Tyrosine Hydroxylase Deficiency Impairs TH Axonal Transport, Brain Function, and Neuronal Plasticity.

Pharmacokinetics and Bioequivalence of 2 Deutetrabenazine Tablets in Healthy Chinese Volunteers Under Fasting and Fed Conditions.

Synchronous activation of striatal cholinergic interneurons induces local serotonin release.

Targeting Dopaminergic Pathways: Current and Emerging Dopamine Inhibitors in Neurological and Psychiatric Disorders.

Pregnanolone Glutamate: A Dual-Fate Delivery System for Neuroactive Steroids in Perinatal Focal Cerebral Ischemia.

Deletion of TRPA1 Ion Channel Modulates the Central Stress Responses in a Mouse Model of Posttraumatic Stress Disorder.

Clavulanic Acid Attenuated Cocaine Craving in Individuals with Cocaine Use Disorder.

Treatment gaps in guideline-directed medical therapy for HFrEF in Singapore: findings from a multicentre retrospective cohort study.

[Protective effects of Suanzaoren Decoction on hippocampal neuron and its influence on PI3K/Akt signaling pathway in APP/PS1 transgenic mice].

Neuroprotective Effects of Esketamine in Central Nervous System Disorders: Mechanisms and Cellular Targets.

Zolpidem restores sleep and decreases amyloid in a mouse model.

Glycine receptors in circulating white blood cells regulated by neuroinflammation.

HSDL2 Suppresses Epileptic Seizures Through Phosphorylation-Dependent Modulation of the PSD95-NMDAR Signaling Axis.

VGLUT1 and PSD-95 Expression Remains Stable in the Prefrontal and Cerebellar Cortices of the VPA Autism Rat Model.

Impact of risperidone and voluntary exercise on ketone body metabolism-related gene expression in the brain of female juvenile rats.

Advances in calcium signalling research for the diagnosis and treatment of depression.

N6-adenosine methylation enhances nuclear mRNA export through METTL3 and NUP93.

Loss of function of the chromatin remodeling gene INO80D leads to neurogenic features of schizophrenia.

Fear extinction induces maladaptive generalization via noradrenergic and GABAergic systems.

Computational modeling for rational design of novel phenoxy tacrine derivatives targeting Alzheimer's disease.

Crocin Mitigates Glutamate Excitotoxicity and Tau Hyperphosphorylation by Modulating EAAT2 and Akt/Tau Pathway in a Scopolamine-induced Rat Model of Alzheimer's Disease.

Neurofilament light chain protein exposure contributes to protein aggregation, microgliosis, astrogliosis and neuroinflammation via p38/MK2/NF-κB/CREB1/Nrf2/HO-1 signalling leading to Parkinson's disease.

MCC-135 Exerts Antiepileptic and Neuroprotective Effects by Downregulating NCX1 Expression to Decrease Intracellular Calcium Overload in the Hippocampus.

Early administration of a low dose of memantine prevents neurological symptoms, neuronal loss and attenuates infarct size in a rat stroke model.

Hypocretin receptor 1 blockade early in abstinence reduces future demand for cocaine.

The pharmacokinetics of tolfenamic acid in Himalayan Griffon vultures. A better understanding for the safety of the drug in old world vultures.

Structure-activity relationships of steroid and sterol neuromodulators on inflammatory markers in a murine microglial cell line.

Development of a MS binding assay to analyze the interactions of drugs with the ifenprodil binding site of NMDA receptors with GluN2B subunit.

NMDA receptor antagonism requires serotonin and noradrenaline to induce antidepressant-like effects in a treatment-resistant depression rat model.

Nitric Oxide Synthase Dysregulation in Hyperammonemia: Opportunities and Challenges Toward Therapeutic Targeting to Combat Neurological Complications.

Electroacupuncture Facilitates the Regulation of Inflammation in the Conjunctiva of Rabbits With Dry Eye Syndrome via the α7nAChR-HMGB1 Signaling Pathway.

Exploring the neurofunctional potential of saffron bioactives: from mood-related behavioral modulation to brain access of safranal.

Chronic Histamine Exposure Promotes Melanogenesis via ORAI1-STIM1-Mediated Calcium Signaling Remodeling.

Dynamics of hidden brain states in post-stroke cognitive impairment: Linking neural activity to neurotransmitter systems and genetic pathways.

Sensory neuron production of substance P and TAFA4 promotes disease tolerance during viral infection.

Membrane Dysfunction as a Central Mechanism in LRRK2-Associated Parkinson's Disease: Comparative Analysis of G2019S and I1371V Variants.

The β-amyloid-induced increased tonic conductance, impaired long-term potentiation and cognitive deficits characteristic of Alzheimer's disease are reversed by an α5 inverse agonist of the GABA type A receptor.

Subunit-specific roles of LRRC8 proteins in determining glutamate permeability of astrocytic volume-regulated anion channels.

Characterization of cardiac disease-associated mutations in RyR2 Ca2+- and caffeine-binding sites.

Pharmacogenomics of risperidone in autism spectrum disorder: a minireview.

Nicotinic acetylcholine receptors-targeting drug discovery.

Investigation into the antidepressant mechanism of the Guizhi-Baishao herbal pair based on network pharmacology and molecular docking.

The ketogenic diet alters microbiome-metabolome profiles to improve West syndrome therapy.

Myoglobin in disease: the good and the bad.

Alterations in the jejunal 5-hydroxytryptamine synthesis and turnover in septic mice induced by cecal ligation and puncture.

Transcranial Photobiomodulation Modulates Oxidative Stress Biomarkers and Complex IV Activity in Anhedonic-Like Behavior.

Effect of 6-Hydroxydopamine on Iron Metabolism in MO3.13 Oligodendrocytes.

Vortioxetine: A comprehensive profile.

Novel positive allosteric modulators of alpha 5 subunit-containing GABAA receptors (α5-GABAARs) reverse the hyperdopaminergic state in a neurodevelopmental model of schizophrenia.

Access to novel potent pleiotropic prodrugs, targeting both butyrylcholinesterase and serotonin reuptake, with anti-amnesic activities in Alzheimer's disease model.

Alpha-methyl-para-tyrosine and amphetamine ameliorate hyperactivity in a novel mouse model of dopamine transporter deficiency syndrome.

S-nitrosylation of Dexras1 attenuates fear memory generalization in the infralimbic cortex.

L-type voltage-dependent calcium channels in the ventromedial orbitofrontal and prefrontal cortices mediate the inhibitory effects of (S)-ketamine but not (R)-ketamine on marble burying in male mice.

The impact of predator stress on electroshock seizure threshold: insights into GABAergic, glutamatergic, and serotonergic pathways in mice.

Placental iron transport under maternal stress: a missing link in foetal programming and mental health.

Sex differences in AMPA receptor trafficking proteins.

Rhubarb enhances gastrointestinal motility via calcium-mediated intestinal acetylcholine release: a network pharmacology study.

MC-350013 and Corylin Emerge as Promising Neuroprotective Agents through Dual Targeting of xCT and GLT-1.

Elevated Na+/K+ Ratio in Alzheimer's Disease: A Potential Biomarker for Braak Stage.

De Novo Generation-Based Design of Potential Computational Hits Targeting the GluN1-GluN2A Receptor.

Serotonin, Kynurenine, and Indole Pathways of Tryptophan Metabolism in Humans in Health and Disease.

Synaptogyrin-3 plays a critical role in addiction-related dopamine dysfunction and behavioral maladaptations.

Stathmin 1 regulates epileptic seizures by influencing GABAA R-mediated inhibitory synaptic activity.

Echinoderm collagen as a neuromodulatory antioxidant: biochemical characterization and molecular interaction with NMDA receptor.

P2X7 receptors as targets for neuroprotection.

Both DLCO and KCO are vital indices in assessment of diffusing capacity for carbon monoxide by the single-breath method.

VMAT2 dysfunction impairs vesicular dopamine uptake, driving its oxidation and α-synuclein pathology in DJ-1-linked Parkinson's neurons.

Investigating the anti-Alzheimer potential of biogenic compounds from Zinc15 database as NMDA antagonist: An in-silico approach.

Signal-Level Determinants of Cognitive Decline With PPIs versus H2RAs: Transportome (CBLIF/TCN2) and CHRNA7 Nodes.

Regional correlates of tau pathology and synaptic function in primary age-related tauopathy.

Validates blood pressure control for seizure management: Jujuboside B exerts antiseizure effects via blood pressure reduction and activation of NTS-VGLUT2+ neurons.

An emerging role for synaptic Zn2+ in substance use disorders.

ABCA7 deficiency exacerbates glutamate excitotoxicity in Alzheimer's disease mice - A new pharmacological target for Glu-related neurotoxicity.

Altered serotonergic system and mood behaviors in a cuprizone-induced model of demyelination.

Heterogeneity-Aware, Multiscale Annotation of Shared and Specific Neurobiological Signatures among Major Neurodevelopmental Disorders.

Distinct allosteric paths mediate a Ca2+-dependent increase in NMDA receptor sensitivity to open-channel blockers.

Aniracetam restores the excitation-inhibition balance of neurotransmitters in the prefrontal cortex of mice with ADHD.

Multicolor Quantum Dot Tracking Uncovers Phenotypic Rescue of DAT A559V Aberrant Diffusion Upon D2R Antagonism.

Plasma KCC2, NKCC1, and GABA as peripheral biomarkers in autism spectrum disorder: a combined ROC analysis.

Dose-Dependent Neurobehavioral and Molecular Responses to Diclofenac in Zebrafish Larvae.

Unravelling GABA Dysfunction in Autism: Pathophysiological Insights and Emerging Treatments.

Are glutathionylated aldehyde reductases the missing piece of the "catecholaldehyde hypothesis" in Parkinson's disease? A medical hypothesis concerning the detoxification of 4-hydroxynonenal (HNE) and 3,4-dihydroxyphenylacetaldehyde (DOPAL).

Acute effects of selective serotonin reuptake inhibitors on cerebral glucose metabolism and blood flow.

Micro pharmacokinetics-pharmacodynamics monitoring of anti-Parkinson's disease drugs using a microphysiological BBB-brain organ-on-a-chip.

Prenatal Stress and Prenatal Alcohol Alter the Adult Dopamine System and Alcohol Consumption: Dopamine Drives Drinking Behavior in a Prospective 20-Year Longitudinal Experiment with Rhesus Macaques.

Neuropeptide S Protects Dopaminergic Neurons in a Paraquat-Induced Parkinson's Model Using SH-SY5Y Cells.

TrkB receptor antagonist ANA-12 impairs memory reconsolidation in novel object recognition task via regulation of hippocampal transcriptome.

Pharmacological activity of a new ligand binding at the histamine site of the NMDA receptor in rodents.

Brilliant blue G enhances cardiac function and suppresses ventricular arrhythmias by attenuating inflammation and fibrosis after post-myocardial infarction in rats.

Structural basis for selective inhibition of human GABA transporter GAT3.

Impaired adrenergic regulation of Kv channels underlies LC hyperactivity and early-onset sleep disruption in AD-like amyloidogenic mice.

Selective RyR2 inhibition reduces arrhythmia susceptibility in human cardiac slices.

α-Synuclein expression is required for somatodendritic dopamine release and immediate early gene induction.

A Nonketotic Hyperglycinemia Mouse Shows Wide-Ranging Biochemical Consequences of Elevated Glycine, Reduced Folate One-Carbon Charging, and Serine Deficiency.

Efficacy and Mechanism of Synbiotics in Relieving Functional Constipation: Optimized by Generation Time.

Exploring purinergic and inflammatory pathways in bipolar disorder: evidence for diagnostic utility of UA, IL-6, NACHT, P2X7, ADA, XDH, ADO.

Mouse model of atypical DAT deficiency syndrome uncovers dopamine dysfunction associated with parkinsonism and ADHD.

Presynaptic Terminal Proteins and Nicotinic Receptors Are Depleted from Mouse Parasympathetic Ganglionic Junctions Paralysed with Botulinum Neurotoxin Type A.

Hippocampal Metabolomics Reveal the Mechanism of α-Conotoxin [S9K]TxID Attenuating Nicotine Addiction.

Diosmin Alleviates Pain via Mechanisms Involving Acetylcholinesterase and TRPV1 Inhibition: An In Silico and In Vivo Study.

Osmotin-derived 9-amino-acid peptide alleviates α-synuclein and MPTP-induced glial cell activation mediated neuroinflammation, protecting dopaminergic neurons in Parkinson's disease mice brain.

Nicotine Regulates LPS-Induced Inflammatory Responses in HMC3 Microglia and Exerts Neuronal Protection.

Calretinin Contributes to Trigeminal Neuropathic Pain Downstream of Cavα2δ1.

"Summertime sadness": Striatal dopamine binding decreases during warmer seasons in patients with severe depression.

40 Hz flicker preconditioning protects nonarteritic anterior ischemic optic neuropathy via adenosine signaling.

Modulating tonic NMDA receptor currents: mechanistic insights into ketamine, esketamine, and dextromethorphan for major depressive disorder and implications for the discovery and development of investigational agents.

METTL16-m6A-PGC-1α axis contributes to exercise-induced mitochondrial adaptations in skeletal muscle of high-fat diet-fed insulin-resistant mice.

Cognitive enhancing effect of Canagliflozin in aluminum-induced rat model of Alzheimer's-like disease: Cross-talk between Amyloid-Β and BDNF/GSK-3β signaling.

Involvement of α7 nicotinic acetylcholine receptor-signaling in social behavior impairments in the stressed mice.

Subgenual anterior cingulate cortex and antidepressant response to serotonergic and glutamatergic pharmacological treatments: a systematic review of neuroimaging studies.

ATP-binding cassette transporter polymorphisms and the pharmacokinetics of oral esketamine.

Hydrogen sulphide as a potential contributer to cardiovascular protection with sodium-glucose cotransporter 2 inhibition.

Circadian Regulation of m6A RNA Methylation in Migraine: Mechanisms and Therapeutic Implications.

Monocolonization with Bacteroides thetaiotaomicron exerts region-specific effects on Alzheimer's disease-related traits in the murine brain.

Neurochemical and behavioral evidence of high abuse liability of 3F-NEB, a novel synthetic cathinone.

WGS analysis and functional studies illustrate promising gene-signatures for probiotic attributes and molecular-targeted therapeutic prospects of Lactiplantibacillus plantarum LP-ARP2.

VGLUT2 in Parkinson's disease: an emerging therapeutic target.

METTL3-mediated m6A modification of CACNA1E promotes osteosarcoma progression and chemoresistance by enhancing WNT7B-mediated Ca2+ signaling.

Intrinsic connectivity patterns of striatal subfields predict individual dimensions of psychopathology and are associated with cholinergic and serotonergic neurotransmission in schizophrenia.

Negr1 deficiency alters glutamate signalling and kynurenine pathway in a mouse model of psychiatric disorders.

GABAergic dynamics in thalamocortical circuits: Insights into absence seizures and hyperinhibition.

Exploring a genetic basis for the metabolic perturbations in ME/CFS using UK biobank.

Synaptic effects of interleukin-6 on human iPSC-derived dopaminergic neurons.

Astrocytic FKBP5 regulates neuroinflammation and cognitive outcomes in male mouse models of excitotoxic epilepsy.

Mitochondrial DNA 6 mA methylation by METTL4 drives neuroinflammation via cGAS-STING activation in vascular cognitive impairment.

Sinapic acid balances the excitatory and inhibitory neurotransmitter systems to mitigate post-traumatic stress disorder-like behaviors.

L-Quebrachitol Enhances Sedative Effect of Diazepam Through GABAergic Pathway: Animal and Computational Studies.

Focus on the excitatory and inhibitory neurotransmission imbalance in amyotrophic lateral sclerosis: a harmful disease player or a potential therapeutic opportunity?

Fluorescence-based assay for rapid screening of GABAA receptor modulating steroid antagonists (GAMSA).

Anatabine: a substitute for the medicinal activity of nicotine.

Clonidine compromises human sperm functions.

Disruption of the Placenta-Brain Axis in Transgenic Mice Lacking Serotonin Transporter (SERT) in Trophoblast Cells.

Neuromodulatory Effects of Arecoline on Anxiety-like Behavior in Mice Exposed to Chronic Unpredictable Mild Stress.

Transient receptor potential channels as emerging therapeutic targets: mechanisms and therapeutic insights in inflammatory bowel disease.

Minocycline-induced microglial remodeling restores hippocampal NMDA-dependent synaptic plasticity and reduces anxiety-like behavior in juvenile rats with temporal lobe epileptogenesis.

The role of zinc homeostasis in major depressive disorder: heterogeneous pathological mechanisms and therapeutic implications.

The Selective Bromodomain and Extra-Terminal Domain (BET) Inhibitor RVX-208 Reduces Cocaine-Seeking Behaviour and Alters Proteomic Pathways in the Nucleus Accumbens.

Elevated serotonin receptor 2A signaling restores learning and memory in a Fragile X syndrome model.

Lumacaftor and fexofenadine prevent donepezil-induced LQTS via PHE656-mediated hERG chaperoning.

Development of a Novel Benzodiazepine to Delineate Peripheral GABA-A Signaling Mechanisms in Visceral Pain Syndromes.

A mouse model of a patient derived P544L mutation in the Slc6a8 gene shows hypoactivity and cognitive deficits.

Ultramicronized palmitoylethanolamide restores astrocyte-neuron metabolic coupling and Klotho/FGF21 signaling in a triple-transgenic mouse model of Alzheimer's disease.

Novel drug candidate binds to delta subunit containing GABAA receptors and improves spatial memory.

Immature Caenorhabditis elegans motor neurons control early embryo behavior via both synaptic and nonsynaptic GABA release.

Inhibition of CaV1.4 channels by CaV3 channel antagonists ML218 and Z944.

Placental serotonergic system dysregulation is associated with early impairments in infant neurodevelopment.

Bushen Huoxue recipe regulates endometrial epithelial ion channels to promote embryo implantation in controlled ovarian hyperstimulation mice.

Effects of Kamikihito on the Noradrenergic System and Its Pharmacokinetic Profile.

Plasma supplemented with glycine is superior to standard plasma in reducing vascular permeability and organ injury via reduction of inflammation in an experimental traumatic shock model.

Computational Based Identified EAAT2 Transporter Activator Attenuates Amyloid-β Induced Excitotoxicity in Primary Neuronal-Astroglial Mixed Culture by Ameliorating Glutamate Clearance.

CHRNA5 D398N mutation in addiction: Pathogenic insights and therapeutic discovery.

Memantine Confers Multi-Target Protection in a Zebrafish Seizure Model: Attenuating Epileptic Behavior, GluN2A Overexpression, and Oxidative Stress.

Cx43 phosphorylation at Ser368 facilitates PASMC dedifferentiation in nicotine-induced pulmonary arterial remodeling.

Early P2X7 receptor activation mitigates neonatal group B Streptococcus infection severity and long-term neurodevelopmental impairment.

Anti-arrhythmic targeting of sympathetic stellate ganglion P2X3 receptors.

Functional Variation in RGS12 Should Not Preclude Methylphenidate Use in Bipolar Disorder with Established Mood Stabilization: Preclinical Evidence.

LPS-Induced Neuroinflammation Increases Serotonin-Evoked Activity of Trigeminal Afferents and Aggravates Mechanical Allodynia and Photophobic Behavior in Rat Migraine Model.

Indole compounds produced by gut microbiota after metabolizing tryptophan improve dysmotility in sepsis via the AHR-TRPA1 axis in enteric nerves.

Canagliflozin restores electrical properties and suppresses structural damage in isoproterenol-induced myocardial injury models.

Dopamine and serotonin neurotransmissions exert complementary control over primate approach and avoidance.

Transglutaminase-2 Promotes Microglial Synaptic Phagocytosis and Ameliorates Epileptic Seizures by Inhibiting ABCA1 Ubiquitination.

Cerebralcare Granule® restores intracranial lymphatic drainage system to support proactive brain health in Alzheimer's disease models.

High-fat diet disrupts a septal control on feeding to promote obesity in male mice.

Synuclein and Mitochondrial Dysfunction: Regulating the Protein Import Complex toward PD Treatment?

The Increased Activity of CaV3.2 Channels Contributes to Nociceptors' Hyperexcitability and Chronic Neuropathic Pain Following Spinal Cord Injury in Mice.

APOE4 reduces hippocampal expression of phosphoglycerate kinase 1 and sodium potassium pump to enhance seizure susceptibility in mice.

The striatal heterogeneous nuclear ribonucleoprotein H1 mRNA targetome associated with methamphetamine administration and behavior.

Paeony root prevents 6-hydroxydopamine-induced neurotoxicity by regulating autophagic dysfunction via AKT signaling in Parkinson's disease models.

Deciphering Ibogaine's Matrix Pharmacology: Multiple Transporter Modulation at Serotonin Synapses.

Gestational physical exercise prevents early-life behavioral impairments in the offspring of a rat model of attention deficit hyperactivity disorder.

Prolonged exposure of cerebrocortical neurons to diazepam induces downregulation of surface α1-containing GABAA receptors and uncoupling of GABA/benzodiazepine site interactions through different mechanisms.

Teneurin-4 knockdown disrupts dopamine dynamics and attenuates methamphetamine-induced behaviors.

Astrocytic GABA controls fidelity of temporal cortical processing in Fragile X Syndrome.

SLC38A3 deficiency reveals a critical role of blood-derived glutamine in brain development.

Characterizing Spatial Associations Between GluCEST MRI and Neurotransmitter Receptor Density in the Human Cortex.

CGRP alleviates epilepsy via JAK1-STAT1-P2RX7 signaling: a novel neuroprotective axis targeting neuronal damage.

Epithelial ion transport in spring-lengthened jejunum in a porcine model.

HCN channel inhibitor ZD7288 in the lateral septum attenuates methamphetamine-induced behavior sensitization and relapse.

AR-R17779, an agonist of alpha-7 nicotinic acetylcholine receptor, attenuates trauma-induced lung epithelial glycocalyx injury by suppressing macrophage proinflammatory activity.

Enhancing Remyelination by Blockade of Astrocytic P2X1 Receptors Signaling in Cuprizone-Induced Demyelination Mouse Model.

Kynurenic acid signaling expands in human and nonhuman primates and impairs dorsolateral prefrontal cortical cognition that is key to mental illness.

Placenta-derived extracellular vesicles in fetal health: emerging insights into brain development and environmental interactions.

Frankincense-loaded lactoferrin-conjugated solid lipid nanoparticles for targeted brain delivery and neuroprotection in a scopolamine-induced Alzheimer's model.

METTL3-m6A-SLC25A11 Axis Promotes Chronic Hypoxia-Induced Cardiomyocyte Ferroptosis.

Isodrimenine Derivatives Selectively Inhibit Human α7-Containing Nicotinic Acetylcholine Receptors via Negative Allosteric Modulation.

GABAergic synapses between auditory efferent neurons and type II spiral ganglion afferent neurons in the mouse cochlea.

TNF-α signaling mediates the dopaminergic effects of methamphetamine by stimulating dopamine transporters and L-type Ca2+ channels.

Neurotoxicity and Potential Mechanisms of Exposure to Per- and Polyfluoroalkyl Substances (PFASs).

Valproic Acid-Induced Autistic-Like Behavior Is Accompanied by Intestinal Damage Driving Changes in Gut Permeability in a Sex-Dependent Way in Rats.

Structural basis for pharmacotherapeutic action of triple reuptake inhibitors.

Time-specific perturbation of the serotonergic system differentially modulates the transcriptional landscape of hippocampal subregions in female rats.

Evaluating the adenosine hypothesis of restless legs syndrome and its implications for current and future treatment strategies.

A co-culture model of dopaminergic and glutamatergic neurons derived from patients with idiopathic schizophrenia reveals a hypodopaminergic phenotype.

Optogenetic regulation of chloride ions in reactive astrocytes may mitigate Parkinson's disease pathology.

Investigating the Potential Roles of Environmental Exposures on the Pathology of Amyotrophic Lateral Sclerosis by Overlap Analysis.

[Potential biological mechanisms underlying spaceflight-induced depression symptoms in astronauts].

Sodium butyrate-induced autophagy in colorectal cancer unveils the Ca²⁺/CaMKKβ signaling pathway as a potential therapeutic target.

Loss of presenilin 2 function age-dependently increases susceptibility to kainate-induced acute seizures and blunts hippocampal kainate-type glutamate receptor expression.

The Fluidic Connectome in Brain Disease: Integrating Aquaporin-4 Polarity with Multisystem Pathways in Neurodegeneration.

Characterization of the functional and clinical impacts of CACNA1A missense variants found in neurodevelopmental disorders.