Raras
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Legionelose
ORPHA:600832CID-10 · A48.1CID-11 · 1C19DOENÇA RARA

Qualquer doença causada pela bactéria Legionella.

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Introdução

O que você precisa saber de cara

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Qualquer doença causada pela bactéria Legionella.

Pesquisas ativas
1 ensaio
7 total registrados no ClinicalTrials.gov
Publicações científicas
520 artigos
Último publicado: 2026
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SUS: Sem cobertura SUSScore: 0%
CID-10: A48.1
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Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

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Digestivo
6 sintomas
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Pulmão
5 sintomas
❤️
Coração
4 sintomas
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Rins
3 sintomas
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Músculos
2 sintomas
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Sangue
2 sintomas

+ 17 sintomas em outras categorias

Características mais comuns

Cefaleia
Febre
Tosse
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Pneumonia
44sintomas
Sem dados (44)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 44 características clínicas mais associadas, ordenadas por frequência.

CefaleiaHeadache
FebreFever
TosseCough
MialgiaMyalgia
FadigaFatigue

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico520PubMed
Últimos 10 anos178publicações
Pico202525 papers
Linha do tempo
2026Hoje · 2026🧪 2007Primeiro ensaio clínico📈 2025Ano de pico
Publicações por ano (últimos 10 anos)

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Genética e causas

O que está alterado no DNA e como passa nas famílias

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🇧🇷 Atendimento SUS — Legionelose

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Pesquisa e ensaios clínicos

7 ensaios clínicos encontrados, 1 ativos.

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Publicações mais relevantes

Timeline de publicações
180 papers (10 anos)
#1

Fulminant Rhabdomyolysis and Acute Kidney Injury Associated With Pontiac Fever: A Case Report.

Cureus2026 Feb

Legionella pneumophila typically manifests in two distinct clinical forms: Legionnaires' disease, characterized by severe pneumonia, and Pontiac fever (PF), a non-pneumonic, influenza-like illness that is usually self-limiting within 2-5 days. While PF is characterized by a high attack rate among exposed individuals in outbreak settings, its true incidence remains unknown and is likely underdiagnosed. Consequently, in routine surveillance data, Legionnaires' disease accounts for the vast majority of reported Legionella infections, with PF representing only a negligible fraction. We report a rare case of a 24-year-old man who presented with high fever, myalgia, and gastrointestinal distress, subsequently developing fulminant rhabdomyolysis. Laboratory findings were remarkable for a peak creatine kinase (CK) level of 737,860 U/L and Kidney Disease: Improving Global Outcomes (KDIGO) stage III acute kidney injury (AKI) requiring renal replacement therapy. Despite the complete absence of pulmonary involvement or hypoxemia, serological testing performed during outpatient follow-up retrospectively confirmed Legionella infection. This case emphasizes that PF, despite its reputation as a mild illness, can rarely precipitate life-threatening systemic muscle destruction and multi-organ dysfunction.

#2

Frequency of rhabdomyolysis in Legionella infection and associated outcomes: a retrospective cross-sectional study.

Postgraduate medicine2026 Jan

Legionella is a common cause of community-acquired pneumonia and can affect multiple organ systems. An association with rhabdomyolysis and acute kidney injury (AKI) have been noted for several decades, but population-based studies are limited and could aid in better understanding the prevalence, associated risk factors, and clinical significance of this complication. We performed a retrospective manual review of the electronic health record on 323 patients with legionellosis identified on the basis of urinary antigen or culture in a large, urban hospital system. Demographic and clinical data were extracted by four physician reviewers. Rhabdomyolysis was assessed on the basis of creatine kinase (CK) values ≥1,000 IU/L or suggestive urinalysis findings. AKI was classified according to Kidney Disease: Improving Global Outcomes (KDIGO) guidelines. Patients were excluded for missing data or potential alternative causes of rhabdomyolysis. Data were analyzed using appropriate parametric and non-parametric statistical tests and multivariate logistic regression analysis. A total of 210 patients were included in the analysis. Fifty patients (23.8%) had evidence of rhabdomyolysis, 20% of whom had severe rhabdomyolysis (CK ≥15,000 IU/L). Rhabdomyolysis was associated with male sex, black race, and age <65. Common comorbidities were not associated with rhabdomyolysis. Rhabdomyolysis was associated with AKI, including for mild cases (CK 1000-5000 IU/L), with longer hospital length of stay, and with higher likelihood of intensive care unit admission, but not with overall mortality, which was 5.1% in the patient cohort. Rhabdomyolysis is a common feature of legionellosis, is associated with AKI, and may be a marker of more severe disease.

#3

Diagnostic methods and therapeutics strategies of Legionella infection in postbone marrow transplantation.

Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences2025

Organ transplantation represents a critical therapeutic intervention for patients with end-stage organ failure or hematological malignancies, often serving as a last-resort treatment. Among these, bone marrow transplantation (BMT) is vital but complex, as it induces profound and long-lasting immunosuppression. Patients undergoing BMT are highly vulnerable to opportunistic infections due to concurrent chemotherapy, radiation, and immunosuppressive therapies. Legionella infections emerge as a significant threat, accounting for considerable morbidity and mortality in hospitalized immunocompromised individuals. These infections often progress rapidly to severe pneumonia, with high mortality rates compared to those infecting immunocompetent people. Early and accurate diagnosis remains challenging due to nonspecific clinical presentations and limitations of conventional microbiological methods. Consequently, timely detection using advanced diagnostic tools and therapeutic intervention is necessary. This comprehensive review critically observes the epidemiology, risk factors, diagnostic methods, clinical manifestations, and treatments of Legionella in BMT recipients. It emphasizes the need for institutional prevention protocols to alleviate the exposure risks to reduce the burden of Legionella-related complications in high-risk BMT recipients.

#4

A rare cause of dysarthria: Legionnaires' disease.

The International journal of neuroscience2025 Feb

A case admitted with dysarthria and syncope and hyperintense lesion in the splenium of the corpus callosum, diagnosed as Legionnaires' disease by detecting Legionella antigen in the urine, and recovered only with antibiotic treatment is presented because it is rare in the literature. When a 64-year-old female patient was admitted to the emergency department with complaints of sudden loss of consciousness and fainting at home, she had speech impairment, and her pulse oxygen saturation in room air was 88%. In the neurological examination, there was no pathological finding except dysarthria in the patient with no motor deficit. The patient had no respiratory complaints and had a recent travel history. In laboratory examinations, hyponatremia was detected with increased C-reactive protein and liver enzymes. Consolidation was observed in the lower right zone on chest computed tomography. Ampicillin + sulbactam (4x1 gr, intravenous) and clarithromycin (2 × 500 mg orally) were initiated. On cranial magnetic resonance, a hyperintense lesion was observed in the splenium of the corpus callosum in the oval T2 sequence. Legionella pneumophila serogroup 1 antigen in urine was reported as positive. On the fourth day of her hospitalization, the patient, whose CRP and liver enzyme values regressed, her hyponatremia improved, her pulse oxygen saturation increased to 92% in room air, and her speech became comprehensible, was discharged after oral antibiotic treatment was arranged. On the 12th day, the speech ability of the patient completely returned to normal. Legionella infection should be suspected in the presence of pneumonia and corpus callosum splenium lesion.

#5

A Case of Legionella Pneumonia Suspected as Typical Pneumonia After Lung Cancer Surgery, Diagnosed by a Repeat Urinary Legionella Antigen Test.

Cureus2025 Nov

Legionella pneumophila is a leading cause of severe atypical pneumonia and is associated with high mortality when initial treatment is inadequate. The urinary Legionella antigen test serves as a rapid, first-line diagnostic tool; however, early results may be negative, and antigen shedding can be intermittent. In these situations, timely retesting is essential, especially in postoperative or high-risk patients. We report the case of a 74-year-old man, a former smoker with diabetes and moderate aortic stenosis, who underwent thoracoscopic left lower lobectomy and was discharged on postoperative day (POD) six. He developed a fever on POD 27, accompanied by right upper lobe pneumonia. Outpatient urinary antigen tests for pneumococcus and Legionella were negative, and oral garenoxacin was initiated. However, hypoxemia and inflammation worsened, resulting in urgent admission on POD 30. Broad-spectrum β-lactams (sulbactam/ampicillin, followed by piperacillin/tazobactam) were ineffective. Chest CT revealed enlarging infiltrates and a parapneumonic effusion requiring drainage, despite negative pleural fluid cultures. Given the persistent deterioration of the patient's condition, levofloxacin was added, and the urinary Legionella antigen test (R70829, MIZUHO MEDY Co., Ltd., Tosu, Japan) was repeated on hospital day five (POD 35), which returned positive, confirming Legionella pneumonia. Subsequent targeted therapy with azithromycin (days 6-8 and 13-15), alongside levofloxacin, resulted in clinical improvement. Despite complications during the clinical course, including acute kidney injury necessitating two hemodialysis sessions and a creatine kinase peak of 1,563 U/L, the chest drain was removed on day 21, oxygen was discontinued by day 31, and the patient was transferred to long-term care on day 54. The sequence of renal failure preceding creatine kinase elevation suggests direct renal involvement by L. pneumophila rather than primary rhabdomyolysis. Vigilant retesting enabled timely pathogen-directed therapy and a favorable outcome. This case report highlights that a single negative urinary antigen test does not rule out Legionella infection. We accordingly recommend early repeat antigen testing, ideally within one week, for postoperative pneumonia unresponsive to β-lactams, together with prompt macrolide or fluoroquinolone therapy.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC133 artigos no totalmostrando 176

2026

Fulminant Rhabdomyolysis and Acute Kidney Injury Associated With Pontiac Fever: A Case Report.

Cureus
2026

Frequency of rhabdomyolysis in Legionella infection and associated outcomes: a retrospective cross-sectional study.

Postgraduate medicine
2025

A Case of Legionella Pneumonia Suspected as Typical Pneumonia After Lung Cancer Surgery, Diagnosed by a Repeat Urinary Legionella Antigen Test.

Cureus
2025

A case of severe cardiogenic shock triggered by Legionella infection treated with veno-arterial extracorporeal membrane oxygenation (VA-ECMO).

The journal of medical investigation : JMI
2025

Impact of COVID-19 pandemic on Legionella testing and infection rates in Ontario.

BMC public health
2025

Severe Legionella pneumonia mimicking immune-related pneumonitis after chemoimmunotherapy for lung cancer: a case report.

Frontiers in oncology
2025

Development and Validation of a High-Throughput Screening Assay for the Legionella ADP-Ribosyl Transferase SdeA.

Chembiochem : a European journal of chemical biology
2025

Diagnostic methods and therapeutics strategies of Legionella infection in postbone marrow transplantation.

Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences
2025

Doxycycline for Legionella Pneumonia: Expanding Treatment Horizons Through a Case Series and Narrative Review.

The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians
2025

Test and treat-impact of microbiological testing on antibiotic prescribing for Legionnaires' disease in Switzerland: results of the multicentre SwissLEGIO study.

Pneumonia (Nathan Qld.)
2025

Legionella pneumonia complicated with severe acute kidney injury requiring continuous renal replacement therapy: a case series.

Journal of medical case reports
2025

A Case of Polymerase Chain Reaction (PCR)-Positive Urine Antigen and Culture-Negative Legionnaires' Disease in an Immunosuppressed Patient.

Cureus
2025

Physicians' degree of awareness regarding the risks, clinical practices, and management challenges of nosocomial legionnaires' disease: A cross-sectional study from two Ethiopian hospitals.

SAGE open medicine
2025

Dendritic cells activate pyroptosis and effector-triggered apoptosis to restrict Legionella infection.

mBio
2025

Phosphoribosyl ubiquitination of SNARE proteins regulates autophagy during Legionella infection.

The EMBO journal
2025

GM-CSF engages multiple signaling pathways to enhance pro-inflammatory cytokine responses in human monocytes during Legionella infection.

Infection and immunity
2025

Lymphadenitis caused by Legionella sainthelensi infection: a case report and literature review.

Frontiers in medicine
2025

A Case of Legionella pneumophila With Hearing Loss Improved by Antimicrobial Therapy.

Cureus
2025

Clinical and epidemiological characteristics of Legionnaires' disease in Southern Sweden, a population-based study.

Infectious diseases (London, England)
2025

[Legionella infection complicating acute lymphoblastic leukemia: a case report].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
2025

Legionnaire's Disease Beyond the Lungs: A Rare Case of Severe Rhabdomyolysis and Acute Kidney Injury from a Possible Vaping Source.

Hospital pharmacy
2025

Omadacycline for the Treatment of Severe Legionella Pneumonia Complicated with Multiple Organ Failure: A Case Report.

International medical case reports journal
2025

Sprinkler irrigation of urban sport fields as a potential source of Legionella.

Archives of environmental &amp; occupational health
2024

Legionnaires' Disease Presenting With Acute Kidney Injury: Successful Treatment With Antibiotics.

Cureus
2025

Incorporating Incubation Period Distributions to Precisely Estimate the Association Between Rainfall and Legionella Infection.

The Journal of infectious diseases
2024

Native Valve Legionella Endocarditis in a 74-Year-Old Male: A Case Report and Review.

Cureus
2024

Insights into the role of legionella effectors on host metabolic perturbations.

Frontiers in cellular and infection microbiology
2024

Uncovering Gaps in Knowledge: A Survey of Belgian General Practitioners' Awareness of Legionnaires' Disease Diagnostic Testing.

Infectious disease reports
2025

Serine ubiquitination of SQSTM1 regulates NFE2L2-dependent redox homeostasis.

Autophagy
2024

A Case of Legionella Pneumonia with Rhabdomyolysis, with Extremely high Creatinine Kinase without Acute Kidney Injury in an Adult.

European journal of case reports in internal medicine
2024

Legionella lymphadenitis in immunocompetent adult: Case report.

IDCases
2024

Cutaneous legionellosis in an immunocompromised neonate.

Pediatric dermatology
2024

Capturing Legionella pneumophila effector enzymes using a ubiquitin derived photo-activatable probe.

Frontiers in molecular biosciences
2024

An Atypical Presentation of Legionnaires' Disease.

Cureus
2024

Identification rate of Legionella species in non-purulent sputum culture is comparable to that in purulent sputum culture in Legionella pneumonia.

Journal of clinical microbiology
2024

Inflammatory Patterns Associated with Legionella in HIV and Pneumonia Coinfections.

Pathogens (Basel, Switzerland)
2024

Venovenous extracorporeal membrane oxygenation after cardiac arrest for acute respiratory distress syndrome caused by Legionella: a case report.

Journal of cardiothoracic surgery
2024

Prevention of legionella infections from toilet flushing cisterns.

The Journal of hospital infection
2023

Antibiotic sensitivity of environmental Legionella pneumophila strains isolated in Poland.

Annals of agricultural and environmental medicine : AAEM
2023

Case report: Fatal Legionella infection diagnosed via by metagenomic next-generation sequencing in a patient with chronic myeloid leukemia.

Frontiers in medicine
2025

A rare cause of dysarthria: Legionnaires' disease.

The International journal of neuroscience
2023

A Rare Case of Cold Agglutinin Syndrome Associated With Legionella Pneumonia.

Cureus
2023

Mechanized Pneumonia Secondary to Legionella Infection with Diarrhea as the First Manifestation: a Case Report.

Clinical laboratory
2023

TNF licenses macrophages to undergo rapid caspase-1, -11, and -8-mediated cell death that restricts Legionella pneumophila infection.

PLoS pathogens
2023

Rheumatoid Vasculitis Presenting with Incidental Renal Infarcts: Case Report and Literature Review.

Journal of community hospital internal medicine perspectives
2023

Investigation of a legionellosis outbreak in Sydney CBD - a brief report.

Australian and New Zealand journal of public health
2023

Impact of prolonged hotel closures during the COVID-19 pandemic on Legionella infection risks.

Frontiers in microbiology
2023

Pathogen-defending deubiquitinase possesses distinct specificity towards K6-polyubiquitination.

Trends in microbiology
2023

Atrio-Ventricular Block by Legionella Disease.

Cureus
2023

Diagnosis and Treatment of Water-Contaminated Severe Legionella Pneumonia with Digestive Symptoms as the First Symptom: A Case Report and Review of the Literature.

Infection and drug resistance
2022

Surveillance of Legionella spp. in Open Fountains: Does It Pose a Risk?

Microorganisms
2023

Can legionellosis be considered an occupational risk in the healthcare sector? A systematic review and meta-analysis.

Public health
2023

Inflammasome activation and CCR2-mediated monocyte-derived dendritic cell recruitment restrict Legionella pneumophila infection.

European journal of immunology
2022

Assessment of the risk of Legionella pneumophila in water distribution systems in hospitals of Tehran city.

Environmental monitoring and assessment
2023

Systematic active environmental surveillance successfully identified and controlled the Legionella contamination in the hospital.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
2022

Chromosome-scale assemblies of Acanthamoeba castellanii genomes provide insights into Legionella pneumophila infection-related chromatin reorganization.

Genome research
2022

Tailored approach to study Legionella infection using a lattice light sheet microscope (LLSM).

Biomedical optics express
2022

Legionnaire's Disease Presenting With the Legionella Triad (Pneumonia, Rhabdomyolysis, and Renal Failure) and Cardiac Complications.

Cureus
2022

An application for relating Legionella shower water monitoring results to estimated health outcomes.

Water research
2022

Immensely High Creatine Kinase Levels in a Case of Rhabdomyolysis Due to Legionnaires' Disease in a Patient on Tofacitinib: A Case Report and Literature Review.

Journal of community hospital internal medicine perspectives
2022

Atypical Legionnaires' Disease in the Setting of Suspected Recurrent Lung Cancer.

Cureus
2022

The Triad of Legionnaires' Disease, Rhabdomyolysis, and Acute Kidney Injury: A Case Report.

The American journal of case reports
2022

Acute fibrinous and organizing pneumonia in a patient with Sjögren's syndrome and Legionella pneumonia: a case report and literature review.

BMC pulmonary medicine
2022

Association of Natural Waterways and Legionella pneumophila Infection in Eastern Wisconsin: A Case-Control Study.

Journal of patient-centered research and reviews
2022

Incidence and influence of hyperCKemia in Legionella infection.

Journal of the neurological sciences
2022

Significance of Hypophosphatemia in Patients with Pneumonia.

Internal medicine (Tokyo, Japan)
2022

Effects of Oakmoss Components on Extra- and Intracellular Legionella pneumophila and Its Host Acanthamoeba castellanii.

Biocontrol science
2022

Quantitative Microbial Risk Assessment Applied to Legionella Contamination on Long-Distance Public Transport.

International journal of environmental research and public health
2022

Global Perspective of Legionella Infection in Community-Acquired Pneumonia: A Systematic Review and Meta-Analysis of Observational Studies.

International journal of environmental research and public health
2022

Potential environmental and health risk when returning to normal amidst COVID-19 vaccination.

Current opinion in environmental science &amp; health
2022

Case Report: Community-Acquired Legionella gormanii Pneumonia in an Immunocompetent Patient Detected by Metagenomic Next-Generation Sequencing.

Frontiers in medicine
2022

Immune thrombocytopenic purpura and legionella infection: A case report highlighting the association.

IDCases
2021

Multidisciplinary Management of Legionella Disease in Immunocompromised Patients.

Cureus
2021

Azithromycin-Induced Liver Injury in Legionnaires' Disease.

Cureus
2021

Impact of building closures during the COVID-19 pandemic on Legionella infection risks.

American journal of infection control
2021

Severe bilateral pleuropneumonia caused by Legionella sainthelensi: a case report.

BMC infectious diseases
2021

Acute Myocarditis Associated with Legionella Infection: Usefulness of Layer-specific Two-dimensional Longitudinal Speckle-tracking Analysis.

Journal of cardiovascular echography
2021

Structural and mechanistic basis for protein glutamylation by the kinase fold.

Molecular cell
2021

Serine-ubiquitination regulates Golgi morphology and the secretory pathway upon Legionella infection.

Cell death and differentiation
2021

Early Detection of Legionella pneumophila and Aspergillus by mNGS in a Critically Ill Patient With Legionella Pneumonia After Extracorporeal Membrane Oxygenation Treatment: Case Report and Literature Review.

Frontiers in medicine
2021

The differential diagnosis of pneumonia in two patients infected by atypical pathogens.

Future microbiology
2021

Legionnaires' disease arising with hirsutism: case report of an extremely confusing event.

BMC infectious diseases
2021

Sea water whirlpool spa as a source of Legionella infection.

Journal of water and health
2021

Hospital-acquired Legionella pneumonia outbreak at an academic medical center: Lessons learned.

American journal of infection control
2021

Evidence for multiple cases of recurrent Legionella infection: a Danish national surveillance study.

Thorax
2021

Legionnaires' disease in the time of COVID-19.

Pneumonia (Nathan Qld.)
2020

Persistence of Legionella in Routinely Disinfected Heater-Cooler Units and Heater Units assessed by Propidium Monoazide qPCR.

Pathogens (Basel, Switzerland)
2020

Bacterial OTU deubiquitinases regulate substrate ubiquitination upon Legionella infection.

eLife
2020

Rapid detection of Legionella spp in water samples by ScanVIT method: comparison of acid vs heat treatment.

Annali di igiene : medicina preventiva e di comunita
2020

Sit bath systems: A new source of Legionella infection.

PloS one
2021

Development of ADPribosyl Ubiquitin Analogues to Study Enzymes Involved in Legionella Infection.

Chemistry (Weinheim an der Bergstrasse, Germany)
2021

Legionella Infection during and after the COVID-19 Pandemic.

ACS ES&amp;T water
2020

Legionellosis incidents associated with spa pools, England, 2002-2018.

Public health
2020

Tissue Damage Caused by Impaired Phagocytosis of Dead Cells: A Previously Unrecognized Adverse Effect Contributing to the Pathogenesis of γδ T Cells in Legionella Pneumonia.

ImmunoHorizons
2020

Legionnaires' Disease in Pediatric Patients, Control Measures and 5-Year Follow-up.

The Pediatric infectious disease journal
2020

Prevention and Control of Legionella and Pseudomonas spp. Colonization in Dental Units.

Pathogens (Basel, Switzerland)
2020

Divergent Evolution of Legionella RCC1 Repeat Effectors Defines the Range of Ran GTPase Cycle Targets.

mBio
2020

Distribution of Legionella species and serogroups in patients with culture-confirmed Legionella pneumonia.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
2019

Methylomic Changes of Autophagy-Related Genes by Legionella Effector Lpg2936 in Infected Macrophages.

Frontiers in cell and developmental biology
2019

IL-23 costimulates antigen-specific MAIT cell activation and enables vaccination against bacterial infection.

Science immunology
2020

Regulation of Phosphoribosyl-Linked Serine Ubiquitination by Deubiquitinases DupA and DupB.

Molecular cell
2019

Evaluation and Treatment of Severe Rhabdomyolysis in a Patient with Legionnaires' Disease.

Cureus
2020

Legionnaires' Disease: State of the Art Knowledge of Pathogenesis Mechanisms of Legionella.

Annual review of pathology
2019

The iron-regulated vacuolar Legionella pneumophila MavN protein is a transition-metal transporter.

Proceedings of the National Academy of Sciences of the United States of America
2019

Urinary antigene and PCR can both be used to detect Legionella pneumophila in children's hospital-acquired pneumonia.

European journal of translational myology
2019

Legionella infection associated with dimethyl fumarate used for treatment of multiple sclerosis.

Journal of neurology
2019

Validation of a Prediction Rule for Legionella Pneumonia in Emergency Department Patients.

Open forum infectious diseases
2019

Legionella Pneumonia Following the Heavy Rain Event of July 2018 in Japan.

Internal medicine (Tokyo, Japan)
2019

[An animal experiment regarding the effect of lipopolysaccharide intervention program on Legionella pneumonia].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
2019

Symbiont-Mediated Defense against Legionella pneumophila in Amoebae.

mBio
2019

Potentiation of Cytokine-Mediated Restriction of Legionella Intracellular Replication by a Dot/Icm-Translocated Effector.

Journal of bacteriology
2019

PIKfyve/Fab1 is required for efficient V-ATPase and hydrolase delivery to phagosomes, phagosomal killing, and restriction of Legionella infection.

PLoS pathogens
2019

The Mouse as a Model for Pulmonary Legionella Infection.

Methods in molecular biology (Clifton, N.J.)
2019

The Caenorhabditis elegans Model of Legionella Infection.

Methods in molecular biology (Clifton, N.J.)
2019

Dictyostelium Host Response to Legionella Infection: Strategies and Assays.

Methods in molecular biology (Clifton, N.J.)
2019

Purification and Analysis of Effector Glucosyltransferase Lgt1 from Legionella pneumophila.

Methods in molecular biology (Clifton, N.J.)
2019

Mitochondrial Dynamics and Activity in Legionella-Infected Cells.

Methods in molecular biology (Clifton, N.J.)
2019

Overview and comparison of Legionella regulations worldwide.

American journal of infection control
2018

Data on Legionella prevalence and water quality in showers of retirement homes and group homes in the Province of Rome, Lazio Region, Italy.

Data in brief
2018

Disseminated extrapulmonary Legionella pneumophila infection presenting with panniculitis: case report and literature review.

BMC infectious diseases
2018

Environmental surveillance of Legionella pneumophila in distal water supplies of a hospital for early identification & prevention of hospital-acquired legionellosis.

The Indian journal of medical research
2018

MAIT cells protect against pulmonary Legionella longbeachae infection.

Nature communications
2019

A Systematic In Silico Analysis of the Legionellaceae Family for Identification of Novel Drug Target Candidates.

Microbial drug resistance (Larchmont, N.Y.)
2018

Prevalence of Legionella in retirement homes and group homes water distribution systems.

The Science of the total environment
2018

Acanthamoeba S13WT relies on its bacterial endosymbiont to backpack human pathogenic bacteria and resist Legionella infection on solid media.

Environmental microbiology reports
2018

Acanthamoeba and Dictyostelium as Cellular Models for Legionella Infection.

Frontiers in cellular and infection microbiology
2018

Health risks from exposure to Legionella in reclaimed water aerosols: Toilet flushing, spray irrigation, and cooling towers.

Water research
2017

Differential Effects of Iron, Zinc, and Copper on Dictyostelium discoideum Cell Growth and Resistance to Legionella pneumophila.

Frontiers in cellular and infection microbiology
2018

Legionella pneumonia appeared during hospitalization in a patient with hematological malignancy confirmed by sputum culture after negative urine antigen test.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
2018

Amoebal endosymbiont Neochlamydia protects host amoebae against Legionella pneumophila infection by preventing Legionella entry.

Microbes and infection
2018

MALDI-TOF MS analysis as a useful tool for an identification of Legionella pneumophila, a facultatively pathogenic bacterium interacting with free-living amoebae: A case study from water supply system of hospitals in Bratislava (Slovakia).

Experimental parasitology
2018

May car washing represent a risk for Legionella infection?

Annali di igiene : medicina preventiva e di comunita
2017

Rare presentation of an old bug.

BMJ case reports
2017

Greywater reuse - Assessment of the health risk induced by Legionella pneumophila.

Water research
2018

Differential expression of virulence genes in Legionella pneumophila growing in Acanthamoeba and human monocytes.

Virulence
2017

The Legionella effector WipB is a translocated Ser/Thr phosphatase that targets the host lysosomal nutrient sensing machinery.

Scientific reports
2017

[A Case of Severe Legionella longbeachae Pneumonia and Usefulness of LAMP Assay].

Rinsho Biseibutsu Jinsoku Shindan Kenkyukai shi = JARMAM : Journal of the Association for Rapid Method and Automation in Microbiology
2017

Ubiquitin Chains Modified by the Bacterial Ligase SdeA Are Protected from Deubiquitinase Hydrolysis.

Biochemistry
2017

Legionella Pneumophila and Dendrimers-Mediated Antisense Therapy.

Advanced pharmaceutical bulletin
2017

Occupational risk for Legionella infection among dental healthcare workers: meta-analysis in occupational epidemiology.

BMJ open
2017

Legionnaires' Disease: Clinicoradiological Comparison of Sporadic Versus Outbreak Cases.

Clinical medicine insights. Circulatory, respiratory and pulmonary medicine
2017

Accuracy of diagnostic tests for Legionnaires' disease: a systematic review.

Journal of medical microbiology
2017

Legionella pneumonia associated with severe acute respiratory distress syndrome and diffuse alveolar hemorrhage - A rare association.

Respiratory medicine case reports
2017

Legionnaire's Disease and Influenza.

Infectious disease clinics of North America
2017

A Large Community Outbreak of Legionnaires' Disease Associated With a Cooling Tower in New York City, 2015.

Public health reports (Washington, D.C. : 1974)
2018

Legionnaires' disease at a medical center in southern Taiwan.

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
2017

Innate immunity against Legionella pneumophila during pulmonary infections in mice.

Archives of pharmacal research
2016

A Case of Pulmonary-Renal Syndrome Leading to the Diagnosis of Legionnaires' Disease.

Case reports in nephrology
2017

Legionnaire's Disease and Immunosuppressive Drugs.

Infectious disease clinics of North America
2016

Application of real-time quantitative polymerase chain reaction assay to detect Legionella pneumophila in patients of community-acquired pneumonia in a tertiary care hospital.

Indian journal of medical microbiology
2016

Legionella pneumonia in the Niagara Region, Ontario, Canada: a case series.

Journal of medical case reports
2016

[Overview of emerging and re-emerging infections -the historical transition of infectious diseases-].

Nihon rinsho. Japanese journal of clinical medicine
2017

Successful pediatric ECMO in a rare case of septic shock due to a community-acquired Legionella infection.

Medecine et maladies infectieuses
2016

Clinical Case of the Month: A 64 Year-Old Woman Presenting With Fever, Confusion, Ophthalmoplegia and Pneumonia.

The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society
2016

[Legionnaires' disease complicated by rhabdomyolysis and acute renal failure: about a case].

The Pan African medical journal
2016

Strategies for the reduction of Legionella in biological treatment systems.

Water science and technology : a journal of the International Association on Water Pollution Research
2016

Pulmonary Legionellosis in Oncologic Patients: Findings on Chest CT.

Journal of computer assisted tomography
2016

Community-acquired pneumonia and positive urinary antigen tests: Factors associated with targeted antibiotic therapy.

Medecine et maladies infectieuses
2016

Structural and Functional Investigations of the Effector Protein LpiR1 from Legionella pneumophila.

The Journal of biological chemistry
2016

Combined use of real-time PCR and nested sequence-based typing in survey of human Legionella infection - ERRATUM.

Epidemiology and infection
2016

Complex clinical and microbiological effects on Legionnaires' disease outcone; A retrospective cohort study.

BMC infectious diseases
2016

Combined use of real-time PCR and nested sequence-based typing in survey of human Legionella infection.

Epidemiology and infection
2015

Legionella spp. isolation and quantification from greywater.

MethodsX
2015

Severe Legionnaires' Disease Complicated by Rhabdomyolysis and Clinically Resistant to Moxifloxacin in a Splenectomised Patient: Too Much of a Coincidence?

Case reports in infectious diseases
2015

Diagnostic Utility of Splenial Lesions in a Case of Legionnaires' Disease due to Legionella pneumophila Serogroup 2.

Internal medicine (Tokyo, Japan)
2016

Atypical presentation of Legionella pneumonia among patients with underlying cancer: A fifteen-year review.

The Journal of infection
2015

Legionella Infection in Pregnancy: The Forgotten Pathogen in Septic Shock.

Obstetrics and gynecology
2015

Legionella Pneumophilla Infection Masquerading as Acute Cholecystitis.

Maedica
2015

The occurrence of antibodies against Legionella pneumophila in patients with autoimmune rheumatic diseases.

Polskie Archiwum Medycyny Wewnetrznej
2015

Utility of PCR, Culture, and Antigen Detection Methods for Diagnosis of Legionellosis.

Journal of clinical microbiology
2015

Fatal complication of Legionella pneumophila pneumonia in a tocilizumab-treated rheumatoid arthritis patient.

Internal medicine (Tokyo, Japan)
2015

The Legionella Kinase LegK2 Targets the ARP2/3 Complex To Inhibit Actin Nucleation on Phagosomes and Allow Bacterial Evasion of the Late Endocytic Pathway.

mBio
2015

Characterization of the extent of a large outbreak of Legionnaires' disease by serological assays.

BMC infectious diseases
2015

[The clinical value of urinary antigen detection of Legionella pneumonia].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
2015

Post-translational modifications are key players of the Legionella pneumophila infection strategy.

Frontiers in microbiology
2015

Interleukin-17A in Legionella pneumonia: a retrospective study.

Japanese journal of infectious diseases

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Doenças relacionadas

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Fulminant Rhabdomyolysis and Acute Kidney Injury Associated With Pontiac Fever: A Case Report.
    Cureus· 2026· PMID 41835684mais citado
  2. Frequency of rhabdomyolysis in Legionella infection and associated outcomes: a retrospective cross-sectional study.
    Postgraduate medicine· 2026· PMID 41714923mais citado
  3. Diagnostic methods and therapeutics strategies of Legionella infection in postbone marrow transplantation.
    Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences· 2025· PMID 40980483mais citado
  4. A rare cause of dysarthria: Legionnaires' disease.
    The International journal of neuroscience· 2025· PMID 38060476mais citado
  5. A Case of Legionella Pneumonia Suspected as Typical Pneumonia After Lung Cancer Surgery, Diagnosed by a Repeat Urinary Legionella Antigen Test.
    Cureus· 2025· PMID 41341339mais citado
  6. Case Report: Cavitary Legionella pneumophila pneumonia in a kidney transplant recipient: mNGS-guided diagnosis and prolonged combination therapy.
    Front Med (Lausanne)· 2026· PMID 41907295recente
  7. Structural insights into SetA-mediated Rab1 glucosylation and PI3P-guided localization during early Legionella infection.
    Proc Natl Acad Sci U S A· 2026· PMID 41894332recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:600832(Orphanet)
  2. MONDO:0005823(MONDO)
  3. GARD:22419(GARD (NIH))
  4. Busca completa no PubMed(PubMed)
  5. Artigo Wikipedia(Wikipedia)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

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