A síndrome autoimune à insulina é uma doença rara que causa um nível baixo de açúcar no sangue (hipoglicemia). Isso acontece porque o corpo começa a produzir um tipo específico de proteína, chamadas anticorpos, para atacar a insulina. A insulina é um hormônio natural responsável por manter o açúcar no sangue em um nível normal. Quando o açúcar no sangue fica muito alto, a insulina ajuda a guardar esse açúcar para ser usado depois. Pessoas com a síndrome autoimune à insulina têm anticorpos que atacam a insulina, fazendo com que ela trabalhe demais e o nível de açúcar no sangue caia excessivamente. A síndrome autoimune à insulina geralmente começa na fase adulta.
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A síndrome autoimune à insulina é uma doença rara que causa um nível baixo de açúcar no sangue (hipoglicemia). Isso acontece porque o corpo começa a produzir um tipo específico de proteína, chamadas anticorpos, para atacar a insulina. A insulina é um hormônio natural responsável por manter o açúcar no sangue em um nível normal. Quando o açúcar no sangue fica muito alto, a insulina ajuda a guardar esse açúcar para ser usado depois. Pessoas com a síndrome autoimune à insulina têm anticorpos que atacam a insulina, fazendo com que ela trabalhe demais e o nível de açúcar no sangue caia excessivamente. A síndrome autoimune à insulina geralmente começa na fase adulta.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 4 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 13 características clínicas mais associadas, ordenadas por frequência.
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Os sinais que médicos procuram e os exames que confirmam
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AACE clinical case reportsLow-carbohydrate diet combined with SGLT2 inhibitor for refractory hyperglycemia caused by insulin antibodies.
Diabetes research and clinical practice[Insulin autoimmune syndrome].
Nihon rinsho. Japanese journal of clinical medicineTwo Sisters with Graves' Disease and Similar Clinical Features who Tested Positive for Anti-insulin Antibodies after Thiamazole Treatment.
Internal medicine (Tokyo, Japan)The insulin autoimmune syndrome (IAS) as a cause of hypoglycaemia: an update on the pathophysiology, biochemical investigations and diagnosis.
Clinical chemistry and laboratory medicineNovel Management of Insulin Autoimmune Syndrome with Rituximab and Continuous Glucose Monitoring.
The Journal of clinical endocrinology and metabolismSpontaneous hypoglycemia: diagnostic evaluation and management.
EndocrineInsulin autoimmune syndrome during the administration of clopidogrel.
Journal of diabetesRare association of insulin autoimmune syndrome with ankylosing spondylitis.
Endocrinology, diabetes & metabolism case reports[Insulin autoimmune syndrome: Report of two cases].
Revista medica de ChileInsulin Autoimmune Syndrome: 73 Cases of Clinical Analysis.
Chinese medical journalUnusual Manifestations of Essential Monoclonal Gammopathy. II. Simulation of the Insulin Autoimmune Syndrome.
Rambam Maimonides medical journalClinical features and causes of endogenous hyperinsulinemic hypoglycemia in Korea.
Diabetes & metabolism journalA case of hypothalamic hypopituitarism accompanied by recurrent severe hypoglycemia.
SpringerPlusAssociações
Organizações que acompanham esta doença — pra ter apoio e orientação
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Comunidades
Grupos ativos de quem convive com esta doença aqui no Raras
Ainda não existe comunidade no Raras para Síndrome autoimune da insulina
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Clinical Characteristics and Risk Factors of Exogenous Insulin Antibody Syndrome in Patients with Diabetes: A Retrospective Cross-Sectional Study.
- A Case of Antibody-Mediated Recurrent Hypoglycemia in a Patient With Mixed Connective Tissue Disease.
- Insulin Autoimmune Syndrome Associated With Hashimoto Thyroiditis and Nodular Thyroid Disease: Clinical Management With Flash Glucose Monitoring and Prednisolone Therapy.
- Diagnostic efficacy of fasting insulin-to-C-peptide ratio in exogenous insulin autoimmune syndrome.
- Ovarian stimulation toward oocyte cryopreservation for fertility preservation in a patient with Hirata syndrome: a clinical challenge in assisted reproduction.
- Discordant Cortisol Responses to Spontaneous Hypoglycaemia Versus Adrenocorticotropic Hormone Stimulation: A Diagnostic Challenge for Hypothalamic-Pituitary-Adrenal Axis Assessment.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:411593(Orphanet)
- MONDO:0018465(MONDO)
- GARD:10808(GARD (NIH))
- Busca completa no PubMed(PubMed)
- Q55009198(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
