A síndrome de Klüver-Bucy (SKC) é um distúrbio comportamental que ocorre quando ambos lobos temporais esquerdo e direito do cérebro não funcionam adequadamente ou são removidos.
Introdução
O que você precisa saber de cara
Lúpus eritematoso sistêmico pediátrico é uma doença autoimune rara que afeta múltiplos órgãos em crianças, manifestando-se com sintomas como ascite, erupções cutâneas, úlceras orais e insuficiência renal. Pode estar associado a positividade de anticorpos antifosfolipídicos e a alterações neurológicas.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Entender a doença
Do básico ao detalhe, leia no seu ritmo
Preparando trilha educativa...
Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 24 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 54 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
4 genes identificados com associação a esta condição. Padrão de herança: Not applicable.
Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P. Does not act on ceramide 1-phosphate, lysophosphatidic acid or phosphatidic acid (PubMed:16782891). Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway (PubMed:11756451, PubMed:12815058, PubMed:16782891). Regulates the intracellular levels of the bioactive sphingolipid metabolite S1P that regulates diverse biological processes
Endoplasmic reticulum membraneCell membrane
Transcriptional regulator mainly expressed in hematopoietic cells that plays a critical role in cellular growth, differentiation and immune response (PubMed:10961885, PubMed:37256972, PubMed:8943379). Plays a key role in the differentiation of T-helper 1 cells and the production of interferon-gamma (PubMed:12213961, PubMed:35614130). Also participates in multiple neutrophil functions including chemotaxis and production of the neutrophil extracellular traps (By similarity). After IL12 binding to
CytoplasmNucleus
Systemic lupus erythematosus 11
A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Sodium-independent sulfate anion transporter (PubMed:12713736, PubMed:27125215). Can transport other anions including bicarbonate, thiosulfate and oxalate by mediating sulfate-thiosulfate, sulfate-hydrogencarbonate and sulfate-oxalate anion exchange (PubMed:12713736, PubMed:27125215). Mediates oxalate-hydrogencarbonate anion exchange (By similarity)
Cell membraneBasolateral cell membrane
Nephrolithiasis, calcium oxalate, 1
A form of nephrolithiasis, a condition in which urinary supersaturation leads to stone formation in the urinary system. Patients manifest acute renal colic with severe pain originating in the flank. Patients with small, non-obstructing stones or those with staghorn calculi may be asymptomatic. The majority of renal calculi contain calcium. CAON1 is characterized by calcium oxalate kidney stones.
Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediate
CytoplasmNucleusLipid droplet
Variantes genéticas (ClinVar)
215 variantes patogênicas registradas no ClinVar.
Vias biológicas (Reactome)
28 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Lúpus eritematoso sistêmico de início na idade pediátrica
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Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
Pesquisa e ensaios clínicos
4 ensaios clínicos encontrados.
Publicações mais relevantes
Clinical, laboratory, and histopathological characteristics of pediatric lupus nephritis: a retrospective study in a national referral center in Mexico.
Pediatric lupus nephritis (LN) remains a major cause of morbidity and mortality, yet data from Latin American populations are limited. This study aimed to describe the clinical, laboratory, and histopathological characteristics of pediatric LN and identify prognostic factors associated with renal replacement therapy (RRT). We conducted a retrospective cross-sectional study including patients <18 years of age with LN diagnosed between 2020 and 2024 at a national referral center in Mexico. Demographic, clinical, immunological, histopathological, and therapeutic variables at diagnosis were analyzed. Multivariable logistic regression was performed to identify predictors of RRT. Eighty patients were included (83% female; mean age 15.1 ± 2.8 years). Median proteinuria was 41 mg/m²/h; hematuria and leukocyturia were present in 46% and 26% of patients, respectively. All patients were ANA positive, with frequent hypocomplementemia and elevated anti-double-stranded DNA titers. Among biopsied patients, class IV was the most common histological subtype (60%). Proliferative forms were associated with reduced glomerular filtration rate (<90 mL/min/1.73 m²; p = 0.012) and higher activity index scores (p = 0.04), while chronicity indices were low. Fifteen patients (18.8%) required RRT, and mortality was 6.25%. In multivariable analysis, hypoalbuminemia (<2.5 g/dL) was independently associated with RRT (OR 6.04; 95% CI 1.33-27.50; p = 0.020). This study represents one of the largest pediatric LN cohorts reported from Mexico. Proliferative forms were associated with greater inflammatory activity and impaired renal function at diagnosis. Hypoalbuminemia emerged as a simple and accessible biomarker for early risk stratification of severe renal outcomes.
Active Pediatric Systemic Lupus Erythematosus in Fars Province, Iran: Associations With Geographical and Meteorological Determinants-A Retrospective Cross‑Sectional Study.
Pediatric systemic lupus erythematosus (SLE) is a complex autoimmune disease influenced by genetic and environmental factors such as sunlight and temperature. This retrospective study investigated the association between meteorological and geographical factors and active pediatric SLE in Fars province, southwest Iran. The residential addresses of pediatric patients with active SLE who were hospitalized at the main referral hospital of southwest Iran in Shiraz City between March 2016 and January 2023 were extracted from their medical records and geographically mapped. The influence of meteorological factors, such as temperature, humidity, evaporation, rainfall, as well as geographical parameters including land cover, slope, and altitude, on active pediatric SLE was evaluated using geographic information system (GIS) analysis. Data were analyzed using univariate and multivariate binary logistic regression analysis. This study included 143 pediatric patients with active SLE from 34 out of a total of 8181 city/village areas. There was a significant positive association between urban setting and active pediatric SLE (OR = 75.949, CI = 9.521-605.846) while mean annual rainfall demonstrated a significant negative association (OR = 0.997, CI = 0.994-1.000) in the univariate analysis. Multivariate analysis revealed that urban setting was the only significant factor positively correlated with active pediatric SLE (OR = 56.567, CI = 6.731-745.372). There was no association between other meteorological and environmental factors and active pediatric SLE. This study found that living in urban areas and lower annual rainfall are significant risk factors for active pediatric SLE in Fars province, probably due to increased exposure to pollutants and ultraviolet radiation. While previous studies have linked SLE activity to temperature and humidity, no such associations were observed here, highlighting the need for further research on regional environmental influences on SLE.
CAR T cells in pediatric systemic lupus erythematosus.
Pediatric systemic lupus erythematosus (SLE) is associated with high disease severity and significantly higher morbidity and mortality compared to adult-onset SLE, making it a particularly challenging condition to manage. Chimeric antigen receptor (CAR) T-cell therapy holds significant promise for improving outcomes in refractory pediatric SLE. However, the use of CAR T-cell therapy in pediatric patients presents unique challenges, including difficulty in collecting sufficient T cells. Pediatric patients may experience distinct side effects, such as age-specific toxicities or more pronounced neurotoxic events, requiring tailored monitoring and management. Additionally, the psychological impact on children and their families, facing potentially life-threatening treatment protocols, must be carefully addressed. To date, only four children with SLE have been treated with CAR T cells, highlighting the early stage of research in this area. The clinical outcomes provide hope that CAR T-cell therapy could offer a breakthrough in treating pediatric SLE; however, main limitations remain the small number of patients and the relatively short follow-up. More data are needed to fully assess the safety, efficacy, and long-term outcomes in this vulnerable population. Key Points • Pediatric SLE is characterized by more severe manifestations, higher morbidity, and increased mortality compared to adult-onset SLE. • CAR T-cell therapy shows promise as a potential treatment for refractory pediatric SLE aiming ideally towards long-term, drug-free remission. • CAR T-cell therapy in pediatric SLE presents unique challenges, including age-related toxicities, technical difficulties, and ethical considerations. • To date, results are available from only a handful of children with SLE treated with CAR T cells. Expected advancements in CAR T-cell technology, along with data from ongoing clinical trials involving children with SLE, will determine the pace and extent of CAR T-cell therapy application in pediatric SLE.
Case Report: Rare aplastic anemia in pediatric systemic lupus erythematosus: a case series and systematic literature review.
Systemic lupus erythematosus (SLE) is a complex autoimmune disease in which the immune system mistakenly attacks healthy cells and tissues. This condition can impact various organs and systems, including the hematological system, where aplastic anemia (AA) emerges as a particularly severe and rare complication. Relevant clinical manifestations and treatment experiences must be shared and updated urgently. This manuscript presents the clinical features, examination, and treatment of two pediatric SLE patients with AA. And a systemic search of MEDLINE, EMBASE, LILACS, SciELO, and Scopus, using MeSH headings and keywords for "Aplastic Anaemia" and "Systemic Lupus Erythematosus". Both of our cases were severe, resulting in one death. Our systematic literature review identified 32 eligible studies. We found a total of 38 patients, and along with the two patients from our case series, there were 9 out of 40 SLE patients who experienced alopecia areata as children. In all 40 patients, 52% (21 out of 40) developed AA at the onset of SLE. The infection rate was concerning, with 16 out of 40 patients affected. While 83% (33 out of 40) of the patients showed improved outcomes, all seven patients who died had contracted an infection. SLE with AA is rare in both children and adults. Although the prognosis of this dangerous disease is optimistic in terms of data, it is still necessary to be vigilant, and early bone marrow examination, infection prevention, and on-time treatment are crucial.
Association of Mitochondrial DNA Haplogroups with Pediatric Systemic Lupus Erythematosus Disease Activity, Damage Scores, and Lupus Nephritis.
Mitochondria, which have critical roles in energy metabolism and oxidative regulation, also have a role in immune regulation including T cell activation, NET formation, inflammation, and apoptosis. More than 50% of those with systemic lupus erythematosus (SLE) have lupus nephritis due to kidney damage from immune complex deposition. Disease severity is reported to be greater in certain lineages. Mitochondrial DNA (mtDNA) haplogroups, which reflect maternal lineages, may modulate immune balance and disease outcomes in SLE. Methods: DNA was extracted from 25 consecutive, consenting pediatric patients that fulfilled the 1997 criteria for SLE and their maternal mitochondrial DNA (mtDNA) haplogroups were determined through next-generation sequencing (NGS). Results: This study evaluated the associations between mtDNA haplogroups, lupus nephritis, and organ damage in four mtDNA haplogroups: African (n = 5), Amerindian (n = 12), Asian (n = 4), and Caucasian (n = 4). Clinical data, SLE Disease Activity Index (SLEDAI-2K), SLICC Damage Index (SDI), and renal biopsy findings were analyzed. Median SLEDAI-2K scores were higher in Amerindian (10) and African (8) patients than in the Caucasian (5.5) and Asian (3) groups, with significant differences between Amerindian vs. Caucasian (p = 0.045) and Amerindian vs. Asian (p = 0.008). Irreversible organ damage (SDI > 1) was more frequent in Amerindian (54%) and African (40%) patients. Lupus nephritis occurred most often and most severely (Class III-IV, CKD) in the Amerindian (85%) and African (80%) groups, while Caucasian and Asian patients more often showed milder, membranous disease without CKD. Conclusion: Although limited by the small sample size, pediatric SLE severity and renal involvement were found to be greater in Amerindian and African mtDNA haplogroups, suggesting that mitochondrial lineage may contribute to ethnic disparities in SLE.
Publicações recentes
Damaged glomeruli in proliferative pediatric lupus nephritis exhibit a C5a-C5aR1 induced fibrotic transcriptional program.
Long-term outcomes of patients with moderate-severe pediatric systemic lupus erythematosus treated with combination rituximab and cyclophosphamide therapy: A single center cohort experience and review of literature.
From Nerve to Autoimmunity: Acute Guillain-Barré Syndrome in a 4-Year-Old with Early-Onset Pediatric Systemic Lupus Erythematosus.
Clinical, laboratory, and histopathological characteristics of pediatric lupus nephritis: a retrospective study in a national referral center in Mexico.
Active Pediatric Systemic Lupus Erythematosus in Fars Province, Iran: Associations With Geographical and Meteorological Determinants-A Retrospective Cross‑Sectional Study.
📚 EuropePMC209 artigos no totalmostrando 155
Clinical, laboratory, and histopathological characteristics of pediatric lupus nephritis: a retrospective study in a national referral center in Mexico.
Frontiers in pediatricsActive Pediatric Systemic Lupus Erythematosus in Fars Province, Iran: Associations With Geographical and Meteorological Determinants-A Retrospective Cross‑Sectional Study.
Health science reportsAssociation of Mitochondrial DNA Haplogroups with Pediatric Systemic Lupus Erythematosus Disease Activity, Damage Scores, and Lupus Nephritis.
Journal of clinical medicineClinical efficacy and short-term prognosis of belimumab in the treatment of systemic lupus erythematosus in children.
American journal of translational researchIncidence and risk factors of herpes zoster infection in pediatric systemic lupus erythematosus.
Pediatric rheumatology online journalBiomarkers in Pediatric Neuropsychiatric Systemic Lupus Erythematosus: A Systematic Review.
Life (Basel, Switzerland)Identification of circRNA expression signatures correlated with disease severity in pediatric systemic lupus erythematosus.
Frontiers in immunologyPrognostic factors for disease progression and mortality of childhood-onset lupus nephritis in the Philippines: a retrospective cohort study in a tertiary hospital.
Pediatric rheumatology online journalOphthalmic manifestations of systemic lupus erythematosus at a quaternary children's hospital.
Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and StrabismusA Rare Case of Cold Antibody-Mediated Autoimmune Haemolytic Anaemia in Early Systemic Lupus Erythematosus.
CureusProtein-losing enteropathy as initial presentation of pediatric systemic lupus erythematosus: A rare case report from Vietnam and literature review.
International journal of immunopathology and pharmacologyCase Report: Rare aplastic anemia in pediatric systemic lupus erythematosus: a case series and systematic literature review.
Frontiers in pediatricsCAR T cells in pediatric systemic lupus erythematosus.
Clinical rheumatologyPrevalence of metabolic syndrome in low-income childhood-onset systemic lupus erythematosus patients.
Advances in rheumatology (London, England)Closed circuit artificial ıntelligence model named morgaf for childhood onset systemic lupus erythematosus diagnosis.
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Narra JEarly Atherosclerosis in Pediatric Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis.
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LupusEffect of an Electronic Pill Bottle on Hydroxychloroquine Adherence in Pediatric Lupus: Results of a Novel Direct-to-Family Pilot Trial.
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Pediatric rheumatology online journalAssay for interferon gamma release as a novel marker in pediatric patients with systemic lupus erythematosus.
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Indian journal of sexually transmitted diseases and AIDSUNCovering new causes of monogenic systemic lupus erythematosus.
Immunology and cell biologyHematological manifestation of Pediatric Systemic Lupus Erythematosus (SLE) - A single centered cross-sectional study.
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World journal of pediatrics : WJPBarriers and facilitators to medical care retention for pediatric systemic lupus erythematosus in South Africa: a qualitative study.
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Indian journal of nephrologyRituximab alleviates pediatric systemic lupus erythematosus associated refractory immune thrombocytopenia: a case-based review.
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LupusSynthetic Nucleic Acid Antigens in Localized Scleroderma.
International journal of molecular sciencesIL-10 and IFN-γ as markers for early recognition of pediatric systemic lupus erythematosus complicated with macrophage activation syndrome.
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Child neuropsychology : a journal on normal and abnormal development in childhood and adolescenceAssociation of soluble ST2 with disease activity in pediatric systemic lupus erythematosus.
Clinica chimica acta; international journal of clinical chemistryAccuracy and adequacy of photoprotection in pediatric systemic lupus erythematosus patients, and the effect of education on photoprotection: a prospective study.
Pediatric rheumatology online journalThe correlation between trajectories of serum C3 variability and clinical course in Pediatric-onset systemic lupus erythematosus.
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Frontiers in medicineDoes kidney biopsy in pediatric lupus patients "complement" the management and outcomes of silent lupus nephritis? Lessons learned from a pediatric cohort.
Pediatric nephrology (Berlin, Germany)Childhood-onset systemic lupus erythematosus in the first year of life with joint involvement: A case report and mini-review.
Journal of family medicine and primary careImmunogenicity of Hepatitis B Vaccine in Pediatric Systemic Lupus Erythematosus Patients.
The Pediatric infectious disease journalSystemic lupus of pediatric onset in Afro-Caribbean children: a cohort study in the French West Indies and French Guiana.
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Journal of nephrologyA case report of pediatric systemic lupus erythematosus with diffuse alveolar hemorrhage following COVID-19 infection: Causation, association, or chance?
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Journal of clinical pharmacologyAssociation of Serum Vitamin D with Active Human Cytomegalovirus Infections in Chinese Children with Systemic Lupus Erythematosus.
Japanese journal of infectious diseasesBone remodeling serum markers in children with systemic lupus erythematosus.
Pediatric rheumatology online journalAnalysis of Peripheral Blood Basophils in Pediatric Systemic Lupus Erythematosus.
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Frontiers in pediatricsRecurrent macrophage activation syndrome as the initial manifestation of paediatric systemic lupus erythematosus.
LupusHemophagocytic Lymphohistiocytosis Gene Variants in Childhood-Onset Systemic Lupus Erythematosus With Macrophage Activation Syndrome.
The Journal of rheumatologyNovel Mutations in ACP5 and SAMHD1 in a Patient With Pediatric Systemic Lupus Erythematosus.
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LupusPediatric systemic lupus erythematosus: phagocytic defect and oxidase activity of neutrophils.
Pediatric researchCeliac Disease in Juvenile Idiopathic Arthritis and Other Pediatric Rheumatic Disorders.
Journal of clinical medicineIschemic Vaso-occlusive Retinopathy as Initial Presentation in Pediatric Systemic Lupus Erythematosus: A Case Report.
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ReumatologiaHematological involvement in pediatric systemic lupus erythematosus: A multi-center study.
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The Journal of rheumatologyRituximab use in pediatric systemic lupus erythematosus: Indications, efficacy and safety in an Indian cohort.
LupusMacrophage Activation Syndrome in Pediatric Systemic Lupus Erythematosus: A Systematic Review of the Diagnostic Aspects.
Frontiers in medicineJuvenile Systemic Lupus Erythematosus Presenting with Esophagitis and Severe Oral Mucositis.
Case reports in rheumatologyWithdrawal of "Hematological involvement in pediatric systemic lupus erythematosus: A multi-center study".
LupusIgG and IgA autoantibodies against L1 ORF1p expressed in granulocytes correlate with granulocyte consumption and disease activity in pediatric systemic lupus erythematosus.
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LupusWITHDRAWN: Hematological involvement in pediatric systemic lupus erythematosus: A multi-center study.
LupusIs podocytopathy another image of renal affection in p-SLE?
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LupusAtypical Presentation of Pediatric Systemic Lupus Erythematosus Complicated by Cryptococcal Meningitis.
Case reports in medicinePediatric systemic lupus erythematosus with lupus anticoagulant hypoprothrombinemia syndrome-A case series with review of literature.
LupusShrinking lung syndrome treated with rituximab in pediatric systemic lupus erythematosus: a case report and review of the literature.
Pediatric rheumatology online journalPredicting Macrophage Activation Syndrome in Childhood-onset Systemic Lupus Erythematosus Patients at Diagnosis.
The Journal of rheumatologyThe Performances of the ACR 1997, SLICC 2012, and EULAR/ACR 2019 Classification Criteria in Pediatric Systemic Lupus Erythematosus.
The Journal of rheumatologyUpdate on Outcome Measures for Pediatric Systemic Lupus Erythematosus.
Arthritis care & researchSIGLEC1 (CD169) is a sensitive biomarker for the deterioration of the clinical course in childhood systemic lupus erythematosus.
LupusAutoimmune thyroid diseases, autoimmune hepatitis, celiac disease and type 1 diabetes mellitus in pediatric systemic lupus erythematosus: Results from the CARRA Legacy Registry.
LupusBullous lupus as the first manifestation of systemic lupus erythematosus in the pediatric population: A diagnostic challenge in daily practice.
LupusPerformance and psychometric properties of lupus impact tracker in assessing patient-reported outcomes in pediatric lupus: Report from a pilot study.
LupusManagement of Pediatric Systemic Lupus Erythematosus: Focus on Belimumab.
Drug design, development and therapyNocturnal blood pressure dipping as a marker of endothelial function and subclinical atherosclerosis in pediatric-onset systemic lupus erythematosus.
Arthritis research & therapyThe status of FOXP3 gene methylation in pediatric systemic lupus erythematosus.
Allergologia et immunopathologiaGenetic heterogeneity of pediatric systemic lupus erythematosus with lymphoproliferation.
MedicineHydroxychloroquine in Patients with Rheumatic Disease Complicated by COVID-19: Clarifying Target Exposures and the Need for Clinical Trials.
The Journal of rheumatologyUrticarial vasculitis in pediatric systemic lupus erythematosus.
Pediatric dermatologyLupus Mesenteric Vasculitis: A Rare Initial Presentation of Pediatric Systemic Lupus Erythematosus.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseasesPatterns of Healthcare Use and Medication Adherence among Youth with Systemic Lupus Erythematosus during Transfer from Pediatric to Adult Care.
The Journal of rheumatologyPediatric systemic lupus erythematosus patients in South Africa have high prevalence and severity of cardiac and vascular manifestations.
Pediatric rheumatology online journalValidation of the 2019 European League Against Rheumatism/American College of Rheumatology Criteria Compared to the 1997 American College of Rheumatology Criteria and the 2012 Systemic Lupus International Collaborating Clinics Criteria in Pediatric Systemic Lupus Erythematosus.
Arthritis care & researchQuality of Care in Childhood-onset Systemic Lupus Erythematosus: Report of an Intervention to Improve Cardiovascular and Bone Health Screening.
The Journal of rheumatologyRituximab-associated Hypogammaglobulinemia in pediatric patients with autoimmune diseases.
Pediatric rheumatology online journalAcute pancreatitis and macrophage activation syndrome in pediatric systemic lupus erythematosus: case-based review.
Rheumatology internationalUnique Characteristics of Prepubertal Onset Systemic Lupus Erythematosus.
International journal of pediatricsPTPN22 Gene Polymorphisms in Pediatric Systemic Lupus Erythematosus.
Fetal and pediatric pathologyA mutation in PIK3CD gene causing pediatric systemic lupus erythematosus: A case report.
MedicineThe behavior of neutrophil extracellular traps and NADPH oxidative activity in pediatric systemic lupus erythematosus: relation to disease activity and lupus nephritis.
Clinical rheumatologyClinical manifestations, immunological features and prognosis of Chinese pediatric systemic lupus erythematosus: A single-center study.
International journal of rheumatic diseasesDiagnostic value of serum high-mobility group box-1 in pediatric systemic lupus erythematosus.
International journal of rheumatic diseasesThe role of 5-methoxytryptophan in pediatric-onset lupus nephritis: A retrospective cohort study.
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhiIncidence and risk factors of osteomyelitis in adult and pediatric systemic lupus erythematosus: a nationwide, population-based cohort study.
LupusChild-onset systemic lupus erythematosus is associated with a higher incidence of myopericardial manifestations compared to adult-onset disease.
LupusPediatric systemic lupus erythematosus. Retrospective analysis of clinico-laboratory parameters and their association with systemic lupus erythematosus disease activity index score.
Saudi medical journalInsights Gained From the Study of Pediatric Systemic Lupus Erythematosus.
Frontiers in immunologyPediatric Systemic Lupus Erythematosus: Learning From Longer Follow Up to Adulthood.
Frontiers in pediatricsExome sequencing revealed C1Q homozygous mutation in Pediatric Systemic Lupus Erythematosus.
Allergologia et immunopathologiaUse of echocardiography at diagnosis and detection of acute cardiac disease in youth with systemic lupus erythematosus.
LupusDNA induction of MDM2 promotes proliferation of human renal mesangial cells and alters peripheral B cells subsets in pediatric systemic lupus erythematosus.
Molecular immunologySerum IP-10 is useful for identifying renal and overall disease activity in pediatric systemic lupus erythematosus.
Pediatric nephrology (Berlin, Germany)Approach to Membranous Lupus Nephritis: A Survey of Pediatric Nephrologists and Pediatric Rheumatologists.
The Journal of rheumatologyMalignancy in Pediatric-onset Systemic Lupus Erythematosus.
The Journal of rheumatologyReduction of CD19 autoimmunity marker on B cells of paediatric SLE patients through repressing PU.1/TNF-α/BAFF axis pathway by miR-155.
Growth factors (Chur, Switzerland)Efficacy and Safety of Rituximab in the Management of Pediatric Systemic Lupus Erythematosus: A Systematic Review.
The Journal of pediatricsUnraveling the expression of microRNA-27a* & NKG2D in peripheral blood mononuclear cells and natural killer cells of pediatric systemic lupus erythematosus patients.
International journal of rheumatic diseasesCarotid intima-media thickness and arterial stiffness in pediatric systemic lupus erythematosus.
LupusMass cytometry identifies a distinct monocyte cytokine signature shared by clinically heterogeneous pediatric SLE patients.
Journal of autoimmunityLenalidomide for refractory cutaneous manifestations of pediatric systemic lupus erythematosus.
LupusAn Update on Treatment and Management of Pediatric Systemic Lupus Erythematosus.
Rheumatology and therapyClinical characteristics of children with membranous lupus nephritis: the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry.
LupusTargeted B cell therapies in the treatment of adult and pediatric systemic lupus erythematosus.
LupusSevere disease presentation and poor outcomes among pediatric systemic lupus erythematosus patients in South Africa.
LupusAlcohol, smoking and illicit drug use in pediatric systemic lupus erythematosus patients.
Revista brasileira de reumatologiaDisparities in Psychiatric Diagnosis and Treatment for Youth with Systemic Lupus Erythematosus: Analysis of a National US Medicaid Sample.
The Journal of rheumatologyAcute pancreatitis as a cause of mortality in pediatric systemic lupus erythematosus: Results of a multiple cause-of-death analysis in France.
Seminars in arthritis and rheumatismIdiopathic Thrombocytopenic Purpura Masquerading Pediatric Systemic Lupus Erythematosus.
Indian journal of dermatologyIncreased activation of toll-like receptors-7 and -8 of peripheral blood mononuclear cells and upregulated serum cytokines in patients with pediatric systemic lupus erythematosus.
International journal of clinical and experimental medicineInterleukin-17A rs2275913, Interleukin-17F rs763780 and rs2397084 gene polymorphisms as possible risk factors in Juvenile lupus and lupus related nephritis.
AutoimmunityTargeting E2F1 and c-Myc expression by microRNA-17-5p represses interferon-stimulated gene MxA in peripheral blood mononuclear cells of pediatric systemic lupus erythematosus patients.
Discovery medicinePractice patterns and approach to kidney biopsy in lupus: a collaboration of the Midwest Pediatric Nephrology Consortium and the Childhood Arthritis and Rheumatology Research Alliance.
Pediatric rheumatology online journalAutoantigen microarrays reveal autoantibodies associated with proliferative nephritis and active disease in pediatric systemic lupus erythematosus.
Arthritis research & therapyHigh titer anti-basement membrane antibodies in a subset of patients with pediatric systemic lupus erythematosus.
American journal of nephrologyAvascular necrosis in pediatric systemic lupus erythematosus: a brief report and review of the literature.
Pediatric rheumatology online journalPediatric systemic lupus erythematosus presenting with coronary arteritis: A case series and review of the literature.
Seminars in arthritis and rheumatismPediatric systemic lupus erythematosus in a single nephrology unit.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi ArabiaIncidence and prognosis of systemic lupus erythematosus in a 35 year period in Fukushima, Japan.
Pediatrics international : official journal of the Japan Pediatric SocietyCytomegalovirus in pediatric systemic lupus erythematosus: prevalence and clinical manifestations.
LupusAssociações
Organizações que acompanham esta doença — pra ter apoio e orientação
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Clinical, laboratory, and histopathological characteristics of pediatric lupus nephritis: a retrospective study in a national referral center in Mexico.
- Active Pediatric Systemic Lupus Erythematosus in Fars Province, Iran: Associations With Geographical and Meteorological Determinants-A Retrospective Cross‑Sectional Study.
- CAR T cells in pediatric systemic lupus erythematosus.
- Case Report: Rare aplastic anemia in pediatric systemic lupus erythematosus: a case series and systematic literature review.
- Association of Mitochondrial DNA Haplogroups with Pediatric Systemic Lupus Erythematosus Disease Activity, Damage Scores, and Lupus Nephritis.
- Damaged glomeruli in proliferative pediatric lupus nephritis exhibit a C5a-C5aR1 induced fibrotic transcriptional program.
- Long-term outcomes of patients with moderate-severe pediatric systemic lupus erythematosus treated with combination rituximab and cyclophosphamide therapy: A single center cohort experience and review of literature.
- From Nerve to Autoimmunity: Acute Guillain-Barré Syndrome in a 4-Year-Old with Early-Onset Pediatric Systemic Lupus Erythematosus.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:93552(Orphanet)
- MONDO:0019725(MONDO)
- Lupus Eritematoso Sistemico(PCDT · Ministério da Saúde)
- GARD:19219(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Q55788836(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
