É um tipo de doença transmitida por carrapatos que aparece na pele, causada por bactérias do gênero Rickettsia.
Introdução
O que você precisa saber de cara
É um tipo de doença transmitida por carrapatos que aparece na pele, causada por bactérias do gênero Rickettsia.
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Entender a doença
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 9 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 26 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Nenhum gene associado encontrado
Os dados genéticos desta condição ainda estão sendo catalogados.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Febre macular por rickettsiose
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Publicações mais relevantes
Rickettsia parkeri genetic diversity from three different hard tick species (family: Ixodidae).
Rickettsia parkeri sensu stricto, a causative agent of spotted fever rickettsiosis, is spread via the bite of infected ticks within the Amblyomma maculatum complex group. In the United States of America (USA), Am. maculatum Koch, 1844 is the primary vector for R. parkeri; however, Amblyomma americanum (Linnaeus, 1758) and Dermacentor variabilis (Say, 1821) have demonstrated potential to transmit R. parkeri under laboratory conditions. In this study, we investigate the genetic differences between R. parkeri detected in Am. maculatum, the primary enzootic vector, and potential secondary vectors - Am. americanum and De. variabilis. Using Nanopore long-read amplicon sequencing, we compared four R. parkeri genes amplified from naturally infected Am. maculatum, Am. americanum, and De. variabilis collected in the USA. Three R. parkeri genes associated with potential virulence factors were sequenced: outer membrane protein A (OmpA/sca0), outer membrane protein B (OmpB/sca5), and surface cell antigen 4 (gene D/sca4). One species-level gene target was used for species confirmation: 16S ribosomal RNA gene (16S). Differences in cellular-entry and pathogen chromosomal genes (OmpA, OmpB, and 16S) were detected within the different tick species. No differences were noted in the cell-to-cell mediated transfer gene (gene D) between tick species. This preliminary study suggests that infection in Am. americanum may lead to changes in R. parkeri genes responsible for pathogen-host cell attachment and replication processes, but once established in a host cell, R. parkeri transfer between cells is unlikely to be impacted.
High prevalence of the Mediterranean spotted fever agent Rickettsia aeschlimannii in Hyalomma marginatum ticks from Pianosa island, Italy.
Tick-borne rickettsioses, caused by bacteria of the spotted fever group (SFG) Rickettsia, are emerging infectious diseases whose emergence and spread are often affected by climate and land-use changes. Here, we report the results of monitoring Hyalomma spp. ticks in the protected area of Pianosa island (Tuscany (Italy) and subsequently investigating their bacterial community through metabarcoding sequencing. In this study, based on analyses of 575 tick specimens distributed in 120 pools, we recorded a high prevalence of Rickettsia aeschlimannii (58% and 75% gltA- and 17 kDa-Ag protein-positive pools, respectively), an agent of the SFG group in H. marginatum. These findings support the need for warnings on the risk of transmission of spotted fever rickettsiosis to both residents and visitors and underline the need for enhanced surveillance, public awareness and preventive measures.
Completion of Paired Serological Testing Algorithms for Spotted Fever Rickettsiosis and Ehrlichiosis, North Carolina: 2017-2020.
Ehrlichia and Rickettsia are tickborne pathogens capable of causing severe disease. Paired serological testing, involving both acute and convalescent samples, remains the primary method of diagnostic confirmation and source of surveillance data. Yet, few patients complete recommended testing algorithms. We examined the demographic, clinical, and geographic factors associated with obtainment of convalescent samples for patients with suspected ehrlichiosis and spotted fever rickettsiosis using results from a large academic center in North Carolina between 2017 and 2020. More than 4400 patients underwent serological testing of an acute sample for Rickettsia (N = 4224) and Ehrlichia (N = 2339); however, only 15.0% (662/4415) had testing performed on a convalescent sample. Over the study period, the proportion of convalescent testing completed increased from 4% to 23% for Ehrlichia, 7% to 11% for Rickettsia, and 12% to 28% for both. A reactive test on the acute sample, undergoing testing for both pathogens, and proximity to a health facility were significantly associated with obtainment and testing of a convalescent sample. The presence of a reactive acute titer for Ehrlichia and Rickettsia had 8.3 (95% confidence interval, 6.3-10.9) and 8.2 (95% confidence interval, 6.5-10.3) times the probability of obtainment of a convalescent sample compared to nonreactive results, respectively. Our findings suggest that clinicians' knowledge of tickborne disease testing practices, in addition to patient distance to health facilities, contribute to poor performance of testing completion. Moreover, these results highlight the need for more investment in public health surveillance and, ultimately, assays that are not dependent on convalescent testing.
Seroprevalence of spotted fever rickettsiosis and ehrlichiosis among food processing workers and their families in Latino communities in North Carolina.
Workers in food processing industries are subject to many occupational health risks and disparities, but little is known about their risk of tickborne diseases. We examined a cohort of Latino individuals working in the meat packing, produce processing, and farming industries and their family members in central North Carolina, where incidence of tickborne infections is high. Blood samples were tested for IgG antibodies against Spotted Fever Group Rickettsiosis (SFGR) and Ehrlichia chaffeensis. Covariates of interest included age, sex, primary language, work industry, indoor vs. outdoor work, home characteristics, medical comorbidities, and travel history. Among 201 Latino food processing workers and their family members, the seroprevalence of SFGR and Ehrlichia was 14.9% and 19.9%, respectively. Almost a third of participants were seropositive for at least one infection. SFGR seropositive individuals were significantly older than seronegative individuals (median 45 [interquartile range 35-55] vs. 33 [14-45] years, p < 0.001), while Ehrlichia seropositivity appeared to have a bimodal distribution by age, with peaks in children under age 10 and adults in their forties and fifties. Farm workers had higher seroprevalence of SFGR (25.0%) than other workers (13.5%), although this did not reach statistical significance (p = 0.13). Having a seropositive household member for either infection was a risk factor for seropositivity for the same infection, adjusted for age and household clustering (adjusted OR [aOR] 8.26, 95% CI [confidence interval] 3.27-20.90 for SFGR; aOR 11.24, 95% CI 4.24-29.80 for Ehrlichia). Seroprevalence for SFGR and Ehrlichia was similar between index workers and household members when adjusted for age. Our findings indicate that Latino food processing communities in North Carolina have high exposure to tickborne disease, and older age and having seropositive household members are key risk factors.
Spatial and clinical epidemiology of spotted fever rickettsioses and ehrlichiosis, North Carolina, 2010-2019.
North Carolina (NC) ranks among the top five states for spotted fever rickettsiosis (SFR) cases and second for ehrlichiosis in the U.S. Identifying geographic clusters of cases is important to elucidate disease risk and inform public health response, including resource allocation. This study examined geographic patterns of tick-borne disease incidence in NC over a 10-year period and modeled predictors of disease severity. We analyzed 6,748 SFR and 1,216 ehrlichiosis cases reported to the NC Electronic Disease Surveillance System between January 2010 and December 2019. Average annual incidence was evaluated in two-year periods using global spatial autocorrelation (Moran's I) and Local Indicator of Spatial Association. We found that ehrlichiosis clusters were detected in north and central NC as well as the coastal Tidewater region, with consistently high incidence in these areas. SFR clustering occurred in similar areas, with high and increasing incidence statewide. Severe cases of ehrlichiosis followed a similar pattern, while severe SFR clusters were distributed more broadly across the state. Additionally, Black/African-American individuals made up a greater proportion of both severe ehrlichiosis and SFR cases relative to non-severe cases. Regression models showed that known tick exposures were associated with lower odds of severe SFR. For SFR, treatment delays of 1-7 days were linked to severity, but delays >7 days were not. In contrast, delays >7 days for ehrlichiosis were associated with lower odds of severe disease. Associations found here between severity and treatment delay may reflect care-seeking behaviors, testing practices, and background seroprevalence. Geographic differences in disease incidence and severity warrant further investigation and future surveillance. Public health interventions should focus on the north-central and Tidewater regions, focusing on exposure risks awareness for outdoor activities and checking for ticks, which could impact treatment timing and ultimately reduce severity.
Publicações recentes
Secondary Hemophagocytic Lymphohistiocytosis in a Rocky Mountain Spotted Fever Patient.
Molecular identification and phylogenetic analysis of spotted fever Rickettsiae in peripheral blood from suspected Rickettsiosis cases in Sri Lanka.
Rickettsia parkeri genetic diversity from three different hard tick species (family: Ixodidae).
High prevalence of the Mediterranean spotted fever agent Rickettsia aeschlimannii in Hyalomma marginatum ticks from Pianosa island, Italy.
Anti-Rickettsial Activity of Chitosan, Selenium, and Silver Nanoparticles: Efficacy in Vero Cells.
📚 EuropePMC47 artigos no totalmostrando 75
Rickettsia parkeri genetic diversity from three different hard tick species (family: Ixodidae).
Parasites & vectorsHigh prevalence of the Mediterranean spotted fever agent Rickettsia aeschlimannii in Hyalomma marginatum ticks from Pianosa island, Italy.
Parasites & vectorsAnti-Rickettsial Activity of Chitosan, Selenium, and Silver Nanoparticles: Efficacy in Vero Cells.
Pathogens (Basel, Switzerland)Seroprevalence of spotted fever rickettsiosis and ehrlichiosis among food processing workers and their families in Latino communities in North Carolina.
PLOS global public healthSpatial and clinical epidemiology of spotted fever rickettsioses and ehrlichiosis, North Carolina, 2010-2019.
PLoS neglected tropical diseasesDetection of Rickettsia-Infected Argas (Persicargas) giganteus on Osprey (Pandion haliaetus) from the Northeastern USA.
Journal of wildlife diseasesSeroprevalence of spotted fever group rickettsiosis in Kashmir: A community-based study using indirect immunofluorescence assay.
Indian journal of medical microbiologyEnhanced surveillance for tick-borne rickettsiosis and ehrlichiosis in North Carolina: Protocol and preliminary results.
PloS oneCharacterization of Transstadial Transmission of Rickettsia Amblyommatis in Haemaphysalis Longicornis Using Optimized Artificial Membrane Feeding System.
The American journal of tropical medicine and hygieneRickettsia Felis Case Cluster in a Military Family.
Military medicineCompletion of Paired Serological Testing Algorithms for Spotted Fever Rickettsiosis and Ehrlichiosis, North Carolina: 2017-2020.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of AmericaDevelopment of a Recombinase-Mediated Cassette Exchange System for Gene Knockout and Expression of Non-Native Gene Sequences in Rickettsia.
VaccinesDetection of Amblyomma maculatum and Rickettsia parkeri in prairies of Central Missouri.
Veterinary parasitology, regional studies and reportsSimilarities between Ixodes ricinus and Ixodes inopinatus genomes and horizontal gene transfer from their endosymbionts.
Current research in parasitology & vector-borne diseasesLimited evidence of infection with other tick-borne pathogens in patients tested for Lyme neuroborreliosis in the Netherlands.
Ticks and tick-borne diseasesThe natural history of Amblyomma maculatum sensu lato, a vector of Rickettsia parkeri rickettsiosis, in southern Arizona.
Scientific reportsSpatial and temporal variation of five different pathogens and symbionts in Ixodes ricinus nymphs in the Netherlands.
Current research in parasitology & vector-borne diseasesRickettsia parkeri Rickettsiosis in Kidney Transplant Recipient, North Carolina, USA, 2023.
Emerging infectious diseasesIdentification of Bacteria and Viruses Associated with Patients with Acute Febrile Illness in Khon Kaen Province, Thailand.
VirusesBenidipine impairs innate immunity converting sublethal to lethal infections in a murine model of spotted fever rickettsiosis.
PLoS neglected tropical diseasesScience abhors a surveillance vacuum: Detection of ticks and tick-borne pathogens in southern New Mexico through passive surveillance.
PloS oneSusceptibility of Amblyomma sculptum, Vector of Rickettsia rickettsii, Ticks from a National Park and an Experimental Farm to Different Synthetic Acaricides.
Pathogens (Basel, Switzerland)Spotted fever rickettsioses. Study of cases reported in a secondary care pediatric hospital of northeastern Mexico, 2012-2022.
Gaceta medica de Mexico[Spotted fever rickettsioses. Study of cases reported in a secondary care pediatric hospital of northeastern Mexico, 2012-2022].
Gaceta medica de MexicoTick-Borne Pathogens Associated with Medically Important Ticks in Alabama: A Four-Year Survey.
Vector borne and zoonotic diseases (Larchmont, N.Y.)Evaluating the Clinical and Immune Responses to Spotted Fever Rickettsioses in the Guinea Pig-Tick-Rickettsia System.
Current protocolsDetection of Rickettsia montanensis in Dermacentor variabilis in Northern Wisconsin.
Vector borne and zoonotic diseases (Larchmont, N.Y.)Quantitative microbial population study reveals geographical differences in bacterial symbionts of Ixodes ricinus.
MicrobiomeMapping potential risks for the transmission of spotted fever rickettsiosis: The case study from the Rio de Janeiro state, Brazil.
PloS oneMultiplex TaqMan® Quantitative PCR Assays for Host-Tick-Pathogen Studies Using the Guinea Pig-Tick-Rickettsia System.
Pathogens (Basel, Switzerland)Incidence Rate of Somatic Dysfunction in Previously Undiagnosed Spotted Fever Rickettsiosis: A Case Report.
CureusDiagnostic Value of IgA Antibody Measurement in Tick-Borne Spotted Fever (Astrakhan Rickettsial Fever).
Microbiology spectrumCollaborating With Community Scientists Across Arkansas to Update Tick Distributions and Pathogen Prevalence of Spotted Fever Group Rickettsia and Ehrlichia.
Journal of medical entomologyPatient characteristics, treatment patterns, and outcomes of Rickettsial diseases among a commercially insured population in the United States, 2005-2017.
Scientific reportsAssessing scrub typhus and rickettsioses transmission risks in the Chiang Rai province of northern Thailand.
Travel medicine and infectious diseaseBeyond the IFA: Revisiting the ELISA as a More Sensitive, Objective, and Quantitative Evaluation of Spotted Fever Group Rickettsia Exposure.
Pathogens (Basel, Switzerland)MicroRNA-424 regulates the expression of CX3CL1 (fractalkine) in human microvascular endothelial cells during Rickettsia rickettsii infection.
Biochemistry and biophysics reportsRickettsia parkeri (Rickettsiales: Rickettsiaceae) detected in Amblyomma maculatum ticks collected on dogs in Tabasco, Mexico.
Experimental & applied acarologyAcute infectious purpura fulminans: a case series from India.
Tropical doctorOptimization and Evaluation of a Multiplex Quantitative PCR Assay for Detection of Nucleic Acids in Human Blood Samples from Patients with Spotted Fever Rickettsiosis, Typhus Rickettsiosis, Scrub Typhus, Monocytic Ehrlichiosis, and Granulocytic Anaplasmosis.
Journal of clinical microbiologyEmerging tick-borne pathogens of public health importance: a mini-review.
Journal of medical microbiologySpotted fever rickettsiosis presenting with bilateral anterior uveitis and retinitis: A case report.
Journal of family medicine and primary careRickettsia parkeri (Rickettsiales: Rickettsiaceae) in the Sky Islands of West Texas.
Journal of medical entomologyEvaluation of Disease Causality of Rare Ixodes ricinus-Borne Infections in Europe.
Pathogens (Basel, Switzerland)Surveillance for Amblyomma maculatum (Acari: Ixodidae) and Rickettsia parkeri (Rickettsiales: Rickettsiaceae) in the State of Delaware, and Their Public Health Implications.
Journal of medical entomologyAn optimized five-color/seven-parameter flow cytometry panel for immunophenotyping guinea pig peripheral blood lymphocytes.
Journal of immunological methodsExpanding Recognition of Rickettsia parkeri Rickettsiosis in Southern Arizona, 2016-2017.
Vector borne and zoonotic diseases (Larchmont, N.Y.)A human case of spotted fever caused by Rickettsia parkeri strain Atlantic rainforest and its association to the tick Amblyomma ovale.
Parasites & vectorsMeningoencephalitis due to Spotted Fever Rickettsioses, Including Rocky Mountain Spotted Fever.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of AmericaPhenology of Amblyomma sculptum in a degraded area of Atlantic rainforest in north-eastern Brazil.
Ticks and tick-borne diseasesAntibody Titers Reactive With Rickettsia rickettsii in Blood Donors and Implications for Surveillance of Spotted Fever Rickettsiosis in the United States.
The Journal of infectious diseasesA biosafety level-2 dose-dependent lethal mouse model of spotted fever rickettsiosis: Rickettsia parkeri Atlantic Rainforest strain.
PLoS neglected tropical diseasesMolecular evidence of Borrelia burgdorferi sensu stricto and Rickettsia massiliae in ticks collected from a domestic-wild carnivore interface in Chihuahua, Mexico.
Ticks and tick-borne diseasesHLA-B27 spondyloarthritis and spotted fever rickettsiosis: case-based review.
Rheumatology internationalLyme borreliosis and other tick-borne diseases. Guidelines from the French Scientific Societies (I): prevention, epidemiology, diagnosis.
Medecine et maladies infectieusesSpotted fever rickettsiosis in South Africa: Evaluation of laboratory diagnostic capacity and inter-laboratory comparison of serological testing.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskundeNational Surveillance Data Show Increase in Spotted Fever Rickettsiosis: United States, 2016-2017.
American journal of public healthAmblyomma maculatum-associated rickettsiae in vector tissues and vertebrate hosts during tick feeding.
Experimental & applied acarologySevere leptospirosis in a patient with positive serological test for spotted fever rickettsiosis.
BMJ case reportsAttempt to uncover reservoirs of human spotted fever rickettsiosis on the Fleurieu Peninsula, South Australia.
Journal of vector borne diseasesVector Tick Transmission Model of Spotted Fever Rickettsiosis.
The American journal of pathologySpotted Fever Rickettsiosis in a Wildlife Researcher in Sabah, Malaysia: A Case Study.
Tropical medicine and infectious diseaseMediterranean spotted fever rickettsiosis in Italy, 2001-2015: Spatio-temporal distribution based on hospitalization records.
Ticks and tick-borne diseasesFatal spotted fever rickettsiosis in Argentina.
IDCasesFibroblast growth factor receptor-1 mediates internalization of pathogenic spotted fever rickettsiae into host endothelium.
PloS oneSeroepidemiology of Spotted Fever Rickettsiosis in Uttar Pradesh: A Prospective Study.
Journal of clinical and diagnostic research : JCDRRetrospective Case Reports of Two Central North Carolina Residents: Frequency of Tick Bites and Associated Illnesses, 2001-2014.
North Carolina medical journalComparative growth of spotted fever group Rickettsia spp. strains in Vero cells.
Memorias do Instituto Oswaldo CruzPrevalence of Rickettsia species in Dermacentor variabilis ticks from Ontario, Canada.
Ticks and tick-borne diseasesComparative value of blood and skin samples for diagnosis of spotted fever group rickettsial infection in model animals.
Ticks and tick-borne diseasesA Clinical Review of Tick-Borne Diseases in Arkansas.
The Journal of the Arkansas Medical SocietyEvaluation of a new serological test for the detection of anti-Coxiella and anti-Rickettsia antibodies.
Microbes and infectionRickettsia massiliae and Rickettsia conorii Israeli Spotted Fever Strain Differentially Regulate Endothelial Cell Responses.
PloS oneSpotted fever rickettsiosis in Uttar Pradesh.
The Indian journal of medical researchIncidence of notifiable diseases among American Indians/Alaska Natives - United States, 2007-2011.
MMWR. Morbidity and mortality weekly reportAssociações
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Rickettsia parkeri genetic diversity from three different hard tick species (family: Ixodidae).
- High prevalence of the Mediterranean spotted fever agent Rickettsia aeschlimannii in Hyalomma marginatum ticks from Pianosa island, Italy.
- Completion of Paired Serological Testing Algorithms for Spotted Fever Rickettsiosis and Ehrlichiosis, North Carolina: 2017-2020.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America· 2026· PMID 40176320mais citado
- Seroprevalence of spotted fever rickettsiosis and ehrlichiosis among food processing workers and their families in Latino communities in North Carolina.
- Spatial and clinical epidemiology of spotted fever rickettsioses and ehrlichiosis, North Carolina, 2010-2019.
- Secondary Hemophagocytic Lymphohistiocytosis in a Rocky Mountain Spotted Fever Patient.
- Molecular identification and phylogenetic analysis of spotted fever Rickettsiae in peripheral blood from suspected Rickettsiosis cases in Sri Lanka.
- Anti-Rickettsial Activity of Chitosan, Selenium, and Silver Nanoparticles: Efficacy in Vero Cells.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:102022(Orphanet)
- MONDO:0001195(MONDO)
- GARD:19828(GARD (NIH))
- Busca completa no PubMed(PubMed)
- Q9274700(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
