Síndrome agudo de radiação

BIO 300 Oral Powder Safety and Pharmacokinetics

NCT04650555

A Clinical Trial to Evaluate Safety, Tolerability and Pharmacokinetic/Pharmacodynamic Characteristics of KMRC011

NCT03585803

Safety and Tolerability of HemaMax™ (rHuIL-12) as Radiation Countermeasure

NCT01742221

Safety Study of HemaMax™ (rHuIL-12) to Treat Acute Radiation Syndrome

NCT02343133

Phase I Study of Eltrombopag for Promoting Thrombopoiesis After Total Body Irradiation

NCT00903929

NCT04650555 · BIO 300 Oral Powder Safety and PharmacokineticsConcluído

Pesquisa e ensaios clínicos

9 ensaios clínicos encontrados.

Distribuição por fase

NCT03585803 · A Clinical Trial to Evaluate Safety, Tolerability and Pharma…Concluído

NCT01742221 · Safety and Tolerability of HemaMax™ (rHuIL-12) as Radiation …Concluído

NCT02343133 · Safety Study of HemaMax™ (rHuIL-12) to Treat Acute Radiation…Concluído

PHASE2

NCT00903929 · Phase I Study of Eltrombopag for Promoting Thrombopoiesis Af…Concluído

NCT02587442 · A Study to Evaluate the Safety and Pharmacokinetics of RadPr…UNKNOWN

NCT00504335 · Safety and Pharmacokinetic Study of BIO 300 CapsulesConcluído

Ver todos no ClinicalTrials.gov

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Publicações mais relevantes

Timeline de publicações

580 papers (10 anos)

#1

Differential modulation of haematopoietic and oxidative injury by PARP-1 and ATR kinase inhibition in a murine model of acute irradiation.

PloS one2026

Temporal Modulation of Acute Radiation Injury by Post-Exposure PARP-1 versus ATR Kinase Inhibition. PARP-1 and ATR inhibitors have been employed as radiosensitizers in cancer therapy. In addition to this, there is little evidence about the role of these chemicals after a dose of radiation, specifically in relation to reducing damage to healthy cells rather than increasing it. The goal of this study was to determine if PARP-1 or ATR kinase inhibitors, when delayed administered, could decrease the severity of the condition caused by an acute dose of radiation and compare the impact of PARP-1 and ATR inhibitors. Mice of the C57BL/6 strain were subjected to a total body irradiation dose of 2.5 Gy γ-rays. In each experiment, thirty minutes following exposure to IR, either the PARP inhibitor, olaparib at 50 mg/kg or the ATR kinase inhibitor VE-821 at 25 mg/kg was injected intraperitoneally into the mice. The parameters of blood were measured at the same time as oxidative stress, including the activity of superoxide dismutase and levels of malondialdehyde. Examination of DNA damage and repair dynamics was done through the use of γ-H2AX immunofluorescence. Following exposure to ionising radiation, mice which had received a PARP inhibitor showed less marked haemoglobin reduction and less radiation-induced leucopenia than control mice exposed to radiation alone. The modifications were accompanied by a decrease in lipid peroxidation plus enhanced antioxidant activity. This observation that PARP inhibition enhances repair of DNA double-strand breaks is consistent with earlier data from other researchers. In contrast the protective effects of the ATR kinase inhibitor were not apparent when administered after the DNA damage had been inflicted in any of the parameters examined. While administering PARP inhibitors following the exposure to ionising radiation was found to reduce the severity of the condition experienced by the subject, as a result of acute radiation syndrome, the same was not seen when the treatment with ATR inhibitors was given to affected subjects. The results of this study show the significance of administering therapeutic agents at the right time to stop the injury to normal cells when DNA repair pathways are activated by exposure to ionising radiation.

#2

Breaking through the radiation dilemma: development and clinical translation of anti-radiation drugs.

Pharmaceutical science advances2026 Dec

The need for effective prevention and treatment of nuclear radiation injuries is underscored by historical nuclear incidents, ongoing challenges such as nuclear wastewater management, and the expanding use of radiation in medicine and industry. Despite the approval of a limited set of drugs such as potassium iodide, Prussian blue, cytokines for hematopoietic acute radiation syndrome (H-ARS), current countermeasures are hindered by a narrow scope of application, significant side effects, and a profound mechanistic knowledge gap. While novel drug development has expanded into various mechanisms such as targeting DNA damage repair and anti-inflammation, yielding promising directions like novel nano-delivery systems, the overall clinical translation rate remains low. To address these challenges, this review synthesizes literature from the past 3 decades with the following aims: (1) to provide an updated analysis of the molecular mechanisms of radiation injury, highlighting newly discovered targets; (2) to critically evaluate drugs across clinical, trial, and preclinical stages; and (3) to introduce a transformative paradigm. The application of artificial intelligence (AI) in drug discovery, is a prospect not systematically explored in prior reviews. We posit that integrating mechanistic insights with AI-driven approaches represents a promising path forward. Finally, we propose future directions aimed at overcoming the specific challenges facing AI in this field, including the development of strategies to mitigate model "black-box" effects, the establishment of secure and ethical frameworks for sharing sensitive radiation injury data, and the creation of specialized, high-quality databases to address the critical issue of data scarcity.

#3

Pre-Exposure Prophylaxis with Vasculotide Enhances Survival and Alleviates Hematopoietic and Gastrointestinal Injury Following Lethal Total Body Irradiation.

International journal of molecular sciences2026 Feb 19

No US Food and Drug Administration (FDA)-approved prophylaxis is currently available for Acute Radiation Syndrome (ARS), which remains a significant threat to military and civilian populations. In this study, we investigated Vasculotide (VT), a Tie2 receptor agonist mimic, as a novel pre-exposure prophylaxis designed to stabilize the vascular endothelium, one of primary targets of radiation-induced damage. To evaluate its efficacy, female B6D2F1/J mice were exposed to 9.5 Gy total body irradiation (TBI), with VT administered subcutaneously at 12 and 2 h prior to exposure. Assessments included 30-day survival, biomarkers of vascular injury, proinflammatory cytokine/chemokine profiling, and evaluation of hematopoietic (H) and gastrointestinal (GI) recovery. Our findings demonstrate that VT significantly increased 30-day survival in a dose-dependent manner, achieving a 30% survival advantage at the 20 μg/kg dose. Furthermore, VT provided robust protection against radiation-induced vascular activation and injury, effectively alleviating damage to the bone marrow (BM) and GI tract. Taken together, these results identify VT as a promising prophylactic countermeasure for ARS. By targeting the Tie2 pathway to preserve vascular integrity, VT addresses a critical gap in medical countermeasures, offering a viable strategy to enhance survival and accelerate multi-organ recovery in radiological mass-casualty scenarios.

#4

Single-Cell Profiling of ANKRD26 Thrombocytopenia Reveals Progenitor Expansion and Polyploid Apoptosis via JUNB-p21.

Blood2026 Jan 15

ANKRD26-related thrombocytopenia (THC2) is a rare inherited platelet disorder caused by germline variants in the 5' untranslated region (UTR) of ANKRD26. While prior studies using in vitro models or isolated case reports have suggested impaired megakaryopoiesis as a central mechanism, detailed insights have remained elusive-primarily due to the rarity, fragility, and heterogeneity of megakaryocytes. Here, we present a comprehensive, cross-validated analysis of bone marrow samples from four independent THC2 patients, integrating single-cell transcriptomics and ex vivo functional profiling. Across all patients, we analyzed CD34⁺ hematopoietic stem and progenitor cells (HSPCs) (47,281 THC2-HSPCs vs. 51,907 control cells) and primary megakaryocytes (pMKs) (7,309 THC2-pMKs vs. 5,077 controls), uncovering a consistent pattern of megakaryocyte progenitors (MkP) expansion and a marked reduction in polyploid megakaryocytes-indicating a conserved pathophysiologic phenotype. In our index patient, we identified the 5'UTR single-nucleotide variant in ANKRD26 that led to significantly elevated expression across four megakaryocyte-lineage subsets-spanning multipotent progenitors, common myeloid progenitors, megakaryocyte-erythroid progenitors, and MkPs-as well as in terminally enriched pMKs. Spatial transcriptomics and confocal imaging localized ANKRD26 to the centrosome, implicating it in mitotic regulation during megakaryocyte maturation. Mechanistically, we discovered that elevated ANKRD26 induces apoptosis in polyploid megakaryocytes via JUNB-mediated transcriptional activation of CDKN1A (p21)-operating independently of the canonical p53-PIDDosome axis. This multi-patient study provides the most comprehensive cellular and molecular portrait of ANKRD26-driven thrombocytopenia to date, offering novel insights into defective megakaryopoiesis and identifying candidate therapeutic targets to restore platelet production.

#5

Extracellular vesicles from mesenchymal stromal cells primed with synthetic toll-like receptor 4 agonists treat hematopoietic acute radiation syndrome.

Stem cells translational medicine2026 Jan 09

Whole-body exposure to ionizing radiation can lead to cellular DNA damage to bone marrow (BM), causing lethal hematopoietic acute radiation syndrome (H-ARS). Extracellular vesicles (EVs) from human BM-derived mesenchymal stromal cells were primed with CRX-527 (CRX), a synthetic TLR4 agonist, characterized and tested as a radiomitigator therapy. Using a xenogeneic H-ARS mouse model, a single in vivo treatment with CRX-EVs administered 4 or 24 hours after lethal irradiation significantly improved weight loss, clinical scores and prolonged survival compared to control treatments. Ex vivo generation of CRX-EV educated monocytes (CRX-EEMos) were also effective in a H-ARS model when administered 24 hours after lethal irradiation. CRX-EVs or CRX-EEMos significantly promoted hematopoiesis in BM and potentially the spleen, leading to restoration of peripheral complete blood counts. CRX-EEMos showed increased gene expression of IL-6 and IL-10: enriched for PD-L1 but low for CD16 in CD14-expressing monocytes. Antisense inhibition of Let-7 microRNAs in CRX-EEMos suppressed IL-10 gene expression and protein secretion, implicating a novel role for Let-7 in radioprotection. CRX-EVs can effectively treat H-ARS by increasing the secretion of anti-inflammatory molecules while stimulating monocytes to promote hematopoiesis in BM. The potential for large-scale production of CRX-EVs as an "off-the-shelf" treatment for H-ARS makes them a potential medical countermeasure for radiological and nuclear threats.

Publicações recentes

Impact of Dose Administration Schedule and Orthovoltage X-ray Beam Quality on Survival and Dose Response Relationships in C57BL/6J Mouse Models of Acute Radiation Syndrome.

Radiat Res2026 Apr 9

Design and synthesis of O-benzoyl amidoxime derivatives as novel TLR2/1 agonists with potent anti-radiation activity in mice.

Bioorg Med Chem2026 Jun

Integration of protein and metabolomic blood biomarkers enhances classification of radiation exposure in X-irradiated humanized mice.

Int J Radiat Biol2026 Mar 30

A Defined Patho-Mechanism for Acute Radiation Syndrome Death and a Three-Drug Regimen to Prevent It.

Int J Mol Sci2026 Mar 14

Radiomitigators: Breakthroughs in Post-Radiation Recovery.

Antioxidants (Basel)2026 Mar 18

Ver todas no PubMed

📚 EuropePMC314 artigos no totalmostrando 197

1,2-propanediol ameliorated radiation-induced intestinal injury in mice.

Differential modulation of haematopoietic and oxidative injury by PARP-1 and ATR kinase inhibition in a murine model of acute irradiation.

PloS one

Intelligent model for stratification of acute radiation syndrome severity in humans.

Pharmaceutical science advances

Breaking through the radiation dilemma: development and clinical translation of anti-radiation drugs.

Roxadustat induced fetal hemoglobin in anemic CKD patients: a dual-center real-world observational cohort study.

BMC nephrology

Characterization of the Sequence of Cytopenia after Total-body Irradiation using Unsupervised Machine Learning.

Pre-Exposure Prophylaxis with Vasculotide Enhances Survival and Alleviates Hematopoietic and Gastrointestinal Injury Following Lethal Total Body Irradiation.

Current issues in molecular biology

A Review of Ionizing Radiation-Induced Senescence of Bone Marrow Mesenchymal Stem/Stromal Cells: Mechanisms and Therapeutic Strategies.

Glutamine alleviates radiation-induced intestinal injury in rats via the mTOR/Notch1 axis.

Frontiers in oncology

Meeting the Challenges of Cytokine Administration During Nuclear Incident Response.

HYPERCORTICISM IN THE PATHOGENESIS OF ACUTE RADIATION SICKNESS AND CONDITIONS OF INCREASED RADIORESISTANCE.

Georgian medical news

Journal of radiological protection : official journal of the Society for Radiological Protection

Cytokine use in the hematopoietic subsyndrome of acute radiation syndrome (H-ARS): implications for the role of cytokines in a mass casualty radiologic/nuclear (R/N) emergency.

Bone Marrow Colony Stimulating Factors (CSF) and Stem Cell Therapy as Medical Countermeasures (MCM) for Treatment of Hematopoietic-Acute Radiation Syndrome: A Systematic Review.

Influence of Cell Size Changes after Irradiation on Reliability of an Impedance Measurement-based Hematology Analyzer.

Life (Basel, Switzerland)

Radioprotective Effect of ε-Aminocaproic Acid in Acute Total-Body Gamma Irradiation in Rats.

Development of an Extended-release Formulation of Radioprotectin-1 for Mitigation of Gastrointestinal Acute Radiation Syndrome.

Single-Cell Profiling of ANKRD26 Thrombocytopenia Reveals Progenitor Expansion and Polyploid Apoptosis via JUNB-p21.

Blood

Stem cells translational medicine

Extracellular vesicles from mesenchymal stromal cells primed with synthetic toll-like receptor 4 agonists treat hematopoietic acute radiation syndrome.

Evaluation of CBC-derived inflammatory markers in Wistar rats exposed to high-dose whole-body X-ray irradiation.

Rapid Radiation Dose Estimation Techniques for Initial Patient Triage.

Health physics

Molecular medicine (Cambridge, Mass.)

Ghrelin mitigates partial body irradiation-induced gastrointestinal acute radiation syndrome by promoting intestinal stem cell regeneration.

European approach for acute radiation syndrome's management facing radiological and nuclear threats: A call for arms - CORRIGENDUM.

Annals of African medicine

A Case Report on Glaucoma and Anterior Segment Abnormalities in Axenfeld-Rieger Syndrome.

Frontiers in pharmacology

Radioprotection redefined: drug discovery at the intersection of tardigrade biology and translational pharmacology.

Senescent SPP1+ macrophages remodel the tumor microenvironment and promote the progression of early-stage lung adenocarcinoma featured with mixed ground glass nodule.

Molecular cancer

Current issues in molecular biology

The Complex Role of MAPK/ERK Signaling Pathway in Different Types of Thrombocytopenia.

A multi-omics approach exploring the gut-liver axis following combined radiation exposure and burn injury in a Sinclair minipig model.

Applicability of a four-gene set for H-ARS severity prediction in peripheral blood samples of irradiated minipigs.

Programmable no-nonspecific genetic analytical system via dual-circle-based rolling circle amplification with an efficient CRISPR/Cas12a biosensing strategy.

European Approach for Acute Radiation Syndrome's Management Facing Radiological and Nuclear Threats: A Call for Arms.

Animal models and experimental medicine

Radiation emergency medical countermeasures: Current formulary, identified gaps, and future approaches.

Dose Optimization and Receptor Utilization of Prostaglandin E Analogs for Radioprotection and Radiomitigation of H-ARS and DEARE.

Spleen Transcriptome of Nonhuman Primates Exposed to High Doses of Total- or Partial-Body Radiation: Comparisons with Jejunum and Lung.

Metabolic alterations in erythrocytes associated with long-term hypoxia at high altitude.

BMC genomics

Mitigation of Radiation-induced Cardiotoxicity by Subcutaneous "Protective Wounding".

Development of PLX-R18, a promising and novel countermeasure for radiation-associated injuries.

Drug discovery today

Human bone marrow niche organoids for disease modeling and therapeutic application in hematopoietic syndrome.

Biomaterials

International journal of laboratory hematology

Transcriptome Analysis Identifies Functional and Prognostic Hypoxia-Associated Genes in Multiple Myeloma.

Adult Medical Countermeasures: Antidotes and Cytokines for Radiological and Nuclear Incidents and Terrorism.

Analysis of the Metabolomic Profile in Serum of Mice Treated with RadioDefender, a Novel Radiation Medical Countermeasure.

Prophylactic Administration of BIO 300, A Radiation Medical Countermeasure, Improves Erythrocyte-Associated Parameters in the Rhesus Macaque Model.

Military medicine

International journal of radiation oncology, biology, physics

Activation of Angiotensin-Converting Enzyme 2 Mitigates Gastrointestinal Acute Radiation Syndrome.

Abscopal Brain Proteomic Changes Associated with Microbiome Alterations Induced by Gastrointestinal Acute Radiation Syndrome in Swine.

16,16 dimethyl-prostaglandin E2 Administration Prior to Lethal Irradiation Ameliorates Long-term Immune Suppression.

Advanced functional materials

Development of Nanocarrier-Based Oral Pegfilgrastim Formulations for Mitigating Hematopoietic Acute Radiation Syndrome.

International immunopharmacology

Eriocalyxin B confers radioprotection of hematopoietic stem and progenitor cells via granulocyte colony-stimulating factor induction.

Advanced Medical Countermeasures and Devices for Use During a Radiological or Nuclear Emergency.

Comparison of sensitivity of rhesus and cynomolgus macaque for acute radiation effects.

Expert opinion on drug discovery

New opportunities and current challenges using animal models for the discovery of novel countermeasures for acute radiation syndrome.

Bone marrow-targeted thrombopoietin delivery via engineered platelet-derived vesicle-loaded dissolving microneedles for treating ionizing radiation-induced injury.

Materials today. Bio

Balancing Regeneration and Resistance: Targeting DCLK1 to Mitigate Gastrointestinal Radiation Injury and Oncogenesis.

Cancers

Plasma and Fecal Metabolites Combined with Gut Microbiome Reveal Systemic Metabolic Shifts in 60Co Gamma-Irradiated Rats.

Metabolites

Cell death and iron deposition in the liver in two murine models of acute radiation syndrome.

PloS one

Preconditioning with Rapamycin Improves Therapeutic Potential of Placenta-Derived Mesenchymal Stem Cells in Mouse Model of Hematopoietic Acute Radiation Syndrome.

Imidazolyl ethanamide pentandioic acid promotes hematopoietic recovery following sublethal radiation in a murine model.

Radiosensitizing the SUMO stress response intensifies single-dose radiotherapy tumor cure.

JCI insight

Gastrointestinal acute radiation syndrome: current knowledge and perspectives.

Cell death discovery

Identification of Potential Prophylactic Medical Countermeasures Against Acute Radiation Syndrome (ARS).

Characterization of Two Stable Biodosimeters for Absorbed Ionizing Radiation Dose Estimation in Multiple Combined Injury Models.

Stem cell research & therapy

DSUP modified mesenchymal stem cells exert significant radiation protective effect by enhancing the hematopoietic niche.

The Radioprotective Effects of 16, 16 dimethyl Prostaglandin E2 on Survival and Hematopoiesis are Mediated Through Co-Stimulation of the EP3 and EP4 Receptors.

Raffinose-metabolizing bacteria impair radiation-associated hematopoietic recovery via the bile acid/FXR/NF-κB signaling pathway.

Gut microbes

Medical oncology (Northwood, London, England)

Mesoporous polydopamine nanoparticles coated with metal-polyphenol networks for demethylation therapy of lung cancer.

Identifying radiation-induced symptoms from an interview survey.

Lethality Assessments for Acutely Irradiated Cynomolgus Macaques Under Subject-based Care.

Best practice & research. Clinical haematology

Cytokine therapy of acute radiation syndrome.

Mitochondrial uncoupler 2,4-dinitrophenol (DNP) confers protection from the acute effect of ionizing radiation by regulating redox homeostasis in radio-sensitive organs of C57BL/6 mice.

Journal of inflammation research

Dual Role of α-MSH in Colitis Progression: Mediating Neutrophil Differentiation via Bone Marrow.

Cell death and differentiation

STING directly interacts with PAR to promote apoptosis upon acute ionizing radiation-mediated DNA damage.

MIIST305 mitigates gastrointestinal acute radiation syndrome injury and ameliorates radiation-induced gut microbiome dysbiosis.

Gut microbes

Central Nervous System Response Against Ionizing Radiation Exposure: Cellular, Biochemical, and Molecular Perspectives.

Molecular neurobiology

Pharmacokinetic and Metabolomic Studies with BBT-059 in Nonhuman Primates Exposed to Total-Body Gamma Radiation.

Military Medical Research

Dietary methionine supplementation promotes mice hematopoiesis after irradiation.

N-acetyl-L-tryptophan provides radioprotection to mouse and primate models by antagonizing the TRPV1 receptor and substance P inhibition.

Cell-based and extracellular vesicle-based MSC therapies for acute radiation syndrome affecting organ systems.

Advanced healthcare materials

Radiation-Resistant Bacteria Deinococcus radiodurans-Derived Extracellular Vesicles as Potential Radioprotectors.

International journal of microbiology

Alterations in Gut Microbiota Correlate With Hematological Injuries Induced by Radiation in Beagles.

bioRxiv : the preprint server for biology

Transcriptome of the murine duodenum during recovery after a lethal dose of total body irradiation.

Management of Casualties from Radiation Events.

European burn journal

IEPA, a novel radiation countermeasure, alleviates acute radiation syndrome in rodents.

International journal of laboratory hematology

Clinical Significance of Complement and Coagulation Cascades Genes for Patients With Acute Lymphoblastic Leukemia.

Nanoradiosentizers with X ray-actuatable supramolecular aptamer building units for programmable immunostimulatory T cell engagement.

Biomaterials

X-ray Fluorescence Microscopy to Develop Elemental Classifiers and Investigate Elemental Signatures in BALB/c Mouse Intestine a Week after Exposure to 8 Gy of Gamma Rays.

Advanced Electrospun Composites Based on Polycaprolactone Fibers Loaded with Micronized Tungsten Powders for Radiation Shielding.

Polymers

Pharmaceuticals (Basel, Switzerland)

Dehydroepiandrosterone and Its Metabolite 5-Androstenediol: New Therapeutic Targets and Possibilities for Clinical Application.

Interleukin-12 sustained release system promotes hematopoietic recovery after radiation injury.

MedComm

Molecular biology reports

Histone deacetylase inhibitor, Trichostatin A mitigates ionizing radiation induced redox imbalance by regulating NRF2/GPX4/PINK1/PARKIN signaling in mice intestine.

Mitigating the Effects of 1-Palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol on Gastrointestinal Acute Radiation Syndrome after Total-Body Irradiation in Mice.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Anti-Ceramide ScFv Prophylaxis for First Responders to a Limited Nuclear Attack.

Preliminary Promising Findings for Manganese Chloride as a Novel Radiation Countermeasure Against Acute Radiation Syndrome.

Military medicine

BIO 300: A Prophylactic Radiation Countermeasure for Acute Radiation Syndrome.

Military medicine

Significant Reduction of Radiation-Induced Death in Mice Treated with PrC-210 and G-CSF after Irradiation.

Effect of Age at Time of Irradiation, Sex, Genetic Diversity, and Granulopoietic Cytokine Radiomitigation on Lifespan and Lymphoma Development in Murine H-ARS Survivors.

Assessing the Mental Model State of Emergency Responders in the Context of Radiological Dispersal Device (RDD) Incidents: A Multi-state Study.

Health physics

Biomarkers for Radiation Biodosimetry and Correlation with Hematopoietic Injury in a Humanized Mouse Model.

Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine

Management of acute radiation syndrome.

MICROBIOME AND INFLAMMASOME ALTERATIONS FOUND DURING RADIATION DOSE FINDING IN A SINCLAIR MINIPIG MODEL OF GASTROINTESTINAL ACUTE RADIATION SYNDROME.

Shock (Augusta, Ga.)

Cell Therapies for Acute Radiation Syndrome.

Stem cell reviews and reports

Role of Neurotransmitters in Steady State Hematopoiesis, Aging, and Leukemia.

An Overview of Appropriate Medical Practice and Preparedness in Radiation Emergency Response.

Cureus

An Overview of Radiation Countermeasure Development in Radiation Research from 1954 to 2024.

Frontiers in public health

Effects of radiation mitigating amino acid mixture on mice of different sexes.

Proteomic analysis of plasma at the preterminal stage of rhesus nonhuman primates exposed to a lethal total-body dose of gamma-radiation.

Pathology of acute sub-lethal or near-lethal irradiation of nonhuman primates prophylaxed with the nutraceutical, gamma tocotrienol.

World journal of stem cells

GATA binding protein 2 mediated ankyrin repeat domain containing 26 high expression in myeloid-derived cell lines.

Frontiers in public health

Effects of combined ciprofloxacin and Neulasta therapy on intestinal pathology and gut microbiota after high-dose irradiation in mice.

Annals of plastic surgery

Assessment of Hematopoietic Response to Total Body Irradiation in a Rat Experimental Model.

Archivum immunologiae et therapiae experimentalis

Transplantation of Donor-Recipient Chimeric Cells Restores Peripheral Blood Cell Populations and Increases Survival after Total Body Irradiation-Induced Injury in a Rat Experimental Model.

Serum sSelectin-L is an early specific indicator of radiation injury.

Heliyon

Stem cells and development

Donor-Recipient Chimeric Cell Transplantation as the Bridging Therapy for Mitigating Total Body Irradiation-Induced Injury.

Rethinking the Role of Biodosimetry to Assess Risks for Acute Radiation Syndrome in Very Large Radiation Events: Reconsidering Legacy Concepts.

Pharmacokinetic and Metabolomic Studies with a Promising Radiation Countermeasure, BBT-059 (PEGylated interleukin-11), in Rhesus Nonhuman Primates.

FG-4592 protected haematopoietic system from ionising radiation in mice.

Immunology

Stem cell research & therapy

Thrombopoietin mimetic stimulates bone marrow vascular and stromal niches to mitigate acute radiation syndrome.

Medicina (Kaunas, Lithuania)

Health Effects of Ionizing Radiation on the Human Body.

Ferroptosis, Inflammation, and Microbiome Alterations in the Intestine in the Göttingen Minipig Model of Hematopoietic-Acute Radiation Syndrome.

Gastrointestinal Acute Radiation Syndrome: Mechanisms, Models, Markers, and Medical Countermeasures.

Frontiers in public health

Delayed effects of radiation exposure in a C57L/J mouse model of partial body irradiation with ~2.5% bone marrow shielding.

Acute Impacts of Ionizing Radiation Exposure on the Gastrointestinal Tract and Gut Microbiome in Mice.

European journal of medicinal chemistry

Radioprotective effectiveness of a novel delta-tocotrienol prodrug on mouse hematopoietic system against 60Co gamma-ray irradiation through inducing granulocyte-colony stimulating factor production.

Development of a Point-of-Care Microfluidic RNA Extraction Slide for Gene Expression Diagnosis after Irradiation.

Novel Perspectives on Thrombopoietin Receptor Agonists Applications.

Hamostaseologie

Applicability of Gene Expression in Saliva as an Alternative to Blood for Biodosimetry and Prediction of Radiation-induced Health Effects.

Stem cell research & therapy

Large-scale bioreactor production of extracellular vesicles from mesenchymal stromal cells for treatment of acute radiation syndrome.

Effects of Hemorrhage on Hematopoietic Cell Depletion after a Combined Injury with Radiation: Role of White Blood Cells and Red Blood Cells as Biomarkers.

Validating a Four-gene Set for H-ARS Severity Prediction in Peripheral Blood Samples of Irradiated Rhesus Macaques.

Histopathological studies of nonhuman primates exposed to supralethal doses of total- or partial-body radiation: influence of a medical countermeasure, gamma-tocotrienol.

Biochemical and biophysical research communications

Sequential administration of delta-tocotrienol ameliorates radiation-induced myelosuppression in mice and non-human primates through inducing G-CSF production.

Product Development within the National Institutes of Health Radiation and Nuclear Countermeasures Program.

Serum microRNA profile of rhesus macaques following ionizing radiation exposure and treatment with a medical countermeasure, Ex-Rad.

Molecules (Basel, Switzerland)

Fluacrypyrim Protects Hematopoietic Stem and Progenitor Cells against Irradiation via Apoptosis Prevention.

Development of a Radiation-induced Pulmonary Fibrosis Partial Body Irradiation Model in C57BL/6 Mice.

FSL-1: A Synthetic Peptide Increases Survival in a Murine Model of Hematopoietic Acute Radiation Syndrome.

DAMPs and radiation injury.

Frontiers in immunology

Natural-history Characterization of a Murine Partial-body Irradiation Model System: Establishment of a Multiple-Parameter Based GI-ARS Severity-Scoring System.

Knowledge, Attitude and Awareness of Oman Emergency Physicians and Residents Regarding Radiation Emergencies - CORRIGENDUM.

The Influence of Computed Tomography Contrast Agent on Radiation-Induced Gene Expression and Double-Strand Breaks.

Knowledge, Attitude and Awareness of Oman Emergency Physicians and Residents Regarding Radiation Emergencies.

Validation of genes for H-ARS severity prediction in leukemia patients - interspecies comparison, challenges, and promises.

Chronic Ouabain Targets Pore-Forming Claudin-2 and Ameliorates Radiation-Induced Damage to the Rat Intestinal Tissue Barrier.

Trauma surgery & acute care open

Blood product use for radiological/nuclear trauma: product development and US regulatory considerations.

Development of Drug Products for the Treatment of Acute Radiation Syndrome.

Problemy radiatsiinoi medytsyny ta radiobiolohii

ACUTE RADIATION SICKNESS IN HUMAN: ETIOPATHOGENESIS, CLINIC, DIAGNOSIS AND TREATMENT (LECTURE).

The potential value of 5-androstenediol in countering acute radiation syndrome.

Drug discovery today

Bulletin of experimental biology and medicine

Humanized Mice as a Model to Assess the Response of Human Hematopoietic Stem Cells to Irradiation.

Proceedings of the National Academy of Sciences of the United States of America

The TLR2/TLR6 ligand FSL-1 mitigates radiation-induced hematopoietic injury in mice and nonhuman primates.

Pharmacokinetics and Biodistribution of 16,16 dimethyl Prostaglandin E2 in Non-Irradiated and Irradiated Mice and Non-Irradiated Non-Human Primates.

Development of a Multi-Organ Radiation Injury Model with Precise Dosimetry with Focus on GI-ARS.

An Experimental Model of Proton-Beam-Induced Radiation Dermatitis In Vivo.

Role of microbiota in radiation-induced small-bowel damage.

Sex differences in radiation research.

Iron Deposition in the Bone Marrow and Spleen of Nonhuman Primates with Acute Radiation Syndrome.

Mitigation of acute radiation syndrome (ARS) with human umbilical cord blood.

Histological assessment of intestinal injury by ionizing radiation.

Methods in cell biology

International journal of radiation oncology, biology, physics

Prediction of Acute Radiation-Induced Lung Toxicity After Stereotactic Body Radiation Therapy Using Dose-Volume Parameters From Functional Mapping on Gallium 68 Perfusion Positron Emission Tomography/Computed Tomography.

Overlapping Science in Radiation and Sulfur Mustard Exposures of Skin and Lung: Consideration of Models, Mechanisms, Organ Systems, and Medical Countermeasures: Overlapping science in radiation and sulfur mustard injuries to lung and skin.

Humanized mouse models for inherited thrombocytopenia studies.

Platelets

International journal of radiation oncology, biology, physics

Anti-ceramide Single-Chain Variable Fragment Mitigates Gastrointestinal-Acute Radiation Syndrome and Improves Marrow Reconstitution, Rendering Near-Normal 90-Day Autopsies.

CR6-Interacting Factor-1 Promotes Osteoclastogenesis Through the NF-κB Signaling Pathway after Irradiation.

Expert review of proteomics

Protein biomarkers for radiation injury and testing of medical countermeasure efficacy: promises, pitfalls, and future directions.

International journal of radiation oncology, biology, physics

Racecadotril Versus Loperamide in Acute Radiation Enteritis: A Randomized, Double-Masked, Phase 3, Noninferiority Trial.

Cytogenetic and genome research

The NIAID/RNCP Biodosimetry Program: An Overview.

PEGylated thrombopoietin mimetic, JNJ‑26366821 a novel prophylactic radiation countermeasure for acute radiation injury.

Pharmacokinetic and Pharmacodynamic Bioequivalence of Pegfilgrastim-cbqv Delivered via a Prefilled Autoinjector and Prefilled Syringe in Healthy Male Participants.

Advances in therapy

Therapeutic mechanism of Liangxue-Guyuan-Yishen decoction on intestinal stem cells and tight junction proteins in gastrointestinal acute radiation syndrome rats.

Evaluating transport conditions of conventional, widely used EDTA blood tubes for gene expression analysis in comparison to expensive, specialized PAXgene tubes in preparedness for radiological and nuclear events.

Animal models and experimental medicine

Development of radiation countermeasure agents for acute radiation syndromes.

Expert opinion on drug safety

United States' regulatory approved pharmacotherapies for nuclear reactor explosions and anthrax-associated bioterrorism.

MedEdPORTAL : the journal of teaching and learning resources

Employing High-Fidelity Simulation for the High-Risk, Low-Frequency Diagnosis and Management of Acute Radiation Syndrome (ARS).

Antioxidants (Basel, Switzerland)

PrC-210 Protects against Radiation-Induced Hematopoietic and Intestinal Injury in Mice and Reduces Oxidative Stress.

Involvement of extracellular vesicles in the progression, diagnosis, treatment, and prevention of whole-body ionizing radiation-induced immune dysfunction.

Frontiers in immunology

Open-Source Intelligence for Detection of Radiological Events and Syndromes Following the Invasion of Ukraine in 2022: Observational Study.

JMIR infodemiology

Cytogenetic and genome research

Sex as a Factor in Murine Radiation Research: Implications for Countermeasure Development.

Radiation protection dosimetry

Assessment of uncertainties in threshold doses for tissue reactions following acute external radiation exposure.

Radiation Injuries: Acute Radiation Syndrome in Children.

Pediatric annals

Biological sex differences in renin angiotensin system enzymes ACE and ACE2 regulate normal tissue response to radiation injury.

Frontiers in physiology

Frontiers in pharmacology

Blocking TRAIL-DR5 signaling pathway with soluble death receptor 5 fusion protein mitigates radiation-induced injury.

Proteomics and secreted lipidomics of mouse-derived bone marrow cells exposed to a lethal level of ionizing radiation.

The Acute Radiation Syndrome-Mitigator Romiplostim and Secreted Extracellular Vesicles Improved Survival in Mice Acutely Exposed to Myelosuppressive Doses of Ionizing Radiation.

Biomolecules

Cytogenetic and genome research

Radiation-Induced Gene Expression Changes Used for Biodosimetry and Clinical Outcome Prediction: Challenges and Promises.

Translational neurodegeneration

An open-label multiyear study of sargramostim-treated Parkinson's disease patients examining drug safety, tolerability, and immune biomarkers from limited case numbers.

Transcriptome profile changes in the jejunum of nonhuman primates exposed to supralethal dose of total- or partial-body radiation.

BMC genomics

Severity scoring systems for radiation-induced GI injury - prioritization for use of GI-ARS medical countermeasures.

Effects of Chinese herbal diet on hematopoiesis, immunity, and intestines of mice exposed to different doses of radiation.

Heliyon

Plasma metabolomic signatures from patients following high-dose total body irradiation.

Molecular omics

Expert opinion on drug discovery

Radiosensitivity of rhesus nonhuman primates: consideration of sex, supportive care, body weight, and age at time of exposure.

Further Characterization of Multi-Organ DEARE and Protection by 16,16 Dimethyl Prostaglandin E2 in a Mouse Model of the Hematopoietic Acute Radiation Syndrome.

Release of Interferon-β (IFN-β) from Probiotic Limosilactobacillus reuteri-IFN-β (LR-IFN-β) Mitigates Gastrointestinal Acute Radiation Syndrome (GI-ARS) following Whole Abdominal Irradiation.

Cancers

Journal of proteome research

Analysis of the Proteomic Profile in Serum of Irradiated Nonhuman Primates Treated with Ex-Rad, a Radiation Medical Countermeasure.

Combined radiation injury and its impacts on radiation countermeasures and biodosimetry.

Longitudinal multi-omic changes in the transcriptome and proteome of peripheral blood cells after a 4 Gy total body radiation dose to Rhesus macaques.

BMC genomics

The progression of radiation injury in a Wistar rat model of partial body irradiation with ∼5% bone marrow shielding.

The delayed effects of acute radiation exposure (DEARE): characteristics, mechanisms, animal models, and promising medical countermeasures.

A C57L/J Mouse Model of the Delayed Effects of Acute Radiation Exposure in the Context of Evolving Multi-Organ Dysfunction and Failure after Total-Body Irradiation with 2.5% Bone Marrow Sparing.

Molecules (Basel, Switzerland)

rhTPO Ameliorates Radiation-Induced Long-Term Hematopoietic Stem Cell Injury in Mice.

Cytosolic Release of Mitochondrial DNA and Associated cGAS Signaling Mediates Radiation-Induced Hematopoietic Injury of Mice.

Where are the medical countermeasures against the ARS and DEARE? A current topic relative to an animal model research platform, radiation exposure context, the acute and delayed effects of acute exposure, and the FDA animal rule.

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