A encefalopatia responsiva a esteróides associada à tireoidite autoimune (SREAT) é uma doença neurológica adquirida rara, caracterizada por encefalopatia associada a anticorpos antitireoidianos elevados, na ausência de outras causas. A apresentação clínica varia desde comprometimento cognitivo menor até estado de mal epiléptico e coma, e frequentemente inclui convulsões, confusão, distúrbios da fala, comprometimento da memória, ataxia e manifestações psiquiátricas.
Introdução
O que você precisa saber de cara
A encefalopatia responsiva a esteróides associada à tireoidite autoimune (SREAT) é uma doença neurológica adquirida rara, caracterizada por encefalopatia associada a anticorpos antitireoidianos elevados, na ausência de outras causas. A apresentação clínica varia desde comprometimento cognitivo menor até estado de mal epiléptico e coma, e frequentemente inclui convulsões, confusão, distúrbios da fala, comprometimento da memória, ataxia e manifestações psiquiátricas.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 8 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 25 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Nenhum gene associado encontrado
Os dados genéticos desta condição ainda estão sendo catalogados.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Encefalite sensível aos esteroides associada a tireoidite autoimune
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Ensaios clínicos abertos e novidades científicas recentes
Pesquisa e ensaios clínicos
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Publicações mais relevantes
Steroid-responsive encephalopathy associated with autoimmune thyroiditis.
Hashimoto encephalopathy or steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT) is a rare condition associated with rapidly progressive dementia, stroke-like symptoms, psychosis and positive antithyroid antibodies. In this case report, a woman in her 80s with hypothyroidism and no other medically relevant history presented with a 2-week complaint of progressive hallucinations, short-term memory loss and paranoia. Eventually hospitalised, her hospital course was complicated by severe hospital-acquired delirium, which clouded the clinical picture; however, initial workup revealed an elevated thyroglobulin antibody and thyroid peroxidase, both highly specific for SREAT. A 3-day course of high-dose methylprednisolone (1 g/day) was administered, which revealed marked improvement in patient symptoms. Definitive treatment included a 13-week oral prednisone taper and outpatient follow-up with neurology and primary care. In cases of new onset neuropsychiatric symptoms in geriatric populations, SREAT is a reversible, must-not-miss diagnosis, when treated with systemic steroids.
Steroid Responsive Encephalopathy Associated with Autoimmune Thyroiditis (SREAT): Authors' Reply.
Steroid Responsive Encephalopathy Associated with Autoimmune Thyroiditis (SREAT): Correspondence.
Steroid Responsive Encephalopathy Associated with Autoimmune Thyroiditis (SREAT).
Hashimoto's encephalopathy presenting with manic and psychotic features in a 13-year-old girl: a case report.
Hashimoto's encephalopathy (HE), also known as steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT), is a rare autoimmune neuropsychiatric syndrome with highly variable clinical manifestations. Pediatric cases are particularly underrecognized, contributing to diagnostic delays. We describe a 13-year-old female patient who developed subacute behavioral changes, including withdrawal, emotional lability, and progressive manic and psychotic symptoms, over 1 month. Laboratory evaluation showed markedly elevated antithyroid antibodies with normal thyroid hormone levels, and thyroid ultrasound revealed features consistent with autoimmune thyroiditis. Neuroimaging and cerebrospinal fluid studies were unremarkable. The patient demonstrated rapid and sustained improvement following pulse corticosteroids, intravenous immunoglobulin (IVIG), and low-dose antipsychotics. Her clinical course, combined with serological and imaging findings, supported the diagnosis of HE presenting with manic and psychotic features. This case emphasizes the importance of considering HE in the differential diagnosis of acute and subacute onset psychiatric symptoms in children and highlights the diagnostic utility of thyroid antibody testing in such presentations. Categories: Pediatrics; Psychiatry; Neurology; Endocrinology; Immunology.
Publicações recentes
Super refractory status epilepticus as an atypical presentation of Hashimoto's encephalopathy.
Hashimoto's encephalopathy presenting with manic and psychotic features in a 13-year-old girl: a case report.
Primary Central Nervous System Lymphoma: A Case Report of the Neurological Great Mimicker.
Hashimoto's Encephalopathy as a Cause of Persistent Myoclonic Jerks: A Report of a Unique Case.
Hashimoto's encephalopathy in psychiatric inpatients: neuropsychiatric morbidity, diagnostic challenges and treatment.
📚 EuropePMC42 artigos no totalmostrando 68
Hashimoto's encephalopathy presenting with manic and psychotic features in a 13-year-old girl: a case report.
Frontiers in psychiatryPrimary Central Nervous System Lymphoma: A Case Report of the Neurological Great Mimicker.
CureusHashimoto's Encephalopathy as a Cause of Persistent Myoclonic Jerks: A Report of a Unique Case.
CureusHashimoto's encephalopathy in psychiatric inpatients: neuropsychiatric morbidity, diagnostic challenges and treatment.
Frontiers in psychiatrySteroid-responsive encephalopathy associated with autoimmune thyroiditis.
BMJ case reportsBeyond Pediatric Sleep Disorders: A Case of Hypersomnia Revealing Hashimoto's Encephalopathy.
CureusManaging Hashimoto's Encephalopathy: A Case Report.
CureusHashimoto's Encephalopathy: Clinical Features, Therapeutic Strategies, and Rehabilitation Approaches.
BiomedicinesSteroid Responsive Encephalopathy Associated with Autoimmune Thyroiditis (SREAT): Authors' Reply.
Indian journal of pediatricsWhen thyroid met brain: the enigma of steroid responsive encephalopathy associated with autoimmune thyroiditis a case report.
Frontiers in immunologySteroid Responsive Encephalopathy Associated with Autoimmune Thyroiditis (SREAT): Correspondence.
Indian journal of pediatricsSteroid Responsive Encephalopathy Associated with Autoimmune Thyroiditis (SREAT).
Indian journal of pediatricsA Challenging Diagnosis of Steroid-Responsive Encephalopathy Associated With Autoimmune Thyroiditis (SREAT) in a Systemic Lupus Erythematosus (SLE) Patient With Hashimoto Encephalopathy (HE): A Case Report.
CureusAn Intriguing Case of Delirium: Recognizing Steroid-Responsive Encephalopathy Associated With Autoimmune Thyroiditis.
CureusHashimoto encephalopathy: a literature review and case report with comprehensive neuropsychological evaluation.
The Clinical neuropsychologistDifficulties in the Diagnostics and Treatment of Hashimoto's Encephalopathy-A Systematic and Critical Review.
International journal of molecular sciencesSteroid responsive encephalopathy associated with autoimmune thyroiditis (SREAT) presenting as subacute psychosis: Case report and literature review.
Clinical case reportsA Prospective Observational Study of Autoimmune Encephalitis in Northwestern India.
The Journal of the Association of Physicians of IndiaSteroid-Responsive Encephalopathy Associated With Autoimmune Thyroiditis Presenting With Parkinsonism.
Cureus[Steroid responsive encephalopathy associated with autoimmune thyroiditis as a cause of acuteencephalopathy].
Vnitrni lekarstviThe use of intravenous immunoglobulin in the treatment of Hashimoto's encephalopathy: case based review.
Frontiers in neurologySteroid-responsive encephalopathy associated with autoimmune thyroiditis presenting as cortisone sensible psychosis with reversible leukoencephalopathy.
Journal of neuroimmunologySteroid-Responsive Encephalopathy Associated With Autoimmune Thyroiditis Masquerading Sepsis.
CureusThyroid Disorders and Movement Disorders-A Systematic Review.
Movement disorders clinical practiceHashimoto's Encephalopathy: Case Series and Literature Review.
Current neurology and neuroscience reportsMRI and steroid-responsive encephalopathy associated with autoimmune thyroiditis: first report of conus medullaris involvement and literature review of the known neuroimaging profiles.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical NeurophysiologyCerebellar Ataxia in the Setting of Hashimoto's Thyroiditis: A Case Report.
CureusAutoimmune Encephalopathy Associated With Anti-thyroid Antibodies: A Case Report.
CureusHashimoto's encephalopathy with cerebellar ataxia as the main symptom: A case report and literature review.
Frontiers in neurologyTreatable Ataxias: How to Find the Needle in the Haystack?
Journal of movement disordersTwo PerPLEXing Cases of Hashimoto's Encephalopathy Unresponsive to Steroid and Intravenous Immunoglobulin Therapy.
CureusLingering Effects: Hashimoto's Encephalopathy.
CureusSteroid-responsive encephalopathy associated with autoimmune thyroiditis presenting with a postpartum psychosis.
BMJ case reportsHashimoto's Encephalopathy Masquerading as Rapidly Progressive Dementia and Extrapyramidal Failure.
Journal of neurosciences in rural practiceAmino acid sequence homology between thyroid autoantigens and central nervous system proteins: Implications for the steroid-responsive encephalopathy associated with autoimmune thyroiditis.
Journal of clinical & translational endocrinology[Hashimoto's encephalopathy-An underdiagnosed disease in psychiatry?].
Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und PsychiaterA Case of Euthyroid Steroid-Responsive Encephalopathy With Subacute Dementia.
CureusMRI Findings of Two Patients With Hashimoto Encephalopathy.
CureusBrain dysfunction and thyroid antibodies: autoimmune diagnosis and misdiagnosis.
Brain communicationsHashimoto's encephalopathy: A rare cause of refractory status epilepticus.
CNS neuroscience & therapeuticsPatients with a relapsing course of steroid-responsive encephalopathy associated with autoimmune thyroiditis exhibit persistent intrathecal CD4+ T-cell activation.
European journal of neurologySerum anti-thyroid antibody titers correlate with severity of illness in steroid-responsive encephalopathy associated with autoimmune thyroiditis.
The Australian and New Zealand journal of psychiatryAttempted Suicide in a Woman With Steroid-responsive Encephalopathy Associated With Autoimmune Thyroiditis: A Case Report.
Journal of psychiatric practiceHashimoto's Encephalopathy: Back to Square One.
Movement disorders clinical practiceAnti-Thyroid Peroxidase/Anti-Thyroglobulin Antibody-Related Neurologic Disorder Responsive to Steroids Presenting with Pure Acute Onset Chorea.
Tremor and other hyperkinetic movements (New York, N.Y.)Echolalia: Presentation of Steroid-Responsive Encephalopathy Associated with Autoimmune Thyroiditis.
Indian journal of pediatricsHashimoto's encephalopathy in association with retinitis pigmentosa - First reported case.
Journal of family medicine and primary careA young man with convulsive laughter.
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekkeHashimoto's encephalopathy: Follow-up data from neuropsychology, lumbar puncture, and FDG-PET.
Clinical case reportsSREAT presenting as decades of intractable seizures and isolated delusional episodes with clinical, laboratory, and EEG confirmation of treatment response.
SAGE open medical case reportsRelapsing encephalopathy with dancing eyes and jerky limbs.
Parkinsonism & related disordersPsychotic Symptoms of Hashimoto's Encephalopathy: A Diagnostic Challenge.
Soa--ch'ongsonyon chongsin uihak = Journal of child & adolescent psychiatryCurrent knowledge on Hashimoto's encephalopathy: a literature review.
MedwaveSteroid-responsive encephalopathy with a peculiar CSF biomarker profile in an 89-year-old man.
Oxford medical case reportsSteroid-responsive Encephalopathy Associated with Autoimmune Thyroiditis (SREAT) Presenting with Pure Cerebellar Ataxia.
Tremor and other hyperkinetic movements (New York, N.Y.)Steroid-Responsive Encephalopathy Associated with Autoimmune Thyroiditis Presenting with Fever and Confusion.
Case reports in neurological medicineCerebellopathy secondary to anti-peroxidase antibody-mediated toxicity. A special case of Hashimoto encephalopathy.
Journal of neuroimmunologyHashimoto encephalopathy in pediatric patients: Homogeneity in clinical presentation and heterogeneity in antibody titers.
Brain & developmentSteroid-Responsive Chronic Schizophreniform Syndrome in the Context of Mildly Increased Antithyroid Peroxidase Antibodies.
Frontiers in psychiatryNonconvulsive Status Epilepticus Resembling Clinical Absence with Atypical EEG Pattern.
Case reports in neurological medicineProminent Bilateral Hand Tremor in Hashimoto's Encephalopathy: A Video Demonstration.
Tremor and other hyperkinetic movements (New York, N.Y.)Delirious Mania Associated with Autoimmune Gastrothyroidal Syndrome of a Mid-Life Female: The Role of Hashimoto Encephalopathy and a 3-Year Follow-Up including Serum Autoantibody Levels.
Case reports in psychiatryAutoimmune Schizophrenia? Psychiatric Manifestations of Hashimoto's Encephalitis.
CureusSteroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT): Characteristics, treatment and outcome in 251 cases from the literature.
Autoimmunity reviewsSteroid responsive encephalopathy associated with autoimmune thyroiditis (SREAT) presenting as major depression.
BMC psychiatryAutoimmune dementia and encephalopathy.
Handbook of clinical neurologyOcular flutter and ataxia without cognitive impairment associated with steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT).
Journal of the neurological sciencesSteroid responsive encephalopathy associated with autoimmune thyroiditis following ipilimumab therapy: a case report.
BMC research notesAssociações
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Steroid-responsive encephalopathy associated with autoimmune thyroiditis.
- Steroid Responsive Encephalopathy Associated with Autoimmune Thyroiditis (SREAT): Authors' Reply.
- Steroid Responsive Encephalopathy Associated with Autoimmune Thyroiditis (SREAT): Correspondence.
- Steroid Responsive Encephalopathy Associated with Autoimmune Thyroiditis (SREAT).
- Hashimoto's encephalopathy presenting with manic and psychotic features in a 13-year-old girl: a case report.
- Super refractory status epilepticus as an atypical presentation of Hashimoto's encephalopathy.
- Primary Central Nervous System Lymphoma: A Case Report of the Neurological Great Mimicker.
- Hashimoto's Encephalopathy as a Cause of Persistent Myoclonic Jerks: A Report of a Unique Case.
- Hashimoto's encephalopathy in psychiatric inpatients: neuropsychiatric morbidity, diagnostic challenges and treatment.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:83601(Orphanet)
- MONDO:0019385(MONDO)
- GARD:8570(GARD (NIH))
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
- Q4532132(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
