Pular para o conteúdo
Polineuropatia desmielinizante inflamatória crônica
ORPHA:2932CID-10 · G61.8CID-11 · 8C01.3DOENÇA RARA
Esta doença tem causa genética. Recomendamos procurar um médico geneticista para diagnóstico, exames genéticos e aconselhamento familiar.
neuroInício infantilHerança Unknown
Também conhecida comoCIDP

Distúrbio neurológico raro em que há inflamação das raízes nervosas e nervos periféricos e destruição da cobertura protetora gordurosa (bainha de mielina) sobre os nervos. Isso afeta a rapidez com que os sinais nervosos são transmitidos e leva à perda de fibras nervosas. Isto causa fraqueza, paralisia e/ou comprometimento da função motora, especialmente dos braços e pernas (membros). Distúrbios sensoriais também podem estar presentes. As deficiências motoras e sensoriais geralmente afetam ambos os lados do corpo (simétricas), e o grau de gravidade e o curso da doença podem variar de caso para caso. Alguns indivíduos afetados podem seguir um padrão lento e constante de sintomas, enquanto outros podem apresentar sintomas que se estabilizam e depois recaem.

Última verificação: Fonte: sem afirmação sobre o SUS a verificarEm construçãohistóricoSugerir correção
Mantido por Agente Raras·Colaborar como especialista →

Introdução

O que você precisa saber de cara

💬
EM LINGUAGEM SIMPLES

A polineuropatia desmielinizante inflamatória crônica (CIDP) é uma doença neurológica rara que causa inflamação nos nervos e danifica a bainha de mielina, camada que os protege. Com o tempo, essa alteração prejudica o envio dos sinais nervosos e costuma provocar fraqueza simétrica nos braços e pernas, dormências e dificuldade para caminhar. A doença não consta na lista oficial de PCDTs de doenças raras do Ministério da Saúde e não possui medicamentos com fornecimento regularizado pelo SUS nesta listagem. No sistema público de saúde, os pacientes contam com o procedimento de atendimento em reabilitação voltado a doenças raras para suporte da mobilidade.

📋
Informacoes curadas por IA — podem conter imprecisoes

Distúrbio neurológico raro em que há inflamação das raízes nervosas e nervos periféricos e destruição da cobertura protetora gordurosa (bainha de mielina) sobre os nervos. Isso afeta a rapidez com que os sinais nervosos são transmitidos e leva à perda de fibras nervosas. Isto causa fraqueza, paralisia e/ou comprometimento da função motora, especialmente dos braços e pernas (membros). Distúrbios sensoriais também podem estar presentes. As deficiências motoras e sensoriais geralmente afetam ambos os lados do corpo (simétricas), e o grau de gravidade e o curso da doença podem variar de caso para caso. Alguns indivíduos afetados podem seguir um padrão lento e constante de sintomas, enquanto outros podem apresentar sintomas que se estabilizam e depois recaem.

Pesquisas ativas
56 ensaios
136 total registrados no ClinicalTrials.gov
Publicações científicas
2.389 artigos
Último publicado: 2026 Mar 31
Medicamentos
1 com registro
VYVGART Hytrulo (EFGARTIGIMOD ALFA AND HYALURONIDASE (HUMAN RECOMBINANT))

Tem tratamento?

✓ 1 medicamento específico desta doença (registro ANVISA, FDA ou SUS/CEAF)
Ver detalhes, fases e interações →
VYVGART HYTRULO (EFGARTIGIMOD ALFA AND HYALURONIDASE (HUMAN RECOMBINANT))

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
1-9 / 100 000
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
3.7
Europe
Início
Adolescent
+ adult, childhood, elderly
🏥
SUS: Cobertura mínimaScore: 15%
2 procedimentos SIGTAPCID-10: G61.8
🇧🇷Dados SUS / DATASUS
EXAMES E PROCEDIMENTOS RELACIONADOS (2)
•
Sequenciamento completo do exoma (WES)
•
Atendimento em reabilitação — doenças raras
Você se identifica com essa condição?
O Raras está aqui pra te apoiar — com ou sem diagnóstico

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Entender a doença

Do básico ao detalhe, leia no seu ritmo

Preparando trilha educativa...

Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🧠
Neurológico
5 sintomas
💪
Músculos
2 sintomas
🦴
Ossos e articulações
1 sintomas

+ 13 sintomas em outras categorias

Características mais comuns

90%prev.
Ataxia sensorial
Muito frequente (99-80%)
90%prev.
Disfunção somatossensorial
Muito frequente (99-80%)
90%prev.
Desmielinização/remielinização periférica segmentar
Muito frequente (99-80%)
90%prev.
Neuropatia periférica
Muito frequente (99-80%)
90%prev.
Fraqueza fatigável dos músculos proximais dos membros
Muito frequente (99-80%)
90%prev.
Velocidade de condução nervosa diminuída
Muito frequente (99-80%)
21sintomas
Muito frequente (12)
Frequente (8)
Ocasional (1)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 21 características clínicas mais associadas, ordenadas por frequência.

Ataxia sensorialSensory ataxia
Muito frequente (99-80%)90%
Disfunção somatossensorialSomatic sensory dysfunction
Muito frequente (99-80%)90%
Desmielinização/remielinização periférica segmentarSegmental peripheral demyelination/remyelination
Muito frequente (99-80%)90%
Neuropatia periféricaPeripheral neuropathy
Muito frequente (99-80%)90%
Fraqueza fatigável dos músculos proximais dos membrosFatiguable weakness of proximal limb muscles
Muito frequente (99-80%)90%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico2.389PubMed
Últimos 10 anos200publicações
Pico2025146 papers
Linha do tempo
2026Hoje · 2026🧪 1990Primeiro ensaio clínico📈 2025Ano de pico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
✓Aprovado4
3Fase 325
2Fase 216
1Fase 110
·Pré-clínico45
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 100 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Polineuropatia desmielinizante inflamatória crônica

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

Onde estão os ensaios

Com ensaio aberto em 51 países. O ponto verde marca onde há vaga agora.

🟢 Recrutando agora

39 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

NCT07091630 · A Study to Assess the Efficacy and Safety of Empasiprubart i…Recrutando
PHASE3🇧🇷 Brasil · 🇦🇷 Argentina · 🇦🇹 Áustria +21
NCT06920004 · A Study to Assess Efficacy and Safety of Empasiprubart Versu…Recrutando
PHASE3🇧🇷 Brasil · 🇦🇷 Argentina · 🇦🇺 Austrália +28
NCT07032662 · Imeroprubart in Adult Participants With Chronic Inflammatory…Recrutando
PHASE2🇧🇷 Brasil · 🇦🇷 Argentina · 🇦🇺 Austrália +27
NCT06858579 · A Study to Evaluate the Efficacy and Safety of DNTH103 in Ad…Recrutando
PHASE3🇧🇷 Brasil · 🇦🇷 Argentina · 🇦🇺 Austrália +27
NCT06290141 · A Study to Test the Efficacy and Safety of Riliprubart Again…Recrutando
PHASE3🇧🇷 Brasil · 🇦🇷 Argentina · 🇧🇪 Bélgica +21
NCT06752356 · A Study Investigating Intravenous Human Normal Immune Globul…Recrutando
PHASE3🇺🇸 Estados Unidos
NCT07304154 · A Study Evaluating the Safety and Efficacy of KITE-363 in Re…Recrutando
PHASE1🇦🇺 Austrália · 🇨🇦 Canadá · 🇺🇸 Estados Unidos
NCT07540221 · A Study to Evaluate the Pharmacokinetics and Safety of XEMBI…Recrutando
PHASE3🇨🇿 Tchéquia · 🇵🇱 Polônia · Romania +1
NCT07526493 · Safety and Pharmacodynamics of QH103 Cell Injection in the T…Recrutando
PHASE1🇨🇳 China
NCT07478172 · Effects of Whole-body Electrical Muscle Stimulation Exercise…Recrutando
NA🇺🇸 Estados Unidos
NCT07273903 · Subcutaneous Immunoglobulin Therapy Effectiveness Monitoring…Recrutando
🇩🇪 Alemanha
NCT07337785 · CD19/BCMA-Targeted UCAR-T for Patients With Neurological Aut…Recrutando
EARLY_PHASE1🇨🇳 China
NCT07154524 · Immunoadsorption for Treatment of Chronic Inflammatory Demye…Recrutando
🇩🇪 Alemanha
NCT07264426 · Real-World Efgartigimod Effectiveness in CIDP: A Prospective…Recrutando
🇩🇪 Alemanha · 🇺🇸 Estados Unidos
NCT06939166 · Universal Chimeric Antigen Receptor T-Cell (UCAR T-cell) The…Recrutando
EARLY_PHASE1🇨🇳 China
NCT06798012 · A Study of TAK-411 in Adults With Chronic Inflammatory Demye…Recrutando
PHASE2🇨🇦 Canadá · 🇨🇴 Colômbia · 🇺🇸 Estados Unidos
NCT06747351 · A Study to Compare TAK-881 and HYQVIA in Adults With Chronic…Recrutando
PHASE3🇦🇷 Argentina · 🇨🇿 Tchéquia · 🇩🇰 Dinamarca +8
NCT06680037 · A Study to Assess the Safety and Clinical Activity of Azer-c…Recrutando
PHASE1🇺🇸 Estados Unidos
NCT06538064 · A Study of HyQvia in Adults With Chronic Inflammatory Demyel…Recrutando
🇩🇰 Dinamarca · 🇩🇪 Alemanha · 🇺🇸 Estados Unidos
NCT06968975 · Real-world Study of Treatment Outcomes in Chronic Inflammato…Recrutando
🇺🇸 Estados Unidos
NCT07022197 · Safety and Efficacy of BAFF-R CART for Refractory Neuroimmun…Recrutando
PHASE1, PHASE2🇨🇳 China
NCT07461896 · Studying Nerve Function and Structure in Charcot-Marie-Tooth…Recrutando
🇮🇹 Itália
NCT06714838 · Rituximab Induced Remission in Patients With Chronic Inflamm…Recrutando
PHASE3🇳🇱 Países Baixos
NCT06615622 · Our Study Aims to Determine if Nerve Alterations in Acute GB…Recrutando
🇪🇬 Egito
NCT06502015 · Biomarkers in Autoimmune Disease of Nervous SystemRecrutando
🇨🇳 China
NCT06299748 · A Worldwide Pregnancy Safety Study to Assess Maternal, Fetal…Recrutando
🇩🇪 Alemanha · 🇮🇹 Itália · 🇪🇸 Espanha +1
NCT04929236 · Study to Evaluate Safety and Efficacy of Different PANZYGA D…Recrutando
PHASE3🇺🇸 Estados Unidos
NCT06183645 · Exploratory Study on Predicting CIDP Patients' Decline Durin…Recrutando
🇧🇪 Bélgica
NCT04881682 · Immunoadsorption Versus Immunoglobulins for Treatment of Chr…Recrutando
PHASE2🇩🇪 Alemanha
NCT05327114 · Efficacy and Safety Study of Nipocalimab for Adults With Chr…Recrutando
PHASE2, PHASE3🇦🇷 Argentina · 🇦🇺 Austrália · 🇨🇦 Canadá +16
NCT05584631 · IVIG vs SCIG in CIDPRecrutando
PHASE1🇺🇸 Estados Unidos
NCT04672733 · Hizentra® in Inflammatory Neuropathies - pHeNIx StudyRecrutando
🇫🇷 França
NCT05004493 · Biorepository and Registry for Plasma Exchange PatientsRecrutando
🇺🇸 Estados Unidos
NCT04561557 · Safety and Efficacy of CT103A Cells for Relapsed/Refractory …Recrutando
EARLY_PHASE1🇨🇳 China
NCT04589299 · Subcutaneous Immunoglobulin in De-novo CIDP (SIDEC)Recrutando
PHASE4🇩🇰 Dinamarca
NCT03684018 · Two Dose Levels of Privigen in Pediatric CIDPRecrutando
PHASE4🇺🇸 Estados Unidos
NCT06859099 · Long-term Safety and Efficacy Study of Riliprubart in Partic…Por convite
PHASE3🇧🇷 Brasil · 🇦🇷 Argentina · Bulgaria +21
NCT07072676 · The Use of Assistive Gait Devices Can Reduce the Risk of Fal…Por convite
NA🇩🇪 Alemanha
NCT06605612 · Development and Validation of the FBIndex to Determine the R…Por convite
🇩🇪 Alemanha

Outros ensaios clínicos

136 ensaios clínicos encontrados, 56 ativos.

Distribuição por fase
NCT07851844 · Clinical, Electrophysiological and Genetic Characteristics o…Em breve
🇫🇷 França
NCT07719153 · Ultrasound-driven Stratification in CIDPEm breve
NCT07638566 · A Study to Assess the Correct Dose, Safety and Efficacy of E…Em breve
PHASE2, PHASE3
NCT07696377 · An Exploratory Study of Obinutuzumab β in the Treatment of C…Em breve
PHASE1, PHASE2
NCT07333196 · Tongji NADs CohortEm breve
🇨🇳 China
NCT07121985 · Multispectral Optoacoustic Imaging for the Detection of Infl…Em breve
NCT07006597 · Vitaccess Real CIDP RegistryEm breve
NCT06858722 · Ripertamab for the Treatment of Chronic Inflammatory Demyeli…Em breve
PHASE3
NCT06485232 · Universal CAR-T Cells in Patients with Refractory Autoimmune…Em breve
EARLY_PHASE1🇨🇳 China
NCT05219383 · Clinical and Electrophysiological Patterns of Chronic Dysimm…Em breve
NCT06290128 · A Study to Test the Effects and Safety of Riliprubart in Peo…Ativo
PHASE3🇧🇷 Brasil · 🇦🇷 Argentina · 🇧🇪 Bélgica +21
NCT07597733 · Telitacicept for Refractory Chronic Inflammatory Demyelinati…Ativo
NA🇨🇳 China
NCT06620198 · Upper Limb Robot-Assisted Therapy in Patients With Guillain-…Ativo
PHASE4🇮🇹 Itália
NCT06040567 · Polyneuropathy, Impairments and Physical Activity - The Poly…Ativo
🇩🇰 Dinamarca
NCT04280718 · A Study to Assess the Long-term Safety and Efficacy of a Sub…Ativo
PHASE2🇦🇹 Áustria · 🇧🇪 Bélgica · Bulgaria +21
NCT03584022 · Clinical Trial to Assess the Safety of a Novel Scaffold Biom…Ativo
NA🇺🇸 Estados Unidos
NCT00716066 · Autologous Stem Cell Transplant for Neurologic Autoimmune Di…Ativo
PHASE2🇺🇸 Estados Unidos
NCT02955355 · Long-Term Tolerability and Safety of HYQVIA/HyQvia in CIDPConcluído
PHASE3🇧🇷 Brasil · 🇦🇷 Argentina · 🇨🇦 Canadá +15
NCT02549170 · A Study of HyQvia and Gammagard Liquid (Kiovig) in Adults Wi…Concluído
PHASE3🇧🇷 Brasil · 🇦🇷 Argentina · 🇨🇦 Canadá +19
NCT06637072 · A Study to Assess Adults With CIDP Transitioning From IVIg t…Concluído
PHASE4🇺🇸 Estados Unidos
NCT07343310 · A First-in-Patient Clinical Trial of KINE-101 in Patients Wi…Concluído
PHASE1South Korea
NCT05723848 · Electronic Monitoring of Disease Activity in Patients With C…Concluído
🇩🇪 Alemanha
NCT05363358 · A Safety Study of GAMMAGARD LIQUID (GGL) in Participants Wit…Concluído
🇺🇸 Estados Unidos
NCT05084053 · A Study of TAK-771 in Japanese Participants With Chronic Inf…Concluído
PHASE3🇯🇵 Japão
NCT04978623 · Role of High Frequency Ultrasound in Demyelinating Polyneuro…Concluído
🇫🇷 França
NCT04154540 · Posturography-NeuropathyConcluído
NA🇫🇷 França
NCT04658472 · Proof-of-concept Study for SAR445088 in Chronic Inflammatory…Concluído
PHASE2🇨🇦 Canadá · 🇨🇳 China · 🇫🇷 França +7
NCT04818177 · Immunoglobulin G Therapy Dose OptimizationConcluído
🇺🇸 Estados Unidos
NCT04742374 · Effects of Single Plasma Exchange and Double Filtration Plas…Concluído
EARLY_PHASE1🇫🇷 França
NCT04356781 · Do IgG Level Variations in CIDP and MMN Patients Following I…Concluído
🇬🇧 Reino Unido
NCT04281472 · A Study to Assess the Safety and Efficacy of a Subcutaneous …Concluído
PHASE2🇦🇹 Áustria · 🇧🇪 Bélgica · Bulgaria +22
NCT04051944 · A Study to Assess Long-term Safety, Tolerability and Efficac…Concluído
PHASE2🇧🇪 Bélgica · 🇩🇰 Dinamarca · 🇫🇷 França +5
NCT03967899 · Study of Electrical Prognostic Factors of Response to Intrav…Concluído
🇫🇷 França
NCT06325943 · Rituximab in Chronic Inflammatory Demyelinating Polyradiculo…Concluído
PHASE3🇮🇹 Itália
NCT03864185 · The Evaluation of Efficacy and Safety of Rituximab in Refrac…Concluído
PHASE2🇯🇵 Japão
NCT03861481 · A Study to Assess the Efficacy, Safety and Tolerability of R…Concluído
PHASE2🇧🇪 Bélgica · 🇩🇰 Dinamarca · 🇫🇷 França +5
NCT03008733 · Descriptive Analysis of Morphological Aspects of Nerve by Ul…Concluído
NA🇫🇷 França
NCT03397303 · Quantification of Nerve Stiffness in NeuropathiesConcluído
NA🇫🇷 França
NCT02967679 · SERENDEM : MD1003 in Patients Suffering From Demyelinating N…Concluído
PHASE2🇫🇷 França
NCT02892890 · Exploratory Study of Predictive Markers of the Therapeutic R…Concluído
NA🇫🇷 França
NCT04687332 · IA or PE - What is the Best Treatment Option of Steroid Refr…Concluído
NA🇩🇪 Alemanha
NCT02293460 · Efficacy and Safety Study of I10E in Treatment of Patients W…Concluído
PHASE3🇫🇷 França · 🇮🇹 Itália · 🇪🇸 Espanha +3
NCT02414490 · IVIg Treatment-Related Fluctuations in CIDP Patients Using D…Concluído
🇺🇸 Estados Unidos
NCT02465359 · Subcutaneous Immunoglobulin for Chronic Inflammatory Demyeli…Concluído
NA🇺🇸 Estados Unidos
NCT02027701 · Extension Study of Maintenance Treatment With Subcutaneous I…Concluído
PHASE3🇦🇺 Austrália · 🇨🇦 Canadá · 🇨🇿 Tchéquia +8
NCT02017769 · MRI in Diagnosing and Monitoring CIDPConcluído
🇩🇰 Dinamarca
NCT02629796 · Biomark Study: Predict Intravenous Immunoglobulin Responders…Concluído
🇫🇷 França
NCT02121678 · Effect of Resistance and Aerobic Exercise in CIDP or MMNConcluído
NA🇩🇰 Dinamarca
NCT02111590 · Immunoglobulin Dosage and Administration Form in CIDP and MM…Concluído
🇩🇰 Dinamarca
NCT03460951 · Diffusion Tensor Imaging in Chronic Inflammatory Demyelinati…Concluído
🇫🇷 França
NCT01847937 · Magnetic Resonance Diagnostics of Diabetic Peripheral Neurop…Concluído
🇩🇰 Dinamarca · 🇩🇪 Alemanha
NCT01824251 · Phase III Clinical Trial of NPB-01maintenance Therapy in Pat…Concluído
PHASE3🇯🇵 Japão
NCT01625182 · Evaluate Efficacy and Safety of Fingolimod 0.5 mg Orally Onc…Concluído
PHASE3🇦🇺 Austrália · 🇧🇪 Bélgica · 🇨🇦 Canadá +12
NCT01545076 · Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) and…Concluído
PHASE3🇦🇺 Austrália · 🇧🇪 Bélgica · 🇨🇦 Canadá +13
NCT01379833 · Prevalence of Decreased Corneal Sensation in Patients With C…Concluído
🇺🇸 Estados Unidos
NCT01184846 · Study of Efficacy and Safety of Privigen in Subjects With Ch…Concluído
PHASE3🇧🇪 Bélgica · 🇫🇮 Finlândia · 🇫🇷 França +2
NCT01017159 · Subcutaneous Immunoglobulin Treatment of Patients With Chron…Concluído
PHASE2🇩🇰 Dinamarca
NCT00962429 · Lipoic Acid to Treat Chronic Inflammatory Demyelinating Poly…Concluído
PHASE2🇺🇸 Estados Unidos
NCT00305266 · Study of CIDP Patients During IVIG TreatmentConcluído
🇩🇰 Dinamarca
NCT00278629 · Hematopoietic Stem Cell Transplantation in Chronic Inflammat…Concluído
PHASE2🇺🇸 Estados Unidos
NCT01349270 · Randomized Open-label Trial to Compare Efficacy and Toleranc…Concluído
PHASE3🇫🇷 França
Ver todos no ClinicalTrials.gov
🧪 Está conduzindo uma pesquisa?
Divulgue para pacientes e familiares que acompanham esta doença.
Divulgar pesquisa →

Publicações mais relevantes

🥈Melhor nível de evidência: Ensaio clínico
Timeline de publicações
1.256 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 1.256

#1

Clinical features of chronic inflammatory demyelinating polyneuropathy: a single-center experience with 33 patients.

Frontiers in neurology2026

Chronic inflammatory demyelinating polyneuropathy (CIDP) is an immune-mediated neuropathy with heterogeneous clinical presentations. Although several clinical subtypes, including typical and variants, have been described, evidence regarding their distribution and treatment outcomes remains limited, particularly for CIDP variants. We retrospectively analyzed 33 consecutive patients diagnosed with CIDP at Kumamoto University Hospital between January 2020 and March 2025. Clinical data included demographic characteristics, disease duration, subtype classification, electrophysiological and cerebrospinal fluid (CSF) findings, imaging findings, treatment details, and treatment responsiveness. Subtypes were classified according to the 2021 EAN/PNS diagnostic criteria. Treatment responsiveness was defined as objective improvement confirmed by at least two neurologists. Among the 33 patients, 36.4% had typical CIDP and 63.6% had CIDP variants, including distal (39.4%), multifocal (15.2%), motor (3.0%), and sensory (6.0%) subtypes. Distal CIDP was the most frequent subtype. Patients with multifocal CIDP experienced the longest diagnostic delays (mean, 4.6 years) due to fewer demyelinating findings on electrophysiological studies. The MRC sum score was lowest in typical CIDP, suggesting greater disease severity. Intravenous immunoglobulin (IVIg) demonstrated high efficacy across all subtypes, including multifocal CIDP, in contrast to previous reports of lower responsiveness. During a mean follow-up period of 5.1 years, 78.8% of patients required maintenance therapy, most commonly IVIg and corticosteroids. No changes in clinical subtypes were observed during follow-up. In this single-center study, variants outnumbered typical CIDP, reflecting the case mix at a specialized tertiary referral center. Multifocal CIDP showed the longest diagnostic delays. IVIg demonstrated high efficacy across subtypes, including multifocal CIDP, contrasting with previous reports. These findings highlight the importance of improving diagnostic accuracy and establishing individualized long-term treatment strategies for CIDP.

#2

Clinical and laboratory features of juvenile-onset anti-NF155 autoimmune nodopathy.

Journal of neurology, neurosurgery, and psychiatry2026 Mar 03

Neurofascin 155 autoimmune nodopathy (NF155 AN) is a recently recognised immune-mediated neuropathy distinct from chronic inflammatory demyelinating polyneuropathy. While adult-onset cases have been increasingly reported, the juvenile-onset form remains poorly characterised. We retrospectively analysed 36 patients with NF155 AN, focusing on detailed characterisation of 16 juvenile-onset cases. Their clinical and laboratory data were reviewed. Juvenile-onset patients presented with sensorimotor neuropathy characterised by distal predominant weakness, tremor and sensory ataxia. Motor symptoms were the presenting feature in 75% of patients, which significantly differed from the adult cases (p=0.0015). Postural tremor was more frequent in juvenile patients (94%), while cranial nerve involvement was less common (19%). Electrophysiologically, absent compound muscle action potentials in lower limbs were significantly more prevalent in juvenile patients (peroneal: 78%; tibial: 66%; p<0.001 for both). Symmetrical spinal root/plexus hypertrophy on MR neurography and characteristic pathological findings were observed in both groups. Intravenous immunoglobulin response was generally poor, while delayed rituximab initiation still led to clinical improvement in the juvenile-onset group. Juvenile patients showed trends towards better functional outcomes. Juvenile-onset NF155 AN is distinguished by motor-predominant onset, frequent tremor and characteristic electrophysiological abnormalities, yet demonstrates favourable prognosis with B-cell targeted therapy. Early recognition and timely diagnosis are essential for optimal outcomes.

#3

Non-sensorimotor symptoms in chronic inflammatory demyelinating polyneuropathy.

Journal of neurology2026 Mar 03

Chronic inflammatory demyelinating polyneuropathy (CIDP) is defined as a dysimmune disorder of the peripheral nervous system (PNS) resulting in sensorimotor deficits. However, an increasing body of data suggests that CIDP also goes along with features, such as autonomic, circadian, fatigue, mood, and subtle cognitive dysfunctions. Some of these non-sensorimotor symptoms (NSMS) challenge the concept of an exclusive PNS disease. Pragmatically, the high prevalence of NSMS calls for a more holistic disease assessment and surveillance to achieve optimal therapeutic results.

#4

The actual usefulness of culturing apheresis products in hematopoietic stem cell autotransplants.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis2026 Apr

Bacterial cultures of apheresis products are mandated by FACT-JACIE standards as a safety measure in autologous hematopoietic stem cell transplantation (aHSCT). However, results are often available only after reinfusion, raising questions about their clinical utility, particularly in programs that use fresh, non-cryopreserved products. To evaluate the incidence, microbiological profile, and clinical relevance of positive bacterial cultures in apheresis products used for aHSCT in autoimmune diseases. This prospective study included 629 apheresis products administered to 586 patients with MS or CIDP who underwent outpatient, non-cryopreserved aHSCT between July 2021 and March 2025. Bacterial cultures were performed from product aliquots using the BACTEC system (aerobic and anaerobic bottles). Positive isolates underwent antibiotic susceptibility testing. Culture results, timing of positivity, and 28-day post-infusion outcomes were analyzed. Bacterial contamination was detected in 8 of 629 products (1.3 %). In one case, Escherichia coli was isolated within 24 h, leading to identification of a urinary tract infection and fatal sepsis in the patient; the contaminated product was discarded. The remaining seven cases became positive after 2-11 days (median: 6), when products had already been infused. Isolates included Cutibacterium acnes (n = 6), Staphylococcus capitis (n = 1), and Coryneform bacteria (n = 1). All were considered contamination during aliquot handling. No clinical complications occurred in these patients during the 28-day follow-up. Routine bacterial cultures of apheresis products yielded clinically relevant information in only 1 of 629 procedures. Most positive results reflected contamination of aliquots rather than true product infection, suggesting that the value of routine cultures in fresh aHSCT for autoimmune diseases may be limited and warrants re-evaluation.

#5

Benefits and challenges in everyday life for patients performing subcutaneous immunoglobulin treatment at home: a qualitative interview study.

BMJ open2026 Jan 30

Across medicine, new therapies are shifting treatment from clinic to home settings. At-home subcutaneous immunoglobulin treatment for immunodeficiency is an example of one such therapy. In this qualitative interview study, we investigated experiences of patients living an everyday life with subcutaneous immunoglobulin at-home treatment. 24 Danish patients participated in semistructured interviews. Six patients were interviewed in individual home-visit interviews, while the remaining 18 participated in one of six subsequent group interviews using an online video format. Participants represented three patient groups: patients with primary immunodeficiency, patients with secondary immunodeficiency, and patients with chronic inflammatory demyelinating polyneuropathy or multifocal motor neuropathy. According to the interviewed patients, at-home treatment provided a high degree of flexibility and freedom in everyday life. When transitioning to at-home treatment, a sense of security had been achieved through individualised training and access to healthcare professionals. Some patients experienced uncertainty or insecurity during the initial period of administering treatment at home; however, this typically receded over time. For the patients, at-home treatment had become embedded in everyday life either through incorporation into existing everyday routines or through the development of new routines. The time-related and place-related flexibility of the at-home treatment had benefits for several arenas of everyday life: work, family, and leisure. Patients associated at-home treatment with a sense of freedom, which they ascribed both to independence from the hospital and to not being confronted with medical conditions and other patients in the hospital setting. A small minority of the patients viewed the reduced contact with healthcare professionals as a disadvantage, describing feelings of being alone and responsible for their treatment. Patients who had established at-home treatment routines in their everyday lives found the benefits of at-home treatment to outweigh the challenges.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC1.138 artigos no totalmostrando 196

2026

When Foot Drop Tells a Bigger Story: POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Plasma Cell Disorder, and Skin Changes) Syndrome Revealed by Femoral Plasmacytoma.

Cureus
2026

Clinical Features and Management of Optic Neuritis in a Cohort of Patients with Combined Central and Peripheral Demyelination.

Neuro-ophthalmology (Aeolus Press)
2026

Clinical features of chronic inflammatory demyelinating polyneuropathy: a single-center experience with 33 patients.

Frontiers in neurology
2026

Distinct cerebrospinal fluid profiles of astrocytic aquaporin-4 and GFAP in neuroinflammatory disorders.

Neurobiology of disease
2026

CIDP With and Without Monoclonal Gammopathy of Undetermined Significance (MGUS): Comparison of Clinical Phenotype, Diagnostic Features, and Treatment Response.

Journal of the peripheral nervous system : JPNS
2026

Biallelic Variants in RNU6ATAC Result in a Minor Spliceopathy Characterized by Transcriptome-Wide Minor Intron Retention Events and Short Stature with Variable Multisystem Manifestations.

HGG advances
2026

Clinical and laboratory features of juvenile-onset anti-NF155 autoimmune nodopathy.

Journal of neurology, neurosurgery, and psychiatry
2026

Non-sensorimotor symptoms in chronic inflammatory demyelinating polyneuropathy.

Journal of neurology
2026

Rethinking rituximab in neuroimmunology: Real-world efficacy, cost-effectiveness, and long-term remission.

Journal of neuroimmunology
2026

Familial Occurrence of Anti-NF155 Autoimmune Nodopathy in Father and Son: Expanding the Spectrum of IgG4-Related Nodopathies.

Case reports in neurological medicine
2026

A case report of arsenic-induced peripheral neuropathy misdiagnosed as Guillain-Barré syndrome.

Frontiers in toxicology
2026

Plasma neurofilament light chain is associated with clinical instability in chronic autoimmune neuropathies.

Scientific reports
2026

Genetic risk of chronic pain conditions associated with risk of suicide death through an integrative analysis of EHR and genomics data.

Translational psychiatry
2025

Real-world treatment utilization in adults with chronic inflammatory demyelinating polyneuropathy in the United States.

Frontiers in neurology
2026

CAR-T manufacturing reduces heterogeneity between CIDP and multiple myeloma patient-derived T cells.

Theranostics
2026

Case-Based Lessons on Remote Patient Monitoring in Neurology Using Consumer-Grade Wearables.

Journal of central nervous system disease
2026

POEMS syndrome with cardiovascular lesions as the initial manifestation: a case report and literature review.

Frontiers in cardiovascular medicine
2026

The actual usefulness of culturing apheresis products in hematopoietic stem cell autotransplants.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis
2026

Subacute cutaneous lupus erythematosus secondary to intravenous immunoglobulin therapy for chronic inflammatory demyelinating polyneuropathy: A case report.

JAAD case reports
2026

Elucidating Causal Associations Between Immune Cells, Circulating Inflammatory Proteins, and Chronic Inflammatory Demyelinating Polyneuropathy: A Two-Sample Two-Step Mendelian Randomization Study.

Journal of the peripheral nervous system : JPNS
2026

Chronic Inflammatory Demyelinating Polyneuropathy Following Adalimumab Therapy for a Patient with Intestinal Behçet's Disease.

Digestive diseases and sciences
2026

Successful Treatment of Multifocal Demyelinating Sensory-Motor Neuropathy (Lewis-Sumner Syndrome) With Rituximab: A Case Report.

The American journal of case reports
2026

Benefits and challenges in everyday life for patients performing subcutaneous immunoglobulin treatment at home: a qualitative interview study.

BMJ open
2026

Combined Central and Peripheral Demyelination with a Favorable Outcome: A Case with 10-Year Follow-up.

Noro psikiyatri arsivi
2026

Corneal confocal microscopy as a paraclinical test in neurodegenerative disease: a scoping review.

The British journal of ophthalmology
2025

Genetic and metabolic inflammation signatures in chronic inflammatory demyelinating polyneuropathy: the role of IL18 polymorphisms and short-chain fatty acids.

Frontiers in molecular neuroscience
2025

Case report: Efgartigimod treatment in two pediatric patients with chronic inflammatory demyelinating polyneuropathy.

Frontiers in immunology
2026

Blood-Nerve Barrier Breakdown Induced by Immunoglobulin G in Typical and Multifocal Chronic Inflammatory Demyelinating Polyneuropathy and Multifocal Motor Neuropathy.

International journal of molecular sciences
2026

Practical Approach to Managing SCIg Treatment in Patients With Chronic Inflammatory Demyelinating Polyneuropathy.

Muscle &amp; nerve
2026

Conduction Block Detection in Dysimmune Neuropathy: Hypothetical Pathophysiological 'Truth' Versus Clinical Pragmatism.

European journal of neurology
2025

Characteristics of adverse events and clinical risks of intravenous immunoglobulin: a pharmacovigilance study based on FDA Adverse Event Reporting System (FAERS).

Frontiers in medicine
2026

Evaluating the short-term and long-term therapeutic effects of immunoadsorption compared with plasma exchange in chronic inflammatory demyelinating polyneuropathy: a long-term, prospective, observational study.

EClinicalMedicine
2026

Neurological Complications Associated With COVID-19 Compared to Other Viral Infections: A Systematic Review of Current Evidence.

Cureus
2026

Cost Analysis of Immunoglobulin Maintenance Treatment of Patients with Chronic Inflammatory Demyelinating Polyneuropathy in Spain.

PharmacoEconomics - open
2026

Immunotherapies on Guillain-Barré syndrome and other acute autoimmune neuropathies.

Handbook of clinical neurology
2026

FcRn inhibitors: A new era in neurotherapeutics.

Handbook of clinical neurology
2026

Incidence, Prevalence, and Treatment Patterns in Chronic Inflammatory Demyelinating Polyneuropathy: Data Analysis of US Claims.

Neuroepidemiology
2026

Significance of aberrant nerve conduction in hereditary transthyretin amyloidosis.

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis
2025

Biopsy of the Superficial Sensory Radial Nerve in the Distal Forearm: A Technical Note.

Cureus
2026

DISTRICTS trial: enhancing carpal tunnel syndrome treatment - Authors' reply.

Lancet (London, England)
2026

Efficacy, Safety, and Tolerability of Subcutaneous Efgartigimod PH20 in Chinese Patients With Chronic Inflammatory Demyelinating Polyneuropathy: A Prespecified Subpopulation Analysis of the Multicentre, Randomised-Withdrawal, Double-Blind, Placebo-Controlled, Phase II ADHERE Trial.

Journal of clinical neurology (Seoul, Korea)
2026

Immunotherapy in Chronic Inflammatory Demyelinating Polyneuropathy and the Emerging Role of Efgartigimod.

Journal of clinical neurology (Seoul, Korea)
2026

Paraneoplastic neurological syndrome with Guillain-Barré syndrome overlap in small-cell lung carcinoma: A case report from a primary care hospital in China.

Medicine
2026

Aberrant Complement Activation Is a Prominent Feature of Chronic Inflammatory Demyelinating Polyneuropathy.

Neurology(R) neuroimmunology &amp; neuroinflammation
2026

Persistent COVID-19 Pneumonia in a Patient on Rituximab.

Journal of investigative medicine high impact case reports
2025

Shaping the role of plasma exchange in autoimmune neurology: lessons learned from 67 years and over 90,000 procedures.

Therapeutic advances in neurological disorders
2025

Efficacy of intravenous immunoglobulin in patients with chronic inflammatory demyelinating polyneuropathy with or without diabetes: insights from a multicenter prospective comparative study.

Therapeutic advances in neurological disorders
2025

Chronic Inflammatory Demyelinating Polyneuropathy Presenting With Isolated Distal Fingertip Paresthesia in a Factory Worker With Ulcerative Colitis: A Case Report.

Cureus
2026

Ocular and Neuro-Ophthalmic Manifestations of Chronic Inflammatory Demyelinating Polyneuropathy.

International ophthalmology clinics
2025

Highly Immunoresistant Acute Motor and Sensory Axonal Neuropathy With Concomitant Anti-NF155 Axonal Nodopathy: A Case Report.

Cureus
2025

Experiences of Immunoglobulin Therapy for Those with a Confirmed Diagnosis of Chronic Inflammatory Demyelinating Polyneuropathy: A Mixed-Methods Study with a Qualitative Patient Perspective Focus.

Patient preference and adherence
2025

Intermittent immunoadsorption in critically ill patients with neuroimmunological disorders: a retrospective study.

Frontiers in neurology
2025

Autoimmune Neuromuscular Disorders at a Molecular Crossroad: Linking Pathogenesis to Targeted Immunotherapy.

International journal of molecular sciences
2026

A combined approach of Interleukin-8 and magnetic resonance neurography to differentiate Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy.

Journal of the neurological sciences
2025

Case Report: Secondary myelodysplastic syndrome following autologous stem cell transplantation in a patient with POEMS syndrome.

Frontiers in immunology
2026

Characterizing Treatment Patterns and Healthcare Use in Patients and Subgroups with Chronic Inflammatory Demyelinating Polyradiculoneuropathy: A Real-World Study.

Neurology and therapy
2025

Autoimmune neuropathies: New guidelines and expert insights into clinical decision making.

Journal of the neurological sciences
2026

Clinical, serological, and electrophysiological differences in chronic inflammatory demyelinating polyradiculoneuropathy patients with and without malignancy - real-life evidence.

Neurologia i neurochirurgia polska
2025

Case Report: Staged bilateral pancarpal arthrodesis using 3D-printed patient specific guides and customized hybrid plate for severe carpal joint instability associated with chronic inflammatory demyelinating polyneuropathy in a miniature dachshund.

Frontiers in veterinary science
2025

Deep Learning-Assisted Differentiation of Four Peripheral Neuropathies Using Corneal Confocal Microscopy.

Annals of clinical and translational neurology
2026

Efficacy and safety of intravenous efgartigimod for chronic inflammatory demyelinating polyneuropathy: A case series real-world study.

Journal of neuroimmunology
2026

Clinical Utility of Serum Neurofilament Light Chain in Peripheral Neuropathy.

Muscle &amp; nerve
2025

Wearable Monitoring Captures Sleep Disturbances in Patients With Chronic Inflammatory Demyelinating Polyneuropathy.

Journal of the peripheral nervous system : JPNS
2025

[POEMS syndrome: A complex diagnostic case under the guise of chronic polyneuropathy].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
2025

Very High Dose Immunoglobulin Treatment for Chronic Inflammatory Demyelinating Polyneuropathy: A Multicentre UK Study.

European journal of neurology
2026

Switch from Intravenous to Subcutaneous Immunoglobulin in CIDP and MMN: 12 Months Results from an Observational Study.

Neurology and therapy
2026

An Evaluation of the Real-World Effectiveness of Immunoglobulin Therapy in Chronic Inflammatory Demyelinating Polyneuropathy.

Neurology and therapy
2025

Cognitive impairment in chronic inflammatory demyelinating polyneuropathy.

Journal of neurology
2025

Recurrent Guillain-Barré Syndrome: A Case Report and Literature Review.

Cureus
2025

Effectiveness and safety of therapeutic plasma exchange in neurological disorders; measuring the response to treatment using Modified Rankin Scale - A single-center study.

Asian journal of transfusion science
2025

AXIN1, STAMBP, ST1A1, CDCP1, and SIRT2 Validated as Myasthenia Gravis Biomarkers: A Comparative Proteomic Study With MS, CIDP, and Controls.

European journal of neurology
2025

Diffusion Tensor Imaging Reveals Altered Centrality of Pain-Related Regions in SCN9A-Associated Small Fiber Neuropathy.

Journal of neuroimaging : official journal of the American Society of Neuroimaging
2025

BurstDR spinal cord stimulation for chronic inflammatory demyelinating polyneuropathy.

Surgical neurology international
2025

Delayed treatment and diagnostic challenges in differentiating multifocal acquired demyelinating sensory and motor neuropathy from lupus: a case report and literature review.

AME case reports
2025

Abnormal Sleep in Chronic Inflammatory Demyelinating Polyneuropathy.

European journal of neurology
2026

Intravenous immunoglobulin weaning evaluation with zero-shot large language model classification.

Transfusion medicine (Oxford, England)
2025

The potential role of IgG subclass in NF155-associated nodopathy for targeting therapy: a pediatric case report highlighting the efficacy of pulsed oral corticosteroids.

BMC neurology
2025

Immune-Mediated Neuropathies Other Than Typical Chronic Inflammatory Demyelinating Polyradiculoneuropathy-Multifocal Motor Neuropathy, Autoimmune Nodopathies, Anti-Myelin Associated Glycoprotein Neuropathy, Chronic Inflammatory Sensory Polyradiculoneuropathy, and Chronic Ataxic Neuropathy with Ophthalmoplegia, M-Protein, Agglutinin, and Disialosyl Antibodies.

Neurologic clinics
2025

Chronic Inflammatory Demyelinating Polyneuropathy and Variants.

Neurologic clinics
2025

Innate Immunity in the Pathogenesis of Selected Autoimmune Neurological Diseases.

Journal of clinical medicine
2025

Motor and Cognitive Fatigue in Chronic Inflammatory Demyelinating Polyneuropathy.

European journal of neurology
2026

Nerve Ultrasound in Pediatric Polyneuropathies: A Systematic Review.

Neuropediatrics
2025

Chimeric Antigen Receptor (CAR) T Cell Therapy for Neuromuscular Disorders: A Systematic Review.

Cureus
2025

Coexistence of Acute Demyelinating Polyneuropathy and LRP4-Positive Myasthenia Gravis.

Case reports in neurological medicine
2025

A Rare Case of Concomitant Fibrillary Glomerulonephritis and Membranous Nephropathy in a Patient With Chronic Inflammatory Demyelinating Polyneuropathy.

Cureus
2025

Chronic inflammatory demyelinating polyneuropathy (CIDP) after cilta-cel therapy.

Blood cancer journal
2025

[A case of adult-onset Krabbe disease diagnosed by galactocerebrosidase gene mutations, presenting with an atypical phenotype].

Rinsho shinkeigaku = Clinical neurology
2025

Anti-pan-neurofascin IgG3: insights about an emerging autoimmune nodoparanodopathy.

Arquivos de neuro-psiquiatria
2025

Clinical Spectrum, Pathology, and Mechanisms of Anti-LGI4 Antibody-Positive Autoimmune Nodopathy.

Neurology(R) neuroimmunology &amp; neuroinflammation
2025

Exacerbation of demyelinating polyneuropathy after adoptive cell therapy with tumour-infiltrating lymphocytes by metastatic melanoma.

Swiss medical weekly
2025

Efficacy of Tacrolimus Plus Prednisone as Long-Term Immunosuppressive Therapy for Chronic Inflammatory Demyelinating Polyneuropathy: A Retrospective Cohort Study.

ImmunoTargets and therapy
2025

Temporal Association Between Dengue Outbreaks and Neurologic Autoimmune Diseases in French Guiana.

Neurology(R) neuroimmunology &amp; neuroinflammation
2025

Hereditary Neuropathy with Liability to Pressure Palsies Mimicking a Chronic Inflammatory Demyelinating Polyneuropathy Variant: A Case Report Highlighting Diagnostic Challenges.

Internal medicine (Tokyo, Japan)
2025

Comparison of the presentation and electrophysiological characteristics of autoimmune nodopathies in patients with antibody-negative CIDP and CMT1.

Frontiers in neurology
2025

Impact of Physical Exercise Programs on Fatigue and Functional Capacity in People With Guillain-Barré Syndrome and Chronic Inflammatory Demyelinating Polyneuropathy: A Systematic Review.

Archives of physical medicine and rehabilitation
2025

A Novel Cause of CIDP: Homozygous Hotspot Mutation, c.793 C > T in CASP8 Gene.

Journal of clinical immunology
2025

Development of a PROM set for patients with Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyneuropathy (CIDP): study protocol.

Health and quality of life outcomes
2025

Atypical diabetic neuropathies.

BMJ (Clinical research ed.)
2025

Polyradiculoneuropathies associated with immune checkpoint inhibitors: are we facing a new nosological entity?

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2025

Epidemiology, Presentation, Management and Outcomes in Chronic Inflammatory Demyelinating Polyneuropathy in Birmingham, UK: The Impact of Ethnicity.

Journal of the peripheral nervous system : JPNS
2025

POEMS Syndrome Without a Detectable Monoclonal Peak: The Critical Role of VEGF and Bone Marrow Biopsy in Diagnosis.

Case reports in hematology
2025

Humoral Immune Response Following COVID-19 Vaccination in Multifocal Motor Neuropathy and Chronic Inflammatory Demyelinating Polyneuropathy.

Vaccines
2026

Orbital apex-like syndrome with multiple cranial neuropathies secondary to chronic inflammatory demyelinating polyneuropathy.

Orbit (Amsterdam, Netherlands)
2025

Feasibility of Outpatient Transforaminal Lumbar Interbody Fusion (TLIF) in Chronic Inflammatory Demyelinating Polyneuropathy: A Case Report.

Cureus
2025

Plasma lipidomic patterns associated with disease activity in chronic inflammatory demyelinating polyradiculoneuropathy (LIPID-CIDP).

Journal of lipid research
2025

Complement profiling of sural nerves in chronic-inflammatory demyelinating polyneuropathy.

Acta neuropathologica
2025

Feasibility of Subcutaneous Immunoglobulin Therapy as the Maintenance Therapy in Patients with Autoimmune Neuromuscular Disease: A Prospective Study.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
2025

Natural Pregnancy Following Oocyte Retrieval in a Luteal-Phase Progestin-Primed Ovarian Stimulation (PPOS) Protocol With Concurrent Blastocyst Cryopreservation: A Case Report.

Cureus
2025

Neuronal inflammation-associated biomarkers in cerebrospinal fluid of patients with acute and chronic inflammatory demyelinating polyneuropathies.

Journal of neuroimmunology
2025

Targeting BCMA in CIDP: Valuable insights gained through multi-omics immune monitoring.

Med (New York, N.Y.)
2025

Autologous haematopoietic stem cell transplantation in non-MS neuroimmunological diseases.

Multiple sclerosis and related disorders
2025

5-Aminolevulinic Acid Ameliorates Chronic Experimental Autoimmune Neuritis Through a Dual Mechanism of Mitochondrial Protection and Immunomodulation.

International journal of molecular sciences
2025

POEMS Syndrome Masquerading as Metastatic Prostate Cancer Based on PSMA Avid Lesions.

Case reports in hematology
2025

A new screening tool for early recognition of ATTRv polyneuropathy in clinical practice: AmyloScan®.

Journal of neurology
2025

Quality of Life in Patients with Chronic Inflammatory Demyelinating Neuropathies Treated with Subcutaneous Immunoglobulin.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
2025

[AQP4 positive neuromyelitis optica spectrum disorder: an atypical pathology with nerve root enlargement and peripheral nervous system damage in demyelination].

Rinsho shinkeigaku = Clinical neurology
2025

Outcome measures in CIDP: A scoping and mapping review.

Journal of the neurological sciences
2025

B Cell Tolerance and BCR Signaling Dysregulation in NF155-Mediated Autoimmune Nodopathies.

bioRxiv : the preprint server for biology
2025

Real-World Multinational Survey of Chronic Inflammatory Demyelinating Polyneuropathy: Disease Characteristics and Therapeutic Landscape.

Journal of the peripheral nervous system : JPNS
2026

Tipping the balance: the PD1-axis as a modulator in chronic inflammatory demyelinating polyneuropathy.

Brain : a journal of neurology
2025

Childhood POLG-related disorders: Focus on polyradiculoneuropathy.

Molecular genetics and metabolism
2025

Impact of Social Deprivation on Diagnosis, Management and Outcome of Chronic Inflammatory Demyelinating Polyneuropathy at a Tertiary UK Centre.

Journal of the peripheral nervous system : JPNS
2025

Chronic inflammatory demyelinating polyneuropathy complicated by pre-eclampsia progressing to HELLP syndrome and pulmonary embolism: A case report.

Case reports in women's health
2025

Random X chromosome inactivation in female Charcot-Marie-Tooth disease type X1: insights from sural nerve biopsy analysis.

BMC neurology
2025

CAR T-cells meet autoimmune neurological diseases: a new dawn for therapy.

Frontiers in immunology
2025

Clinical and Genetic Reassessment in Patients With Clinically Diagnosed Hereditary Polyneuropathy.

European journal of neurology
2025

Controversies in the diagnosis of chronic inflammatory demyelinating polyneuropathy.

Current opinion in neurology
2025

An auxiliary diagnostic strategy for distinguishing Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy: combining platelet-to-lymphocyte ratio and cerebrospinal fluid interleukin-8 levels.

BMC neurology
2025

Genetic susceptibility of human leukocyte antigen alleles in chronic inflammatory demyelinating polyneuropathy in Korean patients : Short title: HLA alleles and CIDP in Korea.

BMC neurology
2025

Minimal Clinically Important Differences in Measuring Treatment Effects in CIDP: History, Current Use, Limitations, and Prospects.

Muscle &amp; nerve
2025

Exploring Ultrasonographic Atypical Aspects in Drug-Resistant Multifocal Chronic Inflammatory Demyelinating Polyneuropathy.

Brain and behavior
2025

Extracorporeal therapy procedures (plasma exchange and immunoadsorption) in chronic inflammatory demyelinating polyneuropathies (CIDP)- a database analysis.

BMC neurology
2025

Digital biomechanical assessment of gait in patients with peripheral neuropathies.

Journal of neuroengineering and rehabilitation
2026

Blood bile acid profiles in chronic inflammatory demyelinating polyneuropathy.

Clinica chimica acta; international journal of clinical chemistry
2025

Nervous Breakdown: Chronic Inflammatory Demyelinating Polyneuropathy as an Extra-Intestinal Manifestation of Ulcerative Colitis.

Digestive diseases and sciences
2025

Digital Activity Markers in Chronic Inflammatory Demyelinating Polyneuropathy.

Annals of clinical and translational neurology
2026

Nerve conduction study and nerve ultrasound as biomarkers for steroid dependence in chronic inflammatory demyelinating polyneuropathy.

Neurological research
2025

Electrophysiological-based automatic subgroups diagnosis of patients with chronic dysimmune polyneuropathies.

Journal of neuroengineering and rehabilitation
2025

Whole-Body Magnetic Resonance Neurography-Technique, Current Perspectives, and Future Directions.

Magnetic resonance imaging clinics of North America
2025

Where Does It All Itch? Exploring the Characteristics of Pruritus in Small Fiber Neuropathy.

Journal of the peripheral nervous system : JPNS
2025

Comparison of imaging markers of nerve ultrasound and MR-neurography in a longitudinal course in chronic inflammatory demyelinating polyneuropathy.

Therapeutic advances in neurological disorders
2025

Case Report: Post-surgical Guillain-Barré syndrome as a rare differential diagnosis of flaccid paralysis of the lower extremities in an infant after cardiac surgery.

Frontiers in pediatrics
2025

Stiff tongue syndrome and multifocal immune neuropathy in a young man with anti-glutamic acid decarboxylase and unclassified antibodies.

BMJ case reports
2025

Chronic Inflammatory Demyelinating Polyneuropathy and Concurrent Membranous Nephropathy Associated With Anti-Contactin-1 Autoantibodies: A Rare Case Report With a Review of the Literature.

Cureus
2025

Chronic inflammatory demyelinating polyneuropathy in end-stage renal disease patients: a case series study.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2025

Nerve Ultrasound of Multifocal Motor Neuropathy and Motor and Typical Chronic Inflammatory Demyelinating Neuropathy.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
2025

Systematic Review: Mental Health Outcomes in Guillain-Barré Syndrome and Chronic Inflammatory Demyelinating Polyneuropathy.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
2025

Serum Neurofilament Light Chain as a Biomarker for CIDP Diagnosis, Severity, and Treatment Outcome.

Neurology(R) neuroimmunology &amp; neuroinflammation
2025

Inverse relation between serum neurofilament light chain and cognitive function in chronic inflammatory demyelinating polyneuropathy.

Journal of neurology
2025

Severe Worsening of Neuropathy Associated With Antibodies Against Myelin-Associated Glycoprotein by Rituximab Resembling Chronic Inflammatory Demyelinating Polyneuropathy.

Cureus
2025

Role of Imaging in Chronic Inflammatory Demyelinating Polyneuropathy: A Systematic Review.

European journal of neurology
2025

Peripheral neuropathies associated with anti-tnf-α treatments: a systematic review and proposed recommendations.

Journal of neurology
2025

A highly sensitive quantitative method of polysialic acid reveals its unique changes in brain aging and neuropsychiatric disorders.

Scientific reports
2025

Sulfatide antibody-mediated neuropathy: an analysis of clinical characteristics and immunotherapeutic responses.

Neurological research
2025

Objective assessments for walking aid prescription in balance impairment and falls risk: a scoping review of current evidence.

Disability and rehabilitation. Assistive technology
2025

Anti-BCMA CAR-T cell therapy in relapsed/refractory chronic inflammatory demyelinating polyneuropathy.

Med (New York, N.Y.)
2025

Validity and Responsiveness of Balance Measurements Using Posturography in Patients With Immune-Mediated Neuropathies.

Journal of the peripheral nervous system : JPNS
2025

Whipple Disease Initial Presentation as Supraclavicular Lymphadenopathy in a Patient With Rheumatoid Arthritis: A Diagnostic Challenge.

International journal of surgical pathology
2025

Focal Chronic Inflammatory Demyelinating Polyneuropathy - A Case Report with Clinical Application and Validation of 2021 European Academy of Neurology/Peripheral Nerve Society Criteria.

Acta neurologica Taiwanica
2025

Chronic Inflammatory Demyelinating Polyneuropathy: How Pathophysiology Can Guide Treatment.

Muscle &amp; nerve
2025

Case Report: A case of subacute combined degeneration of the spinal cord associated with chronic atrophic gastritis, macrocytic anemia, and positive anti-sulfatide IgM and IgG antibodies.

Frontiers in immunology
2025

Chronic Inflammation: A Multidisciplinary Analysis of Shared Pathways in Autoimmune, Infectious, and Degenerative Diseases.

Cureus
2025

Reviewer Comment on Li et al.: "Systematic review: mental health outcomes in Guillain-Barre syndrome and chronic inflammatory demyelinating polyneuropathy".

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
2025

Patient-Reported Outcome Measures for Assessing Health-Related Quality of Life in Patients With Polyneuropathies, Focusing on Guillain-Barré Syndrome and Chronic Inflammatory Demyelinating Polyneuropathy: A Systematic Review of Measurement Properties.

Journal of the peripheral nervous system : JPNS
2025

Chronic Inflammatory Demyelinating Polyneuropathy Following Natural Influenza A Infection in a Pediatric Patient: A Case Report and Literature Review.

Case reports in neurological medicine
2025

Syncope and New-Onset Bifascicular Block Associated With Intravenous Immunoglobulin in a Patient With Chronic Inflammatory Demyelinating Polyneuropathy.

Cureus
2025

Patient Experience of Chronic Inflammatory Demyelinating Polyneuropathy (CIDP): A Qualitative Exploration of Signs, Symptoms, and Health-Related Quality of Life Impacts.

Neurology and therapy
2025

Incomplete Presentations in Typical Chronic Inflammatory Demyelinating Polyneuropathy: A Single-Center, Retrospective Study.

Muscle &amp; nerve
2025

Plasma cell myeloma with an evolving diagnostic complexity: A case report.

Oncology letters
2025

A Rare Presentation of Patient With CIDP Found to Have Respiratory Failure and Encephalopathy.

Case reports in critical care
2025

Unmasking the mimic: Leprosy neuropathy misdiagnosed as chronic inflammatory demyelinating polyneuropathy: A case report from Saudi Arabia.

Neurosciences (Riyadh, Saudi Arabia)
2025

Acute-onset chronic inflammatory demyelinating polyneuropathy in a 23-year-old male exacerbated by an asymptomatic COVID-19 infection.

Current research in translational medicine
2025

Ultrasound Shear Wave Velocity of Peripheral Nerves: A Possible Non-Invasive Biomarker for Demyelinating Neuropathies.

Journal of the peripheral nervous system : JPNS
2025

Dantrolene for the Treatment of Chronic Inflammatory Demyelinating Polyneuropathy-Induced Painful Muscle Spasms: A Case Report.

A&amp;A practice
2025

[Rapidly progressive muscle weakness in anti-myelin associated glycoprotein (MAG) neuropathy successfully treated with intravenous immunoglobulin].

Rinsho shinkeigaku = Clinical neurology
2025

Successfully salvaging a HIV-positive patient with mixed CIDP and meningoencephalitis: a case report.

Frontiers in medicine
2025

Repeated clear benefits of immunotherapy in a patient with Charcot-Marie-Tooth disease carrying a rare point mutation in PMP22.

Neurogenetics
2025

Tracing a Rare Genetic Disease: Familial Congenital CD59 Deficiency and Carrier Cases Identified Through Village Screening.

Journal of pediatric hematology/oncology
2025

Rare Case of Sjögren's Syndrome with Chronic Inflammatory Demyelinating Polyneuropathy and Atrioventricular Block.

Annals of Indian Academy of Neurology
2025

Evaluating Grasp Function in Patients With Chronic Inflammatory Demyelinating Polyneuropathy Using Dynamometers: A Comprehensive Review.

Journal of clinical medicine research
2025

Feasibility and Reliability of a Monitoring App for Chronic Inflammatory Neuropathies.

Journal of the peripheral nervous system : JPNS
2025

Utility of Median Nerve Electrophysiological Parameters in Differentiating Immune-Mediated Demyelination From Compressive Median Neuropathy at the Wrist.

Muscle &amp; nerve
2025

Impact of the COVID-19 pandemic on the mental and physical wellbeing of patients with motor neuron disease and other neuromuscular disease.

Frontiers in neurology
2025

Diagnosis of hereditary transthyretin amyloidosis in patients with suspected chronic inflammatory demyelinating polyneuropathy unresponsive to intravenous immunoglobulins: results of a retrospective study.

Orphanet journal of rare diseases
2025

Eculizumab as a Disease-Modifying Therapy in Chronic Inflammatory Demyelinating Polyneuropathy (CIDP): A Case Report.

Journal of the peripheral nervous system : JPNS
2025

Clinical characteristics of Guillain-Barré syndrome in Shenzhen: a retrospective study.

BMC neurology
2025

Spinal cord stimulation (SCS) induced favorable neuromodulative outcome in the treatment of chronic neuropathic pain syndrome in children.

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
2025

Unique Nerve Tissue-Restricted T-Cell Clones in Chronic Inflammatory Demyelinating Polyneuropathy.

Journal of the peripheral nervous system : JPNS
2025

Chronic Inflammatory Demyelinating Polyneuropathy: A Narrative Review of a Systematic Diagnostic Approach to Avoid Misdiagnosis.

Cureus
2025

Association Between MScanFit Motor Unit Number Estimation and Clinical Function and Response to Immunoglobulin Therapy in Chronic Inflammatory Demyelinating Polyneuropathy.

Journal of the peripheral nervous system : JPNS
2025

Chronic inflammatory demyelinating polyneuropathy associated with active systemic lupus erythematous: Anifrolumab as a potentially successful add-on therapy to intravenous immunoglobulins.

Lupus
2025

[Neurology: what's new in 2024].

Revue medicale suisse
2025

Distinguishing Chronic Inflammatory Demyelinating Polyneuropathy From Mimic Disorders: The Role of Statistical Modeling.

Journal of the peripheral nervous system : JPNS
2025

The overlap of diabetic and inflammatory neuropathies: Epidemiology, possible mechanisms, and treatment implications.

Clinical neurology and neurosurgery
2025

Magnetic resonance imaging in chronic inflammatory demyelinating polyneuropathy (CIDP): Brachial plexus, lumbosacral plexus, and cranial nerve involvement.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
2025

Clinical and Electrophysiological Characteristics of 23 French Patients With Neurolymphomatosis.

Muscle &amp; nerve
Ver todos os 1.138 no EuropePMC

Associações

Organizações que acompanham esta doença — pra ter apoio e orientação

Ainda não temos associações cadastradas para Polineuropatia desmielinizante inflamatória crônica.

É de uma associação que acompanha esta doença? Fale com a gente →

Doença com base genética

Um médico geneticista pode ajudar no diagnóstico de Polineuropatia desmielinizante inflamatória crônica e no aconselhamento genético da família.

Vai consultar um especialista? Confirme o registro dele no conselho.
Conselhos e sociedades

Doenças relacionadas

Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico

Ordenadas pelo número de sintomas em comum.

Perguntas frequentes

O que as famílias mais perguntam sobre esta doença — cada resposta com a fonte de onde saiu

Respostas geradas por IA a partir das fontes citadas

CIDP é a sigla em inglês para polineuropatia desmielinizante inflamatória crônica. Trata-se de um distúrbio neurológico que acomete a mielina dos nervos periféricos.

Referências

Fontes citadas no texto, publicações do grafo e bases de dados usadas neste verbete

10 publicações do grafo RarasNet (PubMed) · 5 bases de dados. Títulos, periódicos e PMIDs vêm direto da fonte, sem intermediação de IA.

  1. The actual usefulness of culturing apheresis products in hematopoietic stem cell autotransplants.
    Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis2026PMID 41687157
  2. ORPHA:2932
    Orphanet
  3. GARD:6102
    GARD (NIH)
  4. Q1088030
    Wikidata

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Citar este verbete

Raras. (s.d.). Polineuropatia desmielinizante inflamatória crônica. Em Raras — Enciclopédia de Doenças Raras do Brasil. https://raras.org/doenca/polineuropatia-desmielinizante-inflamatoria-cronica

Formato APA. Conteúdo sob CC BY 4.0 — reuso livre com atribuição.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Polineuropatia desmielinizante inflamatória crônica
Compêndio · Raras BR

Polineuropatia desmielinizante inflamatória crônica

ORPHA:2932 · MONDO:0006702
🇧🇷 Brasil SUS
SIGTAP
2 procedimentos
Geral
Prevalência
1-9 / 100 000
Herança
Not applicable
CID-10
G61.8 · Outras polineuropatias inflamatórias
CID-11
Ensaios
56 ativos
Início
Adolescent, Adult, Childhood, Elderly
Prevalência
3.7 (Europe)
MedGen
UMLS
C0393819
EuropePMC
Wikidata
Papers 10a
Evidência
🥈 Ensaio clínico

📋 Origem dos dados

Esta página agrega dados de fontes públicas e oficiais. Dados sobre cobertura no SUS (PCDT, CEAF) são verificados ativamente por agente proativo (ver badge no infobox). Demais dados têm atribuição de fonte + data da última sincronização — clique para abrir o original.

Doença rara (ontologia)
fonte: Orphanet
Identificador unificado
fonte: MONDO
Indexação biomédica
fonte: MeSH (NLM)
Dado público estruturado
fonte: Wikidata
Medicamentos aprovados FDA
fonte: FDA OpenFDA
Rara