Febre amarela

A Phase III Control Study of the Safety and Immunogenicity of vYF in Pediatric Population

NCT07103148

Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective

NCT07358910

VAC-SIP-YF (Vaccination- Safety & Immunogenicity During Pregnancy- Yellow Fever)

NCT06694766

Immunogenicity of Yellow Fever Vaccine 17D in Adults With Prior 17D Vaccination

Fase II

NCT05859490

A Trial to Evaluate the Safety and Immunogenicity of an Investigational Vaccine for the Prevention of Yellow Fever, and of an Investigational Vaccine for the Prevention of Rabies, in Healthy Adults

NCT06998004

NCT07103148 · A Phase III Control Study of the Safety and Immunogenicity o…Recrutando

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6 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

NCT07358910 · Risk Assessment of Community Spread of Multiple Endemic Infe…Recrutando

NCT06694766 · VAC-SIP-YF (Vaccination- Safety & Immunogenicity During Preg…Recrutando

NA

NCT05859490 · Immunogenicity of Yellow Fever Vaccine 17D in Adults With Pr…Recrutando

PHASE1, PHASE2

NCT06998004 · A Trial to Evaluate the Safety and Immunogenicity of an Inve…Recrutando

PHASE1

NCT01244802 · Characterization of Human Memory Immune Responses to Prior Y…Por convite

Outros ensaios clínicos

70 ensaios clínicos encontrados, 13 ativos.

Distribuição por fase

NCT04942210 · Study on an Investigational Yellow Fever Vaccine Compared Wi…Ativo

PHASE2

NCT05011123 · Study on an Investigational Yellow Fever Vaccine Compared Wi…Ativo

PHASE2

NCT04083430 · Cytotoxicity of Yellow Fever Specific CD8 T Cells Following …Ativo

NCT05644145 · Immunogenicity of Yellow Fever Vaccine in a Pediatric Popula…Ativo

NA

NCT02555072 · Immunity Period After One Dose of Yellow Fever Vaccine in Ad…Ativo

NCT06815835 · Non-interference Study of MR and Yellow Fever Vaccines Among…Em breve

NCT05450770 · Immunity to Yellow Fever in HIV-infected Patients 10 Years A…Em breve

NA

NCT05374317 · Study of the Safety and Immunogenicity of Reduced Doses of t…Concluído

NCT02743455 · A Trial to Evaluate the Safety, Reactogenicity, and Immunoge…Concluído

PHASE1

NCT07222059 · Phase 3 Single Arm, Open Study on vYF in AdultsConcluído

NCT07002060 · Phase 3 Randomized, Modified Double-blind, Active-controlled…Concluído

NCT04269265 · The Effect of Inflammation and Damage to Lymph Node Structur…Concluído

PHASE1, PHASE2

NCT00694655 · Human Immune Responses to Yellow Fever VaccinationConcluído

NCT04142086 · Dose-ranging Study of an Investigational Yellow Fever Candid…Concluído

PHASE1

Ver todos no ClinicalTrials.gov

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Timeline de publicações

3.835 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 3.835

#1

LRP8 is a functional receptor for yellow fever virus.

Nature microbiology2026 Mar 19

Yellow fever virus (YFV) is an arbovirus causing substantial human morbidity and mortality. The live-attenuated 17D strain serves as vaccine and is one of the most successful vaccines so far. Receptor usage between attenuated and pathogenic YFV strains remains unclear. Here we performed a barcoded, genome-wide human open-reading frame library screen and identified LRP8 (also named APOER2) as a receptor for YFV. We show that LRP8 expression increases YFV infection (17D and two clinical strains, BJ01 and Asibi) in cell lines by promoting entry. Adeno-associated virus-mediated expression of human LRP8 in mouse liver aggravates infection and pathology of the clinical strain BJ01. LRP8 knockdown decreases YFV infection in brain cells, primary human hepatocytes and mosquitoes. LRP8 directly interacts with YFV 17D particles via the viral envelope protein. A soluble LRP8 decoy protein can block YFV 17D and BJ01 infection. Our findings provide insights for understanding YFV entry, tropism and pathogenesis.

#2

Evolution and spillover dynamics of yellow fever at the forest-urban interface in Brazil.

Nature microbiology2026 Mar 11

Yellow fever virus (YFV) continues to threaten human and wildlife populations in the Americas, yet its transmission at the forest-urban interface remains unclear. Here we integrate ground- and canopy-level mosquito surveillance, systematic monitoring of non-human primate carcasses and viral metagenomics to describe the dynamics of a sylvatic YFV outbreak in a 186-hectare Atlantic Forest fragment embedded within metropolitan São Paulo, Brazil, between 2017 and 2018. Our analyses reveal that transmission was primarily driven by a single genetic cluster introduced during a period of high abundance of the main vector, Haemagogus leucocelaenus mosquitoes. A near-complete hepatitis A virus genome was detected in a YFV-infected howler monkey, suggesting potential co-infections at the human-wildlife interface. Phylogenetic and epidemiological modelling estimated a basic reproduction number, R0, for sylvatic yellow fever of 8.2 (95% CI 5.1-12.2), substantially higher than previous estimates for urban outbreaks. Our findings demonstrate that multisource surveillance could provide actionable early warnings in regions at risk for zoonotic spillover.

#3

Dose-dependent immune modulation in arboviral coinfections among febrile patients.

Frontiers in cellular and infection microbiology2026

Arboviruses pose substantial diagnostic and public health challenges in tropical regions where multiple pathogens co-circulate. Nigeria, with diverse ecological zones and limited surveillance infrastructure, represents a critical nexus for arboviral transmission, yet comprehensive data on seroprevalence, coinfection dynamics, immune modulation, and viral genetic diversity remain scarce. We conducted cross-sectional surveillance across three Nigerian ecological zones from January 2019 to December 2023. Sera from 871 participants were tested for IgG and IgM antibodies to dengue virus (DENV), chikungunya virus (CHIKV), Zika virus (ZIKV), yellow fever virus (YFV), West Nile virus (WNV), and Rift Valley fever virus (RVFV) using immunoblot assays. A stratified subset (n=300) underwent cytokine profiling for interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), and interleukin-10 (IL-10). IgM-positive samples underwent RT-PCR confirmation with genotype assignment through sequence comparison against GenBank reference strains. Overall IgM seropositivity indicating recent infection was 86.8% (756/871), with DENV most prevalent (59.6%; 95% CI: 56.3-62.8%), followed by CHIKV (49.4%), YFV (48.3%), ZIKV (19.7%), WNV (3.4%), and RVFV (2.3%). Coinfection with two or more arboviruses was detected in 61.2% (533/871) of participants. Seropositivity was highest in the tropical rainforest zone (94.2%) compared with Guinea savanna (84.5%) and Sudan savanna (80.4%; χ²=31.8, p<0.001). Cytokine profiling revealed significantly elevated concentrations of IL-6, TNF-α, IFN-γ, and IL-10 in dual and triple infections compared with mono-infections (all p<0.001), demonstrating dose-dependent immune modulation. All four DENV serotypes were identified, with DENV-2 predominating (59.9%). Molecular characterisation confirmed circulation of CHIKV East/Central/South African genotype (82.1%), DENV-2 Cosmopolitan genotype, and both African (71.2%) and Asian (28.8%) ZIKV lineages, with study sequences showing >99% nucleotide identity to established reference strains. These findings reveal extraordinarily high levels of arboviral infection and coinfection across Nigerian ecological zones. The dose-dependent cytokine elevation in coinfections suggests distinct immunopathological mechanisms. These data underscore the urgent need for multiplex diagnostics, genotype-specific monitoring, and climate-informed vector control strategies.

#4

Yellow fever in Latin America and the escalating risks in a changing eco-epidemiological landscape: a review.

Lancet regional health. Americas2026 Apr

Yellow fever (YF) remains a major public health concern in Latin America. We characterise the early-2025 outbreak, compare it with prior waves-especially Southeast Brazil (2016-2018)-and examine environmental, structural, and policy-related drivers. We reviewed regional surveillance data and mortality records from January to April 2025, comparing them to historical outbreak data. Case fatality rate (CFR), geographic spread, and population vulnerability patterns were analyzed. We also reviewed published literature and health alerts to contextualize contributing factors. In 2025, 301 confirmed cases and 124 deaths were reported (CFR 41.1%), mostly in Bolivia, Brazil, Colombia, and Peru, concentrated among unvaccinated populations at the forest-urban interface. Transmission remains sylvatic, but peri-urban spillover risk is rising. Deforestation, climate variability, cross-border migration, and political instability heighten vulnerability; surveillance is fragmented and vaccine uptake insufficient in high-risk groups. YF is re-emerging through intertwined biological, ecological, and socio-political forces. Preventing another large-scale epidemic requires strengthened, integrated surveillance, including Non-Human Primates (NHP) epizootics, equity-centred immunisation in remote areas, and coordinated regional action focused on prevention, early detection, and health-system resilience. La fiebre amarilla (FA) continúa siendo un importante problema de salud pública en América Latina. Caracterizamos el brote de inicios de 2025, lo comparamos con olas previas—en especial el del sudeste de Brasil (2016–2018)—y examinamos determinantes ambientales, estructurales y de política sanitaria. Revisamos datos regionales de vigilancia y registros de mortalidad de enero a abril de 2025, comparándolos con series históricas, particularmente el brote del sudeste de Brasil (2016–2018). Se analizaron las tasas de letalidad por casos (CFR), la expansión geográfica y los patrones de vulnerabilidad poblacional. También revisamos literatura publicada y alertas sanitarias para contextualizar los factores contribuyentes. En 2025 se notificaron 301 casos confirmados y 124 defunciones (CFR 41.1%), sobre todo en Bolivia, Brasil, Colombia y Perú, concentradas en poblaciones no vacunadas en la interfaz selva–urbana. La transmisión sigue siendo selvática, pero aumenta el riesgo de desbordamiento periurbano. La deforestación, la variabilidad climática, la migración transfronteriza y la inestabilidad política incrementan la vulnerabilidad; la vigilancia es fragmentada y la cobertura vacunal insuficiente en grupos de alto riesgo. La FA está reemergiendo por fuerzas biológicas, ecológicas y sociopolíticas entrelazadas. Prevenir otra epidemia de gran escala exige vigilancia fortalecida e integrada (incluidas epizootias en primates no humanos), inmunización centrada en la equidad en áreas remotas y acción regional coordinada enfocada en la prevención, la detección temprana y la resiliencia de los sistemas de salud. A febre amarela (FA) continua sendo uma grande preocupação de saúde pública na América Latina. Caracterizamos o surto inicial de 2025, comparamos com ondas anteriores—especialmente no sudeste do Brasil (2016–2018)—e examinamos os fatores ambientais, estruturais e relacionados a políticas. Revisamos dados regionais de vigilância e registros de mortalidade de janeiro a abril de 2025, comparando-os com dados históricos de surtos. Foram analisadas as taxas de letalidade por casos (CFR), a disseminação geográfica e os padrões de vulnerabilidade populacional. Também revisamos literatura publicada e alertas de saúde para contextualizar os fatores contribuintes. Em 2025, foram reportados 301 casos confirmados e 124 mortes (CFR 41.1%), principalmente na Bolívia, Brasil, Colômbia e Peru, concentrados em populações não vacinadas na interface floresta-urbana. A transmissão permanece silvestre, mas o risco de transbordamento periurbano está aumentando. A desflorestação, a variabilidade climática, a migração transfronteiriça e a instabilidade política aumentam a vulnerabilidade; a vigilância é fragmentada e a adesão à vacina insuficiente em grupos de alto risco. A FA está reemergindo por forças biológicas, ecológicas e sociopolíticas interligadas. Prevenir outra epidemia em grande escala requer vigilância fortalecida e integrada, incluindo epizootias em primatas não humanos (PNH), imunização centrada na equidade em áreas remotas e ação regional coordenada focada na prevenção, detecção precoce e resiliência dos sistemas de saúde.

#5

Spatial and social determinants of the 1857 yellow fever epidemic in Lisbon.

PLoS neglected tropical diseases2026 Mar

Despite the availability of a highly effective vaccine, yellow fever virus (YFV) is still endemic in 47 countries globally. Although disease due to YFV was first recorded in 1635, factors contributing to its spread remain poorly understood today. Using archival data from the nineteenth century, we digitalised and mapped the 1857 yellow fever (YF) epidemic in Lisbon, Portugal, to understand how transmission dynamics and spatial and environmental characteristics led to disparities in health outcomes between sociodemographic groups. We modelled the basic and effective reproduction number (R0 and Rt) and found that transmission dynamics throughout this pre-vaccination era epidemic are consistent with prevailing estimates (R0 ≃ 5). Transmission peaked at the end of October 1857 when YF was declared an epidemic, then declined until January 1858. YFV killed 4.2% of the population with infection attack rates ranging between 10.3-13.5%. Out of the 34 parishes in urban Lisbon, our hotspot analysis identified 15 statistically significant high-risk parishes near the coastline. Our maps, combined with a digital terrain model, show that the highest number of deaths occurred within connected streets confined in low-elevation built-up areas with homes. We discuss the potential role of wind and temperature in aiding mosquito dispersal across Lisbon, which were believed as the main historical environmental drivers of YF. More people died at home than in hospitals, and although working-aged men accounted for most fatalities, the highest probability of death was found among women working at home. Our study highlights the role of human-environment interactions in shaping a historical YF epidemic in a pre-vaccination urban setting and enhances our understanding of modern-day transmission dynamics.

Publicações recentes

Yellow fever virus infection in non-human primates: a systematic review and meta-analysis of prevalence, seroprevalence, and epizootic case reports (1950-2025).

📖 Revisão

Front Vet Sci2026

A targeted amplicon sequencing panel for cost-effective high-throughput genotyping of Aedes aegypti.

Parasit Vectors2026 Apr 15

Investigating antibody cross-reactivity and transmission dynamics of alphaviruses and flaviviruses using a multiplex serological assay.

Nat Commun2026 Apr 15

Preparedness for the emerging risk of yellow fever in the Americas.

Rev Panam Salud Publica2026

Ver todas no PubMed

📚 EuropePMC4.672 artigos no totalmostrando 198

Unique aspects of the acute kidney injury associated with infections in the tropics: presentation, challenges and opportunities.

Kidney international

Metagenomic surveillance of zoonotic yellow fever and spillover dynamics at a forest-urban interface.

LRP8 is a functional receptor for yellow fever virus.

Reemergence of yellow fever in Venezuela, 2025/2026.

One health (Amsterdam, Netherlands)

When yellow fever silenced the forest: Ecological collapse and reduced malaria transmission in the Rio de Janeiro Atlantic Forest, Brazil.

The Australasian journal of dermatology

Safety of Live and Live-Attenuated Vaccines in Patients Receiving Biologics and Small-Molecule Therapies for Dermatologic Diseases: A Systematic Review.

Transactions of the Royal Society of Tropical Medicine and Hygiene

A cohort study of the duration of immunity to yellow fever after 4 years of primary vaccination in children and adults.

Molecular biology and evolution

Soft selective sweeps predominate in the yellow fever mosquito Aedes aegypti.

Evolution and spillover dynamics of yellow fever at the forest-urban interface in Brazil.

Memorias do Instituto Oswaldo Cruz

Entomo-virological investigation during the epizootic outbreak of sylvatic yellow fever in Rio Grande do Sul, Brazil, between 2021 and 2022.

Journal of public health in Africa

Prioritisation and risk ranking of epidemic-prone diseases for emergency preparedness and response in Eastern Africa using a multi-criteria decision analysis framework, 2023.

Journal of public health in Africa

Nigeria's post-COVID-19 vaccine manufacturing ambitions: Opportunities and regional implications.

Frontiers in cellular and infection microbiology

Dose-dependent immune modulation in arboviral coinfections among febrile patients.

Lancet regional health. Americas

Yellow fever in Latin America and the escalating risks in a changing eco-epidemiological landscape: a review.

Pharmacoepidemiology and drug safety

Trends and Patterns of Adverse Drug Reaction Reporting in Sierra Leone: A Retrospective Analysis of VigiFlow Data (2008-2022).

The Journal of infectious diseases

Time for a New Yellow Fever Vaccine.

Spatial and social determinants of the 1857 yellow fever epidemic in Lisbon.

Lancet regional health. Americas

Yellow fever beyond the Amazon: surveillance challenges and the role of Callithrix spp. in sylvatic cycles in Brazil.

Clashing in Murky Waters: On Amphibian Mosquito Suppression.

Ecology and evolution

Mitochondrial COI gene based population genetic structure and diversity of Aedes aegypti populations across diverse climatic regions of India.

Acta tropica

Travel medicine and infectious disease

Yellow fever in older populations: Marked age- and sex-based disparities in case-fatality rates in Colombia, Brazil, and Peru.

Entomological surveillance of malaria vector: species, behaviors, and insecticide resistance in southern and central Benin.

Computational Insights into the Structural Dynamics of the E Protein's DIII Domain in Brazilian Yellow Fever Virus: Implications of Amino Acid Variations on Protein Plasticity and Potential Impact on Vaccine Efficacy.

ACS omega

Substitutions M478K and A482G in the polymerase of yellow fever virus confer resistance to sofosbuvir and uprifosbuvir in vitro.

Antiviral research

Archives of insect biochemistry and physiology

Histone Deacetylases Are Required for Aedes aegypti Female Reproduction and Embryonic Development.

International journal of biological macromolecules

Aedes aegypti Hsp70 has enhanced ATPase and protein protection under oxidative stress.

Journal of medical entomology

Artificial light at night as a potential driver of Aedes aegypti establishment in arid cities: insights from Las Vegas.

1'- and 4'-Cyano Modified Adenosine Analogs Against Prototypic Flavivirus RNA-Dependent RNA Polymerases.

Next-Generation HIV-1 Therapeutics in Co-Endemic Settings.

Biomedicines

Journal of virological methods

Cytokine-based rapid process control of live virus production: MCP-1 as a cross-family biomarker in Vero cells.

Metabolic quiescence of naive-like memory T cells precedes and maintains antigen-specific T cell memory.

Nature immunology

Klinicka mikrobiologie a infekcni lekarstvi

[A brief history and significance of the Czechoslovak army's Antiviral Serum Bank].

Preliminary estimation of the basic reproductive number of yellow fever in Colombia, 2024-2026.

Archives of insect biochemistry and physiology

Integrated In Silico, In Vivo, and Deep Learning Approaches in the Discovery of Novel Candidate Molecules for Aedes aegypti Control.

Metagenomic surveillance of undiagnosed febrile illness in Nigeria does not reveal the etiological agent for most patients.

Diurnal fluctuating temperature and larval resource level interact to influence the life history and behaviour of disease-transmitting mosquitoes.

Humoral and cellular responses to a tetravalent dengue vaccine (TAK-003) in adults from a dengue non-endemic region: An open-label phase 2 trial.

Genomic characterization of Sabiá virus in Brazil, 2019-2020: Implications for diagnostics, virus evolution, and receptor binding.

Current research in parasitology & vector-borne diseases

Entomological investigation of the 2023 chikungunya outbreak in Pouytenga, Burkina Faso, highlights the virus circulation in Aedes aegypti.

(Sero)prevalence of (re)emerging major arbovirus infections in Africa: a systematic review and meta-analysis protocol.

Systematic reviews

Tolerance to persistent cell-fusing agent virus infection in Aedes aegypti mosquitoes correlates with maintenance of lipid reserves.

BMC biology

Pulmonary Complications in Fatal Yellow Fever, Brazil, 2017-2019.

Revista do Instituto de Medicina Tropical de Sao Paulo

Yellow fever virus resurgence in Sao Paulo State, Brazil, 2024-2025.

Frontiers in veterinary science

An integrated surveillance in Zhejiang Province: ecological and pathogen survey of vectors and reservoir hosts in 2024.

Molecular Mechanisms of Antibody-Dependent Enhancement of Viral Infection.

Biochemistry. Biokhimiia

Global trends of pandemic-prone and epidemic-prone disease outbreaks in 2024.

BMJ global health

Current opinion in virology

Human genetics of susceptibility to live-attenuated viral vaccines.

Rwanda journal of medicine and health sciences

Rural Inhabitants' Perception-Induced Immunisation Status: The Case of Yellow Fever Vaccination in the Ashanti Region of Ghana.

Bacterial community structure and diversity of common mosquito species in Chengdu: Insights from PacBio third-generation sequencing and public health implications.

A Replication-Competent Flavivirus Genome with a Stable GFP Insertion at the NS1-NS2A Junction.

Biology

Revista da Sociedade Brasileira de Medicina Tropical

Sabethes mosquitoes (Diptera: Culicidae) associated with bamboo internodes in Pariquera-Açu and Cananeia, São Paulo State, Brazil.

The Journal of infectious diseases

New insights into an old vaccine: potency and breadth of neutralizing antibodies elicited by the yellow fever vaccine 17D are boosted by heterologous Orthoflavivirus infection.

The American journal of tropical medicine and hygiene

Endemicity of a Yellow Fever Virus Strain Revealed by Entomological Surveillance in Southeastern Senegal.

The American journal of tropical medicine and hygiene

Potent Monoclonal Antibodies Against Circulating Yellow Fever Virus Strains from Donors Immunized with the 17D Vaccine.

Proceedings of the National Academy of Sciences of the United States of America

Antagonism of RNA silencing in the yellow fever mosquito, Aedes aegypti, by the nsP2 protein of the prototype alphavirus.

Harnessing insect-derived oils for enhanced efficacy of plant-based repellents against disease-transmitting mosquitoes.

Technical validation and implementation of a multiplex real-time PCR for differential diagnostic detection of Zika virus, yellow fever virus, dengue virus and chikungunya virus (ZYDC-PCR).

Pyrethroids and organophosphate resistance in Aedes aegypti (Diptera: Culicidae) and their underlying mechanisms.

Journal of medical entomology

Molecular detection of insecticide resistance markers in Aedes aegypti (Diptera: Culicidae) populations from Haiti.

Frontiers in public health

Review of selected mosquito-borne diseases: arboviruses (dengue, chikungunya, Zika, West Nile, Japanese encephalitis, yellow fever) and parasitic diseases (malaria, lymphatic Filariasis).

Global epidemiology and evolutionary dynamics of arboviruses: A systematic review of surveillance, control strategies, and emerging threats.

Dialogues in health

The journal of climate change and health

The spread of infectious diseases in migration routes between caravans and resident communities: Modelling yellow fever in Central America.

medRxiv : the preprint server for health sciences

Yellow fever re-emergence in Tolima, Colombia 2024-25: an eco-epidemiological study.

Development and validation of a sample-to-result real time multiplex RT-PCR test for human African trypanosomiasis and arboviral febrile illnesses in the Democratic Republic of the Congo.

The L1014F Kdr mutation is associated with a higher prevalence and load of the Plasmodium-blocking symbiont Microsporidia MB In Anopheles Gambiae s.l. In Benin.

BMC microbiology

Revista da Sociedade Brasileira de Medicina Tropical

Surveillance Service of Yellow Fever in Non-Human Primates in the Federal District, Brazil, 2008-2022.

Revista da Sociedade Brasileira de Medicina Tropical

Distribution of yellow fever vectors in a disease-free area of Northeast Brazil.

The impact of maternal flavivirus infections on fetal neurological outcomes: a scoping review.

Virology journal

Review of mosquitoes in Ireland and of relevant mosquito-borne pathogens.

Irish veterinary journal

Memorias do Instituto Oswaldo Cruz

Entomo-virological investigation in urban forest fragments and intradomiciles during a dengue outbreak in Salinas, MG, Brazil.

Current issues in molecular biology

Strengthening Arboviral Epidemic Response Through Entomological Surveillance: Insights from Bobo-Dioulasso, Burkina Faso.

Journal of human immunity

Auto-Abs against type I IFNs: Strong, common, and global determinants of severe arboviral diseases.

Structural genomics sheds light on protein functions and remote homologs across the insect tree of life.

Cell research

Thermal stress responses on developmental time, survival, and wing morphometrics in desert and coastal strains of Aedes aegypti (Diptera: Culicidae) from India.

Acta tropica

Current opinion in virology

Human autoantibodies against type I interferons in severe viral disease.

The Yellow Fever Vaccine Journey: Milestones and Future Directions.

Vaccines

Pathogens (Basel, Switzerland)

Temporal and Geographical Patterns of Pacific Arboviral Vectors on Ebeye, Republic of the Marshall Islands: Insights from a Longitudinal Entomological Study.

International journal of molecular sciences

Opportunities and Challenges of mRNA and VLP Technologies for Pan-Flavivirus Vaccine Development: Focus on Conserved Quaternary Epitope Conformations.

International journal of molecular sciences

Application of Orthoflavivirus Pseudovirus Technology in Antiviral Research.

NUP98 regulates orthoflavivirus replication through interaction with vRNA and can be targeted for antiviral purposes.

Nucleic acids research

Occupational Infection Prevention Among Nurses and Laboratory Technicians Amidst Multiple Health Emergencies in Outbreak-Prone Country, D.R. Congo.

Cryopreservation of Anopheles gambiae Larvae.

Advanced biology

Travel medicine and infectious disease

Impact of the COVID-19 pandemic on travel medicine services in Taiwan, 2019-2022.

Proceedings of the National Academy of Sciences of the United States of America

Type I IFN autoantibodies underlie chikungunya live-attenuated vaccine encephalitis.

Diagnostic microbiology and infectious disease

From pandemic influenza to novel coronaviruses: emerging infectious diseases of the 21st century.

BMC global and public health

Estimating the impact of decreasing vaccination response times for outbreaks of vaccine-preventable diseases in low- and middle-income countries.

Advances in experimental medicine and biology

Lipid Metabolism in Insect Vectors of Diseases.

Low-dose yellow fever vaccination in infants: a randomised, double-blind, non-inferiority trial.

Lancet (London, England)

Yellow fever vaccine minimum fractional dosing does not extend to infants.

Lancet (London, England)

Preparation and application of YFV-17D-derived Anterograde Trans-neuronal Viral Vectors for Neuroscience Research.

Spillover risk for yellow fever virus is amplified by forest-urban interface in the Amazon.

Biology letters

Systematic review of Aedes aegypti control trials suggests publication bias related to author disclosure of conflicts of interest.

Bulletin of mathematical biology

RDA-PSO: A Computational Method to Quantify the Diffusive Dispersal of Insects.

Entomological surveillance in active dengue transmission areas of Santo Domingo de los Tsáchilas - Ecuador: Epidemiological importance of Aedes aegypti and the recent establishment of Aedes albopictus.

Acta tropica

Metagenomic Exploration of the Bacteriome Reveals Natural Wolbachia Infections in Yellow Fever Mosquito Aedes aegypti and Asian Tiger Mosquito Aedes albopictus.

Current microbiology

International journal of molecular sciences

Involvement of Multiple Ion Channels and Receptors in Mediating the Insecticidal and Repellent Actions of Limonene.

Molecular diagnosis of arboviruses (dengue, Chikungunya, yellow fever, Rift Valley fever, Mayaro, West Nile, and Zika viruses) in non-malaria acute febrile illnesses in Kenya's Garissa County, July 2023, and Mombasa County, July 2024.

Adverse events following immunization (AEFI) with fractional one-fifth and one-half doses of yellow fever vaccine compared to standard dose in children 9-23 months old in Uganda, 2019-2022 - final report.

Arboviruses circulation in Guinea: Overview and perspectives for public health.

GigaByte (Hong Kong, China)

Insecticide resistance dynamics in Aedes mosquitoes in Ghana.

GigaByte (Hong Kong, China)

Spatial and temporal distribution of Culex and Aedes mosquitoes in Ghana.

A case of disseminated intravascular coagulation by leptospirosis during the ongoing yellow fever outbreak in Colombia.

Methods in molecular biology (Clifton, N.J.)

Platforms to Evaluate Flavivirus-Induced Immunoinflammatory Responses and Their Pathogenesis.

Flavivirus NS1-triggered endothelial dysfunction promotes virus dissemination.

PLoS pathogens

Viral hepatitis as a differential diagnosis of yellow fever suspected cases in Cameroon: Prevalence and molecular characterization.

IJID regions

Development and Application of a Rapid Field Detection Technology for DENV-2 Based on the HUDSON Nucleic Acid Extraction-Free/RT-RAA/CRISPR-Cas12a System.

Monitoring Dengue Virus in Aedes aegypti to Improve Dengue Surveillance and Control in Puerto Rico.

Utility of TaqMan Array Cards for detection of acute febrile illness etiologies in patients suspected of viral hemorrhagic fever infections.

Insecticide-treated screening of windows for household protection against insecticide-resistant Anopheles gambiae sensu lato in Côte d'Ivoire: a semi-field trial.

Rapid virus-free production of recombinant yellow fever virus envelope protein and its in-depth biophysical analysis.

Pesticide biochemistry and physiology

Challenges in insecticide resistance management: Implications of alternating selection in the yellow fever mosquito, Aedes aegypti.

Journal of medical Internet research

Systematic Determinants of Global COVID-19 Burden: Longitudinal Time-Series Analysis Using Big Data-Driven Artificial Intelligence.

Exposure to 5G-NR electromagnetic fields affects larval development of Aedes aegypti mosquito.

Vertical transmission of mosquito microbiota and its effects on offspring development.

Plaque reduction neutralization test (PRNT50) for the detection of anti-yellow fever antibodies from clinical samples.

Serologic Evidence of Circulation of Six Arboviruses (Dengue Virus, Chikungunya Virus, Zika Virus, Rift Valley Virus, Yellow Fever Virus, Crimean-Congo Hemorrhagic Fever Virus) in Four Regions of Burkina Faso, West Africa.

Intensive Therapeutic Plasma Exchange for Severe Yellow Fever: What Is the Evidence? Comment on Ho et al. Intensive Therapeutic Plasma Exchange-New Approach to Treat and Rescue Patients with Severe Form of Yellow Fever. Trop. Med. Infect. Dis. 2025, 10, 39.

Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina)

[Presence of Aedes aegypti in a high altitude area in Bolivia].

Medical and veterinary entomology

Transposable elements in the transcriptome of Aedes (Stegomyia) aegypti (Linnaeus, 1762).

Journal of virological methods

Targeting Yellow-Fever Virus: Development of a specific aptamer to NS1 protein.

PLOS global public health

Timeliness of yellow fever specimen collection and transport in Ghana, 2018-2022.

Revista da Sociedade Brasileira de Medicina Tropical

Development of a simple trap using widely available materials for collecting immature Sabethines (Diptera: Culicidae) and first records of Sabethes batesi and Wyeomyia nigritubus in Sergipe, Brazil.

The Journal of infectious diseases

In vivo risk assessment of yellow fever virus transmission through breastfeeding, and mechanistic insights.

Evaluating the role of observational uncertainty in climate impact assessments: Temperature-driven yellow fever risk in South America.

PLOS climate

A triple-blinded randomized control trial to evaluate the safety and immunogenicity of fractional doses of COVID-19 vaccines (ChAd0x1, AD26.COV2. S, and BNT162B2) among Nigeria adults: the SIFCoVAN trial.

Trials

Revista colombiana de obstetricia y ginecologia

Expert consensus on vaccination as a primary prevention strategy for women of reproductive age, pregnant, or adulthood.

Reemergence of yellow fever virus in forest and periurban settings in Brazil.

Communications medicine

Emerging microbes & infections

Differences in Genetic Diversity between Early Isolates of Yellow Fever Virus Genotypes.

Immunological and transcriptomic profile of chimeric live-attenuated Zika vaccine linked to protection in non-human primates.

Nature communications

Reemergence of Yellow Fever, Magdalena Valley, Colombia, 2024-2025.

Analytical science advances

Chemometric Methods Applied to Infrared and Raman Spectroscopy for Arboviruses Diagnosis: A Systematic Review With Meta-Analysis.

Yellow Fever Virus in Aedes albopictus Mosquitoes from Urban Green Area, São Paulo State, Brazil.

Human vaccines & immunotherapeutics

Strategic positioning of immunization at the heart of Africa's health and development agenda.

Human vaccines & immunotherapeutics

Pharmacovigilance assessment of adverse events following yellow fever vaccination: Disproportionality analysis of VAERS reports, 2015-2025.

Frontiers in public health

Respiratory symptom burden, vaccination coverage, and preventive health practices among Sudanese Hajj pilgrims who traveled by sea.

Pickpocket315 affects male mating behavior in the yellow fever mosquito Aedes aegypti.

G3 (Bethesda, Md.)

Potential distribution of Aedes vittatus as an invasive species in North America.

PloS one

Sec61 translocon inhibitor flavitransin blocks selectively dengue virus polyprotein insertion in the ER with pan-orthoflavivirus antiviral potency.

Cell reports

Transactions of the Royal Society of Tropical Medicine and Hygiene

Spatiotemporal dynamics and determinants of yellow fever outbreaks in 21st century Brazil: an ecological study.

Yellow fever mortality in Brazil: an age-period-cohort study.

Revista de saude publica

Jugan geon-gang gwa jilbyeong

[Mosquito Surveillance at Airports and Seaports to Prevent and Control Emerging Mosquito-borne Diseases in the Republic of Korea, 2024].

Jugan geon-gang gwa jilbyeong

[Mosquito Surveillance at Airports and Seaports to Prevent and Control Emerging Mosquito-borne Diseases in Korea, 2023].

Jugan geon-gang gwa jilbyeong

[Identification of Culex quinquefasciatus Highlights the Need for Strengthened Vector Mosquito Surveillance in the Republic of Korea].

Beyond dengue and Oropouche: The urgent need for yellow fever preparedness in Cuba.

Pesticide biochemistry and physiology

Larvicidal efficacy of Varronia curassavica leaf phytochemicals against Aedes aegypti: anatomical, histological and cytotoxic analyses.

Biomedica : revista del Instituto Nacional de Salud

Outbreaks and incidence of vector-borne diseases in Colombia (2007-2024): Impact of climate change and deforestation.

The American journal of the medical sciences

Update on emerging and re-emerging vector-borne diseases.

Pathogens (Basel, Switzerland)

Standardized Diagnostic Assays for Omsk Hemorrhagic Fever Virus.

The Use of Disabled Insecticidal Proteins (DIPs) to Investigate the Interaction Between Aedes aegypti-Active Toxins from Bacillus thuringiensis.

Insects

Highly Sensitive Si-Based Electrolyte-Gated Transistor Array for Multiplexed Detection of Arboviruses.

Micromachines

Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil

Yellow fever vaccination coverage and knowledge, attitudes and practices: a cross-sectional study during an epizootic event in São Sebastião, Federal District, 2020.

Travel After Transplant: Demographics, Travel Trends, and Vaccination Practices of US Immunocompromised Travelers.

Transplantation

Development and application of a PCR-RFLP assay revealing widespread distribution of the pyrethroid resistance-associated VGSC V1016G mutation in Aedes albopictus from Guangyuan City, Sichuan Province of China.

Seroepidemiological Investigation of Arboviruses in Callithrix jacchus in Sergipe, Brazil.

EcoHealth

Journal of visualized experiments : JoVE

A Multiplex Serological Assay for the Detection of Antibody Responses to Arboviruses.

Journal of travel medicine

Dengue in deployed military personnel, 1905-2024: a systematic review of incidence, diagnostics and prevention.

Mimicry in the Bite: Shared Sequences Between Aedes aegypti Salivary Proteins and Human Proteins.

Proteomes

Discovery of a potent anti-Zika virus benzamide series targeting the viral protein NS4B.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Rationalizing and mitigating the risk of live-attenuated dengue vaccines.

Medical science monitor : international medical journal of experimental and clinical research

A Review of the Changing Global Impact of Arthropod-Borne Virus Diseases and Recent Initiatives from the World Health Organization.

A targeted amplicon sequencing panel for cost-effective high-throughput genotyping of Aedes aegypti.

The genomic diversity of arthropod-specific viruses reinforces the continental distribution pattern of Aedes aegypti.

Detection of Aedes (Fredwardsius) vittatus Mosquitoes, Yucatán Peninsula, Mexico, 2025.

Detection and genetic diversity of Wolbachia and its associated prophage WO in mosquito populations from Ethiopia.

Spatial-temporal analysis of natural hazards and disasters in the Greater Horn of Africa between 2010 and 2024 to inform disaster risk reduction, and surveillance and control strategies for climate and environmentally sensitive diseases.

BMJ open

Anti-NMDA receptor encephalitis following Murray Valley encephalitis: a case report.

ASM case reports

The Lancet. Global health

Safety and non-inferiority of multidose and single-dose vial formulations of EuTCV Vi-CRM197 versus Typbar TCV in healthy participants in Kenya and Senegal: a multicentre, observer-blind, randomised, phase 3 study.

Computational approaches for designing viral protease inhibitors.

The Enzymes

Neonatal tropical infections: A case series and clinical insights.

Tropical doctor

Proceedings of the National Academy of Sciences of the United States of America

Membrane-localized MET engages PVR to mediate extranuclear juvenile hormone signaling in Aedes aegypti.

Molecules (Basel, Switzerland)

Potential Antiviral Compounds from Hippeastrum puniceum Bulb Against Yellow Fever Virus: Bioassay-Guided Fractionation and In Silico Pharmacokinetic Analysis.

Nature reviews. Microbiology

Unlocking entry for yellow fever virus.

Clinical features of yellow fever in cases from Bolivia, Ecuador, Colombia, and Peru (2023-2025): A descriptive retrospective study.

Early detection of intracranial hemorrhage in Yellow Fever utilizing multimodal neuromonitoring: A case report.

Science progress

Contrasted impacts of commercial diets and rearing water on Aedes aegypti fitness and microbiota.

mSphere

2024

The first mitochondrial genome of Haemagogus equinus from Jamaica.

F1000Research

Coming of age: mRNA vaccines for orthoflaviviruses.

Trends in immunology

Author Correction: A single residue in the yellow fever virus envelope protein modulates virion architecture and antigenicity.

Nature communications

Virologie (Montrouge, France)

[Epidemiological situation of hepatitis E in Africa].

Annals of medicine and surgery (2012)

Exploring the national burden and challenges in the fight against yellow fever in the Democratic Republic of Congo: a review.

Annals of medicine and surgery (2012)

MRNA innovation: preparing for arboviruses and the next global outbreak.

Reproductive Aging Impacts the Seminal Fluid Proteome in the Yellow Fever Mosquito, Aedes aegypti.

Proteomics

Prioritization of future new vaccines introduction: The experience of the Ethiopian National Immunization Technical Advisory Group.

Nationwide surveillance detects yellow fever and chikungunya viruses in multiple Aedes mosquito species in Nigeria.

Taxonomic expansion and reorganization of Flaviviridae.

Assessment of vector control strategies based on mass Aedes (Stegomyia) mosquito trapping (AGOs traps) pilot study in a US-Mexico border region of South Texas.

Open forum infectious diseases

Field Evaluation of Mobile Molecular Differential Tests in DRC and Nigeria.

Multiple LDLR family members act as entry receptors for yellow fever virus.

Nature

Virologie (Montrouge, France)

Epidemiological situation of hepatitis E in Africa.

In Vivo Characterization and Tissue Tropism of a Wild-Type Yellow Fever Virus Isolate from the 2017-2018 Brazilian Outbreak in C57BL/6 IFNAR1-/- Mice.

AGS-v PLUS, a Mosquito Salivary Peptide Vaccine, Modulates the Response to Aedes Mosquito Bites in Humans.

Vaccines

Orthoflavivirus Vaccine Platforms: Current Strategies and Challenges.

Vaccines

Inferring Geographic Spread of Flaviviruses Through Analysis of Hypervariable Genomic Regions.

A new in vitro pre-clinical method for testing SARS-CoV-2 nasopharyngeal swabs.

The First National Record of the Invasive Mosquito Aedes vittatus (Diptera: Culicidae) in Mexico, a Threat to Public Health in Continental America.

Neotropical entomology

Journal of medical entomology

Comparative toxicity of the isoxazolines afoxolaner, fluralaner, and fluxametamide, and the meta-diamide broflanilide against adult Aedes aegypti (Diptera: Culicidae) and Anopheles quadrimaculatus (Diptera: Culicidae).

Primates; journal of primatology

Population densities of black-and-gold howler monkeys (Alouatta caraya) in northeastern Argentina and the possible influence of a yellow fever outbreak.