Raras
Buscar doenças, sintomas, genes...
Bloqueio cardíaco congênito
ORPHA:60041CID-10 · Q24.6CID-11 · LA8YOMIM 234700DOENÇA RARA

Bloqueio cardíaco que ocorre antes dos 28 dias de vida.

Mantido por Agente Raras·Colaborar como especialista →

Introdução

O que você precisa saber de cara

📋

Bloqueio cardíaco que ocorre antes dos 28 dias de vida.

Publicações científicas
955 artigos
Último publicado: 2026 Feb

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
Unknown
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Worldwide
Início
Infancy
+ neonatal
🏥
SUS: Cobertura mínimaScore: 35%
Centros em: MG, PR, SC, RS, ES +10CID-10: Q24.6
🇧🇷Dados SUS / DATASUS
PROCEDIMENTOS SIGTAP (5)
0202010503
Cariótipo — bandas G, Q ou Rgenetic_test
0202010600
Pesquisa de microdeleções/microduplicações por FISHlab_test
0202010694
Sequenciamento completo do exoma (WES)rehabilitation
0202010260
Dosagem de alfa-fetoproteína
0301070040
Atendimento em reabilitação — doenças raras
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Entender a doença

Do básico ao detalhe, leia no seu ritmo

Preparando trilha educativa...

Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

❤️
Coração
15 sintomas
📏
Crescimento
2 sintomas

+ 19 sintomas em outras categorias

Características mais comuns

100%prev.
Bloqueio atrioventricular
90%prev.
Bloqueio atrioventricular de terceiro grau
Muito frequente (99-80%)
55%prev.
Parto vaginal após cesariana
Frequente (79-30%)
55%prev.
Nascimento prematuro
Frequente (79-30%)
17%prev.
Intervalo QTc prolongado
Ocasional (29-5%)
17%prev.
Cianose
Ocasional (29-5%)
36sintomas
Muito frequente (2)
Frequente (2)
Ocasional (21)
Muito raro (4)
Sem dados (7)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 36 características clínicas mais associadas, ordenadas por frequência.

Bloqueio atrioventricularAtrioventricular block
Muito frequente100%
Bloqueio atrioventricular de terceiro grauThird degree atrioventricular block
Muito frequente (99-80%)90%
Parto vaginal após cesarianaVaginal birth after Caesarian
Frequente (79-30%)55%
Nascimento prematuroPremature birth
Frequente (79-30%)55%
Intervalo QTc prolongadoProlonged QTc interval
Ocasional (29-5%)17%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico955PubMed
Últimos 10 anos200publicações
Pico202036 papers
Linha do tempo
2026Hoje · 2026🧪 1984Primeiro ensaio clínico📈 2020Ano de pico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
2Fase 21
1Fase 11
·Pré-clínico5
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 7 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Bloqueio cardíaco congênito

Centros de Referência SUS

24 centros habilitados pelo SUS para Bloqueio cardíaco congênito

Centros para Bloqueio cardíaco congênito

Detalhes dos centros

Hospital Universitário Prof. Edgard Santos (HUPES)

R. Dr. Augusto Viana, s/n - Canela, Salvador - BA, 40110-060 · CNES 0003808

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do Metabolismo

Hospital Infantil Albert Sabin

R. Tertuliano Sales, 544 - Vila União, Fortaleza - CE, 60410-794 · CNES 2407876

Serviço de Referência

Rota
Anomalias CongênitasDeficiência Intelectual

Hospital de Apoio de Brasília (HAB)

AENW 3 Lote A Setor Noroeste - Plano Piloto, Brasília - DF, 70684-831 · CNES 0010456

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do MetabolismoDeficiência Intelectual

Hospital Estadual Infantil e Maternidade Alzir Bernardino Alves (HIABA)

Av. Min. Salgado Filho, 918 - Soteco, Vila Velha - ES, 29106-010 · CNES 6631207

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do MetabolismoDeficiência Intelectual

Hospital das Clínicas da UFG

Rua 235 QD. 68 Lote Área, Nº 285, s/nº - Setor Leste Universitário, Goiânia - GO, 74605-050 · CNES 2338424

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do Metabolismo

Hospital Universitário da UFJF

R. Catulo Breviglieri, Bairro - s/n - Santa Catarina, Juiz de Fora - MG, 36036-110 · CNES 2297442

Atenção Especializada

Rota
Anomalias Congênitas

Hospital das Clínicas da UFMG

Av. Prof. Alfredo Balena, 110 - Santa Efigênia, Belo Horizonte - MG, 30130-100 · CNES 2280167

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do MetabolismoDeficiência Intelectual

Hospital Universitário Julio Müller (HUJM)

R. Luis Philippe Pereira Leite, s/n - Alvorada, Cuiabá - MT, 78048-902 · CNES 2726092

Atenção Especializada

Rota
Anomalias Congênitas

Hospital Universitário João de Barros Barreto

R. dos Mundurucus, 4487 - Guamá, Belém - PA, 66073-000 · CNES 2337878

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do MetabolismoDeficiência Intelectual

Hospital Universitário Lauro Wanderley (HULW)

R. Tabeliao Estanislau Eloy, 585 - Castelo Branco, João Pessoa - PB, 58050-585 · CNES 0002470

Atenção Especializada

Rota
Anomalias Congênitas

Instituto de Medicina Integral Prof. Fernando Figueira (IMIP)

R. dos Coelhos, 300 - Boa Vista, Recife - PE, 50070-902 · CNES 0000647

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do MetabolismoDeficiência Intelectual

Hospital Pequeno Príncipe

R. Des. Motta, 1070 - Água Verde, Curitiba - PR, 80250-060 · CNES 3143805

Serviço de Referência

Rota
Anomalias CongênitasDeficiência Intelectual

Hospital Universitário Regional de Maringá (HUM)

Av. Mandacaru, 1590 - Parque das Laranjeiras, Maringá - PR, 87083-240 · CNES 2216108

Atenção Especializada

Rota
Anomalias Congênitas

Hospital de Clínicas da UFPR

R. Gen. Carneiro, 181 - Alto da Glória, Curitiba - PR, 80060-900 · CNES 2364980

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do MetabolismoDeficiência Intelectual

Hospital Universitário Pedro Ernesto (HUPE-UERJ)

Blvd. 28 de Setembro, 77 - Vila Isabel, Rio de Janeiro - RJ, 20551-030 · CNES 2280221

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do Metabolismo

Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira (IFF/Fiocruz)

Av. Rui Barbosa, 716 - Flamengo, Rio de Janeiro - RJ, 22250-020 · CNES 2269988

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do MetabolismoDeficiência Intelectual

Hospital São Lucas da PUCRS

Av. Ipiranga, 6690 - Jardim Botânico, Porto Alegre - RS, 90610-000 · CNES 2232928

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do Metabolismo

Hospital de Clínicas de Porto Alegre (HCPA)

Rua Ramiro Barcelos, 2350 Bloco A - Av. Protásio Alves, 211 - Bloco B e C - Santa Cecília, Porto Alegre - RS, 90035-903 · CNES 2237601

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do MetabolismoDeficiência Intelectual

Hospital Universitário da UFSC (HU-UFSC)

R. Profa. Maria Flora Pausewang - Trindade, Florianópolis - SC, 88036-800 · CNES 2560356

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do Metabolismo

Hospital das Clínicas da FMUSP

R. Dr. Ovídio Pires de Campos, 225 - Cerqueira César, São Paulo - SP, 05403-010 · CNES 2077485

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do MetabolismoDeficiência Intelectual

Hospital de Base de São José do Rio Preto

Av. Brg. Faria Lima, 5544 - Vila Sao Jose, São José do Rio Preto - SP, 15090-000 · CNES 2079798

Atenção Especializada

Rota
Anomalias Congênitas

Hospital de Clínicas da UNICAMP

R. Vital Brasil, 251 - Cidade Universitária, Campinas - SP, 13083-888 · CNES 2748223

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do MetabolismoDeficiência Intelectual

Hospital de Clínicas de Ribeirão Preto (HCRP-USP)

R. Ten. Catão Roxo, 3900 - Vila Monte Alegre, Ribeirão Preto - SP, 14015-010 · CNES 2082187

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do MetabolismoDeficiência Intelectual

UNIFESP / Hospital São Paulo

R. Napoleão de Barros, 715 - Vila Clementino, São Paulo - SP, 04024-002 · CNES 2688689

Serviço de Referência

Rota
Anomalias CongênitasErros Inatos do Metabolismo
Sobre os centros SUS: Estes centros são habilitados pelo Ministério da Saúde como Serviços de Referência em Doenças Raras ou Serviços de Atenção Especializada. O atendimento é pelo SUS, com encaminhamento da rede de atenção básica.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

Pesquisa e ensaios clínicos

8 ensaios clínicos encontrados.

Distribuição por fase
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
277 papers (10 anos)
#1

Peripartum Cardiogenic Shock From Effusive-Constrictive Pericarditis Requiring VA-ECMO and Pericardiectomy.

Circulation. Heart failure2026 Feb 20
#2

Conduction system pacing in a congenital heart block patient with epicardial left ventricular pacing heart failure.

European heart journal. Case reports2026 Feb
#3

Role of Hydroxychloroquine in Prevention of Congenital Heart Block in Pregnant Women With Positive Anti-Ro/SSA and/or Anti-La/SSB.

The Australian &amp; New Zealand journal of obstetrics &amp; gynaecology2026 Apr

Neonatal lupus, a condition primarily affecting infants born to mothers with anti-Ro/SSA and/or anti-La/SSB antibodies, is linked to congenital heart block (CHB), a potentially life-threatening complication. Hydroxychloroquine (HCQ), an antimalarial with immunomodulatory properties, has been shown to reduce CHB recurrence. This review examines current evidence on HCQ's role in preventing CHB in pregnancies affected by those autoantibodies, focusing on overall, primary and secondary prevention. Evidence supports HCQ in overall and secondary prevention, but data on its effectiveness for primary prevention is lacking. Clinical guidelines, antibody titre thresholds, foetal heart rate monitoring and the need for randomised controlled trials are discussed.

#4

Skin-Limited Neonatal Lupus in an Infant Conceived by In Vitro Fertilization and Surrogate Gestation.

Pediatric dermatology2026 Mar 09

Neonatal lupus erythematosus (NLE) is a rare autoimmune condition caused by the transplacental passage of maternal anti-Ro/SSA and anti-La/SSB antibodies, typically presenting with annular erythema or congenital heart block. We report a 3-month-old infant conceived by in vitro fertilization and carried by a surrogate mother who developed annular erythematous plaques in typical and atypical locations at 1 month of age. Skin biopsy and serologic testing confirmed NLE despite the absence of a known maternal autoimmune history; maternal anti-Ro/SSA and anti-La/SSB positivity was identified retrospectively through the surrogate's obstetrician. The cutaneous findings improved significantly with photoprotection and resolved without systemic involvement.

#5

Systemic Manifestations of Neonatal Lupus in an Infant Born to an Asymptomatic Mother: A Case Report of Anemia and Transaminitis.

The American journal of case reports2026 Feb 26

BACKGROUND Neonatal lupus erythematosus (NLE) is a rare autoimmune disorder caused by the transplacental transfer of maternal autoantibodies, primarily anti-Ro/SSA and anti-La/SSB. Common clinical manifestations include cutaneous lesions and congenital heart block; however, systemic involvement such as anemia and transaminitis remains infrequently reported, particularly in Southeast Asian populations. Diagnosis is often missed, especially in infants born to asymptomatic mothers. CASE REPORT A 1-month-old full-term female infant born via cesarean section presented with annular erythematous skin lesions since birth, distributed across the face, chest, and extremities. Laboratory tests revealed normocytic normochromic anemia, thrombocytopenia, and elevated aspartate aminotransferase/alanine aminotransferase levels. Although the electrocardiogram was normal, echocardiography showed a secundum-type atrial septal defect and mild tricuspid regurgitation. Skin biopsy revealed histopathological features consistent with cutaneous lupus. Both maternal and infant serology were positive for anti-Ro and anti-La antibodies. A diagnosis of cutaneous NLE with systemic manifestations was established. Prednisone therapy at a dose of 0.5 mg/kg/day was initiated, along with education on how to avoid sun exposure. After 2 months of therapy, the skin lesions had resolved, and laboratory parameters had improved. CONCLUSIONS This case highlights the importance of considering NLE as a differential diagnosis in infants presenting with cutaneous lesions and systemic abnormalities, even when the mother is asymptomatic. Early diagnosis and appropriate treatment can prevent complications and support optimal clinical recovery.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC430 artigos no totalmostrando 194

2026

Role of Hydroxychloroquine in Prevention of Congenital Heart Block in Pregnant Women With Positive Anti-Ro/SSA and/or Anti-La/SSB.

The Australian &amp; New Zealand journal of obstetrics &amp; gynaecology
2026

Skin-Limited Neonatal Lupus in an Infant Conceived by In Vitro Fertilization and Surrogate Gestation.

Pediatric dermatology
2026

Systemic Manifestations of Neonatal Lupus in an Infant Born to an Asymptomatic Mother: A Case Report of Anemia and Transaminitis.

The American journal of case reports
2026

Association between maternal anti-Ro and anti-La antibody levels and congenital heart block: a 20-year cohort study.

Archives of gynecology and obstetrics
2026

Peripartum Cardiogenic Shock From Effusive-Constrictive Pericarditis Requiring VA-ECMO and Pericardiectomy.

Circulation. Heart failure
2026

Conduction system pacing in a congenital heart block patient with epicardial left ventricular pacing heart failure.

European heart journal. Case reports
2026

Fetal echocardiographic surveillance in anti-SSA/Ro-SSB/La-Positive systemic lupus erythematosus pregnancies: risk stratification of congenital heart block.

Rheumatology (Oxford, England)
2025

Case Report: A multidisciplinary, protocol-driven pathway from recurrent pregnancy loss to live birth in an anti-Ro/SSA-positive primary Sjögren's syndrome pregnancy with literature review.

Frontiers in immunology
2026

Heart Block in Pregnancy From Parvovirus B19.

JACC. Case reports
2026

Prediction of foetal atrioventricular conduction using maternal disease, treatment and anti-Ro/La autoantibody levels.

Rheumatology (Oxford, England)
2025

Atrioventricular block in the newborn period.

HeartRhythm case reports
2025

Case Report: The case of atypical OAPS complicated by positive anti-SSA and anti-SSB antibodies.

Frontiers in immunology
2026

Current and future interventions for neonatal lupus: A review of the national library of Medicine's clinical trials database.

Lupus
2026

Hydroxychloroquine After Complete Heart Block Diagnosis and Relationship to Patient Outcomes: A Descriptive Cohort Study.

Prenatal diagnosis
2025

Maternal Primary Sjögren's Syndrome Complicated by Irreversible Fetal Third-Degree Congenital Heart Block: A Case Report From Nepal.

Clinical case reports
2025

A Multi-Institutional Case Series of Neonatal Lupus Erythematosus Without Cardiac Involvement From Vietnam.

Case reports in pediatrics
2025

Heartbeat of hope: newborn's journey with a pacemaker.

BMJ case reports
2025

Autoimmune antibodies in arrhythmia: a narrative review of potential therapeutic targets to prevent overtreatment.

Cardiovascular diagnosis and therapy
2026

Hydroxychloroquine in systemic lupus erythematosus, anti-SSA/SSB, and antiphospholipid antibody-positive pregnancies.

American journal of obstetrics and gynecology
2025

Fetal and maternal adverse cardiac outcomes in rheumatic diseases: A systematic review.

European journal of obstetrics, gynecology, and reproductive biology
2025

Assessment of fetal left ventricular function in pregnancies with Anti-Ro/SSA or Anti-La/SSB antibodies using velocity vector imaging.

BMC pregnancy and childbirth
2025

Flail Tricuspid and Mitral Valve in Neonatal Lupus.

JACC. Case reports
2026

Safety and Feasibility of Implanting Dual-Chamber Permanent Pacemakers in Patients Under 3 kg.

World journal for pediatric &amp; congenital heart surgery
2025

Pregnancy Outcomes in Women With Systemic Lupus Erythematosus (SLE): A Matched-Observational Study From India.

International journal of rheumatic diseases
2025

Effects of maternal anti-Ro/La antibodies on fetal atrioventricular conduction evaluated with echocardiography: a state-of-the-art review.

Archives of gynecology and obstetrics
2025

Congenital Complete Heart Block Requiring Temporary Pacemaker Placement at Birth: A Case Report.

Seminars in cardiothoracic and vascular anesthesia
2025

Prevention and treatment of autoimmune-mediated congenital heart block: practice provider survey from UK cardiac centres.

Archives of disease in childhood. Fetal and neonatal edition
2025

One step closer to predicting autoimmune congenital heart block?

The Lancet. Rheumatology
2025

Maternal autoantibodies to the sodium potassium pump α1 subunit AT1A1 and fetal autoimmune congenital heart block: a case-control study.

The Lancet. Rheumatology
2025

Neonatal Lupus Erythematosus With Congenital Heart Block.

Journal of cutaneous medicine and surgery
2025

Adverse Pregnancy Outcomes in Sjogren's Disease Compared to Controls: An Interdisciplinary Approach with Maternal-Fetal Medicine.

AJP reports
2025

Clinical characteristics of neonatal lupus erythematosus complicated by congenital heart block: a multi-center retrospective study in East China.

Scientific reports
2025

Neonatal lupus erythematosus presenting with congenital heart block: clinical characteristics and follow-up.

Clinical rheumatology
2025

A 1-year review of anti-Ro/La autoantibody testing in an obstetric population.

Irish journal of medical science
2025

When should a neonatologist consult a rheumatologist?

European journal of pediatrics
2025

Neonatal lupus erythematosus: an acquired autoimmune disease to be taken seriously.

Annals of medicine
2025

Immune and non-immune congenital heart block: a tale of two very different entities.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
2025

Dual- vs Single-Chamber Ventricular Pacing in Isolated Congenital Complete Atrioventricular Block in Infancy.

JACC. Clinical electrophysiology
2025

Treatment options for preventing autoimmune-mediated congenital heart block: a systematic review.

Archives of disease in childhood
2025

Spontaneous conversion of fetal heart block to sinus rhythm post externalized pacemaker placement in an undiagnosed mother with lupus antibodies.

The journal of maternal-fetal &amp; neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
2025

Maternal autoimmune systemic connective tissue disease and vasculitis and electrocardiographic findings in the offspring.

Journal of autoimmunity
2024

Myocardial perfusion imaging in a case of cardiac strangulation: A novel approach to detect pacemaker-induced ischemia.

Annals of pediatric cardiology
2024

Constrictive pericarditis following epicardial pacemaker implant: a diagnostic dilemma.

Cardiology in the young
2025

Dual Chamber Aveir Retrievable Leadless Pacemaker Implant via the Right Internal Jugular Vein in a 13-Year-Old With Congenital Complete Heart Block.

Pacing and clinical electrophysiology : PACE
2025

Neonatal lupus erythematosus: 24 years of experience from a tertiary centre at Chandigarh, North India.

Lupus
2025

Subxiphoid Insertion of a Pediatric Implantable Pulse Generator in a Neonate With Congenital Complete Heart Block.

World journal for pediatric &amp; congenital heart surgery
2024

Neonatal lupus erythematosus successfully treated by exchange transfusion: a case report and literature review.

Frontiers in pediatrics
2024

Impact of early detection and steroid treatment on fetal ventricular heart rate and pacemaker implantation in anti-Ro/SSA positive congenital heart block.

Acta obstetricia et gynecologica Scandinavica
2024

"An update on the approach to treatment of Sjogren's Disease in pregnancy".

The journal of maternal-fetal &amp; neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
2024

Fetal and Maternal Outcomes in a Cohort of Patients With Primary Sjogren's Syndrome: An Observational Study.

Cureus
2024

Review of Systemic Lupus Erythematous-Reply.

JAMA
2024

Review of Systemic Lupus Erythematous.

JAMA
2024

Dual challenge inside the womb: a case report of concomitant fetal atrio-ventricular block associated with maternal anti-SSA antibodies and fetal tachyarrhythmia diagnosed as Wolff-Parkinson-White syndrome after birth.

Frontiers in immunology
2024

Sjogren's Antibodies and Neonatal Lupus: A Scoping Review.

Cureus
2024

Dysregulation of immune checkpoint molecules as a characteristic of autoimmune congenital heart block.

Annals of the rheumatic diseases
2024

Complete Congenital Heart Block in the Offspring of an Asymptomatic Woman with Isolated High Titer Anti-Ro Antibody.

Acta medica Philippina
2024

Congenital Complete Heart Block-To Stimulate (When?) or Not to Stimulate?

Healthcare (Basel, Switzerland)
2024

Complex Presentation of Congenital Heart Block and Coexisting Congenital Heart Disease in a One-Year-Old Girl: A Case Report.

Cureus
2024

Molecular Mechanisms of Fetal and Neonatal Lupus: A Narrative Review of an Autoimmune Disease Transferal across the Placenta.

International journal of molecular sciences
2024

Comparing pregnancy outcomes in patients with Systemic Lupus Erythematosus (SLE) and Undifferentiated Connective Tissue Disease (UCTD): a descriptive cohort study.

Revista clinica espanola
2024

Management of pregnancy in autoimmune rheumatic diseases: maternal disease course, gestational and neonatal outcomes and use of medications in the prospectiveItalian P-RHEUM.it study.

RMD open
2024

Isolated non-immune-mediated second-degree atrioventricular block in the fetus: natural history and predictive factors for spontaneous recovery.

Ultrasound in obstetrics &amp; gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
2024

Home monitoring of fetal heart rhythm: Lived experiences of women with anti-SSA/Ro52 autoantibodies and their co-parents.

Lupus
2024

Subclinical maternal autoimmune disease leading to congenital high degree atrioventricular block: Case report and review of the literature.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
2024

Prevalence of neonatal lupus in a small group of antibody-carrying mothers and frequency of complete atrioventricular block.

Archivos de cardiologia de Mexico
2024

Late-Onset Dilated Cardiomyopathy in Auto Immune-Mediated Complete Congenital Heart Block: A Case Report.

Cureus
2024

Critical congenital heart disease: contemporary prenatal screening performance and outcomes in a multi-centre perinatology service.

BMC pregnancy and childbirth
2024

Newborns with congenital complete heart block: Advice for perinatal care providers.

Tropical doctor
2024

A novel miniaturized adult pacemaker system for small neonates with congenital heart block.

JTCVS techniques
2024

Autoimmune congenital heart block: a case report and review of the literature related to pathogenesis and pregnancy management.

Arthritis research &amp; therapy
2023

[Clinical characteristics of fetal cardiac disease in patients with anti-SSA antibody positive].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
2023

Pregnancy and Inflammatory Rheumatological Diseases: A Single-Center Retrospective Cohort Study.

Cureus
2023

Experience of treating congenital complete atrioventricular block with epicardial pacemaker in infants and young children: a retrospective study.

BMC cardiovascular disorders
2024

Longitudinal echocardiographic parameters before and after pacemaker placement in congenital complete heart block.

Heart rhythm
2024

Expert Perspective on a Clinical Challenge: Lupus and Pregnancy.

Arthritis &amp; rheumatology (Hoboken, N.J.)
2023

Reverse complete heart block using transcutaneous pacing and repeated plasmapheresis in a neonate with lupus: a case report.

Pediatric rheumatology online journal
2024

Perivascular Basal Echogenicity in the Fetal Heart: An Unconventional Marker of Maternal Autoimmune Antibodies.

Pediatric cardiology
2023

Epicardial pacing lead implantation for congenital complete atrioventricular block immediately after birth: a case report.

Journal of medical case reports
2023

Congenital Heart Block and Its Association With Anti-Ro and Anti-La Antibodies in Pregnancy: A Case Report of a Rare Entity and a Review of the Current Evidence.

Cureus
2023

Pregnancy Outcomes in Patients with Primary Sjögren's Syndrome Undergoing Assisted Reproductive Therapy: A Multi-center Retrospective Study.

Rheumatology and therapy
2023

Neonatal lupus erythematosus manifested as a complete heart block: A case report.

Clinical case reports
2023

The role of cardiac anaesthesiologists in placing a temporary transvenous endocardial lead in the operation room during pulse generator replacement in a child with congenital complete heart block.

Annals of cardiac anaesthesia
2023

Reversible complete atrioventricular block in a neonate with maternal anti-Sjögren's syndrome-associated antibody: atypical phenotype of autoimmune congenital heart block.

Cardiology in the young
2023

Percutaneous extraction of a protruding atrial pacing lead in an 8-year-old child.

Journal of cardiology cases
2023

Placement of permanent pacemaker in a low-birth-weight infant with congenital heart block: a case report.

JPMA. The Journal of the Pakistan Medical Association
2023

Case report: Challenges and implications of conduction system pacing in pediatrics: Case series.

Frontiers in pediatrics
2023

Autoimmune Congenital Complete Heart Block: How Late Can It Occur?

AJP reports
2023

Emergency pacing via the umbilical vein of a neonate with congenital complete atrioventricular block: a report of two cases.

Cardiology in the young
2023

Contribution of S100A4-expressing fibroblasts to anti-SSA/Ro-associated atrioventricular nodal calcification and soluble S100A4 as a biomarker of clinical severity.

Frontiers in immunology
2023

Identifying Congenital Heart Block in Primary Care.

Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates &amp; Practitioners
2023

Maternal and infant outcomes of pregnancy associated with anti-SSA/RO antibodies: a systematic review and meta-analysis.

Pediatric rheumatology online journal
2023

Pediatric Epicardial Devices: Early and Midterm Outcomes.

World journal for pediatric &amp; congenital heart surgery
2022

Neonatal lupus erythematosus - prevention is better than cure.

Postepy dermatologii i alergologii
2023

Ventricular Functional Analysis in Congenital Complete Heart Block Using Speckle Tracking: Left Ventricular Epicardial Compared to Right Ventricular Septal Pacing.

Pediatric cardiology
2023

Successful Pregnancy with SLE-associated Antiphospholipid Syndrome: A Case Report.

Mymensingh medical journal : MMJ
2023

A Case of Neonatal Lupus Presenting with Myocardial Dysfunction in the Absence of Congenital Heart Block (CHB): Clinical Management and Brief Literature Review of Neonatal Cardiac Lupus.

Pediatric cardiology
2022

Sjögren's syndrome and pregnancy: a Portuguese case-control study.

Reumatologia
2023

Anti-SSA/Ro positivity and congenital heart block: obstetric and foetal outcome in a cohort of anti-SSA/Ro positive pregnant patients with and without autoimmune diseases.

Clinical and experimental rheumatology
2022

Neonatal Lupus presenting with neonatal hemochromatosis-like liver disease that responded to steroids: a case report.

BMC pediatrics
2023

miR Profile of Chronic Right Ventricular Pacing: a Pilot Study in Children with Congenital Complete Atrioventricular Block.

Journal of cardiovascular translational research
2022

Fetal Arrhythmia Diagnosis and Pharmacologic Management.

Journal of clinical pharmacology
2023

Favourable outcome of a severe bradyarrhythmia in a neonate: a case report.

Cardiology in the young
2022

Short and long-term outcomes of children with autoimmune congenital heart block treated with a combined maternal-neonatal therapy. A comparison study.

Journal of perinatology : official journal of the California Perinatal Association
2024

Conduction System Pacing in Pediatrics and Congenital Heart Disease, a Single Center Series of 24 Patients.

Pediatric cardiology
2022

Health Outcomes of 215 Mothers of Children With Autoimmune Congenital Heart Block: Analysis of the French Neonatal Lupus Syndrome Registry.

The Journal of rheumatology
2022

Pregnancy outcomes of a joint obstetric and rheumatology clinic in a tertiary centre: a 2-year retrospective study of 98 pregnancies.

Rheumatology advances in practice
2022

Auxilin is a novel susceptibility gene for congenital heart block which directly impacts fetal heart function.

Annals of the rheumatic diseases
2022

Histological finding of maternal antibody-associated congenital heart block accompanied by large atrial septal defect and severe cardiac dysfunction.

Cardiology in the young
2022

Success with caution: Forty years of congenital complete atrioventricular block.

Heart rhythm
2022

Transvenous laser lead extraction in patients with congenital complete heart block.

Heart rhythm
2022

His Bundle pacing for congenital complete AV block: An attempt to fix a broken heart?

Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc
2022

Incidence of morbidity and mortality in a cohort of congenital complete heart block patients followed over 40 years.

Heart rhythm
2022

Anti-Ro52 Autoantibody Is Common in Systemic Autoimmune Rheumatic Diseases and Correlating with Worse Outcome when Associated with interstitial lung disease in Systemic Sclerosis and Autoimmune Myositis.

Clinical reviews in allergy &amp; immunology
2022

NAFTNet retrospective report on the treatment of anti-Ro/SSA mediated fetal heart block with dexamethasone.

The journal of maternal-fetal &amp; neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
2022

Prenatal predisposing factors associated with neonatal lupus erythematosus.

Lupus
2021

[Detection and prevention of maternal autoantibody-related congenital heart block].

Zhonghua xin xue guan bing za zhi
2021

Systemic erythematosus lupus and pregnancy outcomes in a Colombian cohort.

Lupus
2021

Complete heart block in neonatal lupus: a forgotten cause of fetal bradycardia.

BMJ case reports
2022

Cohort study of congenital complete heart block among preterm neonates: a single-center experience over a 15-year period.

European journal of pediatrics
2021

Systemic lupus erythematosus and pregnancy: A retrospective single-center study of 215 pregnancies from Portugal.

Lupus
2021

Fetal Congenital Heart Block Associated With Maternal Primary Systemic Lupus Erythematosus and Sjogren's Syndrome.

Cureus
2022

Third Trimester Fetal Heart Rates in Antibody-Mediated Complete Heart Block Predict Need for Neonatal Pacemaker Placement.

Pediatric cardiology
2021

Clinical utility of fetal echocardiography: an Egyptian center experience.

The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology
2021

Ventricular pacing and myocardial function in patient with congenital heart block.

Journal of cardiovascular electrophysiology
2021

Ventricular pacing and myocardial function in patients with congenital heart block: Is it time to consider de novo biventricular pacing?

Journal of cardiovascular electrophysiology
2021

Low prevalence of anti-SSA (anti-Ro) and anti-SSB (anti-La) autoantibodies in female patients with rheumatoid arthritis with a wish to conceive.

RMD open
2021

Early-Onset Cardiomyopathy After Pacemaker Implanted in a Preterm Infant With Congenital Complete Heart Block and Anti-Ro/SSA Antibodies.

Texas Heart Institute journal
2021

Prenatal Management Strategy for Immune-Associated Congenital Heart Block in Fetuses.

Frontiers in cardiovascular medicine
2021

His Bundle Pacing in Congenital Complete Heart Block: Making HIStory?

JACC. Clinical electrophysiology
2021

Temporary pacemaker implantation through umbilical vein in a low birth weight neonate with congenital complete heart block.

Cardiology in the young
2021

Ethnicity and Neonatal Lupus Erythematosus Manifestations Risk in a Large Multiethnic Cohort.

The Journal of rheumatology
2021

Successful 2-Stage Pacemaker Implantation for Atrioventricular Block in a Low-Birth-Weight Infant with Congenital Heart Disease: Case Report.

The heart surgery forum
2021

Case series of late lead dislodgement of Medtronic SelectSecure 3830 pacing leads in growing paediatric patients.

European heart journal. Case reports
2021

Successful perinatal management and pacemaker stimulation during the first hour of life in a 1.6 kg newborn with autoimmune congenital complete heart block diagnosed prenatally.

Ginekologia polska
2021

First trimester combined screening test for aneuploidies in anti-Ro carriers pregnant women.

Clinical rheumatology
2021

Home fetal heart rate monitoring in anti Ro/SSA positive pregnancies: Literature review and case report.

European journal of obstetrics, gynecology, and reproductive biology
2021

Bosentan-induced immune hemolytic anemia in 17 years old man. A case report.

Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences
2021

Neonatal lupus erythematosus - practical guidelines.

Journal of perinatal medicine
2020

Maternal and Fetal Outcomes in Systemic Lupus Erythematosus Pregnancies.

Annals of the Academy of Medicine, Singapore
2020

Autoimmune Congenital Heart Block: A Review of Biomarkers and Management of Pregnancy.

Frontiers in pediatrics
2021

Permanent His Bundle Pacing in Patients With Congenital Complete Heart Block: A Multicenter Experience.

JACC. Clinical electrophysiology
2021

Longitudinal Analysis of Fetal Ventricular Rate for Risk Stratification in Immune Congenital Heart Block.

Fetal diagnosis and therapy
2021

False Asystole Alarms Post-Temporary Pacemaker Placement Due to Pseudo-fusion.

Pediatric cardiology
2022

Long-term physical and neurodevelopmental outcomes after antenatal betamethasone administration for congenital heart block prevention.

The journal of maternal-fetal &amp; neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
2021

Pulmonary hypertension associated with congenital heart block and neonatal lupus syndrome: A series of four cases.

Lupus
2021

Interferons and innate immune activation in autoimmune congenital heart block.

Scandinavian journal of immunology
2020

Elective Inguinal Hernia Surgery in the Setting of Unfollowed Congenital Complete Heart Block With No Postponement.

Cureus
2021

Umbilical and Middle Cerebral Artery Doppler Measurements in Fetuses With Congenital Heart Block.

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography
2022

Clinical Features, Autoantibodies, and Outcome of Neonatal Lupus Erythematosus.

Fetal and pediatric pathology
2020

A novel technique for extraction of a leadless pacemaker that embolized to the pulmonary artery in a young patient: A case report.

HeartRhythm case reports
2020

Autoimmune congenital heart block and primary Sjögren's syndrome: characterisation and outcomes of 49 cases.

Clinical and experimental rheumatology
2021

Natural killer cells and type II interferon in Ro/SSA and La/SSB autoantibody-exposed newborns at risk of congenital heart block.

Annals of the rheumatic diseases
2020

Mortality in congenital heart block - Authors' reply.

The Lancet. Rheumatology
2020

Mortality in congenital heart block.

The Lancet. Rheumatology
2020

Primary Sjögren's syndrome in South Australia.

Clinical and experimental rheumatology
2020

Electrocardiographic QT Intervals in Infants Exposed to Hydroxychloroquine Throughout Gestation.

Circulation. Arrhythmia and electrophysiology
2020

Diagnosis and Management of Fetal Autoimmune Atrioventricular Block.

International journal of women's health
2021

The importance of lead management in the young paced patient. The case of a 22-year-old female with congenital complete heart block.

Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese
2020

Congenital complete heart block in the setting of severe pre-eclampsia requiring urgent cesarean section.

International journal of obstetric anesthesia
2020

Congenital Heart Block in Subsequent Pregnancies of SSA/Ro-Positive Mothers: Cutting Recurrence in Half.

Journal of the American College of Cardiology
2020

Hydroxychloroquine to Prevent Recurrent Congenital Heart Block in Fetuses of Anti-SSA/Ro-Positive Mothers.

Journal of the American College of Cardiology
2020

A Broader Perspective on Anti-Ro Antibodies and Their Fetal Consequences-A Case Report and Literature Review.

Diagnostics (Basel, Switzerland)
2020

Treatment and follow-up of fetuses that developed congenital heart block due to autoantibody in two cases.

The Journal of international medical research
2020

Fluorinated steroids are not superior to any treatment to ameliorate the outcome of autoimmune mediated congenital heart block: a systematic review of the literature and meta-analysis.

Clinical and experimental rheumatology
2020

A missense mutation of ErbB2 produces a novel mouse model of stillbirth associated with a cardiac abnormality but lacking abnormalities of placental structure.

PloS one
2020

Commentary: First Report of the Italian Registry on Immune-Mediated Congenital Heart Block (Lu.Ne Registry).

Frontiers in cardiovascular medicine
2020

Congenital Complete Atrioventricular Heart Block in a Pregnant Woman with Sjögren Syndrome: Prenatal Care Follow-Up and the Challenge of Intrauterine Treatment.

Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia
2020

Left ventricular (LV) pacing in newborns and infants: Echo assessment of LV systolic function and synchrony at 5-year follow-up.

Pacing and clinical electrophysiology : PACE
2020

Surveillance of congenital heart block in highly specialised care - Authors' reply.

The Lancet. Rheumatology
2020

Surveillance of congenital heart block in highly specialised care.

The Lancet. Rheumatology
2020

Permanent left bundle branch pacing: What is the mechanism of divergent responses during programmed stimulation?

Journal of cardiovascular electrophysiology
2020

Umbilical artery catheter, aortic dissection, carotid cannulation, and pseudoaneurysm in a neonate: A tale of propagating pathology.

Annals of pediatric cardiology
2020

Type I IFN system activation in newborns exposed to Ro/SSA and La/SSB autoantibodies in utero.

RMD open
2020

A multicentre study of 244 pregnancies in undifferentiated connective tissue disease: maternal/fetal outcomes and disease evolution.

Rheumatology (Oxford, England)
2020

Geoepidemiology and clinical characteristics of neonatal lupus erythematosus: a systematic literature review of individual patients’ data.

Turkish journal of medical sciences
2019

Arrhythmia and/or Cardiomyopathy Related to Maternal Autoantibodies: Descriptive Analysis of a Series of 16 Cases From a Single Center.

Frontiers in pediatrics
2021

Pregnancy control in patients with systemic lupus erythematosus/antiphospholipid syndrome. Part 2: Pregnancy follow-up.

Reumatologia clinica
2020

Long-term Follow-up of Epicardial Pacing and Left Ventricular Dysfunction in Children With Congenital Heart Block.

The Annals of thoracic surgery
2020

Autoimmune-mediated congenital heart block.

Best practice &amp; research. Clinical obstetrics &amp; gynaecology
2020

Pregnancy and Systemic Lupus Erythematosus.

Best practice &amp; research. Clinical obstetrics &amp; gynaecology
2019

Routine repeated echocardiographic monitoring of fetuses exposed to maternal anti-SSA antibodies: time to question the dogma.

The Lancet. Rheumatology
2020

Cell atlas of the foetal human heart and implications for autoimmune-mediated congenital heart block.

Cardiovascular research
2019

Therapeutic apheresis during pregnancy: A single center experience.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis
2019

Use of antenatal fluorinated corticosteroids in management of congenital heart block: Systematic review and meta-analysis.

European journal of obstetrics &amp; gynecology and reproductive biology: X
2019

[Cardiac Strangulation Induced by Epicardial Pacemaker Leads Causing Heart Failure;Report of a Case].

Kyobu geka. The Japanese journal of thoracic surgery
2019

Minimally invasive technique of placing a dual chamber permanent pacemaker in children.

JPMA. The Journal of the Pakistan Medical Association
2019

Aetiologies and temporal trends of atrioventricular block in young patients: a 20-year nationwide study.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
2019

Cesarean delivery in congenital heart block and need of temporary pacing: A case report.

Saudi journal of anaesthesia
2019

Keeping upbeat to prevent the heartbreak of anti-Ro/SSA pregnancy.

Ultrasound in obstetrics &amp; gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
2020

Effects of maternal medication on long-term outcome in congenital heart block remain to be established. Response to: 'Comorbidity and long-term outcome in patients with congenital heart block and their siblings exposed to Ro/SSA autoantibodies in utero' by Satis et al.

Annals of the rheumatic diseases
2020

Congenital heart block: Pace earlier (Childhood) than later (Adulthood).

Trends in cardiovascular medicine
2019

Unconventional 2:1 Ventricular Pacing in a Neonate with Congenital Heart Block and Biventricular Noncompaction.

Texas Heart Institute journal
2020

Comorbidity and long-term outcome in patients with congenital heart block and their siblings exposed to Ro/SSA autoantibodies in utero.

Annals of the rheumatic diseases
2019

Pregnancy outcomes in mixed connective tissue disease: a multicentre study.

Rheumatology (Oxford, England)
Ver todos os 430 no EuropePMC

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Doenças relacionadas

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Ordenadas pelo número de sintomas em comum.

Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Peripartum Cardiogenic Shock From Effusive-Constrictive Pericarditis Requiring VA-ECMO and Pericardiectomy.
    Circulation. Heart failure· 2026· PMID 41717678mais citado
  2. Conduction system pacing in a congenital heart block patient with epicardial left ventricular pacing heart failure.
    European heart journal. Case reports· 2026· PMID 41717125mais citado
  3. Role of Hydroxychloroquine in Prevention of Congenital Heart Block in Pregnant Women With Positive Anti-Ro/SSA and/or Anti-La/SSB.
    The Australian &amp; New Zealand journal of obstetrics &amp; gynaecology· 2026· PMID 41879307mais citado
  4. Skin-Limited Neonatal Lupus in an Infant Conceived by In&#xa0;Vitro Fertilization and Surrogate Gestation.
    Pediatric dermatology· 2026· PMID 41802920mais citado
  5. Systemic Manifestations of Neonatal Lupus in an Infant Born to an Asymptomatic Mother: A Case Report of Anemia and Transaminitis.
    The American journal of case reports· 2026· PMID 41742631mais citado
  6. The Prevalence of Fetal Complete Heart Block and the Role of Positive Autoantibodies in Pregnant Women with Rheumatologic Diseases.
    J Obstet Gynaecol India· 2026· PMID 41970440recente
  7. Maternal and fetal outcomes in pregnancies affected by mixed connective tissue disease.
    Obstet Med· 2026· PMID 41940214recente
  8. Prenatal Diagnosis of Immune-Mediated Fetal Complete Heart Block Revealing Maternal Systemic Lupus Erythematosus.
    Cureus· 2026· PMID 41918634recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:60041(Orphanet)
  2. OMIM OMIM:234700(OMIM)
  3. MONDO:0009326(MONDO)
  4. GARD:6164(GARD (NIH))
  5. Busca completa no PubMed(PubMed)
  6. Q18558252(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Bloqueio cardíaco congênito
Compêndio · Raras BR

Bloqueio cardíaco congênito

ORPHA:60041 · MONDO:0009326
Prevalência
Unknown
Herança
Not applicable
CID-10
Q24.6 · Bloqueio congênito do coração
CID-11
Início
Infancy, Neonatal
Prevalência
0.0 (Worldwide)
MedGen
UMLS
C0149530
Repurposing
1 candidato
isoprenalineadrenergic receptor agonist
EuropePMC
Wikidata
Papers 10a
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