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Pré-eclâmpsia
ORPHA:275555CID-10 · O14.2CID-11 · JA24DOENÇA RARA

A pré-eclâmpsia é um distúrbio hipertensivo da gravidez caracterizado por hipertensão de início recente com proteinúria que se manifesta após 20 semanas de gestação e, dependendo das formas leves ou graves, pode inicialmente apresentar cefaleia intensa, distúrbios visuais e hiperreflexia.

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Introdução

O que você precisa saber de cara

📋

A pré-eclâmpsia é um distúrbio hipertensivo da gravidez caracterizado por hipertensão de início recente com proteinúria que se manifesta após 20 semanas de gestação e, dependendo das formas leves ou graves, pode inicialmente apresentar cefaleia intensa, distúrbios visuais e hiperreflexia.

Pesquisas ativas
22 ensaios
932 total registrados no ClinicalTrials.gov
Publicações científicas
46.382 artigos
Último publicado: 2026 Mar

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
1-5 / 10 000
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
45.0
Europe
Início
Adult
🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: O14.2
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Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🩸
Sangue
6 sintomas
🫘
Rins
5 sintomas
🫃
Digestivo
5 sintomas
📏
Crescimento
3 sintomas
🛡️
Imunológico
2 sintomas
🧠
Neurológico
2 sintomas

+ 24 sintomas em outras categorias

Características mais comuns

90%prev.
Pressão arterial sistólica elevada
Muito frequente (99-80%)
90%prev.
Pressão arterial diastólica elevada
Muito frequente (99-80%)
90%prev.
Hipertensão
Muito frequente (99-80%)
90%prev.
Morfologia anormal da placenta
Muito frequente (99-80%)
90%prev.
Proteinúria
Muito frequente (99-80%)
55%prev.
Insuficiência renal
Frequente (79-30%)
50sintomas
Muito frequente (5)
Frequente (3)
Ocasional (10)
Muito raro (9)
Sem dados (23)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 50 características clínicas mais associadas, ordenadas por frequência.

Pressão arterial sistólica elevadaElevated systolic blood pressure
Muito frequente (99-80%)90%
Pressão arterial diastólica elevadaElevated diastolic blood pressure
Muito frequente (99-80%)90%
HipertensãoHypertension
Muito frequente (99-80%)90%
Morfologia anormal da placentaAbnormality of the placenta
Muito frequente (99-80%)90%
ProteinúriaProteinuria
Muito frequente (99-80%)90%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico46.382PubMed
Últimos 10 anos200publicações
Pico2026194 papers
Linha do tempo
2026Hoje · 2026🧪 1987Primeiro ensaio clínico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

Genes associados

7 genes identificados com associação a esta condição. Padrão de herança: Not applicable.

CORINAtrial natriuretic peptide-converting enzymeMajor susceptibility factor inTolerante
FUNÇÃO

Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) and brain natriuretic peptide (NPPB) processing (PubMed:10880574, PubMed:20489134, PubMed:21288900, PubMed:21763278). Converts through proteolytic cleavage the non-functional propeptides NPPA and NPPB into their active hormones, ANP and BNP(1-32) respectively, thereby regulating blood pressure in the heart and promoting natriuresis, diuresis and vasodilation (PubMed:10880574, PubMed:20489134, PubMed:21288900, PubMed:21763278

LOCALIZAÇÃO

Cell membraneSecreted

VIAS BIOLÓGICAS (1)
Physiological factors
MECANISMO DE DOENÇA

Pre-eclampsia/eclampsia 5

A hypertensive disorder of pregnancy characterized by new hypertension (blood pressure 140/90 or greater) presenting after 20 weeks' gestation with clinically relevant proteinuria. It impacts 2 individuals, the mother and her child, both of whom can be severely affected. Preeclampsia is one of the causes of maternal mortality and morbidity worldwide.

VIAS REACTOME (1)
INTERAÇÕES PROTEICAS (1)
OUTRAS DOENÇAS (3)
cardiomyopathy, familial hypertrophic, 30, atrialpreeclampsia/eclampsia 5preeclampsia
HGNC:19012UniProt:Q9Y5Q5
CFIComplement factor ICandidate gene tested inTolerante
FUNÇÃO

Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three peptide bonds in the alpha-chain of C3b and two bonds in the alpha-chain of C4b thereby inactivating these proteins (PubMed:17320177, PubMed:7360115). Essential cofactors for these reactions include factor H and C4BP in the fluid phase and membrane cofactor protein/CD46 and CR1 on cell surfaces (PubMed:12055245, PubMed:21418

LOCALIZAÇÃO

Secreted, extracellular spaceSecreted

VIAS BIOLÓGICAS (1)
Regulation of Complement cascade
MECANISMO DE DOENÇA

Hemolytic uremic syndrome, atypical, 3

An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease.

OUTRAS DOENÇAS (6)
complement factor I deficiencyDoyne honeycomb retinal dystrophyatypical hemolytic uremic syndrome with complement gene abnormalityHELLP syndrome
HGNC:5394UniProt:P05156
HELLPARCandidate gene tested inDesconhecido
LOCALIZAÇÃO

OUTRAS DOENÇAS (1)
HELLP syndrome
HGNC:43984
CFHComplement factor HCandidate gene tested inAltamente restrito
FUNÇÃO

Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces (PubMed:21285368, PubMed:21317894, PubMed:25402769). Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of

LOCALIZAÇÃO

Secreted

VIAS BIOLÓGICAS (1)
Regulation of Complement cascade
MECANISMO DE DOENÇA

Basal laminar drusen

Drusen are extracellular deposits that accumulate below the retinal pigment epithelium on Bruch membrane. Basal laminar drusen refers to an early adult-onset drusen phenotype that shows a pattern of uniform small, slightly raised yellow subretinal nodules randomly scattered in the macula. In later stages, these drusen often become more numerous, with clustered groups of drusen scattered throughout the retina. In time these small basal laminar drusen may expand and ultimately lead to a serous pigment epithelial detachment of the macula that may result in vision loss.

OUTRAS DOENÇAS (10)
complement factor H deficiencybasal laminar drusendense deposit diseaseDoyne honeycomb retinal dystrophy
HGNC:4883UniProt:P08603
CD46Membrane cofactor proteinCandidate gene tested inTolerante
FUNÇÃO

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent auto

LOCALIZAÇÃO

Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane

VIAS BIOLÓGICAS (1)
Regulation of Complement cascade
MECANISMO DE DOENÇA

Hemolytic uremic syndrome, atypical, 2

An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease.

OUTRAS DOENÇAS (3)
HELLP syndromeatypical hemolytic uremic syndrome with complement gene abnormalityatypical hemolytic-uremic syndrome with MCP/CD46 anomaly
HGNC:6953UniProt:P15529
FLT1Vascular endothelial growth factor receptor 1Major susceptibility factor inAltamente restrito
FUNÇÃO

Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (By similarity). May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothe

LOCALIZAÇÃO

Cell membraneEndosomeSecretedCytoplasm

VIAS BIOLÓGICAS (2)
VEGF binds to VEGFR leading to receptor dimerizationNeurophilin interactions with VEGF and VEGFR
EXPRESSÃO TECIDUAL(Ubíquo)
Tireoide
54.2 TPM
Adipose Visceral Omentum
35.7 TPM
Tecido adiposo
28.6 TPM
Pulmão
25.4 TPM
Mama
25.3 TPM
OUTRAS DOENÇAS (1)
preeclampsia
HGNC:3763UniProt:P17948
STOX1Storkhead-box protein 1Major susceptibility factor inTolerante
FUNÇÃO

Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta (PubMed:24738702). Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway (By similarity) Involved in cell cycle regulation by binding to the CCNB1 promoter, up-regulating its expression and promoting mitotic entry (PubMed:22253775). Induces phosphorylation of MAPT/tau (PubMed:22995177)

LOCALIZAÇÃO

CytoplasmNucleusCytoplasm, cytoskeleton, microtubule organizing center, centrosomeNucleus, nucleolus

MECANISMO DE DOENÇA

Pre-eclampsia/eclampsia 4

A hypertensive disorder of pregnancy characterized by new hypertension (blood pressure 140/90 or greater) presenting after 20 weeks' gestation with clinically relevant proteinuria. It impacts 2 individuals, the mother and her child, both of whom can be severely affected. Preeclampsia is one of the causes of maternal mortality and morbidity worldwide.

EXPRESSÃO TECIDUAL(Ubíquo)
Brain Anterior cingulate cortex BA24
18.9 TPM
Cérebro - Amígdala
17.8 TPM
Córtex cerebral
17.7 TPM
Brain Frontal Cortex BA9
16.8 TPM
Brain Nucleus accumbens basal ganglia
16.5 TPM
OUTRAS DOENÇAS (2)
preeclampsia/eclampsia 4preeclampsia
HGNC:23508UniProt:Q6ZVD7

Medicamentos aprovados (FDA)

3 medicamentos encontrados nos registros da FDA americana.

💊 Magnesium Sulfate in Dextrose (MAGNESIUM SULFATE IN DEXTROSE)
💊 Magnesium Sulfate in Water (MAGNESIUM SULFATE IN WATER)
💊 Magnesium Sulfate (MAGNESIUM SULFATE IN WATER FOR)
Ver no DailyMed/FDA

Variantes genéticas (ClinVar)

242 variantes patogênicas registradas no ClinVar.

🧬 CORIN: NM_006587.4(CORIN):c.800-3del ()
🧬 CORIN: NM_006587.4(CORIN):c.2004_2005del (p.Ser669fs) ()
🧬 CORIN: GRCh37/hg19 4p16.3-11(chr4:68345-49089361)x3 ()
🧬 CORIN: GRCh37/hg19 4p12-q35.2(chr4:45455621-191003541)x3 ()
🧬 CORIN: GRCh38/hg38 4p16.3-q12(chr4:85624-57073230)x3 ()
Ver todas no ClinVar

Classificação de variantes (ClinVar)

Distribuição de 68 variantes classificadas pelo ClinVar.

15
38
15
Patogênica (22.1%)
VUS (55.9%)
Benigna (22.1%)
VARIANTES MAIS SIGNIFICATIVAS
CORIN: NM_006587.4(CORIN):c.8dup (p.Ser4fs) [Conflicting classifications of pathogenicity]
NSD1: NM_022455.5(NSD1):c.6050G>A (p.Arg2017Gln) [Pathogenic/Likely pathogenic]
STOX1: NM_152709.5(STOX1):c.2195G>A (p.Cys732Tyr) [Uncertain significance]
STOX1: NM_152709.5(STOX1):c.1750A>G (p.Ser584Gly) [Uncertain significance]
STOX1: NM_152709.5(STOX1):c.1450G>C (p.Gly484Arg) [Uncertain significance]

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
Aprovado2
3Fase 31
2Fase 22
1Fase 12
·Pré-clínico13
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 20 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Pré-eclâmpsia

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

🟢 Recrutando agora

13 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

Outros ensaios clínicos

932 ensaios clínicos encontrados, 22 ativos.

Distribuição por fase
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

📖Melhor nível de evidência: Revisão
Timeline de publicações
25.900 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 25.900

#1

Research progress on histone epigenetic modifications in placental trophoblast syncytialization.

Life sciences2026 Mar 21

Este artigo destaca que a pré-eclâmpsia e outras doenças da gravidez estão associadas a falhas na formação da placenta, especialmente na fusão de suas células (sincicialização). Este processo crucial é finamente regulado por modificações epigenéticas, e a disfunção nessas regulagens é um fator chave no surgimento das complicações. Compreender essas alterações oferece grande potencial para o desenvolvimento de novos métodos de diagnóstico precoce e terapias mais eficazes, beneficiando diretamente pacientes e médicos no manejo da pré-eclâmpsia.

🇧🇷 traduzido
#2

Leveraging PANoptosis-associated genes for unraveling implication of decidualization deficiency in pre-eclampsia via transcriptome data and experiment validation.

Frontiers in cell and developmental biology2026

Este estudo revela que a pré-eclâmpsia está associada à deficiência de decidualização e a uma forma de morte celular inflamatória chamada PANoptosis. Foram identificados genes específicos relacionados à PANoptosis que podem servir como biomarcadores para o diagnóstico precoce da doença. Além disso, a melatonina emergiu como um candidato terapêutico promissor, demonstrando efeitos protetores como melhora da pressão arterial e restauração parcial da decidualização, ao modular essas vias.

🇧🇷 traduzido
#3

Long-term cardiac consequences of fetal exposure to preeclampsia: a speckle tracking echocardiography analysis.

European journal of pediatrics2026 Mar 20

Este estudo mostra que crianças expostas à pré-eclâmpsia no útero apresentam alterações sutis na função cardíaca (sistólica e diastólica), que não são identificadas em exames de ecocardiograma convencionais. Essas disfunções sublícnicas são detectadas apenas por métodos avançados, como a ecocardiografia com *speckle tracking* 2D. Assim, para médicos e pacientes, é crucial o monitoramento cardíaco a longo prazo com essa técnica especializada para essa população de risco, a fim de identificar e acompanhar precocemente potenciais problemas cardiovasculares, independentemente do tipo de pré-eclâmpsia.

🇧🇷 traduzido
#4

Hypertension action bundle including training of healthcare professionals to improve the detection of primary aldosteronism: a cohort study.

Blood pressure2026 Mar 19

Este estudo demonstrou que um programa de treinamento para profissionais de saúde, incluindo clínicos gerais, cardiologistas e ginecologistas, aumentou significativamente (em cerca de quatro vezes) a detecção do hiperaldosteronismo primário (HAP), uma causa tratável e frequentemente subdiagnosticada de hipertensão. A melhora na identificação do HAP ocorreu porque os médicos passaram a rastrear a doença em perfis menos comuns, como pacientes jovens, com hipertensão refratária ou com histórico de pré-eclâmpsia. Essa abordagem multidisciplinar é crucial para que mais pacientes com HAP recebam o diagnóstico e o tratamento específico, essencial para controlar a pressão arterial e reduzir os riscos cardiovasculares.

🇧🇷 traduzido
#5

Persistent entropy links irregularities in daily and weekly rest and activity cycles during gestation week 22 and 32 to maternal and neonate health outcomes: A prospective cohort study.

PloS one2026

Um estudo recente sugere que padrões diários de repouso e atividade muito irregulares, medidos por uma nova técnica chamada "entropia persistente" durante a gravidez (semanas 22 e 32), estão associados a um risco significativamente maior de complicações maternas e neonatais, incluindo pré-eclâmpsia. Tais irregularidades, especialmente na semana 22 e mais acentuadamente em gestantes com IMC elevado, podem ter valor preditivo, indicando que monitorar a consistência do ciclo de repouso-atividade pode ser uma ferramenta útil para identificar riscos. Contudo, são necessários estudos maiores para confirmar esses achados e avaliar seu uso clínico como ferramenta de rastreamento.

🇧🇷 traduzido

Publicações recentes

Ver todas no PubMed

📚 EuropePMC16.307 artigos no totalmostrando 195

2026

Bariatric Surgery, Gestational Diabetes and Perinatal Outcomes: A Population-Based Study.

BJOG : an international journal of obstetrics and gynaecology
2026

Isolated hypoglossal nerve mononeuropathy associated with preeclampsia in late pregnancy: a case report.

Journal of medical case reports
2026

Effects of Nutritional Supplement Intake on Pregnancy Outcomes in Overweight and Obese Women: A Systematic Review and Meta-Analysis.

The journal of obstetrics and gynaecology research
2026

"Letter to Editor regarding 'Maternal, fetal, and neonatal serious adverse events associated with lowdose aspirin during the first trimester of pregnancy: A secondary analysis of the Aspirin Supplmentation for Pregnancy Indicated Risk Reduction In Nulliparas (ASPIRIN) trial"'.

American journal of obstetrics &amp; gynecology MFM
2026

Research progress on histone epigenetic modifications in placental trophoblast syncytialization.

Life sciences
2026

Disrupting the circTNC/miR-582-5p/MAPK8 axis alleviates oxidative stress-induced trophoblast dysfunction in preeclampsia.

Journal of molecular histology
2026

The expression and mechanism of action of MicroRNA-210 in preeclampsia.

Clinical and investigative medicine. Medecine clinique et experimentale
2026

Hydroxychloroquine-Use and Preeclampsia and Preterm Delivery Complications in Systemic Lupus Erythematosus Pregnancies: Is there a protective effect?

Arthritis care &amp; research
2026

Incidence and Predictors of Preeclampsia Among Pregnant Women With Urinary Tract Infection: A Prospective Observational Study.

Cureus
2026

Threshold-dependent effect of the neutrophil-to-albumin ratio (NAR) in early pregnancy: a novel insight for preeclampsia risk prediction.

American journal of translational research
2026

Periconceptional Folic Acid Supplementation and the Risk of Preeclampsia in Eastern Sudan: An Unmatched Case-Control Study.

International journal of women's health
2026

East Asian Mendelian-Randomization Evidence Linking PCOS to Gestational Diabetes Mellitus.

International journal of women's health
2026

Knowledge of Pre-Eclampsia and Its Risk Factors Among Pregnant Women Attending Antenatal Care in Lango Sub-Region, Northern Uganda.

International journal of women's health
2026

Nutritional Management in Pregnant Women with Preeclampsia: A Scoping Review.

Journal of multidisciplinary healthcare
2026

2D Shear Wave Elastography: An Evolving Technique for Comparison of Placental Elasticity in Normal and Preeclamptic Pregnancy.

The Indian journal of radiology &amp; imaging
2026

Evaluation of Maternal Ophthalmic Artery Doppler Velocimetry at 18 to 24 Weeks of Gestational Age in the Prediction of Preeclampsia.

The Indian journal of radiology &amp; imaging
2026

Histone Acetyltransferase KAT14 Mediates CDH5 to Regulate Spiral Artery Remodeling in Preeclampsia via Cooperation With SRF.

Hypertension (Dallas, Tex. : 1979)
2026

Targeted delivery of RGD-JEG-3-EVs for placental vascular regeneration in preeclampsia: from molecular mechanism toward therapy.

Apoptosis : an international journal on programmed cell death
2026

Maternal hypertension and survival without bronchopulmonary dysplasia in preterm infants: a meta-analysis of cohort studies.

The journal of maternal-fetal &amp; neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
2026

Re-evaluating the clinical interpretation of sFlt-1/PlGF in diabetes-complicated preeclampsia.

Pregnancy hypertension
2026

The relationship between APOL1 risk variants and with preeclampsia and fetal outcomes.

Pregnancy hypertension
2026

Calcineurin inhibitors and the risk of preeclampsia in solid organ transplantation - Should we rethink our approach during pregnancy?

Pregnancy hypertension
2026

Construction of a diagnostic model for preeclampsia based on differentially expressed lactylation-related genes and the immune infiltration analysis.

Scientific reports
2026

First-trimester serum placental growth factor and risk of severe maternal morbidity and mortality.

American journal of obstetrics and gynecology
2026

Parameters of the thrombin generation test in pregnant women with preeclampsia: a systematic review.

BMC pregnancy and childbirth
2026

Emerging ultrasound-based imaging of the placenta during complications of pregnancy.

Placenta
2026

DECR1 deficiency activates a lipid peroxidation-mitocytosis-mitochondrial dysfunction axis in trophoblasts to promote preeclampsia.

Free radical biology &amp; medicine
2026

Gestational diabetes mellitus in low- and middle-income countries: a systematic review and meta-analysis of associated factors.

Diabetes research and clinical practice
2026

microRNA-155: a versatile noncoding RNA.

Molecular biology reports
2026

Lifetime Adverse Pregnancy Outcome History and Cardiovascular Risk.

Hypertension (Dallas, Tex. : 1979)
2026

Effects of Antihypertensive Therapy on Pre- and Postnatal Maternal Hemodynamics.

Hypertension (Dallas, Tex. : 1979)
2026

A Comparative Cross-Sectional Study Between Gestational Diabetes Mellitus and Preeclampsia: Medication Adherence, Depression and Quality of Life.

International journal of women's health
2026

Beyond HELLP: An Unusual Cause of Severe Thrombocytopenia in Pregnancy.

Cureus
2026

Current Understanding on Hypertensive Disorders in Pregnancy.

International journal of general medicine
2026

Profound hyponatraemia in early-onset preeclampsia: a case report of a rare and complex presentation.

Case reports in women's health
2026

Leveraging PANoptosis-associated genes for unraveling implication of decidualization deficiency in pre-eclampsia via transcriptome data and experiment validation.

Frontiers in cell and developmental biology
2026

Nano-Enabled Therapeutics: Novel Strategies for Preeclampsia Treatment.

International journal of nanomedicine
2026

-Impact of first-trimester preeclampsia screening on perinatal and maternal morbidity: the RANSPRE open multicenter randomized trial.

BMC pregnancy and childbirth
2026

Comprehensive analysis of RNA sequencing reveals DNA damage response and immune-associated alternative splicing and RBP regulators contributing to preeclampsia.

BMC genomics
2026

Long-term cardiac consequences of fetal exposure to preeclampsia: a speckle tracking echocardiography analysis.

European journal of pediatrics
2026

Low-Dose Aspirin Recommendations for Preeclampsia Risk Reduction: A Systematic Review Focused on Black Patients : Current Hypertension Reports.

Current hypertension reports
2026

Leveraging the All of Us Research Program to Advance Women's Health: Addressing Conditions that Affect Women Differently, Disproportionately, and Uniquely.

Journal of women's health (2002)
2026

Comparison of 162 mg and 81 mg Aspirin for Prevention of Preeclampsia: A Randomized Controlled Trial.

Obstetrics and gynecology
2026

Integrative biology shows DPP4 affects inflammatory response to eclampsia and cell model growth via p65/NLRP3/ASC/Caspase-1 pathway.

Frontiers in genetics
2026

Hypertension action bundle including training of healthcare professionals to improve the detection of primary aldosteronism: a cohort study.

Blood pressure
2026

Halogenated phenolic disinfectants suppress 11β-hydroxysteroid dehydrogenase 2 activity in human and rat models: Experimental and computational evidence.

The Journal of steroid biochemistry and molecular biology
2026

The influence of labor and gestational age on maternal IL-6 and IL-10 plasma levels in preeclampsia.

Journal of reproductive immunology
2026

Determining the desired concentration of a nutraceutical based on the variation of its concentration with the incidence of a disease: application to ergothioneine and pre-eclampsia.

Pregnancy hypertension
2025

Effect of Paracetamol on Blood Pressure: A Systematic Review.

La Tunisie medicale
2026

Placental Autophagy: Causes and Consequences.

Current opinion in physiology
2026

Effects of early vs. late administration of labetalol on maternal cerebral perfusion and fetal growth in severe pre-eclampsia.

Frontiers in medicine
2026

Transplantation and Mortality in Women After Delivering on Hemodialysis.

Kidney international reports
2026

Angiogenic imbalance and endothelial dysfunction in the placenta in antiphospholipid syndrome.

Autoimmunity reviews
2026

Calcium supplementation for prevention of pre-eclampsia in high-risk women: study protocol for a randomised triple-blind placebo-controlled trial (CaPE).

Trials
2026

The impact of pre-pregnancy body mass index and maternal diseases on the offspring outcomes in preterm infants < 32 weeks: five-year retrospective mediation analysis.

BMC pregnancy and childbirth
2026

Liposomal encapsulation of L-arginine and L-citrulline enhances pharmacokinetics and therapeutic effects in a model of preeclampsia and fetal growth restriction.

Scientific reports
2026

Racial Disparities in U.S. Peripartum Cardiomyopathy: Systematic Review and Meta-Analysis of Risk Factors and Outcomes.

JACC. Advances
2026

Uterotonics in pregnant patients with cardiac disease: a focused review.

International journal of obstetric anesthesia
2026

Combination of Markers, Including hsCRP, TGFβ 1, IL-6, and T-regs, and their Predictive Value as Early Warning Signs for Preeclampsia: Insights from a Tertiary Care Medical Centre in Eastern India.

Journal of mother and child
2026

Biomarkers of endothelial glycocalyx dysfunction in pregnancy: a systematic review of clinical relevance and detection techniques.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]
2026

[Once upon a time in nephrology - Episode 3: A brief history of preeclampsia].

Nephrologie &amp; therapeutique
2026

Hypertensive Disorders of Pregnancy and Primary Aldosteronism.

Hypertension (Dallas, Tex. : 1979)
2026

Maternal Morbidity and Complications in Hemolysis, Elevated Liver Enzymes, and Low Platelet Count (HELLP) Syndrome: A Retrospective Case Series.

Cureus
2026

The signature of pyroptosis-related gene diagnosis and immune microenvironment in preeclampsia.

BMC pregnancy and childbirth
2026

Persistent entropy links irregularities in daily and weekly rest and activity cycles during gestation week 22 and 32 to maternal and neonate health outcomes: A prospective cohort study.

PloS one
2026

Nicardipine Versus Nifedipine for Postpartum Hypertensive Emergencies in Severe Preeclampsia.

Journal of visualized experiments : JoVE
2026

Control of HELLP syndrome and pre-eclampsia with microbiota.

Molecular biology reports
2026

Pregnancy outcomes in juvenile idiopathic arthritis: systematic review and meta-analysis.

Proceedings (Baylor University. Medical Center)
2026

Severity-stratified genetic diagnosis by trio exome sequencing in isolated fetal growth restriction.

Frontiers in genetics
2026

Challenges and Prospects in Managing Hypertensive Disorders of Pregnancy in Sub-Saharan Africa: A Narrative Review.

International journal of women's health
2026

An interventional pilot study protocol on the effect of extra virgin olive oil on women with preeclampsia risk.

Annals of translational medicine
2026

Advanced maternal age and assisted reproductive technologies: outcomes, genomics, and real-world evidence.

Frontiers in reproductive health
2026

Stroke During Pregnancy and the Postpartum Period: A Nationwide Population-Based Study in South Korea.

International journal of stroke : official journal of the International Stroke Society
2026

The economic imperative of artificial intelligence in maternal and neonatal health: a review of evaluation benefits, frameworks, challenges, future perspectives, and limitations.

Cost effectiveness and resource allocation : C/E
2026

Stillbirths in women with hypertensive disorders in Pregnancy: Causes and investigations according to a multicenter study in Brazil.

Pregnancy hypertension
2026

Angiogenic Imbalance in Preeclampsia: Profiling VEGF A, sFlt1, PlGF, and sFlt1/PlGF Ratios.

International journal of molecular sciences
2026

Melatonin as a Redox Modulator in Developmental Programming: Implications for Cardiovascular-Kidney-Metabolic Risk.

International journal of molecular sciences
2026

Abnormal Galectin Signaling in the Pathomechanisms of Placental Dysfunction in Gestational Diabetes Mellitus.

International journal of molecular sciences
2026

Plasma RNA-Based Dual Screening for Early/Extreme Spontaneous Preterm Birth and Early Onset Preeclampsia to Enable Prevention.

Diagnostics (Basel, Switzerland)
2026

sFlt-1/PlGF Ratio as a Central Biomarker for Preeclampsia and Perinatal Outcomes: A Multisystem Retrospective Cohort Study.

Journal of clinical medicine
2026

Preeclampsia: Contemporary Concepts in Pathophysiology, Risk Stratification, Prevention and Monitoring.

Journal of clinical medicine
2026

Accelerated Vascular Aging in Women with Prior Preeclampsia: A Review of Epidemiology, Pathophysiological Mechanisms, and Geroprotective Strategies.

Journal of clinical medicine
2026

Alteration in Fetal Cardiac Function at Mid-Gestation Among Pregnancies Subsequently Complicated by Preeclampsia, Fetal Growth Restriction and Gestational Diabetes Mellitus: A Literature Review.

Journal of clinical medicine
2026

Ferroptosis-related gene BACH1 is associated with preeclampsia and shows potential as a biomarker.

BMC pregnancy and childbirth
2026

The burden of postpartum hypertension complications on urgent care utilization; a retrospective single centre study.

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC
2026

"MATERNAL CARDIOVASCULAR FUNCTION IN TWIN PREGNANCIES COMPLICATED BY PREECLAMPSIA: A MATCHED CROSS-SECTIONAL STUDY".

American journal of obstetrics &amp; gynecology MFM
2026

Disrupted placental circadian clock networks drive preeclampsia pathogenesis: An integrative bioinformatic analysis of key hub genes and regulatory pathways.

Placenta
2026

Efficacy of Low-dose Aspirin in Preventing Hypertensive Disorders of Pregnancy in Women with Systemic Lupus Erythematosus: A Single-Center Retrospective Cohort Study.

Modern rheumatology
2025

The Effect of Aspirin Administration on Fetal Cardiovascular Function Between 18 to 24 Weeks of Gestation: A New Perspective on ASA Indication in Obstetrics.

Journal of reproduction &amp; infertility
2026

The Role of Complement and CD4 T Cells in Preeclampsia and Offspring Neurodevelopment.

Current opinion in physiology
2026

Severe Preeclampsia and Oliguric Acute Tubular Necrosis Following Placental Abruption in a Dichorionic Diamniotic Twin Pregnancy.

Cureus
2026

Innovative mitochondria-based holistic 3PM approach to female health status: Facts and outlook.

The EPMA journal
2026

Systems-level actions of luteolin in female reproductive disorders: from molecular mechanisms to clinical translation.

Frontiers in pharmacology
2026

Placental weight may influence preeclampsia or eclampsia risk through modulating lipid metabolism: a mediation Mendelian randomization analysis.

The journal of maternal-fetal &amp; neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
2026

Acceptability and feasibility of the 4P care tele-nursing approach: perceptions of risk and needs of urban pregnancies at risk of preeclampsia.

Midwifery
2026

LncRNA SNHG1 promotes the development of preeclampsia by interacting with PTBP1 and modulating NGFR mRNA stability.

Life sciences
2026

Systematic review of cardiovascular intervention studies in women after Preeclampsia.

Pregnancy hypertension
2026

COVID-19 lockdown and association with placental function - a quasi-experimental analysis.

Pregnancy hypertension
2026

Immunoediting in pregnancy: a new paradigm for understanding fetal tolerance and obstetric disease.

Journal of perinatal medicine
2026

Nationwide Analysis of Maternal Mortality Due to Venous Thromboembolism.

Obstetrics and gynecology
2026

Beyond postdural puncture headache: headache and the puerperium.

Current opinion in anaesthesiology
2026

Machine Learning-Based Risk Prediction Models for Pregnancy-Related Syndromes.

Birth defects research
2026

Hypertensive disorders of pregnancy: A comprehensive review of pathophysiology, diagnosis, treatment, and long-term cardiovascular implications.

Clinical and experimental hypertension (New York, N.Y. : 1993)
2026

First-trimester β-hCG, PAPP-A, and NLR in relation to preeclampsia and perinatal outcomes: A case-control study.

Science progress
2026

Diagnosis and management of mirror syndrome: a case series with emphasis on the potential role of the sFLT-1/PlGF ratio in clinical practice.

Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia
2026

Coronary microvascular dysfunction in pregnancy: time to pay closer attention?

Frontiers in cardiovascular medicine
2026

A prospective multicenter register study exploring health-related quality of life in women with Sjögren's disease during pregnancy.

Frontiers in global women's health
2026

The association between breastfeeding and prevalence of metabolic syndrome in women with a previous major pregnancy complication.

Frontiers in global women's health
2026

HIF-1α mediated placental ischemic signaling in the development of early-onset preeclampsia.

Redox biology
2026

Maternal, Fetal, and Infant Outcomes Associated With Bariatric Surgery: A Matched Cohort Study.

Annals of surgery
2026

Silent Signals: The Expanding Role of Cell-Free DNA in Women's Health, Pregnancy, and Reproductive Medicine.

DNA and cell biology
2026

Remote blood pressure telemonitoring in hypertensive pregnancies: Feasibility and preliminary outcomes from a regional program.

Pregnancy hypertension
2026

Effect of COVID-19 infection on maternal and fetal outcomes of Pregnancy: A systematic review.

Pregnancy hypertension
2026

Spatiotemporal trends and regional inequities in preeclampsia and eclampsia in Brazil, 2008-2023.

Pregnancy hypertension
2026

Inhibition of NFAT after human uterus transplant promotes loss of tissue-resident NK cells and attendant pregnancy complications.

Science translational medicine
2026

Approaches to Identifying Neutrophil Extracellular Traps and Their Components in Preeclampsia.

Bulletin of experimental biology and medicine
2026

Unveiling preeclampsia: diagnostic value and potential molecular mechanisms of abnormally methylated immune-related genes.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
2026

Live Births Following IVF-FET in Two Adult Sisters with Nonclassic P450 Oxidoreductase Deficiency: A Case Report Identifying a Novel POR Variant.

International journal of women's health
2026

Associations Between Overt and Subclinical Hypothyroidism in Pregnancy and Adverse Maternal and Neonatal Outcomes: A cohort study.

Sultan Qaboos University medical journal
2026

Pravastatin Corrects Endothelial Dysfunction in Ex Vivo Uterine Radial Arteries in Preeclampsia.

Acta physiologica (Oxford, England)
2026

The dynamics of glycosylation in trophoblast cells: development, function, and pregnancy-related disorders.

Annals of medicine
2026

Preparation of placenta-tropic mRNA lipid nanoparticles for pregnancy disorders.

Nature protocols
2026

An early-onset preeclampsia study of C19MC: DNA methylation in the spermatozoa and, DNA methylation and expression in the placental villi.

Reproductive biology
2026

Postpartum readmission for hypertension: Impact of blood pressure stage at initial discharge.

Pregnancy hypertension
2026

Outcomes in pregnant women diagnosed with preeclampsia with and without fetal growth restriction at high altitude: A cross-sectional study.

Pregnancy hypertension
2026

Planned early-term delivery based on risk lowers pre-eclampsia incidence.

Nature cardiovascular research
2026

Magnesium sulfate pharmacology for maternal and critical-care indications: mechanisms, pharmacokinetics, and the therapeutic window.

Frontiers in pharmacology
2026

Heterozygous X-linked Alport syndrome in a pregnant woman: A case report.

SAGE open medical case reports
2026

Subtypes and onset of hypertensive disorders of pregnancy and cardiovascular disease within 5 years after delivery.

Frontiers in cardiovascular medicine
2026

Endogenous retroviral elements LTR8B and MER65 rewire PSG9 regulation to control trophoblast syncytialization and pre-eclampsia risk.

Genome biology
2026

Piezo1 modulates PFKFB3 during placental neovascularization in preeclampsia via YAP to regulate glycolysis in endothelial progenitor cells.

Placenta
2026

Two Successful Pregnancies in Women With Swyer Syndrome Using Oocyte Donation: Case Report.

The journal of obstetrics and gynaecology research
2026

Dialysis and Pregnancy: Optimizing Therapy for Best Maternal and Fetal Outcomes.

Hemodialysis international. International Symposium on Home Hemodialysis
2026

Functional characterization of the GWAS lead SNP rs888663 and effects of GDF15 SNPs on GDF15 levels in gestational hypertension and preeclampsia.

Molecular biology reports
2026

Phenotypic subclassification of preeclampsia through cluster analysis of preterm birth-related factors.

BMC medical informatics and decision making
2026

Pregnancy-related factors and risk of breast cancer in daughters: A systematic review and meta-analysis.

Maturitas
2026

Microbial dysbiosis and immunological dysregulation in pathological pregnancy.

Journal of reproductive immunology
2026

Machine Learning for Dynamic and Short-Term Prediction of Preeclampsia Using Routine Clinical Data.

JAMA network open
2026

Randomized Study of Antithrombin in Early-Onset Preeclampsia: KOUNO-TORI Study.

Hypertension (Dallas, Tex. : 1979)
2026

Epidemiology and Associated Factors of Superimposed Preeclampsia in Pregnant Women With Chronic Hypertension: A Retrospective Multicenter Cohort Study.

Journal of pregnancy
2026

Proteomic Epithelial-To-Mesenchymal Transition Signature in Fetoplacental Small Extracellular Vesicles of Early-Onset Preeclampsia.

Journal of extracellular biology
2026

Tailoring low-dose aspirin to prevent preeclampsia: translational and biomarker insights.

Frontiers in medicine
2026

PABPC1 regulates EOPE pathogenesis through modulating TMBIM4 mRNA expression and stability.

European journal of medical research
2026

Ultrasound-targeted delivery of miR-513a-5p inhibits ferroptosis and restores vascular function in preeclampsia.

Journal of molecular histology
2026

PM2.5 exposure induces functional alterations in pregnant rats heart and in human stem cell derived cardiac spheroids.

Archives of toxicology
2026

Metformin: An emerging therapeutic approach for prevention and treatment of preeclampsia.

European journal of obstetrics, gynecology, and reproductive biology
2026

Hematologic disorders in pregnancy: the role of the complement system.

Expert review of hematology
2026

Corrigendum for "Oxygen and TGF-β1 jointly regulate fibronectin and trophoblast behavior highlighting a potential role for matrix signaling in severe preeclampsia" [Matrix Biology 144 (2026) 13-25].

Matrix biology : journal of the International Society for Matrix Biology
2026

Bilateral Purtscher-like retinopathy in pre-eclampsia secondary to HELLP syndrome.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
2026

Ultraprocessed foods consumption and risk of preeclampsia: a secondary analysis of the improving mothers for a better prenatal care trial Barcelona (IMPACT BCN) randomized clinical trial.

The American journal of clinical nutrition
2026

Hypertensive Disorders of Pregnancy: A Systematic Review of International Clinical Practice Guidelines.

American journal of obstetrics and gynecology
2026

The Accuracy of the sFlt-1/PlGF Ratio Assay in Predicting Time to Delivery in Patients with Suspected Preeclampsia.

American journal of obstetrics and gynecology
2026

Statement of retraction: maternal serum inhibin-A for predicting preeclampsia.

The journal of maternal-fetal &amp; neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
2026

Perinatal use of targeted synthetic DMARDs and maternal-neonatal outcomes in autoimmune disease: A population-based cohort study.

Journal of autoimmunity
2026

Community awareness, perceptions, and management practices related to pre-eclampsia: An exploratory qualitative study in Mbale City, Eastern Uganda.

PloS one
2026

Maternal and Fetal Outcomes in Early-Onset vs. Late-Onset Preeclampsia: A Retrospective Study at a Tertiary Care Institute in India.

Cureus
2026

Severe Mitral Stenosis in Term Pregnancy Presenting During Labor in a Resource-Limited Setting: A Case Report from Borama, Awdal Region of Somalia.

International medical case reports journal
2026

Ginsenoside Rb1 alleviates endothelial dysfunction and vascular remodeling in preeclampsia via activation of the PI3K-Akt-eNOS pathway.

Scientific reports
2026

Research trends in pre-eclampsia and exosomes from 2009 to 2023: a bibliometric analysis.

Computers in biology and medicine
2026

Diagnostic and prognostic role of maternal serum prokineticin-1 in preeclampsia and adverse pregnancy outcomes.

Journal of the Turkish German Gynecological Association
2026

A study protocol for a predictive model to assess population‑based risk of adverse pregnancy outcomes: The Adverse Pregnancy Outcomes Population Risk Tool (PregPoRT).

Diagnostic and prognostic research
2026

Attention-deficit/hyperactivity disorder medication use and cardiometabolic conditions in pregnancy: a population-based cohort study.

Archives of women's mental health
2026

Melatonin in Preeclampsia: a Systematic Review of its Role in Pathogenesis and Therapeutic Potential.

Reproductive sciences (Thousand Oaks, Calif.)
2026

Expert consensus on pre-eclampsia risk screening tools for low- and middle-income countries: Development of a new Target Product Profile.

PLOS global public health
2026

Protocol for a process and implementation evaluation of the SMARThealth pregnancy hybrid type 2 cluster randomised controlled trial.

Women's health (London, England)
2025

Cardiovascular Disease and Pregnancy: Clinical Outcomes From a Tertiary Center Experience in Saudi Arabia.

Journal of the Saudi Heart Association
2026

Investigation of Netrin-1 Levels in Maternal and Umbilical Cord Serum in Preeclampsia and Their Relationship With Vitamin D, Vitamin B12, and Folic Acid.

Cureus
2026

Effectiveness of Prenatal Counselling on Physical and Psychological Well-Being Among Women With Preeclampsia at a Tertiary Care Hospital in India.

Cureus
2026

Maternal Cardiac Arrest During Cesarean Section in the Setting of Severe Preeclampsia and Uncontrolled Type 1 Diabetes: A Case Report.

Cureus
2025

Double Jeopardy: The Intersection of COVID-19 and Pregnancy in an Educational Hospital, Northern Iran, Gorgan.

Archives of Razi Institute
2026

The virtual indigenous data science academy: development of a summer program in data science for tribal college students.

Frontiers in public health
2026

Evaluation of extravascular lung water and cardiac function by intrapartum bedside ultrasound: full-term preeclampsia vs. healthy controls.

Frontiers in cardiovascular medicine
2025

Incidence of pre-eclampsia and its associated factors among pregnant women attending antenatal clinic at the 37 Military Hospital in Ghana.

BMJ nutrition, prevention &amp; health
2025

Building a foundation to promote Women's health research in Dubai. Study protocol for a project to investigate the feasibility of establishing a dedicated Women's health biobank.

Frontiers in global women's health
2026

The clinical value of nomogram combined with machine learning models in predicting the progression of hypertensive disorders in pregnancy to severe preeclampsia.

Frontiers in global women's health
2026

Development of a Triage Tool for Stratification and Referral of Women at Risk of Preeclampsia in Low-Resource Antenatal Settings: A Prospective Cohort Study.

Health science reports
2026

Post-traumatic stress disorder and adverse pregnancy outcomes: sexual orientation disparities in a prospective cohort study.

BMC pregnancy and childbirth
2026

[Analysis of maternal and fetal outcomes and related factors of recurrence in women with a history of pre-eclampsia].

Zhonghua fu chan ke za zhi
2026

ZFP36 inhibits trophoblast ferroptosis and attenuates preeclampsia development by promoting NCOA4 mRNA degradation and suppressing ferritinophagy.

Biochemical pharmacology
2026

Reduced syncytiotrophoblast-glycocalyx expression is associated with placental malperfusion and the severity of late-onset preeclampsia.

Pregnancy hypertension
2026

Faecalibacterium prausnitzii: A microbial ally against preeclampsia via extracellular vesicle-mediated ferroptosis inhibition.

Free radical biology &amp; medicine
2026

STAT signaling pathway in pregnancy stages and related to complications.

Cellular immunology
2026

Analysis of stillbirth: a retrospective study in China.

Journal of perinatal medicine
2026

The Predictive Value of P-Wave Dispersion and QTc Dispersion in Preeclampsia.

Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc
2026

Construction and comparison of preeclampsia prediction models using logistic regression and machine learning.

BMC medical informatics and decision making
2026

Effect of first-trimester aspirin initiation timing on obstetric outcomes: A comparative study.

Medicine
2026

In Vitro Fertilization and Placenta Accreta (spectrum): A Systematic Review.

JBRA assisted reproduction
2026

Brazilian green propolis exerts anti-inflammatory effects on monocytes from women with early- and late-onset preeclampsia.

The Journal of pharmacy and pharmacology
2026

Adverse Pregnancy Outcomes and Long-Term Risk of Chronic Diseases: Evidence from the Findings of the Tehran Lipid and Glucose Study During a Quarter of a Century.

International journal of endocrinology and metabolism
2026

Clinical Characteristics and Maternal-Perinatal Outcomes of In Vitro Fertilization Patients Referred to a Hospital in Lima, Peru.

Cureus
2026

The Association Between Periconceptional Consumption of Ultra-Processed Food and the Incidence of Adverse Pregnancy Outcomes.

Nutrients
2026

Maternal and Neonatal Outcomes in Very Young Adolescent Pregnancies: A Single-Centre Retrospective Observational Study in Brașov, Romania.

Healthcare (Basel, Switzerland)
2026

Altered PAPP-A and Placental Thickness in Pre-Eclampsia and Intrauterine Growth Restriction: A Pilot Study.

Journal of clinical medicine
2026

Peripartum Depression as a Heart-Brain-Endocrine-Immune Syndrome: Neuroendocrine, Cardiovascular, and Inflammatory Pathways Underlying Maternal Vulnerability.

Life (Basel, Switzerland)
2026

Pre-Eclampsia-Induced Maternal Liver Dysfunction: Systematic Review, Meta-Analysis and Meta-Regression of Observation Studies.

Life (Basel, Switzerland)
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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Research progress on histone epigenetic modifications in placental trophoblast syncytialization.
    Life sciences· 2026· PMID 41871662mais citado
  2. Leveraging PANoptosis-associated genes for unraveling implication of decidualization deficiency in pre-eclampsia via transcriptome data and experiment validation.
    Frontiers in cell and developmental biology· 2026· PMID 41858783mais citado
  3. Long-term cardiac consequences of fetal exposure to preeclampsia: a speckle tracking echocardiography analysis.
    European journal of pediatrics· 2026· PMID 41857424mais citado
  4. Hypertension action bundle including training of healthcare professionals to improve the detection of primary aldosteronism: a cohort study.
    Blood pressure· 2026· PMID 41852294mais citado
  5. Persistent entropy links irregularities in daily and weekly rest and activity cycles during gestation week 22 and 32 to maternal and neonate health outcomes: A prospective cohort study.
    PloS one· 2026· PMID 41838777mais citado
  6. Bedside Multimodal Ultrasonography for the Detection of Intracranial Hypertension in Severe Adolescent Preeclampsia: A Case Report and Screening Proposal.
    Cureus· 2026· PMID 41994841recente
  7. Cell-free mitochondrial DNA and microRNA-137 for early diagnosis of preeclampsia.
    Front Cardiovasc Med· 2026· PMID 41993856recente
  8. From Maternal Exposure to Fetal Risk: Unraveling the PFAS Exposure Pathway and Its Placental Toxicity Mechanism.
    Environ Sci Technol· 2026· PMID 41992854recente
  9. The effect of yoga on birth outcomes of Chinese pregnancies with preeclampsia.
    BMC Pregnancy Childbirth· 2026· PMID 41992170recente
  10. Revealing an enhanced cytotoxic immune microenvironment at the human maternal-fetal interface in preeclampsia.
    Cell Biol Toxicol· 2026· PMID 41991681recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:275555(Orphanet)
  2. MONDO:0005081(MONDO)
  3. GARD:12924(GARD (NIH))
  4. Variantes catalogadas(ClinVar)
  5. Busca completa no PubMed(PubMed)
  6. Artigo Wikipedia(Wikipedia)
  7. Q61335(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Pré-eclâmpsia
Compêndio · Raras BR

Pré-eclâmpsia

ORPHA:275555 · MONDO:0005081
Prevalência
1-5 / 10 000
Herança
Not applicable
CID-10
O14.2 · Hipertensão gestacional [induzida pela gravidez] com proteinúria significativa
CID-11
Ensaios
22 ativos
Início
Adult
Prevalência
45.0 (Europe)
MedGen
UMLS
C0032914
Wikidata
Wikipedia
Papers 10a
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