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Pelagra
ORPHA:97352CID-10 · E52CID-11 · 5B5C.0DOENÇA RARA

A pelagra é um distúrbio nutricional causado por uma deficiência de niacina (vitamina B3) ou de seu precursor (triptofano), observada principalmente na Ásia e na África, onde geralmente é causada por má nutrição. É caracterizada por dermatite (eritema fotodistribuído simétrico que pode ser acompanhado por vesículas e bolhas, e que evolui para pele hiperceratótica e hiperpigmentada), sintomas gastrointestinais (diarreia) e distúrbios neuropsiquiátricos (demência). Pode ser fatal sem um manejo correto.

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Introdução

O que você precisa saber de cara

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A pelagra é um distúrbio nutricional causado por uma deficiência de niacina (vitamina B3) ou de seu precursor (triptofano), observada principalmente na Ásia e na África, onde geralmente é causada por má nutrição. É caracterizada por dermatite (eritema fotodistribuído simétrico que pode ser acompanhado por vesículas e bolhas, e que evolui para pele hiperceratótica e hiperpigmentada), sintomas gastrointestinais (diarreia) e distúrbios neuropsiquiátricos (demência). Pode ser fatal sem um manejo correto.

Publicações científicas
1.424 artigos
Último publicado: 2026 Mar 24
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SUS: Sem cobertura SUSScore: 0%
CID-10: E52
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Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🧬
Pele e cabelo
8 sintomas
🫃
Digestivo
5 sintomas
🧠
Neurológico
5 sintomas
👁️
Olhos
2 sintomas
💪
Músculos
1 sintomas
📏
Crescimento
1 sintomas

+ 21 sintomas em outras categorias

Características mais comuns

90%prev.
Deficiência de vitamina B3
Muito frequente (99-80%)
55%prev.
Bolhas anormais na pele
Frequente (79-30%)
55%prev.
Apetite pobre
Frequente (79-30%)
55%prev.
Desnutrição
Frequente (79-30%)
55%prev.
Glossite
Frequente (79-30%)
55%prev.
Dor
Frequente (79-30%)
43sintomas
Muito frequente (1)
Frequente (27)
Ocasional (15)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 43 características clínicas mais associadas, ordenadas por frequência.

Deficiência de vitamina B3Vitamin B3 deficiency
Muito frequente (99-80%)90%
Bolhas anormais na peleAbnormal blistering of the skin
Frequente (79-30%)55%
Apetite pobrePoor appetite
Frequente (79-30%)55%
DesnutriçãoMalnutrition
Frequente (79-30%)55%
GlossiteGlossitis
Frequente (79-30%)55%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico1.424PubMed
Últimos 10 anos200publicações
Pico202026 papers
Linha do tempo
2026Hoje · 2026🧪 2017Primeiro ensaio clínico📈 2020Ano de pico
Publicações por ano (últimos 10 anos)

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Genética e causas

O que está alterado no DNA e como passa nas famílias

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Nenhum gene associado encontrado

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Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

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Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Pelagra

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Ensaios clínicos abertos e novidades científicas recentes

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Publicações mais relevantes

🥇Melhor nível de evidência: Revisão sistemática
Timeline de publicações
204 papers (10 anos)
#1

Pellagra in Contemporary Clinical Practice (2000-2023): A Systematic Review.

International journal of dermatology2026 Mar 24

Pellagra's clinical presentation, etiological factors, and treatment in the early 21st century remain underexplored. This study aimed to update the understanding of pellagra's clinical and etiological aspects with a reappraisal of its treatment and prevention. We searched PubMed and Scopus up to January 9, 2023, to identify relevant studies. The reference lists of all included articles were also carefully screened to identify any additional studies. We included case reports, case series, and case-control studies documenting confirmed cases of pellagra between 2000 and 2023. The review protocol was registered with PROSPERO (CRD42022381416). The search identified 918 studies, of which 133 met the inclusion criteria, comprising 1212 pellagra cases. Cutaneous manifestations were the most common (98.63%), followed by gastrointestinal (59.4%) and neurological (54.2%) signs. Complete symptom resolution occurred on average within 27.42 days of vitamin B3 supplementation. Dietary deficiency remained the predominant cause of pellagra (85%), and it was particularly common in populations affected by food insecurity or humanitarian crises, accounting for 93% of cases. Alcohol misuse was reported in 9.6% of cases. Isoniazid was the leading drug-related cause (14.3%). Other contributing factors included gastrointestinal disorders and prior surgeries associated with malabsorption. These findings indicate an evolving etiological pattern in pellagra: dietary deficiency remains the primary driver, yet medication-induced and malabsorption-related cases are increasingly reported. Targeted niacin supplementation strategies for high-risk populations may improve outcomes and enable more efficient, lower-dose therapeutic approaches once underlying causes are addressed.

#2

Marchiafava-Bignami Disease and Pellagra in a Chronic Alcohol User: A Reversible Case of Cognitive Impairment.

Cureus2026 Jan

Marchiafava-Bignami disease (MBD) is a rare complication of chronic alcoholism characterized by demyelination of the corpus callosum. Pellagra, resulting from niacin (vitamin B3) deficiency, typically presents with dermatitis, diarrhea, and dementia. Both MBD and pellagra are often associated with severe nutritional deficiencies. We describe the case of a 56-year-old man with alcohol use disorder admitted after a syncopal episode, presenting with disorientation, apathy, and photosensitive desquamative lesions on sun-exposed skin. Brain MRI revealed T2 hyperintensity in the splenium and body of the corpus callosum, compatible with subacute MBS. Laboratory tests confirmed niacin deficiency, establishing concomitant pellagra. The patient received B-complex vitamin supplementation and was maintained in alcohol abstinence. His cognitive and dermatologic condition improved markedly, with near-complete recovery after six months. This case underlines the importance of recognizing nutritional deficiencies in alcohol-related neuropsychiatric presentations.

#3

Epidermal NAD+ deficiency induces IL-36-mediated skin inflammation and acanthosis.

JCI insight2026 Mar 23

Nicotinamide adenine dinucleotide (NAD+) is essential for cellular metabolism, DNA repair, and stress responses. NAD+ is synthesized from nicotinamide, nicotinic acid (collectively termed niacin), and tryptophan. In humans, deficiencies in these nutrients result in pellagra, marked by dermatitis, diarrhea, and dementia. The dermatitis associated with pellagra typically manifests as photodermatosis in sun-exposed areas. This study examined the effects of NAD+ deficiency on skin homeostasis using epidermis-specific Nampt-conditional KO (Nampt-cKO) mice. These mice displayed substantial NAD+ depletion, reduced poly(ADP-ribose) polymerase (PARP) activity, and increased DNA damage. Consequently, Nampt-cKO mice developed spontaneous skin inflammation and epidermal hyperplasia. RNA-seq and IHC analyses demonstrated increased IL-36 cytokine expression, suggesting that DNA repair-related genomic stress triggers keratinocyte-driven IL-36 production, which promotes inflammation. Furthermore, reduced COL17A1 expression and elevated thymic stromal lymphopoietin (TSLP) levels were observed. NAD+ repletion by transdermal supplementation of nicotinamide mononucleotide (NMN) suppressed the rise of IL-36 levels and skin inflammation. These findings underscore the importance of Nampt-mediated NAD+ metabolism for epidermal stability and indicate that NAD+ depletion may contribute to IL-36-mediated skin inflammation, offering insights for therapeutic strategies in inflammatory skin disorders.

#4

Pellagra-Fine arts and literature: A short journey from Pietro Belloti and Johann Wolfgang Goethe to John Wesley Caroll and Amedeo John Engel Terzi.

Clinics in dermatology2026 Feb 04

Pellagra is a non-hereditary disorder of the niacin and tryptophan metabolism. Cutaneous and gastrointestinal signs and symptoms are early signs of the disease, but neuropsychiatric findings follow, if the disease is not recognized and treated soon enough. Although pellagra had not been identified as a separate entity before 1735, artists noticed the characteristic cutaneous manifestations. An example is Pietro Bellotti's masterpiece Vecchia popolana con un ragazzo (Old Peasant Woman with a Boy; ca 1680-1690) with a most realistic style. In 1786, the German writer and scientist Goethe traveled to Northern Italy. In his book Italienische Reise (Italian Journey), he made remarks about cutaneous findings in the rural population suggesting pellagra. He missed the scaling and fissuring of skin, as he traveled in the autumn and not spring, when the disease has its seasonal peak. The association of pellagra with art is further illustrated by two examples of the early 20th century-painter John Wesley Carroll from Kansas and medical illustrator Amedeo John Engel Terzi from Sicily. Their multicolored illustrations supported education about the disease before high-quality color photography became available.

#5

[Pellagra secondary to chronic alcoholism in Costa Rica].

Nutricion hospitalaria2026 Jan 09

Introduction: pellagra is a disease caused by a deficiency of niacin (vitamin B3) or tryptophan, its precursor. Case report: we present the case of a 67-year-old Costa Rican male patient, alcoholic and homeless, with chronic ulcers on the lower limbs, photosensitive dermatitis, gait disturbance, mild cognitive impairment, and dysthymia. A diagnosis of pellagra was made based on clinical findings, which was later confirmed by a positive response to vitamin supplementation. Discussion: a review of pellagra, a condition that is increasingly underdiagnosed, was conducted; in this case, it presented with 2 of the 3 classic manifestations described in the literature. Introducción: la pelagra es una enfermedad carencial causada por déficit de niacina (vitamina B3) o de su precursor, el triptófano. Caso clínico: se presenta el caso de un paciente masculino costarricense de 67 años, alcohólico y habitante de la calle, con úlceras crónicas en los miembros inferiores, dermatitis fotosensible, trastorno de la marcha, deterioro cognitivo leve y distimia, en quien se diagnosticó la pelagra con base en los hallazgos clínicos, que posteriormente se confirmó ante la respuesta positiva a la suplementación vitamínica. Discusión: se realizó una revisión sobre la pelagra, una patología cada vez menos diagnosticada, que en esta ocasión se presentó con 2 de las 3 manifestaciones clásicas descritas en la literatura.

Publicações recentes

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📚 EuropePMC1.040 artigos no totalmostrando 184

2026

Pellagra in Contemporary Clinical Practice (2000-2023): A Systematic Review.

International journal of dermatology
2026

Recognizing pellagra in patients with chronic alcohol dependence.

Medicina clinica
2026

Marchiafava-Bignami Disease and Pellagra in a Chronic Alcohol User: A Reversible Case of Cognitive Impairment.

Cureus
2026

Epidermal NAD+ deficiency induces IL-36-mediated skin inflammation and acanthosis.

JCI insight
2026

Pellagra-Fine arts and literature: A short journey from Pietro Belloti and Johann Wolfgang Goethe to John Wesley Caroll and Amedeo John Engel Terzi.

Clinics in dermatology
2026

[Pellagra secondary to chronic alcoholism in Costa Rica].

Nutricion hospitalaria
2025

Steroid-Resistant Rash With Neuropsychiatric Deterioration and Weight Loss: A Modern-Day Case of Pellagra.

Cureus
2026

The Impact of Bariatric Surgery on the Development and Progression of Dermatologic Diseases: A Narrative Review.

Dermatology and therapy
2025

Pellagra in Complex Clinical Settings: A Case Involving Bariatric Surgery, Whipple Procedure, and Alcohol Use Disorder.

Cureus
2025

Pellagra and anorexia nervosa: a rare diagnosis that should not be overlooked.

European journal of dermatology : EJD
2025

Possible Coexistence of Pellagra in a Malnourished Patient with Seizure and Multiple Cerebrovascular Foci: A Case Report.

Reports (MDPI)
2025

Chronic Diarrhea and Alcoholism: Unravelling the Connection to Pellagra.

Cureus
2025

The Increasing Prevalence of Autism Spectrum Disorder in the U.S. and Its Implications for Pediatric Micronutrient Status: A Narrative Review of Case Reports and Series.

Nutrients
2025

Pellagra and Scurvy in a Patient With Relapsed Schizophrenia.

The Australasian journal of dermatology
2026

Phenobarbital-Induced Pellagra: A Diagnosis Not to Overlook.

Dermatitis : contact, atopic, occupational, drug
2025

Phenotypic diversity in NAXE mutations.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2025

Famished for Freedom: Pellagra and Medical Clemency at the Mississippi State Penitentiary.

Journal of the history of medicine and allied sciences
2024

Pellagra: An Unusual Cause for Altered Mental Status.

Cureus
2024

Pellagra in chronic alcoholism: An underdiagnosed condition in modern clinical practice.

The journal of the Royal College of Physicians of Edinburgh
2024

Relationship between alcohol consumption and cognitive impairment in the adult population over 60 years of age: A systematic review.

Revista Colombiana de psiquiatria
2024

Atypical presentation of pellagra with black urine: A clinical conundrum.

SAGE open medical case reports
2024

Case report: Pellagra presentation with dermatitis and dysphagia.

Frontiers in medicine
2024

Pellagra: Is It Here or is It Rare?

The Journal of the Association of Physicians of India
2024

Dementia associated with Pellagra: A rare case report.

Indian journal of psychiatry
2024

HIV-1 Infection Reduces NAD Capping of Host Cell snRNA and snoRNA.

ACS chemical biology
2024

Perianal rash: An uncommon presenting complaint of pellagra.

Journal of the European Academy of Dermatology and Venereology : JEADV
2024

Roux-en-Y Gastric Bypass and the Clinical Manifestations of Vitamin Deficiencies: Case Report and Literature Review.

Cureus
2023

Variable Presentations of Photodermatoses - A Case Series.

Indian journal of dermatology
2024

Pellagra linked to maize consumption in Gambo, Ethiopia: A call for awareness.

Journal of the European Academy of Dermatology and Venereology : JEADV
2024

The Conquest of Pellagra.

JAMA
2024

Alcoholic pellagrous encephalopathy: a case report on atypical presentation and diagnostic dilemma in alcohol-related disorders.

Annals of medicine and surgery (2012)
2023

Beyond the Bottle: Niacin Deficiency and Chronic Alcoholism.

Cureus
2023

SBA-15- and SBA-16-Functionalized Silicas as New Carriers of Niacinamide.

International journal of molecular sciences
2023

A Rare Case of Pellagra in a Chronic Alcoholic.

Cureus
2023

Pediatric patient presenting to the emergency department for rash.

Journal of the American College of Emergency Physicians open
2023

A child with persistent exfoliative dermatitis.

Pediatric dermatology
2023

A case of schizophrenia refuting mind-body dualism.

The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa
2023

Carcinoid syndrome-Symptoms and therapeutic approaches.

Hellenic journal of nuclear medicine
2023

NAD+, Axonal Maintenance, and Neurological Disease.

Antioxidants & redox signaling
2023

Pellagra, from history books to present clinical practice: a case report of pellagrous encephalopathy in the setting of alcohol withdrawal.

Internal medicine journal
2023

NAD+ Precursors and Intestinal Inflammation: Therapeutic Insights Involving Gut Microbiota.

Nutrients
2023

Protective effect of Bifidobacterium longum BB536 against nausea caused by pirfenidone in a mouse model of pellagra.

Bioscience of microbiota, food and health
2023

Pellagra Post-Roux-en-Y Gastric Bypass Surgery.

AACE clinical case reports
2023

[Pellagra-a clinical-dermatohistopathological diagnosis for skin picking disorder].

Dermatologie (Heidelberg, Germany)
2023

Pride, Prejudice, and Politics: The Pellagra Story-Part I.

Skinmed
2023

Pellagra and peripheral neuropathy secondary to tuberculosis treatment.

QJM : monthly journal of the Association of Physicians
2023

The Promise of Niacin in Neurology.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
2023

Pellagra: forgotten but not gone.

QJM : monthly journal of the Association of Physicians
2023

Mystical and mythological believes not only limited to psychiatric diseases? A dynamic overview of medicine.

Annals of medicine and surgery (2012)
2023

Beyond Pellagra-Research Models and Strategies Addressing the Enduring Clinical Relevance of NAD Deficiency in Aging and Disease.

Cells
2022

Scurvy: Rare Orthopaedic Complications Associated with Multinutritional Deficiencies.

European journal of case reports in internal medicine
2023

Pellagra in Zanzibar: a rare diagnosis.

International journal of dermatology
2022

Prevention and Control Strategies for Non-Communicable Disease: Goldberger, Pellagra and Rose Revisited.

Epidemiologia (Basel, Switzerland)
2022

Pellagra as a differential diagnosis in the confused patient on the acute medical unit.

BMJ case reports
2022

Analysis of real-world data and a mouse model indicates that pirfenidone causes pellagra.

ERJ open research
2022

Drug-Induced Photosensitivity: Clinical Types of Phototoxicity and Photoallergy and Pathogenetic Mechanisms.

Frontiers in allergy
2022

Systemic tryptophan homeostasis.

Frontiers in molecular biosciences
2022

Pellagra ohne Niacinmangel?

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
2022

Skin manifestations of neuroendocrine neoplasms: review of the literature.

Postepy dermatologii i alergologii
2022

Pellagra without niacin deficiency?

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
2022

NAXE deficiency: A neurometabolic disorder of NAD(P)HX repair amenable for metabolic correction.

Molecular genetics and metabolism
2022

Increased risk of pellagra in an alcoholic patient treated with antiepileptic drugs.

Annales de dermatologie et de venereologie
2022

Clinical analysis of alcoholic pellagra: A single-center retrospective study.

Journal of cosmetic dermatology
2022

COVID-19: Are We Facing Secondary Pellagra Which Cannot Simply Be Cured by Vitamin B3?

International journal of molecular sciences
2022

Analysis of the gut microbiome to validate a mouse model of pellagra.

Bioscience of microbiota, food and health
2022

Isoniazid-associated pellagra during mass scale-up of tuberculosis preventive therapy: a case-control study.

The Lancet. Global health
2022

Preventing pellagra during isoniazid preventive treatment.

The Lancet. Global health
2022

Pellagra With Casal Necklace Causing Secondary Schizophrenia With Capgras Syndrome in a Homeless Man.

The primary care companion for CNS disorders
2021

Cutaneous signs of nutritional disorders.

International journal of women's dermatology
2021

Dermatoscopic Patterns in Pellagra.

Skinmed
2021

Pathophysiology and clinical management of pellagra - a review.

Folia medica Cracoviensia
2021

Nutrition and art: 19th century images of scurvy, chlorosis, and pellagra.

Clinics in dermatology
2022

A case of alcoholic pellagra presenting with dementia and polyneuropathy.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2021

Azathioprine-induced pellagra in a child with autoimmune hepatitis: A case report and literature review.

Clinical case reports
2021

Biofortification of Cereals and Pulses Using New Breeding Techniques: Current and Future Perspectives.

Frontiers in nutrition
2021

The Fidgety Confused Man with Skin Rash.

Movement disorders clinical practice
2022

Casal's Necklace in Pellagra.

Journal of cutaneous medicine and surgery
2021

Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation.

Antioxidants (Basel, Switzerland)
2021

A peculiarly characterised case of isoniazid-induced pellagra- 2 Ds and a C: a case report.

The Pan African medical journal
2021

Determination of Vitamin B3 Vitamer (Nicotinamide) and Vitamin B6 Vitamers in Human Hair Using LC-MS/MS.

Molecules (Basel, Switzerland)
2022

The female mouse is resistant to mild vitamin B3 deficiency.

European journal of nutrition
2021

sQuiz your knowledge! A case of dermatitis, psychosis, and diarrhoea.

European journal of dermatology : EJD
2022

Effect of niacin supplementation on nausea-like behaviour in an isoniazid-induced mouse model of pellagra.

The British journal of nutrition
2021

Hidden Hunger: A Pellagra Case Report.

Cureus
2022

Pellagra dermatitis: five cases with dermoscopic findings.

International journal of dermatology
2021

[Pellagra-originally described in the Austrian Empire 250 years ago became a fatal endemic in some provinces].

Wiener klinische Wochenschrift
2021

Cyclone Idai as a Trigger for Pellagra Outbreak in Nhamatanda, Mozambique: A Case-Control Study.

The American journal of tropical medicine and hygiene
2021

Pellagra in South Africa from 1897 to 2019: a scoping review.

Public health nutrition
2021

Pruritic Rash and Diarrhea.

JAMA
2021

[Pellagra: an ancient disease in a modern world].

Nutricion hospitalaria
2021

Water-in-oil microemulsions composed of monoolein enhanced the transdermal delivery of nicotinamide.

International journal of cosmetic science
2021

Dermatological Manifestations in Inflammatory Bowel Diseases.

Journal of clinical medicine
2021

Pellagra a review exploring causes and mechanisms, including isoniazid-induced pellagra.

Photodermatology, photoimmunology & photomedicine
2021

[Carcinoid syndroma - diagnosis and management].

Vnitrni lekarstvi
2021

Hypersensitivity to Vitamins with a Focus on Immediate-Type Reactions: Food or Drug Allergy?

Endocrine, metabolic & immune disorders drug targets
2019

Global Concerns with B Vitamin Statuses: Biofortification, Fortification, Hidden Hunger, Interactions, and Toxicity.

Comprehensive reviews in food science and food safety
2020

Protocol for a Case-Control Study to Investigate the Association of Pellagra With Isoniazid Exposure During Tuberculosis Preventive Treatment Scale-Up in Malawi.

Frontiers in public health
2021

Pellagra: An old, new differential diagnosis in dementia patients?

Revista espanola de geriatria y gerontologia
2020

Two Multivariate Calibration Models for Assay of Niacin in Complex Mixtures with Its Official Impurities: A Pharmaceutical Application.

Journal of AOAC International
2020

ACE2 and gut amino acid transport.

Clinical science (London, England : 1979)
2020

The classic pellagra dermatitis.

BMJ case reports
2021

A Rare Skin Complication Associated With Crohn's Disease.

Gastroenterology
2020

Dr José Maria Vargas, standard bearer of Venezuelan medicine: The doctor and the statesman.

Clinics in dermatology
2020

sQUIZ your knowledge! A photosensitive rash in a patient with Crohn's disease.

European journal of dermatology : EJD
2020

Classical pellagra, the disease of 4 Ds, the forgotten entity.

The Pan African medical journal
2020

Pellagra Disease in a Hemodialysis Patient.

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia
2020

Toxicoproteomic Profiling of hPXR Transgenic Mice Treated with Rifampicin and Isoniazid.

Cells
2020

Chronic Diarrhea in a Drinker: A Breakthrough Case of Pellagra in the US South.

Journal of investigative medicine high impact case reports
2020

Visual Dermatology: Pellagroid Dermatitis.

Journal of cutaneous medicine and surgery
2020

Isoniazid-induced pellagra in a patient with Crohn's disease.

Clinical case reports
2020

Drug-related pellagra in a Ugandan woman on isoniazid preventative therapy.

IDCases
2020

The 4 D's of Pellagra and Progress.

International journal of tryptophan research : IJTR
2020

Pellagra secondary to selective eating in a child with autism.

Pediatric dermatology
2020

Necrolytic Acral Erythema: Current Insights.

Clinical, cosmetic and investigational dermatology
2020

Carcinoid Syndrome: A Review.

Cureus
2021

Pellagra in a Malawian woman.

Medicina clinica
2020

Chapter 6: Vitamins and Oral Health.

Monographs in oral science
2020

Pellagra: 4 D's and 8 Points.

Advances in clinical neuroscience & rehabilitation : ACNR
2020

Gastrointestinal: Life-threatening diarrhea due to pellagra in an elderly patient.

Journal of gastroenterology and hepatology
2019

Role of Nicotinamide in Genomic Stability and Skin Cancer Chemoprevention.

International journal of molecular sciences
2019

[Cutaneous manifestations of nutritional deficiencies].

Revue medicale suisse
2019

Pellagra, a re-emerging disease: a case report of a girl from a community ravaged by insurgency.

The Pan African medical journal
2020

Pellagrous dermatitis: a forgotten entity.

Postgraduate medical journal
2020

Pellagra, an Almost-Forgotten Differential Diagnosis of Chronic Diarrhea: More Prevalent Than We Think.

Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
2019

Public Health Aspects in the Prevention and Control of Vitamin Deficiencies.

Current developments in nutrition
2019

Pellagra in the USA: unusual manifestations of a rare entity.

BMJ case reports
2020

Pellagra and anorexia nervosa: a case report.

Eating and weight disorders : EWD
2019

Nicotinamide and NAFLD: Is There Nothing New Under the Sun?

Metabolites
2019

Cutaneous Metastasis of Internal Tumors.

Dermatologic clinics
2020

Metabolic diseases in Andean paleopathology: Retrospect and prospect.

International journal of paleopathology
2019

Elderly patient of Crohn's disease with dementia and edematous red plaques on dorsum of hands.

European journal of internal medicine
2019

Nicotinamide and Demographic and Disease transitions: Moderation is Best.

International journal of tryptophan research : IJTR
2019

Verrucous dermatophytosis on photoexposed areas resembling pellagra in acquired immunodeficiency syndrome.

Indian journal of dermatology, venereology and leprology
2019

Association of Schizophrenia Risk With Disordered Niacin Metabolism in an Indian Genome-wide Association Study.

JAMA psychiatry
2019

Pellagra in isoniazid preventive and antiretroviral therapy.

IDCases
2019

Pellagra and pellagra-like erythema in a hospital setting in Lomé, Togo : retrospective study from 1997 to 2017.

Medecine et sante tropicales
2019

The unwavering doctor who unraveled a medical mystery.

International journal of women's dermatology
2019

[Skin Manifestations of Pellagra].

Brain and nerve = Shinkei kenkyu no shinpo
2019

Pellagra and Alcohol Dependence Syndrome: Findings From a Tertiary Care Addiction Treatment Centre in India.

Alcohol and alcoholism (Oxford, Oxfordshire)
2019

Vitamin D: part II; cod liver oil, ultraviolet radiation, and eradication of rickets.

International orthopaedics
2018

Recognising the return of nutritional deficiencies: a modern pellagra puzzle.

BMJ case reports
2019

From the Editor Pellagra, Osler, Roberts, Goldberger, the Atherosclerotic Diet, Niacin, the Beginning of the Atherosclerotic Epidemic, and the First Lipid-Altering Drug.

The American journal of cardiology
2019

Autophagy in malnutrition-associated dermatoses.

The Journal of dermatology
2018

A case of isoniazid-induced pellagra aggravated by secondary anorexia presenting with an amino acid and vitamin-deficient profile.

European journal of dermatology : EJD
2018

Pellagra Secondary to GI Malignancy and Fluorouracil-Based Chemotherapy.

Journal of oncology practice
2018

Docetaxel induced pellagroid dematitis.

Indian journal of dermatology, venereology and leprology
2018

Vitamin B3 in Health and Disease: Toward the Second Century of Discovery.

Methods in molecular biology (Clifton, N.J.)
2017

Half and Half Nails in a Healthy Person.

Acta dermatovenerologica Croatica : ADC
2018

Azathioprine-induced pellagra in neuromyelitis optica: A case report and review of literature.

Multiple sclerosis and related disorders
2018

What disease did goethe witness during his journey through the Italian Alps? Was it pellagra or another disease of malnutrition?

Nutrition & dietetics : the journal of the Dietitians Association of Australia
2018

Malnutrition and skin disease in Far East prisoners-of-war in World War II.

Clinical and experimental dermatology
2017

Photosensitive disorders in HIV.

Southern African journal of HIV medicine
2018

Kenneth John Carpenter, Ph.D. (1923-2016).

The Journal of nutrition
2020

Prevalence of obesity and diabetes in the socioeconomic transition of rural Mayas of Yucatan from 1962 to 2000.

Ethnicity & health
2017

Pellagra affecting a patient with Crohn's disease.

Anais brasileiros de dermatologia
2017

Joseph Goldberger-Public Health Champion and Investigator of Pellagra.

JAMA dermatology
2017

Paleopathological rigor and differential diagnosis: Case studies involving terminology, description, and diagnostic frameworks for scurvy in skeletal remains.

International journal of paleopathology
2019

Photosensitivity in drug induced pellagra.

Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia
2017

Alcoholic Pellagra as a Cause of Altered Mental Status in the Emergency Department.

The Journal of emergency medicine
2017

Necrolytic Acral Erythema in Seronegative Hepatitis C.

Case reports in dermatology
2017

Meat Intake and the Dose of Vitamin B3 - Nicotinamide: Cause of the Causes of Disease Transitions, Health Divides, and Health Futures?

International journal of tryptophan research : IJTR
2017

[Severe neuropsychiatric symptoms due to vitamin b3 deficiency].

Presse medicale (Paris, France : 1983)
2017

Severe pellagra masked by concurrent plaque psoriasis: a case report of a hidden diagnosis.

Dermatology online journal
2017

'Shrouded in a dark fog': comparison of the diagnosis of pellagra in Venice and general paralysis of the insane in the United Kingdom, 1840-1900.

History of psychiatry
2017

Depletion of Epidermal Langerhans Cells in the Skin Lesions of Pellagra Patients.

The American Journal of dermatopathology
2017

An Outbreak of Pellagra in the Kasese Catchment Area, Dowa, Malawi.

The American journal of tropical medicine and hygiene
2017

Diets derived from maize monoculture cause maternal infanticides in the endangered European hamster due to a vitamin B3 deficiency.

Proceedings. Biological sciences
2016

Photodermatoses: Kids are not just little people.

Clinics in dermatology
2017

Drug-induced photosensitivity: new insights into pathomechanisms and clinical variation through basic and applied science.

The British journal of dermatology
2016

Pellagra Secondary to Medication and Alcoholism: A Case Report and Review of the Literature.

Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
2016

Hereditary lactate dehydrogenase M-subunit deficiency with late-developing pustular psoriasis-like lesions.

The Journal of dermatology
2016

Pellagra: a rare complication of isoniazid therapy.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
2016

Nicotinamide Riboside Is a Major NAD+ Precursor Vitamin in Cow Milk.

The Journal of nutrition
2016

[A non-infectious "erysipela"].

La Revue de medecine interne
2016

Skin diseases among elderly patients attending skin clinic at the Regional Dermatology Training Centre, Northern Tanzania: a cross-sectional study.

BMC research notes
2016

Scaly Erythematous Acral Eruption: Question. Scaly erythematous acral eruption.

The American Journal of dermatopathology
2015

A case of alcoholic pellagra encephalopathy presenting with spinal myoclonus.

Neurology. Clinical practice
2015

Wernicke encephalopathy and pellagra in an alcoholic and malnourished patient.

BMJ case reports
2015

Pellagra's Three Ds: Dermatology, Death, and Dracula.

JAMA dermatology
2016

Niacin (Vitamin B3) Supplementation in Patients with Serotonin-Producing Neuroendocrine Tumor.

Neuroendocrinology
2015

Goose skin in a girl with Ehlers-Danlos syndrome.

Journal of community hospital internal medicine perspectives
2015

Pellagra Pre-Goldberger: Rupert Blue, Fleming Sandwith, and The "Vitamine Hypothesis".

Transactions of the American Clinical and Climatological Association
2015

A Nampt inhibitor FK866 mimics vitamin B3 deficiency by causing senescence of human fibroblastic Hs68 cells via attenuation of NAD(+)-SIRT1 signaling.

Biogerontology
2015

Challenges for treatment of alcoholic neuropathic symptoms aggravated by niacin treatment of alcoholic pellagra.

General hospital psychiatry
Ver todos os 1.040 no EuropePMC

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Doenças relacionadas

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Pellagra in Contemporary Clinical Practice (2000-2023): A Systematic Review.
    International journal of dermatology· 2026· PMID 41876960mais citado
  2. Marchiafava-Bignami Disease and Pellagra in a Chronic Alcohol User: A Reversible Case of Cognitive Impairment.
    Cureus· 2026· PMID 41732620mais citado
  3. Epidermal NAD+ deficiency induces IL-36-mediated skin inflammation and acanthosis.
    JCI insight· 2026· PMID 41665963mais citado
  4. Pellagra-Fine arts and literature: A short journey from Pietro Belloti and Johann Wolfgang Goethe to John Wesley Caroll and Amedeo John Engel Terzi.
    Clinics in dermatology· 2026· PMID 41651388mais citado
  5. [Pellagra secondary to chronic alcoholism in Costa Rica].
    Nutricion hospitalaria· 2026· PMID 41313327mais citado
  6. Recognizing pellagra in patients with chronic alcohol dependence.
    Med Clin (Barc)· 2026· PMID 41832799recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:97352(Orphanet)
  2. MONDO:0019975(MONDO)
  3. GARD:10014(GARD (NIH))
  4. Busca completa no PubMed(PubMed)
  5. Artigo Wikipedia(Wikipedia)
  6. Q221441(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

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