Meningite meningocócica

Investigating Gender and Sex Differences in Immune Responses Through Vaccination of Transgender and Cisgender Persons

NCT06832514

RECRUTANDO

Safety, Tolerability, and Immunogenicity of MenABCWY Administered on Different Dosing Schedules in Healthy Adolescents

NCT05087056

A Study on the Immune Response and Safety of a Vaccine Against N. Meningitidis Serogroup B Infection in Healthy Infants From 2 Months of Age

NCT06113198

A Clinical Trial of ACYW135 Group Meningococcal Polysaccharide Conjugate Vaccine (CRM197 Vector) in 18-59 Year Olds

NCT06226714

A Clinical Trial of ACYW135 Group Meningococcal Polysaccharide Conjugate Vaccine (CRM197 Vector) in 7 to 17 Year Olds

NCT06700148

NCT06832514 · Investigating Gender and Sex Differences in Immune Responses…Recrutando

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NCT05087056 · Safety, Tolerability, and Immunogenicity of MenABCWY Adminis…Ativo

Outros ensaios clínicos

130 ensaios clínicos encontrados, 7 ativos.

Distribuição por fase

PHASE2

NCT06113198 · A Study on the Immune Response and Safety of a Vaccine Again…Ativo

NCT06226714 · A Clinical Trial of ACYW135 Group Meningococcal Polysacchari…Ativo

NCT06700148 · A Clinical Trial of ACYW135 Group Meningococcal Polysacchari…Ativo

NCT06131554 · A Clinical Trial to Evaluate the Immunogenicity and Safety o…Ativo

NCT07374510 · Phase Ia Clinical Trial of Group ACYW135X Meningococcal Conj…Em breve

PHASE1

NCT03549325 · A Study Assessing Colonisation & Immunogenicity After Nasal …Encerrado

NA

NCT04685850 · Long-term Sequelae of Childhood Meningitis and Meningococcal…Encerrado

NCT03295318 · Clinical Study of Meningococcal ACYWX Conjugate Vaccine, in …Concluído

PHASE2

NCT04665791 · A Human Controlled Infection Study with Neisseria Lactamica …Concluído

NA

NCT04061382 · Sero-epidemiological Survey of England in 2019/2020 - COVID-…Concluído

NCT04707391 · Immunogenicity and Safety Study of GSK's MenABCWY Vaccine in…Concluído

NCT05252715 · Immunogenicity and Safety of Meningococcal ACYW135 Polysacch…UNKNOWN

NCT06337071 · A Study of the ACYW135 Meningococcal Polysaccharide Conjugat…UNKNOWN

PHASE2

NCT03493919 · A Sourcing Study to Collect Human Blood Samples From Healthy…Concluído

NCT02864927 · Postmarketing Surveillance Study for Use of Menactra® in the…Concluído

NCT02699840 · Observational Safety Study of Menactra® Administered Under S…Concluído

NCT02752906 · Immunogenicity and Safety of a Booster Dose of an Investigat…Concluído

NCT03205371 · Immunogenicity and Safety of a Meningococcal Conjugate Vacci…Concluído

Ver todos no ClinicalTrials.gov

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Publicações mais relevantes

Timeline de publicações

351 papers (10 anos)

#1

Evaluation of Immune Risk Factors for Developing Complications After Bacterial Meningitis in Children.

Journal of child neurology2026 Apr

This study investigates selected components of the immune system and the prevalence of single-nucleotide polymorphisms in genes involved in the immune response in children following bacterial meningitis, with particular focus on their potential role in the development of postinfectious complications. The study included 47 children hospitalized with pneumococcal or meningococcal meningitis between 2010 and 2020. Analyses involved leukocyte profiles, immunoglobulin levels (IgA, IgM, IgG), complement activity (C3, C4, CH50), and 11 single-nucleotide polymorphisms across 7 genes. Data on complications were collected from medical records, follow-ups, and patient surveys. Complications occurred in 59.6% of cases, with cognitive impairment, focal neurologic deficits, subdural effusion, and hearing disorders being most common. CH50 defects showed a statistical trend toward an increased risk of neurologic complications (P = .064), and the TIRAP rs8177374 single-nucleotide polymorphism demonstrated a borderline trend toward significance (P = .054). Bacterial meningitis may lead to long-term complications. Complement system disturbances and genetic predispositions are important prognostic factors influencing outcomes.

#2

Nigeria's post-COVID-19 vaccine manufacturing ambitions: Opportunities and regional implications.

Journal of public health in Africa2026

Global health emergencies consistently expose and exacerbate vaccine inequities, with high-income countries prioritising their populations and leaving low- and middle-income countries (LMICs) facing delays and shortages. Diseases primarily affecting LMICs receive limited attention from global vaccine developers because of perceived low market value and limited financial return, further entrenching these disparities. Africa's limited investment in vaccine manufacturing has heightened its vulnerability during outbreaks, including yellow fever, Ebola, meningococcal meningitis, mpox, and most recently, coronavirus disease 2019 (COVID-19). This study examines the barriers to vaccine equity in Africa and critically analyses Nigeria's post-COVID-19 efforts to establish a viable, local vaccine manufacturing ecosystem. The research focuses on Nigeria within the broader African vaccine manufacturing landscape, using it as a case study to explore both national and continental dynamics. The study draws on document analysis of strategic plans, regulatory reports, and partnership announcements, complemented by qualitative insights from key informant interviews with stakeholders involved in vaccine policy, regulation, and production in Nigeria and across West Africa. Post-pandemic momentum has catalysed significant shifts: Nigeria has developed a national vaccine manufacturing strategy and secured international partnerships and financing commitments. The regulatory authority, National Agency for Food and Drug Administration and Control (NAFDAC), achieved the World Health Organization (WHO) Maturity Level 3 status, marking critical progress. Nonetheless, persistent gaps remain in research and development capacity, workforce development, regulatory agility, and infrastructure readiness. While Nigeria has made notable progress since the COVID-19 pandemic, sustainable vaccine manufacturing requires long-term investment in research and development, policy reform, skills development, and regional cooperation. Failure to address these challenges systematically risks undermining current gains. This article provides insights to support ongoing and future investments in Nigeria's vaccine manufacturing sector, guiding government policy, international partnerships, and potential investors.

#3

Epidemiology and characteristics of bacterial meningitis of children with cerebrospinal fluid leakage or cochlear implant.

Journal of the Pediatric Infectious Diseases Society2026 Mar 09

Cerebrospinal (CSF) fluid leakage is a recognized risk factor for bacterial meningitis. Few data are published concerning bacterial meningitis in children with cerebrospinal fluid leakage, and the impact of 13 valent pneumococcal conjugate vaccination (PCV13) in this population is not well known. The aim of this study was to describe the epidemiology of bacterial meningitis in children with known CSF leakage.Methods: Among all bacterial meningitis in children > 3 months old, we analyzed those with known CSF leakage (meningeal breach and/or cochlear implant resulting in meningitis) in a nationwide prospective cohort between 2001 and 2024 in France, with 227 pediatric wards and 168 microbiology departments. Of 5,879 cases of bacterial meningitis in children over 3 months old, 251 (4.3%) were associated with known CSF leakage. In this population, Streptococcus pneumoniae (78.9%) was the most frequent bacteria involved, followed by Haemophilus influenzae (10%), mainly non typeable strains. Two cases of Neisseria meningitidis were recorded and only in children with cochlear implant. For children with known CSF leakage, in late PCV13 period, PCV13, PCV15, PCV20, PCV21 and PPSV23 serotypes accounted for 14%, 16.3%, 37.2%, 79.1% and 27.9%, respectively. In this population, serotype 23B was the most frequent (18.6%), followed by 11A (9.3%), 15A (9.3%), 19F (7%), 3 (4.7%) and 19A (2.3%). Bacterial meningitis in children with known CSF leakage is largely due to pneumococci and now mainly due to serotypes not included in PCV13. Only two cases of meningococcal meningitis were found and only for children with cochlear implant.

#4

Estimating the impact of decreasing vaccination response times for outbreaks of vaccine-preventable diseases in low- and middle-income countries.

BMC global and public health2026 Jan 21

The 7-1-7 targets are gaining traction as measurable targets for assessing a country's readiness to detect and respond to outbreaks of infectious diseases. The targets are outbreak detection within 7 days of emergence, notification to health authorities within 1 day, and key early response actions commenced within another 7 days. For outbreaks of measles, cholera, yellow fever, and meningococcal meningitis, we estimated the impact of initiating outbreak response immunisation (ORI) within 15 days of outbreak emergence, relative to the mean ORI response time for each disease in low- and middle-income countries (LMICs) since 2000. Initiating ORI within 15 days of outbreak emergence aligns with the 7-1-7 targets and supports outbreak containment. Using agent-based models for four diseases, a status quo and series of 'Faster response' scenarios were compared for simulated outbreaks of each disease, with a 15-day ORI response time as the minimum. The Starsim modelling framework was used to build the models to provide a single common software and analysis architecture for all models while having the flexibility to account for very different modes of transmission across the diseases being modelled. The models were calibrated to epidemiological and programmatic response data for 51 measles, 40 cholera, 24 meningococcal meningitis, and 88 yellow fever outbreaks in LMICs. In a synthetic model population, a 15-day ORI response could avert: 80% of cases from cholera outbreaks relative to a historical response time of 105 days, 35% of cases from meningococcal meningitis outbreaks relative to a historical response time of 75 days, 0-35% of cases from yellow fever outbreaks relative to a historical response time of 105 days (depending on routine vaccine coverage and environmental suitability), and 0-55% of cases from measles outbreaks relative to a historical response time of 120 days (depending on routine vaccine coverage). Improvements made to ORI response time could reduce disease burden and decrease the risk of large outbreaks of vaccine-preventable diseases in LMICs. Efforts to improve ORI timeliness should be prioritised to higher risk settings, and it was clear that even a slow vaccination response was beneficial relative to no response at all.

#5

High risk and low incidence diseases: Meningococcal disease.

The American journal of emergency medicine2026 Jan

Meningococcal disease is a serious condition that carries with it a high rate of morbidity and mortality. This review highlights the pearls and pitfalls of meningococcal disease, including presentation, diagnosis, and management in the emergency department (ED) based on current evidence. Invasive meningococcal disease is a severe, rapidly progressive infection caused by Neisseria meningitidis associated with high morbidity and mortality. Emergency physicians must maintain a high index of suspicion, as early symptoms may mimic a benign viral illness, potentially delaying treatment with serious consequences. This early phase is typically followed by the emergence of more specific features of meningococcal infection, such as meningococcal meningitis, meningococcemia, or a combination of both. Suspected cases warrant immediate implementation of droplet precautions and strict isolation to reduce the risk of healthcare worker exposure and secondary transmission. Prompt treatment, ideally within one hour of clinical suspicion, is essential. Management includes empiric parenteral antibiotics, and in cases of suspected meningitis, adjunctive corticosteroids should be administered prior to or concurrently with the first antibiotic dose. Patients with meningococcemia and shock require aggressive fluid resuscitation, vasopressor support as indicated, and prompt admission to a critical care setting. All close contacts of confirmed cases should receive chemoprophylaxis, regardless of their meningococcal immunization status. An understanding of meningococcal disease can assist emergency clinicians in diagnosing and managing this potentially deadly disease.

Publicações recentes

Meningococcal Meningitis Complicated by Cerebral Venous Sinus Thrombosis Presenting as Pseudo-Subarachnoid Hemorrhage in a Toddler: A Case Report.

Cureus2026 Mar

Neonatal invasive meningococcal disease: Clinical case from Saudi Arabia and updated review of reported cases.

J Infect Public Health2026 May

First serogroup Y meningitis outbreak in Hubei Province Central China linked to adolescent immunization gaps.

Sci Rep2026 Mar 26

New title: Re-evaluating environmental associations with meningitis risk across Africa.

Wellcome Open Res2025

Nigeria's post-COVID-19 vaccine manufacturing ambitions: Opportunities and regional implications.

J Public Health Afr2026

Ver todas no PubMed

📚 EuropePMC825 artigos no totalmostrando 198

New title: Re-evaluating environmental associations with meningitis risk across Africa.

Wellcome open research

Journal of public health in Africa

Nigeria's post-COVID-19 vaccine manufacturing ambitions: Opportunities and regional implications.

Journal of the Pediatric Infectious Diseases Society

Epidemiology and characteristics of bacterial meningitis of children with cerebrospinal fluid leakage or cochlear implant.

Journal of human immunity

Disseminated gonococcal infection secondary to a rare homozygous mutation resulting in complement factor I deficiency.

BMC global and public health

Estimating the impact of decreasing vaccination response times for outbreaks of vaccine-preventable diseases in low- and middle-income countries.

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]

[Epidemiological characteristics and analysis of onset-to-diagnosis and diagnosis-to-report time intervals for meningococcal meningitis in Zhejiang Province from 2014 to 2024].

Infection and drug resistance

A Pediatric Case of Serogroup Y Meningococcal Meningitis in a 12-Year-Old Boy Combined with Respiratory Infection of Three Species of Viruses in China.

Acta paediatrica (Oslo, Norway : 1992)

Parents Who Accepted the Meningococcal Conjugate Vaccine Were More Aware of the Severity of the Disease and Risks.

Journal of public health research

Investigating health professionals' understanding and risk perception of the effect of climate change on health. A cross-sectional study at three hospitals in Sunyani, Ghana.

Anti-cytokine autoantibodies linked to susceptibility, bacterial load, and outcome in pneumococcal meningitis: prospective cohort studies in CNS infections, Alzheimer's disease, and Parkinson's disease.

EBioMedicine

The American journal of emergency medicine

High risk and low incidence diseases: Meningococcal disease.

Development of MenFive®, an affordable pentavalent meningococcal conjugate vaccine (ACYWX) for Africa and beyond.

Journal of child neurology

Evaluation of Immune Risk Factors for Developing Complications After Bacterial Meningitis in Children.

Modelling of strategies for the introduction and routine use of multivalent meningococcal conjugate vaccines (MMCVs) in the African meningitis belt.

European journal of medical research

Neisseria Meningitidis Carriage Among Hajj and Umrah Pilgrims: A Systematic Review and Meta-Analysis.

Infectious Disease Modelling

Modeling Neisseria meningitidis transmission dynamics and the impact of pentavalent vaccination targeting serogroups A, C, W-135, Y, and X in the African meningitis belt.

Current issues in molecular biology

Design of New Primer Sets for the Development of a Loop-Mediated Isothermal Amplification for Rapid Detection of Neisseria meningitidis.

Application of a novel virus-like particle platform to the development of Neisseria vaccines.

Journal of biotechnology

International journal of surgery (London, England)

Bibliometric visualization of global research trends in meningococcal meningitis.

Estimating the historical impact of outbreak response immunisation programmes across 210 outbreaks in low and middle-income countries.

BMJ global health

Current medical research and opinion

Meningococcal B vaccine co-administration in older adolescents and young adults and potential missed opportunities for vaccination in the United States: a retrospective claims database analysis.

Sequelae following an epidemic of meningococcal meningitis in Niger in 2022.

Epidemiological and Clinical Features of Meningococcal Meningitis in Infants - China, 2006-2023.

China CDC weekly

Modeling protective meningococcal antibody responses and factors influencing antibody persistence following vaccination with MenAfriVac using machine learning.

A Case Cluster of Aseptic Meningitis Associated With a Newly Identified Recombinant Echovirus 6/Coxsackievirus B1 Enterovirus.

Mathematical biosciences and engineering : MBE

Modelling human response to information in voluntary vaccination behaviour using epidemic data.

A Cluster of Meningococcal Serogroup W135 Infections: A Case Series.

Cureus

Diagnostic microbiology and infectious disease

Successfully treated myopericarditis and acute heart failure due to severe Neisseria meningitidis infection: a case report.

Spinal Phlegmon Secondary to Neisseria meningitidis Meningitis With Possible Herpes Simplex Virus 1 Co-infection in an Immunocompetent Pediatric Patient.

Cureus

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

Outbreak of Neisseria meningitidis serogroup B in Aragón, Spain, January to February 2025.

Hydrocephalus and Cerebral Small Vessel Disease in an Adult With Meningococcal Meningitis and Dilated Cardiomyopathy: A Fatal Outcome.

Clinical case reports

Zhonghua er ke za zhi = Chinese journal of pediatrics

[Clinical characteristics and serogroup analysis of 16 pediatric cases of meningococcal meningitis].

Journal of infection and public health

Addressing challenges in meningococcal meningitis prevention: Key highlights from recent cases in Xining, China.

Travel medicine and infectious disease

Vaccinations for Hajj: Enhancing health and global health security.

Annals of Indian Academy of Neurology

Assessing the Impact of TLR4 rs4986790 Polymorphism on Bacterial Meningitis Risk: A Systematic Review and Meta-Analysis.

Characterisation and Immunogenicity of Neisseria cinerea outer membrane vesicles displaying NadA, NHBA and fHbp from Neisseria meningitidis serogroup B.

Frontiers in immunology

Journal of infection and public health

Hajj vaccination strategies: Preparedness for risk mitigation.

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi

[Analysis on incidence trend of meningococcal meningitis and major pathogenic serogroups of Neisseria meningitidis in China, 1990-2023].

Economic evaluation on meningococcal vaccination strategies among children under nine years of age in Zhejiang province, China.

Fatal case of meningococcal meningitis in a child from rural Bhutan: A case report.

Clinical case reports

Deutsche medizinische Wochenschrift (1946)

[Community-Acquired Bacterial Meningoencephalitis: The New Guideline].

Andes pediatrica : revista Chilena de pediatria

[Meningococcal meningitis in Chile between 1990 and 2019].

The American journal of case reports

Emerging Meningococcal B Meningitis in Japan: A Case Report of a 50-Year-Old Japanese Man with Diabetes.

European journal of case reports in internal medicine

Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD) Initially Presenting as Septic Meningoencephalitis in a 16-Year-Old Male.

Diagnostics (Basel, Switzerland)

Developing a Novel Murine Meningococcal Meningitis Model Using a Capsule-Null Bacterial Strain.

Turkish journal of medical sciences

Positive effects of health behaviors acquired during the COVID-19 pandemic process on the prevention of other infectious diseases.

The Pediatric infectious disease journal

Severe Meningococcal Meningitis Revealing a Novel Form of Properdin Deficiency in a Previously Healthy 13-Year-old Child.

Annali di igiene : medicina preventiva e di comunita

Management of a Neisseria meningitidis case: factors that guarantee the effectiveness of supporting Public Health actions.

Determining the bacterial and viral meningitis trend in Iraq from 2007 till 2023 using joinpoint regression.

Heliyon

PCR-positive meningococcal CSF infection without pleocytosis but high IL-6 and IL-8.

Infection

Pictures in Medicina Intensiva. Endogenous endophthalmitis in a meningococcal meningitis case.

Medicina intensiva

The Pan African medical journal

Neisseria meningitidis with decreased susceptibility to penicillin G and molecular characterization of the penA gene in strains isolated at University Hospital Centers of Casablanca and Marrakech (Morocco).

An Outbreak of Serogroup Y Meningococcal Meningitis in a Private Secondary Vocational School - Guangzhou City, Guangdong Province, China, 2023.

China CDC weekly

Annals of clinical microbiology and antimicrobials

An isothermal CRISPR- based lateral flow assay for detection of Neisseria meningitidis.

The Pan African medical journal

Investigation of a bacterial meningitis cluster in a refugee settlement, Obongi District, Uganda, March 2023.

Medical science monitor : international medical journal of experimental and clinical research

Etiology, Clinical Presentation, and Outcomes of Bacterial Meningitis in Adult Patients: A Retrospective Study in Lithuania (2018-2021).

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia

Meningococcal meningitis in Spain in the Horizon 2030: A position paper.

Determine the factors affecting the time to recovery of children with bacterial meningitis at Jigjiga university referral hospital in the Somali Regional State of Ethiopia: using the parametric shared frailty and AFT models.

BMC research notes

The epidemiological profile of incidence and mortality from epidemics in complex humanitarian emergencies from 1990 to 2022 - A scoping review.

Twins with meningitis due to Neisseria meningitidis.

Germs

Pneumonia in childhood bacterial meningitis-Experience from three continents.

Journal of clinical immunology

Novel Pathogenic C5 Gene Variants in a Patient with Neisseria Meningitis and Diffuse Cutaneous HSV-1 Infection.

What Works for Controlling Meningitis Outbreaks: A Case Study from China.

Vaccines

Journal of preventive medicine and hygiene

Impact of the COVID-19 pandemic on the infectious disease epidemiology.

The Pediatric infectious disease journal

Vaccine-preventable Pediatric Acute Bacterial Meningitis in France: A Time Series Analysis of a 19-Year Prospective National Surveillance Network.

Frontiers in cellular and infection microbiology

Neisseria meningitidis accumulate in large organs during meningococcal sepsis.

Genetic variants linked to the phenotypic outcome of invasive disease and carriage of Neisseria meningitidis.

Microbial genomics

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

Community pharmacists' knowledge, prospective and practice towards health related illness at Hajj and Umrah: A cross sectional study.

Association between contextual factors and coverage of the Acwy meningococcal vaccine, after three years of its overdue, in the vaccination calendar of adolescents in the state of Minas Gerais, Brazil: global space regressions.

Internal medicine (Tokyo, Japan)

Serious Bacterial Infections Associated with Eculizumab: A Pharmacovigilance Study.

Accuracy of antigen tests for meningococcal meningitis in cerebrospinal fluid: A diagnostic meta-analysis.

The Lancet regional health. Europe

Trends in laboratory-confirmed bacterial meningitis (2012-2019): national observational study, England.

The Medical journal of Australia

Meningococcal B septic shock, reactive pericarditis and public health.

MMW Fortschritte der Medizin

[Invasive meningococcal disease: increased risk and vaccination prevention for immunocompromised patients].

Journal of clinical medicine

Acute Bacterial Meningitis in Healthy Adult Patients: A Prospective Cohort Study.

Cerebrovascular complications in patients with community-acquired bacterial meningitis: occurrence and associated factors in the COMBAT multicenter prospective cohort.

Serogroup B Meningococcal Sepsis and Meningitis Associated With Meningococcal Acute Otitis Media, and Paranasal Sinusitis in an Infant: A Case Report.

Cureus

The Lancet regional health. Europe

Epidemiology, clinical features and outcome of adults with meningococcal meningitis: a 15-year prospective nationwide cohort study.

Incidence and trends of 17 notifiable bacterial infectious diseases in China, 2004-2019.

Oxford medical case reports

Guillain-Barre syndrome complicating Neisseria meningitidis infection.

Trends in Neisseria meningitidis serogroups amongst patients with suspected cerebrospinal meningitis in the meningitis belt of Ghana: a 5-year retrospective study.

Tropical medicine and infectious disease

Association between Meningococcal Meningitis and Santa Ana Winds in Children and Adolescents from Tijuana, Mexico: A Need for Vaccination.

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]

[Immunogenicity of group A+C meningococcal polysaccharide conjugate vaccine in infants: A phase Ⅲ clinical trial study].

Transtentorial herniation syndrome from meningococcal meningitis in a young woman: the case for neurocritical care.

BMJ case reports

Revista internacional de andrologia

[Neisseria meningitidis and the increase of oral sex. A case report].

Pathogens (Basel, Switzerland)

Highly Similar Sequences of Mature IgA1 Proteases from Neisseria meningitidis, Neisseria gonorrhoeae and Haemophilus influenzae.

Vaccines and Senior Travellers.

Frontiers in aging

The epidemiology of meningococcal meningitis: multicenter, hospital-based surveillance of meningococcal meningitis in Iraq.

IJID regions

Prevalence of Neisseria meningitidis serogroups in invasive meningococcal disease in China, 2010 - 2020: a systematic review and meta-analysis.

Indian journal of medical microbiology

A systematic review and meta-analysis on the antibiotic resistance of Neisseria meningitidis in the last 20 years in the world.

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]

[Research progress on immunogenicity evaluation of serogroup B meningococcal vaccine].

Long-term impact of invasive meningococcal disease in children: SEINE study protocol.

Application of a Neisseria meningitidis antigen microarray to identify candidate vaccine proteins from a human Phase I clinical trial.

A database study of clinical and economic burden of invasive meningococcal disease in France.

One-Year Sequelae and Quality of Life in Adults with Meningococcal Meningitis: Lessons from the COMBAT Multicentre Prospective Study.

Advances in therapy

Antibiotics (Basel, Switzerland)

The Collateral Effect of COVID-19 on the Epidemiology of Airborne/Droplet-Transmitted Notifiable Infectious Diseases in Taiwan.

Journal of microbiology (Seoul, Korea)

Availability of polyamines affects virulence and survival of Neisseria meningitidis.

Impact of COVID-19 pandemic on vaccination against meningococcal C infection in Brazil.

Vaccine: X

Enhancing Meningococcal Genomic Surveillance in the Meningitis Belt Using High-Resolution Culture-Free Whole-Genome Sequencing.

Einstein (Sao Paulo, Brazil)

Epidemiology and treatment of sepsis at a public pediatric emergency department.

Low Adherence to Pneumococcal Vaccination in Lung Cancer Patients in a Tertiary Care University Hospital in Southern Germany.

Vaccines

The Ulster medical journal

Does social deprivation correlate with meningococcal MenACWY, Hib/MenC and 4CMenB/Meningococcal Group B vaccine uptake in Northern Ireland?

European journal of pediatrics

Genetic workup as a complementary tool for the diagnosis of primary complement component deficiencies: a multicenter experience.

Impact of meningococcal C conjugate vaccine on incidence of invasive meningococcal disease in an 18-year time series in Brazil and in distinct Brazilian regions.

Meningococcal Disease Burden in India: A Systematic Review and Meta-Analysis.

Microbiology insights

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi

[Epidemiological and Etiologic characteristics of Meningococcal meningitis in Xinjiang Uygur Autonomous Region,1960-2019].

Journal of paediatrics and child health

Invasive meningococcal disease: Should the first episode prompt further investigation?

Journal of tropical medicine

Impact of MenAfriVac on Meningococcal A Meningitis in Cameroon: A Retrospective Study Using Case-by-Case-Based Surveillance Data from 2009 to 2015.

An overview of bacterial meningitis epidemics in Africa from 1928 to 2018 with a focus on epidemics "outside-the-belt".

Assessment of a Multiplex LAMP Assay (Eazyplex® CSF Direct M) for Rapid Molecular Diagnosis of Bacterial Meningitis: Accuracy and Pitfalls.

Microorganisms

Innovation (Cambridge (Mass.))

Impact of immunization programs on 11 childhood vaccine-preventable diseases in China: 1950-2018.

Pneumococcal Meningitis Outbreaks in Africa, 2000-2018: Systematic Literature Review and Meningitis Surveillance Database Analyses.

Analysis of spatial-temporal distribution of notifiable respiratory infectious diseases in Shandong Province, China during 2005-2014.

BMC public health

The Pan African medical journal

The burden of meningococcal meningitis in the African Meningitis Belt, from 2009 to 2014: a trend analysis.

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia

[Primary meningococcal arthritis].

Journal of education & teaching in emergency medicine

Meningococcal Meningitis with Waterhouse-Friderichsen Syndrome.

Pakistan journal of pharmaceutical sciences

Identification and structural investigation of potential novel drug candidates against lethal human pathogen.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

Genetic variations of toll-like receptors: Impact on susceptibility, severity and prognosis of bacterial meningitis.

Pathogens (Basel, Switzerland)

Meningococcal Carriage among Household Contacts of Patients with Invasive Meningococcal Disease in Kathmandu, Nepal: A Longitudinal Study.

Lactate-Induced Dispersal of Neisseria meningitidis Microcolonies Is Mediated by Changes in Cell Density and Pilus Retraction and Is Influenced by Temperature Change.

Infection and immunity

Assessing vaccine introduction and uptake timelines in Gavi-supported countries: are introduction timelines accelerating across vaccine delivery platforms?

BMJ global health

Booster immunization of meningococcal meningitis vaccine among children in Hangzhou, China, 2014-2019.

Frontiers in public health

Antimeningococcal Vaccination Coverage Among Healthcare Workers in an Italian University Hospital.

Serogroup B invasive meningococcal disease (IMD) outbreak at a Japanese high school dormitory: An outbreak investigation report from the first IMD outbreak in decades.

Journal of paediatrics and child health

Meningococcal serotype W septic arthritis: Case series in children.

Meningococcal vaccines in China.

Genetic Variation in Neisseria meningitidis Does Not Influence Disease Severity in Meningococcal Meningitis.

Frontiers in medicine

International journal of molecular sciences

Interactions and Signal Transduction Pathways Involved during Central Nervous System Entry by Neisseria meningitidis across the Blood-Brain Barriers.

Meningococcal vaccines and protein-energy undernutrition in children in the African meningitis belt.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Herpes simplex virus type 2 myelitis mimicking ICU-acquired weakness as a complication of meningococcal meningitis: A case report.

Unusual presentation of meningococcal meningitis in the elderly and utility of CSF PCR testing.

Access microbiology

Proceedings of the National Academy of Sciences of the United States of America

Structure of a protective epitope reveals the importance of acetylation of Neisseria meningitidis serogroup A capsular polysaccharide.

4CMenB vaccine induces elite cross-protective human antibodies that compete with human factor H for binding to meningococcal fHbp.

PLoS pathogens

Rapid Diagnosis of Meningococcal Meningitis in a Patient With Familial Mediterranean Fever by the FilmArray Meningitis/Encephalitis Panel: A Case Report.

The Neurohospitalist

Primary immunization of meningococcal meningitis vaccine among children in Hangzhou, China, 2008-2017.

Profile and complexity of travel medicine consultations in Chile: unicentric cross-sectional study.

BMJ open

Meningococcal meningitis and COVID-19 co-infection.

BMJ case reports

European journal of case reports in internal medicine

A Case of Meningococcal and HSV-2 Meningitis in a Patient Being Treated with Ustekinumab for Pityriasis Rubra Pilaris.

Diversification in immunogenicity genes caused by selective pressures in invasive meningococci.

Microbial genomics

Rhode Island medical journal (2013)

An Update on Meningococcal Vaccination.

Journal of visualized experiments : JoVE

Neisseria meningitidis Infection of Induced Pluripotent Stem-Cell Derived Brain Endothelial Cells.

Long-term impacts of MenC vaccination campaign in the Salvador, Brazil metropolitan region: A comparison of pre- and post-vaccine periods.

Journal of digestive diseases

The important role of immunization in alcoholic and non-alcoholic chronic liver disease: A population-based study.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

Miller Fisher syndrome following meningococcal meningitis.

Combined therapy with ceftriaxone and doxycycline does not improve the outcome of meningococcal meningitis in mice compared to ceftriaxone monotherapy.

[Rinsho ketsueki] The Japanese journal of clinical hematology

[Paroxysmal nocturnal hemoglobinuria treated with eculizumab in Wakayama, Japan: a retrospective analysis].

The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases

Pediatric bacterial meningitis and meningococcal disease profile in a Brazilian General Hospital.

Surveillance system assessment in Guinea: Training needed to strengthen data quality and analysis, 2016.

Sudanese journal of paediatrics

COVID-19 and lessons learned from the pandemic wave of meningococcal meningitis (1985-1990).

Recurrent meningococcal meningitis with complement 6 (C6) deficiency: A case report.

Medicine

Meningococcal infections among refugees and immigrants: silent threats of past, present and future.

Cuban Meningococcal Vaccine VA-MENGOC-BC:30 Years of Use and Future Potential.

MEDICC review

Characteristics and outcome of spontaneous bacterial meningitis in patients with diabetes mellitus.

The Origin of the Idea That Herpes Labialis Is of Prognostic Importance in Bacterial Meningitis.

European neurology

An assessment of the use of Hepatitis B Virus core protein virus-like particles to display heterologous antigens from Neisseria meningitidis.

Neurologia i neurochirurgia polska

Cerebrospinal meningitis: a global disease with regional variability?

Health workers' perceptions and challenges in implementing meningococcal serogroup a conjugate vaccine in the routine childhood immunization schedule in Burkina Faso.

BMC public health

Neurologia i neurochirurgia polska

Differences in the courses of meningococcal and pneumococcal cerebrospinal meningitis.

Journal of clinical microbiology

Validation of a New Rapid Detection Test for Detection of Neisseria meningitidis A/C/W/X/Y Antigens in Cerebrospinal Fluid.

Journal of visualized experiments : JoVE

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery.

MenAfriNet: A Network Supporting Case-Based Meningitis Surveillance and Vaccine Evaluation in the Meningitis Belt of Africa.

Meningococcal Meningitis Outbreaks in the African Meningitis Belt After Meningococcal Serogroup A Conjugate Vaccine Introduction, 2011-2017.

Spatiotemporal Analysis of Serogroup C Meningococcal Meningitis Spread in Niger and Nigeria and Implications for Epidemic Response.

Evaluation of the Impact of Meningococcal Serogroup A Conjugate Vaccine Introduction on Second-Year-of-Life Vaccination Coverage in Burkina Faso.

Bacterial Meningitis Epidemiology in Five Countries in the Meningitis Belt of Sub-Saharan Africa, 2015-2017.

Epidemiology of Bacterial Meningitis in the Nine Years Since Meningococcal Serogroup A Conjugate Vaccine Introduction, Niger, 2010-2018.

Neisseria meningitidis Serogroup W Meningitis Epidemic in Togo, 2016.

A case report of multiple cerebral abscess formation complicating serogroup B Neisseria meningitidis meningitis.

Archives of disease in childhood

Subdural and subarachnoid empyema as a complication of an acute meningococcal meningitis.

The Lancet. Infectious diseases

Cerebrospinal meningitis: lessons learnt from Africa.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Changes in the Molecular Epidemiology of Pediatric Bacterial Meningitis in Senegal After Pneumococcal Conjugate Vaccine Introduction.

Meningococcal pneumonia: a review.

Pneumonia (Nathan Qld.)

Gauging the epidemic potential of a widely circulating non-invasive meningococcal strain in Africa.

Microbial genomics

Archives of disease in childhood

Aseptic meningitis associated with routine infant immunisation visits that include the group B meningococcal vaccine, 4CMenB.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

Development a multi-epitope driven subunit vaccine for immune response reinforcement against Serogroup B of Neisseria meningitidis using comprehensive immunoinformatics approaches.

International journal of environmental research and public health

A Systematic Review for Vaccine-Preventable Diseases on Ships: Evidence for Cross-Border Transmission and for Pre-Employment Immunization Need.

Current opinion in infectious diseases

Meningitis vaccines in children: what have we achieved and where next?

Carbohydrates in Vaccine Development.

Current drug delivery

Neisseria meningitidis and cytomegalovirus simultaneous detection in the filmarray meningitis/encephalitis panel and its clinical relevance.

IDCases

Frontiers in microbiology

Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells as a Cellular Model to Study Neisseria meningitidis Infection.

A case of a FilmArray® ME false negative in meningococcal meningitis.

The Journal of infection

Revista panamericana de salud publica = Pan American journal of public health

[Genotypes of Neisseria meningitidis isolates in patients with meningococcal meningitis in Paraguay, 1996-2015Genótipos de Neisseria meningitidis isolados de pacientes com doença meningocócica no Paraguai, 1996-2015].

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Epidemiological burden of meningococcal disease in Latin America: A systematic literature review.

2018

Seasonal upsurge of pneumococcal meningitis in the Central African Republic.

Wellcome open research

Case fatality rates of invasive meningococcal disease by serogroup and age: A systematic review and meta-analysis.

Outbreaks of meningococcal meningitis in non-African countries over the last 50 years: a systematic review.

Journal of global health

Meningococcal strain evolution, dusty dry air and respiratory tract infections: An explosive relationship.

EBioMedicine

Meningococcal purpura fulminans and severe myocarditis with clinical meningitis but no meningeal inflammation: a case report.

World journal of clinical cases

Fatal meningococcal meningitis in a 2-year-old child: A case report.

Meningococcal Meningitis.

JAMA

PLoS neglected tropical diseases

Analysis of a meningococcal meningitis outbreak in Niger - potential effectiveness of reactive prophylaxis.

2018

Analysis of Death and Survival Factors Associated with Childhood Bacterial Meningitis at a Reference Pediatric Hospital in Antananarivo, Madagascar.

Journal of immunological sciences

Emerging infectious diseases

University-Based Outbreaks of Meningococcal Disease Caused by Serogroup B, United States, 2013-2018.

Journal of immunological sciences

Intraventricular empyema caused by Neisseria meningitidis.

IDCases

2018

Elimination of Epidemic Meningitis in the African Region: Progress and Challenges: 2010-2016.

Italian journal of pediatrics

Pediatric meningococcocal meningitis in the acute phase: how much does it cost?

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]

[Analysis of epidemic characteristics for meningococcal meningitis in China during 2015-2017].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]

[Efficacy, safety, and cost-effectiveness of meningococcal vaccines].

Ver todos os 825 no EuropePMC

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