Hemangioblastoma

Agnostic Therapy in Rare Solid Tumors

NCT06638931

Observational Study for Assessing Treatment and Outcome of Patients With Primary Brain Tumours Using cIMPACT-NOW and 2021 WHO Classification

NCT05259605

68-Ga DOTATATE PET/MRI in the Diagnosis and Management of Somatostatin Receptor Positive CNS Tumors.

NCT04081701

Real-World Effectiveness and Pharmacogenetics of Belzutifan in VHL Syndrome: The BELIEVE-VHL Trial

NCT07167329

Propranolol and Von Hippel-Lindau Disease

NCT05424016

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Outros ensaios clínicos

19 ensaios clínicos encontrados, 7 ativos.

Distribuição por fase

NCT00005902 · Study of Brain and Spinal Cord Tumor Growth and Cyst Develop…Ativo

NCT04458935 · Retrospective Case Series of Trans-scleral Cryotherapy for R…Ativo

NCT00330564 · Evaluation of Sunitinib Malate in Patients With Von Hippel-L…Encerrado

NCT00970970 · Visualizing Vascular Endothelial Growth Factor (VEGF) Produc…Concluído

NCT02120040 · Psychosocial Consequences of the Screening of Von Hippel Lin…Concluído

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NCT00052013 · Treatment of Von Hippel-Lindau (VHL)-Related Hemangioblastom…Concluído

NCT00589784 · Phase II Trial of Sunitinib (SU011248) in Patients With Recu…Concluído

NCT01015300 · Bevacizumab (Avastin) in Unresectable/Recurrent Hemangioblas…Encerrado

EARLY_PHASE1

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Timeline de publicações

1.022 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 1.022

#1

Comparing laminectomy and unilateral hemilaminectomy in spinal hemangioblastoma resection: A multicenter study.

Brain & spine2026

This study compared laminectomy and hemilaminectomy for resection of spinal (sHBs), evaluating extent of resection, 12-month postoperative functional outcomes, perioperative complications overall, with particular attention to postoperative bleeding. This retrospective international multicenter study included 280 primary sHB patients from 13 neuro-oncological centers who underwent either laminectomy (n = 125) or hemilaminectomy (n = 155). The endpoints were the extent of resection, functional outcomes at 12 months, and postoperative bleeding requiring retreatment. Multivariable logistic regression analysis was performed to determine independent risk factors associated with these outcomes. The rate of complete resection was similar between both surgical approaches, with 86.4% in the laminectomy group and 90.3% in the hemilaminectomy group (p = 0.35). Independent predictors of incomplete resection included preoperative modified McCormick >2 (OR: 4.29, p = 0.001), combined intra- and extramedullary tumor location (OR: 2.91, p = 0.03), and cervical or thoracic tumor location (OR: 3.38, p = 0.01). Functional outcomes at 12 months did not differ significantly between the laminectomy- and hemilaminectomy-groups (p = 0.97). Postoperative bleeding was more frequently observed in tumors involving two or more spinal segments (OR: 14.6, p = 0.01). The choice of surgical approach did not impact the incidence of postoperative bleeding (p = 0.55). Laminectomy and hemilaminectomy result in comparable outcomes of sHB. Tumors affecting multiple spinal segments are associated with an increased risk of postoperative bleeding, while combined intra- and extramedullary growth, impaired preoperative functioning and non-lumbar location were associated with incomplete resection. Given the comparable outcomes, the selection of the surgical approach may be guided by surgeon preference and individual patient anatomy.

#2

Unusual immunohistochemical profiles in hemangioblastomas and their relevance in differential diagnosis: A comprehensive study of 112 cases.

Journal of neuropathology and experimental neurology2026 Feb 28

Hemangioblastomas (HB) are rare CNS neoplasms. Their main differential diagnosis includes meningioma, glioma, and metastatic clear cell renal carcinoma. However, the diagnostic immunoprofile of HBs is only imprecisely defined. We analyzed a multicentric cohort of HBs using tissue microarrays and whole sections to determine immunoreactivities of a range of selected meningothelial, glial and other markers used in diagnostic pathology. The clinical and pathological features were correlated. The cohort included 112 tumors from 104 patients (46.1% males, 53.9% females) with a mean age 50.1 years. The tumors occurred in cerebellum (72%), spine (18.9%) and medulla oblongata (5.4%). No HB expressed SSTR2A, MUC4 or STAT6. Expression of glial markers S100, GFAP, Olig2, and SOX10 was observed in 93.3%, 80.6%, 5.1%, and 8.1% of cases, respectively. Inhibin-α was positive in 84.5% and carbonic anhydrase IX (CAIX) in 100% of the cases. Negative PAX8 immunostaining was observed using specific C-terminus antibody whereas N-terminus anti-PAX8 staining yielded 63.2% positivity. T-brachyury, SATB2, and GPNMB were observed in 3.8%, 2.1%, and 20.8%, respectively. No expression of SOX17, CDX2, Sall4, GATA3, or INSM1 was observed. Thus, HBs show a consistent PAX8-negative/CAIX-positive immunoprofile while they lack meningothelial markers and occasionally may express SOX10 and Olig2.

#3

Pathological features and clinical outcomes of hemangioblastoma in the spinal cord of three dogs.

The Journal of veterinary medical science2026 Feb 13

Hemangioblastomas are rare intramedullary vascular tumors. Their biological nature is considered benign, but there is little information in dogs. This report describes histopathological and immunohistochemical features and postoperative clinical courses of three dogs to expand the current knowledge of this tumor. Histopathological examination revealed the proliferation of neoplastic stromal cells with irregularly arranged blood vessels and clusters of lymphocytes. Immunohistochemically, neoplastic stromal cells were immunolabeled for glial fibrillary acidic protein (GFAP), neuron specific antigen (NSE), and vimentin, and capillary endothelia and vessel walls were immunolabeled for CD31 and smooth muscle actin (SMA). Postoperative follow-up revealed improvements in neurological symptoms and no evidence of tumor recurrence for 3 months to 3 years, suggesting that surgical excision is a beneficial treatment method.

#4

Isolated cerebellar metastasis as the initial presentation of follicular thyroid carcinoma: A rare neurosurgical encounter.

Surgical neurology international2026

Brain metastases from follicular thyroid carcinoma (FTC) are exceptionally rare, especially in the infratentorial region. Even rarer is when such a lesion precedes the diagnosis of the primary tumor. This case highlights the importance of maintaining diagnostic vigilance for metastatic disease, even in patients with seemingly benign thyroid pathology. A 55-year-old female presented with progressive imbalance and headache. Magnetic resonance imaging revealed a solid-cystic lesion in the cerebellar vermis compressing the fourth ventricle. She had a prior diagnosis of colloid goiter based on fine-needle aspiration cytology (FNAC). Intraoperatively, the lesion mimicked a hemangioblastoma; frozen section supported this diagnosis. However, final histopathology and immunohistochemistry confirmed metastatic FTC. Subsequent positron emission tomography-computed tomography and repeat thyroid FNAC confirmed the primary tumor, leading to total thyroidectomy and radioactive iodine therapy. This case is likely the first reported instance of isolated cerebellar metastasis from FTC, masquerading as a primary central nervous system tumor. Surgeons should maintain a high index of suspicion when encountering posterior fossa tumors with atypical features, even with a prior benign thyroid FNAC.

#5

Whole-Genome Landscape of Retinal Hemangioblastomas.

Translational vision science & technology2026 Jan 05

Retinal hemangioblastomas (RHs) are rare benign vascular tumors that present mostly as manifestations of Von Hippel-Lindau (VHL) syndrome. In contrast to other VHL syndrome-associated tumors, only a handful of molecular studies have been published on RHs. It remains unclear whether VHL alterations alone drive RH tumorigenesis. Whole-genome sequencing (WGS) was performed on germline- and RHs-derived DNA of five patients. Additionally, transcriptomes of four unaffected retinas and five choroid controls were compared with those of RH biopsies. Heterozygous germline missense variants and copy number losses impacting VHL were identified. In all RH biopsies, mosaic loss of chromosome 3 was present, indicating the "second hit" in RHs is likely loss of the complete wild-type chromosome 3. Few additional somatic short nucleotide variants (SNVs) indels, or structural variants with deleterious potential were detected, suggesting that somatic changes are rare but not limited to the VHL gene region. RNA sequencing revealed reduced VHL expression in tumor tissue and downstream gene expression changes consistent with loss of VHL expression. RHs have few somatic changes. Loss of chromosome 3 is likely the second hit in RHs with germline VHL alterations. RHs are benign neoplasms with little somatic changes compared with other VHL-syndrome associated tumors. Variants affecting VHL impact downstream gene expression, variants impacting different VHL domains result in differential gene expression of these downstream targets. RNA sequencing may aid in the evaluation of variants of unknown significance.

Publicações recentes

Optic disc and peripapillary tumors.

🥉 Relato de caso

Taiwan J Ophthalmol2026 Jan-Mar

Giant Vulvar Vascular Lesion in Pregnancy: A Case Report.

Int J Womens Health2026

Trans-scleral cryotherapy in the management of retinal hemangioblastomas.

🥉 Relato de caso

Graefes Arch Clin Exp Ophthalmol2026 Apr 11

Case Report: Sellar hemangioblastoma mimicking a pituitary macroadenoma: a diagnostic and surgical pitfall.

Front Oncol2026

Intraoperative Differentiation of Pilocytic Astrocytoma and Hemangioblastoma with Indocyanine Green Video Angiography.

📖 Revisão

J Neurol Surg A Cent Eur Neurosurg2026 Apr 9

Ver todas no PubMed

📚 EuropePMC1.202 artigos no totalmostrando 198

Somatic mutational landscape in von Hippel-Lindau familial hemangioblastoma.

Molecular oncology

Comparing laminectomy and unilateral hemilaminectomy in spinal hemangioblastoma resection: A multicenter study.

Brain & spine

Peritumoral Cystic Meningioma With Diagnostic Challenges: Two Case Reports and a Literature Review.

Neuroendocrine Tumor of the Cauda Equina: A Report of a Rare Case With Histopathological and Immunohistochemical Correlation.

Virchows Archiv : an international journal of pathology

YAP1::TFE3-rearranged inflammatory spindle cell PEComa of the anterior mediastinum in a 5-year-old child: first pediatric case.

Rare Case of Multifocal Spinal Hemangioblastomas With Holocord Syringo-Hydromyelia in an Adolescent Male.

Journal of neuropathology and experimental neurology

Unusual immunohistochemical profiles in hemangioblastomas and their relevance in differential diagnosis: A comprehensive study of 112 cases.

Fatal hemangioblastoma: a case report and literature review.

Diagnosis of Von Hippel-Lindau Syndrome Via Pancreatic Cyst Fluid Next-Generation Sequencing.

ACG case reports journal

The Journal of veterinary medical science

Pathological features and clinical outcomes of hemangioblastoma in the spinal cord of three dogs.

Journal of neuro-oncology

Belzutifan-induced tumor regression in sporadic hemangioblastoma: a case report and literature review.

Isolated cerebellar metastasis as the initial presentation of follicular thyroid carcinoma: A rare neurosurgical encounter.

Ocular oncology and pathology

Retinal Capillary Hemangioblastoma: A Comprehensive Review on Treatments.

Healthcare (Basel, Switzerland)

Exploring the Illness Experience of Patients with Central Nervous System Hemangioblastomas in Von Hippel-Lindau Disease: A Qualitative Study.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica

Hemangioblastoma of the Kidney-A Comprehensive Clinical, Pathological, and Genetic Analysis of Four Cases.

Navigating the Unseen: A Rare Case of Intradural Extramedullary Spinal Hemangioblastoma and a Systematic Review of Surgical Challenges and Outcomes.

Translational vision science & technology

Whole-Genome Landscape of Retinal Hemangioblastomas.

[A rare case of adrenal hemangioblastoma and literature review].

Zhonghua nei ke za zhi

Survival Impact of Surgery, Radiation, and Socioeconomic Factors in Spinal Hemangioblastoma: A Population-Based Study.

Combination tumors of the nervous system: A single-center analysis of a rare condition and comprehensive review of the literature.

Neuro-oncology advances

Journal francais d'ophtalmologie

Complete involution of retinal hemangioblastoma with single session cryotherapy.

Cerebellar Hemangioblastoma Resection Complicated by Postoperative Vasogenic Edema in the Setting of Concurrent Immunotherapy Treatment.

Attention can shift the reference eye under binocular fusion failure: A case report.

Journal of vision

Ocular oncology and pathology

Belzutifan for Ocular Tumors in Patients with von Hippel-Lindau Disease.

Pineal region hemangioblastoma: a case report and literature review.

BMC surgery

Acta neuropathologica communications

Prognostic relevance of MIB-1 labeling index in VHL-associated and sporadic spinal hemangioblastomas: a subgroup analysis from a multicentric study.

European journal of ophthalmology

A rare case of conjunctival hibernoma in a von Hippel-Lindau (VHL) patient: Possible association?

Retinal detachment risk in a cohort of von hippel-lindau patients at a Major U.S. tertiary care facility.

AJO international

Life (Basel, Switzerland)

Familial Von Hippel-Lindau Disease: A Case Series of Cerebral Hemangioblastomas with MRI, Histopathological, and Genetic Correlations.

Intraoperative Ultrasound in the Management of Rare Lesions Involving the Intradural Extramedullary Spinal Compartment: A Quick, but Effective Helping Hand to Define the Optimal Surgical Strategy.

Virchows Archiv : an international journal of pathology

Recurrent mTOR pathway alterations in renal cell carcinoma with hemangioblastoma-like features: A multi-institutional study of 9 cases with expanding morphologic spectrum.

Primary cerebellar angiosarcoma: a rare case report and literature review.

BMC surgery

Journal of the neurological sciences

Stereotactic radiosurgery as adjuvant or salvage treatment for sporadic hemangioblastomas: A multi-center international study.

Journal of cancer research and clinical oncology

Primary hemangioblastoma of rectum: a rare case report and review of literature.

International journal of surgical pathology

Renal Cell Carcinoma With Hemangioblastoma-Like Features and Leiomyomatous Stroma: A Rare Case Report and A Potential Pathological Diagnostic Pitfall.

Journal of neuroimmunology

Iatrogenic NORSE: Immune checkpoint inhibitor-related anti-GFAP autoimmune astrocytopathy.

Autonomic Dysfunction Following Surgical Resection of Cervicomedullary Hemangioblastoma: A Case Report and Literature Review.

Clinical nuclear medicine

All-in-One Case: Comprehensive Detection of VHL Syndrome With 68 Ga-DOTATATE PET/CT.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

Ruptured Hemorrhagic Posterior Fossa Hemangioblastoma With Atypical Dissemination to Meckel's Cave.

Virchows Archiv : an international journal of pathology

Renal hemangioblastoma and renal cell carcinoma with fibromyomatous stroma and hemangioblastoma-like areas belong to the spectrum of one entity.

Case Report: von Hippel-Lindau (VHL) disease: a young female presenting with multiple organ tumors.

Frontiers in genetics

Belzutifan for patients with Von Hippel-Lindau (VHL) disease-associated heterogeneous tumors - a retrospective single center analysis.

BMC cancer

Case report: Von Hippel-Lindau syndrome with multisystem involvement: a therapeutic dilemma.

Case reports in veterinary medicine

Intramedullary Hemangioblastoma in the Cervical Spinal Cord of a Dog.

Animals : an open access journal from MDPI

Canine Hemangioblastoma: Case Series and Literature Review.

[Cerebellar hemangioblastoma presenting with positional vertigo as the initial symptom: a case report and literature review].

Zhonghua yi xue za zhi

Intraoperative neurophysiological monitoring in surgery for intramedullary spinal cord lesions - workflow, setup and outcomes.

Acta neurochirurgica

Predicting outcomes in spinal hemangioblastoma surgery: Role of post-operative neurological status.

Centripetal filling and pathological insights: a rare case of sporadic renal hemangioblastoma with literature review.

Frontiers in physiology

Gross total resection is associated with improvement and prognosis even in von Hippel-Lindau disease-related hemangioblastomas: Nationwide registry in Japan.

Neuro-oncology practice

Medical archives (Sarajevo, Bosnia and Herzegovina)

Surgical Outcomes and Prognostic Factors for Resectability of Intramedullary Spinal Cord Tumors Incorporating Intraoperative Neurophysiological Monitoring In Vietnam.

Asian journal of endoscopic surgery

Laparoscopic Left Hepatectomy for Slowly Progressing Primary Hepatic Carcinosarcoma Associated With Von Hippel-Lindau Disease.

Journal of current ophthalmology

Revealing a Heterozygous FCGR1A Variant in a Patient with Uveal Melanoma and Von Hippel-Lindau Syndrome: A Rare Case Report.

VON Hippel-Lindau syndrome: A rare case of epididymal cystadenoma associated with hemospermia.

Urology case reports

Expression of Follicle-Stimulating Hormone Receptor in Von Hippel-Lindau Associated Tumors and Cysts: An Immunohistochemical Study.

Medicina (Kaunas, Lithuania)

Outcomes of Pars Plana Vitrectomy in Complicated Retinal Detachment Secondary to Retinal Capillary Hemangioblastoma.

International ophthalmology clinics

Role of PPV in Advanced Retinal Hemangioblastoma-A Systematic Review.

Clinicopathological and molecular characterization of seven rare cases of renal cell carcinoma with hemangioblastoma-like features: Expanding the morphological spectrum of renal tumours with tuberous sclerosis complex/mammalian target of rapamycin mutations.

Histopathology

American journal of ophthalmology case reports

Spontaneous separation of epiretinal membrane associated with retinal hemangioblastoma: a case report with 10-year follow-up.

The gradual expansion of multiple intramedullary metastatic renal cell carcinoma in a patient with von Hippel-Lindau disease with multiple intramedullary hemangioblastomas: illustrative case.

Long-term Safety and Efficacy of Belzutifan in Von Hippel-Lindau Syndrome: A VHL Coordinating Care Center Experience.

PLoS computational biology

Mathematical modeling and simulation of tumor-induced angiogenesis in retinal hemangioblastoma.

Pancreatic Hemangioblastoma in a Patient with von Hippel-Lindau Disease: A Case Report.

Surgical case reports

Pancreatic Involvement by Mixed Serous Neuroendocrine Neoplasm Detected by Endosonography With Fine-Needle Tissue Acquisition in Von Hippel-Lindau Disease.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

The effect of oral belzutifan on retinal hemangioblastomas in von Hippel-Lindau syndrome.

Experimental and therapeutic medicine

Diagnosis and treatment of Von Hippel-Lindau syndrome: A case series.

Pathology, research and practice

A case series of newly described rare mesenchymal tumors of the knee and the role of molecular testing in their histopathological diagnosis.

South Dakota medicine : the journal of the South Dakota State Medical Association

Cerebellar Hemangioblastoma Masquerading as Recurrent Posterior Fossa Meningioma: A Case Report.

Hong Kong medical journal = Xianggang yi xue za zhi

Presentation, management, and clinical outcomes of von Hippel-Lindau syndrome.

Racial and socioeconomic disparities in long term survival after surgery and radiation for spinal cord hemangioblastoma.

Scientific reports

International journal of retina and vitreous

The clinical features and real world treatment outcomes in von Hippel Lindau related retinal capillary hemangioblastomas.

Medical journal, Armed Forces India

Screening for Von Hipple-Lindau gene mutation and management of cerebellar hemangioblastoma presenting as erythrocytosis.

Seminars in ophthalmology

Ruthenium-106 Plaque Brachytherapy for the Management of Intraocular Tumors in Thailand: The First Report from Southeast Asia.

Renal haemangioblastoma: a clinicopathologic and molecular characterization of 8 cases supporting the presence of recurrent MTOR pathway alterations.

Histopathology

The impact of surgery on patients with Von Hippel-Lindau-associated tumors: an international patient survey.

The oncologist

Neurologia medico-chirurgica

Real-world Experience of Embolization for Intracranial Tumors in Japan: Analysis of 2,756 Cases from Japanese Registry of NeuroEndovascular Therapy 4.

Tumor-to-Tumor Metastasis in a Patient With Hemangioblastoma Unrelated to von Hippel-Lindau Disease: A Case Report and Review of the Literature.

Detection of VHL variant on multigene panel testing for hereditary breast cancer: Implications for genetic counselling.

Cancer genetics

Retinal cases & brief reports

Unilateral Retinal Pigment Epithelium Dysgenesis (URPED): New Cases, Literature Review, and Considerations of the Similarities and Differences with Combined Hamartoma of the Retina and Retinal Pigment Epithelium (CHRRPE).

Respiratory medicine case reports

A potential new entity pending further validation of pulmonary primary interstitial Tumor: Lymphangioleiomyomatosis-like.

International ophthalmology

Clinicopathological evaluation of secondary conjunctival pigmentations following enucleation.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

Unilateral change of laryngeal adductor reflex and hiccups resolution after removal of bulbar hemangioblastoma: is there a connection?

Risk Analysis of Retinal Hemangioblastomas in Nonadvanced Stages of von Hippel-Lindau Syndrome Using Ultra-widefield Imaging: The ULTRA von Hippel-Lindau Study.

Ophthalmology science

Advancing the Landscape of Clinical Actionability in Von Hippel-Lindau Syndrome: An Evidence-Based Framework from the INT2GRATE Oncology Consortium.

Survival and Functional Outcomes Following Surgical Resection of Intramedullary Spinal Cord Tumors: A Series of 253 Patients over 22 Years.

Angiomatous, Predominantly Cystic Meningiomas: A Case Report and Literature Review of a Unique Group of Meningiomas.

Hypoxia Inducible Factor-2α (HIF-2α) Pathway Inhibitors.

Journal of neurosurgery. Spine

Are dorsal column deficits inevitable in intramedullary spine tumor resection?

Renal cell carcinoma with fibromyomatous stroma (RCC FMS) and with hemangioblastoma-like areas is part of the RCC FMS spectrum in patients with tuberous sclerosis complex.

Histopathology

Outcomes After Stereotactic Radiosurgery for Intracranial Hemangioblastoma in Von Hippel-Lindau Disease and Sporadic Cases: An International Multicenter Study.

Neurosurgery

Translational cancer research

When is belzutifan the right option for von Hippel-Lindau disease-associated hemangioblastomas?-a critical review of LITESPARK-004 results.

Leptomeningeal hemangioblastoma: illustrative case.

Genotype-phenotype correlation in Iranian retinal hemangioblastoma patients and genetic diagnosis algorithm for Von Hippel-Lindau disease.

Ophthalmic genetics

A case of recurrent hemangioblastoma receiving blood supply from the mastoid and transosseous branches of the occipital artery.

Kathmandu University medical journal (KUMJ)

Unilateral Pheochromocytoma in Von Hippel-Lindau Syndrome Revealed by a Hemangioblastoma.

Dual Inhibition of HIF-1α and HIF-2α as a Promising Treatment for VHL-Associated Hemangioblastomas: A Pilot Study Using Patient-Derived Primary Cell Cultures.

Biomedicines

Unmasking a Hemangioblastoma: A Case of Obstructive Hydrocephalus in a 43-Year-Old Male Patient.

Spinal Hemangioblastoma: The Role of Imaging Characteristics in Preoperative Diagnosis and Surgical Planning.

Fibroblast growth factor receptor expression in hemangioblastomas: A novel therapeutic target.

PloS one

Fatal intracranial haemorrhage shortly after belzutifan initiation in von Hippel-Lindau (VHL) disease-associated haemangioblastoma.

ESMO open

Diagnostic Challenges and Insights in Optic Nerve Hemangioblastoma using Magnetic Resonance Imaging: A Case Report.

Current medical imaging

Journal of neurological surgery. Part A, Central European neurosurgery

Rapid Clinical Deterioration of a Patient with a Posterior Fossa Hemangioblastoma and Extensive Cerebellar Ischemia: Report of a Unique Case.

Neurological Outcome of Spinal Hemangioblastomas: An International Observational Multicenter Study About 35 Surgical Cases.

Journal of endocrinological investigation

Pediatric and adolescent von Hippel-Lindau disease: tumor profiles, genotype-phenotype correlation and comparison with adults.

Magnetic resonance imaging clinics of North America

Intramedullary Spinal Cord Tumors and Tumor-Like Lesions.

Retina (Philadelphia, Pa.)

Macular Neovascularization Related to Retinal Hemangioblastoma.

Belzutifan for von Hippel-Lindau disease-associated renal cell carcinoma and other neoplasms (LITESPARK-004): 50 months follow-up from a single-arm, phase 2 study.

The Lancet. Oncology

Taiwan journal of ophthalmology

Retinal vascular proliferation with fibrotic regression in von Hippel-Lindau disease.

Genotype-specific neoplastic risk profiles in patients with VHL disease.

Endocrine-related cancer

Advances in anatomic pathology

Hemangioblastoma-like Clear Cell Stromal Tumor of the Lung: A Comprehensive Review With Insights From a Case.

Anlotinib for the treatment of recurrent and refractory hemangioblastomas: a case report and review of literature.

Factors that predict progression of von Hippel-Lindau disease-related malignancy: a longitudinal cohort study.

BMC cancer

Journal of medical genetics

Very early-onset symptomatic CNS haemangioblastoma in Von Hippel-Lindau disease.

Operative neurosurgery (Hagerstown, Md.)

Resection of a Cervical Spine Hemangioblastoma in Von Hippel-Lindau Disease: 2-Dimensional Operative Video.

Journal of Korean Neurosurgical Society

Von Hippel-Lindau Disease : A Comprehensive Review of Diagnosis, Genetics, Clinical Challenges, and Surveillance.

Stereotactic radiosurgery in the management of central nervous system hemangioblastomas: a systematic review and meta-analysis.

Neurosurgical review

Surgical treatment of rare peripheral nerve lesions: long-term outcomes and quality of life.

Diagnosis of shunt nephritis through cerebrospinal fluid culture: avoiding the need for kidney biopsy. Illustrative case.

"Incidentally" discovered Von Hippel Lindau disease: an emerging clinical phenotype.

The oncologist

Novel Case of Bilateral Adrenal Tumors Confirms Pathogenicity of Previously Described c.463+4C>G Variant in the von-Hippel Lindau Gene.

Molecular biology reports

Von Hippel-Lindau syndrome: clinical features, genetic foundations, and management strategies.

Journal of current ophthalmology

Unveiling a TGFBI Variant in the Retinal Capillary Hemangioblastoma, Type II Granular Corneal Dystrophy, and Von Hippel-Lindau Families: Unlocking Potential for Early Intervention and Targeted Therapy.

Case reports in ophthalmology

Novel Von Hippel-Lindau Germline Variants in Iranian Patients with Retinal Capillary Hemangioblastoma.

Local tumor control and neurological outcomes after surgery for spinal hemangioblastomas in sporadic and von Hippel-Lindau disease: A multicenter study.

Neuro-oncology

Journal francais d'ophtalmologie

[Retinal vasoproliferative tumor (retinal reactive astrocytic tumor)].

Clinical journal of oncology nursing

A New Era of Management of Von Hippel-Lindau Disease-Associated Tumors With Belzutifan.

Klinische Monatsblatter fur Augenheilkunde

Morphology of Retinal Hemangioblastoma in von Hippel-Lindau Disease Revealed by Optical Coherence Tomography Angiography.

Surgical pathology clinics

Renal Neoplasia: Rare Subtypes and Uncommon Clinical Presentations.

Relationship between ZHX2 Expression and VHL Gene Alteration in VHL-associated and Sporadic Hemangioblastomas of the Central Nervous System.

Long-term surgical outcomes and prognosis of cervical spinal hemangioblastomas.

Letter to editor "Intraoperative indocyanine green (ICG) videoangiography in spinal hemangioblastoma surgery - helpful tool or unnecessary?" by Jan-Helge Klinger et al. [1].

International journal of surgery case reports

Retinal capillary hemangioma in a pthisical globe: Late sequelae in a case of Von Hippel-Lindau (VHL) disease presenting with endophthalmitis.

Applied immunohistochemistry & molecular morphology : AIMM

Immunohistochemical Expression of PAX8 in Central Nervous System Hemangioblastomas: A Potential Diagnostic Pitfall for Neuropathologists.

Pathology, research and practice

Clinicopathological features and molecular genetic changes of primary renal hemangioblastoma, a TSC-associated tumor.

Journal of vitreoretinal diseases

Belzutifan as the Primary Treatment of Bilateral Juxtapapillary Retinal Hemangioblastoma in a Patient With Von Hippel-Lindau Disease.

Endoscopic Keyhole Approach Is Useful in the Diagnosis and Removal of Cystic Cerebellar Hemangioblastoma: A Case Report.

NMC case report journal

Is the TriNetX Database a Good Tool for Investigation of Real-World Management of Von Hippel-Lindau?

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko

[Stereotactic radiotherapy of spinal hemangioblastoma].

Lung clear cell mesenchymal tumor with a hemangioblastoma-like morphology: A systematic review.

Asian journal of surgery

Glioma located on the right cerebellar hemisphere misdiagnosed as hemangioblastoma: A case report.

Asian journal of surgery

Intraoperative indocyanine green (ICG) videoangiography in spinal hemangioblastoma surgery - helpful tool or unnecessary?

Integrated surgical intervention for intradural extramedullary hemangioblastoma of the cervical spine: a case report and literature review.

Operative neurosurgery (Hagerstown, Md.)

Microsurgical Resection of a Vermian Hemangioblastoma Using the Occipital Interhemispheric Transtentorial Approach: 2-Dimensional Operative Video.

Von Hippel-Lindau disease with ocular and multiple systemic findings.

BMJ case reports

Neuroimaging clinics of North America

Pediatric Spinal Vascular Abnormalities: Overview, Diagnosis, and Management.

Spine Stereotactic Radiosurgery Provides Long-Term Local Control and Overall Survival for Benign Intradural Tumors.

Neurosurgery

Spinal cord hemangioblastomas in von Hippel-Lindau disease.

Neuro-oncology advances

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Comparative analysis of stereotactic radiosurgery outcomes for supratentorial hemangioblastomas in von hippel-lindau disease and sporadic cases: A multi-center international study.

Pediatric patients with von Hippel-Lindau and hemangioblastomas treated successfully with belzutifan.

Pediatric blood & cancer

Genotype-phenotype correlation of ocular von Hippel-Lindau disease in Koreans.

PloS one

Unique properties of clinical manifestation and magnetic resonance imaging for differential diagnosis of optic nerve hemangioblastoma.

Eye (London, England)

The American journal of tropical medicine and hygiene

Concurrence of Neurocysticercosis and Hemangioblastoma.

Application of carbonic anhydrase IX in sporadic hemangioblastoma of the central nervous system and hemangioblastoma associated with von Hippel-Lindau disease.

Clinical neuropathology

Phenotypic and Genotypic Features of a Chinese Cohort with Retinal Hemangioblastoma.

Genes

A nonsecreting suprasellar ectopic pituitary adenoma: A case report.

Radiology case reports

Molecular and clinical oncology

Clinical characteristics and surgical strategy of sporadic cerebellar hemangioblastomas.

Belzutifan for patients with von Hippel-Lindau disease-associated CNS haemangioblastomas (LITESPARK-004): a multicentre, single-arm, phase 2 study.

The Lancet. Oncology

Japanese journal of radiology

Cranial and spinal computed tomography (CT) angiography with photon-counting detector CT: comparison with angiographic and operative findings.

JPMA. The Journal of the Pakistan Medical Association

Consensus guidelines for the management of posterior fossa tumour for low- and middle-income countries.

Dual manifestations: spinal and cerebellar hemangioblastomas indicative of von Hippel-Lindau syndrome.

Radiology case reports

Ocular oncology and pathology

Belzutifan in Individuals with von Hippel-Lindau Retinal Hemangioblastomas: Institutional Experience and Review of the Literature.

Understanding Adult Central Nervous System Hemangioblastomas: A Systematic Review.

Ophthalmic surgery, lasers & imaging retina

Significant Improvement in Retinal Capillary Hemangioblastoma With Belzutifan.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Innovative solutions? Belzutifan therapy for hemangioblastomas in Von Hippel-Lindau disease: A systematic review and single-arm meta-analysis.

Spontaneous massive intraventricular hemorrhage due to hemangioblastoma in a child.

Asian journal of surgery

Neurosurgical Implications of Targeting Hypoxia-Inducible Factor 2α in Hemangioblastomas with Belzutifan.

Indian journal of ophthalmology

Role of optical coherence tomography angiography in retinal tumors: A narrative review.

Trigeminal nerve hemangioblastoma in the setting of undiagnosed von Hippel-Lindau disease: illustrative case.

Current oncology (Toronto, Ont.)

Radiosurgically Treated Recurrent Cerebellar Hemangioblastoma: A Case Report and Literature Review.

Optic nerve and chiasm hemangioblastomas in von Hippel-Lindau disease: report of 12 cases and review of the literature.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

Belzutifan as the first-line treatment for a challenging von Hippel-Lindau-related retinal hemangioblastoma: successful treatment of a case and review of the literature.

Pediatric intramedullary spinal cord tumors: A national cancer database analysis of demographics, patterns of care, and survival.

Late-Onset Manifestations of Von Hippel-Lindau Syndrome: A Case Report.

Cystic intracranial solitary fibrous tumor: a case report.

Translational vision science & technology

Optical Coherence Tomography Angiography-Navigated Laser Photocoagulation of Retinal Hemangioblastomas in Patients With von Hippel-Lindau Disease.

Cauda equina myxopapillary ependymoma in von Hippel-Lindau disease: A case report.

Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de Citologia

Characterization of spinal hemangioblastomas in patients with and without von Hippel-Lindau, and YAP expression.

Incidence and Survival of Patients With Malignant Primary Spinal Cord Tumors: A Population-Based Analysis.

Neurospine

Operative neurosurgery (Hagerstown, Md.)

Technical Considerations for the Surgical Management of a C2 Spinal Cord Hemangioblastoma and Subjacent Cervical Spondylotic Myelopathy: A 2-Dimensional Operative Video.

Comprehensive treatment of von Hippel-Lindau disease: A case report.

Cancer innovation

AJNR. American journal of neuroradiology

Arterial Spin-Labeling Perfusion Lightbulb Sign: An Imaging Biomarker of Pediatric Posterior Fossa Hemangioblastoma.

An Unusual Case of Pheochromocytoma Associated with von Hippel-Lindau Disease and Lynch Syndrome During Pregnancy.

JCEM case reports

Cerebellar Hemangioblastoma Mimicking Arteriovenous Malformation: A Case Report.

Oral Hypoxia-Inducible Factor 2α Inhibitor Belzutifan in Ocular von Hippel-Lindau Disease: Subgroup Analysis of the Single-Arm Phase 2 LITESPARK-004 Study.

Ophthalmology

Somatostatin receptor 2A expression in von Hippel-Lindau-related hemangioblastomas.

Cancer

Early surgical treatment of retinal haemangioblastomas: 10-year follow-up.

Acta ophthalmologica

Archives of endocrinology and metabolism

Expression of somatostatin receptors in hemangioblastomas associated with von Hippel-Lindau disease as a novel diagnostic, therapeutic, and follow-up opportunity: A case report and literature review.

Journal of orthopaedic case reports

Case Report of a Hemangioblastoma Originating from the T1 Spinal Nerve Treated with in Toto Resection, Hemicorporectomy and Pedicle Screw Stabilization.

Preoperative embolization and microsurgical resection of a cerebellar hemangioblastoma: embolization goals and technical nuances of the approaches. Illustrative case.

Brain tumor research and treatment

Patients With Hemangioblastoma: Mood Disorders and Sleep Quality.

Multimodal management of giant solid hemangioblastomas in two patients with preoperative embolization.

Journal of neuroendovascular therapy

Differences and Advantages of Particles versus Liquid Material for Preoperative Intracranial Tumor Embolization: A Retrospective Multicenter Study.

Applied immunohistochemistry & molecular morphology : AIMM

A Cerebellar Tumor-to-Tumor Metastasis in a Patient With Von Hippel-Lindau Disease.

Diagnostic Role of Oral Fluorescein Angiography in Pediatric Ambulatory Clinics.

Ophthalmology. Retina

Pre-operative Embolization of a Cerebellar Hemangioblastoma Using Polyvinyl Alcohol (PVA) and Target Tetra 360 Detachable Coil.

Journal of Korean Neurosurgical Society

Prognostic Factors of Spinal Intramedullary Hemangioblastoma : Analysis of Surgical Outcomes and Tumor Characteristics.

Journal of neuro-oncology

Screening and surveillance recommendations for central nervous system hemangioblastomas in pediatric patients with Von Hippel-Lindau disease.

Longitudinal Pulse-Synchronous Bouncing During Catheter Angiography-A Phenomenon Specific to Spinal Hemangioblastomas.

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Próxima:Doenças relacionadas

Doenças relacionadas

Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico

Ordenadas pelo número de sintomas em comum.

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6 em comum

ORPHA:2495

Tumor das meninges

6 em comum

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Doença de von Hippel-Lindau

6 em comum

ORPHA:892

Cisto da aracnoide

5 em comum

ORPHA:2356

Defeito do tubo neural

5 em comum

ORPHA:3388

Craniofaringioma

5 em comum

ORPHA:54595

Encefalite infecciosa

Doença do metabolismo do folato

ORPHA:98252

ORPHA:285657

Glioma

Adrenoleucodistrofia ligada ao X

ORPHA:182067

ORPHA:43

Malformação capilar

Deficiência de hormônio pituitário adquirida

ORPHA:211247