G-quadruplexes regulate chromatin accessibility and gene expression in Bloom Syndrome.

Metastatic Pancreatic Adenocarcinoma with Germline BLM and Somatic ATM Mutations: A Case Report and Review of DNA Damage Response.

Mitotic BLM functions are required to maintain genomic stability.

Prognostic Significance of DNA Repair Gene mRNA Expression in Early-Stage Breast Cancer: Insights into Clinical Relevance.

Unraveling syndrome-driven osteosarcoma: genetic insights and therapeutic frontiers.

Inhibition of BLM helicase disrupts organelle function and oocyte maturation in goats.

Prenatal Diagnosis of Bloom Syndrome Associated With Biallelic BLM RecQ-Like Helicase Variants Presenting With Severe Fetal Growth Restriction.

BLM and FANCJ role in the response to G-quadruplex-dependent telomeric replicative stress.

Withdrawal Note: KNO1-mediated autophagic degradation of the Bloom syndrome complex component RMI1 promotes homologous recombination.

The Relationship Between Insulin Resistance and Cancer in Humans.

Cardiac transplant outcomes in a pediatric patient with novel homozygous variants in TOP3Α causing mitochondrial dysfunction.

Target-triggered G-quadruplex DNAzyme on electrospun nanofibrous films for multicolor visual detection of uracil-DNA glycosylase.

DNA repair helicases: from mechanistic understanding to therapeutic implications.

Membrane-coated BLM gene silencing plasmids and doxorubicin nanoparticles targeted for synergistic inhibition of triple-negative breast cancer.

Shared and non-overlapping functions of RECQL4 and BLM helicases in chemotherapeutics-induced glioma cell responses.

Telomeric SUMO level influences the choices of APB formation pathways and ALT efficiency.

Centromere protection requires strict mitotic inactivation of the Bloom syndrome helicase complex.

Palliative Chemotherapy is Well Tolerated in a Patient With Metastatic Colorectal Cancer Due to Bloom Syndrome With a Novel BLM Mutation.

Distinct mechanisms underlying extrachromosomal telomere DNA generation in ALT cancers.

An overview of RecQ helicases and related diseases.

Management of Paediatric Cancers Associated With Bloom Syndrome.

Irinotecan alleviates chemoresistance to anthracyclines through the inhibition of AARS1-mediated BLM lactylation and homologous recombination repair.

Successful Haploidentical Haematopoietic Stem Cell Transplant in a Rare Case of Bloom Syndrome Associated With Monosomy 7/MDS.

CTC1-STN1-TEN1 controls DNA break repair pathway choice via DNA end resection blockade.

Mechanistic insight into anaphase bridge signaling to the abscission checkpoint.

Arsenic enhances cervical cancer cell radiosensitivity by suppressing the DNA damage repair pathway.

Condensin II interacts with BLM helicase in S phase to maintain genome stability.

A CPC-shelterin-BTR axis regulates mitotic telomere deprotection.

Multiple functions of the ALT favorite helicase, BLM.

Unilateral posterior subcapsular cataract and lenticonus in a girl with Bloom's syndrome - report of a rare case.

Biophysical investigation of the molecular interaction between minichromosome maintenance protein 6 and Bloom syndrome helicase.

Phosphorylated BLM peptide acts as an agonist for DNA damage response.

BLM knockdown promotes cells autophagy via p53-AMPK-mTOR pathway in triple negative breast cancer cells.

The BLM-TOP3A-RMI1-RMI2 proximity map reveals that RAD54L2 suppresses sister chromatid exchanges.

Functions of the Bloom syndrome helicase N-terminal intrinsically disordered region.

Single-Molecule Visualization of BLM-DNA2-Mediated DNA End Resection Using DNA Curtains.

Ustilago maydis Trf2 ensures genome stability by antagonizing Blm-mediated telomere recombination: Fine-tuning DNA repair factor activity at telomeres through opposing regulations.

Rare Causes and Differential Diagnosis in Patients With Silver-Russell Syndrome.

THE BLOOM SYNDROME AND RETINOBLASTOMA PATIENT EXHIBITS TWO RB1 GENE MUTATIONS IN THE GERMLINE.

The cGAS-STING pathway is an in vivo modifier of genomic instability syndromes.

Synergistic effects of bloom helicase (BLM) inhibitor AO/854 with cisplatin in prostate cancer.

Update on Recommendations for Cancer Screening and Surveillance in Children with Genomic Instability Disorders.

Promotion of DNA end resection by BRCA1-BARD1 in homologous recombination.

Mechanism of BRCA1-BARD1 function in DNA end resection and DNA protection.

Hyper-recombination in ribosomal DNA is driven by long-range resection-independent RAD51 accumulation.

Asymptomatic Bloom syndrome diagnosed by chance in a patient with breast cancer.

TRF2-RAP1 represses RAD51-dependent homology-directed telomere repair by promoting BLM-mediated D-loop unwinding and inhibiting BLM-DNA2-dependent 5'-end resection.

Increased frequency of clonal hematopoiesis of indeterminate potential in Bloom syndrome probands and carriers.

ATM, BLM, and CDH1 gene co-mutations in a high-grade endometrial stromal sarcoma patient with multiple abdominal cavity metastases: a case report and literature review.

Rare case of myelodysplastic syndrome with excess blasts 2 developing after adjuvant chemoradiotherapy for triple-negative breast cancer in a patient with Bloom syndrome.

James German and the Quest to Understand Human RECQ Helicase Deficiencies.

Characterization and regulation of cell cycle-independent noncanonical gene targeting.

RecQ helicase expression in patients with telomeropathies.

YY1 is involved in homologous recombination inhibition at guanine quadruplex sites in human cells.

Suppressors of Blm-deficiency identify three novel proteins that facilitate DNA repair in Ustilago maydis.

Bloom Syndrome Complicated by Low-Grade Lymphoma and Non-small Cell Lung Cancer: A Case Report.

Bloom syndrome DNA helicase mitigates mismatch repair-dependent apoptosis.

Circ_0001671 regulates prostate cancer progression through miR-27b-3p/BLM axis.

Mutations in TOP3A Cause a Bloom Syndrome-like Disorder.

BLM helicase unwinds lagging strand substrates to assemble the ALT telomere damage response.

A case of Bloom syndrome manifesting with therapy-related myelodysplastic syndromes harboring a novel BLM gene variant.

Genetic testing for hereditary cancer syndromes in Tunisian patients: Impact on health system.

TFIP11 promotes replication fork reversal to preserve genome stability.

BLM and BRCA1-BARD1 coordinate complementary mechanisms of joint DNA molecule resolution.

Design and synthesis of quinazolin-4-one derivatives as potential anticancer agents and investigation of their interaction with RecQ helicases.

Prenatal Testing for Variants in Genes Associated with Hereditary Cancer Risk: Laboratory Experience and Considerations.

BLM mutation is associated with increased tumor mutation burden and improved survival after immunotherapy across multiple cancers.

Coexistence of Bloom Syndrome and Kostmann Disease and a Novel Mutation.

RMI1 facilitates repair of ionizing radiation-induced DNA damage and maintenance of genomic stability.

Bisbenzylisoquinoline alkaloid fangchinoline derivative HY-2 inhibits breast cancer cells by suppressing BLM DNA helicase.

Ischemic Stroke with Positive Antiphospholipid Antibodies in Bloom Syndrome: A Case Report.

Congenital Telangiectatic Erythema: Scoping Review.

A CK2 and SUMO-dependent, PML NB-involved regulatory mechanism controlling BLM ubiquitination and G-quadruplex resolution.

Hematopoietic cell transplantation for hematological malignancies in Bloom syndrome.

Bloom syndrome patients and mice display accelerated epigenetic aging.

BLM helicase protein negatively regulates stress granule formation through unwinding RNA G-quadruplex structures.

PARP1 negatively regulates transcription of BLM through its interaction with HSP90AB1 in prostate cancer.

BLM overexpression as a predictive biomarker for CHK1 inhibitor response in PARP inhibitor-resistant BRCA-mutant ovarian cancer.

Understanding G-Quadruplex Biology and Stability Using Single-Molecule Techniques.

Biochemical properties of naturally occurring human bloom helicase variants.

Photoelectrochemical polarity-switching-mode and split-type biosensor based on SQ-COFs/BiOBr heterostructure for the detection of uracil-DNA glycosylase.

A unique case of Bloom syndrome with a combination of genetic hits: A lesson from trio‑based exome sequencing: A case report.

Pathological variants in TOP3A cause distinct disorders of mitochondrial and nuclear genome stability.

Infections in DNA Repair Defects.

KNO1-mediated autophagic degradation of the Bloom syndrome complex component RMI1 promotes homologous recombination.

RecQ dysfunction contributes to social and depressive-like behavior and affects aldolase activity in mice.

Bloom syndrome: an oral potentially malignant disorders aiding in malignancy vigour.

Bloom syndrome in children: unusual case of early onset lung damage.

Protocol for a high titer of BaEV-Rless pseudotyped lentiviral vector: Focus on syncytium formation and detachment.

Intellectual disability and abnormal cortical neuron phenotypes in patients with Bloom syndrome.

Germline Pathogenic Variants in Squamous Cell Carcinoma of the Head and Neck.

BLM promotes malignancy in PCa by inducing KRAS expression and RhoA suppression via its interaction with HDGF and activation of MAPK/ERK pathway.

ML216-Induced BLM Helicase Inhibition Sensitizes PCa Cells to the DNA-Crosslinking Agent Cisplatin.

The MRN complex and topoisomerase IIIa-RMI1/2 synchronize DNA resection motor proteins.

Discovery of a Novel Bloom's Syndrome Protein (BLM) Inhibitor Suppressing Growth and Metastasis of Prostate Cancer.

N6‑methyladenosine‑induced long non‑coding RNA PVT1 regulates the miR‑27b‑3p/BLM axis to promote prostate cancer progression.

Design, synthesis and evaluation of N3-substituted quinazolinone derivatives as potential Bloom's Syndrome protein (BLM) helicase inhibitor for sensitization treatment of colorectal cancer.

Involvement of a BH3-only apoptosis sensitizer gene Blm-s in hippocampus-mediated mood control.

Beta Human Papillomavirus 8 E6 Induces Micronucleus Formation and Promotes Chromothripsis.

Refractory gastroduodenal ulcers: A rare complication with Bloom syndrome.

Simultaneous Mechanical and Fluorescence Detection of Helicase-Catalyzed DNA Unwinding.

Downregulation of BLM RecQ helicase inhibits proliferation, promotes the apoptosis and enhances the sensitivity of bladder cancer cells to cisplatin.

Bloom Syndrome Helicase Compresses Single-Stranded DNA into Phase-Separated Condensates.

BLM Sumoylation Is Required for Replication Stability and Normal Fork Velocity During DNA Replication.

Novel TOP3A Variant Associated With Mitochondrial Disease: Expanding the Clinical Spectrum of Topoisomerase III Alpha-Related Diseases.

A case of Rothmund-Thomson syndrome originally thought to be a case of Bloom syndrome.

Genomic characterization of lymphomas in patients with inborn errors of immunity.

The convergence of head-on DNA unwinding forks induces helicase oligomerization and activity transition.

Identifying novel SMYD3 interactors on the trail of cancer hallmarks.

Bloom helicase mediates formation of large single-stranded DNA loops during DNA end processing.

Radiotherapy and radiosensitivity syndromes in DNA repair gene mutations.

Bloom syndrome helicase contributes to germ line development and longevity in zebrafish.

Age of first cancer diagnosis and survival in Bloom syndrome.

High Expression of Bloom Syndrome Helicase is a Key Factor for Poor Prognosis and Advanced Malignancy in Patients with Pancreatic Cancer: A Retrospective Study.

Bloom syndrome for which second chromosomal analysis led to early diagnosis.

Phenotypic spectrum of BLM- and RMI1-related Bloom syndrome.

The CDK1-TOPBP1-PLK1 axis regulates the Bloom's syndrome helicase BLM to suppress crossover recombination in somatic cells.

The toposiomerase IIIalpha-RMI1-RMI2 complex orients human Bloom's syndrome helicase for efficient disruption of D-loops.

Mechanism of Bloom syndrome complex assembly required for double Holliday junction dissolution and genome stability.

Duplex DNA and BLM regulate gate opening by the human TopoIIIα-RMI1-RMI2 complex.

Single-cell transcription profiles in Bloom syndrome patients link BLM deficiency with altered condensin complex expression signatures.

New resources for the Drosophila 4th chromosome: FRT101F enabled mitotic clones and Bloom syndrome helicase enabled meiotic recombination.

Homology-directed repair involves multiple strand invasion cycles in fission yeast.

Exonic sequencing and MLH3 gene expression analysis of breast cancer patients.

Anti-recombination function of MutSα restricts telomere extension by ALT-associated homology-directed repair.

RNF4 Regulates the BLM Helicase in Recovery From Replication Fork Collapse.

Blm helicase facilitates rapid replication of repetitive DNA sequences in early Drosophila development.

BLM helicase inhibition synergizes with PARP inhibition to improve the radiosensitivity of olaparib resistant non-small cell lung cancer cells by inhibiting homologous recombination repair.

Bloom Helicase Along with Recombinase Rad51 Repairs the Mitochondrial Genome of the Malaria Parasite.

The coincidence of two rare diseases with opposite metabolic phenotype: a child with congenital hyperinsulinism and Bloom syndrome.

Replication protein A large subunit (RPA1a) limits chiasma formation during rice meiosis.

USP37 regulates DNA damage response through stabilizing and deubiquitinating BLM.

Two novel variants and follow-up findings in four children with Bloom syndrome from two families.

Human RecQL4 as a Novel Molecular Target for Cancer Therapy.

Spectrum of hematological malignancies, clonal evolution and outcomes in 144 Mayo Clinic patients with germline predisposition syndromes.

Type I Interferon Induction in Cutaneous DNA Damage Syndromes.

A novel cell-cycle-regulated interaction of the Bloom syndrome helicase BLM with Mcm6 controls replication-linked processes.

The catalytic core of Leishmania donovani RECQ helicase unwinds a wide spectrum of DNA substrates and is stimulated by replication protein A.

Considerations for radiotherapy in Bloom Syndrome: A case series.

Distinct pathways of homologous recombination controlled by the SWS1-SWSAP1-SPIDR complex.

EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart.

Case Report: Diabetes in Chinese Bloom Syndrome.

Genetic Characterization of Short Stature Patients With Overlapping Features of Growth Hormone Insensitivity Syndromes.

Bloom syndrome in a Mexican American family with rhabdomyosarcoma: evidence of a Mexican founder mutation.

High BLM Expression Predicts Poor Clinical Outcome and Contributes to Malignant Progression in Human Cholangiocarcinoma.

Functions of BLM Helicase in Cells: Is It Acting Like a Double-Edged Sword?

Inherited skin disorders presenting with poikiloderma.

Bloom syndrome and the underlying causes of genetic instability.

Bloom helicase explicitly unwinds 3'-tailed G4DNA structure in prostate cancer cells.

Human RecQ Helicases in DNA Double-Strand Break Repair.

Super-resolution mapping of cellular double-strand break resection complexes during homologous recombination.

Improved Genome Editing through Inhibition of FANCM and Members of the BTR Dissolvase Complex.

DNA repair gene polymorphisms and chromosomal aberrations in healthy, nonsmoking population.

Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein.

Predominant cellular mitochondrial dysfunction in the TOP3A gene-caused Bloom syndrome-like disorder.

Human RecQ helicases in transcription-associated stress management: bridging the gap between DNA and RNA metabolism.

Analysis of m6A RNA Methylation-Related Genes in Liver Hepatocellular Carcinoma and Their Correlation with Survival.

The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks.

Bloom syndrome DNA helicase deficiency is associated with oxidative stress and mitochondrial network changes.

Alternative lengthening of telomeres is a self-perpetuating process in ALT-associated PML bodies.

HERC2 inactivation abrogates nucleolar localization of RecQ helicases BLM and WRN.

A Structural Guide to the Bloom Syndrome Complex.

Heterozygous germline BLM mutations increase susceptibility to asbestos and mesothelioma.

Withdrawal: Selective cleavage of BLM, the Bloom syndrome protein, during apoptotic cell death.

Multidisciplinary management of endocrinopathies and treatment-related toxicities in patients with Bloom syndrome and cancer.

Infantile fibrosarcoma with TPM3-NTRK1 fusion in a boy with Bloom syndrome.

PAR-TERRA is the main contributor to telomeric repeat-containing RNA transcripts in normal and cancer mouse cells.

Determinants of replication protein A subunit interactions revealed using a phosphomimetic peptide.

Bloom's syndrome with growth hormone deficiency: a rare association.

Missing heritability in Bloom syndrome: First report of a deep intronic variant leading to pseudo-exon activation in the BLM gene.

The value of whole exome sequencing for genetic diagnosis in a patient with Bloom syndrome.

Break-induced replication promotes fragile telomere formation.

Quantitative and real-time measurement of helicase-mediated intra-stranded G4 unfolding in bulk fluorescence stopped-flow assays.

Interhomolog Homologous Recombination in Mouse Embryonic Stem Cells.

Pathophysiology of premature aging characteristics in Mendelian progeroid disorders.

RECQ DNA Helicases and Osteosarcoma.

The identification of six risk genes for ovarian cancer platinum response based on global network algorithm and verification analysis.

Molecular Biology of Osteosarcoma.

Investigating the pathogenic SNPs in BLM helicase and their biological consequences by computational approach.

Mutations in conserved functional domains of human RecQ helicases are associated with diseases and cancer: A review.

Design, Synthesis, and Evaluation of New Quinazolinone Derivatives that Inhibit Bloom Syndrome Protein (BLM) Helicase, Trigger DNA Damage at the Telomere Region, and Synergize with PARP Inhibitors.

Vpu modulates DNA repair to suppress innate sensing and hyper-integration of HIV-1.

Diagnosis of Bloom Syndrome in a Patient with Short Stature, Recurrence of Malignant Lymphoma, and Consanguineous Origin.

[Challenges of screening germline predispositions in children].

[Analysis of clinical features and genetic variants in an infant with Bloom syndrome].

Recognition and Unfolding of c-MYC and Telomeric G-Quadruplex DNAs by the RecQ C-Terminal Domain of Human Bloom Syndrome Helicase.

Hereditary Predisposition to Hematopoietic Neoplasms: When Bloodline Matters for Blood Cancers.

Specificity of end resection pathways for double-strand break regions containing ribonucleotides and base lesions.

Complete remission of refractory juvenile acute myeloid leukaemia with RUNX1-PRDM16 in Bloom syndrome after haematopoietic stem cell transplantation.

Malar rash in a young child with neurodevelopmental delay: a quiz.

Recent advances in Wilms' tumor predisposition.

Human pluripotent stem cell-based models suggest preadipocyte senescence as a possible cause of metabolic complications of Werner and Bloom Syndromes.

A distinct role for recombination repair factors in an early cellular response to transcription-replication conflicts.

Identification of cancer stem cell-related biomarkers in lung adenocarcinoma by stemness index and weighted correlation network analysis.