Doença veno-oclusiva hepática

Defibrotide Dose-escalation for SOS Post-HSCT

NCT05987124

RECRUTANDO

Clinical Diagnosis and Pathological Spectrum of Porto-sinusoidal Vascular Disease in India

NCT06054451

RECRUTANDO

Using Ultrasound Elastography to Predict Development of Hepatic Sinusoidal Obstruction Syndrome

NCT03865589

EM ANDAMENTO

Ultrasound Elastography to Predict Development of SOS

NCT03858530

DESCONHECIDO

Liver Stiffness Measurement Predicts VOD/SOS Development (ELASTOVOD ITALIAN MULTICENTRIC STUDY)

NCT03426358

CONCLUÍDO

🟢 Recrutando agora

2 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

NCT05987124 · Defibrotide Dose-escalation for SOS Post-HSCTRecrutando

PHASE2

NCT06054451 · Clinical Diagnosis and Pathological Spectrum of Porto-sinuso…Recrutando

Outros ensaios clínicos

25 ensaios clínicos encontrados, 3 ativos.

Distribuição por fase

NCT03865589 · Using Ultrasound Elastography to Predict Development of Hepa…Ativo

NCT03858530 · Ultrasound Elastography to Predict Development of SOSEncerrado

NCT03426358 · Liver Stiffness Measurement Predicts VOD/SOS Development (EL…Concluído

NCT02851407 · Study Comparing Efficacy and Safety of Defibrotide vs Best S…Concluído

PHASE3

NCT04313036 · 5-day Defibrotide Treatment for Hepatic SOS/VODUNKNOWN

PHASE2

NCT01886248 · Antithrombin-III for Patients With Hepatic Veno-occlusive Di…UNKNOWN

PHASE2

NCT03963999 · Validating Ultrasound Biomarkers for Hepatic Sinusoidal Obst…Cancelado

PHASE4

NCT04168788 · Pharmacogenetic Study of Antimitotic Therapies Involved in H…UNKNOWN

NCT03032016 · European VOD RegistryConcluído

NCT00628498 · Defibrotide for Patients With Hepatic Veno-occlusive Disease…Concluído

PHASE3

NCT00143546 · Compassionate Use of Defibrotide for Patients With Veno-occl…NO_LONGER_AVAILABLE

NCT00358501 · Defibrotide for the Treatment of Severe Hepatic Veno-Occlusi…Concluído

PHASE3

NCT00272948 · Pediatric Trial Investigating the Incidence & Outcome of Ven…Concluído

PHASE2, PHASE3

NCT00563498 · Effects on Glutamine on the Outcome of Allogeneic Bone Marro…UNKNOWN

Ver todos no ClinicalTrials.gov

🧪 Está conduzindo uma pesquisa?

Divulgue para pacientes e familiares que acompanham esta doença.

Divulgar pesquisa →

Publicações mais relevantes

🥇Melhor nível de evidência: Meta-análise

Timeline de publicações

229 papers (10 anos)

#1

Transjugular intrahepatic portosystemic shunt improves survival in anticoagulation-resistant hepatic sinusoidal obstructive syndrome patients: A multicenter retrospective study.

World journal of hepatology2026 Feb 27

Anticoagulation therapy is recommended during the acute or subacute stage for patients with pyrrolizidine alkaloid-hepatic sinusoidal obstruction syndrome (PA-HSOS). Transjugular intrahepatic portosystemic shunts (TIPS) is suggested as a step-up treatment when patients do not respond to anticoagulants. However, more evidence of the efficacy of TIPS is needed. To evaluate the effect of TIPS in these patients. Between January 2013 and September 2020, we retrospectively enrolled patients with PA-HSOS who did not respond to short-term anticoagulation therapy at four hospitals. The patients were divided into a TIPS treatment group and an anticoagulation therapy group. Baseline information and clinical characteristics were collected and recorded. Survival in both groups was the primary study endpoint and the risk factors for patient death were further analyzed. A total of 99 patients were enrolled according to the inclusion and exclusion criteria (63 in the TIPS group and 36 in the anticoagulation therapy group). There were 17 deaths during the median follow-up time of 32.5 months. Treatment, age, aspartate aminotransferase, and serum total bilirubin were independent risk factors for predicting death. The survival of patients in the TIPS group was significantly greater than that of patients in the continuing anticoagulation therapy group (P = 0.028). When stratified by the Drum-Tower Severity Scoring, in the TIPS group, mild and moderate patients had better outcomes than severe patients. TIPS can improve the transplant-free survival rate in patients with PA-HSOS who do not respond to short-term anticoagulation therapy, and patients with mild and moderate Drum-Tower Severity Scoring grade can benefit from TIPS.

#2

Epidemiology and Outcomes of Hepatic Veno-Occlusive Disease after Allogeneic Hematopoietic Stem Cell Transplantation: A Descriptive Analysis of the U.S. National Inpatient Sample.

Hematology/oncology and stem cell therapy2026 Feb 02

Hepatic veno-occlusive disease (HVOD), or sinusoidal obstruction syndrome (SOS), is a potentially liefe-threatening complication following allogeneic stem cell transplantation (allo-SCT). Historically, HVOD has affected up to 60% of allo-SCT recipients, with reported mortality rates exceeding 75% in severe cases. The approval of defibrotide in 2016 represented a major therapeutic milestone, significantly improving outcomes in high-risk patients. Despite this advancement, large-scale data on HVOD epidemiology & outcomes in allo-SCT recipients remain limited. This study aims to address these gaps & offer updated insights into its clinical impact. We utilized National Inpatient Sample (2016-2020) to examine factors associated with HVOD in allo-SCT recipients. Admissions for allo-SCT & HVOD were identified using International Classification of Diseases, Tenth Revision. Baseline characteristics, including patient demographics, hospital characteristics, comorbidities, complications & outcomes were compared between allo-SCT admissions with & without HVOD. Categorical variables were analyzed by χ² test (%), & continuous variables by adjusted Wald's test (mean±SD). During the study period, 200 allo-SCT admissions with HVOD were identified. HVOD admissions were younger (45.05 vs. 52.42 years; P=0.0045) & were more likely to be female (43.72% vs. 25%; P=0.0191). They had higher rates of acute graft-versus-host disease (GVHD) (17.5% vs. 6.47%; P=0.0043), acute respiratory failure (32.5% vs. 8.37%; P<0.001), & acute kidney injury (50% vs. 20.66%; P<0.001). Hepatic complications, including portal hypertension (7.5% vs. 0.52%; P<0.001), hepatic encephalopathy (12.5% vs. 0.28%; P<0.001), cirrhosis (7.5% vs. 0.07%; P<0.001), ascites (37.5% vs. 1.97%; P<0.001) & spontaneous bacterial peritonitis (2.5% vs. 0.06%; P<0.001) were also more common in this cohort. HVOD was associated with worse outcomes, including longer hospital stays (45.5 vs. 29.51 days; P<0.001) & over 6 times higher in-hospital mortality (30% vs. 4.72%; P<0.001). HVOD also imposed a greater economic burden, with more than double mean total hospitalization charges ($1,321,650 vs. $541,391.1; P<0.001) & nearly triple hospitalization costs ($358,463.2 vs. $141,464.1; P<0.001). This study describes HVOD-specific characteristics in allo-SCT admissions. Patients with HVOD were younger, had higher comorbidity burden, & showed increased rates of acute GVHD, multiorgan dysfunction, & hepatic complications. They also faced high in-hospital mortality, longer hospital stays, & greater healthcare costs.

#3

Two Cases of Hepatic Epithelioid Hemangioendothelioma Misdiagnosed With Hepatic Veno-Occlusive Disease.

Case reports in hepatology2026

Hepatic epithelioid hemangioendothelioma (HEHE) is a rare tumor of vascular origin with an incidence of < 0.1/100,000. The disease is easily misdiagnosed. The aim of this article is to increase public awareness and vigilance of HEHE. We report two cases presenting with fever, abdominal discomfort, abnormal liver function, and jaundice. Computed tomography (CT) and magnetic resonance imaging (MRI) of the abdomen suggested hepatic stasis, venous compression, and ascites, and liver biopsy was initially misdiagnosed as hepatic veno-occlusive disease (VOD), which did not improve with treatment. In the first case, a male patient, after liver transplantation, pathological and immunohistochemical (IHC) analyses revealed hyperplasia of blood vessels in the liver tissue with dilated lumen and heterogeneous cells. Immunohistochemistry was performed and showed CD34 positivity, confirming the diagnosis of HEHE. The second female patient had liver bruising and ascites on imaging, and the first hepatic puncture was reported to be VOD, which did not improve with treatment. Repeat hepatic puncture was performed, and the diagnosis of HEHE was confirmed after a second repathology with additional immunohistochemistry for HEHE. These misdiagnosis cases highlight the challenge of diagnosing HEHE. This is the first report of misdiagnosis of HEHE as VOD. This article analyzes the underlying causes of misdiagnosis of HEHE and emphasizes the causes of imaging misdiagnosis and the importance of repeated hepatic puncture biopsy and immunohistochemistry in the diagnosis of HEHE.

#4

Real-World Outcome of Defibrotide Treatment for Severe Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome after Hematopoietic Cell Transplantation.

Transplantation and cellular therapy2026 Feb

Hepatic veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a serious complication following hematopoietic cell transplantation (HCT), with a markedly poor prognosis in patients with severe or very severe presentations. Defibrotide (DF) is the sole approved treatment for severe to very severe VOD/SOS, but real-world evidence remains limited, particularly in East Asian populations. We retrospectively analyzed 73 adult patients with severe or very severe VOD/SOS treated with DF between 2016 and 2023 at a single tertiary center in Korea. Diagnosis and grading were based on the revised European Society for Blood and Marrow Transplantation criteria. During the study period, national reimbursement guidelines for DF evolved from requiring ≥4 of 6 severity criteria to ≥2 of 5 severity criteria, allowing earlier initiation of treatment. The median time from HCT to diagnosis of VOD/SOS was 24 days (range, 1 to 843 days), and DF was administered within a median of 1 day after diagnosis. At DF initiation, 40 patients were classified as severe and 33 were classified as very severe; disease progression resulted in 53 patients reaching the very severe category. The overall response rate was 46.5%, and complete resolution was achieved in 39.7% of cases. The 100-day overall survival was 34.2%, significantly higher in the patients receiving DF within 2 days of diagnosis (36.0% versus 17.4%; P = .049). High total bilirubin levels at diagnosis and at the worst disease period were strongly associated with poor long-term survival regardless of severity criteria. These data provide real-world support for the early use of DF and suggest the prognostic utility of total bilirubin level in guiding treatment for VOD/SOS following HCT.

#5

Impact of Oral Eicosapentaenoic Acid on Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome Onset Prevention: Single-Center Retrospective Analysis.

Transplantation and cellular therapy2026 Mar

Veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a serious complication associated with allogeneic hematopoietic stem cell transplantation (allo-HSCT). Although ursodeoxycholic acid and defibrotide can reduce the risk of VOD/SOS, preventive efforts remain insufficient. In 2009, we began prescribing oral eicosapentaenoic acid (EPA) to mitigate post-transplant complications. Notably, no patients receiving EPA developed VOD/SOS. In this retrospective study, we analyzed 138 transplants from 123 patients who underwent allo-HSCT at Ehime University Hospital between April 2008 and June 2024. Ninety-one patients received EPA after allo-HSCT (EPA group), while 47 patients did not (no-EPA group). EPA was administered at a dose of 1800 mg/d, divided into 2 or 3 doses. All patients were taking ursodeoxycholic acid. VOD/SOS occurred in 3 patients in the no-EPA group (6.5%) and in none of the EPA group (P = 0.014). Early post-transplant mortality within 100 d did not differ significantly between groups. Although causal inference is limited by the retrospective design of the study, our findings suggest that EPA use may be associated with a lower incidence of VOD/SOS. These findings warrant prospective, multicenter trials to determine whether EPA can improve transplant outcomes by reducing the incidence of VOD/SOS.

Publicações recentes

[Clinical Analysis of Allogeneic Hematopoietic Stem Cell Transplantation for Very Early-Onset Inflammatory Bowel Disease Caused by IL-10RA Mutation].

Zhongguo Shi Yan Xue Ye Xue Za Zhi2026 Feb

Transjugular intrahepatic portosystemic shunt improves survival in anticoagulation-resistant hepatic sinusoidal obstructive syndrome patients: A multicenter retrospective study.

🥇 Meta-análise

World J Hepatol2026 Feb 27

Epidemiology and Outcomes of Hepatic Veno-Occlusive Disease after Allogeneic Hematopoietic Stem Cell Transplantation: A Descriptive Analysis of the U.S. National Inpatient Sample.

Hematol Oncol Stem Cell Ther2025 Oct-Dec 01

Two Cases of Hepatic Epithelioid Hemangioendothelioma Misdiagnosed With Hepatic Veno-Occlusive Disease.

Case Reports Hepatol2026

Proteomic Signatures and Early Biomarkers Predicting Veno-Occlusive Disease in Pediatric Patients Undergoing Haploidentical Hematopoietic Cell Transplantation with Busulfan-Based Conditioning and Post-Transplant Cyclophosphamide.

Transplant Cell Ther2025 Dec 22

Ver todas no PubMed

📚 EuropePMC361 artigos no totalmostrando 198

Zhongguo shi yan xue ye xue za zhi

[Clinical Analysis of Allogeneic Hematopoietic Stem Cell Transplantation for Very Early-Onset Inflammatory Bowel Disease Caused by IL-10RA Mutation].

World journal of hepatology

Transjugular intrahepatic portosystemic shunt improves survival in anticoagulation-resistant hepatic sinusoidal obstructive syndrome patients: A multicenter retrospective study.

Molecules (Basel, Switzerland)

Hepatic Sinusoidal Obstruction Syndrome Induced by Pyrrolizidine Alkaloids from Gynura segetum: Mechanisms and Therapeutic Advances.

Journal of ethnopharmacology

Gancao decoction ameliorated senecionine-induced Hepatic Sinusoidal Obstruction Syndrome in mice by inhibiting NET formation and senecionine bioactivation in liver.

Hematology/oncology and stem cell therapy

Epidemiology and Outcomes of Hepatic Veno-Occlusive Disease after Allogeneic Hematopoietic Stem Cell Transplantation: A Descriptive Analysis of the U.S. National Inpatient Sample.

Case reports in hepatology

Two Cases of Hepatic Epithelioid Hemangioendothelioma Misdiagnosed With Hepatic Veno-Occlusive Disease.

Chronic portal hypertension following inotuzumab ozogamicin in a low-risk patient: a case of overriding baseline risk and long-term management.

Annals of hematology

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

[Research progress on animal models relevant to porto-sinusoidal vascular disease].

Proteomic Signatures and Early Biomarkers Predicting Veno-Occlusive Disease in Pediatric Patients Undergoing Haploidentical Hematopoietic Cell Transplantation with Busulfan-Based Conditioning and Post-Transplant Cyclophosphamide.

Therapeutic advances in hematology

Real-world treatment outcome and toxicity analysis of inotuzumab ozogamicin in adult patients with relapsed or refractory B-cell precursor acute lymphoblastic leukemia: multicenter prospective observational study.

Pharmacogenetics and genomics

Effects of glutathione- S -transferase polymorphisms on intravenous busulfan in hematopoietic stem cell transplant patients: a meta-analysis.

Transjugular intrahepatic portosystemic shunt for hepatic sinusoidal obstruction syndrome with primary biliary cholangitis and alcoholic liver disease: a case report.

Frontiers in medicine

[Rinsho ketsueki] The Japanese journal of clinical hematology

[Inotuzumab ozogamicin-associated sinusoidal obstruction syndrome/veno-occlusive disease diagnosed by transjugular liver biopsy].

Modeling antithymocyte globulin-induced microvasculopathy using human iPSC-derived vascularized liver organoids.

Cell reports. Medicine

Non-caucasian ethnicity as a risk factor for sinusoidal obstruction syndrome/hepatic veno-occlusive disease following haematopoietic stem cell transplantation.

Anales de pediatria

PLoS neglected tropical diseases

Community perceptions and practices on hepatic veno-occlusive disease in Tigray, Ethiopia: An explorative study challenging the attribution to Ageratum conyzoides.

Real-World Outcome of Defibrotide Treatment for Severe Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome after Hematopoietic Cell Transplantation.

Impact of Oral Eicosapentaenoic Acid on Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome Onset Prevention: Single-Center Retrospective Analysis.

Efficacy of ibrutinib and diagnostic liver biopsy for idiopathic refractory ascites after allogeneic stem cell transplantation.

Clinical lymphoma, myeloma & leukemia

Prognostic Impact of the Level of Minimal Residual Disease Prior to Allogeneic Hematopoietic Stem Cell Transplantation on Pediatric Patients With Acute Lymphoblastic Leukemia: A 10-Year Single-Center Study.

Veno-Occlusive Disease in Very Young Children: A Profile of High Morbidity With Low Mortality.

Multiple Hematopoietic Stem Cell Transplantations in Pediatric Acute Myeloid Leukemia: Prognostic Significance of Remission and Severe Sinusoidal Obstruction Syndrome.

Transient and Shear-Wave Elastography in the Detection of Hepatic Sinusoidal Obstruction Syndrome in Patients Undergoing Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis.

Clinical and experimental hepatology

Serum ascites albumin gradient in predicting the severity of hepatic sinusoidal obstruction syndrome induced by pyrrolizidine alkaloids.

Efficacy and safety of transjugular intrahepatic portosystemic shunt in hepatic sinusoidal obstruction syndrome: systematic review and meta-analysis.

Frontiers in medicine

Syndecan-1 is Associated With Sinusoidal Obstruction Syndrome and Severe Acute Graft-Versus-Host Disease After Pediatric Hematopoietic Stem Cell Transplantation.

Annali italiani di chirurgia

Albumin-Bilirubin and Severity as Key Factors of Recovery in Patients With PA-HSOS Undergoing Transjugular Intrahepatic Portosystemic Shunt.

Clinical journal of gastroenterology

Antibody-mediated rejection without elevated anti-blood type antibody after ABO-incompatible living donor liver transplantation: a case report.

International journal of molecular sciences

Genetic Susceptibility in Sinusoidal Obstruction Syndrome/Veno-Occlusive Disease: A Case-Control Study.

Defibrotide for Protecting Against and Managing Endothelial Injury in Hematologic Malignancies and COVID-19.

Biomolecules

BMC pharmacology & toxicology

Drug-induced sinusoidal obstruction syndrome: a real-world pharmacovigilance study based on the FDA Adverse Event Reporting System (FEARS).

Vascular Liver Disease: Emerging Concepts in the Sinusoidal Space.

Hepatotoxicity of Chemotherapy and Immune Checkpoint Inhibitors.

The Liver in Hematologic Malignancies: Lymphoma, Leukemia, and Myeloma.

Results of a Phase II Trial for Intermediate-Risk Rhabdomyosarcoma Treatment Protocol JRS-I: A Report From the Japan Rhabdomyosarcoma Study Group.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

Unveiling the clinical spectrum of Porto-Sinusoidal Vascular Disorder (PSVD) with chronic HBV infection: insights from a retrospective Chinese cohort.

Histology and histopathology

PU.1 aggravates hepatic sinusoidal obstruction syndrome by upregulating PTBP1 and activating the Wnt/β-catenin pathway.

Utility of tolvaptan sodium phosphate for refractory fluid retention in post-transplant sinusoidal obstruction syndrome.

Platelet aggregation elicits FasL expression and hepatocyte apoptosis in sinusoidal obstruction syndrome.

Scientific reports

Sinusoidal Obstruction Syndrome After Allogeneic Hematopoietic Cell Transplantation With Post-Transplant Cyclophosphamide.

American journal of hematology

Classical and Late-Onset SOS/VOD After Allogeneic HSCT: A Japanese Transplant Registry Analysis.

Journal of digestive diseases

Validation of Drum Tower Severity Scoring (DTSS) System for Pyrrolizidine Alkaloid-Induced Hepatic Sinusoidal Obstruction Syndrome.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

Hepatic sinusoidal congestion associated with inotuzumab therapy in patients with B-cell acute lymphoblastic leukemia, a proposal for a new clinical entity: Calicheamicin syndrome.

Ultrasonographic scoring system for SOS/VOD in pediatric hematopoietic stem cell transplant recipients.

Management of liver sinusoidal obstruction syndrome/veno-occlusive disease in adults: a 2025 perspective from an international expert group.

Atypical features of hepatic veno-occlusive disease/sinusoidal obstruction syndrome after inotuzumab ozogamicin in adult patients with acute lymphoblastic leukemia.

Blood research

Diagnostic accuracy of liver stiffness measurement for the diagnosis of veno-occlusive disease/sinusoidal obstruction syndrome after hematopoietic stem cell transplantation (HSCT), the ELASTOVOD STUDY: an investigator-initiated, prospective, multicentre diagnostic clinical trial.

Cellular and molecular gastroenterology and hepatology

S-Adenosylmethionine Inhibits Plasminogen-Activating Inhibitor-1 and Protects Male Mice From FOLFOX-Induced Liver Injury.

Operational procedure sharing pathway in veno-occlusive disease: a Delphi consensus-based recommendations.

Frontiers in oncology

Soluble Thrombomodulin Is Associated With Endothelial Dysfunction Syndromes After Pediatric Hematopoietic Stem Cell Transplantation.

CIBMTR Registry Data on Inotuzumab Ozogamicin Treatment in Patients with ALL Who Proceeded to Hematopoietic Stem Cell Transplant-A Podcast.

Targeted oncology

Liver international : official journal of the International Association for the Study of the Liver

Inhibition of MALT1 Protease Attenuates Hepatic Sinusoidal Obstruction Syndrome by Modulating NRF2/HO1 and NF-κB Pathway.

Complement activation and vascular complications after pediatric allogeneic hematopoietic stem cell transplantation.

Scientific reports

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery

[A case report of gastric cancer combined with hepatic sinusoidal obstruction syndrome].

Efficacy and safety of currently approved and lower starting doses of inotuzumab ozogamicin in adult patients with relapsed or refractory acute lymphoblastic leukemia: a phase IV study.

Haematologica

Pretransplant Minimal Pleural and Peritoneal Effusion Is a Potential Poor Prognostic Indicator in Allogeneic Hematopoietic Stem Cell Transplantation.

Clinical transplantation

A case of late-onset sinusoidal obstruction syndrome diagnosed histologically before meeting diagnostic criteria.

Drug-induced hepatic sinusoidal obstruction syndrome: current advances and future perspectives.

Archives of toxicology

A Two-Center Study of a Prognostic Model Related to Acute Kidney Injury After Allogeneic Hematopoietic Stem Cell Transplantation in Children: Development of a New Predictive Dynamic Nomogram.

Annals of surgical treatment and research

Perioperative outcomes of sinusoidal obstruction syndrome in patients undergoing liver resection for colorectal metastases after neoadjuvant chemotherapy: a retrospective cohort research.

The EASIX score as a predictor of sinusoidal obstruction syndrome and nonrelapse mortality in paediatric patients receiving allogeneic haematopoietic stem cell transplantation.

Continuous Kidney Replacement Therapy in Children With Sinusoidal Obstruction Syndrome After Hematopoietic Cell Transplant: Outcome and Liberation.

Burden of illness of non-hematopoietic stem cell transplant-related hepatic sinusoidal obstruction syndrome: A systematic review.

Heliyon

Prognostic Factors Associated With Increased Mortality in Pediatric Veno-Occlusive Disease Following Hematopoietic Cell Transplantation.

Clinical transplantation

Journal of inherited metabolic disease

Potential therapeutic uses of L-citrulline beyond genetic urea cycle disorders.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

Porto-sinusoidal vascular disorder with known etiologies had more severe portal hypertension and poorer outcomes.

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

[Rifaximin curative effect and mechanism on monocrotaline-induced hepatic sinusoidal obstruction syndrome in mice].

The benefits of prophylactic defibrotide: Are the tides turning?

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi

[Clinical analysis of allogeneic hematopoietic cell transplantation in 9 patients with hematological malignancies complicated by Gilbert's syndrome].

An international survey to better understand the current incidence, severity, and management of VOD/SOS.

[Rinsho ketsueki] The Japanese journal of clinical hematology

[Sinusoidal obstruction syndrome/veno-occlusive disease: a complication to overcome].

Hepatic sinusoidal obstruction syndrome after immune-checkpoint-inhibitor therapy: when the liver sends SOS.

BMJ case reports

Early defibrotide therapy and risk factors for post-transplant veno-occlusive disease/sinusoidal obstruction syndrome in childhood.

Risk Factors for Sinusoidal Obstruction Syndrome After Hematopoietic Stem Cell Transplantation in Children and Young Adults: A Systematic Review and Meta-Analysis.

Clinical transplantation

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae

[Application Values of New Ultrasound Technologies in the Diagnosis of Hepatic Sinusoidal Obstruction Syndrome].

Biomarker-derived fast-and-frugal decision tree for preemption of veno-occlusive disease/sinusoidal obstructive syndrome.

Blood advances

Pediatric hematology and oncology

Hepatic veno-occlusive disease with asparaginase products: a review of cases reported to the FDA adverse event reporting system and published in the literature.

Refractory Thrombocytopenia is the Earliest Diagnostic Criterion for Sinusoidal Obstruction Syndrome in Children.

International journal of surgical pathology

Intrinsic Causes of Nonfibrotic Portal Hypertension-A Clinicopathologic Review of 56 Patients.

Radiographics : a review publication of the Radiological Society of North America, Inc

Hepatic Sinusoidal Disorders.

Liver elastography for risk-assessment of liver toxicity and risk factors for Sinusoidal obstruction syndrome in patients with acute lymphoblastic leukemia receiving inotuzumab ozogamicin.

Blood cancer journal

Inotuzumab ozogamicin in adult acute lymphoblastic leukemia: Development, current status, and future directions.

Cancer

Internal medicine journal

ANZTCT practice statement: sinusoidal obstruction syndrome/veno-occlusive disease diagnosis and management.

Life (Basel, Switzerland)

Hepatic Veno-Occlusive Disease and Colorectal Cancer: Expect the Unexpected.

JPMA. The Journal of the Pakistan Medical Association

A rare case of Gynura-segetum-related hepatic sinus obstruction syndrome complicated with alcoholic liver disease.

Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru

[Porto sinusoidal vascular disease: an unusual cause of digestive bleeding].

Gut microbiota promotes macrophage M1 polarization in hepatic sinusoidal obstruction syndrome via regulating intestinal barrier function mediated by butyrate.

Gut microbes

Hemostasis and complement in allogeneic hematopoietic stem cell transplantation: clinical significance of two interactive systems.

Verification of the Prediction Accuracy of a Biomarker-Based Prognostic for Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome (VOD/SOS) After Hematopoietic Cell Transplantation (HCT).

Transplantation proceedings

Incidence, Etiology and Prognosis of Initial Liver Injury After Allogeneic Hematopoietic Stem Cell Transplantation: A Multi-Center Retrospective Study.

Porto-sinusoidal Vascular Disease and Portal Hypertension.

Transplantation proceedings

Tacrolimus-Induced Hepatic Vein Occlusive Disease After Deceased Donor Liver Transplantation: A Case Report.

Sinusoidal Obstruction Syndrome/Veno-Occlusive Disease after Unmanipulated Haploidentical Hematopoietic Stem Cell Transplantation with Post-Transplantation Cyclophosphamide: A Study on Behalf of the Spanish Hematopoietic Stem Cell Transplantation and Cellular Therapy Group (GETH).

European journal of radiology

Review of imaging findings in hepatic veno-occlusive disease.

Veno-Occlusive Disease: A Life-saving Novel Approach With Plasma Exchange, IVIG, and Steroid, Without Defibrotide.

Journal of global antimicrobial resistance

Sepsis and pneumonia caused by Enterococcus faecium following liver transplantation treated with contezolid as the first-line therapy.

6-Mercaptopurine-associated Sinusoidal Obstructive Syndrome During Interim Maintenance I: A Case Report.

Shear wave elastography and dispersion imaging for hepatic veno-occlusive disease prediction after pediatric hematopoietic stem cell transplantation: a feasibility study.

Pediatric radiology

Functional metabolomics characterizes the contribution of farnesoid X receptor in pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome.

Archives of toxicology

Liver stiffness measurements predict Sinusoidal Obstructive Syndrome after hematopoietic stem cell transplantation.

Diagnosing and Grading of Sinusoidal Obstructive Syndrome after Hematopoietic Stem Cell Transplant of Children, Adolescent and Young Adults treated in a Pediatric Institution with Pediatric Protocols.

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

[Role of liver sinusoidal endothelial cell damage in the developmental process of hepatic sinusoidal obstruction syndrome: a focus on the research progress of immune inflammatory mechanisms].

Evaluation of Circulating Endothelial Cells as Direct Marker of Endothelial Damage in Allo-Transplant Recipients at High Risk of Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome.

Hepatic veno-occlusive disease complicated with extreme hyperammonaemia (920 µmol/L) treated with defibrotide, lactulose, rifampin and haemodialysis.

BMJ case reports

Autotaxin is a potential predictive marker for the development of veno-occlusive disease/sinusoidal obstruction syndrome after allogeneic hematopoietic cell transplantation.

Annals of hematology

Gynura segetum induces hepatic sinusoidal obstruction syndrome in a child: A case report.

Medicine

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis

Clinical features and risk factors of hepatic sinusoidal obstruction syndrome in children after hematopoietic stem cell transplantation: A single-center experience.

Bile cast nephropathy after sinusoidal obstruction syndrome.

Kidney international

Pakistan journal of medical sciences

Incidence, management and outcome of Hepatic Veno-Occlusive disease /Sinusoidal Obstruction Syndrome after hematopoietic stem cell transplant in Thalassemia major patients: A prospective study of Pakistani BMT.

Journal of gastroenterology and hepatology

Cilostazol improves the prognosis after hepatectomy in rats with sinusoidal obstruction syndrome.

Anticoagulant therapy likely increases risk of bleeding in Gynura segetum-induced hepatic sinus obstruction syndrome.

Medicine

The journal of applied laboratory medicine

Evaluation of Busulfan as a Third-Party Immunoassay on a Clinical Chemistry Analyzer.

Multiplex Proteomics in the Identification of Potential Biomarkers of Very Severe Sinusoidal Obstruction Syndrome/Veno-Occlusive Disease in Allogeneic Hematopoietic Cell Transplant Patients Treated with Defibrotide.

Acta haematologica

Utility of the refined EBMT diagnostic and severity criteria 2023 for sinusoidal obstruction syndrome/veno-occlusive disease.

Incidence and risk factors of early onset VOD/SOS differ in younger vs older adults after stem cell transplantation.

Blood advances

Azathioprine-induced Veno-occlusive Hepatotoxicity in a Patient with Myasthenia Gravis.

Current drug safety

Gemtuzumab Ozogamicin in Acute Myeloid Leukemia: Efficacy, Toxicity, and Resistance Mechanisms-A Systematic Review.

Biomedicines

Journal of clinical pathology

Dissociation in hepatic vein pressure gradient, liver stiffness measurement and complications in histological subtypes of porto-sinusoidal vascular disease.

Journal of cancer research and clinical oncology

Analysis of laboratory parameters before the occurrence of hepatic sinusoidal obstruction syndrome in children, adolescents, and young adults after hematopoietic stem cell transplantation.

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi

[Treatment response of a two-dose regimen of dose-adjusted inotuzumab ozogamicin in relapsed/refractory B-cell acute lymphoblastic leukemia].

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

Histological evaluation of pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome: Correlation with Drum Tower Severity Scoring.

Journal of medical ultrasonics (2001)

Utility of liver stiffness measurement in the diagnosis of sinusoidal obstruction syndrome/veno-occlusive disease after hematopoietic stem cell transplantation.

Clinical outcomes of early defibrotide discontinuation: a single-center case series.

Impact of inotuzumab ozogamicin on outcome in relapsed or refractory acute B-cell lymphoblastic leukemia patients prior to allogeneic hematopoietic stem cell transplantation and risk of sinusoidal obstruction syndrome/venous occlusive disease.

Haematologica

Early-onset hepatic veno-occlusive disease after liver transplantation: an institutional experience and analysis of a literature-based cohort.

Surgery today

Current medical research and opinion

Primary Budd-Chiari syndrome versus sinusoidal obstruction syndrome: a review.

International journal of molecular sciences

Assaying ADAMTS13 Activity as a Potential Prognostic Biomarker for Sinusoidal Obstruction Syndrome in Mice.

Ultrasound in medicine & biology

Prospective Assessment of Treatment-Induced Liver Injury as a Cause of Diffuse Pathologic Hepatic Enhancement in Contrast-Enhanced Ultrasound.

Rifaximin Prevents Intestinal Barrier Dysfunction and Alleviates Liver Injury in MCT-induced HSOS Mice.

Current medical science

Phase 2 study of inotuzumab ozogamicin for measurable residual disease in acute lymphoblastic leukemia in remission.

Blood

Constructing training set using distance between learnt graphical models of time series data on patient physiology, to predict disease scores.

PloS one

Internal medicine (Tokyo, Japan)

Post-allogeneic Hematopoietic Stem Cell Transplantation Portal Hypertension Not Associated with Liver Cirrhosis, Veno-occlusive Disease, or Graft-versus-host Disease.

HokUS-10 scoring system predicts the treatment outcome for sinusoidal obstruction syndrome after allogeneic hematopoietic stem cell transplantation.

Scientific reports

Cell biology and toxicology

Andrographolide attenuated MCT-induced HSOS via regulating NRF2-initiated mitochondrial biogenesis and antioxidant response.

Rare variants in complement system genes associate with endothelial damage after pediatric allogeneic hematopoietic stem cell transplantation.

Frontiers in immunology

Diagnosis of sinusoidal obstruction syndrome: can biopsy be the key?

Annals of hematology

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

[Evaluation of the efficacy of TIPS in 27 patients with hepatic sinus obstruction syndrome in the near and medium term].

Clinics and research in hepatology and gastroenterology

Transjugular Intrahepatic Portosystemic Shunt is effective to treat portal hypertension due to sinusoidal obstructive syndrome.

Toxicology in vitro : an international journal published in association with BIBRA

Busulfan-induced hepatic sinusoidal endothelial cell injury: Modulatory role of pirfenidone for therapeutic purposes.

Current incidence, severity, and management of veno-occlusive disease/sinusoidal obstruction syndrome in adult allogeneic HSCT recipients: an EBMT Transplant Complications Working Party study.

Prognostic risk factors for patients with hepatic sinusoidal obstruction syndrome caused by pyrrolizidine alkaloids.

Medicine

Hematology (Amsterdam, Netherlands)

Retrospective study of risk factors for pericardial effusion after haematopoietic stem cell transplantation in children.

Surgical pathology clinics

Liver Pathology After Hematopoietic Stem Cell Transplantation.

Concordance between HokUS-10 Scoring and Transjugular Liver Biopsy for the Diagnosis of Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome after Allogeneic Stem Cell Transplantation.

[Rinsho ketsueki] The Japanese journal of clinical hematology

[Posttransplant complications: GVHD and SOS/VOD].

Defibrotide prophylaxis for prevention of sinusoidal obstruction syndrome - Authors' reply.

Defibrotide prophylaxis for prevention of sinusoidal obstruction syndrome.

Journal of medical ultrasonics (2001)

Assessment of hepatic veno-occlusive disease/sinusoidal obstruction syndrome using different scanning approaches for the ultrasonographic evaluation of portal vein blood flow and hepatic artery resistive index in hematopoietic stem cell transplant recipients.

A phase 2 trial of defibrotide for the prevention of chimeric antigen receptor T-cell-associated neurotoxicity syndrome.

Blood advances

European journal of gastroenterology & hepatology

Transjugular intrahepatic portosystemic shunt for pyrrolidine alkaloids-induced hepatic sinusoidal obstruction syndrome: a retrospective cohort study.

Point shear-wave elastography for the diagnosis of veno-occlusive disease in children and young adults.

Pediatric radiology

Hematology/oncology and stem cell therapy

Peritoneal and Pleural Drains in Pediatric Hematopoietic Cell Transplant Recipients with Veno-Occlusive Disease are Safe and Do Not Adversely Impact Clinical Outcomes.

Journal of biochemical and molecular toxicology

Melatonin attenuates monocrotaline-induced hepatic sinusoidal obstruction syndrome in rats via activation of Sirtuin-3.

Prevention of veno-occlusive disease/sinusoidal obstruction syndrome: a never-ending story and no easy answer.

Cardiovascular and interventional radiology

Transjugular Intrahepatic Portosystemic Shunt Benefits for Hepatic Sinusoidal Obstruction Syndrome Associated with Consumption of Gynura Segetum: a Propensity Score-Matched Analysis.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

Sinusoidal obstruction syndrome associated with disseminated toxoplasmosis involving the liver after allogeneic hematopoietic stem cell transplantation: A case report.

Thymosin β4 Exerts a Cytoprotective Function and Attenuates Liver Injury in Murine Hepatic Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation.

Mini-hyper-CVD plus inotuzumab ozogamicin, with or without blinatumomab, in the subgroup of older patients with newly diagnosed Philadelphia chromosome-negative B-cell acute lymphocytic leukaemia: long-term results of an open-label phase 2 trial.

Sinusoidal Obstruction Syndrome (SOS) and Defibrotide: We Are Not There Yet.

Life (Basel, Switzerland)

The Role of the Transjugular Intrahepatic Porto-Systemic Shunt in an Emergency Setting.

Low Plasma Levels of Hyaluronic Acid Might Rule Out Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation.

Disease markers

Diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a refined classification from the European society for blood and marrow transplantation (EBMT).

Journal of cancer research and clinical oncology

Hypofibrinolysis in pediatric patients with veno-occlusive disease in hematopoietic stem cell transplantation.

Prospective assessment of risk biomarkers of sinusoidal obstruction syndrome after hematopoietic cell transplantation.

JCI insight

A novel integrative multi-omics approach to unravel the genetic determinants of rare diseases with application in sinusoidal obstruction syndrome.

PloS one

Can defibrotide prophylaxis prevent sinusoidal obstruction syndrome following haematopoietic stem-cell transplantation?

Defibrotide plus best standard of care compared with best standard of care alone for the prevention of sinusoidal obstruction syndrome (HARMONY): a randomised, multicentre, phase 3 trial.

International journal of molecular sciences

Molecular Advances in Sinusoidal Obstruction Syndrome/Veno-Occlusive Disease.

Ultrasonography (Seoul, Korea)

Usefulness of two-dimensional shear wave elastography in diagnosing hepatic veno-occlusive disease in pediatric patients undergoing hematopoietic stem cell transplantation.

Incidence of Sinusoidal Obstruction Syndrome/Veno-Occlusive Disease and Treatment with Defibrotide in Allogeneic Transplantation: A Multicenter Australasian Registry Study.

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

[Research progress of hepatic sinusoidal obstruction syndrome].

Therapeutic advances in hematology

Update on the role of gemtuzumab-ozogamicin in the treatment of acute myeloid leukemia.

Biomarkers for early complications post hematopoietic cell transplantation: Insights and challenges.

Frontiers in immunology

Hepatic Veno-occlusive disease (VOD) in multiple myeloma patient receiving Belantamab Mafodotin.

Leukemia & lymphoma

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment

Risk assessment of short-term intake of pyrrolizidine alkaloids in food: derivation of an acute reference dose.

Gan to kagaku ryoho. Cancer & chemotherapy

[A Case of Sinusoidal Obstruction Syndrome and Nodular Regenerative Hyperplasia after Using Oxaliplatin for Rectal Cancer].

European journal of gastroenterology & hepatology

Mid- to long-term outcomes of initial transjugular intrahepatic portosystemic shunt versus anticoagulation for pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome.

Post-Transplantation Sinusoidal Obstruction Syndrome in Adult Patients with B Cell Acute Lymphoblastic Leukemia Treated with Pretransplantation Inotuzumab.

Expert review of gastroenterology & hepatology

Hepatobiliary disease after bone marrow transplant.

Journal of clinical medicine

Differential Diagnosis of Hyperferritinemia in Critically Ill Patients.

Interprofessional Team-based Care of the Hematopoietic Cell Transplantation Patient With Hepatic Veno-occlusive Disease/Sinusoidal Obstruction Syndrome.

Vascular and endovascular surgery

Transjugular Intrahepatic Portosystemic Shunt in Liver Transplant Recipients: Outcomes in Six Adult Patients.

International journal of clinical oncology

Predictive factors of collateral vessel development induced by oxaliplatin-based chemotherapy.

Prognostic Biomarkers for Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome in Myeloablative Allogeneic Hematopoietic Cell Transplantation: Results from the Blood and Marrow Transplant Clinical Trials Network 1202 Study.

Real-world use of defibrotide for veno-occlusive disease/sinusoidal obstruction syndrome: the DEFIFrance Registry Study.

Defibrotide improved the outcome of monocrotaline induced rat hepatic sinusoidal obstruction syndrome.

BMC gastroenterology

Journal of clinical laboratory analysis

Effects of bicyclol on hepatic sinusoidal obstruction syndrome induced by Gynura segetum.

Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology

Plugged percutaneous liver biopsy using Tru-cut needle and coils: A retrospective study.

Modern rheumatology case reports

Hepatic veno-occlusive disease accompanied by thrombotic microangiopathy developed during treatment of juvenile dermatomyositis and macrophage activation syndrome: A case report.

Liver international : official journal of the International Association for the Study of the Liver

Enoxaparin attenuates pyrrolizidine alkaloids-induced hepatic sinusoidal obstruction syndrome by inhibiting oncostatin M expression.

Frontiers in transplantation

Systematic screening and focused evaluation for veno-occlusive disease/sinusoidal obstructive syndrome (VOD/SOS) following allogeneic stem cell transplant is associated with earlier diagnosis and prompt institution of defibrotide treatment.

Ultrasonographic monitoring of sinusoidal obstruction syndrome in patients treated with inotuzumab ozogamicin.

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics

[Risk factors for acute kidney injury after hematopoietic stem cell transplantation in children: a retrospective study].

Molecular medicine reports

Model establishment and microarray analysis of mice with oxaliplatin‑induced hepatic sinusoidal obstruction syndrome.

BioMed research international

A Retrospective Cohort Study of the Efficacy, Safety, and Clinical Value of 6-TG versus 6-MP Maintenance Therapy in Children with Acute Lymphoblastic Leukemia.

International journal of clinical oncology

Usefulness of ultrasonography and elastography in diagnosing oxaliplatin-induced sinusoidal obstruction syndrome.

Sinusoidal Obstruction Syndrome of the Liver Associated With 6-Mercaptopurine During Maintenance in a Child With T-cell Acute Lymphoblastic Leukemia.

Mini-hyper CVD + CRIB (condensed rituximab, inotuzumab ozogamicin, and blinatumomab) for refractory pediatric B-acute lymphoblastic leukemia.