounced effect on improving T2DM-related skeletal muscle atrophy. Additionally, LPC 18:1 may be a key target for regulating skeletal muscle function through p38 MAPK/ERK and inflammatory signaling pathways. These results provide novel insights for the prevention and treatment of T2DM-related skeletal muscle atrophy through lifestyle modifications.

#4

Effects of Diactive-1-Supported Progressive Resistance Training on Body Composition in Youth With Type 1 Diabetes.

Journal of cachexia, sarcopenia and muscle2026 Apr

Compared to their healthy peers, children and adolescents with type 1 diabetes are at an increased risk of adverse changes in body composition, including increased fat mass along with reductions in lean and bone mass. Although exercise has shown promise in improving body mass index in this population, the individual effects of resistance training on specific body composition parameters remain understudied. The aim of the study was to evaluate the effects of resistance training supported by the mHealth application Diactive-1 on body composition in children and adolescents with type 1 diabetes. Sixty-two participants with type 1 diabetes (aged 8-18 years old; 48% females) participated in a 24-week randomised controlled trial and were assigned to either the usual care group (n = 32) or the exercise group (n = 30). The intervention was delivered via the Diactive-1 app, which generates progressive overload resistance training programmes tailored to real-time glycaemia and provides educational support. Body composition was assessed using anthropometry and dual-energy X-ray absorptiometry, with fat, lean and bone measurements standardised by age, sex and ethnicity. Linear mixed models were used to evaluate between-group differences in change over time under both intention-to-treat (ITT) and per-protocol (PP) approaches. At 24 weeks, in the ITT analysis, the intervention group showed greater gains in lean mass (mean difference [MD] = 0.88 kg; 95% confidence interval [CI] 0.09 to 1.66; Hedges' g = 0.568) and whole-body bone mineral content less head (MD = 32.40 g; 95% CI 6.90 to 57.89; g = 0.644) compared with those in the usual care group. No changes were observed in anthropometric measures, fat mass-related regions or standardised variables (p > 0.05). The risk of probable sarcopenia was lower in the intervention group (relative risk [RR] = 0.17; 95% CI 0.04 to 0.73; Cohen's h = 0.987) than in the usual care group. Findings were directionally consistent in the PP analysis. This intervention increased bone-related outcomes and was associated with modest gains in lean mass and a lower risk of probable sarcopenia in youths with type 1 diabetes. These findings highlight the potential of the Diactive-1 app as an adjunct tool to support musculoskeletal health in youths with type 1 diabetes. ClinicalTrials.gov identifier: NCT06048757.

#5

HMGB1: a key molecule linking chronic inflammation to complications in type 2 diabetes mellitus and a target for exercise intervention.

Frontiers in endocrinology2026

The pathological process of type 2 diabetes mellitus (T2DM) is closely associated with chronic low-grade inflammation. High mobility group box 1 (HMGB1), a key damage-associated molecular pattern (DAMP), is frequently dysregulated in T2DM and is implicated in promoting insulin resistance (IR), β cell dysfunction, and the progression of multiple complications-including cardiovascular disease, nephropathy, cognitive impairment, myopathy, and dyslipidemia-primarily through activating signaling pathways such as RAGE/TLR4-NF-κB. Exercise, a cornerstone non-pharmacological intervention, effectively mitigates HMGB1-driven pathology through multifaceted mechanisms. These include direct downregulation of HMGB1 expression and suppression of its downstream inflammatory pathways, as well as indirect effects via improved glycemic control, enhancing autophagy, and reduced oxidative stress. This review aims to systematically examine the evidence for the role of HMGB1 in T2DM pathogenesis and its complications, and to evaluate exercise as a potential strategy to target this inflammatory pathway, thereby providing a theoretical framework for future therapeutic approaches.

Publicações recentes

Psychosocial implications of rare genetic skin diseases affecting appearance on daily life experiences, emotional state, self-perception and quality of life in adults: a systematic review.

🥇 Revisão sistemática

Orphanet J Rare Dis2023 Feb 23

Ver todas no PubMed

📚 EuropePMC3 artigos no totalmostrando 199

Journal of cachexia, sarcopenia and muscle

Effects of Diactive-1-Supported Progressive Resistance Training on Body Composition in Youth With Type 1 Diabetes.

HMGB1: a key molecule linking chronic inflammation to complications in type 2 diabetes mellitus and a target for exercise intervention.

Journal of the American Geriatrics Society

Statin Therapy for Primary Prevention and Clinical Outcomes in Adults Aged 80 and Older: A Retrospective Comparative Cohort Study.

Endoplasmic reticulum stress in skeletal muscle dysfunction of type 2 diabetes: mechanisms and therapeutic implications.

International immunopharmacology

A severe case of rhabdomyolysis, acute kidney injury, cardiogenic shock, and chronic complications caused by an excessively large dose of Tripterygium glycoside.

Diseases (Basel, Switzerland)

Left Atrial Strain as a Marker of Supraventricular Arrhythmia Risk in Type 2 Diabetes Mellitus.

Journal of the National Medical Association

Erythematous rash and proximal muscle weakness in a 59-year-old woman: Delayed diagnosis of dermatomyositis in a patient with skin of color.

British journal of sports medicine

Clinical importance of simple muscular fitness tests to predict long-term health conditions: a systematic review and meta-analysis of 94 cohort studies.

Efficacy and side effect of transcatheter arterial embolization using a novel embolic agent for lateral epicondylitis in a diabetic patient: A case report.

Medicine

Endocrine, metabolic & immune disorders drug targets

Mitochondrial Myopathy, Lactic Acidosis, and Stroke-Like Episodes Combined with Diabetes: A Case Report.

Rheumatology (Oxford, England)

Exploring the effects of GLP-1 receptor agonists in fibromyalgia: a propensity-matched real-world cohort using the TriNetX research platform.

Heterogeneous phenotype and cardiovascular comorbidities in Swedish patients with spinobulbar muscular atrophy.

Journal of neurology

Sodium-Glucose Cotransporter 2 Inhibitors and Reduced Fibromyalgia Risk in Patients With Diabetes: A Target Trial Emulation Study.

In vivo (Athens, Greece)

Arthritis & rheumatology (Hoboken, N.J.)

Glucagon-Like Peptide 1 Receptor Agonists, Sodium-Glucose Cotransporter 2 Inhibitors, and Risk of Autoimmune Rheumatic Diseases.

Annals of internal medicine

Effectiveness and Safety of Statins in Type 2 Diabetes According to Baseline Cardiovascular Risk : A Target Trial Emulation Study.

Journal of orthopaedic surgery and research

The HMGB1/RAGE/β-catenin axis mediates aberrant osteogenic-tenogenic differentiation imbalance of tendon stem/progenitor cells in diabetic tendinopathy.

Insulin Deficiency Exacerbates Muscle Atrophy and Osteopenia in Chrebp Knockout Mice.

Biochimica et biophysica acta. Molecular basis of disease

Swimming exercise attenuates diabetic myopathy and is associated with histological and mitochondrial changes in pregnant rats (Rattus norvegicus).

Phytomedicine : international journal of phytotherapy and phytopharmacology

Anemarrhena asphodeloides-derived small extracellular vesicle ameliorate diabetes-induced muscle atrophy via activating Pink1-mediated mitophagy.

Endocrine Comorbidities in Fibromyalgia.

Clinical endocrinology

Annals of clinical and translational neurology

Reduced Muscular Carnosine in Proximal Myotonic Myopathy-A Pilot 1H-MRS Study.

Human reproduction (Oxford, England)

Male infertility and risk of cardiometabolic conditions: a population-based cohort study.

Journal of geriatric physical therapy (2001)

Negative Impact of Diabetic Polyneuropathy on Muscle Weakness in the Lower Extremities of Older Patients Undergoing Coronary Artery Bypass Graft Surgery: A Retrospective Cohort Study.

Rheumatology (Oxford, England)

Increased prevalence and incidence of statin-associated immune-mediated necrotizing myopathy in Native Americans.

Clinics (Sao Paulo, Brazil)

Effects of a moderate combined exercise program on cognitive function, quality of life, and glycemic profile in older adults with type II diabetes mellitus.

Journal of proteome research

A Robust Multivariate Approach Unveils a 1H-NMR-Based Spectral Metabolomics Signature Predictive of Cardiovascular Disease in People with Type 2 Diabetes: A Prospective [email protected] Cohort Study.

[Aggressive course of ectopic ACTH syndrome due to adrenal medulla hyperplasia. Case report].

Terapevticheskii arkhiv

The Journal of international medical research

A rare case of H syndrome with severe multisystem involvement: Clinical challenges in low-resource healthcare settings.

Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc

Hyperbaric Oxygenation Therapy as Adjunctive Treatment of Complex Wound Associated with Sterno-clavicular Septic Arthritis.

Statin-Associated Immune-Mediated Necrotizing Myopathy With Dual Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase (Anti-HMGCR) and Anti-OJ Positivity: A Case Report of Fulminant Weakness and Respiratory Failure.

Low muscle strength and mortality: Key risk factors in the National Health and Nutrition Examination Survey retrospective cohort study.

Medicine

Muscle-Bone Crosstalk and Metabolic Dysregulation in Children and Young People Affected with Type 1 Diabetes: Mechanisms and Clinical Implications.

Cells

[Multiple pyomyositis and prostatic abscess in a patient with poorly controlled diabetes mellitus].

Medicina

Journal of ethnopharmacology

Amelioration of diabetic myopathy by APMCG-1: A mountain-cultivated ginseng-derived glycopeptide evaluated in zebrafish and mouse models.

European journal of medical research

Unraveling the causality between carpal tunnel syndrome and trigger finger through genetic instrumental variables.

Morphofunctional parameters as predictors of autologous hematopoietic stem cell transplantation outcomes.

Frontiers in nutrition

Acta medica (Hradec Kralove)

Myosteatosis and Type 2 Diabetes Mellitus.

Prevalence of Musculoskeletal Disorders Among People Living With Type 2 Diabetes in the Western Region of Saudi Arabia: A Cross-Sectional Study.

Advanced Gene-Expression Analysis of Skeletal Muscles Focusing on Normal, Glucose-Intolerant, and Diabetic Individuals with Type 2 Diabetes.

Biomedicines

Factitiously Low Total Creatine Kinase Activity in Severe Rhabdomyolysis: A Case Series.

Prague medical report

MRI characteristics of plantar fibromas: a large consecutive series from a tertiary care center with symptom analysis.

Skeletal radiology

Molecular and Immunomodulatory Mechanisms of Statins in Inflammation and Cancer Therapeutics with Emphasis on the NF-κB, NLRP3 Inflammasome, and Cytokine Regulatory Axes.

Journal of clinical ultrasound : JCU

Comparison of Ultrasonographic Features Among Healthy Individuals and Patients With Trigger Finger.

Journal of the American College of Cardiology

Safety and Effectiveness of Statins for Primary Prevention in Adults With Type 1 Diabetes: An Emulation.

Journal of diabetes investigation

Association between diabetic peripheral neuropathy and lower limb muscle strength in patients with type 2 diabetes mellitus: A systematic review and meta-analysis.

Medicine and science in sports and exercise

Role of LPC 18:1 in the Lipid Metabolic Response to Combined Vitamin D and Resistance Exercise for Protecting Diabetic Skeletal Muscle Function.

Radiologie (Heidelberg, Germany)

A comprehensive MRI-based study on adhesive capsulitis and its correlations with tendinosis and systemic diseases.

Rheumatology international

Musculoskeletal pain in an ageing population: a cross-sectional analysis of the Maastricht study.

My patient is taking a statin and is scheduled for surgery.

Casopis lekaru ceskych

Journal of neural transmission (Vienna, Austria : 1996)

Comorbid pathologies and their impact on progressive supranuclear palsy: current view.

The most common diagnoses in primary care, and changes over time, in the total population of Stockholm, Sweden.

BMC primary care

European journal of internal medicine

Effect of sodium-glucose cotransporter-2 inhibitors on skeletal muscle.

Rinsho shinkeigaku = Clinical neurology

[A case of recurrent cerebellitis leading to the diagnosis of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS)].

Orbit (Amsterdam, Netherlands)

Orbital necrotizing fasciitis due to Prevotella baroniae resulting in acute orbital compartment syndrome.

Mechanisms of skeletal muscle atrophy in type 2 diabetes mellitus.

Frontiers in physiology

Rheumatology (Oxford, England)

Frequency, diagnosis, and management of polymyalgia rheumatica in Germany-database analysis of medical insurance data.

Clinical hemorheology and microcirculation

The value of ultrasound in the evaluation of the type 2 diabetes mellitus related plantar fascia changes.

Journal of the Chinese Medical Association : JCMA

Incretin-based therapy: An update focusing on the major revolution in cardiovascular-kidney-metabolic health.

Genetics in medicine : official journal of the American College of Medical Genetics

Bi-allelic loss-of-function variants in POC5 cause a syndromic retinal, endocrine, and neuromuscular ciliopathy.

Upper-Limb Complications in Diabetes: A Narrative Review.

Diabetes care

Clinical orthopaedics and related research

How Does Tendon Region, Donor, and the Presence of Disease Affect Protein Composition of the Achilles Tendon?

Journal of medical ultrasound

Skeletal Muscle Ultrasound Radiomics and Machine Learning for the Earlier Detection of Type 2 Diabetes Mellitus.

Seminars in arthritis and rheumatism

Statin-associated immune-mediated necrotizing myopathy in Hispanic Americans.

Acute Kidney Injury and Chronic Kidney Disease Associated with a Genetic Defect: A Report of Two Cases.

The simple task of lifting five kilograms serves as a predictor of age-related disorders in old adults.

Involvement of impaired carnitine-induced fatty acid oxidation in experimental and human diabetic kidney disease.

JCI insight

Efficacy and Safety of Prolonged Treatment with Pemafibrate plus an HMG-CoA Reductase Inhibitor in Japanese Patients with Type 2 Diabetes Mellitus.

Drug research

Orphanet journal of rare diseases

Endocrine manifestations and long-term outcomes of patients with mitochondrial diseases.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

p16INK4a downregulation alleviates temporomandibular joint osteoarthritis combined with type 2 diabetes by driving M2 polarization.

Nutrition (Burbank, Los Angeles County, Calif.)

β-hydroxybutyrate attenuates diabetic renal and muscular pathologies in a streptozotocin-induced diabetic model.

The Journal of international medical research

Hemoadsorption combined with continuous venovenous hemodialyfiltration in a patient with Escherichia coli infection and severe diabetic ketoacidosis-associated rhabdomyolysis: A case report.

The Journal of clinical endocrinology and metabolism

Novel and Ultrarare Heterozygous Missense LMNA Variants Causing Familial Partial Lipodystrophy.

Journal of atherosclerosis and thrombosis

Comparative Effectiveness and Safety of Moderate-Intensity Pravastatin Versus Atorvastatin in Patients with Dyslipidemia: A Retrospective Cohort Study Using a Common Data Model of Multicenter Electronic Health Records in South Korea.

Advances in rheumatology (London, England)

Patients with overlapping dermatomyositis and psoriasis: an experience from a tertiary center and review of the literature.

Cerebellum (London, England)

Crossed Cerebellar Diaschisis in a Patient with MELAS Syndrome: A Case Report.

Carnitine Deficiency Caused by Salcaprozic Acid Sodium Contained in Oral Semaglutide in a Patient with Multiple Acyl-CoA Dehydrogenase Deficiency.

Medicine and science in sports and exercise

Maternal Physical Activity, Fitness, and Body Composition in Women with Gestational Diabetes: A Prospective Study.

Journal of investigative medicine high impact case reports

Diabetic Myonecrosis: Lessons in Recognizing and Treating a Rare Complication.

Beyond Bone Remodeling: Denosumab's Multisystemic Benefits in Musculoskeletal Health, Metabolism, and Age-Related Diseases-A Narrative Review.

Biomedicines

Diverse Phenotypes of Mitochondrial Disease With Varying Levels of Heteroplasmy.

JCEM case reports

Medicina (Kaunas, Lithuania)

Role of DPP-4 and NPY Family Peptides in Gastrointestinal Symptoms Associated with Obesity and Type 2 Diabetes Mellitus.

Frontiers in clinical diabetes and healthcare

Impact of vitamin D and vitamin D receptor activator in diabetic nephropathy.

Scandinavian journal of rheumatology

Cardiovascular risk and cardiac involvement in idiopathic inflammatory myopathies: insights from a cross-sectional Swedish single-centre study.

Archivos de la Sociedad Espanola de Oftalmologia

Retinopathy associated with MELAS syndrome. A case report.

High-intensity interval training alleviates STZ-induced muscle atrophy by restoration of nuclear positioning defects in C57BL/6 male mice.

New Insights on the miRNA Role in Diabetic Tendinopathy: Adipose-Derived Mesenchymal Stem Cell Conditioned Medium as a Potential Innovative Epigenetic-Based Therapy for Tendon Healing.

Biomolecules

Free radical biology & medicine

Deuterium-reinforced polyunsaturated fatty acids protect against muscle atrophy by STZ-induced diabetic mice.

The Journal of rheumatology

Characteristics of Overlap Syndrome in a Large Cohort of Brazilian Patients With Systemic Sclerosis: A Retrospective Analysis.

Is Obesity a Risk Factor for Developing Trigger Finger? A Case-Control Analysis of 198 804 Patients.

Hand (New York, N.Y.)

Advanced healthcare materials

Polyphenol-Modified Mg-Zn Layered Hydroxide-Contained Microneedle Patch Enhance Mucosal Repair by Remolding Diabetic Oral Microenvironment.

Clinical nutrition (Edinburgh, Scotland)

Feasibility challenges in protein supplementation research: Insights from the convalescence of functional outcomes after intensive care unit stay in a Randomised Controlled Trial.

The Journal of physiology

Physiological mechanisms of neuromuscular impairment in diabetes-related complications: Can physical exercise help prevent it?

The Journal of the Association of Physicians of India

Two Concerns and A Single Solution in Managing Type 2 Diabetes: A Narrative Review on Imeglimin.

The association of muscle weakness with functional disability in older patients with Diabetes mellitus: Measured by three different grip strength thresholds.

Reviews in endocrine & metabolic disorders

Exploring the relationship between glycemic variability and muscle dysfunction in adults with diabetes: A systematic review.

Journal of cachexia, sarcopenia and muscle

Aptamer-Conjugated Exosomes Ameliorate Diabetes-Induced Muscle Atrophy by Enhancing SIRT1/FoxO1/3a-Mediated Mitochondrial Function.

Enhancing diabetic muscle repair through W-GA nanodots: a nanomedicinal approach to ameliorate myopathy in type 2 diabetes.

Burns & trauma

The Role of microRNA-22 in Metabolism.

Type 2 Diabetes Induces Mitochondrial Dysfunction in Zebrafish Skeletal Muscle Leading to Diabetic Myopathy via the miR-139-5p/NAMPT Pathway.

Molecular and cellular endocrinology

Skeletal muscle disorders as risk factors for type 2 diabetes.

Cardiovascular diabetology

ICAM1 blockade improves ischemic muscle reperfusion in diabetic mice.

Inquiry : a journal of medical care organization, provision and financing

The Predictors of Dietary Supplement Use Among Women With Musculoskeletal Disease: A Population-Based Complex Sample Designed Study.

Journal of vascular surgery cases and innovative techniques

A novel technique for external iliac artery reconstruction in renal transplant patients with extensively atherosclerotic lower limb vasculature.

Journal of applied physiology (Bethesda, Md. : 1985)

Timing of resistance exercise and cardiometabolic outcomes in adults with prediabetes: a secondary analysis.

The Lancet regional health. Europe

Association between cardiometabolic diseases and the risk and progression of motor neuron diseases in Sweden: a population-based case-control study.

Documenta ophthalmologica. Advances in ophthalmology

Anti-VEGF therapy for proliferative diabetic retinopathy in Kearns-Sayre syndrome.

Secondary Polymyalgia Rheumatica Following SARS-CoV-2 Infection.

Acta medica Okayama

Hormone research in paediatrics

Thyrotoxic Hypokalemic Periodic Paralysis Induced by High-Dose Insulin in an Adolescent Male with Type 1 Diabetes Mellitus.

Regulation of injury-induced skeletal myofiber regeneration by glucose transporter 4 (GLUT4).

Skeletal muscle

Hypermucoviscous Klebsiella pneumoniae presenting as sternocleidomastoid pyomyositis with subsequent lower extremity necrotising fasciitis.

BMJ case reports

International journal of biological macromolecules

Development of a natural rubber latex-based biodevice with mesenchymal stem cells as a potential treatment for skeletal muscle regeneration in gestational diabetes-induced myopathy.

Expert opinion on drug safety

Real-world safety evaluation of atorvastatin: insights from the US FDA adverse event reporting system (FAERS).

American journal of physiology. Cell physiology

Altered sphingolipid profile in response to skeletal muscle injury in a mouse model of type 1 diabetes mellitus.

Journal of cachexia, sarcopenia and muscle

The Stimulator of Interferon Genes Deficiency Attenuates Diabetic Myopathy Through Inhibiting NLRP3-Mediated Pyroptosis.

Free radical biology & medicine

Muscle regeneration and muscle stem cells in metabolic disease.

Revista medica del Instituto Mexicano del Seguro Social

[Negative pressure therapy as complementary treatment in tropical diabetic hand syndrome].

International journal of obesity (2005)

Exploring differential miRNA expression profiles in muscular and visceral adipose tissue of patients with severe obesity.

BMC musculoskeletal disorders

Investigating the mechanism of supraspinatus tendinopathy induced by type 2 diabetes mellitus in rats using untargeted metabolomics analysis.

Antioxidants (Basel, Switzerland)

Baicalein Ameliorates Insulin Resistance of HFD/STZ Mice Through Activating PI3K/AKT Signal Pathway of Liver and Skeletal Muscle in a GLP-1R-Dependent Manner.

Increased risk of adverse events among patients with vs. without systemic autoimmune rheumatic disease prescribed sodium-glucose cotransporter 2 inhibitors: a retrospective cohort study.

Clinical rheumatology

No Muscle Left Behind: Cardiac Arrest and Myocarditis in a Patient With Idiopathic Inflammatory Myopathy.

Archives of endocrinology and metabolism

Phenotypic and molecular reanalysis of a cohort of patients with monogenic diabetes reveals a case of partial lipodystrophy due to the A8344G mutation in the mitochondrial DNA.

Psychotherapy and psychosomatics

Study of Rates and Factors Associated to Psychosomatic Syndromes Assessed Using the Diagnostic Criteria for Psychosomatic Research across Different Clinical Settings.

Metformin modulates the TXNIP-NLRP3-GSDMD pathway to improve diabetic bladder dysfunction.

[The diabetic hand - a forgotten complication].

Lakartidningen

Medicina (Kaunas, Lithuania)

Deciphering the Role of Maternal Microchimerism in Offspring Autoimmunity: A Narrative Review.

Orthopadie (Heidelberg, Germany)

[Dupuytren's disease : Epidemiology, diagnosis, treatment, outcome].

WMJ : official publication of the State Medical Society of Wisconsin

Tropical Myositis: A Not-So-Tropical Diagnosis in a Febrile Type 1 Diabetic Patient.

Cardiovascular diabetology

Fenofibrate to prevent amputation and reduce vascular complications in patients with diabetes: FENO-PREVENT.

Medicina (Kaunas, Lithuania)

Exploring the Overlooked Depression, Anxiety, Insomnia and Fibromyalgia Syndrome Burden in Arab Women with Type 2 Diabetes: New Avenues for Chronic Disease Management.

Wolfram Syndrome 1: A Neuropsychiatric Perspective on a Rare Disease.

Genes

Studies in health technology and informatics

Strategies to Address Statin Medication Intolerance Among Patients at Risk of Cardiovascular Disease Identified Through Electronic Health Records: A Literature Review and Pooled Analysis.

Retinal cases & brief reports

LONG-TERM FOLLOW-UP OF A FAMILY WITH A3243G MITOCHONDRIAL SYNDROME.

Cardiovascular diabetology

Data-independent LC-MS/MS analysis of ME/CFS plasma reveals a dysregulated coagulation system, endothelial dysfunction, downregulation of complement machinery.

Scandinavian journal of rheumatology

Ultrasonographic findings in diabetic cheiroarthropathy: a pilot study.

The Journal of the Association of Physicians of India

Responsible Use of Oral Corticosteroids in People with Comorbid Diabetes: An Expert Consensus.

The American journal of the medical sciences

Diabetes with GLP-1R polymorphism (rs3765467) accompanied by myotonic dystrophy: A case of myotonic dystrophy with p.R131Q polymorphism at the glucagon-like peptide-1 receptor (rs3765467) resulting in marked effects of its agonist, dulaglutide.

[A case report of a MODY 10 family presenting as hypokalemic periodic paralysis].

Zhonghua nei ke za zhi

Shoulder muscle weakness and proprioceptive impairments in type 2 diabetes mellitus: exploring correlations for improved clinical management.

PeerJ

Systemic Deletion of ARRDC4 Improves Cardiac Reserve and Exercise Capacity in Diabetes.

Circulation research

Journal of medical case reports

Diabetic myonecrosis complicated by emphysematous pyomyositis and abscess caused by Escherichia coli: a case report.

Orbit (Amsterdam, Netherlands)

A case of extraocular muscle pyomyositis in an elderly patient with diabetes mellitus.

Clinical and experimental rheumatology

Effect of fibromyalgia on demographic, biochemical, metabolic and inflammatory profiles: a single-centre retrospective study.

Contribution of circulating Mfge8 to human T2DM and cardiovascular disease.

Gene

European heart journal. Case reports

Inflammatory-mediated atrial cardiomyopathy diagnosed using multimodality imaging and successfully treated with prednisolone: a case report.

Comparative study on muscle function in two different streptozotocin-induced diabetic models.

Acta diabetologica

Type 2 diabetes mellitus related sarcopenia: a type of muscle loss distinct from sarcopenia and disuse muscle atrophy.

The American journal of case reports

Clinical Progression and Manifestations of H Syndrome: A Case Report of Failed Treatment Option.

Journal of clinical medicine

Sarcopenia Prevalence among Hospitalized Patients with Severe Obesity: An Observational Study.

An RNA-seq study in Friedreich ataxia patients identified hsa-miR-148a-3p as a putative prognostic biomarker of the disease.

Human genomics

Journal of plastic, reconstructive & aesthetic surgery : JPRAS

Identifying non-genetic factors associated with trigger finger.

Targeting skeletal muscle health with exercise in people with type 1 diabetes: A protocol for HOMET1D, a prospective observational trial with matched controls.

Mitochondrial fatty acid beta-oxidation: a possible therapeutic target for skeletal muscle lipotoxicity in peripheral artery disease myopathy.

EXCLI journal

Archives of orthopaedic and trauma surgery

Current research trends on the effect of diabetes mellitus on rotator cuff tendon healing/tendinopathy.

Targeting Molecular Mechanisms of Obesity- and Type 2 Diabetes Mellitus-Induced Skeletal Muscle Atrophy with Nerve Growth Factor.

Expert review of endocrinology & metabolism

Methods to predict heart failure in diabetes patients.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

Myotonic dystrophy type 1 in South Korea: a comprehensive analysis of cancer and comorbidity risks.

Gene expression alterations of purinergic signaling components in obesity-associated intestinal low-grade inflammation in type 2 diabetes.

Purinergic signalling

Mymensingh medical journal : MMJ

Developments in Hand Surgery: Experience from a Tertiary Hospital of Northern Bangladesh.

The lancet. Diabetes & endocrinology

Effects of statin therapy on diagnoses of new-onset diabetes and worsening glycaemia in large-scale randomised blinded statin trials: an individual participant data meta-analysis.

Archives of orthopaedic and trauma surgery

Delayed debridement affects prognosis in patients with purulent flexor tenosynovitis: a retrospective cohort and multivariate analyses.

GC-MS analysis of 4-hydroxyproline: elevated proline hydroxylation in metformin-associated lactic acidosis and metformin-treated Becker muscular dystrophy patients.

Amino acids

Respiration; international review of thoracic diseases

The Association between Objectively Measured Physical Activity and the Prevalence of Comorbidities in Lung Transplant Recipients.

Impact of L-Arginine on diabetes-induced neuropathy and myopathy: Roles of PAI-1, Irisin, oxidative stress, NF-κβ, autophagy and microRNA-29a.

Tissue & cell

Journal of immunology (Baltimore, Md. : 1950)

Murine MHC-Deficient Nonobese Diabetic Mice Carrying Human HLA-DQ8 Develop Severe Myocarditis and Myositis in Response to Anti-PD-1 Immune Checkpoint Inhibitor Cancer Therapy.

Potential Benefits and Risks Associated with the Use of Statins.

Pharmaceutics

The Tohoku journal of experimental medicine

Risk of Hemorrhagic Stroke among Patients Treated with High-Intensity Statins versus Pitavastatin-Ezetimibe: A Population Based Study.

Diabetes, obesity & metabolism

Evaluating different low-density lipoprotein cholesterol thresholds to initiate statin for prevention of cardiovascular diseases in patients with type 2 diabetes mellitus: A target trial emulation study.

Progress in molecular biology and translational science

RNA therapeutics for treatment of diabetes.

Renal manifestations in adults with mitochondrial disease from the mtDNA m.3243A>G pathogenic variant.

Nefrologia

Molecules (Basel, Switzerland)

MCC950 Ameliorates Diabetic Muscle Atrophy in Mice by Inhibition of Pyroptosis and Its Synergistic Effect with Aerobic Exercise.

Incidence, Prevalence, and Outcomes of Hand Manifestations in Patients With Diabetes Mellitus: A Comprehensive Literature Review.

Hand (New York, N.Y.)

Journal of the American Pharmacists Association : JAPhA

Rhabdomyolysis and acute kidney injury potentiated by a drug-drug interaction between cyclosporine, leflunomide, and rosuvastatin in a kidney transplant recipient: A missed opportunity for pharmacist involvement.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

A case of exacerbated encephalopathy with stroke-like episodes and lactic acidosis triggered by metformin in a patient with MELAS.

Pediatric rheumatology online journal

Rheumatological complaints in H syndrome: from inflammatory profiling to target treatment in a case study.

Pathogenesis and comprehensive treatment strategies of sarcopenia in elderly patients with type 2 diabetes mellitus.

Journal of biomolecular structure & dynamics

Structural insights into the interactions of repositioning and known drugs for Alzheimer's disease with hen egg white lysozyme by MM-GBSA.

American journal of medical genetics. Part A

Metabolic and other morbid complications in congenital generalized lipodystrophy type 4.

Spontaneous tendon or ligament ruptures in patients undergoing dialysis: First pediatric case report and literature review.

Seminars in dialysis

Ameliorating impact of coenzyme Q10 on the profile of adipokines, cardiomyopathy, and hematological markers correlated with the glucotoxicity sequelae in diabetic rats.

International journal of epidemiology

Hyperglycaemia is a causal risk factor for upper limb pathologies.

Neuromuscular disorders : NMD

Neutral lipid storage disease with myopathy: clinicopathological and genetic features of nine Iranian patients.

Improvement of Intestinal Pseudo-Obstruction by Total Parenteral Nutrition in a Young Woman With Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes: A Case Report.

Age and sex differences in comorbidities in adult temporomandibular disorders: A cross-sectional study using Korea National Health and Nutrition Examination Survey (KNHANES).

Beyond the Cardiovascular Effects of Glucagon-like Peptide-1 Receptor Agonists: Body Slimming and Plaque Stabilization. Are New Statins Born?

Biomolecules

Experimental cell research

Equilibrative nucleotide transporter ENT3 (SLC29A3): A unique transporter for inherited disorders and cancers.

Effects of socioeconomic status on patient-reported outcome after surgically treated trigger finger: a retrospective national registry-based study.

BMJ open

American journal of physiology. Heart and circulatory physiology

Empagliflozin treatment rescues abnormally reduced Na+ currents in ventricular cardiomyocytes from dystrophin-deficient mdx mice.

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society

Myotonic dystrophy type 1 (Steinert disease): 29 years of experience at a tertiary pediatric hospital.

Changing spectrum of primary pyomyositis in North India.

Tropical doctor

Deletion of the muscle enriched lncRNA Oip5os1 induces atrial dysfunction in male mice with diabetes.

Physiological reports

Identifying Acss1, Mtfp1 and Oxct1 as key regulators and promising biomarkers of sarcopenia in various models.

Gene

Journal of clinical medicine

Optimal Management of Patients with Phlegmonous Esophagitis: A Systematic Review and Meta-Analysis.

Diabetes, obesity & metabolism

Sex-specific associations between skeletal muscle mass and incident diabetes: A population-based cohort study.

Journal of molecular medicine (Berlin, Germany)

A gene therapy targeting medium-chain acyl-CoA dehydrogenase (MCAD) did not protect against diabetes-induced cardiac pathology.

Molecular biology reports

Intra-articular site-specific distribution of advanced glycation end products in the shoulder of patients with diabetes mellitus having rotator cuff tears.

Therapeutic potential of ginsenoside compound K in managing tenocyte apoptosis and extracellular matrix damage in diabetic tendinopathy.

Tissue & cell

The Journal of family practice

55-year-old woman • Myalgias and progressive symmetrical proximal weakness • History of unilateral renal agenesis, type 2 diabetes, and hyperlipidemia • Dx?

Causal influence of muscle weakness on cardiometabolic diseases and osteoporosis.