Raras
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Neuralgia do trigêmeo
ORPHA:221091CID-10 · G50.0CID-11 · 8B82.0OMIM 190400DOENÇA RARA

A neuralgia do trigêmeo é um distúrbio nervoso que causa dor tipo facada ou choque elétrico em partes do rosto. A dor dura de alguns segundos a alguns minutos e geralmente ocorre em apenas um lado do rosto. Também pode causar espasmos musculares no rosto ao mesmo tempo que a dor. A dor pode resultar da pressão de um vaso sanguíneo contra o nervo trigêmeo (o nervo que transporta a dor, a sensação e outras sensações do cérebro para a pele do rosto), como uma complicação da esclerose múltipla ou devido à compressão do nervo por um tumor ou cisto. Em alguns casos, a causa é desconhecida. As opções de tratamento incluem medicamentos, cirurgia e abordagens complementares.

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Introdução

O que você precisa saber de cara

📋

A neuralgia do trigêmeo é um distúrbio nervoso que causa dor tipo facada ou choque elétrico em partes do rosto. A dor dura de alguns segundos a alguns minutos e geralmente ocorre em apenas um lado do rosto. Também pode causar espasmos musculares no rosto ao mesmo tempo que a dor. A dor pode resultar da pressão de um vaso sanguíneo contra o nervo trigêmeo (o nervo que transporta a dor, a sensação e outras sensações do cérebro para a pele do rosto), como uma complicação da esclerose múltipla ou devido à compressão do nervo por um tumor ou cisto. Em alguns casos, a causa é desconhecida. As opções de tratamento incluem medicamentos, cirurgia e abordagens complementares.

Pesquisas ativas
38 ensaios
137 total registrados no ClinicalTrials.gov
Publicações científicas
8.795 artigos
Último publicado: 2026 Apr 16

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
Unknown
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Worldwide
Início
Adolescent
+ adult, elderly
🏥
SUS: Cobertura mínimaScore: 15%
CID-10: G50.0
🇧🇷Dados SUS / DATASUS
PROCEDIMENTOS SIGTAP (2)
0202010694
Sequenciamento completo do exoma (WES)genetic_test
0301070040
Atendimento em reabilitação — doenças rarasrehabilitation
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Entender a doença

Do básico ao detalhe, leia no seu ritmo

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Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🧠
Neurológico
2 sintomas
😀
Face
1 sintomas
📏
Crescimento
1 sintomas
❤️
Coração
1 sintomas
💪
Músculos
1 sintomas

+ 12 sintomas em outras categorias

Características mais comuns

100%prev.
Neuralgia trigeminal
90%prev.
Alodinia
Muito frequente (99-80%)
90%prev.
Depressão
Muito frequente (99-80%)
90%prev.
Cefaleia em salvas
Muito frequente (99-80%)
55%prev.
Disfunção somatossensorial
Frequente (79-30%)
55%prev.
Dor mandibular
Frequente (79-30%)
18sintomas
Muito frequente (4)
Frequente (8)
Ocasional (5)
Sem dados (1)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 18 características clínicas mais associadas, ordenadas por frequência.

Neuralgia trigeminalTrigeminal neuralgia
Muito frequente100%
AlodiniaAllodynia
Muito frequente (99-80%)90%
DepressãoDepression
Muito frequente (99-80%)90%
Cefaleia em salvasCluster headache
Muito frequente (99-80%)90%
Disfunção somatossensorialSomatic sensory dysfunction
Frequente (79-30%)55%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico8.795PubMed
Últimos 10 anos200publicações
Pico2026122 papers
Linha do tempo
2026Hoje · 2026🧪 1997Primeiro ensaio clínico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
Aprovado1
2Fase 21
1Fase 13
·Pré-clínico15
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 20 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Neuralgia do trigêmeo

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

🟢 Recrutando agora

20 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

NCT06949436 · Ultra-Early Gamma Knife Stereotactic Radiosurgery for TNRecrutando
PHASE2
NCT06724029 · Neurosurgical Outcome NetworkRecrutando
NCT02910323 · The Will Erwin Headache Research Center - Cluster Headache S…Recrutando
NCT06216886 · OnabotulinumtoxinA for Trigeminal NeuralgiaRecrutando
PHASE4
NCT05738096 · Trigeminal Evoked Responses to Improve RhizotomyRecrutando
EARLY_PHASE1
NCT05269472 · Trigeminal Neuralgia ElectrophysiologyRecrutando
NCT06290661 · Clinical Trial of the Safety and Efficacy of Peripheral Nerv…Recrutando
NA
NCT06213155 · A Study to Investigate the Efficacy of Pain Reduction With C…Recrutando
NA
NCT05051072 · Assessment in Patients With Essential Trigeminal Neuralgia o…Recrutando
NA
NCT06851910 · Intravenous Lacosamide for the Treatment of Acute Pain in Tr…Recrutando
NCT06890897 · Esketamine Combined Pulsed Radiofrequency for Acute/Subacute…Recrutando
NA
NCT05152368 · Safety of Cultured Allogeneic Adult Umbilical Cord Stem Cell…Recrutando
PHASE1
NCT06863324 · Impact of Individual Radiosensitivity on Late Toxicities of …Recrutando
NA
NCT06472323 · The Efficacy and Safety of Pulsed Radiofrequency Combined Wi…Recrutando
NCT06278194 · Masseter Muscle Thickness in Gasser Ganglion Radiofrequency …Recrutando
NA
NCT05677243 · Observational Study on the Treatment of Trigeminal Neuralgia…Recrutando
NCT06779578 · Fluoroscopic-Guided Bipolar Versus Monopolar Pulsed Radiofre…Recrutando
NA
NCT06684275 · Comparison of Pulsed and Thermal Radiofrequency for Trigemin…Recrutando
NA
NCT05451251 · Deep Brain Stimulation for Refractory Trigeminal Neuralgia w…Recrutando
PHASE1
NCT06620172 · CT-guided vs Fluoroscopy-guided Trigeminal Ganglion Radiofre…Recrutando
NA

Outros ensaios clínicos

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Publicações mais relevantes

Timeline de publicações
3.868 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 3.868

#1

A Tac1-Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)2026 Mar 13

Este estudo inovador desvenda a patogénese da neuralgia trigeminal (NT), uma dor severa e pouco compreendida, ao identificar uma via neural específica no cérebro (TG-Sp5CTac1-PBNTac1) que impulsiona o seu desenvolvimento. A inibição de neurónios específicos nesta via ou a redução do gene Tachykinin 1 (Tac1) demonstrou prevenir ou atenuar significativamente a dor, oferecendo novos e promissores alvos para o desenvolvimento de tratamentos mais eficazes para pacientes e médicos.

🇧🇷 traduzido
#2

Retrospective evaluation of treatment outcomes of Gasserian ganglion radiofrequency thermocoagulation in trigeminal neuralgia patients with multiple sclerosis.

Turkish journal of medical sciences2026

Este estudo retrospectivo avaliou a eficácia e segurança da termocoagulação e radiofrequência pulsada do gânglio de Gasser em 12 pacientes com neuralgia do trigêmeo (NT) secundária à esclerose múltipla (EM), uma condição rara e debilitante. Os resultados foram promissores: todos os pacientes relataram mais de 50% de alívio da dor em seis meses, com 75% mantendo o benefício em 12 meses, e o tratamento foi bem tolerado, sem complicações significativas. Embora represente uma das maiores séries de casos sobre esta técnica em pacientes com EM, os autores ressaltam a necessidade de estudos futuros com amostras maiores para validar plenamente essas descobertas encorajadoras para pacientes e médicos.

🇧🇷 traduzido
#3

Internal neurolysis for atypical facial pain: Clinical outcomes and validation of an intraoperative trigeminal pathology scoring system.

Surgical neurology international2026

Este estudo avaliou a neurólise interna (IN) como um tratamento eficaz e seguro para a dor facial atípica (DFA), uma condição que difere da neuralgia do trigêmeo típica. A pesquisa demonstrou que 75% dos pacientes com DFA obtiveram alívio significativo da dor com a IN, sem complicações maiores. Para médicos, o estudo ressalta que, ao contrário da neuralgia típica que muitas vezes se resolve com descompressão vascular, a DFA frequentemente requer dissecção e neurólise interna, especialmente em pacientes com esclerose do nervo trigêmeo, destacando estratégias de tratamento distintas.

🇧🇷 traduzido
#4

Neuropsychiatric Disorders and Constipation: Unraveling Causal Links Through Genetic Analysis.

Brain and behavior2026 Mar

Uma análise genética recente, utilizando randomização mendeliana, revelou que ansiedade e depressão podem aumentar o risco de constipação. Inversamente, a constipação eleva o risco de ansiedade, depressão e, de forma significativa, **quase dobra o risco de desenvolver neuralgia do trigêmeo** (OR = 1.897). Para pacientes e médicos, este achado enfatiza a importância de identificar e gerenciar proativamente os sintomas de constipação em indivíduos com condições neuropsiquiátricas, incluindo a neuralgia do trigêmeo, visando melhorar sua saúde e qualidade de vida.

🇧🇷 traduzido
#5

A case of myelin oligodendrocyte glycoprotein antibody-associated disease presenting with radiculopathies.

Rinsho shinkeigaku = Clinical neurology2026 Feb 13

Este artigo é relevante para pacientes e médicos porque destaca que a neuralgia do trigêmeo pode ser uma manifestação da doença MOGAD, uma condição desmielinizante que afeta não só o sistema nervoso central, mas também o periférico. Para um diagnóstico preciso, é crucial considerar a pesquisa de anticorpos MOG no líquor (CSF) em casos de forte suspeita clínica ou envolvimento misto (central e periférico), mesmo que os testes sanguíneos (soro) sejam negativos.

🇧🇷 traduzido

Publicações recentes

Ver todas no PubMed

📚 EuropePMC5.898 artigos no totalmostrando 194

2026

Early glucocorticoid therapy for brainstem edema associated with acute inflammatory Teflon granuloma after microvascular decompression for trigeminal neuralgia: illustrative case.

Journal of neurosurgery. Case lessons
2026

Influence of Neurovascular Conflict on the Outcome of Primary Gamma Knife Radiosurgery for Trigeminal Neuralgia: A Single-Center Retrospective Study.

Stereotactic and functional neurosurgery
2026

A Novel Mobile C-Arm Fluoroscopic Imaging of the Foramen Ovale and Its Anatomical Principles.

Journal of pain research
2026

Successful treatment of neuropathic symptoms in acute trigeminal herpes zoster with high-dose intravenous ascorbic acid: A two-case report.

Explore (New York, N.Y.)
2026

How I do it: identification and preservation of trigeminocerebellar artery from superior petrosal vein during endoscopic microvascular decompression for trigeminal neuralgia.

Acta neurochirurgica
2026

Evaluation of trigeminal nerve microvascular decompression with sensory root neurolysis.

Pain management
2026

Development of an Expert Consensus on Electroacupuncture for Trigeminal Neuralgia Using the Delphi Method: A Study Protocol.

Journal of pain research
2026

Evaluation of Watson constraints in Gamma Knife stereotactic radiosurgery for medically intractable trigeminal neuralgia in the era of preplanning MRI with frame-based cone beam CT treatment.

Clinical neurology and neurosurgery
2026

Phosphoproteomics uncovers a neuroimmune perspective on trigeminal neuralgia: sexually dimorphic regulatory networks linking calcium channels to the complement cascade.

Frontiers in immunology
2026

A comprehensive evaluation of non-vascular prepontine cistern anatomy influencing trigeminal nerve vulnerability using machine learning-based morphometric analysis.

Frontiers in medicine
2026

The Mind Locker Method: A Lived-Experience Model of Chronic Pain Self-Regulation and Resilience.

Qualitative health research
2026

Historical evolution of microvascular decompression after Jannetta's establishment: Anatomical maps and physiological compasses-a narrative review.

Acta neurochirurgica
2026

Temporalis Muscle-Originated Supraorbital Neuralgia Misdiagnosed as Trigeminal Neuralgia.

The Journal of craniofacial surgery
2026

Machine learning-based quantification of neurovascular compression for correlation with trigeminal neuralgia pain outcomes.

Pain
2026

Dexmedetomidine Use and Intraoperative Bradycardia During Radiofrequency Rhizotomy for Trigeminal Neuralgia: A Retrospective Observational Study.

Drug design, development and therapy
2026

Hemodynamic parameters as biomarkers for predicting microvascular decompression efficacy in classic trigeminal neuralgia.

Journal of neurosurgery
2026

A Tac1-Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
2026

Vertically Crowded Small Posterior Fossa Is a Possible Cause of Trigeminal Neuralgia in Young Adults: Operative Nuances of Microvascular Decompression Based on Associated Morphological Features.

Operative neurosurgery (Hagerstown, Md.)
2026

Efficacy and Safety of Repeated Radiofrequency Thermocoagulation on Trigeminal Neuralgia Patients.

Pain practice : the official journal of World Institute of Pain
2026

A Diagnostic Pitfall: Carbamazepine-Induced Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome Masquerading As Angiotensin-Converting Enzyme Inhibitor Angioedema.

Cureus
2026

Retrospective evaluation of treatment outcomes of Gasserian ganglion radiofrequency thermocoagulation in trigeminal neuralgia patients with multiple sclerosis.

Turkish journal of medical sciences
2026

A case of trigeminal nerve neurosarcoidosis initially presenting with isolated neurological findings mimicking trigeminal schwannoma: a case report and review of the literature.

Journal of medical case reports
2026

Pitfalls in Trigeminal Nerve Mapping in Neurosurgery: The Mystery of the Unexpected Motor Responses.

Journal of neurological surgery. Part B, Skull base
2026

Mini-invasive Anterior Petrosal Intertentorial Approach for Trigeminal Neuralgia: Rationale and Limits of the Technique.

Journal of neurological surgery. Part B, Skull base
2026

Individualized rs-fMRI reveals brain-circuit heterogeneity and predicts early recurrence in trigeminal neuralgia.

Frontiers in psychiatry
2026

Exploring the Molecular Mechanism of Shaoyao Gancao Decoction for Trigeminal Neuralgia Based on Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation.

ACS omega
2026

From microvascular decompression to radiosurgery: a network meta-analysis of interventions for medication-refractory trigeminal neuralgia.

Neurosurgical review
2026

Predictive value of preoperative white and gray matter microstructural alterations for microvascular decompression outcome in classical trigeminal neuralgia.

Cephalalgia : an international journal of headache
2026

Internal neurolysis for atypical facial pain: Clinical outcomes and validation of an intraoperative trigeminal pathology scoring system.

Surgical neurology international
2026

Neuropsychiatric Disorders and Constipation: Unraveling Causal Links Through Genetic Analysis.

Brain and behavior
2026

Trigeminal nerve transposition by sling-pulling technique in combination with macrovascular transposition for giant basilar artery-induced trigeminal neuralgia via a combined transpetrosal approach.

Acta neurochirurgica
2026

The ethyl acetate extract of Schefflera kwangsiensis ameliorates oxaliplatin-induced peripheral neuropathic pain via SERCA2b.

Chinese journal of natural medicines
2026

Computed Tomography-Guided Short-Term Gasserian Ganglion Stimulation for the Treatment of Idiopathic Trigeminal Neuralgia: A Two-Case Report.

Pain medicine case reports
2025

Muscle Versus Teflon as Interposition Grafts in Microvascular Decompression for Primary Trigeminal Neuralgia: Institutional Series, Systematic Review, and Meta-Analysis.

Operative neurosurgery (Hagerstown, Md.)
2026

Investigation of miRNAs affecting schwann cells in patients with trigeminal neuralgia.

Molecular biology reports
2026

Advanced, pharmacological and complementary interventions for chronic or recurrent orofacial pain conditions: a systematic evidence map with selective meta-analyses.

The journal of headache and pain
2026

Outcomes of microvascular decompression for trigeminal neuralgia: a retrospective analysis from a Mexican high-specialty center.

Arquivos de neuro-psiquiatria
2026

A Comprehensive Mendelian Randomization Study of Bidirectional Causal Relationships Between Pain and Mental Disorders.

Journal of pain research
2026

Classification of solitary pontine lesion-related trigeminal neuralgia.

Cephalalgia : an international journal of headache
2026

Recognizing solitary pontine lesion-related trigeminal neuralgia as a distinct entity: The need for an updated ICHD classification.

Cephalalgia : an international journal of headache
2026

On the topical issue of assisted dying: the insurmountable challenges of human existence, and the right to exit.

Frontiers in public health
2026

Fixel‑based analysis reveals distributed white matter alterations associated with pain severity in trigeminal neuralgia.

The journal of headache and pain
2026

Early Postoperative Hypesthesia after Microvascular Decompression for Trigeminal Neuralgia is a Predictor of Long-Term Pain Relief: A Long-Term Cohort Study.

World neurosurgery
2026

Trigeminal neuralgia: why beautiful images don't always make the diagnosis.

European radiology
2026

Anticonvulsant Therapy in Trigeminal Neuralgia: A Class-Oriented Systematic Review.

Medicines (Basel, Switzerland)
2026

Pain in multiple sclerosis: clinical phenotypes and therapeutic strategies - a narrative review.

Pain reports
2026

Nr4a1 regulates microglia overactivation-mediated neuroinflammation to ameliorate cognitive impairment in trigeminal neuralgia rats.

The journal of headache and pain
2026

Linear Accelerator Mask-Based Radiosurgery for Trigeminal Neuralgia: Prospective Evaluation of 50 Patients.

World neurosurgery
2026

Partial sensory rhizotomy in therapy-refractory and recurrent trigeminal neuralgia - a single center experience.

Acta neurochirurgica
2026

Keyhole retrosigmoid approach for microvascular decompression surgery: systematic review and single-arm meta-analysis.

Neurosurgical review
2026

Experience and Efficacy Evaluation of Microvascular Decompression and Selective Nerve Root Dissection in the Treatment of Trigeminal Neuralgia Combined With Glossopharyngeal Neuralgia.

The Journal of craniofacial surgery
2025

Trigeminal somatosensory evoked potentials for intraoperative monitoring and prognostic prediction in microvascular decompression for trigeminal neuralgia: a prospective cohort study.

Frontiers in neurology
2026

A case of myelin oligodendrocyte glycoprotein antibody-associated disease presenting with radiculopathies.

Rinsho shinkeigaku = Clinical neurology
2026

Efficacy and safety of percutaneous balloon compression for trigeminal neuralgia associated with multiple sclerosis: A systematic review and meta-analysis.

Multiple sclerosis and related disorders
2026

The utility of partial sensory rhizotomy and adjunct procedures in the surgical management of trigeminal neuralgia secondary to multiple sclerosis.

Journal of neurosurgery
2026

Photobiomodulation Therapy in the Management of Orofacial Neuropathic Pain-WALT Position Paper 2026.

Journal of clinical medicine
2026

Preneurosurgical Care for Patients With Trigeminal Neuralgia.

JAMA network open
2026

Hydrocephalus-associated trigeminal neuralgia.

Frontiers in neurology
2026

[Posterior petrous meningiomas: clinical manifestations, anatomical relationships and postoperative outcomes].

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko
2026

Glymphatic dysfunction in trigeminal neuralgia: A multimodal MRI study.

Neurobiology of disease
2026

Diagnostic challenges of trigeminal neuralgia in dental settings: a retrospective study.

BMC neurology
2026

Radiofrequency Versus Percutaneous Balloon Compression for Trigeminal Neuralgia: A Systematic Review and Meta-Analysis.

World neurosurgery
2026

Double-faced microprobe for vessel transposition in microvascular decompression: technical note.

Acta neurochirurgica
2026

Pivotal Factors for Minimizing the Risks of Therapeutic Failure in Trigeminal Neuralgia and Hemifacial Spasm.

Current pain and headache reports
2026

Lateral Orbitotomy for Trigeminal Schwannomas: Surgical Technique, Outcomes, and Limitations.

Operative neurosurgery (Hagerstown, Md.)
2026

CyberKnife Stereotactic Radiosurgery for Vestibular Schwannomas: Systematic Review and Meta-Analysis of Long-Term Tumor Control and Hearing Preservation Outcomes.

Neurosurgery practice
2026

Short-term infraorbital nerve electrical stimulation for herpes zoster herpetic trigeminal maxillary division neuralgia: A case report.

Medicine
2026

Posterior circulation hypoperfusion plays an important role in refractory otalgia: case report.

BMC surgery
2026

Effectiveness of laser photobiomodulation in the management of trigeminal neuralgia: a systematic review and meta-analysis.

Lasers in medical science
2026

Trends, Insights, and Challenges in the Treatment of Trigeminal Neuralgia: A Bibliometric Analysis of The Top 200 Most Influential Articles.

Journal of neurological surgery. Part A, Central European neurosurgery
2026

Ventral Compression of the Trigeminal Nerve by the Superior Cerebellar Artery: A Novel Intraoperative Classification and Clinical Significance.

The Journal of craniofacial surgery
2026

Microvascular decompression of aberrantly looped anterior inferior cerebellar artery: illustrative case.

Journal of neurosurgery. Case lessons
2026

Selecting Neuromodulation Devices For Chronic Pain Conditions: A Narrative Review.

Pain physician
2026

Safety and Efficacy of Microvascular Decompression for Trigeminal Neuralgia in the Octogenarian Population: Insights From a Propensity Score-Adjusted and Matched Analysis.

Neurosurgery
2026

Shredded vs. pledget teflon in microvascular decompression for trigeminal neuralgia: a retrospective comparative study.

British journal of neurosurgery
2026

Clinical Characteristics and Treatment Resistance of Trigeminal Neuralgia in Multiple Sclerosis Patients: A Retrospective Observational Study.

Noro psikiyatri arsivi
2026

Comparison of Gasserian ganglion conventional radiofrequency ablation and peripheral nerve pulsed radiofrequency in trigeminal neuralgia: a retrospective cohort study.

Journal of oral &amp; facial pain and headache
2026

Causal association between multiple sclerosis and trigeminal neuralgia: A Mendelian randomization study with meta-analysis.

Cranio : the journal of craniomandibular practice
2026

Predictors of Postoperative Complications After Microvascular Decompression for Trigeminal Neuralgia and Hemifacial Spasm: A Retrospective Cohort Study.

The Journal of craniofacial surgery
2025

Repeat posterior fossa exploration and external neurolysis for recurrent trigeminal neuralgia following microvascular decompression.

Frontiers in surgery
2026

No Glymphatic Dysfunction in Trigeminal Neuralgia: A Preliminary Study.

Brain and behavior
2026

Risk Factors Associated with Dentofacial Anomalies [Including Malocclusion] in Adults.

Bioengineering (Basel, Switzerland)
2026

Ultrasound- and CT-Guided Medial-to-Lateral Radiofrequency Ablation of the Infraorbital Nerve for Persistent Idiopathic Dentoalveolar Pain: A Trajectory-Based Approach.

Diagnostics (Basel, Switzerland)
2026

When Cancer Mimics Pain: Maxillary Primary Intraosseous Carcinoma Misdiagnosed as Trigeminal Neuralgia.

Dentistry journal
2025

Current Practice Patterns in Microvascular Decompression for Trigeminal Neuralgia: Results From an International Survey in Central Europe.

Cureus
2026

Calretinin Contributes to Trigeminal Neuropathic Pain Downstream of Cavα2δ1.

ACS chemical neuroscience
2026

Rabies Virus Glycoprotein-Decorated Liposomes in Thermosensitive Nasal Spray Gels: Facilitating Retrograde Neural Transport for Targeted Trigeminal Neuralgia Therapy.

ACS nano
2026

Causal interplay between trigeminal neuralgia and systemic inflammatory markers: A bidirectional Mendelian randomization study.

Medicine
2026

The use of cellular therapies for trigeminal neuralgia: a systematic review of behavioral and molecular outcomes.

Neurosurgical review
2026

Comparative efficacy of microvascular decompression and radiofrequency rhizotomy in idiopathic trigeminal neuralgia with a neurovascular contact without root distortion.

British journal of neurosurgery
2025

Epidemiological and demographic patterns of pediatric trigeminal neuralgia: nationwide trends in diagnosis and treatment over a decade.

Journal of neurosurgery. Pediatrics
2025

Trigeminal neuralgia caused by a transfixed arterial loop: illustrative case.

Journal of neurosurgery. Case lessons
2026

Beyond the physical dose: implications of biologically effective dose variations in the stereotactic radiosurgical treatment of trigeminal neuralgia.

Journal of neurosurgery
2025

Low-intensity pulsed ultrasound ameliorates partial infraorbital nerve ligation-induced trigeminal neuropathic pain through inhibiting Schwann cell Pannexin 1 channel.

Frontiers in immunology
2026

Trigeminal neuralgia-like pain in a vagus nerve stimulation super-responder with drug-resistant idiopathic generalized epilepsy: A case report.

Epilepsy &amp; behavior reports
2026

Bovine pericardial patch in an eggroll fashion and teflon felt microvascular decompression for trigeminal neuralgia and hemifacial spasm: A retrospective study.

Medicine
2026

The Use of Botulinum Toxin Injections in Peripheral Neuropathic Pain: A Systematic Review of Efficacy and Safety Outcomes.

Pain research &amp; management
2026

Microvascular decompression for vertebrobasilar dolichoectasia-related primary trigeminal neuralgia: surgical approaches, technical considerations, and clinical outcomes.

Neurosurgical review
2026

Hippocampal myelin damage contributes to cognitive impairment in a rat model of trigeminal neuropathic pain: Neuroprotective and anti-inflammatory effects of atorvastatin.

Neuroscience research
2026

Predictive Model Development for Postoperative Complications in Trigeminal Neuralgia Patients Undergoing Percutaneous Balloon Compression.

World neurosurgery
2025

Gamma Knife-Mimicking Radiosurgery With Cyberknife: A Comparison of Dose Prescription Methodologies for the Treatment of Trigeminal Neuralgia.

Cureus
2026

BMP7 alleviates trigeminal neuralgia by suppressing oxidative stress and activation of satellite glial cells via the NRF2/HO-1 pathway.

Brain, behavior, and immunity
2026

Peripheral Nerve Stimulation Is Effective in the Management of Trigeminal Pain: A Systematic Review and meta-analysis.

Current pain and headache reports
2026

Electrophysiological monitoring of trigeminal nerve sensory root using sensory-masseter response for microvascular decompression in trigeminal neuralgia.

Acta neurochirurgica
2026

Subcortical neuroimaging signature of painful disorders of the trigeminal nerve: a UK Biobank study.

The journal of headache and pain
2026

Experimental Study of a Newly Developed Prosthesis and Its Initial Clinical Use in Microvascular Decompression Surgery.

Neurologia medico-chirurgica
2025

Severe Symptomatic Bradycardia Following First-Dose Oxcarbazepine in a Very Elderly Patient on Long-Term Carbamazepine: A Case Report.

Cureus
2026

Analysis of Risk Prediction Model for Recurrence of Trigeminal Neuralgia After Percutaneous Balloon Compression.

Pain research &amp; management
2026

Sphenopalatine ganglion block in orofacial pain and headache disorders: A review of case reports.

Cranio : the journal of craniomandibular practice
2026

Global Incidence and Prevalence of Trigeminal Neuralgia, 1945-2024: A Systematic Review and Meta-Regression Analysis.

Journal of clinical neurology (Seoul, Korea)
2026

Eight Decades of Data Reveal a Far Greater Global Burden of Trigeminal Neuralgia.

Journal of clinical neurology (Seoul, Korea)
2026

Lymphoma in Meckel cave mimicking trigeminal schwannoma - analysis of misdiagnosis causes and insights into imaging: Case report.

Medicine
2026

The Role of Biological Effective Dose in Gamma Knife Radiosurgery: A Systematic Review Across Multiple Indications.

Journal of clinical medicine
2026

Debunking myths in facial pain diagnosis for the pain practitioner.

Regional anesthesia and pain medicine
2026

Successful Radiosurgical Treatment of Trigeminal Neuralgia and Related Facial Pain Syndromes: The Australian Gamma Knife Experience.

Journal of medical imaging and radiation oncology
2026

Research Progress on Radiofrequency Treatment of Primary Trigeminal Neuralgia in the V2 Maxillary Nerve.

Pain and therapy
2025

Magnetic resonance imaging-based classification of trigeminal nerve-superior cerebellar artery relationships.

World journal of radiology
2026

TRPC6 mediates neuronal hyperexcitability in the lateral habenula to drive trigeminal neuralgia-associated anxiety.

Neuropharmacology
2025

Ultrasound-Identified Trigger-Point and Ultrasound-Guided IncobotulinumtoxinA (Xeomin®) Injection for Refractory V2-V3 Trigeminal Neuralgia: A Case Report.

Cureus
2025

Navigating Neurological Complications in Aesthetic Dermatology: Onset of Trigeminal Neuralgia Following Laser Hair Reduction.

Cureus
2025

Anaesthesia dolorosa after gamma knife radiosurgery: a cautionary insight into long-term complications.

BMJ case reports
2025

[Clinical study on improving the curative effect of acupuncture on primary trigeminal neuralgia by syndrome differentiation and treatment].

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
2025

Spigelia Anthelmia for Uterine Fibroid: Case Report of a Homeopathic Cure Guided by a Urinary Modality.

Homeopathy : the journal of the Faculty of Homeopathy
2025

Effects of risk factor-based targeted nursing intervention on psychological status, sleep quality, and pain in patients with trigeminal neuralgia.

Frontiers in neurology
2026

Treatment strategy in stereotactic radiosurgery for trigeminal neuralgia, essential tremor, and coexisting intracranial tumors: The impact of biologically effective dose on clinical outcome.

Journal of applied clinical medical physics
2025

Keeping It Simple: A Case Report on Atomized Intranasal 1% Lidocaine as an Effective Treatment for Pain Crisis Due to Trigeminal Neuralgia.

Cureus
2025

Cerebellar neurocan gene expression is a common pathogenic factor of trigeminal neuralgia and depression.

The journal of headache and pain
2025

Anatomical Variations of the Foramen Ovale and Trigeminal Neuralgia.

Cureus
2025

Treatment-Induced Diabetic Neuropathy: A Case Report on Multimodal Pain Management in a Young Patient With Type I Diabetes.

Cureus
2025

Updates on the Proposed Botulinum Toxin A Mechanisms of Action in Orofacial Pain: A Review of Animal Studies.

Toxins
2025

History and Development of Clinical Use of Functional Stereotaxy for Radiation Oncologists: From Its Origins to Its Current State.

Current oncology (Toronto, Ont.)
2025

Absence of Meckel's cave causing trigeminal neuralgia.

Acta neurologica Belgica
2025

Staged posterior fossa decompression and microvascular decompression for trigeminal neuralgia in autosomal dominant osteopetrosis type I: A case report.

Medicine
2025

A mouse model of classical trigeminal neuralgia via intradural compression of the trigeminal nerve.

The journal of headache and pain
2026

Antinociceptive role of IL-10/STAT3 signaling in trigeminal neuropathic pain male rat model through Pomc and β-endorphin.

Neuroscience letters
2025

Calcitonin gene-related peptide concentration in cerebrospinal fluid and serum in horses affected by trigeminal-mediated headshaking.

Equine veterinary journal
2025

USP19 restores mitochondrial function in neurons by deubiquitinating FUS to alleviate trigeminal neuralgia.

Experimental brain research
2025

[LIU Xing's experience in treatment of primary trigeminal neuralgia by the integration of acupuncture and medication].

Zhongguo zhen jiu = Chinese acupuncture &amp; moxibustion
2026

Radiation Therapy for Non-Malignant Central Nervous System Tumors, Disorders, and Illnesses - Current Applications and Future Directions.

Seminars in radiation oncology
2025

Aneurysm clip suspension-assisted microvascular decompression for trigeminal neuralgia: a case report and literature review.

BMC surgery
2025

A large-scale dataset of pre- and postsurgical MRI data from patients with chronic trigeminal neuralgia.

Scientific data
2025

Nursing of Computed Tomography-Guided Percutaneous Balloon Compression for Primary Trigeminal Neuralgia under Local Anesthesia and Intravenous Analgesia.

Pain management nursing : official journal of the American Society of Pain Management Nurses
2025

Microvascular decompression versus percutaneous balloon compression for trigeminal neuralgia: a systematic review and meta-analysis of double-arm studies.

Neurological research
2025

Facial Pain Mimicking Trigeminal Neuralgia Secondary to Low-Cervical Spondylosis: A Case Report and Comprehensive Literature Review.

Cureus
2025

Genetically predicted the causal relationship between gut-brain axis and chronic pain: a Mendelian randomization study.

Human genomics
2025

L3MBTL2 as a novel therapeutic target for trigeminal neuralgia: evidence from integrated TWAS, multi-tissue MR, and experimental validation.

The journal of headache and pain
2025

A case report: Infrazygomatic approach neurocryoablation of the sphenopalatine ganglion under cone beam computer tomography guidance in treating refractory headaches.

Interventional pain medicine
2025

A novel scoring system as a predictor for delayed pain disappearance after percutaneous balloon compression for trigeminal neuralgia.

European journal of medical research
2026

Biologically Effective Dose and Dose Rate in Gamma Knife Radiosurgery for Trigeminal Neuralgia: A Systematic Review and Meta-Analysis.

Advances in radiation oncology
2025

The Neural Mechanisms of rTMS and Placebo Effects in Trigeminal Neuralgia: Evidence From fMRI Network Dynamics.

Journal of pain research
2025

Efficacy analysis of percutaneous balloon compression therapy for trigeminal neuralgia guided by three-dimensional digital subtraction angiography navigation.

Frontiers in neurology
2025

Long-term outcomes of microvascular decompression for trigeminal neuralgia in multiple sclerosis: a systematic review and meta-analysis.

Journal of neurosurgery
2025

Ultra-early Gamma Knife stereotactic radiosurgery for trigeminal neuralgia (URGEnt-TN): study protocol for a single-center, two-arm, parallel group design, pragmatic, noninferiority, phase II, randomized controlled trial with intention-to-treat analysis for pre-refractory GK-SRS in classical or idiopathic TN.

Trials
2026

Giant trigeminal schwannoma with cavernous sinus and brainstem involvement: Multimodal imaging and multidisciplinary surgical management.

Radiology case reports
2025

Microvascular Decompression for Trigeminal Neuralgia Secondary to Vertebrobasilar Dolichoectasia: A Case Report and Review of the Literature.

Asian journal of neurosurgery
2025

Trigeminal nerve root compression induced neuroinflammatory response promotes mechanical allodynia through the CGRP/SP-Piezo2 axis via Ca2+ signaling.

Cellular &amp; molecular biology letters
2026

Percutaneous Balloon Compression Exerts Multidimensional Efficacy in Trigeminal Neuralgia via Neuroinflammation and Neurotransmitter Regulation.

World neurosurgery
2026

Stereotactic radiosurgery for trigeminal neuralgia secondary to Multiple Sclerosis: A systematic review and Meta-Analysis.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
2025

In Response to Comment on"The Efficacy and Safety of Applying the Combination of Pulsed Radiofrequency and Platelet-Rich Plasma to the Gasserian Ganglion for the Treatment of Idiopathic Trigeminal Neuralgia: A Protocol for A Multi-Center, Prospective, Open-Label, Propensity Score Match Cohort Study".

Pain physician
2025

Pulsed Radiofrequency Treatment: Evidence for and Applications in Chronic Pain.

Pain physician
2025

Indeterminate dental pain: clinical characteristics and neurovascular compression; a retrospective case comparative study.

Frontiers in pain research (Lausanne, Switzerland)
2025

Anatomical variability of the lateral pterygoid plate and its influence on the dimensions of infratemporal fossa in human skulls.

Scientific reports
2025

Venous sinus stenting for cerebral venous congestion-induced trigeminal neuralgia: A case report.

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences
2025

[Radiosurgery for neurosurgical diseases (by the 20th anniversary of neuroradiosurgery in Russia)].

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko
2025

Magnetic resonance imaging in the diagnosis of trigeminal neuralgia: a systematic review of the imaging protocol and diagnostic accuracy.

European radiology
2025

Reducing complications using minimally invasive retrosigmoid approach for microvascular decompression in patients with trigeminal neuralgia.

Neurosurgical review
2025

Use of Cannabidiol and Cannabigerol in the Treatment of Trigeminal Neuralgia and Postherpetic Pain.

Contemporary clinical dentistry
2025

Aggressive Disease and Poor Clinical Outcome in CEBPα-Mutated Acute Myeloid Leukemia Patient.

Clinical case reports
2025

Short- and Long-Term Pain Relief With Radiofrequency Rhizotomy in Multiple Sclerosis Patients With Trigeminal Neuralgia: A Systematic Review.

Cureus
2026

Advantages of trigeminal nucleotractotomy to treat cancer facial pain: a systematic review.

Pain management
2026

Percutaneous glycerol rhizotomies are effective in achieving immediate but not long-term pain reduction in patients with trigeminal neuralgia: A contemporary cohort analysis.

Clinical neurology and neurosurgery
2025

Predictors of Pain Relief after Index Gamma Knife Radiosurgery for Trigeminal Neuralgia: Retrospective Analysis of a 25-Year Series.

Stereotactic and functional neurosurgery
2025

Impact of Ultrasound-guided Superficial Cervical Plexus Block on Early Postoperative Recovery in Patients Undergoing Microvascular Decompression: A Randomized Controlled Trial.

Journal of neurosurgical anesthesiology
2025

Reduced volume in the amygdala of trigeminal neuralgia patients: a neuroimaging study with clinical correlates.

Experimental brain research
2025

Internal Neurolysis for Glossopharyngeal Neuralgia without Vascular Compression: Report of 2 Cases.

NMC case report journal
2025

Trigeminal root demyelination is sufficient to induce trigeminal neuralgia-like facial pain in adult rodents.

The journal of headache and pain
2025

An exploratory study of urinary proteome in trigeminal neuralgia.

Frontiers in molecular biosciences
2026

Toothaches of Non-odontogenic Origin.

Dental clinics of North America
2025

Surgical Concept and Long-Term Outcomes of Various Case-by-Case Decompressive Techniques for Trigeminal Neuralgia Caused by the Trigeminocerebellar Artery.

Operative neurosurgery (Hagerstown, Md.)
2025

Homogeneous groups are required to assess the effect of unilateral thalamotomy by Gamma Knife radiosurgery on refractory trigeminal neuralgia.

Surgical neurology international
2025

Posterior reversible encephalopathy syndrome after trigeminal microvascular decompression: A case report.

Surgical neurology international
2026

Jujuboside A Alleviates Facial Allodynia of CCI-ION Rats by Inhibiting the Expression of P2X7 Receptor in the Spinal Trigeminal Subnucleus Caudalis.

Journal of oral pathology &amp; medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
2025

Brain aging among individuals with trigeminal neuralgia.

Neurobiology of pain (Cambridge, Mass.)
2025

Cranial Neurolymphomatosis Presenting With Trigeminal Neuralgia and Facial and Vagus Nerve Palsies Visualized on Fluorodeoxyglucose Positron-Emission Tomography (FDG PET).

Cureus
2025

Acute brain swelling due to intraoperative supratentorial subdural hematoma during microvascular decompression: a case report.

Frontiers in surgery
2026

Facial onset sensory and motor neuronopathy: a diagnostic challenge.

Acta neurologica Belgica
2025

Refractory Trigeminal Neuralgia: The Role of MRI in Diagnosing Neurovascular Compression.

Revista de neurologia
2026

Intravenous magnesium and methocarbamol for acute pain crises in refractory trigeminal neuralgia: A retrospective analysis.

Headache
2025

Somatotopic sensory trigeminal rootlets identification via unmasked trigemino-facial reflexes. Insights from trigeminal nerve surgery.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
2025

Effectiveness of Electroacupuncture Combined with Pregabalin in the Treatment of Trigeminal Herpetic Neuralgia: A Multicenter Randomized Controlled Trial Study Protocol.

Complementary medicine research
2025

A prospective real-world analysis of intravenous eptinezumab in migraine management: the first UK experience.

The journal of headache and pain
2025

Microvascular decompression for neurovascular compression syndromes secondary to vertebrobasilar dolichoectasia: a single-center retrospective analysis.

Frontiers in surgery
2025

Comparing large language models and human doctors in symptom-driven online medical consultations: A case study on trigeminal neuralgia.

Digital health
2025

Acute intracranial EBV and CMV infections after chemoimmunotherapy for EBV-associated nasopharyngeal carcinoma: a case report and literature review.

Frontiers in oncology
Ver todos os 5.898 no EuropePMC

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Doenças relacionadas

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. A Tac1-Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia.
    Advanced science (Weinheim, Baden-Wurttemberg, Germany)· 2026· PMID 41824792mais citado
  2. Retrospective evaluation of treatment outcomes of Gasserian ganglion radiofrequency thermocoagulation in trigeminal neuralgia patients with multiple sclerosis.
    Turkish journal of medical sciences· 2026· PMID 41816724mais citado
  3. Internal neurolysis for atypical facial pain: Clinical outcomes and validation of an intraoperative trigeminal pathology scoring system.
    Surgical neurology international· 2026· PMID 41783228mais citado
  4. Neuropsychiatric Disorders and Constipation: Unraveling Causal Links Through Genetic Analysis.
    Brain and behavior· 2026· PMID 41782465mais citado
  5. A case of myelin oligodendrocyte glycoprotein antibody-associated disease presenting with radiculopathies.
    Rinsho shinkeigaku = Clinical neurology· 2026· PMID 41692475mais citado
  6. Monitoring Nitric Oxide in Trigeminal Neuralgia Rats with a Cerium Single-Atom Nanozyme Electrochemical Biosensor.
    ACS Sens· 2026· PMID 41989020recente
  7. Response to letter to the editor regarding "electrophysiological monitoring of the trigeminal nerve sensory root using sensory-masseter response for microvascular decompression in trigeminal neuralgia".
    Acta Neurochir (Wien)· 2026· PMID 41984287recente
  8. Letter to the editor regarding "Electrophysiological monitoring of the trigeminal nerve sensory root using sensory-masseter response for microvascular decompression in trigeminal neuralgia".
    Acta Neurochir (Wien)· 2026· PMID 41984253recente
  9. Chrono-anatomical precision in salvage therapy for recurrent trigeminal neuralgia: mechanistic insights and cost-utility analysis of percutaneous balloon compression.
    Front Neurol· 2026· PMID 41982426recente
  10. Demonstrating Petrous Dural Incision Technique for Vascular Releasing and Transposition of Dura-Embedded Subarcuate Loop of Anterior Inferior Cerebellar Artery During Retrosigmoid Approach.
    Neurosurg Pract· 2026· PMID 41982322recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:221091(Orphanet)
  2. OMIM OMIM:190400(OMIM)
  3. MONDO:0008599(MONDO)
  4. GARD:7805(GARD (NIH))
  5. Busca completa no PubMed(PubMed)
  6. Artigo Wikipedia(Wikipedia)
  7. Q1132120(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Neuralgia do trigêmeo
Compêndio · Raras BR

Neuralgia do trigêmeo

ORPHA:221091 · MONDO:0008599
Prevalência
Unknown
Herança
Not applicable
CID-10
G50.0 · Nevralgia do trigêmeo
CID-11
Ensaios
38 ativos
Início
Adolescent, Adult, Elderly
Prevalência
0.0 (Worldwide)
MedGen
UMLS
C0040997
EuropePMC
Wikidata
Wikipedia
Papers 10a
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