Cistite intersticial

The Study is Being Conducted to Find a New Treatment for Patients Suffering From Interstitial Cystitis With Hunner's Lesions

NCT07459790

The Study is Being Conducted to Find a New Treatment for Patients Suffering From Interstitial Cystitis Without Hunner's Lesions.

NCT07391306

EPPIC: Easing Pelvic Pain Interventions Clinical Research Program

NCT05127616

Safety, Efficacy, and Frequency of Administration of VNX001 in the Treatment of Interstitial Cystitis / Bladder Pain Syndrome (IC/BPS)

NCT06394830

Safety and Efficacy Study of VNX001 Compared to Its Individual Components (Lidocaine and Heparin) or Placebo in Subjects With IC/BPS

NCT05737121

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PHASE2, PHASE3

NCT07391306 · The Study is Being Conducted to Find a New Treatment for Pat…Recrutando

PHASE2, PHASE3

NCT05127616 · EPPIC: Easing Pelvic Pain Interventions Clinical Research Pr…Recrutando

NCT06394830 · Safety, Efficacy, and Frequency of Administration of VNX001 …Recrutando

NCT05737121 · Safety and Efficacy Study of VNX001 Compared to Its Individu…Recrutando

NCT06299683 · Pain Type and Interstitial Cystitis/Bladder Pain Syndrome Tr…Recrutando

NCT06366269 · Acupuncture First for IC/BPSRecrutando

NCT00389142 · Identifying Genetic Causes of IC/BPSRecrutando

NCT05726786 · The Role of Preoperative Immunonutrition on Morbidity and Im…Recrutando

PHASE3

NCT05149573 · Investigation of PEMF Therapy for Female Patients With IC/BP…Recrutando

NCT04734106 · Safety and Efficacy of Aloe Vera in the Management of the Sy…Recrutando

EARLY_PHASE1

NCT06096597 · Amniotic Membrane Therapy for Interstitial Cystitis/Painful …Recrutando

PHASE2, PHASE3

NCT05147779 · Safety of Cultured Allogeneic Adult Umbilical Cord Stem Cell…Recrutando

PHASE1

NCT06719232 · Evaluating the Efficacy and Patient Experience of Catheter-F…Recrutando

NCT06212661 · Migraine Medication Effects on Urinary SymptomsPor convite

Outros ensaios clínicos

217 ensaios clínicos encontrados, 22 ativos.

Distribuição por fase

NCT06752603 · A Clinical Study of ONO-1110 in Patients With Hunner Type In…Ativo

NCT02870738 · Bladder Directed vs. Pelvic Floor Therapy in IC/BPSAtivo

NCT05696444 · Medtronic Hugo™ Robotic Assisted Surgery (RAS) System in Uro…Ativo

NCT06013449 · Efficacy of Pulsed Electromagnetic Field and Heparin/Bupivac…Em breve

NCT07038512 · Evaluation of Hyivy Floora in Managing Interstitial Cystitis…Em breve

Ver todos no ClinicalTrials.gov

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Publicações mais relevantes

Timeline de publicações

1.931 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 1.931

#1

Research advances on the urinary microbiome in non-infectious urinary tract diseases: from community composition to clinical prospects.

Frontiers in cellular and infection microbiology2026

With the rapid development of 16S rRNA sequencing and metagenomic technologies, the traditional concept of sterile urine has been completely overturned, and a diverse urinary microbiome has been identified even in healthy individuals. Increasing evidence indicates that dysbiosis of the urinary microbiome is closely associated with the onset and progression of various non-infectious urological diseases. This review systematically summarizes recent advances in the role of the urinary microbiome in non-infectious urological diseases, including bladder cancer, benign prostatic hyperplasia, prostate cancer, nephrolithiasis, interstitial cystitis/bladder pain syndrome, and urinary incontinence, with a focus on microbial dysbiosis, pathogenic mechanisms, and clinical applications. Studies have shown that alterations in the composition and diversity of the urinary microbiome are closely related to chronic inflammation, immune dysregulation, metabolic disturbances, and changes in the local microenvironment. These alterations may contribute to disease pathogenesis through mechanisms such as persistent low-grade inflammation, abnormal metabolic activity, and biofilm formation. In recent years, non-invasive detection based on urinary microbial profiles has shown promising potential in the early diagnosis of bladder and prostate cancers, with some machine learning models achieving diagnostic accuracies above 80 percent. Furthermore, the urinary microbiome may influence the efficacy of immunotherapy, offering new insights for personalized precision medicine. This review summarizes the mechanisms, research status, and clinical prospects of the urinary microbiome in non-infectious urological diseases, emphasizing the importance of methodological standardization and highlighting its potential applications in early screening, diagnostic stratification, and microbiome-targeted interventions.

#2

Pigmentary Maculopathy in Patients with Interstitial Cystitis: Association with Pentosan Polysulfate and Other Therapies.

Ophthalmology science2026 Jan

To examine the association between the development of pigmentary maculopathy and exposure to pentosan polysulfate sodium (PPS) and other therapies in patients with interstitial cystitis (IC). Single-center retrospective study. Patients diagnosed with IC who had ≥2 eye examinations at Wake Forest School of Medicine between January 2011 and August 2021. Two masked retina specialists evaluated available multimodal imaging for pigmentary maculopathy using the established criteria, with any disagreements adjudicated by a third reviewer. Cases were categorized by severity and analyzed for associations with medication exposure. Association between the development of pigmentary maculopathy with PPS exposure duration and cumulative dose, and concurrent IC medication use. A total of 336 patients with IC (176 with PPS exposure, 160 without) were included. Patients with PPS exposure had increased odds of exposure to hydroxyzine (odds ratio [OR]: 4.76, P < 0.0001), amitriptyline (OR: 2.62, P < 0.0002), phenazopyridine or pyridium (OR: 1.68, P = 0.036), narcotics (OR: 2.68, P < 0.0001), oxybutynin (OR: 1.93, P = 0.041), cystoscopy with hydrodistention (OR: 4.001, P < 0.0001), bladder instillation (OR: 6.83, P < 0.0001), and vaginal valium (OR: 9.515, P = 0.033). Of the 122 patients with retinal imaging (71 with PPS exposure, 51 without), 8 patients (16 eyes) were graded to have pigmentary maculopathy and all 8 patients had PPS exposure. The median duration of PPS exposure in patients with moderate/severe maculopathy was 121 months (interquartile range [IQR] 117, 121) with a median cumulative dose of 929 200 mg (IQR 799 200; 1 109 100), which were significantly higher than patients with mild or no maculopathy (median duration 35 months [IQR 10, 63], P = 0.002 and median dose 166 800 mg [IQR 44 600; 569 100], P = 0.004). Higher proportions of patients with pigmentary maculopathy than those without had concurrent exposure to PPS and amitriptyline/nortriptyline (75% vs. 34.9%, P = 0.015) or PPS and cyclosporine (37.5% vs. 1.6%, P = 0.003). Pentosan polysulfate sodium exposure, and not IC itself, was associated with the development of pigmentary maculopathy. Longer duration and higher cumulative dose were associated with worse maculopathy. Patients on PPS were more likely to be on multiple other therapies for IC. Concurrent exposure to PPS and amitriptyline/nortriptyline or cyclosporine may increase the risk of developing maculopathy but these results should be validated by larger prospective studies. Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

#3

A meta-umbrella review of risk factors for vulvodynia: evidence from demographic, psychosocial, and biomedical domains.

The journal of sexual medicine2026 Mar 09

Vulvodynia is a chronic vulvar pain condition significantly affecting the quality of life. Its multifactorial etiology is not fully understood, and comprehensive pooled data on associated risk factors are lacking due to heterogeneous research. This umbrella review addresses this gap. This systematic umbrella review and meta-analysis aims to synthesize existing evidence on demographic, psychosocial, and biomedical risk factors associated with vulvodynia. We seek to quantitatively evaluate the strength of these associations, assess the quality of information in the current literature, and determine the clinical impact of each identified risk factor. Following Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA), we searched major databases for meta-analyses, systematic reviews, and comparative observational studies. We included potential risk factors with ≥100 vulvodynia cases. Risk of bias was assessed via Risk Of Bias In Non-randomized Studies - of Exposures (ROBINS-E); data were analyzed using the metaumbrella in R, measuring associations as equivalent odds ratios (eORs) with 95% confidence intervals. Evidence was stratified into 5 classes using 2 different approaches evaluating the strength and quality of the evidence. We identified 15 meta-analyses, 28 systematic reviews, and 129 primary studies (87 from reviews/meta-analyses and 42 from individual searches) (30 095 vulvodynia cases and 14 928 868 controls from 1993 to 2025). Convincing or very suggestive evidence of association included: fibromyalgia (eOR = 2.62, 95% CI, 2.06-3.35), recurrent urinary tract infection (eOR = 3.12, 95% CI, 2.16-4.48), recurrent vulvovaginal candidiasis (eOR = 3.07, 95% CI, 2.38-3.96), irritable bowel syndrome (eOR = 2.79, 95% CI, 2.24-3.49), anxiety (eOR = 2.7, 95% CI, 2.18-3.4), depression (eOR = 2.56, 95% CI, 1.92-3.4), systemic inflammation (eOR = 2.30, 95% CI, 1.76-3.00), and allergy/atopy (eOR = 1.83, 95% CI, 1.52-2.22). Suggestive evidence was found for interstitial cystitis (eOR = 9.11, 95% CI, 3.27-25.42), endometriosis (eOR = 5.39, 95% CI, 2.25-12.93), and younger age (eOR = 0.51, 95% CI, 0.37-0.69). Additional 23 psychosocial and biomedical factors also showed significant associations with varying degrees of evidence. Subgroup analysis for generalized/unspecific vulvodynia showed similar results with reduced heterogeneity. This meta-umbrella review identifies numerous factors strongly associated with vulvodynia, highlighting its multifactorial nature. These findings are crucial for clinical history and future research.

#4

Gender Disparities in Procedural Management of Hunner Lesion Interstitial Cystitis.

Neurourology and urodynamics2026 Mar 19

Interstitial cystitis/bladder pain syndrome (IC/BPS) is marked by chronic pelvic pain and urinary symptoms, affecting millions. Hunner-type IC (HIC), representing ~20% of cases, is characterized by distinct inflammatory pathology and worse symptom severity. Despite evidence of sex-based differences in IC/BPS, data specific to HIC remains sparse. This study examined sex differences in clinical presentation, management, and outcomes in HIC patients. Single-center retrospective analysis of 114 patients with confirmed HIC managed between 2011 and 2024. We assessed sex-based differences across clinical presentation, diagnostic timelines, treatments, and quality of life. Cox proportional hazards models identified predictors of repeat fulguration and cystectomy. Among 114 patients (68% female with median age of 68 years) females reported more anxiety (33.3% vs. 13.9%, OR 3.13, p = 0.04), recurrent/multidrug-resistant UTIs (p < 0.001, OR 8.37,p = 0.02), and pelvic pain (55.1% vs. 30.6%, OR 2.50, p = 0.02), longer wait times to biopsy 2.94 versus 0.77 months, p = 0.026), and underwent more bladder instillations (32.9% vs. 11.8%, OR 3.57 p = 0.02). Males more frequently reported nocturia (33.3% vs. 12.8%, OR 3.4, p = 0.02). In multivariate analysis, male sex (HR 3.69, p = 0.006), greater Hunner lesion burden on first cystoscopy (HR 1.35, p = 0.035), and absence of pelvic pain (HR 0.33, p = 0.031) independently predicted repeat fulguration; protection was associated with anticholinergic/beta-agonist use (HR 0.14, p = 0.003). Cystectomy was predicted by MDR-UTI (p < 0.001), narcotic use (p = 0.009), neuromodulation history (p = 0.016), recurrent UTIs (p = 0.031), and hematuria (p = 0.004), independent of sex. Sex-based differences in HIC presentation and management exist despite comparable disease severity, with females showing higher symptom burden and male sex predicting repeat fulguration. Cystectomy progression was driven by clinical severity markers rather than sex. These findings support the need for sex-stratified diagnostic and treatment algorithms and prospective validation studies.

#5

Emerging Urinary Biomarkers for Diagnosis, Phenotyping, and Treatment Monitoring in Female Overactive Bladder: A Systematic Review.

International urogynecology journal2026 Mar 17

Overactive bladder (OAB) syndrome, characterised by urinary urgency, frequency, and nocturia can significantly impacts patients' quality of life. Current diagnosis is clinical, but complex cases often require invasive urodynamic studies (UDS), which are costly, subjective, and carry risks like discomfort and infection. Therefore, we hypothesise that urinary biomarkers could serve as noninvasive diagnostic tools for OAB. Establishing a reliable biomarker profile could ultimately lessen the reliance on invasive US, provided clinical validity is confirmed. Following PRISMA guidelines and registered under PROSPERO (ID: CRD420251026279), a comprehensive search across six major databases was conducted from their inception until September 2025, yielding 39 studies for qualitative analysis. This qualitative review identified several promising biomarkers for OAB diagnosis. Notably, NGF and BDNF consistently emerged as elevated in OAB patients and were responsive to treatment. Additionally, TNF-α, MIP-1β, Tie2, and CCL2 showed diagnostic potential, with TNF-α and MIP-1β particularly useful for differentiating OAB from interstitial cystitis/bladder pain syndrome (IC/BPS) and urinary tract infections (UTIs). However, limitations such as variability in measurement protocols and a lack of specificity for certain biomarkers (e.g. MMP-1, 8-OHdG) were noted. Urinary biomarkers offer a promising noninvasive approach to diagnosing OAB. Further validation of promising markers, particularly NGF, BDNF, TNF-α, MIP-1β, and CCL2, could lead to individualised therapies. While promising, the routine replacement of UDS remains an aspirational goal dependent on future large-scale validation.

Publicações recentes

Hyaluronic Acid Increase Anti-Inflammatory and Regenerative Effects of Adipose-Derived Mesenchymal Stem Cells in an Interstitial Cystitis Rat Model.

Appl Biochem Biotechnol2026 Apr 16

Retrospective study of visual acuity changes in patients with interstitial cystitis receiving pentosan polysulfate sodium.

Curr Med Res Opin2026 Apr 16

Normalization of Magnesium Deficiency with Magnesium-L-Threonate Alleviates Bladder Overactivity in Cyclophosphamide-Induced Cystitis: Mechanisms of Inflammatory Modulation and Barrier Restoration.

Eur J Pharmacol2026 Apr 13

[Update of the S2k guideline on the diagnosis and treatment of interstitial cystitis/bladder pain syndrome (IC/BPS)].

Urologie2026 Apr 13

Retinal Pigment Epithelium Injury in Pentosan Polysulfate Exposure: Morphologic Changes, Phagocytic Deficits, and Mitochondrial Dysfunction.

bioRxiv2026 Mar 31

Ver todas no PubMed

📚 EuropePMC2.896 artigos no totalmostrando 195

The journal of sexual medicine

A meta-umbrella review of risk factors for vulvodynia: evidence from demographic, psychosocial, and biomedical domains.

Gender Disparities in Procedural Management of Hunner Lesion Interstitial Cystitis.

Frontiers in cellular and infection microbiology

Research advances on the urinary microbiome in non-infectious urinary tract diseases: from community composition to clinical prospects.

Emerging Urinary Biomarkers for Diagnosis, Phenotyping, and Treatment Monitoring in Female Overactive Bladder: A Systematic Review.

Lower urinary tract symptoms

Treatment-Specific Clinical and Urinary Biomarker Signatures Associated With Response to Intravesical Botulinum Toxin A and Platelet-Rich Plasma in Bladder Pain Syndrome.

Lower urinary tract symptoms

A Survey on Real-World Transurethral Surgery Procedures for Bladder Pain Syndrome and Interstitial Cystitis.

Metabotropic glutamate receptor 5 expression associates with pain and inflammatory pathways in interstitial cystitis.

International immunopharmacology

Naringenin inhibits Ferroptosis and ameliorates interstitial cystitis with metabolic syndrome by activating the Nrf2/NQO-1 pathway.

The microbiome of interstitial cystitis revealed by 2bRAD-M.

miRNA expression profile as a potential tool for discrimination between bacterial and interstitial cystitis.

Frontiers in immunology

International journal of women's health

Cystoscopic Hydrodistension Under Local Anesthesia: Therapeutic Implications in Non-Hunner IC Subtypes.

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

[The Protective Function of TRPV4 in Interstitial Cystitis/Bladder Pain Syndrome].

Adjuvant bladder thermal irrigation for ultrasound-guided botulinum toxin a injection in refractory bladder pain syndrome: a retrospective cohort study.

Protective potential of linalool against cyclophosphamide-induced interstitial cystitis: mechanistic insights from experimental and computational approaches.

Journal of veterinary internal medicine

Low-dose radiation therapy for idiopathic or interstitial cystitis in male cats.

External validation of combining clinical parameters and urinary biomarker clusters and development of a nomogram for identifying bladder-centric interstitial cystitis/bladder pain syndrome in patients with lower urinary tract symptoms.

Interstitial cystitis: a phenotype and rare variant exome sequencing study.

EBioMedicine

Investigation of the hematological parameters in women with Interstitial Cystitis/Bladder Pain Syndrome and their relationship with disease severity.

Role of patch cystoplasty in intractable interstitial cystitis/bladder pain syndrome.

Urology annals

Enhanced CHI3L1 promotes macrophage activation in persistent inflammatory events of ulcerative interstitial cystitis.

Frontiers in immunology

Journal of minimally invasive gynecology

Impact of a Patient-Centered Chronic Pelvic Pain Toolkit on Patient Satisfaction: A Randomized Control Pilot Study.

A simplified algorithm for management of CP/CPPS and associated entities: A summary table for general urologists.

Current urology

Pentosan Polysulfate and Heparin Exhibit Comparable Interactions with Platelet Factor 4, Suggesting a Potential Risk of Thrombocytopenia.

ACS omega

A prospective, multicenter, real-world effectiveness and safety study of high molecular weight sodium hyaluronate for interstitial cystitis/bladder pain syndrome.

Interstitial cystitis-related gene CCDC8 accelerates tumorigenesis by participating in CUL7-mediated degradation of P53 in bladder cancer.

Oncogene

Progression of Presumed Pentosan Polysulfate Sodium Maculopathy After Drug Cessation.

JAMA ophthalmology

Inhibition of bladder sensory afferents via intrabladder injection of adenoassociated viruses-retro-mediated Gi-DREADDs alleviates bladder overactivity and pain in mice.

Pain

TOP2A drives T-cell infiltration and immune remodeling in cyclophosphamide-induced cystitis: a single-cell sequencing study with potential implications for interstitial cystitis.

Shared Decision-making in Urology: The SHINE-URO Consensus Framework.

European urology focus

Using intravesical botulinum toxin as an adjunct during urologic surgery: a systematic review.

World journal of urology

A Review of NIDDK-Funded Studies of Urological Chronic Pain Conditions.

Frontiers in cardiovascular medicine

Case Report: Neuropsychiatric improvement after treatment of pelvic venous disorder in a multisyndromic patient.

Advances in Cytokines and Inflammatory Mechanisms in the Pathogenesis of Interstitial Cystitis/Bladder Pain Syndrome.

Biomolecules

Advanced healthcare materials

In Situ Synthesis of Glycosaminoglycan-Mimicking Coatings Driven by Local Pathological Microenvironment: Boosting Bladder Mucosal Regeneration and Barrier Function.

Impact of Elmiron adjunct therapy on outcomes of fulguration in chronic interstitial cystitis in women.

Transitions from Regional to Widespread Pain in Urologic Chronic Pelvic Pain Syndrome: A Multidisciplinary Approach to the Study of Chronic Pelvic Pain II Research Network Study.

The Journal of urology

Indian journal of urology : IJU : journal of the Urological Society of India

Associations of pain in young men presenting with lower urinary tract symptoms.

COVID-19-Associated Cystitis: De Novo Urinary Urgency Following SARS-CoV-2.

Cureus

Functional bladder capacity can reflect the bladder condition and treatment outcome in patients with interstitial cystitis/bladder pain syndrome.

World journal of urology

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

Lamina Propria Collagen Architecture in Interstitial Cystitis/Bladder Pain Syndrome.

International journal of molecular sciences

Pilot Proteomic Analysis of Urinary Extracellular Vesicles Supports the "Toxic Urine Hypothesis" as a Vicious Cycle in Refractory IC/BPS Pathogenesis.

Efficacy and safety of low-intensity shockwave therapy on lower urinary tract symptoms in non-prostatic condition: A systematic review and meta-analysis.

Arab journal of urology

The world journal of men's health

Intravesical Cannabidiol for Inflammation and Pain in Interstitial Cystitis/Bladder Pain Syndrome via TLR4/NF-κB and TRPV1 Modulation.

bioRxiv : the preprint server for biology

Urobiome Analysis in Interstitial Cystitis/Bladder Pain Syndrome Reveals Nuanced Differences Associated with Localized Pain.

Annals of medicine and surgery (2012)

Post-COVID-19 interstitial cystitis and bladder dysfunction: a growing concern for public health.

Pain research & management

Pudendal Nerve Pulsed Radiofrequency Effectively Alleviates Perineal Pain in Interstitial Cystitis/Bladder Pain Syndrome: A Retrospective Study.

American journal of ophthalmology case reports

Severe bilateral retinal degeneration following a twenty-six-year pentosan polysulfate sodium exposure: a case report.

Clinical and experimental medicine

Inflammation-associated immune-related genes as potential biomarkers for the diagnosis of interstitial cystitis.

Therapeutic efficacy of multimodal therapy for patients with interstitial cystitis/bladder pain syndrome refractory to previous bladder monotherapy.

Bladder tumors in patients initially diagnosed with interstitial cystitis: a ten-year retrospective study.

Exploring the molecular link between obstructive sleep apnea and interstitial cystitis/bladder pain syndrome: A bioinformatics and machine learning study.

Efficacy and safety of pentosan polysulfate therapy in patients with interstitial cystitis for relief of lower urinary tract symptoms: 15-year single center experience.

Prostate international

Multi-omics analysis identifies a microbiota-bile acid-TLR signaling axis driving bladder injury in interstitial cystitis.

Nature communications

Uncovering the molecular mechanism of solasonine in treating interstitial cystitis via network pharmacology and molecular docking.

Comparing benign to malignant cystectomy: complications, emergency department utilization, readmissions, and socioeconomic status.

Behaviour research and therapy

Role of psychosocial factors of symptom flares in a cohort of patients with urologic chronic pelvic pain syndrome: A cognitive-affective approach.

Molecular therapy. Nucleic acids

HLA-DQB1-mediated B cell-epithelial crosstalk drives EBV-associated inflammation in Hunner-type interstitial cystitis.

Frontiers in molecular medicine

Association of specific HLA alleles in patients with interstitial cystitis suggesting autoimmunity.

Urogynecology (Philadelphia, Pa.)

Providing Clarification on the Use of Interstitial Cystitis/Bladder Pain Syndrome.

Using structural equation modelling to explore the relationship between insomnia, anxiety and depression to the severity of BPS/IC: a cross-sectional study in Chongqing, China.

BMJ open

Advanced pharmaceutical bulletin

Platelet-Rich Plasma in Interstitial Cystitis/Bladder Pain Syndrome: A Systematic Review and Meta-Analysis.

Low-energy extracorporeal shock-wave therapy with or without intravesical botulinum toxin A instillations for refractory interstitial cystitis/bladder pain syndrome: a randomized double-blind trial of clinical and biomarker outcomes.

Neuromodulation : journal of the International Neuromodulation Society

Sacral Nerve Stimulation and Chronic Bladder Pain: Meta-Analysis.

How Can We Make Progress in the Management of Bladder Pain Syndrome? ICI-RS 2025.

Urologic chronic pelvic pain syndrome 3-year symptom trajectories: the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Symptom Patterns Study.

BJU international

European urology open science

Integrative Diagnostic Model Combining Urinary Biomarkers and Clinical Parameters to Improve Diagnostic Performance in Interstitial Cystitis/Bladder Pain Syndrome.

Optimal Duration of Hydrodistension for Symptomatic Treatment of Interstitial Cystitis: A Systematic Review.

Discrete mathematical network analysis bridging clinical vocabulary and patient discourse in interstitial cystitis/bladder pain syndrome online communications.

Clinical Features and Prognostic Significance of Pelvic-Perineal Pain in Women with Bladder Pain Syndrome/Interstitial Cystitis: A Retrospective Study.

Baicalin ameliorates interstitial cystitis/bladder pain syndrome by inhibiting the TLR4/NF-κB pathway.

Bladder Trigone as a Sensory Hub: A Narrative Review.

Cureus

Imaging Mass Cytometry Immune Profiling of Hunner Lesions in a Convenience Sample of Patients With Interstitial Cystitis/Bladder Pain Syndrome.

The Journal of urology

Analysis of the diagnostic value of peripheral blood immune inflammatory indicators of female bladder pain syndrome.

Frontiers in surgery

Ecotoxicology and environmental safety

Revealing the toxicity mechanisms and potential targets of PM2.5-induced different types of cystitis based on Mendelian randomization and network toxicology.

Healthcare (Basel, Switzerland)

Digital Health Technologies in the Treatment of Chronic Pelvic Pain Syndromes: A Systematic Review of Randomized Clinical Trials.

Nerve growth factor-targeting nanocluster-antibody-drug conjugates for intravesical precision theranostics of interstitial cystitis.

Biomaterials

Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia

Effects of intravesical cocktail instillation on outcomes and serum pain factors of patients with bladder pain syndrome.

American journal of clinical dermatology

Efficacy and Safety of Dupilumab in Adults with Prurigo Nodularis with or Without Atopic Comorbidities: A Subgroup Analysis from Two Randomized Phase III Clinical Trials.

Taiwanese journal of obstetrics & gynecology

The use of intravesical hyaluronic acid for the treatment of refractory interstitial cystitis/bladder pain syndrome in Taiwan: A review of the literature.

Coexistence of Pelvic Pain, Bladder, and Bowel Symptoms in Women with Pelvic Organ Prolapse: The Effect of Transvaginal Surgery.

Western journal of nursing research

Living With Interstitial Cystitis: A Qualitative Study of Women's Experiences.

Validation of the Italian Version of the O'Leary-Sant Questionnaire for Patients with Bladder Pain Syndrome/Interstitial Cystitis.

Drug-releasing intravesical floating technology for sequential gemcitabine and docetaxel in non-muscle-invasive bladder cancer.

BJU international

Molecular characterization of chronic inflammatory diseases of the urinary bladder based on next-generation RNA sequencing and digital image analysis.

Intravesical Instillation with Vivo-Morpholino Nerve Growth Factor Antisense Therapy Ameliorates Acute Interstitial Cystitis/Painful Bladder Syndrome-Related Urinary Frequency in a Rat Model.

Re: "Regulation of Autophagy by the Cdk1/p53/p21 Feedback Loop in an Interstitial Cystitis/Bladder Pain Syndrome Cell Model: Implications for Inflammatory Response".

Correlates of Positive Response to Therapeutic Hydrodistension in Interstitial Cystitis/Bladder Pain Syndrome.

British journal of nursing (Mark Allen Publishing)

The role of clinical nurse specialists in the management of patients with bladder pain syndrome.

Quality of patient information on interstitial cystitis from artificial intelligence chatbots.

BJU international

International neurourology journal

The Role of Urinary Secretory Immunoglobulin A in the Pathophysiology of Interstitial Cystitis.

International neurourology journal

Treatment Outcomes of Patients With Hunner Interstitial Cystitis Who Received Augmentation Enterocystoplasty or Bladder-Preserving Therapy.

The journal of sexual medicine

When healing isn't recovery: Perspective on "Psychosexological correlates of 372 women with vulvodynia, overactive pelvic floor, postcoital cystitis, and interstitial cystitis".

Efficacy and Safety of Submucosal Intravesical Injection of Platelet-Rich Plasma in the Treatment of Interstitial Cystitis/Painful Bladder Syndrome.

The journal of sexual medicine

Framing the overlooked: Perspective on "Psychosexological correlates of 372 women with vulvodynia, overactive pelvic floor, postcoital cystitis, and interstitial cystitis".

Pigmentary Maculopathy in Patients with Interstitial Cystitis: Association with Pentosan Polysulfate and Other Therapies.

Ophthalmology science

Frontiers in pain research (Lausanne, Switzerland)

Unstimulated inflammatory activity is associated with treatment response to cognitive-behavioral therapy for urologic chronic pelvic pain.

Urogynecology (Philadelphia, Pa.)

Phenotype Variability in Interstitial Cystitis Clinical Trial Recruitment.

Sex Differences in Cystoscopic Findings Among Veterans With Interstitial Cystitis.

Key role of KRT6A in interstitial cystitis: Machine learning-identified feature genes for bladder pain, immunity and fibrosis.

Chinese medical journal

European journal of pharmacology

TGF-β1 mediates epithelial-mesenchymal transition in interstitial cystitis through the regulation of ROCK.

The French journal of urology

BPS symptom load during pentosane polysulfate sodium treatment in real life in France.

Progress in retinal and eye research

Pentosan polysulfate maculopathy: clinical considerations, pathobiology, and causality.

International journal of urology : official journal of the Japanese Urological Association

Long-Term Clinical Outcomes of Transurethral Resection of Hunner Lesions Combined With Bladder Hydrodistension for Patients With Interstitial Cystitis at a Tertiary Referral Center in Japan.

Mini reviews in medicinal chemistry

An Overview of the Association of the Urinary Tract Microbiome with Various Diseases and Implications for Therapeutics.

Urologiia (Moscow, Russia : 1999)

[Pain syndrome in urology: features of classification and pathogenetic aspects].

Exploring promising biomarkers based on pathogenic mechanisms in interstitial cystitis/bladder pain syndrome.

Nature reviews. Urology

Systemic ozone therapy improves the quality of life in patients with bladder pain syndrome.

[ניתוחים להטיית מערכת השתן עם או ללא כריתת שלפוחית השתן בהוריה של מחלה לא ממאירה: ניסיון רב שנים של מרכז שלישוני].

Harefuah

The Role of Biomarkers in the Diagnosis and Treatment of Interstitial Cystitis/Bladder Pain Syndrome: What Does Current Evidence Reveal?

Minerva urology and nephrology

The efficacy and safety of intravesical platelet-rich plasma injections into the bladder for the treatment of interstitial cystitis/bladder pain syndrome: a systematic review and meta-analysis.

Metachronous Bilateral Nephrectomy, Supratrigonal Cystectomy, and Living Donor Renal Transplantation in a Patient With Chronic Kidney Disease due to Interstitial Cystitis and Total Urethral Stricture.

Case reports in medicine

Journal of biomedical materials research. Part A

Therapeutic Effect of a Composite Acellular Matrix/Hyaluronic Acid Thermosensitive Hydrogel for the Interstitial Cystitis/Bladder Pain Syndrome in a Rat Model.

Journal of inflammation research

NRF2 Deficiency in Bladder Epithelial Cells Owing to Ubiquitination by N6-Methyladenosine-Modified TRIM21 Induces Oxidative Stress and Inflammation to Aggravate IC/BPS.

The Journal of clinical investigation

Microbiota in interstitial cystitis/bladder pain syndrome: evidence and opportunities.

Characterization of actions of the novel gabapentinoid drug mirogabalin on painful bladder hypersensitivity in rats with lipopolysaccharide-induced chronic cystitis.

Life sciences

Journal of clinical medicine

Application of Platelet-Rich Plasma in Gynaecologic Disorders: A Scoping Review.

Journal of materials chemistry. B

Enhanced therapeutic efficacy of cationic liposome-delivered nerve growth factor antisense oligonucleotide for interstitial cystitis/bladder pain syndrome.

Stem cell research & therapy

Conditional immortalization of mesenchymal stem cells and their extracellular vesicles therapy for interstitial cystitis/bladder pain syndrome.

Seminars in reproductive medicine

More than the Lesion: Unraveling the Complexities of Endometriosis-Associated Pain.

Application study of pressure- and volume-controllable balloon in direct visualisation interstitial cystitis dilation surgery.

Journal of clinical medicine

Prevalence and Phenotype of Lower Urinary Tract Symptoms in Fibromyalgia: A Retrospective Observational Study at a Single Tertiary Medical Center.

Molecular Mechanisms and Pathways in Visceral Pain.

Cells

Frontiers in pharmacology

Colopathy associated with pentosan polysulfate use.

Current reviews in musculoskeletal medicine

Regeneration or Risk? A Narrative Review of BPC-157 for Musculoskeletal Healing.

Global Consensus on Interstitial Cystitis/Bladder Pain Syndrome: An Update on Therapeutic Treatments.

Integrated identification of immune-related therapeutic targets for interstitial cystitis via multi-algorithm machine learning: transcriptomic profiling and in vivo experimental validation.

Frontiers in immunology

Development of Novel Intravesical Formulation for Bladder Retention Targeting Bladder Disorders.

Current drug targets

Intravesical substance P enhances bladder afferent nerve activity without the influence of the micturition reflex.

New insights into interstitial cystitis/bladder pain syndrome at single-cell resolution.

BJUI compass

Variability in the Diagnosis and Treatment of Interstitial Cystitis/Bladder Pain Syndrome: Internet Survey.

JMIR formative research

The Posterior Fornix Syndrome Is an Important Differential Diagnosis for Interstitial Cystitis/Bladder Pain Syndrome.

Urologia internationalis

Artificial intelligence for diagnosing bladder pathophysiology: An updated review and future prospects.

Pentosan polysulfate alleviates interstitial cystitis/bladder pain syndrome by modulating bile acid metabolism and activating the TGR5 receptor through gut microbiota regulation.

A standardized protocol for modified platelet-rich plasma collection for the treatment of interstitial cystitis/bladder pain syndrome.

Journal of health psychology

"I can't enjoy my full sex life": Understanding the sexual experiences of women with interstitial cystitis.

Retinal cases & brief reports

Rapid progression of maculopathy after Pentosan Polysulfate Sodium cessation.

Multi-omics profiling reveals distinct pathogenic mechanisms in Hunner and non-Hunner interstitial cystitis subtypes.

Mast Cells and Interstitial Cystitis/Bladder Pain Syndrome Revisited.

Magnetically controlled microgelbots with stem cells for the treatment of interstitial cystitis.

Biomaterials

Long-term functional outcomes and complications of robot-assisted laparoscopic supratrigonal cystectomy with augmentation cystoplasty in adult patients with neurogenic lower urinary tract dysfunction and interstitial cystitis/bladder pain syndrome: A single-centre experience.

BJUI compass

Genomics and Histopathology in Interstitial Cystitis/Bladder Pain Syndrome.

BMC complementary medicine and therapies

Navigating the decision landscape: understanding interstitial cystitis/bladder pain syndrome patients' motivations and medical support needs for fecal microbiota transplantation: a qualitative research.

An Analysis of the Accuracy, Quality, and Readability of Online Health Information for Interstitial Cystitis/Bladder Pain Syndrome.

Urology

Association of HRQOL With Symptom Patterns in an Online Cohort of Patients With Interstitial Cystitis/Bladder Pain Syndrome.

Urology

Neuromodulation : journal of the International Neuromodulation Society

Nonimplantable Peripheral Electrical Stimulation for Management of Chronic Pelvic Pain: An Umbrella Review.

Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) Diagnosis: Current Limitations and a Pragmatic Clinical Diagnostic Definition.

Patient Related Outcomes for Interstitial Cystitis/Bladder Pain Syndrome Recommendations for Clinical Trials and General Urology Practice.

Interstitial Cystitis/Bladder Pain Syndrome: Why a Global Patient Registry Is Critically Needed.

A Case of Interstitial Cystitis With Hunner Lesions Involving Bilateral Ureters.

IJU case reports

Interstitial Cystitis/Bladder Pain Syndrome in Men.

A Review of the Etiopathology of Phenotypes in Interstitial Cystitis/Bladder Pain Syndrome.

Nan fang yi ke da xue xue bao = Journal of Southern Medical University

[Pentosan polysulfate alleviates cyclophosphamide-induced interstitial cystitis/bladder pain syndrome in mice by modulating gut microbiota and bile acid metabolism].

Role of Gynecologic Findings in Interstitial Cystitis/Bladder Pain Syndrome: A Consensus.

Journal of innate immunity

Oxidative Stress and Chronic Inflammation as Partners in Crime in Interstitial Cystitis/Bladder Pain Syndrome.

Comparative Risk of Developing Interstitial Cystitis With Childhood Gastrointestinal, Urological, Autoimmune, or Psychiatric Disorders.

Interstitial Cystitis/Bladder Pain Syndrome Patient Phenotyping.

Life (Basel, Switzerland)

Bladder p75NTR-Mediated Anti-Inflammatory Response via the TLR4/TRAF6/NF-κB Axis.

International journal of molecular sciences

Pterostilbene Reduces Cyclophosphamide-Induced Interstitial Cystitis by Facilitating Nrf2 Activation and Suppressing the NLRP3 Inflammasome Pathway.

Addressing Commonly Asked Questions in Urogynecology: Accuracy and Limitations of ChatGPT.

Healthcare (Basel, Switzerland)

Exploring the Efficacy of Vessilen® in Treating Bladder Pain Syndrome/Interstitial Cystitis: A Prospective Study.

Journal of clinical medicine

Long-Term Outcomes of Sacral Neuromodulation for Refractory Interstitial Cystitis/Bladder Pain Syndrome: A Retrospective Cohort Study.

Journal of inflammation research

Identification and Validation of Oxidative Stress-Related Diagnostic Marker Genes and Immune Landscape in Ulcerative Interstitial Cystitis by Integrating Bioinformatics and Machine Learning.

Urologic Chronic Pelvic Pain Syndrome: A Scoping Review of Syndrome-Specific Instruments.

Carry-over effects in GAG therapy efficacy trial solution for bladder pain syndrome/interstitial cystitis (GETSBI study): an interim analysis.

BMJ open

The role of netrin-1 in the diagnosis and prognosis of bladder pain syndrome /interstitial cystitis: a comparative study.

World journal of urology

Regulation of Autophagy by the Cdk1/p53/p21 Feedback Loop in an Interstitial Cystitis/Bladder Pain Syndrome Cell Model: Implications for Inflammatory Response.

Self-Efficacy in Managing Female Sexual Dysfunction in Interstitial Cystitis.

Urology

Characteristic genes and immune landscape of interstitial cystitis.

Variability in Health Care Utilization and Perioperative Outcomes Among Urinary Diversion Patients: Analysis of the National Surgical Quality Improvement Program Database.

Urology practice

Widespread Pain Moderates the Response to Centrally-Acting Therapies in an Observational Cohort of Patients With Urologic Chronic Pelvic Pain Syndrome: A MAPP Research Network Study.

Chronic Pain Syndromes in Women.

Primary care

Journal of neural transmission (Vienna, Austria : 1996)

MeDeMSA care study protocol: developing personalized best medical care with integrated mobile palliative and telemedicine support for individuals with multiple system atrophy.

Inhibition of HPSE/SDC-2 axis-induced epithelial-mesenchymal transition for treating IC/BPS.

Annals of surgical oncology

Perioperative Complications and In-hospital Mortality After Cystectomy for Nonbladder Cancer Conditions Versus Radical Cystectomy for Bladder Cancer.

Intravesical injection of peripheral blood mononuclear cell for the treatment of interstitial cystitis: A preliminary report.

Journal of trauma & dissociation : the official journal of the International Society for the Study of Dissociation (ISSD)

Military Sexual Trauma's Association with Lower Urinary Tract Symptoms (LUTS) and Fecal Incontinence (FI) Among U.S. Female Veterans.

Stem cells translational medicine

A single-center, phase 1/2a trial of hESC-derived mesenchymal stem cells (MR-MC-01) for safety and efficacy in interstitial cystitis patients.

Resilience among adults with chronic urologic pelvic pain syndrome: A flexible self-regulation perspective.

The journal of pain

Pathophysiology and potential multimodal therapeutic strategies for IC/BPS.

Nature reviews. Urology

S100A9 as a potential novel target for experimental autoimmune cystitis and interstitial cystitis/bladder pain syndrome.

Biomarker research

Molecular medicine reports

The corticotropin‑releasing factor family in the urogenital system (Review).

Evaluation of clinical efficacy of pelvic ultrasound monitoring combined with scale scoring in the treatment of interstitial cystitis by intravesical instillation regimen combined with hydrodistention and transurethral fulguration.

Association of Bladder Pain Syndrome/Interstitial Cystitis with Hyperlipidemia: A Case‒Control Study.

International journal of molecular sciences

Applying K-Means Cluster Analysis to Urinary Biomarkers in Interstitial Cystitis/Bladder Pain Syndrome: A New Perspective on Disease Classification.

Long-Term Antibiotics for Disturbed Bladder Microbiome Disorders.

Novel Application of T1ρ Magnetic Resonance Imaging for Noninvasive Assessment of Bladder Hyperpermeability Biomarkers: A Focus on Glycosaminoglycan Content.

International journal of biological macromolecules

Chondroitin sulfate: From bioactive molecule to versatile drug delivery system for advancing regenerative medicine.

Expert review of molecular diagnostics

The integration of biomarkers and patient-reported outcomes improves prediction of interstitial cystitis syndrome.

Research Methodology in Acupuncture for Managing Interstitial Cystitis/Bladder Pain Syndrome: A Scoping Review.

Journal of biomedical optics

In situ observation of urothelial responses to NaCl-induced osmotic stress using optical coherence tomography.

Women's health reports (New Rochelle, N.Y.)

Establishing Evidence for the Painful Intercourse Self-Efficacy Scale-Interstitial Cystitis.

Towards precision medicine in clinical trials for the treatment of urologic chronic pelvic pain syndrome: lessons from the MAPP Research Network.

Nature reviews. Urology

Frontiers in pharmacology

Safety and efficacy of intravesical instillation of botulinum toxin-A in the treatment of interstitial cystitis/bladder pain syndrome and overactive bladder: a systematic review and meta-analysis.

Hypoparathyroidism is associated with bladder dysfunction, a preliminary study.

Ver todos os 2.896 no EuropePMC

Interleukins in Urological Diseases.

Discovery medicine

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