Infecção na córnea causada pela acanthamoeba; geralmente está associada ao uso de lentes de contato gelatinosas, principalmente quando usadas para dormir.
Introdução
O que você precisa saber de cara
Infecção na córnea causada pela acanthamoeba; geralmente está associada ao uso de lentes de contato gelatinosas, principalmente quando usadas para dormir.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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O que aparece no corpo e com que frequência cada sintoma acontece
Características mais comuns
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Nenhum gene associado encontrado
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Os sinais que médicos procuram e os exames que confirmam
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🇧🇷 Atendimento SUS — Ceratite por Acanthamoeba
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Publicações mais relevantes
Detection of free-living amoebae and Stenotrophomonas maltophilia in two drinking water networks in eastern Pennsylvania.
The presence of free-living amoebae (FLA) in drinking water systems, along with the pathogens they harbor, is a global concern. Free-living amoebae are ubiquitous microorganisms found in both natural and man-made environments. Some FLA can cause fatal infections such as primary amoebic meningoencephalitis (PAM) and amoebic keratitis (AK). Additionally, certain FLA may harbor pathogenic bacteria and play a role in their fate and transport. In this study, we investigated the presence of FLA and the endosymbiotic opportunistic pathogen Stenotrophomonas maltophilia in drinking water delivery networks. Known for its multi-drug resistance, S. maltophilia has been associated with infections in immunocompromised people, especially those in hospitals. From January 2022 to December 2023, raw and finished water samples were collected approximately monthly from two Pennsylvania water utilities. Free-living amoebae were detected by filtration and plating. Results showed 74 % (56/76) of all raw water samples, and 22 % (15/69) and 14 % (12/83) of finished water samples from the two utilities, respectively, were positive for FLA by microscopy. Confirmatory testing using DNA extraction, PCR, and Sanger sequencing showed that 47 % (36/76) of all raw water samples, and 20 % (14/69) and 14 % (12/83) of finished water samples from the two utilities, respectively, were positive for at least one of the targeted FLA. Vermamoeba vermiformis was the most frequently recovered FLA, followed by Acanthamoeba spp. Potentially endosymbiotic S. maltophilia was recovered at various locations throughout the water treatment plants and the distribution system, demonstrating that FLA can serve as vectors that transport bacteria through conventional water treatment processes.
The Role of in Vivo Confocal Microscopy in Diagnosing and Managing Infectious Keratitis in Deployed French Military Personnel: A Case Series.
Fungal and amoebic keratitis are rare but serious infections that can lead to significant vision loss and are often difficult to diagnose promptly, particularly in resource-limited environments. Although conventional cultures and PCR have notable diagnostic limitations, in vivo confocal microscopy (IVCM) offers rapid and accurate pathogen detection. This retrospective case series examines four cases of infectious keratitis in deployed military personnel, highlighting the diagnostic and clinical utility of IVCM. All patients were young males, with a mean age of 29.75 years. Half had a history of improper contact lens use, although the others sustained ocular trauma from plant material. Corneal cultures performed in the field were uniformly negative, underscoring the limitations of traditional diagnostics in austere settings. In contrast, IVCM performed after the patients were repatriated enabled timely identification of filamentous fungi and amoebic cysts, allowing for targeted antimicrobial therapy. Patients experienced prolonged hospitalizations (mean: 2 months) and extended treatment courses (up to 9 months), with three undergoing amniotic membrane transplantation. Early diagnosis using IVCM contributed to the prevention of severe complications such as corneal perforation and endophthalmitis. These findings support the role of IVCM as a critical diagnostic modality in managing complex corneal infections when conventional microbiological tools are unavailable or insufficient.
Genotyping of Acanthamoeba From Different Wards of Gonabad Bohlool Hospital, Northeastern Iran.
Background: Acanthamoeba is a free-living amoeba that is widely found in nature in different environments such as soil, water, and dust. This parasite is the cause of amoebic keratitis and granulomatous amoebic encephalitis. This study is aimed at investigating the prevalence and genotypes of Acanthamoeba in different wards of Gonabad Bohlool Hospital, northeastern Iran. Methods: One hundred and eighty-three samples were collected from equipment in various wards of Gonabad hospital in 2023; swabs were cultured in nonnutrient agar (NNA) medium with the addition of killed Escherichia coli. In positive samples containing stellate cysts, PCR molecular testing was performed using JDP1 and JDP2 primers. To confirm Acanthamoeba, genotyping and sequencing were also done. Results: Acanthamoeba sp. was observed in 114 out of 183 samples (62.30%). The highest percentage of Acanthamoeba contamination was in the emergency ward with 81.82%, and the lowest percentage was in the operating and imaging room with 50%. Moreover, the highest percentage of Acanthamoeba contamination was in staff areas and equipment with 66.67%, and the lowest percentage was 56.14% on medical equipment. Also, in this research, the Genotypes T4 (n = 10, 43.5%), T3 (n = 4, 17.4%), T5 (n = 4, 17.4%), T11 (n = 3, 13%), and T2 (n = 2, 8.7%) were determined. Conclusions: The findings of this study showed that Acanthamoeba is more common in the emergency ward and on the surfaces and equipment of the staff areas. Considering the dangerous complications caused by this amoeba, health education to increase awareness in the field of transmission as well as health measures to prevent contamination, including disinfection, is recommended.
Evaluation of the potential for diagnosis of fungal keratitis using a Fusarium-specific antibody.
The increasing number of contact lens users correlates with a rise in the incidence of fungal keratitis. Fungal keratitis can lead to blindness if not treated promptly, and its early symptoms are similar to those of bacterial and amoebic keratitis, making rapid diagnosis challenging. This study aimed to assess the potential of using a peptide antibody against the fungal-specific protein ERG24, which encodes sterol C-14 reductase, to differentiate fungal keratitis from other forms of keratitis. The specificity of the ERG24 antibody was assessed through Western blot and enzyme-linked immunosorbent assay (ELISA). Immunocytochemistry (ICC) was performed by co-culturing two types of fungi, Acanthamoeba, and two bacterial strains with human corneal epithelial (HCE) cells. Additionally, to evaluate the diagnostic potential of the ERG24 antibody, animal models of fungal, amoebic, and bacterial keratitis were developed, and ELISA was conducted on tear and ocular lysates from these models. The results demonstrated that the antibody specifically reacted with Fusarium solani in Western blot, and both ELISA and ICC confirmed that the ERG24 antibody did not react with HCE cells, Acanthamoeba, or bacteria, but was specific to the two fungal species. In vivo experiments further showed that the ERG24 antibody significantly detected F. solani in tear-wash samples and eyeball lysates from the fungal keratitis model, without reacting with samples from amoebic and bacterial keratitis models. This study suggests that the ERG24 peptide antibody could provide valuable information for developing differential diagnostic methods for fungal keratitis compared to other forms of keratitis.
Encystment and Excystment Processes in Acanthamoeba castellanii: An Emphasis on Cellulose Involvement.
The free-living amoeba Acanthamoeba castellanii is a unicellular eukaryote distributed in a wide range of soil or aquatic environments, either natural or human-made, such as rivers, lakes, drinking water, or swimming pools. Besides its capacity to transport potential pathogens, such as bacteria or viruses, Acanthamoeba spp. can have intrinsic pathogenic properties by causing severe infections at the ocular and cerebral level, named granulomatous amoebic encephalitis and amoebic keratitis, respectively. During its life cycle, A. castellanii alternates between a vegetative and mobile form, named the trophozoite, and a resistant, latent, and non-mobile form, named the cyst. The cyst wall of Acanthamoeba is double-layered, with an inner endocyst and an outer ectocyst, and is mainly composed of cellulose and proteins. The resistance of cysts to many environmental stresses and disinfection treatments has been assigned to the presence of cellulose. The current review aims to present the importance of this glycopolymer in Acanthamoeba cysts and to further report the pathways involved in encystment and excystment.
Publicações recentes
Targeted Identification of Acanthamoeba in Clinical Corneal Specimens Using a Monoclonal Antibody: Proof of Concept for a New Diagnostic Tool.
Detection of free-living amoebae and Stenotrophomonas maltophilia in two drinking water networks in eastern Pennsylvania.
The Role of in Vivo Confocal Microscopy in Diagnosing and Managing Infectious Keratitis in Deployed French Military Personnel: A Case Series.
Genotyping of Acanthamoeba From Different Wards of Gonabad Bohlool Hospital, Northeastern Iran.
Evaluation of the potential for diagnosis of fungal keratitis using a Fusarium-specific antibody.
📚 EuropePMC27 artigos no totalmostrando 81
Detection of free-living amoebae and Stenotrophomonas maltophilia in two drinking water networks in eastern Pennsylvania.
International journal of hygiene and environmental healthThe Role of in Vivo Confocal Microscopy in Diagnosing and Managing Infectious Keratitis in Deployed French Military Personnel: A Case Series.
Military medicineGenotyping of Acanthamoeba From Different Wards of Gonabad Bohlool Hospital, Northeastern Iran.
International journal of microbiologyEvaluation of the potential for diagnosis of fungal keratitis using a Fusarium-specific antibody.
Scientific reportsEncystment and Excystment Processes in Acanthamoeba castellanii: An Emphasis on Cellulose Involvement.
Pathogens (Basel, Switzerland)Detection and co-occurrence of Acanthamoeba and Klebsiella pneumoniae in freshwater river systems of Taichung, Taiwan.
BMC microbiologyEstablishing a Cre/loxP-based genetic manipulation system for Acanthamoeba: Targeted genome editing and stable reporter expression.
Parasites, hosts and diseasesCombating the causative agent of amoebic keratitis, Acanthamoeba castellanii, using Padina pavonica alcoholic extract: toxicokinetic and molecular docking approaches.
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Detection of free-living amoebae and Stenotrophomonas maltophilia in two drinking water networks in eastern Pennsylvania.
- The Role of in Vivo Confocal Microscopy in Diagnosing and Managing Infectious Keratitis in Deployed French Military Personnel: A Case Series.
- Genotyping of Acanthamoeba From Different Wards of Gonabad Bohlool Hospital, Northeastern Iran.
- Evaluation of the potential for diagnosis of fungal keratitis using a Fusarium-specific antibody.
- Encystment and Excystment Processes in Acanthamoeba castellanii: An Emphasis on Cellulose Involvement.
- Targeted Identification of Acanthamoeba in Clinical Corneal Specimens Using a Monoclonal Antibody: Proof of Concept for a New Diagnostic Tool.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:67043(Orphanet)
- MONDO:0005629(MONDO)
- GARD:9285(GARD (NIH))
- Busca completa no PubMed(PubMed)
- Q922971(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
