Anormalidade congênita que consiste em uma abertura ou lacuna na face, que resulta da fusão incompleta de uma ou mais proeminências faciais embrionárias.
Introdução
O que você precisa saber de cara
Anormalidade congênita que consiste em uma abertura ou lacuna na face, que resulta da fusão incompleta de uma ou mais proeminências faciais embrionárias.
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Preparando trilha educativa...
Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 2 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 21 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
3 genes identificados com associação a esta condição.
Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development
Secreted, extracellular space, extracellular matrix, basement membrane
Bifid nose, with or without anorectal and renal anomalies
A disease characterized by the presence of a bifid nose usually associated with renal agenesis and anorectal malformations. A bifid nose is a congenital deformity due to failure of the paired nasal processes to fuse to a single midline organ during early gestation.
Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration
Cytoplasm, cytoskeletonCytoplasm, cytoskeleton, spindleCell junction, gap junction
Facial clefting, oblique, 1
A rare form of facial clefting. A facial cleft is any of the fissures between the embryonic prominences that normally unite to form the face.
Plays a role in the control of cellular growth (PubMed:18285427). May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH)
Membrane
Medulloblastoma
Malignant, invasive embryonal tumor of the cerebellum with a preferential manifestation in children.
Variantes genéticas (ClinVar)
1,990 variantes patogênicas registradas no ClinVar.
Vias biológicas (Reactome)
1 via biológica associada aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Fenda facial
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Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
Pesquisa e ensaios clínicos
7 ensaios clínicos encontrados.
Publicações mais relevantes
Midline congenital upper lip sinus: a rare clinical case with analytical review of diagnostic and therapy strategies.
Congenital midline sinus of the upper lip is rarest malformation with or without other anomalies. Mostly the sinus opens below the white role on the vermilion and has no intra-oral communication. To date, there have been only several case reports of upper lip sinuses associated with other anomalies, such as cleft palate or transverse facial cleft in China. We herein present a case of congenital upper lip sinus in the middle of the philtrum presenting as whitish discharge used to come out of it and review the current literature on this condition.
Perioperative Care of a Four-Year-Old Child With Teebi Hypertelorism Syndrome: A Rare Craniofacial Disorder.
Teebi hypertelorism syndrome (THS) is a rare, autosomal dominant craniofacial malformation disorder, characterized by orbital hypertelorism and characteristic craniofacial features, including a prominent forehead, wide arched eyebrows, short broad nasal root and tip, a thin upper lip, and a small chin. In addition to the characteristic phenotypic traits, systemic malformations may involve the limbs, central nervous system, urogenital tract, uterus, umbilicus (omphalocele), or cardiac system. Most cases can now be attributed to pathogenic variants in the SPECC1L gene on chromosome 22q11.23, leading to what is known as SPECC1L-related hypertelorism syndrome, which is associated with disruption of a cytoskeletal cross-linking protein. This protein is crucial for normal craniofacial morphogenesis during neural crest cell migration and midline facial formation. To date, there are no previous reports of anesthetic care in a patient with THS. We present a 4-year-old child with THS who presented for anesthetic care during thoracic laminectomy and excision of an intradural mass. We explore the history and clinical presentation of the disorder, outline end-organ involvement, and discuss perioperative concerns.
Transverse facial cleft repair: Preventing pigmentation around the postoperative scar by excising the pigmented white lip at the cleft margin-A retrospective case series of Japanese patients.
Numerous transverse facial cleft repair techniques and designs have been described; however, a complication of surgical reconstruction is scar formation with brown discoloration. This study investigated the histological basis of the darker white lip at the cleft margin, its role in postoperative brown discoloration, and the potential esthetic benefits of extending the excision. In this retrospective analysis, patients with transverse facial cleft were divided into limited and extended excision groups. Histological assessment of melanin pigment was performed using Fontana-Masson staining, and postoperative buccal scars were evaluated from photographs using the Stony Brook Scar Evaluation Scale. The Mann-Whitney U test was used for statistical analysis. We divided 16 Japanese patients (4 boys and 12 girls) into limited (n = 9) and extended excision groups (n = 7). The cleft length was 8.6 ± 2.1 and 8.9 ± 3.3 mm in the limited and extended excision groups, respectively, with unilateral/bilateral laterality being 9/0 and 6/1, respectively. Initial surgeries for both groups were performed at 11.4 ± 8.4 and 8.3 ± 7.7 months, and scar evaluations were based on photographs obtained at 47.8 ± 13.5 and 27.1 ± 14.2 months, respectively. Histology showed increased melanin in the darker area of the white lip at the cleft margin, with markedly reduced pigment density in the normal-toned area. The extended excision group had less colored scar than the limited excision group (p < 0.05). Incorporating pericleft pigmentation excision into surgical design may reduce postoperative periscar hyperpigmentation and improve esthetic outcomes for several years.
Bilateral Cheilorhinoplasty Techniques May Be Applied to an Incomplete Rare Facial Cleft: Case Report and Literature Review.
Tessier 0, or midline facial clefts, is one of the most common presentations among craniofacial clefts; however, there may be a diverse severity in presentations. This report applies established methods in bilateral lip repair to an incomplete Tessier 0 presentation. The report reviews literature available on midline facial clefts and contrasts the proposed application with a single straight-line repair. Tessier 0 clefts are rare, with an estimated incidence ranging from 1.4 to 4.9 per 100,000 live births. About 80 cases have been described in the literature; however, these may be underreported. Standard bilateral cheilorhinoplasty techniques previously described may be used for these relatively rare cases. The application of established methods for bilateral cleft lip/nose primary care may be performed for variants of rare facial clefting.
Modiolus-Based Dynamic Reconstruction for Transverse Facial Cleft: A Retrospective Cohort Study.
Transverse facial cleft is a rare congenital craniofacial anomaly that significantly impacts both aesthetic appearance and functional integrity of the oral commissure. Current surgical techniques demonstrate suboptimal efficacy in restoring commissural morphology and facial symmetry. To further optimize surgical outcomes, we enhanced the conventional approach by incorporating anatomical reconstruction of the modiolus and orbicularis oris, and evaluated its long-term aesthetic outcomes in the symmetry of commissure compared with conventional methods. This single-center cohort study retrospectively analyzed 20 patients who underwent unilateral transverse facial cleft repair between May 2015 and October 2023. The cohort comprised two groups: (1) conventional repair group (n=9) and (2) priority modiolus reconstruction group (n=11). Objective anthropometric measurements were obtained at preoperative, immediate postoperative, and long-term follow-up stages. Subjective evaluations were performed using Face-Q and Visual Analog Scale (VAS) questionnaires. Immediate postoperative assessment revealed significant improvement in the lower cheilion spread angle (ΔLCSA) in the modiolus reconstruction group compared to controls (8.22 ± 5.43 vs. 3.67 ± 2.99, p = 0.045). Long-term follow-up demonstrated significant differences in four key perioral measurements: ΔUCSA (10.04 ± 6.83 vs. 4.56 ± 1.78, p = 0.046), ΔLCSA (9.47 ± 5.19 vs. 3.94 ± 2.78, p = 0.014), ΔLs-Ch (9.75 ± 5.91 vs. 3.82 ± 1.95, p = 0.004) and Δl-Ch (10.59 ± 5.41 vs. 3.89 ± 3.32, p = 0.006), indicating enhanced commissural symmetry, particularly during mouth-opening. Professional evaluation using VAS for commissural symmetry were also significantly higher in the reconstruction group at long-term follow-up (7.78 ± 0.75 vs. 8.45 ± 0.58, p = 0.042). In patients with unilateral transverse facial cleft, priority modiolus reconstruction is associated with superior static and dynamic symmetry of commissure compared with conventional repair, with maintained long-term outcomes.
Publicações recentes
Midline congenital upper lip sinus: a rare clinical case with analytical review of diagnostic and therapy strategies.
Perioperative Care of a Four-Year-Old Child With Teebi Hypertelorism Syndrome: A Rare Craniofacial Disorder.
Transverse facial cleft repair: Preventing pigmentation around the postoperative scar by excising the pigmented white lip at the cleft margin-A retrospective case series of Japanese patients.
Bilateral Cheilorhinoplasty Techniques May Be Applied to an Incomplete Rare Facial Cleft: Case Report and Literature Review.
Modiolus-Based Dynamic Reconstruction for Transverse Facial Cleft: A Retrospective Cohort Study.
📚 EuropePMC221 artigos no totalmostrando 196
Midline congenital upper lip sinus: a rare clinical case with analytical review of diagnostic and therapy strategies.
Frontiers in pediatricsPerioperative Care of a Four-Year-Old Child With Teebi Hypertelorism Syndrome: A Rare Craniofacial Disorder.
Journal of medical casesTransverse facial cleft repair: Preventing pigmentation around the postoperative scar by excising the pigmented white lip at the cleft margin-A retrospective case series of Japanese patients.
JPRAS openBilateral Cheilorhinoplasty Techniques May Be Applied to an Incomplete Rare Facial Cleft: Case Report and Literature Review.
Plastic and reconstructive surgery. Global openModiolus-Based Dynamic Reconstruction for Transverse Facial Cleft: A Retrospective Cohort Study.
Plastic and reconstructive surgeryManagement of tessier cleft 7: A case report.
National journal of maxillofacial surgeryChallenges and Outcomes of Rare Cranio Facial Clefts: Parents Perspective.
Journal of maxillofacial and oral surgeryFacial Clefts and the Trigeminal Nerve: A Narrative Review of the Literature and Clinical Considerations in the Era of Personalized Medicine.
Journal of personalized medicineOverexpression of miR-320-3p, miR-381-3p, and miR-27a-3p Suppresses Genes Related to Midline Facial Cleft in Mouse Cranial Neural Crest Cells.
International journal of molecular sciencesUnilateral Craniofacial Microsomia with Severe Tessier No. 7 Cleft and Mandibular Agenesis: A Rare Case Report.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationLong-Term Follow-Up of the Patients With Combined Tessier Number 7 Cleft and Unilateral Cleft Lip.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationThe Presentation Patterns of Tessier 7 Clefts.
The Journal of craniofacial surgeryFoundation and Innovation in Lip, Palate, and Facial Cleft Care.
Facial plastic surgery clinics of North AmericaMastering the Art of Symmetry: Long-Term Outcomes and Management in Patients with Tessier No. 7 Cleft.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationUncovering the hidden hunger in translational research for periconceptional folic acid awareness among health care providers.
Journal of family medicine and primary careTwo-dimensional and three-dimensional ultrasonographic diagnosis of congenital auricular anomalies.
Frontiers in medicineLong-Term Outcomes After Orbital Hypertelorism Correction: An Assessment of Objective Photogrammetric and Patient-Reported Outcomes.
The Journal of craniofacial surgeryBeyond the face: multidimensional care challenges and unmet needs in Hemifacial Microsomia families.
Frontiers in public healthTransverse Facial Cleft: An Unusual Cause of Asymmetric Crying Facies.
Indian journal of pediatricsFacial Bone Defects Associated with Lateral Facial Clefts Tessier Type 6, 7 and 8 in Syndromic Neurocristopathies: A Detailed Micro-CT Analysis on Historical Museum Specimens.
BiologyMacrostomia Surgery Using Small Z-plasty for Construction of the Corner of the Mouth.
Plastic and reconstructive surgery. Global openIdentification of functional non-coding variants associated with orofacial cleft.
Nature communicationsCommisuroplasty for Macrostomia in Tessier 7 Cleft Using Modified Vermillion Square Flap Technique.
The Journal of craniofacial surgeryLower labial vermilion myomucosal flap for commissuroplasty of Tessier 7 transverse facial cleft.
International journal of pediatric otorhinolaryngologyA Population-Based Study of Limb Body Wall Complex With Proposed Features for Prenatal Diagnosis.
American journal of medical genetics. Part AEvaluation of Orbital Asymmetry in Patients with Unilateral Cleft Lip and Palate Using Cone Beam Computed Tomography.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationAssociation between human cytomegalovirus infection and incidence of severe orofacial clefts: a series of rare cases.
BMC oral healthSubcutaneous pedicle subunit flap for upper lip reconstruction.
JPRAS openPersonal and Cultural Perceptions About Orofacial Clefts in the Democratic Republic of the Congo.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationPostoperative Bleeding After Facial Cleft Repair: A Retrospective Review of TriNetX Database.
The Journal of craniofacial surgeryEvaluating Geographic Distribution and Potential Environmental Risk Factors of Orofacial Cleft Anomalies Utilizing a Statewide Birth Defects Registry.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationChallenges in nasal reconstruction for facial clefts Tessier 3 bilateral and Tessier 0: a staged surgical approach case report.
Maxillofacial plastic and reconstructive surgeryDeep Learning-Based Assessment of Lip Symmetry for Patients With Repaired Cleft Lip.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationCleft-Related Revision Procedures: Surgeon Perspectives on Shared Decision-Making and a Decision Aid Prototype.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationFamilial Oculoauriculovertebral Spectrum: A Genomic Investigation of Autosomal Dominant Inheritance.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationMultidisciplinary Oral Rehabilitation of Complex Frontonasal Dysplasia: A Case Report.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationBenefit Finding in Craniofacial Conditions: A Qualitative Analysis of Patient and Parent Perspectives.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationMain genetic entities associated with tooth agenesis.
Clinical oral investigationsSingle Stage Management of a Severe Form of Grade 3 Hypertelorism With Sincipital and Basal Encephaloceles-Lessons Learnt!
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationCongenital teratoma of the oral cavity - the largest personal series of cases.
Oral and maxillofacial surgeryTrue Median Cleft With Sinus Tract in the Nasal Septum: A Case Report.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationThe Correlation Between Static and Dynamic Facial Asymmetry in Unilateral Cleft Lip and Palate.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationTessier 7 Cleft: Clinical Presentation and Surgical Correction in a Case Report.
CureusEpidemiological profile of patients attending the maxillofacial prosthodontics unit at Ibn Sina University Hospital in Rabat, Morocco: a cross-sectional study.
The Pan African medical journalFacial Cleft in a Newborn.
Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of IndiaReconstructive management of a patient with Tessier number 10 cleft.
Journal of surgical case reports"A Retrospective Evaluation of the Impact of Prenatal Diagnosis of Facial Clefts. Does Prenatal Diagnosis Matter?".
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association[Paramedian frontal clefts or superior orbital clefts].
Annales de chirurgie plastique et esthetiqueOptimal timing for plastic surgical procedures for common congenital anomalies: A review.
World journal of clinical pediatricsReconstruction of oblique facial cleft deformity with adjacent flap and nasolabial flap: A case report.
International journal of surgery case reportsPrenatal ultrasound diagnosis of an isolated right transverse facial cleft: A case report.
Asian journal of surgeryA novel MED12 pathogenic variant in a female fetus with facial cleft and cardiac defects identified in the first trimester.
Prenatal diagnosisThe Psychology of Patients With Oral-Facial Clefts: A Review of Victor Hugo's The Man Who Laughs ( L'homme qui rit ).
The Journal of craniofacial surgerySame-day Discharge for Cleft Palate Repair: A Single-Surgeon Retrospective Analysis.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationNovel Technique for Median Cleft Lip Comprising the Simultaneous Formation of the Columella, Philtrum, and Cupid's Bow.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationPrevalence and associated factors of congenital anomalies in Ethiopia: A systematic review and meta-analysis.
PloS oneSurgical reconstruction of the external nose: Alar rotational and hinged flap techniques for facial cleft Tessier 0-1 with lipoma on dorsal nasal region - A case report.
International journal of surgery case reportsBilateral Maxillary Duplication in Tessier No. 7 Cleft: An Uncommon Congenital Deformity with a Challenging Radiological Diagnosis.
Diagnostics (Basel, Switzerland)What We Learned from Performing the Inverse Malek Procedure to Repair Bilateral Cleft Lips and Palates: A Single-Center Retrospective Study.
Journal of clinical medicineBilateral Cleft lip Simulation.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationValidity of the Cleft Aesthetic Rating Scale Does Not Improve with Inclusion of Fixed Scores for Atypical Outcomes.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationEvaluation of a Novel Objective Method for The Assessment of Nasal Symmetry Among Patients with Unilateral Cleft Lip.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationNeglected Case of Facial Cleft Associated with Adam Complex: Soft Tissue Reconstruction with Abbe Flap and Nasal Transposition-A Case Report.
Journal of maxillofacial and oral surgeryEvaluation of Long-Term Outcomes of Transverse Facial Cleft Repair.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationRefining macrostomia correction: Case series applying square flap technique and Z/W-plasty skin closure for enhanced aesthetic and functional outcome.
International journal of surgery case reportsWhole Exome Sequencing Identifies Damaging Variants in Indonesians with Clefts.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationPregnancy with Facial Cleft: 20 Years of Experience at a Single Center.
The Israel Medical Association journal : IMAJComprehensive surgical reconstruction of Tessier number 7 congenital craniofacial cleft. A rare case report.
International journal of surgery case reportsAmniotic Band Syndrome with Severe Facial Cleft: A Case Report.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationCleft Lip and Palate Antenatal Diagnosis: A Swiss University Center Performance Analysis.
Diagnostics (Basel, Switzerland)Surgical correction of Tessier cleft no. 7: A single center 18-year experience.
Journal of plastic, reconstructive & aesthetic surgery : JPRASSonic hedgehog signaling in craniofacial development.
Differentiation; research in biological diversitySingle-stage Repair of Bilateral Cleft Lip and Bilateral Transverse Facial Cleft in Goldenhar Syndrome: A Case Report.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationIsolated Paramedian cleft of Lower LIP: A Rare Entity.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationAirway management under general anesthesia for infants and young children with the first and second branchial syndrome featuring unilateral mandibular dysplasia: A case series of 8 children.
Journal of stomatology, oral and maxillofacial surgeryDistribution and Phenotype of Goldenhar Syndrome and Its Association With Other Anomalies.
The Journal of craniofacial surgeryOur experience in one-step closure of patients with facial clefts in Surakarta: Serial cases at Dr. Moewardi Hospital.
International journal of surgery case reportsTracheoesophageal Fistula with Bilateral Facial Cleft: A Rare Occurrence.
Journal of Indian Association of Pediatric SurgeonsAccuracy of prenatal detection of facial clefts and relation between facial clefts, additional malformations and chromosomal abnormalities: a large referral-center cohort.
Archives of gynecology and obstetricsAssociation between air pollutants and birth defects in Xiamen, China.
Frontiers in pediatricsAmniotic band syndrome with CNS involvement: a pediatric neurosurgeon's dilemma-a case series and literature review.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgerySingle-Stage Posterior Vomerine Ostectomy and Primary Cheiloplasty in Patients with Bilateral Cleft Lip & Palate and Protuberant Premaxilla.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationA Proposal for the Classification of Temporomandibular Joint Disc Deformity in Hemifacial Microsomia.
Bioengineering (Basel, Switzerland)Focal Dermal Hypoplasia: Case Series.
Indian journal of dermatologyTessier 30 Facial Cleft: A Rare Craniofacial Anomaly.
International journal of clinical pediatric dentistryBilateral Tessier no. 7 cleft with an accessory maxilla and osseous choristoma: a case report.
Journal of surgical case reportsUnilateral Cleft lip and Palate: Long-Term Results of the Malek Technique.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationGoltz Syndrome Combined with Triple X Syndrome, a Case Report.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationRapid confirmation of trisomy 13 of maternal origin by QF-PCR following postmortem tissue cell culture failure in a pregnancy with trisomy 13 at amniocentesis and fetal postaxial polydactyly and facial cleft.
Taiwanese journal of obstetrics & gynecologyA Unique Appliance for Median Facial Cleft Management With Sleep Apnea due to Undeveloped Nasal Septum: A Rare Case Report.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationSurgical Correction of a Bifid Nose Deformity with a Split M-Shaped Flap.
Facial plastic surgery & aesthetic medicineTessier cranio-facial clefts presenting to a tertiary eye care center in Northern India: Ophthalmic features and a review of management.
Indian journal of ophthalmologyEvaluation of prenatal breastfeeding workshop to inform and support mother with antenatal diagnosis of cleft lip/palate.
Journal of stomatology, oral and maxillofacial surgery3D printed models in pregnancy and its utility in improving psychological constructs: a case series.
3D printing in medicineFacial cleft presenting as a congenital facial papule.
Pediatric dermatologyPrimary care in early cleft lip and palate rehabilitation: A dental perspective.
Journal of family medicine and primary carePrenatal diagnosis of ectrodactyly-ectodermal dysplasia clefting syndrome ‒ a case report with literature review.
Case reports in perinatal medicineAnalysis of the Results of Sonographic Screening Examinations According to the Maternity Guidelines Before and After the Introduction of the Extended Basic Screening (IIb Screening) in Hesse.
Ultraschall in der Medizin (Stuttgart, Germany : 1980)Tessier's Cleft Number 6 Revisited: A Series of 26 new Cases and Literature Review of 44.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationCriteria for early and late velopharyngoplasty in 61 children with cleft palate.
Journal of stomatology, oral and maxillofacial surgeryDistraction Osteogenesis in a Tessier 6 Cleft After Fronto-Orbito-Zygomatic Osteotomy - A Case Report.
Annals of maxillofacial surgeryStudies on teratogenic effect of ochratoxin A given via mouldy diet in mice in various sensitive periods of the pregnancy and the putative protection of phenylalanine.
Toxicon : official journal of the International Society on ToxinologyRetinoic Acid Deficiency Underlies the Etiology of Midfacial Defects.
Journal of dental researchBirth prevalence of orofacial cleft in a tertiary hospital in Riyadh, Saudi Arabia: A retrospective audit.
The Saudi dental journalQuality of Life After Orthognathic Surgery in Patients with Cleft: An Overview of Available Patient-Reported Outcome Measures.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationMorphological Analysis of Nose in Patients of Tessier No. 0 Cleft With a Bifid Nose in China.
Frontiers in pediatricsA Comparative Prevalence of Birth Defects between Newborns of Immigrant and Native-Born Mothers in Taiwan: Ten Years of Population-Based Data.
International journal of environmental research and public healthPresentation and surgical management of a patient with a true cleft mandible.
Journal of oral biology and craniofacial researchPAX7, PAX9 and RYK Expression in Cleft Affected Tissue.
Medicina (Kaunas, Lithuania)Prenatal Sonographic and Molecular Genetic Diagnosis of Popliteal Pterygium Syndrome.
Diagnostics (Basel, Switzerland)Paranasal transposition flap in facial soft tissue reconstruction of facial cleft Tessier type 3 & ADAM complex: A case report.
International journal of surgery case reportsFetal markers for the detection of infants with craniofacial malformation.
Seminars in fetal & neonatal medicinePrenatal diagnosis of isolated lateral facial cleft by ultrasonography and three-dimensional printing: A case report.
World journal of clinical casesManagement of Large Dural Defect with CSF Leak in Hypertelorism Correction.
Annals of maxillofacial surgeryEctomesenchymal Chondromyxoid Tumor: A Rare Association With an Asymmetrical Soft Palate Cleft.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationTarsoconjunctival-Skin Flap as Another Option in Correcting Ectropion for Oro-Ocular Cleft Reconstruction: Report of 2 Cases.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationCongenital Cheek Fistula: A Rare Case of Developmental Abnormality in the Buccal Area.
CureusTessier 30 Facial Clefts-A Literature Review of 72 Cases (1996-2020), Suggested Treatment Protocol, Outcome Measures, Minimum Dataset for Future Case Reports, and Registries.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationEffect of bilateral infraorbital nerve block on intraoperative anesthetic requirements, hemodynamics, glycemic levels, and extubation in infants undergoing cheiloplasty under general anesthesia.
Journal of dental anesthesia and pain medicinePreloaded Monoka (Lacrijet) and congenital nasolacrimal duct obstruction: Initial results.
Journal francais d'ophtalmologieAn Extended 45-year Long-term Follow-up on a 1-13 Rare Facial Cleft Patient.
The Journal of craniofacial surgery[Ultrasound scan of a fetus with facial cleft must be done from the lip to the uvula].
Gynecologie, obstetrique, fertilite & senologieA Rare Patient With Midline Facial Cleft.
The Journal of craniofacial surgeryFacial cleft? The first case of manitoba-oculo-tricho-anal syndrome with novel mutations in China: a case report.
BMC pediatricsEyeball Preservation With Purse-String Conjunctival Closure for Melting Corneal Ulcer in Rare Facial Cleft.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationObservation of the Epithelial Cell Behavior in the Nasal Septum During Primary Palate Closure in Mice.
Frontiers in physiologyMISSED DIAGNOSIS OF ISOLATED BILATERAL TRANSVERSE FACIAL CLEFT: A CASE REPORT.
Annals of Ibadan postgraduate medicineIs intraoperative supplementation of dextrose essential for infants undergoing facial cleft surgeries?
Journal of anaesthesiology, clinical pharmacologyCleft of lip and palate: A review.
Journal of family medicine and primary careSimulation Surgery Using 3D 3-layer Models for Congenital Anomaly.
Plastic and reconstructive surgery. Global openRare Facial Cleft: Surgical Treatment and Middle-Term Follow-up During Charity Operation.
Craniomaxillofacial trauma & reconstructionA systematic approach on the frequency of cleft lip/palate in pediatric patients with leukemia.
Journal of stomatology, oral and maxillofacial surgeryFamily Impact of Child Oro-Facial Cleft.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationTrue Median Cleft Lip-15 Years of Review and Prevalence.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationWolf-Hirschhorn syndrome: Prenatal diagnosis and molecular cytogenetic characterization of a de novo distal deletion of 4p (4p16.1 → pter) in a fetus with facial cleft and preaxial polydactyly.
Taiwanese journal of obstetrics & gynecologyProatlas anomalies in craniofacial malformations: 5-year experience in King Chulalongkorn Memorial Hospital.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgerySurgical management of the Tessier 7 cleft: A review and presentation of 5 cases.
JPRAS openImage-guided navigation surgery for bilateral choanal atresia with a Tessier number 3 facial cleft in an adult.
Archives of craniofacial surgeryFrontonasal dysplasia: A case report.
Archives of craniofacial surgery[Application of modified vermillion flap and orbicularoris oris bundle anastomosis in repair of transverse facial cleft].
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciencesOrbicularis oris muscle reconstruction and cheiloplasty with Z-plasty in a patient with a transverse facial cleft.
Maxillofacial plastic and reconstructive surgeryA rare case of bilateral oblique facial cleft and accessory maxilla with repaired unilateral cleft lip and palate.
National journal of maxillofacial surgeryFacial Cleft in a Mayan Figurine.
The Journal of craniofacial surgeryA Rare Case of a Combination of Tessier Cleft 0 and 3 in a 4-Year-Old Child-A Case Report.
Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of IndiaTransverse facial cleft (macrostomia) repair: Modification of a traditional technique.
Journal of plastic, reconstructive & aesthetic surgery : JPRASMosaic trisomy 22 at amniocentesis: Prenatal diagnosis and literature review.
Taiwanese journal of obstetrics & gynecologyHoloprosencephaly with Clefts: Data of 85 Patients, Treatment, and Outcome: Part 2: Management, Surgical Treatment, and Unexpected Aspects of Holoprosencephaly Cleft Patients.
Annals of maxillofacial surgeryHoloprosencephaly with Clefts: Data of 85 Patients, Treatment and Outcome: Part 1: History, Subdivisions, and Data on 85 Holoprosencephalic Cleft Patients.
Annals of maxillofacial surgerySurgical repair for transverse facial cleft: two flaps with a superiorly rotated single Z-plasty lateral to the commissure.
Journal of plastic surgery and hand surgeryBifid Tongue and Cleft Palate With and Without a Tessier 30 Facial Cleft: Cases of Rare Congenital Anomalies and a Review of Management and Literature.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationNew Technologies in Rhinoplasty: A Comprehensive Workflow for Computer-assisted Planning and Execution.
Plastic and reconstructive surgery. Global openOral and dental findings in emanuel syndrome.
International journal of paediatric dentistryTessier 30 Median Mandibular Hard and Soft Tissue Cleft, One-Stage Reconstruction Using a Template-Guided Resorbable "U"-Shaped Plate.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationCrucial and Overlapping Roles of Six1 and Six2 in Craniofacial Development.
Journal of dental researchSingle Stage Repair of #30 Facial Cleft with Bone Morphogenic Protein.
Plastic and reconstructive surgery. Global openLateral Canthal Clefts of the Eyelid.
Ophthalmic plastic and reconstructive surgeryThe location of the fetal ears: A hint for prenatal diagnosis of agnathia-otocephaly complex.
Journal of clinical ultrasound : JCUComplete bilateral Tessier's facial cleft number 5: surgical strategy for a rare case report.
Surgical and radiologic anatomy : SRAThe oculoauriculofrontonasal syndrome: Further clinical characterization and additional evidence suggesting a nontraditional mode of inheritance.
American journal of medical genetics. Part APhiltrum reconstruction in unilateral cleft lip repair.
International journal of oral and maxillofacial surgeryFgfr1 conditional-knockout in neural crest cells induces heterotopic chondrogenesis and osteogenesis in mouse frontal bones.
Medical molecular morphologyAnatomic approximation approach to correction of transverse facial clefts.
Journal of plastic, reconstructive & aesthetic surgery : JPRASApproach to Half-Nose and Proboscis Lateralis.
The Journal of craniofacial surgeryGenome-wide interaction studies identify sex-specific risk alleles for nonsyndromic orofacial clefts.
Genetic epidemiologyDiagnostic criteria in Pai syndrome: results of a case series and a literature review.
International journal of oral and maxillofacial surgeryAtypical Facial Clefts From Northcentral Nigeria, Review of 36 Cases.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationReconstruction of the oral commissure in patients with unilateral transverse facial cleft.
The British journal of oral & maxillofacial surgeryEffect of Using Ringer's Lactate, with and without Addition of Dextrose, on Intra-Operative Blood Sugar Levels in Infants Undergoing Facial Cleft Surgeries.
Anesthesia, essays and researchesThe Arkansas Tessier Number 3 Cleft Experience: Soft Tissue and Skeletal Findings With Primary Surgical Management: Four-Step Approach.
The Journal of craniofacial surgeryCould fetal reduction induce facial cleft? Report of a case.
The British journal of oral & maxillofacial surgeryEmbryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK.
CellRepairing a Facial Cleft by Polyether-Ether-Ketone Implant Combined With Titanium Mesh.
The Journal of craniofacial surgeryDouble limbal dermoid with Tessier's paramedian facial cleft.
Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and StrabismusAnatomical repair of a bilateral Tessier No. 3 cleft by midfacial advancement.
Maxillofacial plastic and reconstructive surgeryA Descriptive Study of Chlorhexidine as a Disinfectant in Cleft Palate Surgery.
Clinical medicine & researchPara commissural cleft of the lower lip: A first case described in the literature.
Journal of stomatology, oral and maxillofacial surgeryScar Management After Surgical Repair of Lateral Facial Clefts.
Journal of maxillofacial and oral surgeryCompound mutations in Bmpr1a and Tak1 synergize facial deformities via increased cell death.
Genesis (New York, N.Y. : 2000)Computer-Assisted Surgery in Facial Bipartition Surgery.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial SurgeonsEctopic Preauricular Sinus in a Facial Cleft and Microtia Patient.
Archives of craniofacial surgeryTwo-stage Corrections of Rare Facial Tessier's Cleft - 3,4,5,6,7.
Annals of maxillofacial surgeryTessier number 4 bilateral craniofacial cleft associated with amniotic band syndrome: 22 years of follow-up.
Journal of stomatology, oral and maxillofacial surgeryPrenatal diagnosis of an 8q22.2-q23.3 deletion associated with bilateral cleft lip and palate and intrauterine growth restriction on fetal ultrasound.
Taiwanese journal of obstetrics & gynecologyPrenatal diagnosis of a 1.6-Mb 4p16.3 interstitial microdeletion encompassing FGFRL1 and TACC3 associated with bilateral cleft lip and palate of Wolf-Hirschhorn syndrome facial dysmorphism and short long bones.
Taiwanese journal of obstetrics & gynecologyPhenotypic spectrum of Tessier facial cleft number 5.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial SurgeryRare craniofacial cleft in a dark-skinned African population.
Nigerian medical journal : journal of the Nigeria Medical AssociationPattern of maxillofacial surgical conditions in North Central Nigeria: A 5-year experience of an indigenous surgical mission.
Nigerian journal of clinical practicePrenatal 3D sonography of an isolated lateral facial cleft.
Journal of clinical ultrasound : JCUMllt10 knockout mouse model reveals critical role of Af10-dependent H3K79 methylation in midfacial development.
Scientific reports[Approach of the unilateral cleft lip with Meara's cheiloplasty technique].
Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia PediatricaSurgery Navigation in Treating Congenital Midfacial Dysplasia of Patients With Facial Cleft.
The Journal of craniofacial surgerySupernumerary Nostril: Two Years Follow-Up.
The Journal of craniofacial surgeryInvasive cervical resorption and the oro-facial cleft patient: a review and case series.
British dental journalManagement of a Large Frontal Encephalocoele With Supraorbital Bar Remodeling and Advancement.
The Journal of craniofacial surgeryOcular Morbidity in the Correction of Orbital Hypertelorism and Dystopia: A 15-Year Experience.
Plastic and reconstructive surgeryCleft lip and palate: Parental experiences of stigma, discrimination, and social/structural inequalities.
Annals of maxillofacial surgeryAssociações
Organizações que acompanham esta doença — pra ter apoio e orientação
Ainda não temos associações cadastradas para Fenda facial.
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Midline congenital upper lip sinus: a rare clinical case with analytical review of diagnostic and therapy strategies.
- Perioperative Care of a Four-Year-Old Child With Teebi Hypertelorism Syndrome: A Rare Craniofacial Disorder.
- Transverse facial cleft repair: Preventing pigmentation around the postoperative scar by excising the pigmented white lip at the cleft margin-A retrospective case series of Japanese patients.
- Bilateral Cheilorhinoplasty Techniques May Be Applied to an Incomplete Rare Facial Cleft: Case Report and Literature Review.
- Modiolus-Based Dynamic Reconstruction for Transverse Facial Cleft: A Retrospective Cohort Study.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:141229(Orphanet)
- MONDO:0015411(MONDO)
- GARD:19964(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
- Q5428558(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
