Raras
Buscar doenças, sintomas, genes...
Lesão traumática da medula espinhal
ORPHA:90058CID-10 · T09.3CID-11 · ND51.2DOENÇA RARA

Lesões na medula espinhal, com ou sem perfuração, causadas por forças externas violentas (por exemplo, ferimentos por arma de fogo; lesões de chicote; etc.).

Mantido por Agente Raras·Colaborar como especialista →

Introdução

O que você precisa saber de cara

📋

Lesões na medula espinhal, com ou sem perfuração, causadas por forças externas violentas (por exemplo, ferimentos por arma de fogo; lesões de chicote; etc.).

Pesquisas ativas
36 ensaios
2075 total registrados no ClinicalTrials.gov
Publicações científicas
51.191 artigos
Último publicado: 2026
Medicamentos
6 registrados
BACLOFEN, PREGABALIN, DANTROLENE SODIUM

Tem tratamento?

6 medicamentos registrados
Ver detalhes, fases e interações →
BACLOFENPREGABALINDANTROLENE SODIUMMIDODRINESOMATROPINDALFAMPRIDINE

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
1-5 / 10 000
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
32.0
Europe
Início
All ages
🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: T09.3
Você se identifica com essa condição?
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Entender a doença

Do básico ao detalhe, leia no seu ritmo

Preparando trilha educativa...

Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🧠
Neurológico
2 sintomas
🫘
Rins
2 sintomas
🦴
Ossos e articulações
1 sintomas

+ 10 sintomas em outras categorias

Características mais comuns

90%prev.
Lesão da medula espinhal
Muito frequente (99-80%)
55%prev.
Fraqueza devido à disfunção do neurônio motor superior
Frequente (79-30%)
55%prev.
Fisiologia anormal do sistema nervoso autônomo
Frequente (79-30%)
55%prev.
Espasticidade
Frequente (79-30%)
55%prev.
Disfunção somatossensorial
Frequente (79-30%)
55%prev.
Cefaleia
Frequente (79-30%)
15sintomas
Muito frequente (1)
Frequente (6)
Ocasional (8)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 15 características clínicas mais associadas, ordenadas por frequência.

Lesão da medula espinhalSpinal cord lesion
Muito frequente (99-80%)90%
Fraqueza devido à disfunção do neurônio motor superiorWeakness due to upper motor neuron dysfunction
Frequente (79-30%)55%
Fisiologia anormal do sistema nervoso autônomoAbnormal autonomic nervous system physiology
Frequente (79-30%)55%
EspasticidadeSpasticity
Frequente (79-30%)55%
Disfunção somatossensorialSomatic sensory dysfunction
Frequente (79-30%)55%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico51.191PubMed
Últimos 10 anos200publicações
Pico2026195 papers
Linha do tempo
2026Hoje · 2026🧪 1986Primeiro ensaio clínico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
Aprovado4
3Fase 34
1Fase 11
·Pré-clínico17
Medicamentos catalogadosEnsaios clínicos· 6 medicamentos · 20 ensaios
✓ Aprovados — podem ser usados hoje
BACLOFENPREGABALINDANTROLENE SODIUM
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Lesão traumática da medula espinhal

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

🟢 Recrutando agora

20 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

NCT07541612 · NIRS MONITORING OF SPINAL CORD ISCHEMIA IN AORTIC SURGERYRecrutando
NCT07103993 · Food Intake and Thermogenesis in High Spinal Cord InjuryRecrutando
NA
NCT07234903 · ARC-IM Therapy To Support and Promote Recovery of Ambulatory…Recrutando
NA
NCT07467187 · Invasive Home Ventilation in DenmarkRecrutando
NCT06003686 · Spinal Cord Injury Model Systems (SCIMS) - Education ModuleRecrutando
NA
NCT05776030 · Multi-speed Ergonomic WheelchairRecrutando
NA
NCT07536386 · Self-balancing Personal Exoskeleton for SCI (WIP)Recrutando
NA
NCT05954845 · The Enteric Nervous System in Spinal Cord Injury: Study of t…Recrutando
NA
NCT06559618 · Bacteriophage Therapy in Spinal Cord Injury Patients With Ba…Recrutando
PHASE1
NCT07519928 · Exploring the Feasibility and Benefits of Implementing Pelvi…Recrutando
NA
NCT07357428 · Connect-One: Early Feasibility Study of Connexus® Brain-Comp…Recrutando
NA
NCT06295146 · Virtual Peer Coaching in Manual Wheelchair SkillsRecrutando
NA
NCT04350359 · Transcutaneous Tibial Nerve Stimulation for Spinal Cord Inju…Recrutando
NA
NCT06596369 · Transcutaneous Spinal Cord Stimulation for Upper Extremity F…Recrutando
PHASE2, PHASE3
NCT07090473 · Safety of Transcutaneous Electrical Stimulation Potentiating…Recrutando
NA
NCT06706284 · Glycemic and Weight Loss Effects of GLP-1R Agonist Therapy i…Recrutando
PHASE4
NCT07521930 · Interfacing With NeuroTechnology to Expand Neural Throughput…Recrutando
NA
NCT06225245 · Augmenting Rehabilitation Outcomes and Functional Neuroplast…Recrutando
NA
NCT03026816 · Epidural Stimulation After Neurologic DamageRecrutando
NA
NCT07429305 · Combined Tibial Nerve Stimulation and Standing for People Wi…Recrutando
NA

Outros ensaios clínicos

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Publicações mais relevantes

Timeline de publicações
28.272 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 28.272

#1

Ddx20, DEAD-box helicase 20 is essential for maintaining microglial homeostasis.

Experimental neurology2026 Mar 19

Este estudo identifica que uma proteína, a Ddx20, é essencial para manter a saúde e o funcionamento adequado das micróglias, as células de defesa do cérebro e da medula espinhal. A ausência de Ddx20 compromete seriamente a capacidade dessas células de proteger e reparar o sistema nervoso, com efeitos mais graves após lesões na medula espinhal e com o envelhecimento. Essa descoberta aponta para o Ddx20 como um potencial novo alvo para desenvolver futuras terapias que melhorem a recuperação e o manejo de pacientes com lesão medular.

🇧🇷 traduzido
#2

Repurposing Dexmedetomidine: Early Pharmacological Hypothermia Enhances Neuroprotection and Improves Locomotor and Bladder Functional Recovery After SCI.

The Journal of neuroscience : the official journal of the Society for Neuroscience2026 Mar 20

Este estudo sugere que a dexmedetomidina, um medicamento já aprovado pela FDA, pode induzir uma hipotermia farmacológica rápida e sustentada após uma lesão medular (LM). Em modelos animais, esta abordagem, que combina hipotermia com neuroproteção intrínseca, demonstrou ser superior ao resfriamento convencional, promovendo uma recuperação significativamente maior das funções locomotora e vesical. Isso a torna uma estratégia terapêutica promissora, imediatamente aplicável clinicamente e sem a necessidade de equipamentos complexos para pacientes com LM aguda.

🇧🇷 traduzido
#3

Central and peripheral neuroplasticity in cervical spinal cord injury following intensive upper limb motor training: a randomised controlled trial protocol.

BMJ open2026 Mar 18

Este estudo clínico randomizado (RCT) investiga se um treinamento intensivo e adicional dos membros superiores pode melhorar a recuperação neurofisiológica e funcional em pacientes com lesão medular cervical subaguda. O objetivo é comparar seis horas extras de treino motor semanal, focado em objetivos, com o cuidado padrão, visando otimizar a função dos braços e determinar a "dose" mais eficaz de treinamento para a recuperação. Isso é crucial para pacientes, pois busca melhores resultados funcionais, e para médicos, para otimizar protocolos de reabilitação.

🇧🇷 traduzido
#4

Exosome-Loaded Engineered circBDNF Promotes Spinal Cord Injury Repair Through the PI3K/AKT/mTOR Signaling Axis.

CNS neuroscience &amp; therapeutics2026 Mar

Este estudo inovador desenvolveu uma estratégia para tratar lesões na medula espinhal (LME) utilizando exossomos que entregam uma versão modificada do fator neurotrófico BDNF (circBDNF), superando a barreira hematoencefálica. Em modelos experimentais, essa abordagem demonstrou melhorar significativamente a recuperação da função motora e a coordenação, além de promover a regeneração de nervos e reduzir danos como inflamação e morte celular na área lesionada. Tal avanço oferece uma promissora e relevante via terapêutica para pacientes com LME, justificando futuras pesquisas clínicas.

🇧🇷 traduzido
#5

Liproxstatin-1 improves functional recovery after acute spinal cord injury by inhibiting ferroptosis-induced inflammation.

Molecular and cellular neurosciences2026 Mar 17

Para pacientes e médicos, este estudo revela que o tratamento com Liproxstatin-1 após uma lesão medular aguda (LMA) em ratos melhora significativamente a recuperação funcional, como a função motora e o equilíbrio. Ele age inibindo a ferroptose, um tipo de morte celular dependente de ferro, e a inflamação que ela induz, resultando na redução da perda de tecido e de neurônios. Esses achados são promissores, indicando que a ferroptose é um alvo terapêutico inovador para neuroproteção e melhores desfechos em pacientes com LMA.

🇧🇷 traduzido

Publicações recentes

Ver todas no PubMed

📚 EuropePMC32.037 artigos no totalmostrando 196

2026

Spinal Cord Perfusion Pressure Monitoring after Traumatic Spinal Cord Injury: Indications, Techniques, and Future Horizons.

Journal of neurotrauma
2026

Exosome Cargo Molecules and NLRP3/BDNF: Clinical and Preclinical Evidence for Acupuncture-Mediated Spinal Cord Injury Recovery.

International journal of general medicine
2026

Cystometry Is Associated With Reduced Overall Mortality in Veterans With Suprasacral Spinal Cord Injury or Disease.

Neurourology and urodynamics
2026

Inhibiting glucocorticoid receptors enhances adult spinal cord neural stem cell activity and improves outcomes in spinal cord injury.

Communications biology
2026

Development of the PedsADAPSS: A Measure of Disability Appraisals in Youth with Spinal Cord Injury.

Archives of physical medicine and rehabilitation
2026

Intrathecal baclofen pump complications in adults: rates, risk factors, and spinal cord injury insights from a longitudinal cohort study.

Journal of neurosurgery. Spine
2026

The posterior approach for removal of all thoracic disc herniations: a single-surgeon experience using the partial transpedicular approach with ultrasonic bone aspiration and ultrasound guidance in 108 consecutive patients.

Journal of neurosurgery. Spine
2026

Posttraumatic syrinx resulting in syringomyelia and syringobulbia: illustrative case.

Journal of neurosurgery. Case lessons
2026

20-Deoxyingenol alleviates ferroptosis by activating transcription factor EB in spinal cord injury.

Neuroreport
2026

Mortality following surgical management of traumatic sub-axial cervical spine injuries in a South African tertiary centre.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
2026

Andorra as a living lab? The inSCI example.

Journal of rehabilitation medicine
2026

Prolonged Repetitive Trans-Spinal Magnetic Stimulation Promotes Superior Functional Recovery After Severe Spinal Cord Injury in Rats.

Journal of neurotrauma
2026

Deciphering hub genes and immune landscapes related to neutrophil extracellular traps in spinal cord injury: insights from integrated bioinformatics analyses and experiments.

Frontiers in immunology
2026

The Patient Persona of the Self-Management Experience of Home-Based Rehabilitation for Spinal Cord Injury Patients: A Qualitative Study [Letter].

Patient preference and adherence
2026

Predicting recovery trajectories and injury severity following partial crush spinal cord injury in mice.

bioRxiv : the preprint server for biology
2026

Integrated Multi-Omics Analysis Reveals IRF1-Driven Microglial PANoptosis via ZBP1 in Spinal Cord Injury.

Journal of inflammation research
2026

Spinal cord disease following CAR T-cell therapy with axicabtagene ciloleucel in a patient with high-grade B-cell lymphoma.

Leukemia &amp; lymphoma
2026

Effects of an Individualized Dietitian-Led Nutrition Intervention on Body Composition During the First Year After Traumatic Spinal Cord Injury: A Randomized Controlled Trial.

Clinical nutrition ESPEN
2026

Mechanism of Qufeng Huoxue decoction in treating paclitaxel-induced peripheral neuropathy based on network pharmacology and molecular docking.

Neuropeptides
2026

Combined PLGA scaffolds and therapeutic stem cells for locomotion recovery in spinal cord-injured rats: a systematic review and meta-analysis.

Scientific reports
2026

Bridging cortical intentions: brain-computer interfaces for spinal cord injury recovery.

Science bulletin
2026

Ddx20, DEAD-box helicase 20 is essential for maintaining microglial homeostasis.

Experimental neurology
2026

APP as an innate injury-response molecule.

Neurobiology of disease
2026

Current applications of radiomics in neurotrauma.

Neurosurgical review
2026

Advances in Microenvironment-Responsive Biomaterials for Spinal Cord Injury Repair.

Advanced healthcare materials
2026

Alternative Splicing in Central Nervous System: Molecular Mechanisms and Pathophysiological Roles.

Current neuropharmacology
2026

Therapeutic alliance in spinal cord injury rehabilitation: power, institutions, and disabling control.

Physiotherapy theory and practice
2026

Return to Work After Isolated Spinal Injury: Rates, Predictors, and Implications for Occupational Reintegration.

Journal of occupational rehabilitation
2026

Preliminary efficacy of cognitive multisensory rehabilitation for neuropathic pain in chronic spinal cord injury: a phase I randomized controlled trial.

Scientific reports
2026

Corrigendum to "Endplate chondrocyte-derived exosomal miR-128-3p mitigates intervertebral disc degeneration by targeting TRAF6 via the miR-128-3p/TRAF6 axis to suppress pyroptosis" [Int. Immunopharmacol. 143(Part 3) (2024) 113620].

International immunopharmacology
2026

Perinatal Post-Anoxic Spinal Cord Injury: A Barrier to Pallidal Neuromodulation? About 2 Cases.

Movement disorders clinical practice
2026

Repurposing Dexmedetomidine: Early Pharmacological Hypothermia Enhances Neuroprotection and Improves Locomotor and Bladder Functional Recovery After SCI.

The Journal of neuroscience : the official journal of the Society for Neuroscience
2026

Sex-based differences in early neurological recovery after traumatic spinal cord injury.

The journal of trauma and acute care surgery
2026

Transcutaneous spinal cord stimulation plus locomotor training versus sham-stimulation plus locomotor training in chronic spinal cord injury (eWALK): a multicentre, triple-blind, randomised, sham-controlled trial.

EClinicalMedicine
2026

Complete Liberation from Mechanical Ventilation Using Diaphragm Pacing in a Patient with Traumatic Spinal Cord Injury Despite Persistent Unilateral Diaphragmatic Paralysis.

NMC case report journal
2026

Research Progress on the Pyroptosis Mechanism and Related Active Ingredients of Natural Drugs in Spinal Cord Injury.

International journal of general medicine
2026

Central and peripheral neuroplasticity in cervical spinal cord injury following intensive upper limb motor training: a randomised controlled trial protocol.

BMJ open
2026

Feasibility of AI-driven multichannel FES-assisted gait and cycling training in chronic neurological disorders: a case series.

Journal of neuroengineering and rehabilitation
2026

Schwannosis with mature collagen in the spinal cord of a calf.

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
2026

Exosome-Loaded Engineered circBDNF Promotes Spinal Cord Injury Repair Through the PI3K/AKT/mTOR Signaling Axis.

CNS neuroscience &amp; therapeutics
2026

Employment status and barriers to workforce participation among individuals with spinal cord injury: results from the Turkish InSCI Community Survey.

Spinal cord
2026

Liproxstatin-1 improves functional recovery after acute spinal cord injury by inhibiting ferroptosis-induced inflammation.

Molecular and cellular neurosciences
2026

Histone H3K9 lactylation activates the TXNIP/NLRP3 pathway to drive macrophage inflammation after spinal cord injury.

Redox biology
2026

Ulnar compound muscle action potentials predict hand muscle strength 1 year after cervical spinal cord injury: a retrospective analysis.

Annals of physical and rehabilitation medicine
2026

Vocational rehabilitation for traumatic injuries: a survey of current practice and training needs of Australian allied health clinicians.

Brain impairment : a multidisciplinary journal of the Australian Society for the Study of Brain Impairment
2026

Experimental paralysis therapy sparks debate in Brazil.

Science (New York, N.Y.)
2026

Combined repetitive transcranial magnetic stimulation and functional electrical stimulation cycling to improve lower extremity function following incomplete spinal cord injury: Protocol for a pilot randomized controlled trial.

PloS one
2026

Intraspinal Microstimulation of Dorsolateral Funiculus for Coordinated Bladder Control.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
2026

Critical Considerations for Mesenchymal Stem Cell-based Therapies in Osteoarthritis and Spinal Cord Injury: A Narrative Review.

Aging and disease
2026

Midkine Overexpression Promotes Functional Recovery After Spinal Cord Injury by Enhancing Microglial Efferocytosis Via LRP-1.

CNS neuroscience &amp; therapeutics
2026

Postinjury Carnosine Treatment Prevents Neurotrophic Factor Decline in Denervated Muscle and Spinal Cord After Traumatic Injury.

The European journal of neuroscience
2026

Prevalence of Neurogenic Bowel and Lower Urinary Tract Dysfunctions in Brazilians With Traumatic and Nontraumatic Spinal Cord Injury.

Topics in spinal cord injury rehabilitation
2026

Obacunone Promotes Functional Recovery After Spinal Cord Injury by Attenuating Neuroinflammation by Targeting the TLR4/MyD88/p38 MAPK Pathway.

Drug design, development and therapy
2026

Simulated closed-loop magnetic stimulation promotes function recovery and axonal regeneration in spinal cord injury.

Communications biology
2026

Anti-inflammatory treatment confirms rsfMRI and TSPO PET as biomarkers of functional connectivity and neuroinflammation in rat contusion spinal cord injuries.

Scientific reports
2026

Update, translation, cross-cultural adaptation, and validation of Nottingham Stroke Dressing Assessment into Spanish.

Scientific reports
2026

Efficacy of Minocycline in Acute Traumatic Spinal Cord Injury.

Journal of neurotrauma
2026

Emergency spinal stabilization in polytrauma: A clinical marker for tracheostomy rather than an independent risk factor for prolonged ventilation.

Injury
2026

PTGS2 as a potential target for apigenin to promote spinal cord injury repair.

Journal of bioenergetics and biomembranes
2026

Urinary Symptoms and Sexual Dysfunction in National Level Wheelchair Rugby Male Athletes With Spinal Cord Injury.

Neurourology and urodynamics
2026

Multimorbidity patterns in elderly sleep disordered breathing patients.

ERJ open research
2026

Different approach to bone mineral density in non-traumatic spinal cord injury: a comparison with traumatic spinal cord injury.

Journal of rehabilitation medicine
2026

Towards an understanding of disturbed sleep phenotypes after traumatic spinal cord injury.

Journal of rehabilitation medicine
2026

Adipose tissue-derived stromal cells enhance glycolytic metabolism in injured nerve cells via the FOXK1-HK2 axis for spinal cord injury repair.

Journal of translational medicine
2026

Effectiveness of transcranial magnetic stimulation on gait and spasticity in people with spinal cord injury: a systematic review and meta-analysis.

Spinal cord
2026

Restoring rapid natural bimanual typing with a neuroprosthesis after paralysis.

Nature neuroscience
2026

An environmental enrichment facilitates the recovery of lower urinary tract function after spinal cord injury through downmodulation of neurogenic activity in female rats.

World journal of urology
2025

[Effect of Yiyuan moxibustion on regulating ferroptosis in rats with urinary retention after spinal cord injury via the NRF2/GPX4 pathway].

Zhen ci yan jiu = Acupuncture research
2026

[Trends of disease burden on spinal cord injury in China from 1990 to 2023].

Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
2026

[Rehabilitation guidelines and specifications for traumatic spinal cord injury (2025 edition)].

Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
2026

The Italian version of the International Standards for Neurological Classification of Spinal Cord Injury.

European journal of physical and rehabilitation medicine
2026

Effects of early photobiomodulation therapy on motor recovery in patients with incomplete acute cervical spinal cord injury: A multicenter randomized controlled trial.

Journal of orthopaedic translation
2026

The PTBP1-EZH2-DOCK2 axis promotes M1 microglial polarization and exacerbates neuronal apoptosis following spinal cord injury.

Journal of orthopaedic translation
2026

Profibrotic macrophage-derived CXCL4 promotes pericyte-to-myofibroblast transition after spinal cord injury.

Journal of orthopaedic translation
2025

High-energy traumatic spondyloptosis at T8-T9 with complete spinal cord injury: a case report.

Frontiers in surgery
2026

Synergy Feedback Control Predicts Walking Across Multiple Cycles.

bioRxiv : the preprint server for biology
2026

Rewiring the Lung-CNS Axis After Spinal Cord Injury.

Journal of inflammation research
2026

Exoskeletal-Assisted Training in Veterans With Chronic Stroke: A Pilot Study.

Archives of rehabilitation research and clinical translation
2026

A retrospective Chinese study on optical-electromagnetic navigation-guided biportal endoscopic unilateral laminotomy for bilateral decompression in lumbar spinal stenosis: improving precision and efficiency.

Asian spine journal
2026

Expanding the path to spinal cord injury medicine certification: A practice-based solution.

PM &amp; R : the journal of injury, function, and rehabilitation
2026

Functional Goals of Individuals with Cervical Spinal Cord Injury undergoing Surgical Reconstruction for Elbow Extension and their Representation in Standard Assessments.

Archives of physical medicine and rehabilitation
2026

Effects of Acetyl-l-Carnitine on the Mitophagy in the Spinal Cord Injury Progression Through PINK/Parkin Pathway.

Journal of biochemical and molecular toxicology
2026

Dual receptor therapy with pituitrin for spinal cord injury-induced diabetes insipidus: A propensity-matched retrospective cohort study.

Chinese journal of traumatology = Zhonghua chuang shang za zhi
2026

SYK-dependent lipid handling in monocyte-derived macrophages governs functional recovery after spinal cord injury.

Brain research bulletin
2026

Employment and productivity losses from cervical spinal cord injury: a 7-year nationwide cohort study in Taiwan, 2012-2018.

Journal of medical economics
2026

Pharmacological manipulation of the immediate effects of spinal trauma in neonatal rats reveals a crucial role for TRPV4 receptors.

The Journal of physiology
2026

Injectable Metal-Free Carbon Dot-Integrated Hydrogel for Regulating Inflammation via Macrophage Metabolic Reprograming in Spinal Cord Injury Therapy.

ACS nano
2026

High-Thoracic Spinal Cord Injury Impairs Biventricular Function and Blunts Cardiopulmonary Interactions in a Rodent Model.

Journal of neurotrauma
2026

The Role of Phagocytic Cells in the Achilles Tendon.

International journal of molecular sciences
2026

Retrospective Analysis of Cardiovascular Effects of FES Cycling in People with Complete and Incomplete Spinal Cord Injury.

Journal of clinical medicine
2026

Repetitive Transcranial Magnetic Stimulation for Spasticity in Stroke and Other Neuromotor Disorders: A Systematic Review of Randomized Clinical Trials.

Journal of clinical medicine
2026

Integrated Clinical Workflow for Preoperative Planning and Resection of Giant Iliofemoral Heterotopic Ossification Using Three-Dimensional Technologies.

Journal of clinical medicine
2026

Effect of an exosuit on daily life gait performance in individuals with incomplete spinal cord injury: a randomized controlled trial.

Journal of neuroengineering and rehabilitation
2026

Comparison of health outcomes between traumatic spinal cord and cauda equina injuries.

Spinal cord
2026

Lactation and Breastfeeding in Women With Spinal Cord Injury: A Scoping Review.

Journal of human lactation : official journal of International Lactation Consultant Association
2026

GLP-1 receptor agonists as pharmacological treatment for obesity after spinal cord injury: clinical considerations.

Archives of physical medicine and rehabilitation
2026

Persistent histone H3K27 acetylation contributes to excessive scar formation after spinal cord injury through the regulation of microglial cholesterol accumulation.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
2026

Disparities and institutional variation in time to surgery for traumatic cervical spinal cord injury: a multicenter cohort study.

Journal of neurosurgery. Spine
2026

Impact of acupuncture combined with ganglioside therapy on serum inflammatory cytokine levels in acute cervical spinal cord injury without fracture or dislocation.

Medicine
2026

Prevalence and risk factors of cholelithiasis in patients with spinal cord injury: A cross-sectional analysis.

PloS one
2026

Spinal Cord Stimulation Alleviates Spinal Cord Injury-Induced Neuropathic Pain Via m5C-Dependent Regulation of TRAF2.

Neurochemical research
2026

Acute cardio-centric haemodynamic management preserves chronic cardiovascular function in pigs with high-thoracic spinal cord injury.

The Journal of physiology
2026

Late Venous Thromboembolism Chemoprophylaxis and Increased Risk of Deep Venous Thrombosis, Pulmonary Embolism, and Mortality in Patients with Traumatic Spinal Injury.

Journal of the American College of Surgeons
2026

Postacute Ventilator Weaning and Discharge Outcomes in Individuals With Cervical Spinal Cord Injury: A Retrospective Analysis.

Respiratory care
2026

An integrated analysis of spinal cord transcriptome and gut microbiome unravel age-associated host-microbiome interactions following spinal cord injury.

Frontiers in immunology
2026

Improving muscle recruitment via multi-electrode transcutaneous spinal cord stimulation using automated selectivity-driven algorithms.

APL bioengineering
2026

A spatiotemporally controlled MNE@PDA-Diz/GP hydrogel system: enhancing spinal cord injury repair via ROS scavenging, calcium influx inhibition, and macrophage polarization.

RSC advances
2026

Neuroprotective effects of pregabalin in experimental spinal cord injury: An investigation of oxidative stress and antioxidant enzymes in blood and neural tissue.

Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma &amp; emergency surgery : TJTES
2026

Network Pharmacology Combined With Clinical Retrospective Analysis to Investigate the Potential Mechanisms and Clinical Significance of Folate in Treating Spinal Cord Injury.

Pharmacology research &amp; perspectives
2026

Gait analysis methods in people with spinal cord injury: a systematic review.

Journal of neuroengineering and rehabilitation
2026

Predictors of transition readiness in adolescents with neurogenic lower urinary tract dysfunction.

Journal of pediatric urology
2026

Inspiratory muscle training for people with spinal cord injury: An implementation study.

Clinical rehabilitation
2026

TEAD1 Enhances Exosome Secretion and Promotes Exosome-Mediated Tissue Regeneration.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
2026

Impact of delayed diagnosis on surgical management and neurological outcomes in elderly patients with cervical spinal cord injury without radiographic evidence of trauma: a multicenter registry study.

Spinal cord
2026

Perilesional neuromodulation replaces lost sensorimotor function in persons with spinal cord injury.

Nature biomedical engineering
2026

Assistive Robotic Arm to Support Activities of Daily Living in Individuals With Tetraplegia: Protocol for a Real-World Convergent Parallel Mixed Methods Feasibility Study.

JMIR research protocols
2026

Qualitative insights into government financial assistance use after spinal cord injury.

Archives of physical medicine and rehabilitation
2026

Staged Brachialis to Anterior Interosseous Nerve Transfer With Graft for Recovery of Grasp in the Tetraplegic Patient: Technical Report.

Operative neurosurgery (Hagerstown, Md.)
2026

Identification and Verification of Mitochondria-Related Diagnostic Markers of Spinal Cord Injury by WGCNA and Machine Learning.

Behavioural neurology
2026

The effect of breathing exercises and mindset with or without cold exposure on mental and physical health in persons with a spinal cord injury-Results of a randomized controlled trial.

Clinical rehabilitation
2026

Cervical spinal cord injury following near-hanging without associated cervical fracture: a case report.

Journal of spine surgery (Hong Kong)
2026

Insurance disparities are associated with worse post-rehabilitation outcomes in gunshot vs. motor vehicle accident spinal cord injury: a retrospective cohort study.

Journal of spine surgery (Hong Kong)
2026

Life after the hospital: Lived experience of people with traumatic spinal cord injury in a resource-constrained setting - a qualitative study.

The South African journal of physiotherapy
2026

Mesenchymal stem cells and the central nervous system: historical perspectives and future directions.

Frontiers in molecular neuroscience
2026

Treatment of spinal cord injury, by restoration of neuronal networks using a combination of surgery and KCL-286, an orally available retinoic acid receptor β drug.

Frontiers in surgery
2026

Mitochondrial metabolism restoration via Tramiprosate suppresses mitochondrial ROS-driven foamy macrophage senescence post spinal cord injury.

Journal of orthopaedic translation
2026

Prescription Trends and Clinical Decision-Making in Neuropathic Pain Pharmacological Treatment: Results From a Cross-Sectional Survey by the Spanish Pain Society.

European journal of pain (London, England)
2026

The Effect of a Guideline-Based Training Program on the Knowledge Level of Rehabilitation Nurses About Intermittent Catheterization: A Pretest-Posttest Study.

Rehabilitation nursing : the official journal of the Association of Rehabilitation Nurses
2026

A novel cannabidiol-derived small molecule ameliorates lower urinary tract dysfunction in mice with spinal cord injury via suppressing neuroinflammation.

Life sciences
2026

Targeted H2S Delivery System Attenuates Blood-Spinal Cord Barrier Disruption after Spinal Cord Injury by Reshaping the Ferritinophagy Pathway.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
2026

Mechanistic study of locally transplanted bone marrow mesenchymal stem cells combined with erythropoietin in acute spinal cord injury.

Neurological research
2026

Cortical Brain Activation During Robot-Assisted Gait in Humans With Acute and Chronic Spinal Cord Injury: A Functional Near-Infrared Spectroscopy Study.

The European journal of neuroscience
2026

Understanding the Link Between Spirituality and Neurorehabilitation: A Narrative Review.

NeuroRehabilitation
2026

Transcutaneous spinal cord stimulation combined with robot-assisted gait training to improve mobility and balance in spinal cord injury: intramuscular electromyography as a biomarker for functional recovery.

BMC medicine
2026

MedFusion-gP-AKI: development and multicenter validation of a machine learning fusion model for early prediction of KDIGO stage 3 acute kidney injury in critically ill traumatic cervicothoracic spinal cord injury patients.

Renal failure
2026

Neuronal plasticity during motor rehabilitation training after spinal cord injury.

Communications biology
2026

Wearable powered overground exoskeleton reduces dose-dependently the spasticity in individuals with spinal cord injury.

Spinal cord
2026

Forensic and neuropathological characteristics of lethal acute blunt traumatic spinal cord injury.

Journal of forensic sciences
2026

Neuregulin1-ErbB4 Signaling Involved in Acupuncture Promoting Myelin Regeneration in Spinal Cord Injury Rats.

Journal of visualized experiments : JoVE
2026

An Intuitive, Bidirectional, Adaptive Functional Electrical Stimulation System for Hand Rehabilitation.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
2026

In-Depth Real-World Evidence: Assembling a Comprehensive Spinal Cord Injury or Disease Veteran Cohort to Advance Understanding of Neurogenic Lower Urinary Tract Dysfunction.

Neurourology and urodynamics
2026

Pre-stroke Fulfilment of WHO Recommendations for Physical Activity: A Cross-Sectional Study.

Western journal of nursing research
2026

Accuracy and safety of navigated pedicle screw insertion in cervical spine fractures.

Frontiers in surgery
2026

Systemic Interleukin-4 Application Promotes Functional Recovery and Reprograms Neuroinflammatory and Molecular Responses after Spinal Cord Injury in Rats.

Theranostics
2026

PANoptosis: a new perspective for targeting programmed cell death after spinal cord injury.

Frontiers in immunology
2026

Can Transcutaneous Vagus Nerve Stimulation be Effective After Rats' Spinal Cord Injury?

Cureus
2026

Traumatic Cervical Myelopathy Masked by Alcohol Intoxication and Diagnostic Anchoring.

Cureus
2026

Severity Prediction of Traumatic Cervical Spinal Cord Injury With an AI Model Based on MRI Radiomics.

JOR spine
2026

3D bioprinted multifunctional GelMA/TMP scaffold integrated with neural stem cell-derived extracellular vesicles and neural progenitor cells for spinal cord injury repair.

Journal of tissue engineering
2026

NINJ1 monoclonal antibody alleviates neuroinflammation and promotes functional recovery after spinal cord injury by suppressing pyroptosis-mediated DAMPs release.

Neuroscience
2026

Targeting Neuroinflammatory and Regenerative Pathways with Monoclonal Antibodies in Spinal Cord Injury: A Bibliometric Analysis.

World neurosurgery
2026

OSBPL10 alleviates neuronal ferroptosis via lysosomal membrane repair in a PS-dependent manner after spinal cord injury.

Journal of neuroinflammation
2026

APOE-mediated lipid transport prevents C1q-related synaptic loss after spinal cord injury via attenuating macrophage lipid stress.

Journal of neuroinflammation
2026

Study design considerations in clinical trials testing transcutaneous stimulation for spinal cord injury.

Spinal cord
2026

Efficient generation of human dorsal spinal GABAergic progenitors for the treatment of spinal cord injury.

Experimental &amp; molecular medicine
2026

Methyltransferase-like protein 16 suppresses spinal cord injury by regulating microglia polarization via N6-methyladenosine-modified downregulation of MCEMP1.

Journal of neuropathology and experimental neurology
2026

Prediction of neurological prognosis of patients with acute traumatic cervical spinal cord injury using Neurite Orientation Dispersion and Density Imaging (NODDI).

Magnetic resonance imaging
2026

Time-dependent adaptations of damaged neurons and their microenvironment in the regenerating adult zebrafish spinal cord.

Science advances
2026

Unbiased quantification of persistent postural and motor deficits following spinal cord injury in mice.

PloS one
2025

Insights into Astrogliosis, Inflammation Processes, and Emerging Treatments by Exosome Therapy and Low-Level Laser Therapy for Spinal Cord Injury: A Systematic Review.

Journal of lasers in medical sciences
2026

Spinal cord injury-induced overflow incontinence reshapes the activin-follistatin-inhibin axis in mouse bladder and kidney.

Frontiers in molecular biosciences
2026

Precision restoration of complex cervical instability and decompression for neurofibromatosis type I: a case report using patient-specific 3D-printed templates.

Frontiers in surgery
2025

Antibiotic Resistance Identification Among the Patients with Helicobacter pylori Infection: A Cross-sectional Study from Iran.

Middle East journal of digestive diseases
2026

Reconstruction of Stage IV Pressure Ulcers Using Delayed Flaps in a Pediatric Patient With Spinal Cord Injury: A Case Report.

Cureus
2026

Pharmacotherapy in the acute phase of secondary spinal cord injury: an updated narrative review.

European journal of medical research
2026

A mechanistic, imaging-based classification of complete retrograde ejaculation: insights from dynamic transrectal ultrasonography.

European journal of medical research
2026

Angiopep-2-engineered extracellular vesicles derived from spinal cord injury-responsive brown adipose tissue for targeted neuroinflammation modulation.

Journal of nanobiotechnology
2026

In-hospital outcomes and temporal analysis of paralyzed patients with acute myocardial infarction undergoing percutaneous coronary intervention.

Scientific reports
2026

Bladder management for adults with spinal cord injury in the acute hospital setting: A retrospective study.

Spinal cord series and cases
2026

Stereotactic rodent-to-human approximation of the mesencephalic cuneiform nucleus to guide deep brain stimulation.

Brain stimulation
2026

Silencing Adamts2 attenuates fibroblast-mediated fibrosis and promotes axonal regeneration in an in vitro model.

Cellular signalling
2026

Engineered exosomes mediated siNox4 delivery loaded polyzwitterionic hydrogel with electrophysiologic conductivity for synergistic treatment of spinal cord injury via suppressing neuronal ferroptosis.

Biomaterials
2026

Ultra-early surgery within 12 hours is associated with improved short-term outcomes after traumatic cervical spinal cord injury: A retrospective cohort study.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
2026

Recovery rate of functional motor independence during inpatient rehabilitation after traumatic cervical spinal cord injury predicts functional status at years 1 and 5 after surgery: A multicenter, longitudinal cohort study.

The journal of spinal cord medicine
2026

Injectable hydrogel-based localized delivery of IDO-galectin-3 mitigates neuroinflammation and promotes neuronal sparing after spinal cord contusion in rats.

Journal of materials chemistry. B
2026

Rigorous reporting of case reports in spinal cord injury: A collective responsibility.

The journal of spinal cord medicine
2026

Management of Pressure Sore at Tertiary Care Center in Western Nepal: An Observational Study.

JNMA; journal of the Nepal Medical Association
2026

Elderly patient with a calcified upper cervical meningioma acutely worsened by head trauma.

Surgical neurology international
2026

Neuroprotection or Neurotoxicity? Insights from preclinical and clinical studies of methotrexate in spinal cord injury.

Surgical neurology international
2025

Missed T8-T9 Translational Fracture with Intact Neurology: A Case Report.

JNMA; journal of the Nepal Medical Association
2026

Value of Intraoperative Neuromonitoring in Spinal Tuberculosis Surgery: A Case Report of Neurological Compromise with Normal Imaging.

Asian journal of neurosurgery
2026

High MAP3K6 expression in spinal cord injury tissues enhances neuronal apoptosis: insights from multi-omics data integrating WGCNA, machine learning and experimental validation.

The International journal of neuroscience
2026

Matrix Metalloproteinase-Activatable Nanodrug Crossing Blood-Spinal Cord Barrier for On-Demand Drug Release in Spinal Cord Injury Repair.

ACS nano
2026

Focal Estrogen Therapy in Male Rats Promotes Neuronal Survival and Reduces Denervation Atrophy After Spinal Cord Injury via Modulation of β-Catenin and NF-κB.

Neurochemical research
2026

Dual strategies for neural injury repair: Targeted modulation of reactive astrocytes and functional astrocyte transplantation.

Neural regeneration research
2026

Role of mechanobiology in neuroregeneration.

Neural regeneration research
2026

Challenges with Tracking Post Concussive Symptoms Using the Neurobehavioral Symptom Inventory in Active Duty Service Members with Mild Traumatic Brain Injury.

Military medicine
2026

Current Advancements in the Arsenal for Spinal Cord Injury Repair: Novel Drug Formulations.

International journal of nanomedicine
2026

International Delphi consensus on feminising genital surgery in assigned-male-at-birth individuals.

BJU international
2026

Motor imagery BCI enables more practical and user-friendly exoskeleton control than smartwatch for users with spinal cord injury: a preliminary study.

Journal of neuroengineering and rehabilitation
2026

Paired associative stimulation with a high-intensity cortical component and a high-frequency peripheral component in treatment of neuropathic pain after incomplete spinal cord injury - a pilot trial.

Spinal cord series and cases
2026

The profile of persons with traumatic spinal cord injury and the associated factors of length of stay in a rehabilitation centre, in South Africa.

Spinal cord
2026

Influence of multiple trauma on the effect of transfusion strategies in patients with traumatic brain injury: a sub-study of the HEMOTION trial.

Intensive care medicine
2026

The efficacy of surgical management in post traumatic syringomyelia: A systematic review.

The journal of spinal cord medicine
2026

Extracellular Vesicle-Mediated Precision Delivery of Paclitaxel Activates Mitophagy to Promote Repair after Spinal Cord Injury.

ACS nano
2026

Glycolysis-related gene signatures in spinal cord injury pathophysiology identification through integrative gene expression analysis.

Frontiers in genetics
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Doenças relacionadas

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Ddx20, DEAD-box helicase 20 is essential for maintaining microglial homeostasis.
    Experimental neurology· 2026· PMID 41864319mais citado
  2. Repurposing Dexmedetomidine: Early Pharmacological Hypothermia Enhances Neuroprotection and Improves Locomotor and Bladder Functional Recovery After SCI.
    The Journal of neuroscience : the official journal of the Society for Neuroscience· 2026· PMID 41862205mais citado
  3. Central and peripheral neuroplasticity in cervical spinal cord injury following intensive upper limb motor training: a randomised controlled trial protocol.
    BMJ open· 2026· PMID 41857841mais citado
  4. Exosome-Loaded Engineered circBDNF Promotes Spinal Cord Injury Repair Through the PI3K/AKT/mTOR Signaling Axis.
    CNS neuroscience &amp; therapeutics· 2026· PMID 41857479mais citado
  5. Liproxstatin-1 improves functional recovery after acute spinal cord injury by inhibiting ferroptosis-induced inflammation.
    Molecular and cellular neurosciences· 2026· PMID 41856443mais citado
  6. Immediate Consequences of a Spinal Cord Injury During Development: Unique Insights From Ex Vivo Models.
    Neural Plast· 2026· PMID 41995146recente
  7. Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar-Limited Repair in Adult Spinal Cord Injury.
    Adv Sci (Weinh)· 2026· PMID 41995115recente
  8. Duodenal perforation following right nephrectomy in a paraplegic patient with pyonephrosis: a case report and clinical insights.
    Front Med (Lausanne)· 2026· PMID 41994430recente
  9. Case Report: Transverse myelitis following CAR-T cell therapy for post-transplant lymphoproliferative disorder.
    Front Immunol· 2026· PMID 41993175recente
  10. The Minimal Detectable Change for Balance and Balance Confidence After Chronic Spinal Cord Injury.
    J Neurol Phys Ther· 2026· PMID 41992379recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:90058(Orphanet)
  2. MONDO:0043797(MONDO)
  3. GARD:19109(GARD (NIH))
  4. Busca completa no PubMed(PubMed)
  5. Artigo Wikipedia(Wikipedia)
  6. Q1415275(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Lesão traumática da medula espinhal
Compêndio · Raras BR

Lesão traumática da medula espinhal

ORPHA:90058 · MONDO:0043797
Prevalência
1-5 / 10 000
Herança
Not applicable
CID-10
T09.3 · Traumatismo de medula espinhal, nível não especificado
CID-11
Ensaios
36 ativos
Medicamentos
6 registrados
Início
All ages
Prevalência
32.0 (Europe)
MedGen
UMLS
C0037929
Wikidata
Wikipedia
Papers 10a
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