Um distúrbio que envolve uma quantidade excessiva de gordura corporal.
Introdução
O que você precisa saber de cara
Um distúrbio que envolve uma quantidade excessiva de gordura corporal.
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 35 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 87 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
16 genes identificados com associação a esta condição.
Receptor for hormone LEP/leptin (Probable) (PubMed:22405007). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitar
Cell membraneBasolateral cell membraneSecreted
Leptin receptor deficiency
A rare disease characterized by normal levels of serum leptin, hyperphagia and severe obesity from an early age. Additional features include alterations in immune function, and delayed puberty due to hypogonadotropic hypogonadism.
Cell surface proteoglycan that may bear heparan sulfate (By similarity). May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism
Cell membrane
Nucleotide pyrophosphatase that generates diphosphate (PPi) and functions in bone mineralization and soft tissue calcification by regulating pyrophosphate levels (By similarity). PPi inhibits bone mineralization and soft tissue calcification by binding to nascent hydroxyapatite crystals, thereby preventing further growth of these crystals (PubMed:11004006). Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP and UTP to their corresponding mono
Cell membraneBasolateral cell membraneSecreted
Ossification of the posterior longitudinal ligament of the spine
A calcification of the posterior longitudinal ligament of the spinal column, usually at the level of the cervical spine. Patients with OPLL frequently present with a severe myelopathy that can lead to tetraparesis.
Satiety factor closely associated with the actions of leptin and neuropeptide Y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. It promotes neuronal development and survival in vitro
Secreted
Signaling protein that functions as an antagonist of melanocyte-stimulating-hormone receptors MC3R and MC4R by precluding agonist-induced signaling, thereby inhibiting cAMP production within the hypothalamus and adrenal gland (PubMed:10371151, PubMed:11145747, PubMed:9311920, PubMed:9892020). Involved in the control of feeding behavior via the central melanocortin system (PubMed:15927146, PubMed:9311920). Has very low activity towards MC5R (PubMed:9311920, PubMed:9892020). Also promotes endocyto
SecretedGolgi apparatus lumen
Obesity
A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
Precursor of the appetite-regulating peptide ghrelin, including ghrelin-27 and ghrelin-28 Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR) (PubMed:10604470, PubMed:35027551). Induces the release of growth hormone from the pituitary (PubMed:10604470). Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR) (PubMed:10604470, Pub
Secreted
G protein-coupled receptor for catecholamines that couples to both G(s) and G(i) proteins, leading to either activation or inhibition of adenylate cyclase and cAMP-dependent pathway, respectively (PubMed:10188996, PubMed:2570461, PubMed:8641219). The rank order of potency for physiological agonists is norepinephrine > epinephrine (PubMed:10188996, PubMed:2570461, PubMed:8641219). Involved in the regulation of thermogenesis and lipolysis in brown and white adipose tissue, after coupling to G(s) p
Cell membrane
Putative transmembrane transporter that plays a role in mitochondrial metabolism via an as yet unclear mechanism (PubMed:21775425, PubMed:36114012). Originally, this mitochondrial protein was thought to act as a proton transmembrane transporter from the mitochondrial intermembrane space into the matrix, causing proton leaks through the inner mitochondrial membrane, thereby uncoupling mitochondrial membrane potential generation from ATP synthesis (PubMed:11171965, PubMed:12670931, PubMed:12734183
Mitochondrion inner membrane
Obesity
A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
G protein-coupled receptor that binds melanocyte-stimulating hormones (alpha- and beta-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor (PubMed:12646665, PubMed:14764818, PubMed:25163632, PubMed:32327598, PubMed:33858992, PubMed:8392067). Functions as a central component of the leptin-melanocortin pathway, which is essential for maintaining energy homeostasis (PubMed:32327598, PubMed:33858992). Upon activation, couples to G(s) protein, stimulating adenylate cyclase a
Cell membrane
Obesity
A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult
Nucleus
Precursor protein of pituitary hormones that are involved in diverse physiological processes, including the regulation of energy balance, stress response, immune function and skin pigmentation Functions as a ligand for the melanocortin receptors MC1R, MC2R, MC3R and MC5R (PubMed:8396929, PubMed:8463333, PubMed:8636348). Activation of MC1R increases melanogenesis in melanocytes found in the skin and hair (PubMed:9620771). Binding to MC2R stimulates the adrenal glands to secrete cortisol (PubMed:8
Secreted
Obesity
A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
Required for ciliation (PubMed:28428259, PubMed:28625565, PubMed:28659385). Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia (PubMed:28428259, PubMed:28625565). Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CV
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centrioleCytoplasm, cytoskeleton, spindle poleCytoplasm, cytoskeleton, cilium basal body
Morbid obesity and spermatogenic failure
An autosomal recessive morbid obesity syndrome characterized by hypertension, fatty liver disease, insulin resistance, and decreased sperm counts. Variable clinical manifestations are early coronary artery disease with myocardial infarction before 45 years of age, type II diabetes mellitus, and intellectual disability. Morbid obese individuals are defined as having a BMI greater than 40.
Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP
Cytoplasmic vesicle, secretory vesicle
Proprotein convertase 1 deficiency
Characterized by obesity, hypogonadism, hypoadrenalism, reactive hypoglycemia as well as marked small-intestinal absorptive dysfunction It is due to impaired processing of prohormones.
Transcriptional regulator that acts as a negative regulator of receptor-dependent signaling pathways (PubMed:22504882). Specifically inhibits transactivation of the nuclear receptor with which it interacts (PubMed:22504882). Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1 (PubMed:14752053). Essential component of the liver circadian clock which via its interaction wi
NucleusCytoplasm
Obesity
A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
Ligand-activated transcription factor that forms obligate heterodimers with the retinoic acid receptor and acts as a key regulator of biological processes, such as adipocyte differentiation, lipid metabolism, glucose homeostasis and beta-oxidation of fatty acids (PubMed:16150867, PubMed:20829347, PubMed:23525231, PubMed:8702406, PubMed:8706692, PubMed:9065481). Activated by lipid ligands: binds peroxisome proliferators, such as hypolipidemic drugs, and fatty acids, such as prostaglandin J2 metab
NucleusCytoplasm
Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (PubMed:15899045, PubMed:17344214, PubMed:19688109). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigeni
Secreted
Leptin deficiency
A rare disease characterized by low levels of serum leptin, severe hyperphagia and intractable obesity from an early age.
Variantes genéticas (ClinVar)
223 variantes patogênicas registradas no ClinVar.
Vias biológicas (Reactome)
49 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — NÃO RARA NA EUROPA: Obesidade não rara
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Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Pesquisa e ensaios clínicos
Nenhum ensaio clínico registrado para esta condição.
Publicações mais relevantes
Being overindebted and overweight in Switzerland - A largely unexplored association in an understudied population.
Research on overindebtedness in general and on the relationship between overindebtedness and being overweight or obese in particular is extremely rare or practically nonexistent although both phenomena have shown an increasing trend in recent years and are expected and found to be more prevalent among lower social classes and educational levels. However, no such study for Switzerland has ever been conducted until now. Survey data collected in 2019 from 219 overindebted adult clients of four official debt advisory centers in the Canton of Zurich were used and linked with a sample of 1,997 respondents of the Swiss Health Survey 2017 of the same age and canton of residence. The entire study population included a total of 2,216 adult individuals. Contingency tables with relative frequencies were calculated to study differences between the two subsamples. Furthermore, logistic and Poisson regression analyses were performed to calculate unadjusted and multiple-adjusted odds ratios and risk ratios as proxies and measures for the relative risk of being overweight or obese among overindebted people. The prevalence rates of being overweight and having a body mass index (BMI) of 25+ and particularly of being obese (BMI of 30+) were significantly higher among overindebted individuals (BMI ≥ 25: 46%, BMI ≥ 30: 15%) than predominantly non-overindebted people (BMI ≥ 25: 38%, BMI ≥ 30: 9%). Overindebtedness increased the odds or the relative risk for such unfavourable body weights by 20% to 36% (overweight) and by 59% to 70% (obesity) depending on the effect measure considered. This was found regardless of overindebted individuals' sex, age and educational level and independent of the fact that they have a comparably very low sense of control, feel lonely much more often and show much more often moderate to severe depressive symptoms. Measures of effect or association found were statistically significant at least for obesity, but smaller than expected and somewhat under- and simultaneously overestimated in view of the younger average age and the lower educational level of the overindebted individuals.
Generalized Pustular Psoriasis: Current Treatment and Innovative Therapies.
Generalized pustular psoriasis (GPP) is a rare, life-threatening auto-inflammatory disease driven by IL-36 pathway dysregulation leading to recurrent flares of widespread erythema, sterile pustules, and systemic symptoms. Real-world data on spesolimab - the first U.S. Food and Drug Administration (FDA)/European Medicines Agency (EMA)-approved GPP therapy - remains scarce, particularly outside Europe. We performed a retrospective case series with prospective follow-up (2010-2025) following Consensus-based Clinical Case Reporting (CARE) guidelines. Nine patients diagnosed according to European Rare and Severe Psoriasis Expert Network (ERASPEN) criteria by board-certified dermatologists were included. Data on demographics, triggers, clinical features, complications, and treatments were collected from electronic medical records. Nine patients (100%) aged 3-61 years, including five (55.6%) female patients, were included. Obesity was the most common comorbidity (n=6, 66.7%). Steroid withdrawal was the most common trigger (n=5, 55.6%). All patients presented with generalized erythema, sterile pustules, and pain; complications observed were acute respiratory distress syndrome (ARDS) in two patients (22.2%) and acute cholangitis in one patient (11.1%). Six flares required inpatient care. Spesolimab achieved 100% flare-free status at 12 months versus 50-75% recurrence with non-IL-36 agents. A tiered treatment algorithm was proposed, prioritizing rapid IL-36 blockade in severe flares. This largest Latin American GPP cohort reveals an earlier onset in pediatric patients and high complication rates. Spesolimab shows superior flare control, but access barriers persist. Standardized protocols and genetic studies in diverse populations are urgently needed.
Defining the external exposome of newborns from La Palma Island, Spain: characteristics of realistic mixtures and its role on Precision Public Health.
The exposome framework provides an integrative perspective to characterize real-life exposures beyond single-chemical assessments. However, evidence on perinatal exposomes in non-urban populations is limited, particularly regarding pollutant mixtures and their contribution to adverse birth outcomes. We conducted a population-based cross-sectional study including 471 neonates from La Palma (Spain). A total of 106 pollutants were quantified in cord blood using validated methods. Exposures encompassed essential elements, toxic metals, prioritized pollutants, emerging elements, organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), and polycyclic aromatic hydrocarbons (PAHs), grouped into seven categories. Statistical analyses included descriptive statistics, correlation matrices, principal component analysis (PCA), and network visualization, stratified by sex, birthweight, and maternal smoking. Essential elements (Se, Zn, Cu, Mn) were detected in all samples, whereas emerging rare earth elements showed lower prevalence. PCA highlighted distinct exposure profiles, with PAHs and OCPs explaining the highest variance. Maternal smoking strongly influenced clustering: small for gestational age neonates from smoking mothers displayed a specific mixture of PAHs, OCPs, low-chlorinated PCBs, and Pb, contrasting with neonates of appropriate or large for gestational age. Network analyses revealed four main pollutant clusters, diverging from the seven predefined chemical groups and reflecting real-world mixtures shaped by common sources. Emerging pollutants, including rare earth elements and metals from electronic waste, formed a separate cluster. Exposome-based approaches can characterize neonatal exposure mixtures, reveal modifiable patterns, and inform targeted interventions within Precision Public Health. These findings underscore the need to mitigate maternal smoking and address emerging contaminant exposures in perinatal populations.
Occupational determinants of Long COVID in the population-based COVICAT cohort.
Occupational factors affect SARS-CoV-2 infection risk, but the occupational factors associated with Long COVID (LC) are unknown. We aimed to address this issue using individual data in a population-based cohort. In the prospective COVICAT study, 2020-2023, Catalonia, Spain, we examined the association between occupational determinants and LC. Among subjects with previous SARS-CoV-2 infection, those employed in the pandemic and with occupational information were analysed. Different metrics, including four job-exposure matrices, were used to evaluate individual occupational risk factors for LC (postinfection symptoms ≥3 months). Poisson models were used to estimate adjusted risk ratios (RRs) and 95% CIs. Among 2054 workers (1308 women, 746 men) aged 40-69 years, 486 developed LC (23.7%). Workers in jobs at high COVID-19 risk according to all metrics including health/social care, education, retail, transport and security showed higher LC risk. The main drivers of increased risk were close contact with colleagues and the public (RR up to 1.50; 95% CI 1.18 to 1.91), no social distance at workplace (up to 1.46; 95% CI 1.16 to 1.84), rare or no use of facemask (1.41; 95% CI 1.09 to 1.83) and commute by public transport (1.58; 95% CI 1.20 to 2.08). Working on-site during the pandemic was also associated with a higher LC risk compared with teleworking (1.57; 95% CI 1.19 to 2.09). Individual non-occupational risk factors for LC included female sex, comorbidities, obesity, number and severity of acute infections; vaccination and older age were protective. In a population-based cohort, several occupational factors increased LC risk. Focused preventive strategies are warranted to avoid the associated public health burden. LC should be recognised and compensated as an occupational disease.
Exploring endometrial cancer in premenopausal women-A nationwide PremEnCa cohort study.
An increased incidence of endometrial cancer has been noted, especially in premenopausal women in countries with rapid socioeconomic transition. In one of the largest patient cohorts of women ≤50 years, with manually validated register data, we aim to examine the pattern of disease of endometrial cancer and to evaluate the prognosis according to tumor and patient characteristics, focusing on body mass index. This is a nationwide population-based study on women ≤50 years with endometrial cancer, 2010-2021, using data from Swedish registries complemented by the reviewing of medical records. Overall survival and disease-free survival were calculated by the Kaplan-Meier method and the log-rank test. Multivariable regression analyses were performed. Of the total endometrial cancer cohort, 797 (5%) patients were ≤50 years of age (the PremEnCa cohort) with 0.9% under 40 years of age. Women ≤50 years of age had a higher prevalence of stage IA and endometrioid histology than older women. Among women ≤50 years of age, 46% met the criteria for obesity. No associations between socioeconomic factors and stage at diagnosis were found. Notably, women with lower Body Mass Index <20, had a higher proportion of non-endometrioid histology and higher stage of disease at the time of diagnosis. Median follow-up time was 4.2 (IOR 1.9-5.4) years. The recurrence rate was 6.1% in the PremEnCa cohort during the follow-up period, and the 5-year overall survival was 94.6% (95% CI: 92.6-96.0) for endometrioid and 68.5% (95% CI: 51.1-80.8) for non-endometrioid endometrial cancer. Only 36 of the 74 deaths were caused by endometrial cancer. In adjusted analyses for disease-free survival, non-endometrioid histology and International Federation of Gynecology and Obstetrics (FIGO) stage were associated with worse prognosis. Endometrial cancer in premenopausal women is very rare and is associated with an excellent prognosis. Histology and FIGO stage were the strongest prognostic factors. Half of the deaths were due to other causes, which emphasizes the importance of focusing on general health aspects in this young endometrial cancer population.
Publicações recentes
Being overindebted and overweight in Switzerland - A largely unexplored association in an understudied population.
Effectiveness and safety of GLP-1 receptor agonists in craniopharyngioma patients with obesity: A multicentre real-world study.
The burden of obesity in primary care in Italy: Italian real-world overweight/obesity study (ITROS).
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📚 EuropePMCmostrando 151
Generalized Pustular Psoriasis: Current Treatment and Innovative Therapies.
CureusBeing overindebted and overweight in Switzerland - A largely unexplored association in an understudied population.
PloS oneDefining the external exposome of newborns from La Palma Island, Spain: characteristics of realistic mixtures and its role on Precision Public Health.
International journal of hygiene and environmental healthOccupational determinants of Long COVID in the population-based COVICAT cohort.
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Acta obstetricia et gynecologica ScandinavicaIdentification of ALK in Thinness.
CellImpact of the Definition of Metabolically Healthy Obesity on the Association with Incident Cardiovascular Disease.
Metabolic syndrome and related disordersImprinting disorders in children born after ART: a Nordic study from the CoNARTaS group.
Human reproduction (Oxford, England)Liver Phenotypes of European Adults Heterozygous or Homozygous for Pi∗Z Variant of AAT (Pi∗MZ vs Pi∗ZZ genotype) and Noncarriers.
GastroenterologyGenome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically characterised cohort☆.
Journal of hepatologyRare Variants in Genes Linked to Appetite Control and Hypothalamic Development in Early-Onset Severe Obesity.
Frontiers in endocrinologyCalciphylaxis epidemiology, risk factors, treatment and survival among French chronic kidney disease patients: a case-control study.
BMC nephrologyIncidence of diabetes mellitus in Spain as results of the nation-wide cohort [email protected] study.
Scientific reportsPerinatal features of Prader-Willi syndrome: a Chinese cohort of 134 patients.
Orphanet journal of rare diseasesEuropean lipodystrophy registry: background and structure.
Orphanet journal of rare diseasesReducing the Clinical and Public Health Burden of Familial Hypercholesterolemia: A Global Call to Action.
JAMA cardiologyObesity and other medical comorbidities among NT1 patients after the Norwegian H1N1 influenza epidemic and vaccination campaign.
SleepCauses of death in Prader-Willi syndrome: lessons from 11 years' experience of a national reference center.
Orphanet journal of rare diseasesClinical Situation, Therapy, and Follow-Up of Adult Craniopharyngioma.
The Journal of clinical endocrinology and metabolismBreakthrough bloodstream infections in critically ill non-neutropenic patients: higher incidence and better survival than non-breakthrough infections.
Journal of medical microbiologyA retrospective analysis of the prevalence of imprinting disorders in Estonia from 1998 to 2016.
European journal of human genetics : EJHGFamilial Urinary Bladder Cancer with Other Cancers.
European urology oncologyParental support in promoting children's health behaviours and preventing overweight and obesity - a long-term follow-up of the cluster-randomised healthy school start study II trial.
BMC pediatrics[Children with psoriasis in secondary care: Clinical aspects and comorbidities diverge from the generally published data].
Annales de dermatologie et de venereologieTNF-α G-308A genetic variants, serum CRP-hs concentration and DNA damage in obese women.
Molecular biology reports[Prevalence of insomnia and characteristic of patients with insomnia in a health area of Majorca (Spain)].
Atencion primariaEvaluation of a rare glucose-dependent insulinotropic polypeptide receptor variant in a patient with diabetes.
Diabetes, obesity & metabolismHigh frequency of pathogenic and rare sequence variants in diabetes-related genes among Russian patients with diabetes in pregnancy.
Acta diabetologicaReoperations After Bariatric Surgery in 26 Years of Follow-up of the Swedish Obese Subjects Study.
JAMA surgeryPerioperative surgery- and anaesthesia-related risks of laparoscopic Roux-en-Y gastric bypass - a single centre, retrospective data analysis.
BMC anesthesiologyMelatonin in type 2 diabetes mellitus and obesity.
Nature reviews. EndocrinologyRisk factors associated with non-union after triple pelvic osteotomy (Toennis and Kalchschmidt technique): a case-control study and review of the literature.
Archives of orthopaedic and trauma surgeryEfficacy, safety, and tolerability of evolocumab in pediatric patients with heterozygous familial hypercholesterolemia: Rationale and design of the HAUSER-RCT study.
Journal of clinical lipidologyTreatment adherence and BMI reduction are key predictors of HbA1c 1 year after diagnosis of childhood type 2 diabetes in the United Kingdom.
Pediatric diabetesRare, potentially pathogenic variants in 21 keratoconus candidate genes are not enriched in cases in a large Australian cohort of European descent.
PloS oneCase Report: Identification of an HNF1B p.Arg527Gln mutation in a Maltese patient with atypical early onset diabetes and diabetic nephropathy.
BMC endocrine disordersAnalysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease.
Nature communicationsEffects of Gene Variants Controlling Vitamin D Metabolism and Serum Levels on Hepatic Steatosis.
DigestionIdentification of seven novel loci associated with amino acid levels using single-variant and gene-based tests in 8545 Finnish men from the METSIM study.
Human molecular geneticsSociodemographic and lifestyle determinants of non-attendance for cervical cancer screening in Lithuania, 2006-2014.
Public healthLoss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes.
Nature geneticsExome sequence analysis and follow up genotyping implicates rare ULK1 variants to be involved in susceptibility to schizophrenia.
Annals of human geneticsCharacteristics of a nationwide cohort of patients presenting with isolated hypogonadotropic hypogonadism (IHH).
European journal of endocrinologyNonalcoholic Fatty Liver Disease in Italian Children with Down Syndrome: Prevalence and Correlation with Obesity-Related Features.
The Journal of pediatricsHistopathological features of post-mortem pituitaries: A retrospective analysis.
Revista da Associacao Medica Brasileira (1992)Prevalence of diabetes mellitus and impaired glucose metabolism in the adult population of the Basque Country, Spain.
Diabetic medicine : a journal of the British Diabetic AssociationIs there still room for additional common susceptibility alleles for venous thromboembolism?
Journal of thrombosis and haemostasis : JTHSafety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial.
The Lancet. NeurologySocial/economic costs and health-related quality of life in patients with Prader-Willi syndrome in Europe.
The European journal of health economics : HEPAC : health economics in prevention and careVariants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan.
Nature communicationsPromotion of physical activity in patients with non-communicable diseases in Luxembourg: a follow-up of the Sport-Sante inventory from 2014.
Bulletin de la Societe des sciences medicales du Grand-Duche de LuxembourgIncidence of new-onset wheeze: a prospective study in a large middle-aged general population.
BMC pulmonary medicineUpdated results of 100 patients on clinical features and therapeutic options in necrobiosis lipoidica in a retrospective multicentre study.
European journal of dermatology : EJDCraniopharyngioma: long-term consequences of a chronic disease.
Expert review of neurotherapeuticsManagement of Takotsubo cardiomyopathy in non-academic hospitals in France: The Observational French SyndromEs of TakoTsubo (OFSETT) study.
Archives of cardiovascular diseasesDNA methylation and gene expression patterns in adipose tissue differ significantly within young adult monozygotic BMI-discordant twin pairs.
International journal of obesity (2005)Presentation and surgical management of leaks after mini-gastric bypass for morbid obesity.
Surgery for obesity and related diseases : official journal of the American Society for Bariatric SurgeryNut consumption is inversely associated with both cancer and total mortality in a Mediterranean population: prospective results from the Moli-sani study.
The British journal of nutritionThe prevalence of melanocortin-4 receptor gene mutations in Slovak obese children and adolescents.
Journal of pediatric endocrinology & metabolism : JPEMGenetic and structural variation in the SH2B1 gene in the Belgian population.
Molecular genetics and metabolismCopy number variations and cognitive phenotypes in unselected populations.
JAMATM6SF2 Glu167Lys polymorphism is associated with low levels of LDL-cholesterol and increased liver injury in obese children.
Pediatric obesityClinical Outcome, Hormonal Status, Gonadotrope Axis, and Testicular Function in 219 Adult Men Born With Classic 21-Hydroxylase Deficiency. A French National Survey.
The Journal of clinical endocrinology and metabolismPrimary prevention of congenital anomalies: recommendable, feasible and achievable.
Public health genomicsLongitudinal weight differences, gene expression and blood biomarkers in BMI-discordant identical twins.
International journal of obesity (2005)Maternal and birth anthropometric characteristics in relation to the risk of childhood lymphomas: a Swedish nationwide cohort study.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)Associações
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Being overindebted and overweight in Switzerland - A largely unexplored association in an understudied population.
- Generalized Pustular Psoriasis: Current Treatment and Innovative Therapies.
- Defining the external exposome of newborns from La Palma Island, Spain: characteristics of realistic mixtures and its role on Precision Public Health.
- Occupational determinants of Long COVID in the population-based COVICAT cohort.
- Exploring endometrial cancer in premenopausal women-A nationwide PremEnCa cohort study.
- Effectiveness and safety of GLP-1 receptor agonists in craniopharyngioma patients with obesity: A multicentre real-world study.
- The burden of obesity in primary care in Italy: Italian real-world overweight/obesity study (ITROS).
- Characterization of prevalent genetic variants in the Estonian Biobank body-mass index GWAS.
- Outcomes of inflammatory bowel disease in patients with obesity following bariatric surgery: propensity score-matched cohort study.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:521399(Orphanet)
- MONDO:0011122(MONDO)
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
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