A pré-eclâmpsia é um distúrbio hipertensivo da gravidez caracterizado por hipertensão de início recente com proteinúria que se manifesta após 20 semanas de gestação e, dependendo das formas leves ou graves, pode inicialmente apresentar cefaleia intensa, distúrbios visuais e hiperreflexia.
Introdução
O que você precisa saber de cara
A pré-eclâmpsia é um distúrbio hipertensivo da gravidez caracterizado por hipertensão de início recente com proteinúria que se manifesta após 20 semanas de gestação e, dependendo das formas leves ou graves, pode inicialmente apresentar cefaleia intensa, distúrbios visuais e hiperreflexia.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 24 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 50 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
7 genes identificados com associação a esta condição. Padrão de herança: Not applicable.
Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) and brain natriuretic peptide (NPPB) processing (PubMed:10880574, PubMed:20489134, PubMed:21288900, PubMed:21763278). Converts through proteolytic cleavage the non-functional propeptides NPPA and NPPB into their active hormones, ANP and BNP(1-32) respectively, thereby regulating blood pressure in the heart and promoting natriuresis, diuresis and vasodilation (PubMed:10880574, PubMed:20489134, PubMed:21288900, PubMed:21763278
Cell membraneSecreted
Pre-eclampsia/eclampsia 5
A hypertensive disorder of pregnancy characterized by new hypertension (blood pressure 140/90 or greater) presenting after 20 weeks' gestation with clinically relevant proteinuria. It impacts 2 individuals, the mother and her child, both of whom can be severely affected. Preeclampsia is one of the causes of maternal mortality and morbidity worldwide.
Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three peptide bonds in the alpha-chain of C3b and two bonds in the alpha-chain of C4b thereby inactivating these proteins (PubMed:17320177, PubMed:7360115). Essential cofactors for these reactions include factor H and C4BP in the fluid phase and membrane cofactor protein/CD46 and CR1 on cell surfaces (PubMed:12055245, PubMed:21418
Secreted, extracellular spaceSecreted
Hemolytic uremic syndrome, atypical, 3
An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease.
Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces (PubMed:21285368, PubMed:21317894, PubMed:25402769). Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of
Secreted
Basal laminar drusen
Drusen are extracellular deposits that accumulate below the retinal pigment epithelium on Bruch membrane. Basal laminar drusen refers to an early adult-onset drusen phenotype that shows a pattern of uniform small, slightly raised yellow subretinal nodules randomly scattered in the macula. In later stages, these drusen often become more numerous, with clustered groups of drusen scattered throughout the retina. In time these small basal laminar drusen may expand and ultimately lead to a serous pigment epithelial detachment of the macula that may result in vision loss.
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent auto
Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane
Hemolytic uremic syndrome, atypical, 2
An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease.
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (By similarity). May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothe
Cell membraneEndosomeSecretedCytoplasm
Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta (PubMed:24738702). Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway (By similarity) Involved in cell cycle regulation by binding to the CCNB1 promoter, up-regulating its expression and promoting mitotic entry (PubMed:22253775). Induces phosphorylation of MAPT/tau (PubMed:22995177)
CytoplasmNucleusCytoplasm, cytoskeleton, microtubule organizing center, centrosomeNucleus, nucleolus
Pre-eclampsia/eclampsia 4
A hypertensive disorder of pregnancy characterized by new hypertension (blood pressure 140/90 or greater) presenting after 20 weeks' gestation with clinically relevant proteinuria. It impacts 2 individuals, the mother and her child, both of whom can be severely affected. Preeclampsia is one of the causes of maternal mortality and morbidity worldwide.
Medicamentos aprovados (FDA)
3 medicamentos encontrados nos registros da FDA americana.
Variantes genéticas (ClinVar)
242 variantes patogênicas registradas no ClinVar.
Classificação de variantes (ClinVar)
Distribuição de 68 variantes classificadas pelo ClinVar.
Vias biológicas (Reactome)
4 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Pré-eclâmpsia
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932 ensaios clínicos encontrados, 22 ativos.
Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 25.900
Research progress on histone epigenetic modifications in placental trophoblast syncytialization.
Este artigo destaca que a pré-eclâmpsia e outras doenças da gravidez estão associadas a falhas na formação da placenta, especialmente na fusão de suas células (sincicialização). Este processo crucial é finamente regulado por modificações epigenéticas, e a disfunção nessas regulagens é um fator chave no surgimento das complicações. Compreender essas alterações oferece grande potencial para o desenvolvimento de novos métodos de diagnóstico precoce e terapias mais eficazes, beneficiando diretamente pacientes e médicos no manejo da pré-eclâmpsia.
🇧🇷 traduzidoLeveraging PANoptosis-associated genes for unraveling implication of decidualization deficiency in pre-eclampsia via transcriptome data and experiment validation.
Este estudo revela que a pré-eclâmpsia está associada à deficiência de decidualização e a uma forma de morte celular inflamatória chamada PANoptosis. Foram identificados genes específicos relacionados à PANoptosis que podem servir como biomarcadores para o diagnóstico precoce da doença. Além disso, a melatonina emergiu como um candidato terapêutico promissor, demonstrando efeitos protetores como melhora da pressão arterial e restauração parcial da decidualização, ao modular essas vias.
🇧🇷 traduzidoLong-term cardiac consequences of fetal exposure to preeclampsia: a speckle tracking echocardiography analysis.
Este estudo mostra que crianças expostas à pré-eclâmpsia no útero apresentam alterações sutis na função cardíaca (sistólica e diastólica), que não são identificadas em exames de ecocardiograma convencionais. Essas disfunções sublícnicas são detectadas apenas por métodos avançados, como a ecocardiografia com *speckle tracking* 2D. Assim, para médicos e pacientes, é crucial o monitoramento cardíaco a longo prazo com essa técnica especializada para essa população de risco, a fim de identificar e acompanhar precocemente potenciais problemas cardiovasculares, independentemente do tipo de pré-eclâmpsia.
🇧🇷 traduzidoHypertension action bundle including training of healthcare professionals to improve the detection of primary aldosteronism: a cohort study.
Este estudo demonstrou que um programa de treinamento para profissionais de saúde, incluindo clínicos gerais, cardiologistas e ginecologistas, aumentou significativamente (em cerca de quatro vezes) a detecção do hiperaldosteronismo primário (HAP), uma causa tratável e frequentemente subdiagnosticada de hipertensão. A melhora na identificação do HAP ocorreu porque os médicos passaram a rastrear a doença em perfis menos comuns, como pacientes jovens, com hipertensão refratária ou com histórico de pré-eclâmpsia. Essa abordagem multidisciplinar é crucial para que mais pacientes com HAP recebam o diagnóstico e o tratamento específico, essencial para controlar a pressão arterial e reduzir os riscos cardiovasculares.
🇧🇷 traduzidoPersistent entropy links irregularities in daily and weekly rest and activity cycles during gestation week 22 and 32 to maternal and neonate health outcomes: A prospective cohort study.
Um estudo recente sugere que padrões diários de repouso e atividade muito irregulares, medidos por uma nova técnica chamada "entropia persistente" durante a gravidez (semanas 22 e 32), estão associados a um risco significativamente maior de complicações maternas e neonatais, incluindo pré-eclâmpsia. Tais irregularidades, especialmente na semana 22 e mais acentuadamente em gestantes com IMC elevado, podem ter valor preditivo, indicando que monitorar a consistência do ciclo de repouso-atividade pode ser uma ferramenta útil para identificar riscos. Contudo, são necessários estudos maiores para confirmar esses achados e avaliar seu uso clínico como ferramenta de rastreamento.
🇧🇷 traduzidoPublicações recentes
Bedside Multimodal Ultrasonography for the Detection of Intracranial Hypertension in Severe Adolescent Preeclampsia: A Case Report and Screening Proposal.
Cell-free mitochondrial DNA and microRNA-137 for early diagnosis of preeclampsia.
📖 RevisãoFrom Maternal Exposure to Fetal Risk: Unraveling the PFAS Exposure Pathway and Its Placental Toxicity Mechanism.
The effect of yoga on birth outcomes of Chinese pregnancies with preeclampsia.
Revealing an enhanced cytotoxic immune microenvironment at the human maternal-fetal interface in preeclampsia.
📚 EuropePMC16.307 artigos no totalmostrando 195
Bariatric Surgery, Gestational Diabetes and Perinatal Outcomes: A Population-Based Study.
BJOG : an international journal of obstetrics and gynaecologyIsolated hypoglossal nerve mononeuropathy associated with preeclampsia in late pregnancy: a case report.
Journal of medical case reportsEffects of Nutritional Supplement Intake on Pregnancy Outcomes in Overweight and Obese Women: A Systematic Review and Meta-Analysis.
The journal of obstetrics and gynaecology research"Letter to Editor regarding 'Maternal, fetal, and neonatal serious adverse events associated with lowdose aspirin during the first trimester of pregnancy: A secondary analysis of the Aspirin Supplmentation for Pregnancy Indicated Risk Reduction In Nulliparas (ASPIRIN) trial"'.
American journal of obstetrics & gynecology MFMResearch progress on histone epigenetic modifications in placental trophoblast syncytialization.
Life sciencesDisrupting the circTNC/miR-582-5p/MAPK8 axis alleviates oxidative stress-induced trophoblast dysfunction in preeclampsia.
Journal of molecular histologyThe expression and mechanism of action of MicroRNA-210 in preeclampsia.
Clinical and investigative medicine. Medecine clinique et experimentaleHydroxychloroquine-Use and Preeclampsia and Preterm Delivery Complications in Systemic Lupus Erythematosus Pregnancies: Is there a protective effect?
Arthritis care & researchIncidence and Predictors of Preeclampsia Among Pregnant Women With Urinary Tract Infection: A Prospective Observational Study.
CureusThreshold-dependent effect of the neutrophil-to-albumin ratio (NAR) in early pregnancy: a novel insight for preeclampsia risk prediction.
American journal of translational researchPericonceptional Folic Acid Supplementation and the Risk of Preeclampsia in Eastern Sudan: An Unmatched Case-Control Study.
International journal of women's healthEast Asian Mendelian-Randomization Evidence Linking PCOS to Gestational Diabetes Mellitus.
International journal of women's healthKnowledge of Pre-Eclampsia and Its Risk Factors Among Pregnant Women Attending Antenatal Care in Lango Sub-Region, Northern Uganda.
International journal of women's healthNutritional Management in Pregnant Women with Preeclampsia: A Scoping Review.
Journal of multidisciplinary healthcare2D Shear Wave Elastography: An Evolving Technique for Comparison of Placental Elasticity in Normal and Preeclamptic Pregnancy.
The Indian journal of radiology & imagingEvaluation of Maternal Ophthalmic Artery Doppler Velocimetry at 18 to 24 Weeks of Gestational Age in the Prediction of Preeclampsia.
The Indian journal of radiology & imagingHistone Acetyltransferase KAT14 Mediates CDH5 to Regulate Spiral Artery Remodeling in Preeclampsia via Cooperation With SRF.
Hypertension (Dallas, Tex. : 1979)Targeted delivery of RGD-JEG-3-EVs for placental vascular regeneration in preeclampsia: from molecular mechanism toward therapy.
Apoptosis : an international journal on programmed cell deathMaternal hypertension and survival without bronchopulmonary dysplasia in preterm infants: a meta-analysis of cohort studies.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal ObstetriciansRe-evaluating the clinical interpretation of sFlt-1/PlGF in diabetes-complicated preeclampsia.
Pregnancy hypertensionThe relationship between APOL1 risk variants and with preeclampsia and fetal outcomes.
Pregnancy hypertensionCalcineurin inhibitors and the risk of preeclampsia in solid organ transplantation - Should we rethink our approach during pregnancy?
Pregnancy hypertensionConstruction of a diagnostic model for preeclampsia based on differentially expressed lactylation-related genes and the immune infiltration analysis.
Scientific reportsFirst-trimester serum placental growth factor and risk of severe maternal morbidity and mortality.
American journal of obstetrics and gynecologyParameters of the thrombin generation test in pregnant women with preeclampsia: a systematic review.
BMC pregnancy and childbirthEmerging ultrasound-based imaging of the placenta during complications of pregnancy.
PlacentaDECR1 deficiency activates a lipid peroxidation-mitocytosis-mitochondrial dysfunction axis in trophoblasts to promote preeclampsia.
Free radical biology & medicineGestational diabetes mellitus in low- and middle-income countries: a systematic review and meta-analysis of associated factors.
Diabetes research and clinical practicemicroRNA-155: a versatile noncoding RNA.
Molecular biology reportsLifetime Adverse Pregnancy Outcome History and Cardiovascular Risk.
Hypertension (Dallas, Tex. : 1979)Effects of Antihypertensive Therapy on Pre- and Postnatal Maternal Hemodynamics.
Hypertension (Dallas, Tex. : 1979)A Comparative Cross-Sectional Study Between Gestational Diabetes Mellitus and Preeclampsia: Medication Adherence, Depression and Quality of Life.
International journal of women's healthBeyond HELLP: An Unusual Cause of Severe Thrombocytopenia in Pregnancy.
CureusCurrent Understanding on Hypertensive Disorders in Pregnancy.
International journal of general medicineProfound hyponatraemia in early-onset preeclampsia: a case report of a rare and complex presentation.
Case reports in women's healthLeveraging PANoptosis-associated genes for unraveling implication of decidualization deficiency in pre-eclampsia via transcriptome data and experiment validation.
Frontiers in cell and developmental biologyNano-Enabled Therapeutics: Novel Strategies for Preeclampsia Treatment.
International journal of nanomedicine-Impact of first-trimester preeclampsia screening on perinatal and maternal morbidity: the RANSPRE open multicenter randomized trial.
BMC pregnancy and childbirthComprehensive analysis of RNA sequencing reveals DNA damage response and immune-associated alternative splicing and RBP regulators contributing to preeclampsia.
BMC genomicsLong-term cardiac consequences of fetal exposure to preeclampsia: a speckle tracking echocardiography analysis.
European journal of pediatricsLow-Dose Aspirin Recommendations for Preeclampsia Risk Reduction: A Systematic Review Focused on Black Patients : Current Hypertension Reports.
Current hypertension reportsLeveraging the All of Us Research Program to Advance Women's Health: Addressing Conditions that Affect Women Differently, Disproportionately, and Uniquely.
Journal of women's health (2002)Comparison of 162 mg and 81 mg Aspirin for Prevention of Preeclampsia: A Randomized Controlled Trial.
Obstetrics and gynecologyIntegrative biology shows DPP4 affects inflammatory response to eclampsia and cell model growth via p65/NLRP3/ASC/Caspase-1 pathway.
Frontiers in geneticsHypertension action bundle including training of healthcare professionals to improve the detection of primary aldosteronism: a cohort study.
Blood pressureHalogenated phenolic disinfectants suppress 11β-hydroxysteroid dehydrogenase 2 activity in human and rat models: Experimental and computational evidence.
The Journal of steroid biochemistry and molecular biologyThe influence of labor and gestational age on maternal IL-6 and IL-10 plasma levels in preeclampsia.
Journal of reproductive immunologyDetermining the desired concentration of a nutraceutical based on the variation of its concentration with the incidence of a disease: application to ergothioneine and pre-eclampsia.
Pregnancy hypertensionEffect of Paracetamol on Blood Pressure: A Systematic Review.
La Tunisie medicalePlacental Autophagy: Causes and Consequences.
Current opinion in physiologyEffects of early vs. late administration of labetalol on maternal cerebral perfusion and fetal growth in severe pre-eclampsia.
Frontiers in medicineTransplantation and Mortality in Women After Delivering on Hemodialysis.
Kidney international reportsAngiogenic imbalance and endothelial dysfunction in the placenta in antiphospholipid syndrome.
Autoimmunity reviewsCalcium supplementation for prevention of pre-eclampsia in high-risk women: study protocol for a randomised triple-blind placebo-controlled trial (CaPE).
TrialsThe impact of pre-pregnancy body mass index and maternal diseases on the offspring outcomes in preterm infants < 32 weeks: five-year retrospective mediation analysis.
BMC pregnancy and childbirthLiposomal encapsulation of L-arginine and L-citrulline enhances pharmacokinetics and therapeutic effects in a model of preeclampsia and fetal growth restriction.
Scientific reportsRacial Disparities in U.S. Peripartum Cardiomyopathy: Systematic Review and Meta-Analysis of Risk Factors and Outcomes.
JACC. AdvancesUterotonics in pregnant patients with cardiac disease: a focused review.
International journal of obstetric anesthesiaCombination of Markers, Including hsCRP, TGFβ 1, IL-6, and T-regs, and their Predictive Value as Early Warning Signs for Preeclampsia: Insights from a Tertiary Care Medical Centre in Eastern India.
Journal of mother and childBiomarkers of endothelial glycocalyx dysfunction in pregnancy: a systematic review of clinical relevance and detection techniques.
Inflammation research : official journal of the European Histamine Research Society ... [et al.][Once upon a time in nephrology - Episode 3: A brief history of preeclampsia].
Nephrologie & therapeutiqueHypertensive Disorders of Pregnancy and Primary Aldosteronism.
Hypertension (Dallas, Tex. : 1979)Maternal Morbidity and Complications in Hemolysis, Elevated Liver Enzymes, and Low Platelet Count (HELLP) Syndrome: A Retrospective Case Series.
CureusThe signature of pyroptosis-related gene diagnosis and immune microenvironment in preeclampsia.
BMC pregnancy and childbirthPersistent entropy links irregularities in daily and weekly rest and activity cycles during gestation week 22 and 32 to maternal and neonate health outcomes: A prospective cohort study.
PloS oneNicardipine Versus Nifedipine for Postpartum Hypertensive Emergencies in Severe Preeclampsia.
Journal of visualized experiments : JoVEControl of HELLP syndrome and pre-eclampsia with microbiota.
Molecular biology reportsPregnancy outcomes in juvenile idiopathic arthritis: systematic review and meta-analysis.
Proceedings (Baylor University. Medical Center)Severity-stratified genetic diagnosis by trio exome sequencing in isolated fetal growth restriction.
Frontiers in geneticsChallenges and Prospects in Managing Hypertensive Disorders of Pregnancy in Sub-Saharan Africa: A Narrative Review.
International journal of women's healthAn interventional pilot study protocol on the effect of extra virgin olive oil on women with preeclampsia risk.
Annals of translational medicineAdvanced maternal age and assisted reproductive technologies: outcomes, genomics, and real-world evidence.
Frontiers in reproductive healthStroke During Pregnancy and the Postpartum Period: A Nationwide Population-Based Study in South Korea.
International journal of stroke : official journal of the International Stroke SocietyThe economic imperative of artificial intelligence in maternal and neonatal health: a review of evaluation benefits, frameworks, challenges, future perspectives, and limitations.
Cost effectiveness and resource allocation : C/EStillbirths in women with hypertensive disorders in Pregnancy: Causes and investigations according to a multicenter study in Brazil.
Pregnancy hypertensionAngiogenic Imbalance in Preeclampsia: Profiling VEGF A, sFlt1, PlGF, and sFlt1/PlGF Ratios.
International journal of molecular sciencesMelatonin as a Redox Modulator in Developmental Programming: Implications for Cardiovascular-Kidney-Metabolic Risk.
International journal of molecular sciencesAbnormal Galectin Signaling in the Pathomechanisms of Placental Dysfunction in Gestational Diabetes Mellitus.
International journal of molecular sciencesPlasma RNA-Based Dual Screening for Early/Extreme Spontaneous Preterm Birth and Early Onset Preeclampsia to Enable Prevention.
Diagnostics (Basel, Switzerland)sFlt-1/PlGF Ratio as a Central Biomarker for Preeclampsia and Perinatal Outcomes: A Multisystem Retrospective Cohort Study.
Journal of clinical medicinePreeclampsia: Contemporary Concepts in Pathophysiology, Risk Stratification, Prevention and Monitoring.
Journal of clinical medicineAccelerated Vascular Aging in Women with Prior Preeclampsia: A Review of Epidemiology, Pathophysiological Mechanisms, and Geroprotective Strategies.
Journal of clinical medicineAlteration in Fetal Cardiac Function at Mid-Gestation Among Pregnancies Subsequently Complicated by Preeclampsia, Fetal Growth Restriction and Gestational Diabetes Mellitus: A Literature Review.
Journal of clinical medicineFerroptosis-related gene BACH1 is associated with preeclampsia and shows potential as a biomarker.
BMC pregnancy and childbirthThe burden of postpartum hypertension complications on urgent care utilization; a retrospective single centre study.
Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC"MATERNAL CARDIOVASCULAR FUNCTION IN TWIN PREGNANCIES COMPLICATED BY PREECLAMPSIA: A MATCHED CROSS-SECTIONAL STUDY".
American journal of obstetrics & gynecology MFMDisrupted placental circadian clock networks drive preeclampsia pathogenesis: An integrative bioinformatic analysis of key hub genes and regulatory pathways.
PlacentaEfficacy of Low-dose Aspirin in Preventing Hypertensive Disorders of Pregnancy in Women with Systemic Lupus Erythematosus: A Single-Center Retrospective Cohort Study.
Modern rheumatologyThe Effect of Aspirin Administration on Fetal Cardiovascular Function Between 18 to 24 Weeks of Gestation: A New Perspective on ASA Indication in Obstetrics.
Journal of reproduction & infertilityThe Role of Complement and CD4 T Cells in Preeclampsia and Offspring Neurodevelopment.
Current opinion in physiologySevere Preeclampsia and Oliguric Acute Tubular Necrosis Following Placental Abruption in a Dichorionic Diamniotic Twin Pregnancy.
CureusInnovative mitochondria-based holistic 3PM approach to female health status: Facts and outlook.
The EPMA journalSystems-level actions of luteolin in female reproductive disorders: from molecular mechanisms to clinical translation.
Frontiers in pharmacologyPlacental weight may influence preeclampsia or eclampsia risk through modulating lipid metabolism: a mediation Mendelian randomization analysis.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal ObstetriciansAcceptability and feasibility of the 4P care tele-nursing approach: perceptions of risk and needs of urban pregnancies at risk of preeclampsia.
MidwiferyLncRNA SNHG1 promotes the development of preeclampsia by interacting with PTBP1 and modulating NGFR mRNA stability.
Life sciencesSystematic review of cardiovascular intervention studies in women after Preeclampsia.
Pregnancy hypertensionCOVID-19 lockdown and association with placental function - a quasi-experimental analysis.
Pregnancy hypertensionImmunoediting in pregnancy: a new paradigm for understanding fetal tolerance and obstetric disease.
Journal of perinatal medicineNationwide Analysis of Maternal Mortality Due to Venous Thromboembolism.
Obstetrics and gynecologyBeyond postdural puncture headache: headache and the puerperium.
Current opinion in anaesthesiologyMachine Learning-Based Risk Prediction Models for Pregnancy-Related Syndromes.
Birth defects researchHypertensive disorders of pregnancy: A comprehensive review of pathophysiology, diagnosis, treatment, and long-term cardiovascular implications.
Clinical and experimental hypertension (New York, N.Y. : 1993)First-trimester β-hCG, PAPP-A, and NLR in relation to preeclampsia and perinatal outcomes: A case-control study.
Science progressDiagnosis and management of mirror syndrome: a case series with emphasis on the potential role of the sFLT-1/PlGF ratio in clinical practice.
Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e ObstetriciaCoronary microvascular dysfunction in pregnancy: time to pay closer attention?
Frontiers in cardiovascular medicineA prospective multicenter register study exploring health-related quality of life in women with Sjögren's disease during pregnancy.
Frontiers in global women's healthThe association between breastfeeding and prevalence of metabolic syndrome in women with a previous major pregnancy complication.
Frontiers in global women's healthHIF-1α mediated placental ischemic signaling in the development of early-onset preeclampsia.
Redox biologyMaternal, Fetal, and Infant Outcomes Associated With Bariatric Surgery: A Matched Cohort Study.
Annals of surgerySilent Signals: The Expanding Role of Cell-Free DNA in Women's Health, Pregnancy, and Reproductive Medicine.
DNA and cell biologyRemote blood pressure telemonitoring in hypertensive pregnancies: Feasibility and preliminary outcomes from a regional program.
Pregnancy hypertensionEffect of COVID-19 infection on maternal and fetal outcomes of Pregnancy: A systematic review.
Pregnancy hypertensionSpatiotemporal trends and regional inequities in preeclampsia and eclampsia in Brazil, 2008-2023.
Pregnancy hypertensionInhibition of NFAT after human uterus transplant promotes loss of tissue-resident NK cells and attendant pregnancy complications.
Science translational medicineApproaches to Identifying Neutrophil Extracellular Traps and Their Components in Preeclampsia.
Bulletin of experimental biology and medicineUnveiling preeclampsia: diagnostic value and potential molecular mechanisms of abnormally methylated immune-related genes.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicasLive Births Following IVF-FET in Two Adult Sisters with Nonclassic P450 Oxidoreductase Deficiency: A Case Report Identifying a Novel POR Variant.
International journal of women's healthAssociations Between Overt and Subclinical Hypothyroidism in Pregnancy and Adverse Maternal and Neonatal Outcomes: A cohort study.
Sultan Qaboos University medical journalPravastatin Corrects Endothelial Dysfunction in Ex Vivo Uterine Radial Arteries in Preeclampsia.
Acta physiologica (Oxford, England)The dynamics of glycosylation in trophoblast cells: development, function, and pregnancy-related disorders.
Annals of medicinePreparation of placenta-tropic mRNA lipid nanoparticles for pregnancy disorders.
Nature protocolsAn early-onset preeclampsia study of C19MC: DNA methylation in the spermatozoa and, DNA methylation and expression in the placental villi.
Reproductive biologyPostpartum readmission for hypertension: Impact of blood pressure stage at initial discharge.
Pregnancy hypertensionOutcomes in pregnant women diagnosed with preeclampsia with and without fetal growth restriction at high altitude: A cross-sectional study.
Pregnancy hypertensionPlanned early-term delivery based on risk lowers pre-eclampsia incidence.
Nature cardiovascular researchMagnesium sulfate pharmacology for maternal and critical-care indications: mechanisms, pharmacokinetics, and the therapeutic window.
Frontiers in pharmacologyHeterozygous X-linked Alport syndrome in a pregnant woman: A case report.
SAGE open medical case reportsSubtypes and onset of hypertensive disorders of pregnancy and cardiovascular disease within 5 years after delivery.
Frontiers in cardiovascular medicineEndogenous retroviral elements LTR8B and MER65 rewire PSG9 regulation to control trophoblast syncytialization and pre-eclampsia risk.
Genome biologyPiezo1 modulates PFKFB3 during placental neovascularization in preeclampsia via YAP to regulate glycolysis in endothelial progenitor cells.
PlacentaTwo Successful Pregnancies in Women With Swyer Syndrome Using Oocyte Donation: Case Report.
The journal of obstetrics and gynaecology researchDialysis and Pregnancy: Optimizing Therapy for Best Maternal and Fetal Outcomes.
Hemodialysis international. International Symposium on Home HemodialysisFunctional characterization of the GWAS lead SNP rs888663 and effects of GDF15 SNPs on GDF15 levels in gestational hypertension and preeclampsia.
Molecular biology reportsPhenotypic subclassification of preeclampsia through cluster analysis of preterm birth-related factors.
BMC medical informatics and decision makingPregnancy-related factors and risk of breast cancer in daughters: A systematic review and meta-analysis.
MaturitasMicrobial dysbiosis and immunological dysregulation in pathological pregnancy.
Journal of reproductive immunologyMachine Learning for Dynamic and Short-Term Prediction of Preeclampsia Using Routine Clinical Data.
JAMA network openRandomized Study of Antithrombin in Early-Onset Preeclampsia: KOUNO-TORI Study.
Hypertension (Dallas, Tex. : 1979)Epidemiology and Associated Factors of Superimposed Preeclampsia in Pregnant Women With Chronic Hypertension: A Retrospective Multicenter Cohort Study.
Journal of pregnancyProteomic Epithelial-To-Mesenchymal Transition Signature in Fetoplacental Small Extracellular Vesicles of Early-Onset Preeclampsia.
Journal of extracellular biologyTailoring low-dose aspirin to prevent preeclampsia: translational and biomarker insights.
Frontiers in medicinePABPC1 regulates EOPE pathogenesis through modulating TMBIM4 mRNA expression and stability.
European journal of medical researchUltrasound-targeted delivery of miR-513a-5p inhibits ferroptosis and restores vascular function in preeclampsia.
Journal of molecular histologyPM2.5 exposure induces functional alterations in pregnant rats heart and in human stem cell derived cardiac spheroids.
Archives of toxicologyMetformin: An emerging therapeutic approach for prevention and treatment of preeclampsia.
European journal of obstetrics, gynecology, and reproductive biologyHematologic disorders in pregnancy: the role of the complement system.
Expert review of hematologyCorrigendum for "Oxygen and TGF-β1 jointly regulate fibronectin and trophoblast behavior highlighting a potential role for matrix signaling in severe preeclampsia" [Matrix Biology 144 (2026) 13-25].
Matrix biology : journal of the International Society for Matrix BiologyBilateral Purtscher-like retinopathy in pre-eclampsia secondary to HELLP syndrome.
Canadian journal of ophthalmology. Journal canadien d'ophtalmologieUltraprocessed foods consumption and risk of preeclampsia: a secondary analysis of the improving mothers for a better prenatal care trial Barcelona (IMPACT BCN) randomized clinical trial.
The American journal of clinical nutritionHypertensive Disorders of Pregnancy: A Systematic Review of International Clinical Practice Guidelines.
American journal of obstetrics and gynecologyThe Accuracy of the sFlt-1/PlGF Ratio Assay in Predicting Time to Delivery in Patients with Suspected Preeclampsia.
American journal of obstetrics and gynecologyStatement of retraction: maternal serum inhibin-A for predicting preeclampsia.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal ObstetriciansPerinatal use of targeted synthetic DMARDs and maternal-neonatal outcomes in autoimmune disease: A population-based cohort study.
Journal of autoimmunityCommunity awareness, perceptions, and management practices related to pre-eclampsia: An exploratory qualitative study in Mbale City, Eastern Uganda.
PloS oneMaternal and Fetal Outcomes in Early-Onset vs. Late-Onset Preeclampsia: A Retrospective Study at a Tertiary Care Institute in India.
CureusSevere Mitral Stenosis in Term Pregnancy Presenting During Labor in a Resource-Limited Setting: A Case Report from Borama, Awdal Region of Somalia.
International medical case reports journalGinsenoside Rb1 alleviates endothelial dysfunction and vascular remodeling in preeclampsia via activation of the PI3K-Akt-eNOS pathway.
Scientific reportsResearch trends in pre-eclampsia and exosomes from 2009 to 2023: a bibliometric analysis.
Computers in biology and medicineDiagnostic and prognostic role of maternal serum prokineticin-1 in preeclampsia and adverse pregnancy outcomes.
Journal of the Turkish German Gynecological AssociationA study protocol for a predictive model to assess population‑based risk of adverse pregnancy outcomes: The Adverse Pregnancy Outcomes Population Risk Tool (PregPoRT).
Diagnostic and prognostic researchAttention-deficit/hyperactivity disorder medication use and cardiometabolic conditions in pregnancy: a population-based cohort study.
Archives of women's mental healthMelatonin in Preeclampsia: a Systematic Review of its Role in Pathogenesis and Therapeutic Potential.
Reproductive sciences (Thousand Oaks, Calif.)Expert consensus on pre-eclampsia risk screening tools for low- and middle-income countries: Development of a new Target Product Profile.
PLOS global public healthProtocol for a process and implementation evaluation of the SMARThealth pregnancy hybrid type 2 cluster randomised controlled trial.
Women's health (London, England)Cardiovascular Disease and Pregnancy: Clinical Outcomes From a Tertiary Center Experience in Saudi Arabia.
Journal of the Saudi Heart AssociationInvestigation of Netrin-1 Levels in Maternal and Umbilical Cord Serum in Preeclampsia and Their Relationship With Vitamin D, Vitamin B12, and Folic Acid.
CureusEffectiveness of Prenatal Counselling on Physical and Psychological Well-Being Among Women With Preeclampsia at a Tertiary Care Hospital in India.
CureusMaternal Cardiac Arrest During Cesarean Section in the Setting of Severe Preeclampsia and Uncontrolled Type 1 Diabetes: A Case Report.
CureusDouble Jeopardy: The Intersection of COVID-19 and Pregnancy in an Educational Hospital, Northern Iran, Gorgan.
Archives of Razi InstituteThe virtual indigenous data science academy: development of a summer program in data science for tribal college students.
Frontiers in public healthEvaluation of extravascular lung water and cardiac function by intrapartum bedside ultrasound: full-term preeclampsia vs. healthy controls.
Frontiers in cardiovascular medicineIncidence of pre-eclampsia and its associated factors among pregnant women attending antenatal clinic at the 37 Military Hospital in Ghana.
BMJ nutrition, prevention & healthBuilding a foundation to promote Women's health research in Dubai. Study protocol for a project to investigate the feasibility of establishing a dedicated Women's health biobank.
Frontiers in global women's healthThe clinical value of nomogram combined with machine learning models in predicting the progression of hypertensive disorders in pregnancy to severe preeclampsia.
Frontiers in global women's healthDevelopment of a Triage Tool for Stratification and Referral of Women at Risk of Preeclampsia in Low-Resource Antenatal Settings: A Prospective Cohort Study.
Health science reportsPost-traumatic stress disorder and adverse pregnancy outcomes: sexual orientation disparities in a prospective cohort study.
BMC pregnancy and childbirth[Analysis of maternal and fetal outcomes and related factors of recurrence in women with a history of pre-eclampsia].
Zhonghua fu chan ke za zhiZFP36 inhibits trophoblast ferroptosis and attenuates preeclampsia development by promoting NCOA4 mRNA degradation and suppressing ferritinophagy.
Biochemical pharmacologyReduced syncytiotrophoblast-glycocalyx expression is associated with placental malperfusion and the severity of late-onset preeclampsia.
Pregnancy hypertensionFaecalibacterium prausnitzii: A microbial ally against preeclampsia via extracellular vesicle-mediated ferroptosis inhibition.
Free radical biology & medicineSTAT signaling pathway in pregnancy stages and related to complications.
Cellular immunologyAnalysis of stillbirth: a retrospective study in China.
Journal of perinatal medicineThe Predictive Value of P-Wave Dispersion and QTc Dispersion in Preeclampsia.
Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, IncConstruction and comparison of preeclampsia prediction models using logistic regression and machine learning.
BMC medical informatics and decision makingEffect of first-trimester aspirin initiation timing on obstetric outcomes: A comparative study.
MedicineIn Vitro Fertilization and Placenta Accreta (spectrum): A Systematic Review.
JBRA assisted reproductionBrazilian green propolis exerts anti-inflammatory effects on monocytes from women with early- and late-onset preeclampsia.
The Journal of pharmacy and pharmacologyAdverse Pregnancy Outcomes and Long-Term Risk of Chronic Diseases: Evidence from the Findings of the Tehran Lipid and Glucose Study During a Quarter of a Century.
International journal of endocrinology and metabolismClinical Characteristics and Maternal-Perinatal Outcomes of In Vitro Fertilization Patients Referred to a Hospital in Lima, Peru.
CureusThe Association Between Periconceptional Consumption of Ultra-Processed Food and the Incidence of Adverse Pregnancy Outcomes.
NutrientsMaternal and Neonatal Outcomes in Very Young Adolescent Pregnancies: A Single-Centre Retrospective Observational Study in Brașov, Romania.
Healthcare (Basel, Switzerland)Altered PAPP-A and Placental Thickness in Pre-Eclampsia and Intrauterine Growth Restriction: A Pilot Study.
Journal of clinical medicinePeripartum Depression as a Heart-Brain-Endocrine-Immune Syndrome: Neuroendocrine, Cardiovascular, and Inflammatory Pathways Underlying Maternal Vulnerability.
Life (Basel, Switzerland)Pre-Eclampsia-Induced Maternal Liver Dysfunction: Systematic Review, Meta-Analysis and Meta-Regression of Observation Studies.
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Research progress on histone epigenetic modifications in placental trophoblast syncytialization.
- Leveraging PANoptosis-associated genes for unraveling implication of decidualization deficiency in pre-eclampsia via transcriptome data and experiment validation.
- Long-term cardiac consequences of fetal exposure to preeclampsia: a speckle tracking echocardiography analysis.
- Hypertension action bundle including training of healthcare professionals to improve the detection of primary aldosteronism: a cohort study.
- Persistent entropy links irregularities in daily and weekly rest and activity cycles during gestation week 22 and 32 to maternal and neonate health outcomes: A prospective cohort study.
- Bedside Multimodal Ultrasonography for the Detection of Intracranial Hypertension in Severe Adolescent Preeclampsia: A Case Report and Screening Proposal.
- Cell-free mitochondrial DNA and microRNA-137 for early diagnosis of preeclampsia.
- From Maternal Exposure to Fetal Risk: Unraveling the PFAS Exposure Pathway and Its Placental Toxicity Mechanism.
- The effect of yoga on birth outcomes of Chinese pregnancies with preeclampsia.
- Revealing an enhanced cytotoxic immune microenvironment at the human maternal-fetal interface in preeclampsia.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:275555(Orphanet)
- MONDO:0005081(MONDO)
- GARD:12924(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
- Q61335(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
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