Um tumor benigno (que não se espalha para outras partes do corpo) que se origina nas células da parte da frente da glândula hipófise. O tumor pode produzir hormônios ou não. O diagnóstico pode ser feito com base em exames de imagem e/ou exames de sangue para medir os hormônios. Por estar localizado numa região do crânio chamada sela turca (onde a hipófise fica), o crescimento do tumor pode pressionar o quiasma óptico (onde os nervos da visão se cruzam) ou atingir o lobo temporal, o terceiro ventrículo e a parte de trás da base do crânio. Um sintoma físico frequentemente associado é a hemianopsia bitemporal (perda da visão periférica nos dois olhos), que pode progredir para uma perda de visão ainda maior.
Introdução
O que você precisa saber de cara
Um tumor benigno (que não se espalha para outras partes do corpo) que se origina nas células da parte da frente da glândula hipófise. O tumor pode produzir hormônios ou não. O diagnóstico pode ser feito com base em exames de imagem e/ou exames de sangue para medir os hormônios. Por estar localizado numa região do crânio chamada sela turca (onde a hipófise fica), o crescimento do tumor pode pressionar o quiasma óptico (onde os nervos da visão se cruzam) ou atingir o lobo temporal, o terceiro ventrículo e a parte de trás da base do crânio. Um sintoma físico frequentemente associado é a hemianopsia bitemporal (perda da visão periférica nos dois olhos), que pode progredir para uma perda de visão ainda maior.
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 94 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 231 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
11 genes identificados com associação a esta condição.
Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates t
CytoplasmNucleusEndosome membraneCell membrane
Pituitary adenoma 4, ACTH-secreting
A form of pituitary adenoma, a neoplasm of the pituitary gland and one of the most common neuroendocrine tumors. Pituitary adenomas are clinically classified as functional and non-functional tumors, and manifest with a variety of features, including local invasion of surrounding structures and excessive hormone secretion. Functional pituitary adenomas are further classified by the type of hormone they secrete. PITA4 results in excessive production of adrenocorticotropic hormone. This leads to hypersecretion of cortisol by the adrenal glands and ACTH-dependent Cushing syndrome. Clinical manifestations of Cushing syndrome include facial and truncal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes.
Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179)
NucleusCytoplasmCell membrane
Deubiquitinase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of polyubiquitin precursors as well as that of ubiquitinated proteins (PubMed:16214042, PubMed:34059922). Plays a role in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites. Plays an important role in cell cycle progression by deubiquitinating Aurora B/AURKB an
CytoplasmNucleusCell projection, cilium
Deafness, autosomal dominant, 85
A form of non-syndromic, sensorineural hearing loss. Sensorineural hearing loss results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA85 is characterized by progressive hearing loss, with onset in childhood or young adulthood.
Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:35618207, PubMed:36634798, PubMed:38653238, PubMed:9840937). Acts as a tumor suppressor in many tumor types; induces growth arrest or apop
CytoplasmNucleusNucleus, PML bodyEndoplasmic reticulumMitochondrion matrixCytoplasm, cytoskeleton, microtubule organizing center, centrosome
Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates
Nucleus
Familial multiple endocrine neoplasia type I
Autosomal dominant disorder characterized by tumors of the parathyroid glands, gastro-intestinal endocrine tissue, the anterior pituitary and other tissues. Cutaneous lesions and nervous-tissue tumors can exist. Prognosis in MEN1 patients is related to hormonal hypersecretion by tumors, such as hypergastrinemia causing severe peptic ulcer disease (Zollinger-Ellison syndrome, ZES), primary hyperparathyroidism, and acute forms of hyperinsulinemia.
May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation
Mitochondrion matrixNucleus
May inhibit the adenylyl cyclase-stimulating activity of guanine nucleotide-binding protein G(s) subunit alpha which is produced from the same locus in a different open reading frame
Cell membraneCell projection, ruffle
Receptor for glucocorticoids (GC) (PubMed:27120390, PubMed:37478846). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (PubMed:28139699). Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of ta
CytoplasmNucleusMitochondrionCytoplasm, cytoskeleton, spindleCytoplasm, cytoskeleton, microtubule organizing center, centrosomeChromosomeNucleus, nucleoplasm
Glucocorticoid resistance, generalized
An autosomal dominant disease characterized by increased plasma cortisol concentration and high urinary free cortisol, resistance to adrenal suppression by dexamethasone, and the absence of Cushing syndrome typical signs. Clinical features include hypoglycemia, hypertension, metabolic alkalosis, chronic fatigue and profound anxiety.
Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling
NucleusChromosome, telomereNucleus, PML body
Alpha-thalassemia/impaired intellectual development syndrome, X-linked
A disorder characterized by severe psychomotor retardation, facial dysmorphism, urogenital abnormalities, and alpha-thalassemia. An essential phenotypic trait are hemoglobin H erythrocyte inclusions.
Orphan receptor
Cell membrane
Pituitary adenoma 2, growth hormone-secreting
A form of pituitary adenoma, a neoplasm of the pituitary gland and one of the most common neuroendocrine tumors. Pituitary adenomas are clinically classified as functional and non-functional tumors, and manifest with a variety of features, including local invasion of surrounding structures and excessive hormone secretion. Functional pituitary adenomas are further classified by the type of hormone they secrete. PITA2 is a growth hormone-secreting benign neoplasm, also known as somatotropinoma. It clinically results in acromegaly, a condition characterized by coarse facial features, protruding jaw, and enlarged extremities. Excessive production of growth hormone in children or adolescents before the closure of epiphyses causes gigantism, a condition characterized by abnormally tall stature.
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for norma
Cell membrane
Usher syndrome 1D
USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa with sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH1 is characterized by profound congenital sensorineural deafness, absent vestibular function and prepubertal onset of progressive retinitis pigmentosa leading to blindness.
Variantes genéticas (ClinVar)
4,104 variantes patogênicas registradas no ClinVar.
Classificação de variantes (ClinVar)
Distribuição de 536 variantes classificadas pelo ClinVar.
Vias biológicas (Reactome)
79 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Adenoma hipofisário
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Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
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Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 5.345
Long-term trajectories of cognitive function, fatigue, and quality of life in patients after pituitary adenoma surgery: A retrospective study.
Pituitary adenomas (PAs) are common intracranial tumors where surgery is the primary treatment. While effective, many patients face persistent cognitive deficits, chronic fatigue, and diminished health-related quality of life (HRQoL) long after resection. Current literature lacks dynamic, long-term perspectives on how these heterogeneous outcomes evolve and interact over time. This single-center retrospective cohort study (N = 295) tracked patients between June 2021 and December 2024 who underwent first-time PA resection. Longitudinal assessments from 6 months to 5 years postoperatively included the Montreal Cognitive Assessment (MoCA), Fatigue Severity Scale (FSS), and SF-36 survey. Latent class growth analysis (LCGA) was employed to identify distinct recovery trajectories. Multinomial logistic regression identified baseline predictors, and chi-square tests analyzed inter-trajectory associations. LCGA identified heterogeneous patterns: three classes for cognition (Stable-High, 54.9%; Moderate-Improving, 33.2%; Persistent-Deficient, 11.9%), three for fatigue, and distinct pathways for HRQoL. Key predictors for poor recovery trajectories included older age, lower education, Cushing's disease, and the need for postoperative hormone replacement. Notably, severe chronic fatigue was a potent predictor of poor mental HRQoL (aOR = 8.15, 95% CI: 3.50-18.99). A robust "symptom cluster" was identified, where cognitive impairment and severe fatigue consistently co-occurred with poor life satisfaction. Recovery after pituitary surgery follows diverse, interrelated long-term trajectories rather than a uniform path. Identifying this specific postoperative symptom cluster underscores the necessity of integrated, holistic management. Our findings facilitate early risk stratification and provide a foundation for developing personalized rehabilitation strategies targeting vulnerable patient populations.
AI at the Sella Turcica: Multi-Model Large Language Model Evaluation in Pituitary Adenomas.
Large language models (LLMs) are explored as clinical decision-support tools in complex medical fields. However, their reliability and clinical usefulness in multidisciplinary management of pituitary adenomas remain insufficiently evaluated using validated, clinician-based frameworks. Do LLMs differ in informational quality, clinical reasoning, and expert satisfaction when applied to pituitary adenoma-related clinical scenarios? A prospective comparative study evaluated three LLMs: ChatGPT-5.0, Claude Opus 4.1, and Gemini 2.5 Flash. A standardized prompt set covering general knowledge, surgical decision-making, endocrine evaluation, patient education, and MRI-based scenarios was submitted to each model identically. Outputs were anonymized and independently assessed by 10 board-certified doctors using three validated instruments: the Quality Assessment of Medical Artificial Intelligence (QAMAI), the Artificial Intelligence Performance Instrument (AIPI), and the Artificial Intelligence Satisfaction and Performance Evaluation Questionnaire (AISPE-Q). Claude Opus 4.1 achieved the highest performance across all major domains. Aggregate QAMAI scores were highest for Claude Opus 4.1 (4.39 ± 0.66), compared with ChatGPT-5.0 (4.12 ± 0.74) and Gemini 2.5 Flash (4.07 ± 0.76; p = 0.018). Clinical reasoning assessed by AIPI was superior for Claude Opus 4.1 versus Gemini 2.5 Flash and ChatGPT-5.0. Strong correlations were observed between informational quality, reasoning performance, and satisfaction. LLMs exhibit significant variability in performance when managing pituitary adenomas. Claude Opus 4.1 demonstrated the highest levels of informational quality, reasoning depth, and expert trust. While LLMs may serve as supportive adjuncts in multidisciplinary pituitary care, structured evaluation and expert oversight remain essential before clinical integration. 2 - Prospective comparative diagnostic accuracy study.
Case Report: Treatment of hypersomatotropism in a diabetic dog with transsphenoidal hypophysectomy.
Pituitary somatotroph adenoma is rare in dogs and may cause hypersomatotropism (HS) leading to insulin resistance and diabetes mellitus (DM). A 10-year-5-month-old neutered male Staffordshire Bull Terrier presented with polyuria, polydipsia, progressive inspiratory stridor, and poorly controlled DM with hyperinsulinemia and insulin resistance. Serum insulin-like growth factor (IGF-1) was markedly elevated (1,214 ng/mL; reference interval, 42-449 ng/mL) and suggested HS which was further supported by a somatostatin suppression test. Magnetic resonance and computed tomography (CT) imaging revealed a pituitary mass, organomegaly, and arthropathy. The pituitary mass was removed by transsphenoidal hypophysectomy. Immunohistochemistry confirmed a growth hormone (GH)-producing pituitary adenoma. Postoperatively, GH normalized within hours, and IGF-1 values within a week. Although HS resolved and hyperinsulinemia improved postoperatively, the dog remained dependent on insulin and DM persisted which eventually led to euthanasia of the dog about 9 and a half months post-operatively. Transsphenoidal hypophysectomy was effective in normalization of GH and IGF-1 concentrations in a dog diagnosed with a pituitary somatotroph adenoma but the postoperative course was characterized by persistent insulin dependency and DM.
Regression of pituitary macroadenoma after endovascular embolization of thoracic cerebrospinal fluid-venous fistula for symptomatic intracranial hypotension: Illustrative case.
Pituitary hyperemia and gland enlargement can be cardinal features of intracranial hypotension secondary to cavernous sinus and epidural venous plexus distention. This phenomenon can therefore complicate radiographic interpretation of sellar lesions when both diagnoses co-exist. We report a unique case of a rapidly enlarging pituitary macroadenoma in the setting of a thoracic cerebrospinal fluid (CSF)-venous fistula causing symptomatic intracranial hypotension. A 53-year-old female with no prior neurosurgical history presented with recurrent orthostatic headache. Magnetic resolution imaging revealed a pituitary lesion along with pathopneumonic signs of intracranial hypotension. The tumor grew rapidly on surveillance imaging, prompting consideration of surgery. Further work-up, however, revealed a thoracic CSF-venous fistula. Endovascular embolization of the fistula led to near-complete resolution of her symptoms and durable radiographic tumor regression. Pituitary macroadenomas are susceptible to local hemodynamic changes occurring as a sequelae of occult CSF leak. Identification and treatment of the underlying etiology were sufficient to induce tumor regression.
Intraoperative Visual Evoked Potential Monitoring in Endoscopic Endonasal Surgery for Nonpituitary Adenoma Suprasellar Tumors.
Intraoperative visual evoked potential (VEP) monitoring has been studied mainly in pituitary adenoma, while its role in nonpituitary suprasellar tumors has remained unclear. This study evaluated the predictive usefulness of intraoperative VEP monitoring during endoscopic endonasal surgery (EES) and aimed to identify optimal alarm criteria for visual outcomes. We retrospectively analyzed a cohort of 87 patients who underwent EES with intraoperative VEP monitoring between April 2021 and September 2023. Visual outcomes were evaluated preoperatively and at short-term (≤3 months) and long-term (12 months) follow-ups, with visual deterioration at these time points defined as worsening of either visual acuity or the visual field. Reductions in the VEP amplitude were quantified using both the maximum intraoperative decrease and the final amplitude after recovery. Receiver operating characteristic (ROC) curve analyses were performed to identify the optimal alarm thresholds, and the sensitivity, specificity, positive predictive value, and negative predictive value were calculated for short-term and long-term visual deteriorations. Short-term and long-term visual deteriorations were detected in 12 (9.2%) and 5 (3.8%) of the 130 analyzed eyes, respectively. ROC curve analyses identified ≥40% and ≥30% reductions in the N75-P100 amplitude as optimal alarm criteria for short-term and long-term visual deteriorations, respectively. A 30% reduction without intraoperative recovery demonstrated markedly higher sensitivity than the conventional 50% alarm threshold for short-term (58.3% vs. 33.3%) and long-term (80.0% vs. 20.0%) outcomes, while maintaining acceptable specificity (82.2% and 80.8%, respectively). A 30% reduction in amplitude represents a more-sensitive and clinically relevant alarm threshold than a 50% reduction for intraoperative VEP monitoring during EES for nonpituitary suprasellar tumors. Incorporating both the magnitude and recovery pattern of VEP amplitude changes may improve the accuracy of predictions of long-term visual deterioration. However, the potential for false positives warrants cautious interpretation, and further studies are needed to validate the impact of intraoperative VEP monitoring on visual outcomes.
Publicações recentes
Systematic Review of the Molecular Basis for Cavernous Sinus Invasion in Somatotropinomas.
Amyloidogenic pituitary prolactinoma.
Selective resection of the medial wall of the cavernous sinus in acromegaly: patient series.
3D volume growth rate may open new perspectives for the classification of aggressive pituitary adenomas.
Challenging the known: unusual case report of acromegaly and subclinical Cushing's disease combination.
📚 EuropePMC3.759 artigos no totalmostrando 197
Integrated proteomic and metabolomic profiling reveals molecular signatures underlying invasiveness in non-functioning pituitary adenomas.
Oncology lettersLong-term trajectories of cognitive function, fatigue, and quality of life in patients after pituitary adenoma surgery: A retrospective study.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of AustralasiaLumbar spinal stenosis in patients with acromegaly: an MRI-based case-control study.
World neurosurgeryAI at the Sella Turcica: Multi-Model Large Language Model Evaluation in Pituitary Adenomas.
Brain & spineNivolumab rechallenge after pituitary apoplexy associated with nivolumab plus ipilimumab in a patient with pituitary adenoma and rectal melanoma: a case report and literature review.
Journal of pharmaceutical health care and sciencesBiochemical and metabolic tissue discrimination using a dual-modality Raman-fluorescence endonasal spectroscopy probe for pituitary adenoma surgery.
PituitaryGyrus Rectus Herniation Following Transsphenoidal Pituitary Adenoma Surgery: A Rare Case Report.
Journal of neurological surgery reportsEarly Experience With Endoscopic Endonasal Transsphenoidal Surgery for Pituitary Adenomas: Clinical Outcomes and Complications.
The Journal of craniofacial surgery[Matrix metalloproteinases in pituitary adenoma invasiveness].
Problemy endokrinologii[Multiple endocrine neoplasia syndrome type 1: analysis of data from 102 patients from 43 families in the population of the Russian Federation].
Problemy endokrinologiiPathogenesis of Non-Familial Somatotroph Adenomas.
The Journal of clinical endocrinology and metabolismHormonal rhythm disturbance is a potential contributor to postoperative cognitive dysfunction of pituitary tumor surgery.
NeuroendocrinologyCoexistence of Intracranial Aneurysm and Pituitary Adenoma: A Case Report and Literature Review.
CureusCase Report: Treatment of hypersomatotropism in a diabetic dog with transsphenoidal hypophysectomy.
Frontiers in veterinary scienceSellar Dermoid Cyst Coexistence with Pituitary Adenoma/Pituitary Neuroendocrine Tumor.
Journal of neurological surgery reportsOxidative phosphorylation patterns in pituitary adenoma/neuroendocrine tumors.
PituitaryQuality of life questionnaires in patients with acromegaly: a scoping review.
Journal of patient-reported outcomesDiagnostic Utility of T-PIT, PIT-1, and SF-1 in Differentiating Pituitary Neuroendocrine Tumors From Sinonasal and Skull Base Tumors.
Applied immunohistochemistry & molecular morphology : AIMMSevere Headache and Acute Blindness: A Case of Pituitary Apoplexy.
Clinical case reportsCrooke Cell Adenoma: Is Its Aggressiveness Overestimated? Evidence From a Single-Centre Experience.
Clinical endocrinologyProteomic insights into the invasiveness and tumor progression of non-functioning pituitary adenomas: A scoping review.
Journal of neuroendocrinologyEvaluation of static and dynamic pupil responses in patients with acromegaly with automatic pupillometer.
BMC ophthalmologyThe clinical value of [18F]-fluoro-ethyl-L-tyrosine PET ([18F]FET-PET) correlated with MRI in patients with functioning pituitary adenomas: an observational cohort study.
PituitaryVariances in 3D radiomic shape features between meningioma, acoustic neuroma, and pituitary adenoma and the impact on dosimetric plan quality in Gamma Knife stereotactic radiosurgery.
Biomedical physics & engineering expressRegression of pituitary macroadenoma after endovascular embolization of thoracic cerebrospinal fluid-venous fistula for symptomatic intracranial hypotension: Illustrative case.
Surgical neurology internationalConjunction of ovarian dermoid cyst in a patient with Pituitary Micro Adenoma: A Case Report.
JNMA; journal of the Nepal Medical AssociationEarly postoperative hyponatremia after pituitary adenoma surgery: risk factors, predictive model, and clinical implications.
BMC endocrine disordersIntraoperative Visual Evoked Potential Monitoring in Endoscopic Endonasal Surgery for Nonpituitary Adenoma Suprasellar Tumors.
Journal of clinical neurology (Seoul, Korea)Isolated Intracranial Rosai-Dorfman Disease Mimicking Sellar Pituitary Adenoma: a case report and literature review.
BMC neurologyOptical coherence tomography angiography reveals microvascular changes and predicts visual outcomes after decompression surgery for pituitary adenoma.
The British journal of ophthalmologyMALAT1 rs619586 as a potential genetic marker of pituitary adenoma susceptibility and aggressiveness.
Frontiers in endocrinologyPituitary Apoplexy Following Gonadotropin-Releasing Hormone Agonist Administration for Prostate Cancer.
IJU case reportsRepeat stereotactic radiosurgery for pituitary adenomas: a systematic review and meta-analysis.
Neurosurgical reviewDNMT3A R882C variant in a patient with a presumed pineal gland tumor, highlighting potential tumor susceptibility in Tatton-Brown-Rahman syndrome.
Cancer geneticsEffect of preoperative anemia on surgical outcomes in endonasal transsphenoidal surgery for pituitary adenoma: a matched-cohort study.
Acta neurochirurgicaMultiple endocrine neoplasia with an atypical clinical course and a MEN1 gene variant of uncertain pathogenicity: A case report.
MedicineXanthomatous hypophysitis with optic chiasm edema: First documented clinical case.
Radiology case reportsCancer Risk in Patients with Acromegaly: Insights from a Single Center in Ankara.
Journal of clinical medicineTwo-Week Interval Hypofractionated Stereotactic Radiosurgery for Benign Intracranial Tumors: Volumetric Kinetics and Radiobiological Rationale.
CancersCDK8 phosphorylates SOX2 to maintain stemness of pituitary adenoma.
OncogeneRedefining Pituitary Neuroendocrine Tumors in MEN1: Prevalence, Clinical Behavior, and Implications for Long-Term Surveillance.
Current oncology (Toronto, Ont.)Differences in clinical course between pituitary apoplexy and non-apoplexy patients with nonfunctioning pituitary neuroendocrine tumors.
Neurosurgical reviewBone microarchitecture assessed by HR-pQCT in syndrome of inappropriate secretion of thyrotropin with thyrotoxicosis.
Archives of osteoporosisA Clival Mass Posing a Diagnostic Challenge: Pituitary Adenoma With Rathke Cleft Cyst Mimicking Chordoma.
CureusMask - Region-based Convolutional Neural Networks (R-CNN) with Radiomics Integration and Gray Level Co-occurrence Matrix (GLCM) for brain tumor detection and segmentation.
PloS oneEfficacy and long-term outcomes of dopamine agonist treatment in prolactinomas.
Best practice & research. Clinical endocrinology & metabolismOridonin regulates pituitary-derived folliculostellate cells apoptosis via the p38 MAPK/p53 signalling pathway.
European journal of pharmacologyAcromegaly presenting with normal insulin-like growth factor-1 levels in a patient with advanced liver cirrhosis.
BMJ case reportsAcromegaly-induced dilated cardiomyopathy presenting with heart failure as the cardinal symptom: A case report.
SAGE open medical case reports[68Ga]Ga-DOTATATE PET/CT and PET/MR enhances the detection of pituitary ACTH-secreting adenomas in cushing's disease.
Frontiers in endocrinologyPredicting resection success in giant pituitary adenomas: morphologic determinants and a preoperative multivariate model.
Frontiers in endocrinologySiCmiR Atlas: Single-Cell miRNA Landscape Reveals Hub-miRNA and Network Signatures in Human Cancers.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)Diffusion-based virtual multi-stain staining for pituitary adenoma histopathology.
Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging SocietyMultiple endocrine neoplasia type 5: emerging evidence and clinical perspectives.
Endocrine-related cancerSurgical outcomes of endoscopic endonasal surgery for nonfunctioning pituitary adenoma in elderly patients: a comprehensive analysis beyond age : Surgery for pituitary adenoma among elderly patients.
BMC endocrine disordersIsolated primary amenorrhea in a 22-year-old female revealing pituitary apoplexy: a rare case report.
Annals of medicine and surgery (2012)[Lost anatomical structure - pharyngeal pituitary gland (Hypophysis pharyngealis or Erdheim pituitary gland): a review and case report].
Zhurnal voprosy neirokhirurgii imeni N. N. BurdenkoA Medically Managed Case of Acromegaly: A Case Report.
CureusHistopathological and radiological predictors of surgical remission failure in GH-secreting pituitary adenomas.
PituitarySubsequent primary malignancies in patients with initial diagnosis of pituitary adenoma: a surveillance, epidemiology, and end results (SEER) data analysis.
PituitarymiR-221/222 Facilitate Pituitary Adenoma Progression Via PHACTR4 Downregulation.
Human mutationEctopic maxillary ACTH-secreting adenoma complicated by Nelson's syndrome: a case report.
Annales d'endocrinologieDRD2 Deficiency Underlies Pituitary Adenoma Dependent on Escherichia coli Translocation from the Gut.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)Sex-related differences in healthcare utilization and costs among patients with pituitary adenomas.
PituitaryThe Use of Indocyanine Green (ICG) in Endoscopic Pituitary Surgery: A Systematic Review.
Neuro-ChirurgieDecoy Lesion in Functional Multiple Pituitary Adenomas: Literature Review and Illustrative Cases on Diagnostic Pitfalls and Surgical Strategies.
World neurosurgeryPostoperative days 1 and 2 morning cortisol levels as predictors of long-term secondary adrenal insufficiency following pituitary adenoma surgery.
Journal of neurosurgeryClinical characteristics associated with somatic GNAS mutations in acromegaly: a systematic review and institutional experience.
Frontiers in endocrinologyImpact of sex on mortality in patients with pituitary adenomas.
PituitaryCoexistence of Resistance to Thyroid Hormone and a Thyroid Stimulating Hormone-Secreting Pituitary Adenoma.
AACE endocrinology and diabetesDisease activity and maternal-fetal outcomes in pregnant women with cushing's syndrome: a systematic review and meta‑analysis.
Reviews in endocrine & metabolic disordersCavernous Sinus Medial Wall Resection: A Retrospective Single-Institution Study on Outcomes in Functional Pituitary Adenomas.
Operative neurosurgery (Hagerstown, Md.)The INVasiveness in Pituitary ADEnomas Score: Development and Validation of a Novel Radiographic Grading Scale for Pituitary Adenoma Invasion.
Operative neurosurgery (Hagerstown, Md.)New Sparks and Spots: Molecular Imaging with Positron Emission Tomography Will Change Management of Cushing's Disease.
Endocrinology and metabolism (Seoul, Korea)Preoperative Metabolic Predictors of Granulation Subtypes in Somatotroph Tumors: A Multicenter Retrospective Cohort Study.
CNS neuroscience & therapeuticsA Case Report of Growth Hormone-Secreting Pituitary Adenoma Complicated by Apoplexy With Atypical Clinical Presentation.
Case reports in medicineLugol's solution for preoperative management of a TSH/GH-secreting pituitary adenoma with suboptimal response to octreotide: a case report.
Frontiers in endocrinologyMixed gangliocytoma-pituitary neuroendocrine tumour: clinical, immunohistochemical, and molecular genetic profiles in a series of four patients.
Acta neuropathologica communicationsOxidative Phosphorylation in Silent Pituitary Adenomas: A Multiomics Perspective.
International journal of endocrinologyA novel germline CDH23 variant as a likely cause of an ultra-giant prolactinoma.
Orphanet journal of rare diseasesOptimizing glioma vascular analysis: A finetuned masked autoencoder self-attention mechanism approach for accurate and interactive blood vessel segmentation.
Revista de investigacion clinica; organo del Hospital de Enfermedades de la NutricionRecurrent Pituitary Adenoma Causing Cushing's Disease in a Patient With Lynch Syndrome.
CureusCritical views for safe surgical phase progression in endoscopic endonasal transsphenoidal pituitary adenoma resection: modified Delphi consensus.
PituitaryLearning Curve in Endoscopic Pituitary Surgery: Is Progress over Time Always Guaranteed? A Consecutive Series of 123 Cases from a Single Center.
Journal of clinical medicineSerum Lipidomic Profile Signature of Active Acromegaly and Relationships to Cardiovascular Disease.
International journal of molecular sciencesCraniofacial and Radiological Features as Diagnostic Clues to Unmask Acromegaly: A Case Report.
CureusComprehensive evaluation and analysis of pituitary hormones in male patients with non-functional pituitary adenoma during the perioperative period.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical NeurophysiologyMachine learning-based models for preoperative prediction of pituitary adenoma consistency: a systematic review and meta-analysis.
Acta neurochirurgicaDiagnosis and surgical management of a pituitary adenoma coexisting with a persistent trigeminal artery: Case report and review of the literature.
NeurocirugiaRadiosurgery in recurrent and persistent Cushing's Disease: a Systematic Review and Meta-Analysis.
Neurosurgical reviewThe International Classification of Diseases for Oncology, 4th Edition (ICD-O-4): An overview.
Cancer epidemiologyAssociation of standard postoperative day 1 discharge following endonasal surgery for pituitary adenoma with lower complication rates and unplanned medical care.
Journal of neurosurgeryThyroid-Stimulating Hormone (TSH)-Secreting Pituitary Macroadenoma Presenting as Biochemical Hyperthyroidism Without Clinical Symptoms: A Case Report.
CureusEctopic Acromegaly Caused by Peripheral Ectopic Growth Hormone Hypersecretion: A Case Report and Literature Review.
CureusAn overview of hypopituitarism's causes.
Frontiers in endocrinologyWidespread invasion of a giant prolactinoma via valveless venous channels: illustrative case.
Journal of neurosurgery. Case lessonsCollision tumors at the skull base: unveiling a somatotroph pituitary adenoma coexisting with a petroclival meningioma. Illustrative case.
Journal of neurosurgery. Case lessonsUtility of standardized T2-weighted MRI intensity ratio for prediction of pituitary macroadenoma consistency.
Journal of neurosurgeryGender differences in the glycometabolic and cardiovascular features of acromegaly.
PituitaryAn Investigation of the Effect of Exercise on Sleep Disturbances and Fatigue Symptoms in Patients Diagnosed with Primary Brain Tumors: A Systematic Review.
NeuroSciGut microbiota composition and functionality are associated with prolactin-secreting pituitary adenoma and serum lipid levels.
BMC microbiologyLong-term effect on bone mineral density of denosumab in the treatment of hyperpituitarism driven osteoporosis: an exploratory study.
PituitaryClinical characteristics and risk factors of delayed ophthalmoplegia following cavernous sinus exploration in endoscopic pituitary adenoma surgery : Delayed transient ophthalmoplegia.
PituitaryNormal Pituitary Gland Showing an Intratumoral Septal Structure in a Nonfunctioning Pituitary Neuroendocrine Tumor: Illustrative Case.
NMC case report journalSeeing the unseen: A case series of intracranial mass lesions initially presenting with visual disturbances.
The Journal of international medical research[Corrigendum] CDKN2A (p16INK4A) affects the anti‑tumor effect of CDK inhibitor in somatotroph adenomas.
International journal of molecular medicineSellar and parasellar paraganglioma mimicking pituitary macroadenoma in a young female: A rare case report.
International journal of surgery case reportsSex and Age Differences in Transcription Factor and Hormonal Immunostaining in Patients With Nonfunctioning Pituitary Adenomas.
Operative neurosurgery (Hagerstown, Md.)Cabergoline monotherapy in GH- and PRL-cosecreting pituitary adenomas.
Endocrine oncology (Bristol, England)Pituitary apoplexy in the setting of adrenocorticotropic hormone-secreting adenoma: A systematic review and illustrative case.
Brain circulationEndoscopic Transsphenoidal Approach for the Treatment of Pituitary Adenoma Complicated With Rathke Cleft Cyst.
The Journal of craniofacial surgeryHistogram analysis based on contrast-enhanced T1-weighted imaging in pituitary macroadenomas: relation to histological subtype and expression.
Quantitative imaging in medicine and surgery"Doughnut appearance" of macular microcysts due to optic atrophy on optical coherence tomography angiography.
Retinal cases & brief reportsClinicopathological features and outcomes in non-functioning pituitary neuroendocrine tumors: a transcription factor-driven subtype analysis.
Journal of neuro-oncologyIsolated Adrenocorticotropic Hormone Deficiency:Report of Three Cases and Literature Review.
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae SinicaeRace and Cerebrospinal Fluid Leaks: Concerning Associations after Endonasal Transsphenoidal Pituitary Resection.
Journal of neurological surgery. Part B, Skull baseThe Impact of Extended Procedure Duration on Nasal Morbidity after Endoscopic Endonasal Transsphenoidal Resection of Pituitary Macroadenomas.
Journal of neurological surgery. Part B, Skull basePrimary Bilateral Macronodular Adrenal Hyperplasia Associated With ARMC5 Variant and Pituitary Microadenoma.
JCEM case reportsAssociation between the WHO 2017 and 2022 classification updates and ICD-10 code accuracy in patients with PitNETs: a real-world retrospective study.
BMC endocrine disordersAcromegaly in an elderly male with hepatic malignancy: a case report of a diagnostic dilemma.
Annals of medicine and surgery (2012)Surgical and Endocrine Outcomes of Medial Cavernous Sinus Wall Resection in Functioning Pituitary Tumors.
Operative neurosurgery (Hagerstown, Md.)Case Reports: Exploring the Varied Presentations and Clinical Features of Carney Complex, A Detailed Report on Three Distinct Cases.
Journal of clinical research in pediatric endocrinologyCorrelation between intrasellar pressure, pituitary adenoma invasiveness, pituitary dysfunction, and apoplexy.
Frontiers in endocrinologyPhenotypic and functional characteristics of pituitary adenoma stem cells.
World journal of clinical casesMultiple Endocrine Neoplasia Type 5 due to Germline MAX Mutations: A Systematic Review of Tumor Spectrum and Clinical Features.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical EndocrinologistsSerum Kynurenine Pathway Metabolites as Candidate Diagnostic Biomarkers for Pituitary Adenoma: A Case-Control Study.
Medicina (Kaunas, Lithuania)Mixed gangliocytoma-silent somatotroph pituitary adenoma: a rare variant with pregnancy-associated growth.
BMJ case reportsFrom proliferation to bone invasion: The association between Ki-67 index and histological Sellar floor destruction in pituitary adenomas.
EndocrineGlucocorticoid-Induced Positive Feedback in Cushing Disease: Insights From a Spanish Multicenter Cohort.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical EndocrinologistsThe surgical management of Cushing disease: a case series from a Canadian tertiary center.
Neurological researchStrong PSMA Expression by a Pituitary Macroadenoma on PSMA PET/CT.
Clinical nuclear medicineEarly Experience of Endoscopic Endonasal Transphenoidal Surgery in the Democratic Republic of Congo: Expanding Access to Skull Base Oncology.
CureusPredictive model of delayed hyponatremia after endoscopic endonasal transsphenoidal resection of pituitary adenoma.
Frontiers in human neuroscienceDuration of adrenal insufficiency after surgical treatment of endogenous hypercortisolism: a prospective cohort study.
European journal of endocrinologySurgical management in very elderly patients with pituitary adenoma: a multivariable assessment of the surveillance, epidemiology, and end results database.
PituitaryProspective Observational Study of 118 Clinically Nonfunctioning Pituitary Adenomas.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical EndocrinologistsFunctional analysis of AIP variants in a cohort of neuroendocrine neoplasms.
Endocrine-related cancerRevealing sphingolipid metabolism genes as biomarkers for the diagnosis of invasive pituitary adenomas in silico and in vivo.
European journal of medical researchAnatomical considerations in acromegalic patients: A multicentric cohort study.
Surgical neurology internationalPredictors of delayed hyponatremia after endoscopic transsphenoidal surgery for non-functioning pituitary adenomas.
Frontiers in endocrinologyRadiological Differentiation of Pituitary Adenomas From Other Sellar Masses: A Systematic Review.
CureusThe efficacy of minimally invasive intraoperative ultrasound in endoscopic pituitary surgery.
PituitaryA new method for repairing internal carotid artery rupture in skull base surgery: a case report and review of the literature.
Frontiers in surgeryRapid Endocrine Remission After ZAP-X Gyroscopic Radiosurgery for Cushing's Disease: A Case Report.
CureusClival Infiltrative Lesions: A Review of Differential Diagnosis Illustrated by a Rare Case of Coexisting Invasive Pituitary Adenoma and Clival Intravascular Lymphoma.
Journal of the Belgian Society of RadiologyStructural and Functional Outcomes of Optic Pathway Compression in Pituitary Adenoma: A Prospective Pilot OCT Study.
Clinical ophthalmology (Auckland, N.Z.)A case report of atypical teratoid/rhabdoid tumor and pituitary adenoma collision tumor in the sellar region.
Frontiers in surgeryRebirth of an old modality: revisiting intraoperative ultrasound in pituitary surgery.
PituitaryFrom misclassified AIP variant to carney complex: a case report and retrospective evaluation of PRKAR1A in pituitary tumor predisposition.
PituitaryValidation and modification of the PANOMEN 3 classification for predicting long-term recurrence/progression and quality of life in patients with pituitary adenomas: a multicentre retrospective cohort study.
PituitaryAnemia in acromegaly: Prevalence, etiologies, and predictors from a large tertiary center cohort.
PituitarySpontaneous regression of a growth hormone-secreting pituitary adenoma following thyroidectomy for toxic multinodular goiter with superior vena cava obstruction: Report of a rare case.
Medicine internationalRadiomics-based multiple machine learning approaches for investigating medial wall invasion of the cavernous sinus in pituitary adenomas.
Frontiers in oncologyMore Than a Headache: Unveiling Pituitary Apoplexy Following Acute Coronary Syndrome.
CureusUltrasound-Guided Jugular Vein Access for Inferior Petrosal Sinus Sampling: A Safe and Feasible Technique.
CureusOsteoporosis and fragility fractures in patients with acromegaly: A two-center cross-sectional study.
World journal of orthopedicsCAF-derived exosomes promote the proliferation and invasion of pituitary adenoma cells via miR-184 transfer.
Brain research bulletinReal-world burden of disease, treatment, and healthcare resource utilization in acromegaly: a quantitative survey of patient experiences.
Journal of patient-reported outcomesDual Hormonal Presentation in a Rare Sellar Gangliocytoma: Diagnostic and Pathological Insights from a Collision Tumor.
Journal of neurological surgery reportsPotentially radiation-induced late toxicity after irradiation of pituitary adenoma, a retrospective dosimetric study.
Radiation oncology (London, England)The Mystery of Elevated β-hCG in GnRH-Independent Precocious Puberty without a Detectable Tumor: A Six-Year Diagnostic Odyssey.
Hormone research in paediatricsDeciphering USP8's pivotal role in cancer: mechanisms, clinical insights and contrasts with its function in pituitary adenomas.
Journal of translational medicineClinical, radiological, and pathological characteristics and long-term outcomes of silent corticotroph adenomas: a retrospective study.
BMC endocrine disordersPatient perceptions of pituitary incidentaloma diagnosis and follow-up: a Pituitary Society international patient survey.
PituitaryPituitary tuberculosis in the pediatric population: a systematic review and case report.
PituitaryTrends of hospital-based reporting of intracranial neoplasms in Nigeria from 1960 to 2024: A systematic review and pooled analysis of literatures.
Neuro-oncology advancesHigh-Risk Prostate Cancer in a Patient with Untreated Prolactinoma and Castrate-Level Testosterone Suppression: A Case Report.
Case reports in oncologyGiant Prolactinoma Resistant to High-Dose Cabergoline in a Young Male Lost to Follow-Up.
CureusKi-67 and Preoperative Hypocortisolism are Predictive Factors for Postoperative Diabetes Insipidus After Endoscopic Pituitary Tumor Resection.
World neurosurgeryTumor characteristics and clinical outcomes in 113 patients with acromegaly: exploratory analysis of the role of histologic invasion of adjacent tissues.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of AustralasiaVery Long-Term Follow-Up of Multidimensional Health-Related Quality of Life After Endoscopic Endonasal Surgery for Pituitary Adenomas: A Prospective Cohort Study.
Head & neckCase Report: Management of a pregnancy complicated by a symptomatic macroprolactinoma.
Frontiers in medicineTherapeutic challenges of giant invasive cystic macroprolactinoma.
Endocrinology, diabetes & metabolism case reportsPituitary hormone deficiencies in prolactinomas: prevalence, predictors, and functional recovery.
Frontiers in endocrinologyAcromegaly and breast cancer risk: evidence from a systematic review and meta-analysis.
Frontiers in endocrinologyTransformation of Lactotroph Pituitary Adenoma to Metastatic Pituitary Carcinoma: A Case Report.
CureusUnusual Presentation of Hypopituitarism Caused by Internal Carotid Artery Aneurysm.
CureusA case of recurrent Cushing's disease with optimised perinatal outcomes.
Endocrinology, diabetes & metabolism case reportsDevelopment of a Novel Interpretable Transformer-Based Deep Learning Model for Predicting Postoperative Hypokalemia in Pituitary Adenomas.
Journal of evidence-based medicineMicroarchitecture of the cavernous sinus walls: Clinical implications for pituitary adenomas.
Tissue & cellImmunohistochemical analysis of filamin a expression in acromegaly and its correlation with tumor characteristics and treatment response.
Scientific reportsPituitary Gland Metastases As the Initial Presentation of Lung Adenocarcinoma: A Case Report.
CureusSevere Primary Hypothyroidism in a Child Presenting as a Pituitary Tumour: A Case Report.
CureusRisk factors and predictive model for postoperative cerebrospinal fluid leakage following endoscopic endonasal pituitary adenoma surgery: a retrospective study focusing on pneumocephalus and sellar floor bony window.
Frontiers in endocrinologyEvaluation of ChatGPT as a supplementary tool for pituitary adenomas: An observational study based on simulated consultations.
MedicineLoss of heterozygosity and absence of MAX immunostaining in a prolactinoma associated with multiple endocrine neoplasia type 5 (MEN5).
PituitaryIncidence and risk factors for transient and permanent central diabetes insipidus following pituitary adenoma surgery: a single center study.
The International journal of neuroscienceCase Report: Bilateral lens dislocation as an atypical presentation of acromegaly and review of the ocular effects of GH/IGF-1 excess.
Frontiers in endocrinology[Consensus on the diagnosis and treatment of pituitary prolactinoma (2025 edition)].
Zhonghua yi xue za zhi[Refractory pituitary prolactinoma:current treatment status and challenges].
Zhonghua yi xue za zhiProposed algorithm for early postoperative evaluation after endonasal endoscopic resection of pituitary adenomas with suprasellar extension.
Surgical neurology internationalBreast Cancer Metastasis to the Pituitary Presenting With Apoplexy.
CureusEpidemiology, presentation and outcomes in pituitary apoplexy: a population-based study in Malta.
Endocrine oncology (Bristol, England)Radiolabeling molecular biomarkers of invasive pituitary adenomas: a narrative review.
PituitaryIncidence and characterization of spontaneous pituitary neuroendocrine tumors in aged spontaneously hypertensive rats.
Scientific reportsMultiparameter MRI-based clinical-radiomic model to differentiate prolactinoma from hyperprolactinemic nonfunctioning pituitary adenoma.
Journal of neurosurgeryManagement of a mixed ACTH- and prolactin-secreting pituitary adenoma during pregnancy.
Endocrinology, diabetes & metabolism case reportsAssociações
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Long-term trajectories of cognitive function, fatigue, and quality of life in patients after pituitary adenoma surgery: A retrospective study.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia· 2026· PMID 41864128mais citado
- AI at the Sella Turcica: Multi-Model Large Language Model Evaluation in Pituitary Adenomas.
- Case Report: Treatment of hypersomatotropism in a diabetic dog with transsphenoidal hypophysectomy.
- Regression of pituitary macroadenoma after endovascular embolization of thoracic cerebrospinal fluid-venous fistula for symptomatic intracranial hypotension: Illustrative case.
- Intraoperative Visual Evoked Potential Monitoring in Endoscopic Endonasal Surgery for Nonpituitary Adenoma Suprasellar Tumors.
- Systematic Review of the Molecular Basis for Cavernous Sinus Invasion in Somatotropinomas.
- Amyloidogenic pituitary prolactinoma.
- Selective resection of the medial wall of the cavernous sinus in acromegaly: patient series.
- 3D volume growth rate may open new perspectives for the classification of aggressive pituitary adenomas.
- Challenging the known: unusual case report of acromegaly and subclinical Cushing's disease combination.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:99408(Orphanet)
- MONDO:0006373(MONDO)
- GARD:19680(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
- Q864296(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
