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ORPHA:548CID-10 · A30.0CID-11 · 1B20ENDÊMICA NO BRASIL
Esta condição está no Orphanet, mas não é rara no Brasil. BR é 2º país do mundo em casos (~17k novos/ano OMS); notificação compulsória. Fonte: PRC4-2017.
Esta doença tem causa genética. Recomendamos procurar um médico geneticista para diagnóstico, exames genéticos e aconselhamento familiar.
neuroInício todas idadesHerança Complex
Também conhecida comoDoença de HansenMorfeiaHanseníase

Hanseníase é uma doença infecciosa crônica que afeta principalmente a pele e o sistema nervoso periférico.

Última verificação: Fonte: sem afirmação sobre o SUS a verificarEm construçãohistóricoSugerir correção
Mantido por Agente Raras·Colaborar como especialista →

Introdução

O que você precisa saber de cara

💬
EM LINGUAGEM SIMPLES

A hanseníase, também chamada de doença de Hansen, é um distúrbio conhecido desde a antiguidade. É causada por bactérias chamadas Mycobacterium leprae e é contagiosa, o que significa que pode ser transmitida de pessoa para pessoa. Geralmente é contraída ao respirar gotículas aéreas dos tosses e espirros de indivíduos afetados, ou ao entrar em contato com seus fluidos nasais. No entanto, não é altamente transmissível, e aproximadamente 95 % das pessoas que são expostas ao Mycobacterium leprae nunca desenvolvem hanseníase. A infecção pode ser contraída em qualquer idade, e os sinais e sintomas podem levar de vários meses a até 20 anos para aparecer.

A hanseníase afeta a pele e os nervos periféricos, que conectam o cérebro e a medula espinhal aos músculos e às células sensoriais que detectam sensações como toque, dor e calor. A maioria das pessoas com a condição apresenta áreas de dano cutâneo (lesões cutâneas) e problemas de função nervosa (neuropatia periférica); porém, a gravidade e a extensão dos problemas variam amplamente. A hanseníase ocorre em um espectro, no qual a forma mais grave é chamada multibacilar ou lepromatosa, e a forma menos grave é chamada paucibacilar ou tuberculóide. Padrões de sinais e sintomas intermediários entre essas formas são às vezes chamados de formas limítrofes.

A hanseníase multibacilar geralmente envolve um grande número de lesões cutâneas, incluindo tanto danos superficiais quanto nódulos sob a pele. Os tecidos úmidos que revestem as aberturas do corpo, como as pálpebras e o interior do nariz e da boca (membranas mucosas), também podem ser afetados, o que pode levar à perda de visão, destruição do tecido nasal ou fala comprometida. Algumas pessoas com a condição apresentam dano a órgãos e tecidos internos. O dano nervoso que ocorre na hanseníase multibacilar frequentemente resulta em falta de sensação nas mãos e nos pés. Lesões repetidas que passam despercebidas e não são tratadas por causa dessa falta de sensação podem levar à reabsorção dos dedos das mãos ou dos pés pelo corpo, resultando no encurtamento ou perda desses dígitos.

A hanseníase paucibacilar tipicamente envolve um pequeno número de lesões superficiais na pele. Geralmente há perda de sensação nessas áreas, mas os outros sinais e sintomas que ocorrem na hanseníase multibacilar são menos prováveis de se desenvolver nesta forma do distúrbio.

Em qualquer forma de hanseníase, podem ocorrer episódios chamados reações, que podem levar a danos nervosos adicionais. Esses episódios podem incluir reações de reversão, que envolvem dor e inchaço das lesões cutâneas e dos nervos nas mãos e nos pés. Pessoas com as formas mais graves de hanseníase podem desenvolver um tipo de reação chamado eritema nodoso leprótico (ENL). Esses episódios envolvem febre e nódulos cutâneos dolorosos. Além disso, podem ocorrer nervos doloridos e inchados. O ENL também pode levar à inflamação das articulações, dos olhos e dos testículos nos homens.

A hanseníase tem sido historicamente estigmatizada por sua natureza infecciosa e pelas deformidades que pode causar. Esse estigma pode gerar problemas sociais e emocionais para as pessoas com a condição. No entanto, tratamentos modernos podem impedir que a hanseníase piore e se espalhe para outras pessoas. Embora a infecção seja curável, os danos nervosos e teciduais que ocorreram antes do tratamento são geralmente permanentes.

Fonte: MedlinePlus Genetics (NLM/NIH), traduzido
📋
Informacoes curadas por IA — podem conter imprecisoes

Hanseníase é uma doença infecciosa crônica que afeta principalmente a pele e o sistema nervoso periférico.

Pesquisas ativas
10 ensaios
51 total registrados no ClinicalTrials.gov
Publicações científicas
24.359 artigos
Último publicado: 2026
Medicamentos
2 com registro
Dapsone (DAPSONE), Dapsone 100 mg (DAPSONE TABLETS)

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✓ 2 medicamentos específicos desta doença (registro ANVISA, FDA ou SUS/CEAF)
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DAPSONE (DAPSONE)DAPSONE 100 MG (DAPSONE TABLETS)

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
Unknown
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Worldwide
Início
All ages
🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: A30.0
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Entender a doença

Do básico ao detalhe, leia no seu ritmo

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Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

👁️
Olhos
7 sintomas
🧬
Pele e cabelo
5 sintomas
🧠
Neurológico
4 sintomas
💪
Músculos
3 sintomas
😀
Face
3 sintomas
🦴
Ossos e articulações
2 sintomas

+ 19 sintomas em outras categorias

Características mais comuns

90%prev.
Neuropatia periférica
Muito frequente (99-80%)
55%prev.
Neuropatia por aprisionamento
Frequente (79-30%)
55%prev.
Fisiologia anormal do sistema nervoso autônomo
Frequente (79-30%)
55%prev.
Episódios agudos de sintomas neuropáticos
Frequente (79-30%)
55%prev.
Nódulo cutâneo
Frequente (79-30%)
55%prev.
Nervo periférico aumentado
Frequente (79-30%)
48sintomas
Muito frequente (1)
Frequente (15)
Ocasional (20)
Muito raro (11)
Sem dados (1)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 48 características clínicas mais associadas, ordenadas por frequência.

Neuropatia periféricaPeripheral neuropathy
Muito frequente (99-80%)90%
Neuropatia por aprisionamentoEntrapment neuropathy
Frequente (79-30%)55%
Fisiologia anormal do sistema nervoso autônomoAbnormal autonomic nervous system physiology
Frequente (79-30%)55%
Episódios agudos de sintomas neuropáticosAcute episodes of neuropathic symptoms
Frequente (79-30%)55%
Nódulo cutâneoSkin nodule
Frequente (79-30%)55%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico24.359PubMed
Últimos 10 anos200publicações
Pico2026170 papers
Linha do tempo
2026Hoje · 2026🧪 1989Primeiro ensaio clínico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
✓Aprovado4
3Fase 34
2Fase 29
1Fase 16
·Pré-clínico28
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 51 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Lepra

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

Onde estão os ensaios

Com ensaio aberto em 8 países. O ponto verde marca onde há vaga agora.

🟢 Recrutando agora

6 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

Outros ensaios clínicos

51 ensaios clínicos encontrados, 10 ativos.

Distribuição por fase
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NCT00669643 · Uniform Multidrug Therapy Regimen for Leprosy PatientsConcluído
PHASE4🇧🇷 Brasil
NCT01006759 · Prevention of Disability: Proposal for a Guidance Manual for…Concluído
PHASE1🇧🇷 Brasil
NCT00860717 · The Use of Low Level Laser Therapy for Wound Healing in Lepr…Concluído
NA🇧🇷 Brasil
NCT06416033 · Serum Irisin Level In Leprosy PatientsConcluído
🇪🇬 Egito
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NCT05091216 · The Effects of Traditional Chinese Medicine Mouthwash Soluti…Concluído
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NCT05047809 · The Effect of "Jinchuang Ointment" (JCO) on the Treatment of…Concluído
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NCT04944498 · Modified Tarsorrhaphy vs Gold Weight Implant for Paralytic L…Concluído
NAIndonesia
NCT03662022 · Post ExpOsure Prophylaxis for LEprosy in the Comoros and Mad…Concluído
PHASE3Comoros · Madagascar
NCT05777213 · Potential Injection of Human Umbilical Cord Secretome in the…Concluído
PHASE1Indonesia
NCT03683745 · Integrated Mapping of Skin-presenting Neglected Tropical Dis…Concluído
Liberia
NCT07806357 · Prednisolone Monotherapy Versus Prednisolone Plus Methotrexa…Concluído
PHASE1Bangladesh
NCT03302897 · Phase 1 LEP-F1 + GLA-SE Vaccine Trial in Healthy Adult Volun…Concluído
PHASE1🇺🇸 Estados Unidos
NCT03526718 · Improved Understanding of Ongoing Transmission of Leprosy in…Concluído
Comoros
NCT02484469 · Impact of the Virtual Human Project on Team-based Learning: …Concluído
NA
NCT00919451 · Ciclosporin in the Management of Steroid Resistant Type 1 Re…Concluído
PHASE2Ethiopia
NCT01290744 · Effect of Additional Clofazimine on Erythema Nodosum Leprosu…Concluído
PHASE4Philippines
NCT00919815 · Ciclosporin in the Management of New Type 1 Reactions in Lep…Concluído
PHASE2, PHASE3Ethiopia
NCT00919776 · Ciclosporin in the Management of Chronic or Recurrent Erythe…Concluído
PHASE2Ethiopia
NCT00919542 · Ciclosporin in the Management of New Erythema Nodosum Lepros…Concluído
PHASE2Ethiopia
NCT01165840 · Effect of Weight and/or Obesity on Dapsone Drug Concentratio…Concluído
PHASE4🇺🇸 Estados Unidos
NCT00315809 · Molecular Epidemiology of Leprosy - PhilippinesConcluído
Philippines
NCT00138437 · Molecular and Immunological Tools for Detection of Strain Di…Concluído
🇨🇴 Colômbia
NCT02085317 · Microcirculatory Impairment in Patients With LeprosyConcluído
NA
NCT00128193 · Leprosy Skin Test Antigens TrialConcluído
PHASE2Nepal · 🇺🇸 Estados Unidos
NCT01920750 · Leprosy Skin Test Antigens Phase 1Concluído
PHASE1
NCT06627257 · Trial LEP-F1 + GLA-SE in Healthy Adult in Areas Endemic for …UNKNOWN
PHASE1🇧🇷 Brasil
NCT03947437 · Phase 1b/2a Trial to Evaluate LEP-F1 + GLA-SE in Healthy Adu…UNKNOWN
PHASE1, PHASE2🇧🇷 Brasil
NCT03324035 · Treatment of Neuropathic Pain in LeprosyUNKNOWN
PHASE3🇧🇷 Brasil
NCT03072004 · Low Level Laser Therapy Effects in Peripheral Nerves Patient…UNKNOWN
NA🇧🇷 Brasil
NCT06683690 · TGF β 1 Expression Related Gene PolymorphismUNKNOWN
🇪🇬 Egito
NCT05031091 · Epidemiology of Leprosy in French GuianaUNKNOWN
French Guiana
NCT03807362 · CC-11050 Trial in Nepalese Patients With Erythema Nodosum Le…UNKNOWN
PHASE2Nepal
NCT02550080 · Clinical Utility Of Genetic Screening For HLA-B*1301, On Sus…UNKNOWN
PHASE4🇨🇳 China
NCT00406861 · Montelukast in ENL ReactionUNKNOWN
NABangladesh
NCT03084614 · CD8 Reactivity to Microorganisms in Blood and Breast MilkEncerrado
🇺🇸 Estados Unidos
NCT01751503 · Extramembranous and Interosseous Technique of Tibialis Poste…Encerrado
NA🇬🇧 Reino Unido
NCT01885611 · Virgin Coconut Oil Oral Supplementation for Leprosy PatientsCancelado
PHASE1, PHASE2Philippines
NCT00852345 · Treatment Protocol for Clofazamine in the Long Term Treatmen…NO_LONGER_AVAILABLE
🇺🇸 Estados Unidos
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

🥉Melhor nível de evidência: Relato de caso
Timeline de publicações
4.702 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 4.702

#1

Descriptions of the natural history of erythema nodosum leprosum to inform clinical classification - A semi-systematic review.

PLoS neglected tropical diseases2026 Mar 23

Este artigo revela que as classificações temporais do Eritema Nodoso Hansênico (ENH), uma complicação dolorosa da hanseníase, são usadas de forma inconsistente na literatura médica. As definições de ENH "recorrente" e "crônico" frequentemente se sobrepõem, causando confusão. Para pacientes e médicos, essa falta de padronização dificulta o diagnóstico preciso, a comparação de tratamentos e o desenvolvimento de diretrizes clínicas claras para um manejo mais eficaz da doença.

🇧🇷 traduzido
#2

Comparative analysis of diagnostic efficacy of loop-mediated isothermal amplification (LAMP) and CBNAAT in children with suspected tubercular meningitis: a cross-sectional study.

BMJ paediatrics open2026 Mar 18

Diagnosticar meningite tuberculosa (TBM) em crianças é um desafio, e este estudo comparou dois testes, CBNAAT e LAMP, para melhorar essa detecção. O teste LAMP mostrou-se mais sensível (detecta mais casos) que o CBNAAT, embora com menor especificidade (pode ter mais falsos positivos). Para médicos, o LAMP é uma alternativa rápida e sensível, especialmente útil em locais com poucos recursos, mas a menor especificidade exige cautela na interpretação dos resultados.

🇧🇷 traduzido
#3

Outcomes of alternative therapy in HLA-B* 13:01 positive leprosy patients without dapsone versus standard MDT in negative patients: A comparative effectiveness study.

PLoS neglected tropical diseases2026 Mar 17

Para pacientes com hanseníase multibacilar que são HLA-B*13:01 positivos, e, portanto, têm alto risco de reações alérgicas graves à dapsona, este estudo comparou tratamentos alternativos sem dapsona com a terapia padrão. Os resultados mostraram que esses regimes alternativos são tão eficazes quanto a terapia padrão na cura, controle bacteriano e prevenção de recaídas e deficiências, além de possuírem segurança comparável. Isso significa que médicos e pacientes agora têm uma opção de tratamento viável e igualmente eficaz para evitar os riscos da dapsona nesses indivíduos.

🇧🇷 traduzido
#4

External quality assessment for yaws elimination in low- and middle-income countries using plasmid-based proficiency test items.

PLoS neglected tropical diseases2026 Mar 13

É importante notar que o artigo científico que você forneceu não é sobre Lepra (Hanseníase), mas sim sobre a *Bouba (Yaws)* e outras infecções. O artigo descreve o desenvolvimento de um programa de avaliação externa de qualidade (EQA) para assegurar a precisão dos testes de diagnóstico molecular da bouba em países de baixa e média renda. Para pacientes e médicos, isso significa maior confiança nos resultados dos exames, permitindo diagnósticos mais seguros e tratamentos eficazes para a bouba e outras infecções relacionadas, o que é crucial para o sucesso das campanhas de erradicação da doença. Este programa serve como um modelo funcional para garantir a qualidade diagnóstica em ambientes com poucos recursos.

🇧🇷 traduzido
#5

Determinants of small vulnerable newborn births in two rural community-based cohorts in India: a prospective study.

The Lancet regional health. Southeast Asia2026 Apr

Este estudo revelou que quase metade (48,3%) dos nascimentos em duas comunidades rurais da Índia são de Recém-Nascidos Pequenos e Vulneráveis (SVN), uma categoria que inclui bebês prematuros, com baixo peso ou pequenos para a idade gestacional. Fatores de risco significativos para SVN incluem hemorragia antes do parto, baixa estatura materna (<145 cm), histórico de bebê com baixo peso anterior, ser uma mãe de primeira viagem (nulípara) e o uso exclusivo de combustível de biomassa para cozinhar. Esses achados destacam a necessidade urgente de intervenções pré-natais direcionadas e específicas para cada região, a fim de mitigar esses riscos e melhorar a saúde de mães e bebês.

🇧🇷 traduzido

Publicações recentes

Ver todas no PubMed

📚 EuropePMC18.844 artigos no totalmostrando 191

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Understanding where people with tuberculosis seek care to serve them better.

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Descriptions of the natural history of erythema nodosum leprosum to inform clinical classification - A semi-systematic review.

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P-Phenylenediamine-Induced Angioedema-like Facies: A Case Report and Review of Pathomechanisms.

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Comparative analysis of diagnostic efficacy of loop-mediated isothermal amplification (LAMP) and CBNAAT in children with suspected tubercular meningitis: a cross-sectional study.

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Burden of Disability, Poverty, and Unmet Needs Among Persons Affected by Hansen's Disease: Insights from Antulya Nagar, Pune- A Cross-Sectional Study.

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A Study of Cutaneous Manifestations in Patients During the Post-COVID Period in A Tertiary Care Center.

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Development and Validation of a Questionnaire to Assess Social Perspectives Among Leprosy-Affected Individuals in a Rehabilitation Colony in Pune, Maharashtra, India.

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Evaluation of Serum Levels of IL-17 and IL-22 in Leprosy: A Case-Control Study.

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Outcomes of alternative therapy in HLA-B* 13:01 positive leprosy patients without dapsone versus standard MDT in negative patients: A comparative effectiveness study.

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External quality assessment for yaws elimination in low- and middle-income countries using plasmid-based proficiency test items.

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A Comparative Study of Oral Tofacitinib and Oral Methotrexate in the Treatment of Patients With Moderate to Severe Chronic Plaque Psoriasis.

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British Red Squirrels (S. vulgaris) With Leprosy Develop Skeletal Lesions.

Interdisciplinary perspectives on infectious diseases
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Optimizing a Conventional Multiplex PCR for Simultaneous Detection of Granulomatous Skin Infection Agents: Leishmania aethiopica, Mycobacterium leprae, and Mycobacterium tuberculosis.

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Emerging antimicrobial resistance among Cutibacterium acnes isolated from inflammatory acne vulgaris patients.

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Spatial and temporal distribution of neglected tropical diseases: overlap analysis, Piauí, 2013-2022.

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Ultraviolet-induced fluorescence dermoscopy in the diagnosis of scabies: The "ball sign".

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Overlooked signs and symptoms: Why leprosy is often misdiagnosed.

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Stigma associated with leprosy among patients, contacts, and the general population in an endemic region of Brazil.

Anais brasileiros de dermatologia
2026

Diagnostic Role of Loop-Mediated Isothermal Amplification (LAMP) Assay in Nasal Swabs and Slit Skin Smear Specimens in Pediatric Leprosy: Authors' Reply.

Indian journal of pediatrics
2026

Pattern of treatment outcome and safety of prednisolone in the treatment of leprosy reactions among leprosy patients in ALERT hospital: a retrospective cohort study.

BMC infectious diseases
2026

"Is disease a crime?": Exploring the possibilities of health humanities in Bhasi's Aswamedham.

Indian journal of medical ethics
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Determinants of small vulnerable newborn births in two rural community-based cohorts in India: a prospective study.

The Lancet regional health. Southeast Asia
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Gut microbiota and sarcoidosis: a concise review.

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Increasing detection of individuals with tuberculosis through engagement of informal health care providers in Northeastern Nigeria.

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Topical Corticosteroid-induced Central Serous Retinopathy: A Vision Lost and Regained.

Indian dermatology online journal
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Diagnostic Challenges of Lepromatous Leprosy in a Non-Endemic Setting: A Case of Atypical Primary Hyperpigmentation.

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The hidden burden of disease in Brazil: A quantitative comparison between official notifications and modeled estimates from the Global Burden of Disease study.

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A Case of Lepromatous Leprosy: Role of Additional Special Stains in Diagnosis.

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Tuberculosis control in Ethiopian prisons: A forgotten front in the end TB Strategy.

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Pure neural leprosy in a child: case report and diagnostic challenges.

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Type 2 Lepra Reaction Following Antituberculosis Treatment Initiation in an Elderly Male With Coexisting Hansen's Disease: A Case Report.

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Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society
2026

Quality of life in Indian people affected by leprosy? A systematic review from the country with the highest burden of leprosy cases.

Transactions of the Royal Society of Tropical Medicine and Hygiene
2026

A Rare Case of Leprosy in Sweden Mimicking Drug Eruption.

Acta dermato-venereologica
2026

Demyelinating Leprosy Neuropathy: An Unusual and Misleading Electrophysiological Pattern.

Muscle &amp; nerve
2026

Understanding healing: A comparative analysis in chronic diseases with leprosy-A scoping review.

PLoS neglected tropical diseases
2026

Infantile Digital Fibroma.

Journal of cutaneous medicine and surgery
2026

A Study Assessing Patch Test Results in Hand and Foot Eczema Patients at a Tertiary Care Hospital.

The Nigerian postgraduate medical journal
2026

The Unfolding of Familial CARD14- Associated Papulosquamous Eruption (CAPE) and a Brief Review.

Indian dermatology online journal
2026

Therapeutic Effectiveness of Narrowband-Ultraviolet B Phototherapy in Uremic Pruritus Patients with Chronic Kidney Disease Undergoing Hemodialysis - A Prospective Study.

Indian dermatology online journal
2026

Casting light on TB: a community awareness, screening, testing, and treatment campaign.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
2026

Differentiated service delivery for TB treatment.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
2026

Human LFA-1 governs T cell immune surveillance of the skin.

Science immunology
2026

Rapid Identification of Drug-Resistant Strains of Mycobacterium leprae through qPCR High-Resolution Melt Analysis (HRMA): A High-Throughput and Effective Screening Method.

Indian dermatology online journal
2026

Dermoscopy of paederus dermatitis: Evolving patterns in a tropical irritant dermatosis.

Tropical doctor
2026

Atypical cutaneous manifestations of leprosy in a non-endemic country: a case report.

Travel medicine and infectious disease
2026

Unveiling Lepromatous Leprosy in a Non-endemic Region: A Case of Delayed Diagnosis and Effective ROM (Rifampin, Ofloxacin, and Minocycline) Therapy.

Cureus
2026

Measuring Progress of 2030 Skin-Related Neglected Tropical Diseases Sustainable Development Goals.

JAMA dermatology
2026

Clinico-Epidemiological and Molecular Evidences for Reactivation of Herpesviruses in Dapsone-Induced Hypersensitivity Reactions in Nepalese Leprosy Patients: An Observational Study.

Immunity, inflammation and disease
2026

The need for materiovigilance in leprosy-treating hospitals in India: a critical perspective on patient safety.

Expert review of medical devices
2026

The cascade of care for latent tuberculosis infection in Malaysia: a cohort analysis.

BMC infectious diseases
2026

Family History and Solar Insolation in Bipolar I Disorder.

Acta psychiatrica Scandinavica
2026

Characterization of Rheumatic Manifestations in Hansen's Disease: A Standardized Approach among Patients from Puerto Rico.

The American journal of tropical medicine and hygiene
2026

When Mites Glow: Ultraviolet Dermoscopic Clues to Demodicosis.

QJM : monthly journal of the Association of Physicians
2026

Detection of Anti-Mycobacterium leprae Antibodies in Leprosy Contacts Using a Label-Free Approach with the Heat-Transfer Method.

ACS sensors
2026

Effect of Single Perineural Injection of Platelet Rich Plasma on Nerve Function in Hansen's Disease With Truncal Neuropathy: An Interventional Study.

Cureus
2026

Hyperactivation of sympathetic nerves fuels basophil infiltration in atopic dermatitis.

Immunity
2026

Cytokine polarized natural killer T cells modulate effector T cell function in leprosy.

Cytokine
2026

A Rare Presentation of Congenital Melanocytic Nevus on the Tongue and Lower Lip Mucosa.

Annals of African medicine
2026

Drug-resistant tuberculosis in war and complex emergencies: jeopardising progress towards TB elimination and antimicrobial resistance control - a scoping review and perspective.

BMJ global health
2026

Two pathogens, one disease: Rethinking leprosy diversification through ancient and modern genomes.

Clinical and translational medicine
2026

Porokeratotic Eccrine Ostial and Dermal Duct Nevus: Utility of Ultraviolet-Induced Fluorescence Dermoscopy Findings in a Rare Presentation.

Indian dermatology online journal
2026

The Predictive Role of Biomarkers for Leprosy Prophylaxis in Contacts of Patients Who Are Indices of the Disease: A Systematic Review of the Literature.

Mediators of inflammation
2026

Malassezia isolated from patients with PV exhibits resistance features supporting its pathogenic nature.

Archives of microbiology
2026

Atypical cutaneous manifestations: When leprosy and syphilis overlap.

Revista da Sociedade Brasileira de Medicina Tropical
2026

Brazil accounts for nearly 90% of the leprosy cases in the Americas.

Revista da Sociedade Brasileira de Medicina Tropical
2026

Breakthrough Tuberculosis in a Large Cohort of People Living With HIV on Preventive Treatment.

Tropical medicine &amp; international health : TM &amp; IH
2026

Presumed Very Late Relapse of Lepromatous Leprosy 35 Years After Treatment: A Diagnostic Challenge in a Non-endemic Setting.

Cureus
2026

Exploring the health-seeking journeys of individuals affected by leprosy: Lived experiences in selected urban rehabilitation centers in Ethiopia.

PLoS neglected tropical diseases
2026

Effectiveness of community-based and community-led interventions to improve the psychosocial well-being of those affected by skin-NTDs: A systematic review.

PLoS neglected tropical diseases
2026

Addressing multimorbidity in Leprosy: A retrospective chart review from India.

PLoS neglected tropical diseases
2026

Protocol of a comparative multicentric non inferiority clinical trial of WHO MBMDT with a new monthly chemotherapy regimen containing rifampicin, moxifloxacin and clarithromycin (RMC) on multibacillary patients from India.

Trials
2026

Diagnostic Role of Loop-Mediated Isothermal Amplification (LAMP) Assay in Nasal Swabs and Slit Skin Smear Specimens in Pediatric Leprosy: Correspondence.

Indian journal of pediatrics
2026

A case study of delayed-diagnosed leprosy: advancing diagnosis through MetaPath.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
2026

Persistent and Emerging High-Risk Clusters of Leprosy Detection in Brazil: A Nationwide Spatiotemporal Analysis, 2001-2023.

Tropical medicine &amp; international health : TM &amp; IH
2026

The Changing Trends in the Incidence and Clinical Presentation of Immunobullous Disorders Before and During the COVID-19 Era in a Tertiary Healthcare Centre in Andhra Pradesh.

Cureus
2026

Multibacillary Leprosy - a diagnostic and therapeutic challenge.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
2026

4-Desmethyl 7-Prenyl Mollicellin Analogue Isolated from Chaetomium brasiliense.

Chemical &amp; pharmaceutical bulletin
2026

B vitamins in dermatology.

Clinics in dermatology
2026

Engagement strategies for people living with leprosy: a scoping review of studies published from 1992 to 2024.

Archives of public health = Archives belges de sante publique
2026

Establishing a robust preclinical model to investigate early and late radiation-induced skin reactions.

Scientific reports
2026

A case report: Cutaneous leishmaniasis mimicking leprosy in an immunocompetent young adult: A diagnostic and therapeutic challenge in the Old World.

JAAD case reports
2026

Novel Combination Therapy with Sorafenib and Propranolol for Refractory Lymphangioma Circumscriptum.

Indian dermatology online journal
2026

Clinico-Dermoscopic Report of Jellyfish Dermatitis ( Lobonemoides Robustus )-Two Cases in the Same Family.

Indian dermatology online journal
2026

Recurrent pyoderma gangrenosum-like ulcers in a child revealing leukocyte adhesion deficiency type I.

Clinical and experimental dermatology
2025

Relational ontologies of AI and the technoethics of social isolation in psychosis.

PLOS mental health
2025

"The general public will never truly know what it feels like": Exploring the Lived Experiences of Persons Affected by Leprosy in Sindh, Pakistan - A qualitative study.

PLOS mental health
2025

Mental health and stigma in persons affected by Hansen's disease and their families in rural Sitapur, India.

PLOS mental health
2025

Sharing is healing: The power of storytelling to transform mental health in the field of neglected tropical diseases.

PLOS mental health
2025

Peace of mind: A quasi-experimental, mixed-method evaluation of a community-based mental health intervention for persons affected by Neglected Tropical Diseases.

PLOS mental health
2025

Quality of life among leprosy patients: An analysis of associated factors.

PLOS mental health
2026

Nodular and abscessed pinna in lepromatous leprosy with Type 2 lepra reaction.

IDCases
2026

Environmental-demographic determinants associated with tuberculosis prevalence in seven African countries: an aggregated dataset analysis.

EClinicalMedicine
2025

Barriers to effective foot care: A mixed-methods assessment among persons with leprosy-related foot disabilities living in a leprosy colony in Bankura, West Bengal.

Indian journal of dermatology, venereology and leprology
2025

Mucous membrane pemphigoid of the larynx: A rare threat to vocal and airway integrity.

Indian journal of dermatology, venereology and leprology
2025

Sustainable dermatology: Perspectives and attitudes of dermatology residents and dermatologists in India.

Indian journal of dermatology, venereology and leprology
2025

Gliptin-induced dyshidrosiform bullous pemphigoid: A rare occurrence.

Indian journal of dermatology, venereology and leprology
2026

Elegy on the death of a pemphigus patient.

Indian journal of dermatology, venereology and leprology
2025

Lichen planus follicularis tumidus of the scalp: A rare histopathological diagnosis.

Indian journal of dermatology, venereology and leprology
2026

Clinically suspected granulomatous skin lesions on the face: A prospective clinico-pathological correlation study of 77 cases.

Indian journal of dermatology, venereology and leprology
2026

Patterns and factors affecting self-medication practices among patients with dermatophytosis in South India - A case control study.

Indian journal of dermatology, venereology and leprology
2026

Feeder nerve in a facial patch of leprosy.

Indian journal of dermatology, venereology and leprology
2025

Standardising the diagnosis and management of atopic dermatitis in India: A consensus statement by the modified Delphi method by IADVL Special Interest Group of Pediatric Dermatology (STAND AD).

Indian journal of dermatology, venereology and leprology
2025

Sterile pustules in dermatology.

Indian journal of dermatology, venereology and leprology
2026

Leprosy-tuberculosis co-infection: A case series.

Indian journal of dermatology, venereology and leprology
2026

Ethical Considerations in Diagnostic Image-Based Mobile Health Applications.

Journal of the American Academy of Dermatology
2026

Pellagra-Fine arts and literature: A short journey from Pietro Belloti and Johann Wolfgang Goethe to John Wesley Caroll and Amedeo John Engel Terzi.

Clinics in dermatology
2026

Cutaneous tuberculosis: Epidemiology, pathogenesis, clinical features and investigations.

The National medical journal of India
2026

Cytokine storm in severe bacterial infections: A Mini-Review of molecular insights and treatment strategies.

Molecular biology reports
2026

Nanocarrier based topical gel of clofazimine: advanced therapeutic strategy for the treatment of leprosy.

Journal of drug targeting
2026

Serum Brain-derived Neurotrophic Factor, Stress Levels, and Quality of Life Among Leprosy Patients: A Cross-sectional Study.

Acta dermato-venereologica
2025

Global disease and economic burden of main mycobacterial infections in the working-age population from 1990 to 2021 with a forecast to 2045.

Infectious medicine
2026

Molecular Identification and Evaluation of Resistance to Antifungal Drugs in Candida Species Isolated From Diaper Rash of Neonates.

Health science reports
2026

Retained Foreign Bodies in the Facial Region: A Report of Two Cases.

Clinical case reports
2026

From Needle to Necrosis: A Case Report on Nicolau Syndrome.

Cureus
2025

Nanohydroxyapatite and Bioactive Glass Composites in Bone Regeneration: A Systematic Review.

Cureus
2026

Herpes Zoster Infection Culminating in Abdominal Motor Paresis: A Case Report.

Cureus
2026

Erythema Gyratum Repens Without an Associated Neoplasm: A Rheumatoid Twist.

Cureus
2026

Between stigma, misinformation and delay of diagnosis: healthcare worker's perspectives on leprosy care in Sindh, Pakistan.

BMC infectious diseases
2026

Integrated action for skin NTDs: Deconstructing transmission, addressing knowledge gaps, and championing one health strategies.

Nature communications
2026

Fluctuating Annual New Leprosy Case Detection and Suboptimal Contact Tracing in Tiruvallur District, Tamil Nadu, India, 2017-2022: A Cross-sectional Study.

Indian journal of public health
2026

Molecular modelling assisted identification of novel Benzoxazole derivatives as hit molecules targeting Mycobacterial Membrane Protein Large 3 (MmpL3).

Computers in biology and medicine
2025

Prevalence and risk factors for drug-induced cutaneous reactions among hospitalised patients: A retrospective study.

Bioinformation
2025

Correlation between autoimmune thyroid disease and vitiligo: An analytical study.

Bioinformation
2026

Rapid detection of Mycobacterium leprae RLEP by recombinase polymerase amplification: A pilot study.

Japanese journal of infectious diseases
2026

The Limberg rhomboid flap: History, creator, and importance in plastic surgery.

Clinics in dermatology
2026

Indoleamine 2,3-Dioxygenase: A Potential Biomarker for Neural Damage Severity of Leprosy Neuropathy.

Cellular and molecular neurobiology
2026

[Physical disability due to leprosy in the state of Bahia, Brazil (2001-2023): occurrence, change from diagnosis to discharge, and associated factors].

Cadernos de saude publica
2025

Sporadic Diffuse Palmoplantar Keratoderma in a Pediatric Patient With Early Onset: A Case Report.

Cureus
2026

Hidden in Plain Sight: The Enduring Challenge of Neglected Tropical Diseases in Khartoum State, Sudan.

Journal of tropical medicine
2025

Multi-disciplinary diagnosis and management of verrucous venous malformation of the right knee: a case report.

Frontiers in radiology
2026

Host- and pathogen-related determinants of pulmonary versus extrapulmonary tuberculosis.

European respiratory review : an official journal of the European Respiratory Society
2026

Comparative Analysis of Oral and Oropharyngeal Mucosal Lesions of American Tegumentary Leishmaniasis and Other Infectious Granulomatous Diseases and Squamous Cell Carcinoma.

Pathogens (Basel, Switzerland)
2026

Whole-Genome Sequence Analysis of Shiga Toxin-Producing Escherichia coli Isolated from Livestock Animals in Ghana.

Microorganisms
2026

Human and livestock exposure to Rift Valley fever virus and Coxiella burnetii in Eastern Ethiopia: a One Health cross-sectional study.

Tropical medicine and health
2026

Routine active case finding in Nigerian penitentiary institutions: comparing yields from digital X-ray with CAD4TB and WHO 4-symptom screening.

BMC infectious diseases
2026

Relationship between social participation and stigma in people affected by leprosy: A cross-sectional study in northeastern Brazil.

Belitung nursing journal
2026

Hypergranulotic Dyscornification - Alba Variant.

Indian journal of dermatology
2026

A Comparative Study on the Measurement Properties (Criterion Validity, Informativity, and Floor and Ceiling Effects) of Dermatology Life Quality Index (DLQI) and Skindex-29.

Indian journal of dermatology
2025

A Mortise of Immune Cells: Leprosy with Disseminated Dermatophytosis.

Journal of global infectious diseases
2026

Autoantibodies and vitamin D in leprosy patients in the Brazilian Amazon.

BMC infectious diseases
2026

Systematic review on the epidemiology, diagnostics and management of leishmaniasis recidivans.

Travel medicine and infectious disease
2026

The Changing Face of Dermatophytosis: from common skin disease to emerging resistant epidemic.

Clinical and experimental dermatology
2026

Structure-based and machine learning-assisted identification of natural phytochemicals targeting Mycobacterium leprae InhA for anti-mycobacterial therapeutics.

Folia microbiologica
2025

Unveiling the Antimicrobial Potential of Ricinus communis: A Comprehensive Review of Its Relevance to Surgical Site Infection (SSI) Pathogens.

Cureus
2025

Merciful Malady: Renbök Phenomenon Between Alopecia Areata and Psoriasis Vulgaris.

Cureus
2026

The P2X7 Receptor and Its Relation to Neglected Tropical Diseases: Focusing on Chagas Disease.

Journal of tropical medicine
2026

World Leprosy Day 2026: reflections on leprosy surveillance in Europe.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
2026

Biosensor-Based Platforms for the Detection and Screening of Mycobacterium leprae Infection.

ACS infectious diseases
2025

Lichen Scrofulosorum Without Mantoux Positivity in a 72-Year-Old Male: A Clinical Paradox.

Cureus
2026

Elevated type I interferon signature in patients with chronic granulomatous disease.

Clinical and experimental immunology
2026

Success rates of DR-TB patients and associated factors in Tanzania: a six-year cohort study.

BMC infectious diseases
2026

A rare occurrence of lepra Type II reaction in pure neuritic leprosy: a case report.

BMC infectious diseases
2026

Integrative Image Processing Framework for Enhanced Detection of Leprosy-Associated Chronic Wounds.

The international journal of lower extremity wounds
2026

A Multiepitope Protein Based on Selected Synthetic Peptides Enables Effective Serological Screening of Exposure to Mycobacterium leprae.

ACS omega
2026

Determinants of subclinical leprosy among household contacts in Indonesia: serological and socio-demographic factors.

PeerJ
2026

A multimodal neuroimaging approach evaluation of emotional response and anxiety symptoms in leprosy patients.

Transactions of the Royal Society of Tropical Medicine and Hygiene
2026

Repurposing Itraconazole in Clinical Dermato-oncology Beyond Conventional Antifungal Use- A review.

Clinical and experimental dermatology
2026

Identification of leprosy reactions using Fourier transform infrared (FTIR) spectroscopy supervised by clinical evaluation.

Journal of pharmaceutical and biomedical analysis
2026

Identifying missed opportunities in tuberculosis preventive treatment care cascade: Analysis of programme data from Maharashtra, India.

PLOS global public health
2025

Pragmatic recommendations to improve access to rehabilitation robots, assistive technologies and neurorehabilitation services in Africa: proceedings from ICORR-SASNET Ghana neurorehabilitation workshop, 2024.

Frontiers in stroke
2026

Ancient DNA study provides clues to leprosy susceptibility in medieval Europe.

Genome biology
2026

Sociodemographic Profile of Leprosy Cases in Northeastern Brazil from 2019 to 2023.

Anais da Academia Brasileira de Ciencias
2025

Effectiveness of Slit Skin Smear Versus Fite-Faraco Staining on Histopathology as a Method of Diagnosis in Leprosy - a Retrospective Hospital-Based Study.

Maedica
2026

Corticosteroids as adjunctive therapy in patients with acute/subacute paracoccidioidomycosis presenting a severe paradoxical inflammatory reaction: Two case reports and literature review.

The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
2026

Sexual and reproductive health challenges among street adolescents in Sylhet city, Bangladesh: A cross-sectional study.

PloS one
2026

Coexistence of Scrofuloderma and Lepromatous Leprosy in Reaction: A Case Report.

Clinical case reports
2026

Diagnostic utility of serum procalcitonin for early identification of bacterial sepsis in febrile dermatology inpatients: A cohort study of 118 cases.

Journal of the American Academy of Dermatology
2025

Erythema Nodosum Leprosum Triggered by Herpes Simplex Infection: A Case Report.

Cureus
2026

Elastophagocytosis in borderline tuberculoid leprosy: A rare case with diagnostic challenge and histopathological enigma: A case report.

SAGE open medical case reports
2026

Cutaneous manifestations of infectious diseases as reflected by printed funeral sermons of the 16th to 18th centuries.

Clinics in dermatology
2026

Pulex irritans: Historic repellents, insecticides, and flea traps from the 16th to the 19th century.

Clinics in dermatology
2026

Resistance to anti-leprosy drugs in multi-bacillary leprosy patients: The need for transformative action.

Indian journal of dermatology, venereology and leprology
Ver todos os 18.844 no EuropePMC

Associações

Organizações que acompanham esta doença — pra ter apoio e orientação

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Doença com base genética

Um médico geneticista pode ajudar no diagnóstico de Lepra e no aconselhamento genético da família.

Vai consultar um especialista? Confirme o registro dele no conselho.
Conselhos e sociedades

Doenças relacionadas

Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico

Perguntas frequentes

O que as famílias mais perguntam sobre esta doença — cada resposta com a fonte de onde saiu

Respostas geradas por IA a partir das fontes citadas

A condição é causada pela bactéria *Mycobacterium leprae* e pode passar de pessoa para pessoa através de gotículas de tosse ou secreções do nariz. No entanto, ela não é altamente transmissível, e a grande maioria da população exposta tem imunidade e não adoece.

Referências

Fontes citadas no texto, publicações do grafo e bases de dados usadas neste verbete

10 publicações do grafo RarasNet (PubMed) · 6 bases de dados. Títulos, periódicos e PMIDs vêm direto da fonte, sem intermediação de IA.

  1. ORPHA:548
    Orphanet
  2. GARD:6886
    GARD (NIH)
  3. Q36956
    Wikidata

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Citar este verbete

Raras. (s.d.). Lepra. Em Raras — Enciclopédia de Doenças Raras do Brasil. https://raras.org/doenca/lepra

Formato APA. Conteúdo sob CC BY 4.0 — reuso livre com atribuição.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Lepra
Compêndio · Raras BR

Lepra

ORPHA:548 · MONDO:0005124
Prevalência
Unknown
Herança
Multigenic/multifactorial
CID-10
A30.0 · Hanseníase [lepra] indeterminada
CID-11
Ensaios
10 ativos
Início
All ages
Prevalência
0.0 (Worldwide)
MedGen
UMLS
C0023343
Repurposing
4 candidatos
acedapsone — GK0582 inhibitor
clofazimine — bacterial antifolate
dapsone — DNA directed RNA polymerase inhibitor
+1 outros
Wikidata
Wikipedia
Papers 10a
Evidência
🥉 Relato de caso

📋 Origem dos dados

Esta página agrega dados de fontes públicas e oficiais. Dados sobre cobertura no SUS (PCDT, CEAF) são verificados ativamente por agente proativo (ver badge no infobox). Demais dados têm atribuição de fonte + data da última sincronização — clique para abrir o original.

Doença rara (ontologia)
fonte: Orphanet
Identificador unificado
fonte: MONDO
Indexação biomédica
fonte: MeSH (NLM)
Dado público estruturado
fonte: Wikidata
Medicamentos aprovados FDA
fonte: FDA OpenFDA
Rara