Um tumor benigno na glândula hipófise, que produz hormônios e está associado a um conjunto de problemas causados por esses hormônios.
Introdução
O que você precisa saber de cara
Um tumor benigno na glândula hipófise, que produz hormônios e está associado a um conjunto de problemas causados por esses hormônios.
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 92 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 219 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
7 genes identificados com associação a esta condição.
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for norma
Cell membrane
Usher syndrome 1D
USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa with sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH1 is characterized by profound congenital sensorineural deafness, absent vestibular function and prepubertal onset of progressive retinitis pigmentosa leading to blindness.
Receptor for glucocorticoids (GC) (PubMed:27120390, PubMed:37478846). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (PubMed:28139699). Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of ta
CytoplasmNucleusMitochondrionCytoplasm, cytoskeleton, spindleCytoplasm, cytoskeleton, microtubule organizing center, centrosomeChromosomeNucleus, nucleoplasm
Glucocorticoid resistance, generalized
An autosomal dominant disease characterized by increased plasma cortisol concentration and high urinary free cortisol, resistance to adrenal suppression by dexamethasone, and the absence of Cushing syndrome typical signs. Clinical features include hypoglycemia, hypertension, metabolic alkalosis, chronic fatigue and profound anxiety.
Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling
NucleusChromosome, telomereNucleus, PML body
Alpha-thalassemia/impaired intellectual development syndrome, X-linked
A disorder characterized by severe psychomotor retardation, facial dysmorphism, urogenital abnormalities, and alpha-thalassemia. An essential phenotypic trait are hemoglobin H erythrocyte inclusions.
Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179)
NucleusCytoplasmCell membrane
Deubiquitinase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of polyubiquitin precursors as well as that of ubiquitinated proteins (PubMed:16214042, PubMed:34059922). Plays a role in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites. Plays an important role in cell cycle progression by deubiquitinating Aurora B/AURKB an
CytoplasmNucleusCell projection, cilium
Deafness, autosomal dominant, 85
A form of non-syndromic, sensorineural hearing loss. Sensorineural hearing loss results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA85 is characterized by progressive hearing loss, with onset in childhood or young adulthood.
Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:35618207, PubMed:36634798, PubMed:38653238, PubMed:9840937). Acts as a tumor suppressor in many tumor types; induces growth arrest or apop
CytoplasmNucleusNucleus, PML bodyEndoplasmic reticulumMitochondrion matrixCytoplasm, cytoskeleton, microtubule organizing center, centrosome
Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates t
CytoplasmNucleusEndosome membraneCell membrane
Pituitary adenoma 4, ACTH-secreting
A form of pituitary adenoma, a neoplasm of the pituitary gland and one of the most common neuroendocrine tumors. Pituitary adenomas are clinically classified as functional and non-functional tumors, and manifest with a variety of features, including local invasion of surrounding structures and excessive hormone secretion. Functional pituitary adenomas are further classified by the type of hormone they secrete. PITA4 results in excessive production of adrenocorticotropic hormone. This leads to hypersecretion of cortisol by the adrenal glands and ACTH-dependent Cushing syndrome. Clinical manifestations of Cushing syndrome include facial and truncal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes.
Variantes genéticas (ClinVar)
3,975 variantes patogênicas registradas no ClinVar.
Vias biológicas (Reactome)
62 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Adenoma hipofisário funcional
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Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
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Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
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Outros ensaios clínicos
6 ensaios clínicos encontrados, 1 ativos.
Publicações mais relevantes
The clinical value of [18F]-fluoro-ethyl-L-tyrosine PET ([18F]FET-PET) correlated with MRI in patients with functioning pituitary adenomas: an observational cohort study.
To assess the clinical value of [18F]fluoroethyl-L-tyrosine PET ([18F]FET-PET) correlated with MRI in patients with functioning pituitary adenoma (FPA) with negative or equivocal conventional MRIs during diagnosis, persistent disease and recurrence. Retrospective observational cohort study of 34 patients with FPAs who underwent a total of 37 [18F]FET-PETs (Cushing’s disease: n = 19, acromegaly: n = 14, prolactinoma: n = 3, and TSH producing adenoma: n = 1) between January 2022 and April 2025. The clinical performance was assessed in the surgically treated cohort, using confirmative histopathology and/or postoperative remission as reference standard. [18F]FET-PET identified a single lesion in 28 scans (76%), two lesions in 1 scan (3%), and no lesion in 8 scans (22%). [18F]FET-PET and MRI were concordant positive in 14/37 scans, concordant negative in 1/37, discordant MRI+/[18F]FET-PET + different location in 2/37, discordant MRI-/[18F]FET-PET + in 8/37, discordant MRI+/[18F]FET-PET- in 7/37 and partly concordant in 5/37 scans. In 14 cases surgery resulted in confirmative histopathology and/or postoperative remission, 12 of those had a positive [18F]FET-PET. In 6 cases surgery did not result in confirmative histopathology and/or postoperative remission, of whom 5 had a positive [18F]FET-PET. Overall, the sensitivity was 86% and the positive predictive value 71%. In three patients with acromegaly, [18F]FET-PET was able to localize a lesion, despite biochemical control under continued somatostatin analogue treatment. [18F]FET-PET enhances lesion detection and improves personalized treatment in patients with FPA and negative or equivocal conventional MRIs throughout the disease course. Consensus on the timing of [18F]FET-PET with respect to medication and biochemical status is warranted. The online version contains supplementary material available at 10.1007/s11102-025-01634-w.
Oridonin regulates pituitary-derived folliculostellate cells apoptosis via the p38 MAPK/p53 signalling pathway.
Treatment of non-functioning pituitary adenoma remains challenging owing to a lack of effective pharmacological therapies. A previous study has shown that oridonin (ORI) induces apoptosis in pituitary-derived folliculostellate (PDFS) cells; therefore, this study further investigated the molecular mechanisms by which ORI-mediated regulates apoptosis in PDFS cells. To confirm the regulatory role of the p38 mitogen-activated protein kinase (MAPK)/p53 signalling pathway, molecular docking and the p38 MAPK inhibitor SB202190 were used to evaluate pathway modulation. Effects on cell viability, migration, invasion, and apoptosis were evaluated using Calcein-AM/Propidium Iodide (PI) double staining, Transwell migration and invasion assays, and Western blot analysis. To further assess the in vivo effects of ORI, a subcutaneous xenograft model in nude mice was established, and ORI was administered at 5 and 10 mg/kg to assess therapeutic efficacy and safety. Safety was evaluated by analysing histopathological changes in major organs using haematoxylin-eosin (H&E) staining. Western blot analysis of tumour tissues was conducted to assess activation of the p38 MAPK/p53 pathway and the expression of apoptosis-related proteins. Molecular docking and Western blot assays confirmed that ORI binds to p38 protein with an affinity of -7.3 kcal/mol, markedly increasing p38 phosphorylation and p53 expression. The p38 MAPK inhibitor SB202190 reversed ORI-induced effects on cell death, cell migration and invasion, and apoptosis, highlighting the critical role of the p38 MAPK/p53 pathway. ORI effectively suppressed subcutaneous tumour growth in nude mice without notable toxicity while upregulating apoptosis-related proteins Bax and cleaved caspase-3 and downregulating Bcl-2 through activation of the p38 MAPK/p53 pathway.
Sex-related differences in healthcare utilization and costs among patients with pituitary adenomas.
To systematically summarize and evaluate the current evidence regarding sex-based differences in healthcare utilization (HCRU), direct costs, and indirect socioeconomic burden in patients with pituitary adenomas. A systematic literature search of PubMed, EMBASE, and Web of Science identified studies reporting HCRU and/or cost data with sex-stratified analyses. Studies focusing on drug-specific cost-effectiveness, case reports, and scenario-based models were excluded. Eight studies met the inclusion criteria, including non-functioning pituitary adenoma, prolactinoma, acromegaly, Cushing's disease (CD), and perioperative pituitary tumor cohorts from Europe and the United States. Findings were synthesized narratively due to methodological heterogeneity and the scarcity of sex-specific cost estimates. Total and surgical costs did not differ between men and women across most settings in Europe. Only one U.S. acromegaly cohort showed lower adjusted annual costs in women, and one Chinese perioperative patient cohort reported lower inpatient charges among women. In contrast, sex-based differences in HCRU were consistent and clinically relevant: women with acromegaly demonstrated longer diagnostic delays, more pre-diagnostic visits, higher specialist engagement, and more treatment modifications. Perioperatively, sex was not a predictor of length of stay or cost, but several cohorts reported higher rates of cerebrospinal fluid leak, arginine-vasopressin deficiency, and late hyponatremia in women. The most pronounced disparity was observed in indirect socioeconomic burden, with women more frequently experiencing reduced work capacity, early retirement, psychosocial distress, and poorer quality-of-life in acromegaly and CD. Although sex-based differences in overall healthcare costs are limited, women face a disproportionately complex and burdensome care trajectory. Standardized, value-based care pathways may help mitigate these disparities, underscoring the need for prospective, sex-stratified studies.
Decoy Lesion in Functional Multiple Pituitary Adenomas: Literature Review and Illustrative Cases on Diagnostic Pitfalls and Surgical Strategies.
Multiple pituitary adenomas (MPA), particularly those involving functioning adenoma, represent a special subtype of pituitary adenomas that pose dual challenges in diagnosis and treatment. In this setting, the coexistence of hormonally active and silent lesions may result in a diagnostic pitfall when a radiologically dominant tumor does not correspond to the hormonally responsible lesion. This misleading lesion, often referred to as decoy lesion, can adversely influence surgical decision-making in patients with MPA. We systematically reviewed English-language case reports of multiple pituitary adenomas published between 2000 and 2024 in PubMed, Web of Science, and Embase and present 2 illustrative cases. Lesions were classified as responsibility lesions or decoy lesions based on an operational definition incorporating endocrine outcomes, radiological features, and surgical findings. A total of 35 patients from 24 case reports met the inclusion criteria. The mean age was 40 years, with 12 male and 23 female patients. The most common clinical manifestations were acromegaly (n = 13, 37%) and Cushing's syndrome (n = 11, 31%). Our findings indicate that, compared with decoy lesions, responsibility lesions are less conspicuous on preoperative MRI and usually smaller in size. Overall, 43% of these patients (15/35) did not achieve biochemical remission after the initial surgery, with missed identification of the responsibility lesion reported in a substantial proportion of cases. Identifying decoy lesion and distinguishing it from responsibility lesion may improve surgical planning and endocrine outcomes in complex MPA cases.
Cavernous Sinus Medial Wall Resection: A Retrospective Single-Institution Study on Outcomes in Functional Pituitary Adenomas.
Surgery remains first-line therapy for most functioning pituitary adenomas (FPA). Remission rates are lower in some patients due to cavernous sinus invasion. Medial wall resection (MWR) may improve biochemical remission but remains largely underutilized. Our objective is to assess outcomes of MWR in patients with FPA at Oregon Health & Science University performed by a single neurosurgeon. Retrospective, Institutional Review Board-approved study: patients ≥18 years, FPA after MWR with ≥ 3-months follow-up. Remission: normal prolactin, insulin-like growth factor-1, and either adrenal insufficiency or normal cortisol at 3 months for prolactinoma, acromegaly and Cushing disease (CD), respectively. Arginine vasopressin deficiency (AVP-D) defined as needing desmopressin at the last follow-up. Logistic regression identified predictors of biochemical remission. Sixty-four patients, mean age 41.2 years and adenoma size 12.6 mm; CD (39.1%), prolactinoma (37.5%), acromegaly (23.4%). Knosp grade 0 (31.2%), 1 (32.81%), 3 (14%) and 4 (12.5%). Overall remission rate was 82.8%, CD (92%), prolactinoma (87.5%), and acromegaly (60%). Acromegaly (odd ratio 0.035, 95% CI [0.0034, 0.345], P = .004) compared with CD and tumor size (odd ratio 0.87 per mm increase, 95% CI 0.79-0.96, P = .007) were negative predictors of remission. The mean operative time showed significant increase in Crooke (357 ± 128 minutes) vs non-Crooke corticotroph (243 ± 39.7 minutes, P = .012, 95% CI [14.9, 213]), lactotroph (243.1 ± 65.1 minutes, P = .009, 95% CI [17.2, 210.5]), or somatotroph (232.5 ± 45.8 minutes, P = .031, 95% CI [5.9, 243.1]) tumors. Complications include new hypopituitarism (9.4%): adrenal insufficiency 12.8% (prolactinoma and acromegaly), hypothyroidism (1.5%), hypogonadism (1.5%); arginine vasopressin deficiency (20.3%), and transient syndrome of inappropriate antidiuretic hormone (4.7%), 1 cerebrospinal fluid leak and carotid injury (1.5%) repaired with direct coagulation without neurological sequelae. MWR is safe and effective for the surgical management of FPA, particularly in CD and prolactinomas. Despite a steep learning curve, the high remission rates, and low complications support its use in well-selected patients by experienced multidisciplinary teams.
Publicações recentes
Hypogonadotropic Hypogonadism Before and After Transsphenoidal Surgery for Non-Functioning Pituitary Adenoma.
The impact of a non-functioning pituitary adenoma on life - A qualitative study of patients' experiences.
The clinical value of [(18)F]-fluoro-ethyl-L-tyrosine PET ([(18)F]FET-PET) correlated with MRI in patients with functioning pituitary adenomas: an observational cohort study.
Oridonin regulates pituitary-derived folliculostellate cells apoptosis via the p38 MAPK/p53 signalling pathway.
Sex-related differences in healthcare utilization and costs among patients with pituitary adenomas.
📚 EuropePMC150 artigos no totalmostrando 197
The clinical value of [18F]-fluoro-ethyl-L-tyrosine PET ([18F]FET-PET) correlated with MRI in patients with functioning pituitary adenomas: an observational cohort study.
PituitaryOridonin regulates pituitary-derived folliculostellate cells apoptosis via the p38 MAPK/p53 signalling pathway.
European journal of pharmacologySex-related differences in healthcare utilization and costs among patients with pituitary adenomas.
PituitaryDecoy Lesion in Functional Multiple Pituitary Adenomas: Literature Review and Illustrative Cases on Diagnostic Pitfalls and Surgical Strategies.
World neurosurgeryImpact of sex on mortality in patients with pituitary adenomas.
PituitaryCavernous Sinus Medial Wall Resection: A Retrospective Single-Institution Study on Outcomes in Functional Pituitary Adenomas.
Operative neurosurgery (Hagerstown, Md.)Sex and Age Differences in Transcription Factor and Hormonal Immunostaining in Patients With Nonfunctioning Pituitary Adenomas.
Operative neurosurgery (Hagerstown, Md.)Clinicopathological features and outcomes in non-functioning pituitary neuroendocrine tumors: a transcription factor-driven subtype analysis.
Journal of neuro-oncologyClinical, radiological, and pathological characteristics and long-term outcomes of silent corticotroph adenomas: a retrospective study.
BMC endocrine disorders[Refractory pituitary prolactinoma:current treatment status and challenges].
Zhonghua yi xue za zhiManaging Atopic Dermatitis with Dupilumab in Special Populations: A Case Series Study.
Clinical, cosmetic and investigational dermatologyIntensity-Modulated Proton Therapy for an Unresectable Giant Non-functioning Pituitary Adenoma: A Case Report and Literature Review.
CureusNeurocognitive evaluation of patients with non-functioning pituitary adenoma.
PituitaryThe association between sleep quality and cognitive function in patients with non-functioning pituitary adenoma.
Endocrine connectionsAutoimmune thyroid disease and pituitary adenoma in a female patient with 18p deletion syndrome: a case report and review of the literature.
BMC endocrine disordersIsolated syndrome of inappropriate antidiuresis (SIAD) after Transphenoidal surgery of a non-functioning pituitary adenoma: clinical case report.
Oxford medical case reportsCongress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines for the Role of Imaging for Patients With Functioning Pituitary Adenomas.
NeurosurgeryCongress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines for the Role of Radiosurgery for Patients With Functioning Pituitary Adenomas.
NeurosurgeryAnemia in Patients With Pituitary Adenomas: Prevalence and Correlation With Hypopituitarism.
CureusVenous thromboembolism in patients with pituitary adenoma: UK multicentre cohort study.
European journal of endocrinologyEEA for sellar chodrosarcomas: case series with literature review.
Chinese neurosurgical journalBaseline testosterone levels as a predictor of hypogonadism resolution in male patients with isolated hyperprolactinemia.
PituitaryPANOMEN-3 grading score is reliable in predicting pituitary adenoma behavior and prognosis: a single center cohort study.
EndocrineHeadache as an indication for surgery in non-functioning pituitary adenoma and Rathke's cleft cyst: A systematic review.
Clinical neurology and neurosurgerySoluble alpha klotho-impact of biological variables and reference intervals for adults.
European journal of endocrinologyCognitive function and fatigue before and after transsphenoidal surgery in patients with pituitary adenoma: a prospective study.
PituitaryConservatively managed non-functioning pituitary macroadenomas-cohort study from the UK Non-functioning Pituitary Adenoma Consortium.
European journal of endocrinologyMetformin induces apoptosis in pituitary-derived folliculostellate cells via the IL-6/ERK pathway.
Discover oncologyImpulse control disorders in patients with pituitary adenoma managed with or without dopamine agonists: a cross-sectional study from a UK centre.
PituitaryIncidental High-Grade Sellar Solitary Fibrous Tumor Mimicking Non-Functioning Pituitary Adenoma: A Case Report and Literature Review.
The American journal of case reportsCoexisting Non-functioning Pituitary Macroadenoma and Sellar-Suprasellar Lipoma: A Case Report and Literature Review.
Acta medica PhilippinaEtiology, presentation, and outcomes of hyperprolactinemia due to pituitary masses in children and adolescents.
EndocrinePerson-centered support for patients with a pituitary tumor following surgery.
Endocrine connectionsKnosp and revised Knosp classifications predict non-functioning pituitary adenoma outcomes: a single tertiary center experience.
Journal of medicine and lifeA case of non-functioning pituitary adenoma with calcification.
Asian journal of surgeryQuality of life in non-functioning pituitary adenoma: A systematic review.
Neurosurgical reviewCognitive decline in Cushing's syndrome: A systematic review.
Journal of neuroendocrinologyComparative mortality in pituitary adenomas subtypes: a tertiary referral center study.
EndocrineBrain Arteriovenous Malformation Hemorrhage and Pituitary Adenoma in a COVID-19-Positive Patient.
CureusPhenotypic presentation of MEN1 c.758delC (p.Ser253Cysfs *28) pathogenic variant: a case report.
Oxford medical case reportsSZ-685C inhibits the growth of non-functioning pituitary adenoma by down-regulating miR-340-3p and inducing autophagy.
HeliyonPituitary apoplexy: a comprehensive analysis of 93 cases across functioning and non-functioning pituitary adenomas from a single-center.
PituitaryLanreotide versus placebo for tumour reduction in patients with a 68Ga-DOTATATE PET-positive, clinically non-functioning pituitary macroadenoma (GALANT study): a randomised, multicentre, phase 3 trial with blinded outcome assessment.
The Lancet regional health. EuropeAmerican Association of Neurological Surgeons/Congress of the Neurological Surgeons Section on Tumors Guidelines: Assessing Their Impact on Brain Tumor Clinical Practice.
NeurosurgeryDifferential expression of cancer-related lncRNAs in different subtypes of pituitary adenomas.
Pathology, research and practiceStem cell-associated transcription factors in non-functioning pituitary neuroendocrine tumours.
Free neuropathologyCardiovascular risk in patients with acromegaly vs. non-functioning pituitary adenoma following pituitary surgery: an active-comparator cohort study.
PituitaryHigh prevalence of morphometric vertebral fractures opportunistically detected on thoracic radiograms in patients with non-functioning pituitary adenoma.
PituitaryGiant Clinically Non-Functioning Pituitary Adenoma Presenting as New Onset Generalized Tonic‒Clonic Seizures: A Case Report.
International medical case reports journalMagnetic Resonance Imaging Features of the Sphenoid Sinus in Patients with Non-Functioning Pituitary Adenoma.
Medicina (Kaunas, Lithuania)Headache in patients with non-functioning pituitary adenoma before and after transsphenoidal surgery - a prospective study.
PituitaryClinical and radiographic characteristics of patients with non-functioning pituitary adenomas categorized according to their serum prolactin concentration: novel predictors of postoperative transient diabetes insipidus following surgery.
EndocrineMedical and Surgical Approaches for a Non-functioning Pituitary Adenoma During Pregnancy.
CureusExcess mortality in patients with non-functioning pituitary adenoma: a systematic review and meta-analysis.
Journal of endocrinological investigationEndoscopic Endonasal Trans-Sphenoidal Minimally Invasive Pituitary Surgery with Image Guided Navigation System (Igns): Learning Experience of Ent Surgeon: First Author.
Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of IndiaUnique case of lymphocytic hypophysitis with normal pituitary hormone serology mimicking a non-functioning pituitary adenoma.
BMC endocrine disordersSurveillance Imaging Strategies for Pituitary Adenomas: When, How Frequent, and When to Stop.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical EndocrinologistsPerioperative growth hormone levels as an early predictor of new-onset secondary adrenal insufficiency following transsphenoidal pituitary tumor resection.
Asian journal of surgeryThe correlation among Claudin-9, Tyrosine kinase-2, and Signal transducers and activators of transcription-3 expressions in non-functioning pituitary adenoma and invasiveness.
Neuro endocrinology lettersCabergoline treatment for surgery-naïve non-functioning pituitary macroadenomas.
PituitaryVisual acuity in patients with non-functioning pituitary adenoma: Prognostic factors and long-term outcome after surgery.
Brain & spineSkull Base Collision Tumors: Giant Non-functioning Pituitary Adenoma and Olfactory Groove Meningioma.
CureusResults of surgical therapy of functioning pituitary adenomas.
Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, CzechoslovakiaNon-functioning pituitary macroadenoma following surgery: long-term outcomes and development of an optimal follow-up strategy.
Frontiers in surgeryExploring endocrinological pitfalls in pituitary surgery in the elderly.
HeliyonPituitary metastasis of hepatocellular carcinoma as the initial presentations: a case report and review of the literature.
Frontiers in oncologyPituitary function at presentation and following therapy in patients with non-functional pituitary macroadenomas: a single centre retrospective cohort study.
EndocrineNatural history of non-functioning pituitary microadenomas: results from the UK non-functioning pituitary adenoma consortium.
European journal of endocrinologyPost-Operative Medium- and Long-Term Endocrine Outcomes in Patients with Non-Functioning Pituitary Adenomas-Machine Learning Analysis.
CancersExpression of LINC00174 in different cancers: Review of the literature and bioinformatics analyses.
Pathology, research and practiceNatural history of pituitary apoplexy: a long-term follow-up study.
Postgraduate medical journalDysregulation of PVT1 and NEAT1 lncRNAs in pituitary adenomas.
Pathology, research and practiceSleep quality in patients with non-functioning pituitary adenoma: impact of replacement therapies with an emphasis on the time of hydrocortisone.
PituitaryHealthcare cost and survival in patients with non-functioning pituitary adenoma.
European journal of endocrinologyUpregulation of MAPKAPK5-AS1, PXN-AS1 and URB1-AS1 lncRNAs in non-functioning pituitary adenoma.
Journal of cellular and molecular medicinePsychiatric disorders and anger in patients with controlled acromegaly.
Minerva endocrinologyLow Bone Density and High Sclerostin in Non-Functioning Pituitary Adenoma.
Journal of clinical densitometry : the official journal of the International Society for Clinical DensitometryEvaluation of preoperative visual pathway impairment in patients with non-functioning pituitary adenoma using diffusion tensor imaging coupled with optical coherence tomography.
Frontiers in neuroscienceCollision of Two Tumors: A Case Report of a Lung Adenocarcinoma With Metastasis to a Pituitary Adenoma.
Journal of the ASEAN Federation of Endocrine SocietiesRisk Factors, Radiological and Clinical Outcomes in Subclinical and Clinical Pituitary Apoplexy.
Journal of clinical medicineChanges in Sinonasal and Overall Quality of Life Following Endoscopic Endonasal Surgery for Non-functioning Pituitary Adenomas: Results of A Prospective Observational Study.
Neurology IndiaSleep patterns in patients treated for non-secreting intra- and parasellar tumors: A self-report case-control study.
Frontiers in endocrinologyPost-operative surveillance for somatotroph, lactotroph and non-functional pituitary adenomas after curative resection: a systematic review.
PituitaryEffect of cabergoline on tumor remnant after surgery in nonfunctioning pituitary adenoma.
Journal of neuro-oncologyEpigenomic and transcriptomic landscaping unraveled candidate repositioned therapeutics for non-functioning pituitary neuroendocrine tumors.
Journal of endocrinological investigationImpact of histopathological classification of non-functioning adenomas on long term outcomes: comparison of the 2004 and 2017 WHO classifications.
PituitaryCorrelation between tumor volume and serum prolactin and its effect on surgical outcomes in a cohort of 219 prolactinoma patients.
Journal of neurosurgeryManagement after initial surgery of nonfunctioning pituitary adenoma: surveillance, radiotherapy or surgery?
Radiation oncology (London, England)DNA Methylation Profiling in Rare Sellar Tumors.
BiomedicinesA Factorial Analysis on Visual Outcomes of Transsphenoidal Surgery for Pituitary Macroadenoma.
Asian journal of neurosurgeryExpression pattern of non-coding RNAs in non-functioning pituitary adenoma.
Frontiers in oncologyEndoscopic transsphenoidal surgery for non-functioning pituitary adenoma: Learning curve and surgical results in a prospective series during initial experience.
Frontiers in surgeryTreatment of non-functioning pituitary adenoma with cabergoline: a systematic review and meta-analysis.
PituitaryA systematic review of molecular alterations in invasive non-functioning pituitary adenoma.
EndocrineSevoflurane anesthesia rather than propofol anesthesia is associated with 3-month postoperative hypocortisolism in patients undergoing endoscopic transsphenoidal surgery for non-functional pituitary adenoma with preoperative normal hypothalamic-pituitary-adrenal axis.
Acta neurochirurgicaAssociation between overweight and growth hormone secretion in patients with non-functioning pituitary tumors.
PloS oneDiscrimination between non-functioning pituitary adenomas and hypophysitis using machine learning methods based on magnetic resonance imaging‑derived texture features.
PituitaryEctopic Cushing's syndrome from an ACTH-producing pheochromocytoma with a non-functioning pituitary adenoma.
Endocrinology, diabetes & metabolism case reportsMultivariable Diagnostic Prediction Model to Detect Hormone Secretion Profile From T2W MRI Radiomics with Artificial Neural Networks in Pituitary Adenomas.
Medeniyet medical journalLate onset of pituitary apoplexy following gonadotropin-releasing hormone agonist for prostate cancer treatment.
BMJ case reportsDeterminants of Short-Term Weight Gain Following Surgical Treatment for Craniopharyngioma in Adults.
Journal of Korean Neurosurgical SocietyRole of microRNAs in non-functioning pituitary adenoma.
JPMA. The Journal of the Pakistan Medical AssociationMetachronous Double Pituitary Adenoma with Altered Transcriptional Factor Profile: A Case Report and Literature Review.
NMC case report journalHemostasis through Extended Transsphenoidal Route for Subarachnoid Hemorrhage after Conventional Transsphenoidal Surgery for a Pituitary Adenoma.
NMC case report journalGamma knife radiosurgery in pituitary adenomas. A single-center experience.
MedicinaA rare case of macroprolactinoma in a patient with Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome.
Endocrinology, diabetes & metabolism case reportsAn Update on Silent Corticotroph Adenomas: Diagnosis, Mechanisms, Clinical Features, and Management.
CancersA Novel Three-LncRNA Signature Predicting Tumor Recurrence in Nonfunctioning Pituitary Adenomas.
Frontiers in geneticsPseudocapsular resection in elderly patients with non-functioning pituitary adenoma.
Clinical neurology and neurosurgeryDeep learning-based thin-section MRI reconstruction improves tumour detection and delineation in pre- and post-treatment pituitary adenoma.
Scientific reportsMachine-Learning Prediction of Postoperative Pituitary Hormonal Outcomes in Nonfunctioning Pituitary Adenomas: A Multicenter Study.
Frontiers in endocrinologyBaseline MRI findings as predictors of hypopituitarism in patients with non-functioning pituitary adenomas.
Endocrine connectionsCardiovascular risk profile in growth hormone-treated adults with craniopharyngioma compared to non-functioning pituitary adenoma: a national cohort study.
European journal of endocrinologyIsolated Neuropsychiatric Features with Non-functioning Pituitary Adenoma: Association or Coincidence?
Journal of pediatric neurosciencesPseudo-Cushing's state in a patient with non-functioning pituitary adenoma.
BMJ case reportsStereotactic Radiosurgery and Hypofractionated Stereotactic Radiotherapy for Nonfunctioning Pituitary Adenoma.
Journal of neurological surgery. Part B, Skull baseSafety of growth hormone (GH) treatment in GH deficient children and adults treated for cancer and non-malignant intracranial tumors-a review of research and clinical practice.
PituitaryPredictive factors of postoperative diabetes insipidus in 333 patients undergoing transsphenoidal surgery for non-functioning pituitary adenoma.
PituitaryThe open sella technique for surgical treatment of pituitary macroadenomas: Safety and efficacy in a large clinical series.
British journal of neurosurgeryGiant Recurrence Pituitary Adenoma After Three Times Transphenoidal Removal Surgery, One Craniotomy Procedure, and 30 Doses of External Radiotherapy.
Acta medica IndonesianaSphenoid sinus mucosal thickening in patients with non-functioning pituitary adenoma.
International journal of clinical practicePituitary Hormonal Status after Endoscopic Endonasal Transphenoidal Removal of Nonfunctioning Pituitary Adenoma: 5 years' Experience in a Single Center.
Asian journal of neurosurgeryPituitary disease and pregnancy.
Endocrinologia, diabetes y nutricionSafety of Endoscopic Transsphenoidal Pituitary Surgery during the COVID-19 Pandemic and Comparison to the Pre-Pandemic Era.
Journal of neurological surgery. Part B, Skull baseNon-functioning pituitary adenomas and pregnancy: one-center experience and review of the literature.
Archives of endocrinology and metabolismUp-To-Date Magnetic Resonance Imaging Findings for the Diagnosis of Hypothalamic and Pituitary Tumors.
Yonago acta medicaEarly hormonal recovery following endoscopic transsphenoidal surgery for silent non-functioning pituitary adenomas with hormone dysfunction.
Journal of neuro-oncologyScreening and Identification of Key Microenvironment-Related Genes in Non-functioning Pituitary Adenoma.
Frontiers in geneticsRapid resolution of a third nerve palsy from pituitary apoplexy.
BMJ case reportsThe outcome of TSHoma from a tertiary care institute in India.
Surgical neurology internationalQuality of Life and Sleep in Patients with Pituitary Adenoma in Relation to Tumor Type and Compression of the Optic Chiasm.
Journal of clinical medicineRole of pituitary stalk and gland radiological status on endocrine function and outcome after endoscopic transsphenoidal surgery for non-functioning pituitary adenomas.
EndocrineGH-induced LH hyporesponsiveness as a potential mechanism for hypogonadism in male patients with acromegaly.
Endocrine journalA comparative study of functioning and non-functioning pituitary adenomas.
MedicineNomogram predictive model of post-operative recurrence in non-functioning pituitary adenoma.
Gland surgeryOutcome Squares Integrating Efficacy and Safety, as Applied to Functioning Pituitary Adenoma Surgery.
The Journal of clinical endocrinology and metabolismIdentifying critical protein-coding genes and long non-coding RNAs in non-functioning pituitary adenoma recurrence.
Oncology lettersClinical Parameters of Silent Corticotroph Adenomas With Positive and Negative Adrenocorticotropic Hormone Immunostaining: A Large Retrospective Single-Center Study of 105 Cases.
Frontiers in endocrinologyPractice patterns in the management of recurrent and residual non-functioning pituitary adenomas: Results from a Canada-wide survey.
eNeurologicalSciDome-Shaped Pituitary Enlargement in Primary Hypothyroidism: Avoiding Neurosurgical Interventions.
Journal of the ASEAN Federation of Endocrine SocietiesIdentification of a TMEM127 variant in a patient with paraganglioma and acromegaly.
Endocrinology, diabetes & metabolism case reportsESE audit on management of Adult Growth Hormone Deficiency in clinical practice.
European journal of endocrinologyPseudoacromegaly Associated with Non-Functioning Pituitary Adenoma.
European journal of case reports in internal medicineChromosomal and oxidative DNA damage in non-functioning pituitary adenomas.
Endokrynologia PolskaCephalocaudal tumor diameter is a predictor of diabetes insipidus after endoscopic transsphenoidal surgery for non-functioning pituitary adenoma.
PituitaryChiasmapexy for secondary empty sella syndrome: diagnostic and therapeutic considerations.
PituitaryCharacteristics and clinical outcomes in pituitary incidentalomas and non-incidental pituitary tumors treated with endoscopic transsphenoidal surgery.
MedicineIncidence, mortality, and cardiovascular diseases in pituitary adenoma in Korea: a nationwide population-based study.
PituitaryMRI radiomics for the prediction of recurrence in patients with clinically non-functioning pituitary macroadenomas.
Computers in biology and medicineThe GALANT trial: study protocol of a randomised placebo-controlled trial in patients with a 68Ga -DOTATATE PET-positive, clinically non-functioning pituitary macroadenoma on the effect of lan reotide on t umour size.
BMJ openFull Remission of Long-Term Premenstrual Dysphoric Disorder-Like Symptoms Following Resection of a Pituitary Adenoma: Case Report.
The American journal of case reportsThe quality of life after transnasal microsurgical and endoscopic resection of nonfunctioning pituitary adenoma.
Advances in clinical and experimental medicine : official organ Wroclaw Medical UniversityHealth-related quality of life in patients with non-functioning pituitary adenoma: a special focus on hydrocortisone replacement dose.
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitationCell proliferation, apoptosis, and angiogenesis in non-functional pituitary adenoma: association with tumor invasiveness.
EndocrineAssociation of PTP4A3 expression and tumour size in functioning pituitary adenoma: a descriptive study.
Journal of clinical pathologyCurrent Status of Diagnosis and Management for Functioning Pituitary Tumors: Part I.
Neurology IndiaIdentification of a multidimensional transcriptome signature predicting tumor regrowth of clinically non‑functioning pituitary adenoma.
International journal of oncologyQuality of care evaluation in non-functioning pituitary adenoma with chiasm compression: visual outcomes and timing of intervention clinical recommendations based on a systematic literature review and cohort study.
PituitaryNON-FUNCTIONAL PITUITARY TUMORS: A MISLEADING PRESENTATION OF AN INTRASELLAR PLASMACYTOMA.
Acta endocrinologica (Bucharest, Romania : 2005)The coexistence of recurrent pituitary adenoma and meningioma: case report.
Translational cancer researchComparative analysis of rhinologic outcomes in Cushing disease and non-functioning pituitary adenoma in patients submitted to endoscopic endonasal transsphenoidal surgery.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck SurgeryContent and system development of a digital patient-provider communication tool to support shared decision making in chronic health care: InvolveMe.
BMC medical informatics and decision making68Ga-DOTATATE PET imaging in clinically non-functioning pituitary macroadenomas.
European journal of hybrid imagingIntegrated analysis of DNA methylation and mRNA expression profiles to identify key genes involved in the regrowth of clinically non-functioning pituitary adenoma.
AgingCut-off values for sufficient cortisol response to low dose Short Synacthen Test after surgery for non-functioning pituitary adenoma.
Acta neurochirurgicaGiant Non-Functioning Pituitary Adenoma: Clinical Characteristics and Therapeutic Outcomes.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes AssociationIdentification of key genes in invasive clinically non-functioning pituitary adenoma by integrating analysis of DNA methylation and mRNA expression profiles.
Journal of translational medicinePreoperative growth hormone (GH) peak values during a GH releasing peptide-2 test reflect the severity of hypopituitarism and the postoperative recovery of GH secretion in patients with non-functioning pituitary adenomas.
Endocrine journalAn aggressive functioning pituitary adenoma treated with peptide receptor radionuclide therapy.
European journal of nuclear medicine and molecular imagingMultimodal therapy in aggressive pituitary tumors.
Endocrinologia, diabetes y nutricionPostoperative expression of Cushing disease in a young male: metamorphosis of silent corticotroph adenoma?
Endocrinology, diabetes & metabolism case reportsT5224, RSPO2 and AZD5363 are novel drugs against functional pituitary adenoma.
AgingIdentification of CDK6 and RHOU in Serum Exosome as Biomarkers for the Invasiveness of Non-functioning Pituitary Adenoma.
Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chihFunctioning Pituitary Adenoma with Xanthogranulomatous Features: Review of Literature and Case Report.
Journal of neurological surgery. Part B, Skull baseCavernous sinus haemangioma with intrasellar extension mimicking non-functioning pituitary adenoma - A case report and review of literature.
Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation OncologyThe burden of disease for pituitary patients.
Best practice & research. Clinical endocrinology & metabolismThe benefit and risk of stereotactic radiosurgery for prolactinomas: an international multicenter cohort study.
Journal of neurosurgerySignificance of Elevated HMGB1 Expression in Pituitary Apoplexy.
Anticancer researchEndocrinological Outcome of Endoscopic Transsphenoidal Surgery for Functioning and Non-Functioning Pituitary Adenoma.
The Malaysian journal of medical sciences : MJMSUnexpected concomitant pituitary adenoma and suprasellar meningioma: a case report and review of the literature.
British journal of neurosurgeryThe pre- and postoperative illness trajectory in patients with pituitary tumours.
Endocrine connectionsPredicting the regrowth of clinically non-functioning pituitary adenoma with a statistical model.
Journal of translational medicineNon-functioning pituitary macroadenoma: surgical outcomes, tumor regrowth, and alterations in pituitary function-3-year experience from the Iranian Pituitary Tumor Registry.
Hormones (Athens, Greece)Identification of Important Invasion-Related Genes in Non-functional Pituitary Adenomas.
Journal of molecular neuroscience : MNQuality of Life but not Cognition is Impacted by Radiotherapy in Patients with Non-Functioning Pituitary Adenoma.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolismePre-operative MRI predictors of hormonal remission status post pituitary adenoma resection.
Clinical imagingEndocrinological Outcomes of Intraoperative MRI-Guided Endoscopic Transsphenoidal Surgery for Non-Functioning Pituitary Adenoma.
Turkish neurosurgeryIncidence rate and risk factors of early repolarization in patients with growth hormone-secreting pituitary adenoma: a cohort study.
Therapeutics and clinical risk managementAssociation of PTTG1 polymorphism rs1895320, rs2910200 and rs6882742 with non-functioning pituitary adenomas in Chinese Han population: a case-control study.
Metabolic brain diseaseRecurrence in silent corticotroph adenomas after primary treatment: A systematic review and meta-analysis.
The Journal of clinical endocrinology and metabolismA two‑circRNA signature predicts tumour recurrence in clinical non‑functioning pituitary adenoma.
Oncology reportsGenome-wide identification of lncRNAs and mRNAs differentially expressed in non-functioning pituitary adenoma and construction of an lncRNA-mRNA co-expression network.
Biology openSpindle cell oncocytoma of the neurohypophysis with metastasis to the sphenoparietal sinus and immunohistochemical negativity for S100 and epithelial membrane antigen (EMA).
British journal of neurosurgeryAutoimmune thyroid diseases are more common in patients with prolactinomas: a retrospective case-control study in an Italian cohort.
Journal of endocrinological investigationComorbidities in patients with non-functioning pituitary adenoma: influence of long-term growth hormone replacement.
European journal of endocrinologyFGFR2 gene polymorphism rs2981582 is associated with non-functioning pituitary adenomas in Chinese Han population: a case-control study.
Bioscience reportsSpectrum of Pituitary disorders: A retrospective study from Basrah, Iraq.
F1000ResearchAssociações
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- The clinical value of [18F]-fluoro-ethyl-L-tyrosine PET ([18F]FET-PET) correlated with MRI in patients with functioning pituitary adenomas: an observational cohort study.
- Oridonin regulates pituitary-derived folliculostellate cells apoptosis via the p38 MAPK/p53 signalling pathway.
- Sex-related differences in healthcare utilization and costs among patients with pituitary adenomas.
- Decoy Lesion in Functional Multiple Pituitary Adenomas: Literature Review and Illustrative Cases on Diagnostic Pitfalls and Surgical Strategies.
- Cavernous Sinus Medial Wall Resection: A Retrospective Single-Institution Study on Outcomes in Functional Pituitary Adenomas.
- Hypogonadotropic Hypogonadism Before and After Transsphenoidal Surgery for Non-Functioning Pituitary Adenoma.
- The impact of a non-functioning pituitary adenoma on life - A qualitative study of patients' experiences.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:314753(Orphanet)
- MONDO:0003429(MONDO)
- GARD:21389(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Q18556775(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
