Síndrome corticobasal

UPenn Observational Research Repository on Neurodegenerative Disease

NCT04715399

The CurePSP Genetics Program

NCT06647641

Scrambler Therapy for Corticobasal Syndrome-Associated Pain

NCT05653778

Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative Modeling

NCT06529744

STELLA-FTD: Examination of a Behavior Change Intervention for FTD Family Care Partners

NCT06613204

NCT04715399 · UPenn Observational Research Repository on Neurodegenerative…Recrutando

🟢 Recrutando agora

8 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

NCT06647641 · The CurePSP Genetics ProgramRecrutando

NCT05653778 · Scrambler Therapy for Corticobasal Syndrome-Associated PainRecrutando

NCT06529744 · Improving Prognostic Confidence in Neurodegenerative Disease…Recrutando

NCT06613204 · STELLA-FTD: Examination of a Behavior Change Intervention fo…Recrutando

NCT07000851 · Imaging Studies in Corticobasal SyndromeRecrutando

NCT02964637 · Diagnosing Frontotemporal Lobar DegenerationRecrutando

NCT06162013 · The NADAPT Study: a Randomized Double-blind Trial of NAD Rep…Recrutando

PHASE2

Outros ensaios clínicos

61 ensaios clínicos encontrados, 12 ativos.

Distribuição por fase

NCT05983588 · PROFIL Study to Investigate the Effect of GPB on NfL Levels …Ativo

PHASE2

NCT05073471 · Music and Brain Stimulation for Upper Extremity Performance …Ativo

NCT06870838 · Neuroinflammation in FTLDAtivo

NCT07333898 · Digital Measurements of Motor and Voice Functions in FTDEm breve

NCT06224920 · Activity of Cerebral Networks, Amyloid and Microglia in Agin…Concluído

NCT02966145 · 4-Repeat Tauopathy Neuroimaging Initiative - Cycle 2Concluído

NCT03552484 · In-Home Care for Patients With PSP and Related DisordersConcluído

NCT04734379 · Rho Kinase (ROCK) Inhibitor in Tauopathies - 1UNKNOWN

PHASE2

NCT02365922 · Advancing Research and Treatment for Frontotemporal Lobar De…Concluído

Ver todos no ClinicalTrials.gov

🧪 Está conduzindo uma pesquisa?

Divulgue para pacientes e familiares que acompanham esta doença.

Divulgar pesquisa →

Publicações mais relevantes

Timeline de publicações

758 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 758

#1

Incidence and Survival Rates of Frontotemporal Lobar Degeneration: Population-Based Registry Study.

Neurology2026 Mar 24

Frontotemporal lobar degeneration (FTLD) can present as a behavioral or language variant (bvFTLD or a primary progressive aphasia [PPA], or as a syndrome with parkinsonism, such as corticobasal syndrome [CBS] or progressive supranuclear palsy [PSP]). The incidence of FTLD varies in epidemiologic studies, reaching 3 per 100,000 person-years. Only few data exist regarding survival times. We evaluated incidence and survival rates in a population-based registry with high coverage in Southern Germany. The epidemiologic ALS-FTLD registry Swabia covers a population of 8.4 million inhabitants in south-west Germany. Raw and age-standardized incidence rates, as well as incidence rate ratios (IRR) with 95% CIs were calculated. Median survival time was estimated for different FTLD variants using the Kaplan-Meier method. Between 2015 and 2022, 515 patients with FTLD (mean age at diagnosis 68.0 ± 9.5 years, 59.8% men) were registered. The median diagnostic delay was 24.8 months. The most common variant was bvFTLD (n = 185, 35.9%; 66.5% men), followed by PPA (n = 147, 28.5%; 51.0% men), PSP (n = 133, 25.8%; 62.9% men), and CBS (n = 22, 4.3%; 50% men). The overall FTLD incidence was 0.77 (95% CI 0.71-0.84), and the age-standardized incidence was 0.76 (95% CI 0.69-0.82) per 100.000 person-years. The age-standardized incidence was higher in men than in women, with an IRR of 1.73 (95% CI 1.44-2.00). In men, incidence increased from the age 50 years, primarily due to bvFTD, whereas in women this rise was primarily due to PSP. The median survival (N = 392) from diagnosis was 53.6 months (95% CI 50.9-62.0) overall, 73.1 months (95% CI 63.6-82.8) for patients with PPA, 42.8 months (95% CI 35.1-64.3) for patients with bvFTD, and 49.5 months (95% CI 39.2-53.7) for patients with PPS/CBS. We observed a raw incidence rate of 0.77, thus considerably lower than in most previous reports. Incidence was substantially higher in men than in women. The prognosis from the time of diagnosis depended highly on the specific FTLD subtype. Our data are based on the large sample size and high capture rate of a central European population-based registry.

#2

Multi-model Diffusion MRI Signatures in Atypical Parkinsonian Disorders.

medRxiv : the preprint server for health sciences2026 Feb 05

Distinguishing atypical parkinsonian disorders (APS) from Parkinson's disease (PD) remains challenging due to overlapping clinical features, yet accurate differentiation is critical for prognosis and treatment. Here, we employed multi-model diffusion MRI (dMRI) analysis to characterize microstructural alterations across corticobasal syndrome (CBS), progressive supranuclear palsy-Richardson syndrome (PSP-RS) and PD, with the aim of identifying which dMRI model provides optimum differentiation. We analyzed 25 CBS, 42 PSP-RS, and 21 PD participants compared to 35 age and sex-matched controls. Using a clinically feasible 3-shell high angular resolution diffusion imaging (HARDI) protocol, we applied 11 metrics from five complementary dMRI models-diffusion tensor imaging (DTI), free-water-eliminated model of DTI (FWE), neurite orientation dispersion and density imaging (NODDI), tissue-weighted NODDI, and Fixel Density (FD) in fixel-based analysis (FBA) -to comprehensively assess regional white and gray matter integrity. Group differentiation was assessed using Cohen's d effect sizes and spearman correlations were assessed between dMRI metrics and clinical scales. Distinct microstructural signatures were observed across disorders and the sensitivity of the dMRI models differed. In group contrasts, DTI and NODDI-derived metrics consistently captured the strongest effects in midbrain and peduncular pathways for PSP-RS, whereas precentral and corticospinal alterations in CBS were most prominent using NODDI and FBA measures. Free-water-corrected metrics showed attenuated group differences. Across clinical-diffusion analyses, NODDI metrics exhibited the most robust associations with disease severity, while DTI and FWE measures detected more limited, regionally constrained effects. Together, these findings highlight complementary yet distinct sensitivities of tensor, free-water, multi-compartment, and fixel-based models to APS-related neurodegeneration.

#3

Interpeduncular Angle: A Possible Marker to Differentiate Atypical Parkinsonism from Idiopathic Parkinson's Disease.

Annals of Indian Academy of Neurology2026 Jan 01

Atypical parkinsonian disorders (APD), such as progressive supranuclear palsy (PSP), multiple system atrophy (MSA), corticobasal syndrome (CBS), and Lewy body dementia (LBD) are frequently misdiagnosed, commonly as Parkinson's disease (PD). The study aims to assess the utility of the interpeduncular angle (IPA) in distinguishing APD from PD across age ranges. This retrospective study was conducted with 225 patients (75 with APD, 75 with PD, and 75 healthy controls). Patients were categorized into three age groups: (51-60, 61-70, and 71-80 years). Two independent raters measured the IPA from T1-weighted axial brain magnetic resonance images (MRIs) at a level below the mammillary bodies using standardized measurement techniques. The APD group included 51 (68%) with PSP, 16 (21.33%) with MSA, 5 (6.67%) with LBD, and 3 (4%) with CBS. Bland-Altman analysis for angle measurement suggested good to excellent agreement between raters ( P < 0.001). IPA measurements among the different diagnostic groups showed that PSP was higher than controls ( P < 0.001) and PD ( P < 0.001), and MSA was higher than controls ( P < 0.001) and PD ( P = 0.003). There was no significant association between IPA and age in the APD phenotypes. With increasing age, the significance between APD and IPD groups decreased ( P < 0.001 in 51-60 years to P = 0.686 in 71-80 years). Receiver Operating Characteristic (ROC) analysis revealed increasing IPA thresholds for PSP versus PD (67.66° in 51-60 years to 75.71° in 71-80 years). IPA is not reliable in differentiating APD, particularly PSP and MSA, from PD and controls.

#4

Utility of Locus Coeruleus Signal Intensity on High-resolution T1-weighted MR Imaging with Magnetization Transfer for Differentiating Parkinson's Disease from Atypical Parkinsonism.

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine2026 Feb 26

This study aimed to evaluate the diagnostic utility of locus coeruleus (LC) signal intensity on high-resolution T1-weighted imaging with magnetization transfer (T1WI with MT) for distinguishing Parkinson's disease (PD) from a broad range of atypical parkinsonism (AP) subtypes, including early-stage cases. We retrospectively analyzed T1WI with MT data from 214 participants, including patients with PD (n = 125), corticobasal syndrome (CBS, n = 12), multiple system atrophy (MSA, n = 16), progressive supranuclear palsy (PSP, n = 19), essential tremor (n = 17), vascular parkinsonism (n = 4), drug-induced parkinsonism (DIP, n = 7), and healthy subjects (HS, n = 14). Circular ROIs were placed on the LC and substantia nigra pars compacta to calculate contrast ratios (CRs). Conventional MRI findings of AP, focusing on characteristic regional atrophy patterns, were also evaluated. Diagnostic performance was assessed using receiver operating characteristic (ROC) analysis. A subanalysis was performed for early-stage cases (within 2 years of onset). Three independent neuroradiologists evaluated T1WI with MT, and interobserver agreement was assessed using intraclass correlation coefficients (ICC). The LC-CR was significantly lower in PD than in HS (P < 0.01) and all AP subtypes except DIP (P = 0.37). ROC analysis revealed that LC-CR had the highest diagnostic accuracy for differentiating PD from AP (area under the curve [AUC] = 0.83, sensitivity = 67%, specificity = 90%). In early-stage cases, LC-CR maintained high specificity (98%) with an AUC of 0.80. The diagnostic utility of LC-CR was comparable or superior to conventional MRI findings in distinguishing PD from CBS, MSA, and PSP. Interobserver agreement for LC-CR measurements was good, with an ICC of 0.87 (95% confidence interval: 0.85-0.89). LC-CR measured on T1WI with MT serves as a reliable imaging biomarker for differentiating PD from various forms of AP, even in early disease stages.

#5

[Basal ganglia and movement disorders : Part 1: the parkinsonian spectrum-Neuroradiological patterns and diagnostic considerations].

Radiologie (Heidelberg, Germany)2026 Mar 16

Movement disorders are a frequent yet diagnostically unspecific reason for referral in routine neuroradiological practice. Hypokinetic syndromes with parkinsonism in particular regularly raise the question of an underlying neurodegenerative disorder, while requiring careful differentiation from atypical parkinsonian syndromes and secondary causes. This first part of the review focuses on the neuroradiological assessment of degenerative movement disorders, with an emphasis on the parkinsonian spectrum. It is grounded in the functional anatomy of the basal ganglia and their integration into motor networks. Building on this framework, a practice-oriented diagnostic approach is presented in which clinical phenotypes, temporal evolution, and accompanying symptoms serve as guiding criteria for targeted image interpretation. The article addresses idiopathic Parkinson's disease as well as atypical parkinsonian syndromes, in particular progressive supranuclear palsy, multiple system atrophy, and corticobasal syndrome. Typical and atypical magnetic resonance imaging (MRI) patterns, established morphometric markers, and the diagnostic limitations of visual signs such as the swallow-tail sign are critically discussed. In addition, neuromelanin-sensitive MRI, susceptibility-based techniques, and artificial intelligence (AI)-supported approaches are reviewed, with explicit consideration of their current limitations. The aim of this contribution is to enable a structured and clinically robust neuroradiological assessment of parkinsonism and to use imaging in a targeted manner for differential diagnosis and guidance of further diagnostic work-up. Bewegungsstörungen gehören zu den häufigen, zugleich aber unspezifischen Zuweisungsgründen in der neuroradiologischen Routine. Gerade hypokinetische Syndrome mit Parkinsonismus werfen regelmäßig die Frage nach einer zugrunde liegenden neurodegenerativen Erkrankung auf, erfordern jedoch eine sorgfältige Abgrenzung gegenüber atypischen Parkinson-Syndromen und sekundären Ursachen. Der vorliegende erste Teil der Übersichtsarbeit widmet sich der neuroradiologischen Einordnung degenerativer Bewegungsstörungen mit Schwerpunkt auf dem Parkinson-Spektrum. Ausgangspunkt ist die funktionelle Anatomie der Basalganglien und ihre Einbindung in motorische Netzwerke. Darauf aufbauend wird ein praxisorientierter diagnostischer Ansatz vorgestellt, bei dem klinische Phänotypen, zeitlicher Verlauf und Begleitsymptome als leitende Kriterien für die gezielte Bildanalyse dienen. Im Fokus stehen das idiopathische Parkinson-Syndrom sowie atypische Parkinson-Syndrome, insbesondere die progressive supranukleäre Blickparese, die Multisystematrophie und das kortikobasale Syndrom. Typische und atypische Muster in der Magnetresonanztomographie (MRT), etablierte morphometrische Marker sowie die diagnostischen Grenzen visueller Zeichen wie des Swallow-tail-Zeichens werden kritisch eingeordnet. Ergänzend werden Neuromelanin-sensitive MRT, suszeptibilitätsbasierte Verfahren und KI-gestützte Ansätze inklusive ihrer Limitationen diskutiert. Ziel dieses Beitrags ist es, eine strukturierte und klinisch belastbare neuroradiologische Befundung bei Parkinsonismus zu ermöglichen und die Bildgebung gezielt zur Differenzialdiagnostik und zur Steuerung weiterführender Untersuchungen einzusetzen.

Publicações recentes

Biomarker-Based Corticobasal Syndrome Classification: The Added Value of Deep Phenotyping and Population Diversity.

Mov Disord2026 Apr 14

Exploring the phenotypic spectrum of frontotemporal lobar degeneration.

Neurol Neurochir Pol2026 Apr 14

Data-driven modelling of tau pathology reveals distinct progressive supranuclear palsy subtypes.

Brain2026 Apr 13

Additive effect of patient anosognosia and theory of mind deficit on dementia caregiver distress.

Front Neurol2026

Ver todas no PubMed

📚 EuropePMC404 artigos no totalmostrando 193

Radiologie (Heidelberg, Germany)

[Basal ganglia and movement disorders : Part 1: the parkinsonian spectrum-Neuroradiological patterns and diagnostic considerations].

Improving access to care through transportation and internet use for patients with atypical parkinsonism: A pilot study.

Incidence and Survival Rates of Frontotemporal Lobar Degeneration: Population-Based Registry Study.

medRxiv : the preprint server for health sciences

Multi-model Diffusion MRI Signatures in Atypical Parkinsonian Disorders.

Real-world evaluation of Armstrong's criteria in corticobasal degeneration: Phenotypic overlap and diagnostic challenges.

Automated differentiation of parkinsonian disorders: an ROI-based analysis of subcortical shape and cortical surface features.

Cognitive neurodynamics

The journal of prevention of Alzheimer's disease

Potential role of MRI to optimize clinical trial design for progressive supranuclear palsy and corticobasal degeneration.

Movement disorders : official journal of the Movement Disorder Society

Localized Iron Deposition and Shape Changes of Cerebellar Dentate in Progressive Supranuclear Palsy Clinical Variants.

Voice and Speech in Atypical Parkinsonian Disorders.

CORTICOBASAL SYNDROME PRESENTING AS A PROGRESSIVE HEMIPARETIC SYNDROME: A CASE REPORT.

Georgian medical news

Praja1 E3 ubiquitin ligase and the role it plays in neurodegeneration.

The FEBS journal

White matter hyperintensities in the deep cerebral venous territory differ between subcortical and cortical 4-repeat tauopathies.

Amyotrophic lateral sclerosis & frontotemporal degeneration

MAPT p.V363I mutation in a patient with presenile dementia and late amyotrophic lateral sclerosis.

The Paper-Toss Test: enhancing bedside recognition of corticobasal syndrome.

BMJ supportive & palliative care

Progressive supranuclear palsy and corticobasal syndrome: cross-sectional study of palliative care needs.

Functional network collapse in neurodegenerative disease.

Nature communications

Annals of Indian Academy of Neurology

Interpeduncular Angle: A Possible Marker to Differentiate Atypical Parkinsonism from Idiopathic Parkinson's Disease.

The genetic landscape of frontotemporal lobar degeneration: investigation of a diagnostic cohort of 2747 probands.

Diagnostics (Basel, Switzerland)

Potential Role of Transferrin and Vascular Cell Adhesion Molecule 1 in Differential Diagnosis Among Patients with Tauopathic Atypical Parkinsonian Syndromes.

Chorea and Levodopa-Induced Dyskinesia in Corticobasal Syndrome: Two Case Reports with Pathological Insights and Literature Review.

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine

Utility of Locus Coeruleus Signal Intensity on High-resolution T1-weighted MR Imaging with Magnetization Transfer for Differentiating Parkinson's Disease from Atypical Parkinsonism.

The Effects of Multimodal Exercise on Sleep Quality and Architecture, Motor Function, Cognition, Fatigue, and Systemic Inflammation in Corticobasal Syndrome: A Case Report.

Physical therapy

Alzheimer's & dementia : the journal of the Alzheimer's Association

Discordant cerebrospinal fluid and positron emission tomography amyloid biomarkers in an APP mutation carrier presenting corticobasal syndrome.

Early subtypes and progressions of progressive supranuclear palsy: a data-driven brain bank study.

Expanding the genetic spectrum of corticobasal syndrome: novel CCNF p.M394L variant from a South Asian cohort.

Neurocase

Orphanet journal of rare diseases

Unraveling the mystery of alien hand syndrome: when your hand has a mind of its own.

Movement disorders : official journal of the Movement Disorder Society

A Biomarker-Based Classification of Corticobasal Syndrome.

Alzheimer's & dementia (Amsterdam, Netherlands)

A Bayesian analysis of diagnostic timelines across Alzheimer's disease, frontotemporal dementia, and other neurodegenerative conditions.

Tracking prodromal Parkinson's disease: a five-year follow-up of the PARCAS cohort.

Neuroanatomical normative modelling in frontotemporal lobar degeneration: higher heterogeneity in the behavioural variant.

Journal of neural transmission (Vienna, Austria : 1996)

Elevated levels of cerebrospinal fluid soluble triggering receptor expressed on myeloid cells 2 in multiple system atrophy: a marker of disease-associated microglial activation.

α-Synuclein seed amplification assay positivity beyond synucleinopathies.

EBioMedicine

Journal of movement disorders

Possible Contribution of Parietal Lobe Dysfunction to Hand-Foot Synkinesis in Corticobasal Syndrome: A Case Report.

Asymmetric Applause Sign in Corticobasal Syndrome: A Case of Clonic Motor Perseveration.

Acoustic Analysis of Apraxia of Speech in a Japanese Patient With Nonfluent/Agrammatic Variant Primary Progressive Aphasia: A Case Study.

Cureus

International journal of molecular sciences

A Review of FDG-PET in Progressive Supranuclear Palsy and Corticobasal Syndrome.

Incidence and Prevalence of Frontotemporal Dementia: A Systematic Review and Meta-Analysis.

JAMA neurology

Pain medicine case reports

Scrambler Therapy for the Treatment of Chronic Neuropathic Pain in Atypical Parkinsonian Disorders: A Case Series.

Progressive Supranuclear Palsy-A Global Review.

Detecting amyloid and tau pathology in Parkinson's disease, 4R-tauopathies and control subjects with plasma pTau217.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Alzheimer's disease traits in Parkinson's disease without α-synuclein seeding.

Movement disorders : official journal of the Movement Disorder Society

Prevalence of NOTCH2NLC and FMR1 Repeat Expansions in Atypical Parkinsonism Compared to Asymptomatic Elderly Individuals.

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

[Diagnosis of Alzheimer's disease using biological markers in corticobasal syndrome].

Serious Illness Conversation in the Care of Atypical Parkinsonian Disorders: A Practical Guide for Neurology Clinicians.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

Cortical hyperexcitability in corticobasal syndrome as revealed by giant somatosensory evoked potentials.

Journal of the International Neuropsychological Society : JINS

Differences in neuropsychological performance across clinical variants of progressive supranuclear palsy.

Connectivity as a universal predictor of tau progression in atypical Alzheimer's disease.

Continuum (Minneapolis, Minn.)

Progressive Supranuclear Palsy and Corticobasal Syndrome.

Differences in gait apraxia due to reduced regional cerebral blood flow in the supplementary motor area in corticobasal syndrome: a report of two cases.

BMC neurology

Cognitive Decline in Parkinsonism: From Clinical Phenotypes to the Genetic Background.

Biomedicines

Diagnostic utility of tectal plate measures in clinical variants of progressive supranuclear palsy.

Journal of the neurological sciences

Delayed progressive apraxia of speech: A novel clinical entity distinct from primary progressive aphasia - A descriptive case series.

Acta neuropathologica communications

Frontotemporal Lobar degeneration with TDP-43 presenting as progressive supranuclear palsy syndrome.

Accelerated Intermittent Theta Burst Stimulation Combined with Balance Training Improves Balance in an Individual with Corticobasal Syndrome.

Progression and natural history of Atypical Parkinsonism (ATPARK): Protocol for a longitudinal follow-up study from an underrepresented population.

PloS one

PCN reports : psychiatry and clinical neurosciences

Neurological soft signs in neurodegenerative dementias: Results of the DemeNSS study.

Clinical neurology and neurosurgery

Pick's disease presenting as progressive apraxia of speech: Atypical clinical and neuroimaging features in three autopsy-confirmed cases.

Evaluation of disproportionately enlarged subarachnoid-space hydrocephalus in progressive supranuclear palsy.

Prospective longitudinal cohort of Argentinean patients with progressive supranuclear palsy and corticobasal syndrome: A platform for epidemiological and translational research.

Journal of neural transmission (Vienna, Austria : 1996)

A narrative review of serum biomarkers in progressive supranuclear palsy, corticobasal syndrome, and related disorders.

Cognitive Performance in Parkinson's Spectrum Disorders: a comparative study of patients with Parkinson's Disease, Parkinson's Disease Dementia, Dementia With Lewy Bodies, Progressive Supranuclear Palsy, and Corticobasal Syndrome.

Assessment

Journal of movement disorders

Atypical Imaging Findings in Corticobasal Syndrome: A Case Report.

Movement disorders : official journal of the Movement Disorder Society

Neurophysiology of Atypical Parkinsonian Syndromes: A Study Group Position Paper.

Computer Vision Technologies in Movement Disorders: A Systematic Review.

European archives of psychiatry and clinical neuroscience

Plasma biomarkers of amyloid, tau & neuroinflammation in Alzheimer's disease and corticobasal syndrome.

Medicina (Kaunas, Lithuania)

Differentiating Progressive Supranuclear Palsy and Corticobasal Syndrome: Insights from Cerebrospinal Fluid Biomarkers-A Narrative Review.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

[18F]Florzolotau PET for the Differential Diagnosis of Parkinsonism in Patients with Suspected 4-Repeat Tauopathies.

Cognitive and neuropsychiatric profiles distinguish atypical parkinsonian syndromes.

Cerebrospinal fluid and blood neurofilament light chain in Parkinson's disease and atypical parkinsonian syndromes: a systematic review and Bayesian network meta-analysis.

Neurofilament Light Chain in Cerebrospinal Fluid and Blood in Multiple System Atrophy: A Systematic Review and Meta-Analysis.

Brain sciences

Case report: Behavioral variant FTD confounding a language variant FTD in a case of PSP-CBS.

Frontiers in dementia

Analysis of C9orf72 repeat length in progressive supranuclear palsy, corticobasal syndrome, corticobasal degeneration, and atypical parkinsonism.

Neuropathology and applied neurobiology

Identical Seeding Characteristics and Cryo-EM Filament Structures in FTLD-Synuclein and Typical Multiple System Atrophy.

Unveiling the enigmatic: Primary progressive apraxia of speech - A case report.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Relationships between hypometabolism and both β-amyloid and tau PET in corticobasal syndrome.

Molecular neurodegeneration

Comprehensive cross-sectional and longitudinal comparisons of plasma glial fibrillary acidic protein and neurofilament light across FTD spectrum disorders.

Distinct spatiotemporal atrophy patterns in corticobasal syndrome are associated with different underlying pathologies.

Journal of Alzheimer's disease reports

A progranulin gene deletion in frontotemporal lobar degeneration with corticobasal syndrome in a TREDEM case report.

Journal of Parkinson's disease

Subcortical tau burden correlates with regional brain atrophy and plasma markers in four-repeat tauopathy parkinsonism.

Journal of Alzheimer's disease : JAD

Autopsy-proven patient with corticobasal degeneration presenting with visuo-constructive disorders as initial symptoms: How advanced MRI sequences can help clinical practice.

Journal of Alzheimer's disease : JAD

Overlap in the diagnostic criteria of frontotemporal dementia syndromes with parkinsonism.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Predicting survival rate by plasma biomarkers and clinical variables in syndromes associated with frontotemporal lobar degeneration.

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

[The experience of diagnosing Alzheimer's disease based on the study of cerebrospinal fluid biomarkers].

Atypical Alzheimer's dementia: Addressing the subtypes, epidemiology, atypical presentations, diagnostic biomarkers, and treatment updates.

Disease-a-month : DM

Current treatment options in neurology

Diagnosis and Management of Progressive Corticobasal Syndrome.

Cognitive impairment in PSP compared with PD: assessment by clinical subtype and longitudinal change.

BMJ neurology open

Frequency of anti-IgLON5 disease in patients with a typical clinical presentation of progressive supranuclear palsy/corticobasal syndrome.

The Journal of neuropsychiatry and clinical neurosciences

L266V MAPT Gene Mutation Associated With Frontotemporal Dementia, Progressive Supranuclear Palsy, and Corticobasal Syndrome.

Altered cortical network dynamics during observing and preparing action in patients with corticobasal syndrome.

Neurobiology of disease

Addressing inter individual variability in CSF levels of brain derived proteins across neurodegenerative diseases.

Scientific reports

Two novel variants in GRN: the relevance of CNV analysis and genetic screening in FTLD patients with a negative family history.

Lexical markers of disordered speech in primary progressive aphasia and 'Parkinson-plus' disorders.

Corticobasal degeneration: An update.

Ideggyogyaszati szemle

Transdiagnostic Network Localization of Social, Language, and Motor Symptoms in Patients With Frontotemporal Lobar Degeneration.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Caregiver perspectives enable accurate diagnosis of neurodegenerative disease.

Journal of geriatric psychiatry and neurology

An SBM and TBSS Analysis in Early-stage Patients With Alzheimer's Disease, Lewy Body Dementias, and Corticobasal Syndrome.

Japanese longitudinal biomarker study in progressive supranuclear palsy and corticobasal degeneration: Clinical features of the first registered patients and short-term follow-up analysis.

Peripheral innate immunophenotype in neurodegenerative disease: blood-based profiles and links to survival.

Molecular psychiatry

The possible connection between neutrophil-to-high-density lipoprotein ratio and cerebral perfusion in clinically established corticobasal syndrome: a pilot study.

medRxiv : the preprint server for health sciences

MRI-Based Multi-Class Relevance Vector Machine Classification of Neurodegenerative Diseases.

Journal of clinical medicine

Asymmetry in Atypical Parkinsonian Syndromes-A Review.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

Swiss cheese brain presenting as corticobasal syndrome.

Neurology. Clinical practice

Corticobasal Syndrome: Are There Central or Peripheral Triggers?

Neurology. Clinical practice

Frontotemporal Dementia Differential Diagnosis in Clinical Practice: A Single-Center Retrospective Review of Frontal Behavioral Referrals.

Apraxia phenotypes and frontotemporal lobar degeneration.

Alzheimer's & dementia : the journal of the Alzheimer's Association

A framework for translating tauopathy therapeutics: Drug discovery to clinical trials.

Current medical research and opinion

A case of corticobasal syndrome possibly associated with anti-Yo antibodies.

Movement disorders : official journal of the Movement Disorder Society

Evaluation of Cerebrospinal Fluid α-Synuclein Seed Amplification Assay in Progressive Supranuclear Palsy and Corticobasal Syndrome.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Combining cerebrospinal fluid and PI-2620 tau-PET for biomarker-based stratification of Alzheimer's disease and 4R-tauopathies.

Journal of the neurological sciences

Clinical characteristics of Japanese patients with corticobasal degeneration.

Predictors of Care Home Admission and Survival Rate in Patients With Syndromes Associated With Frontotemporal Lobar Degeneration in Europe.

CSF α-Synuclein Seed Amplification Assay in Patients With Atypical Parkinsonian Disorders.

Cerebrospinal Fluid Total and Phosphorylated Tau Protein in Behavioral Variant Frontotemporal Dementia, Progressive Supranuclear Palsy, Corticobasal Syndrome and Non-Fluent Agrammatic Primary Progressive Aphasia: A Systematic Review and Meta-Analysis.

Biomedicines

Neurology. Clinical practice

A General Neurologist's Practical Diagnostic Algorithm for Atypical Parkinsonian Disorders: A Consensus Statement.

Determinants of care partner burden in atypical Parkinsonian syndromes: A retrospective, multi-center analysis.

Frontiers in human neuroscience

Unilateral tactile agnosia as an onset symptom of corticobasal syndrome.

Conventional magnetic resonance imaging key features for distinguishing pathologically confirmed corticobasal degeneration from its mimics: a retrospective analysis of the J-VAC study.

Neuroradiology

Brain pathology (Zurich, Switzerland)

Upper motor neuron-predominant motor neuron disease presenting as atypical parkinsonism: A clinicopathological study.

Journal of extracellular biology

Extracellular vesicles from bodily fluids for the accurate diagnosis of Parkinson's disease and related disorders: A systematic review and diagnostic meta-analysis.

Dementia & neuropsychologia

Phenotypic and Positron Emission Tomography with [18F]fluordeoxyglucose (FDG PET) differences in corticobasal syndrome: comparison of two cases.

Alzheimer's & dementia : the journal of the Alzheimer's Association

An ANXA11 P93S variant dysregulates TDP-43 and causes corticobasal syndrome.

Japanese journal of radiology

Brain perfusion SPECT in dementia: what radiologists should know.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Relationships between PET and blood plasma biomarkers in corticobasal syndrome.

Expanding the Spectrum of GBA1-Associated Neurodegenerative Diseases in an Italian Family.

Comparing classic-onset corticobasal syndrome to speech/language-onset corticobasal syndrome.

AJNR. American journal of neuroradiology

Usefulness of Olfactory Bulb Measurement in 3D-FIESTA in Differentiating Parkinson Disease from Atypical Parkinsonism.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Neurofilaments and progranulin are related to atrophy in frontotemporal lobar degeneration - A transdiagnostic study cross-validating atrophy and fluid biomarkers.

Symptomatic Unilateral Carotid Artery Disease: An Uncommon but Reversible Cause of Corticobasal Syndrome.

The neurologist

Subcortical tau is linked to hypoperfusion in connected cortical regions in 4-repeat tauopathies.

Cortex; a journal devoted to the study of the nervous system and behavior

The yes-no reversal phenomenon in patients with primary progressive apraxia of speech.

Pick's Disease Presenting as Tremulous Parkinsonism with Limited Levodopa Response-A Rare Cause of Corticobasal Syndrome.

IBRO neuroscience reports

Progressive Supranuclear Palsy Syndrome: An Overview.

Neuropathology : official journal of the Japanese Society of Neuropathology

An autopsy case of type A FTLD-TDP with a GRN mutation presenting with the logopenic variant of primary progressive aphasia at onset and with corticobasal syndrome subsequently.

Anti-IgLON5 disease as a differential diagnosis of multiple system atrophy.

Movement disorders : official journal of the Movement Disorder Society

Differential Synaptic Loss in β-Amyloid Positive Versus β-Amyloid Negative Corticobasal Syndrome.

Cerebral cortex (New York, N.Y. : 1991)

Localizing apraxia in corticobasal syndrome: a morphometric MRI study.

Detecting Abnormal Eye Movements in Patients with Neurodegenerative Diseases - Current Insights.

Eye and brain

Accuracy of routinely collected hospital administrative discharge data and death certificate ICD-10 diagnostic coding in progressive supranuclear palsy and corticobasal syndrome: a systematic review and validation study.

Clinical and Pathological Features of FTDP-17 with MAPT p.K298_H299insQ Mutation.

Progression to corticobasal syndrome: a longitudinal study of patients with nonfluent primary progressive aphasia and primary progressive apraxia of speech.

Evaluating the Effect of Alzheimer's Disease-Related Biomarker Change in Corticobasal Syndrome and Progressive Supranuclear Palsy.

Annals of neurology

Geriatrie et psychologie neuropsychiatrie du vieillissement

[Cortico-basal syndrome and cortico-basal degeneration: From the clinical diagnosis to the lesional substrate for an adapted care].

Frontiers in neuroscience

Greater white matter degeneration and lower structural connectivity in non-amnestic vs. amnestic Alzheimer's disease.

Amyloid-β prediction machine learning model using source-based morphometry across neurocognitive disorders.

Scientific reports

medRxiv : the preprint server for health sciences

Evaluation of cerebrospinal fluid alpha-synuclein seed amplification assay in PSP and CBS.

Primary Progressive Apraxia of Speech Caused by TDP-43: A Case Report.

Neurology. Genetics

SQSTM1 Pro392Leu presenting as a corticobasal syndrome with progressive nonfluent aphasia.

European journal of neurology

Frequency and outcomes of gastrostomy insertion in a longitudinal cohort study of atypical parkinsonism.

Two distinct degenerative types of nigrostriatal dopaminergic neuron in the early stage of parkinsonian disorders.

Planimetric and Volumetric Brainstem MRI Markers in Progressive Supranuclear Palsy, Multiple System Atrophy, and Corticobasal Syndrome. A Systematic Review and Meta-Analysis.

Neurology international

Total Patient Delay: A Comparison of Patient and Clinician/Health System Delays in the Diagnosis of Progressive Supranuclear Palsy and Corticobasal Syndrome.

Nucleus Basalis of Meynert Degeneration Predicts Cognitive Decline in Corticobasal Syndrome.

Biological psychiatry

Journal of movement disorders

Phenotypic Spectrum of Progressive Supranuclear Palsy: Clinical Study and Apolipoprotein E Effect.

Journal of the neurological sciences

Deep vein thrombosis and its risk factors in neurodegenerative diseases: A markedly higher incidence in Parkinson's disease.

Frontiers in bioscience (Landmark edition)

Dissecting the Clinical Heterogeneity and Genotype-Phenotype Correlations of MAPT Mutations: A Systematic Review.

Monash-Alfred protocol for assessment of atypical parkinsonian syndromes (MAP-APS).

BMJ neurology open

Journal of clinical medicine

Glucose Metabolism and Cognitive Decline in Progressive Supranuclear Palsy and Corticobasal Syndrome: A Preliminary Study.

ACS chemical neuroscience

Patients with Neurodegenerative Proteinopathies Exhibit Altered Tryptophan Metabolism in the Serum and Cerebrospinal Fluid.

Neurological research and practice

Neuropathological hints from CSF and serum biomarkers in corticobasal syndrome (CBS): a systematic review.

Association of Neurofilament Light Chain, [18F]PI-2620 Tau-PET, TSPO-PET, and Clinical Progression in Patients With β-Amyloid-Negative CBS.

Probable 4-Repeat Tauopathy Criteria Predict Brain Amyloid Negativity, Distinct Clinical Features, and FDG-PET/MRI Neurodegeneneration Patterns in Corticobasal Syndrome.

Analysis of biomarkers in speculative CNS-enriched extracellular vesicles for parkinsonian disorders: a comprehensive systematic review and diagnostic meta-analysis.

Clinical course of pathologically confirmed corticobasal degeneration and corticobasal syndrome.

Clinical course in corticobasal syndrome and corticobasal degeneration: implications for diagnosis and management.

Corticobasal syndrome mimicking Foix-Chavany-Marie syndrome with suggested 4-repeat tauopathy by tau PET.

BMC geriatrics

Annals of Indian Academy of Neurology

Neuronal Antibody-Associated Corticobasal Syndrome.

Annals of Indian Academy of Neurology

Migraine and Tension-type Headache in Parkinson's Disease and Progressive Supranuclear Palsy/Corticobasal Syndrome.

Clinical nuclear medicine

The Role of Dual-Phase 18 F-FP-CIT PET to Early Diagnosis of Corticobasal Syndrome.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

[18F]PI-2620 Binding Patterns in Patients with Suspected Alzheimer Disease and Frontotemporal Lobar Degeneration.

Amyotrophic lateral sclerosis & frontotemporal degeneration

Optineurin in patients with Amyotrophic Lateral Sclerosis associated to atypical Parkinsonism in Tunisian population.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

Left and right corticobasal syndrome: comparison of cognitive profiles between metabolic imaging - matched groups.

Lingual and Facial Myoclonus Associated with Early Corticobasal Syndrome.

CNS & neurological disorders drug targets

The Effectiveness of Transcranial Magnetic Stimulation in Treating Apraxia.

Pick's disease presenting with corticobasal syndrome: A case report and clinicopathological review.

Clinical neuropathology

Movement disorders : official journal of the Movement Disorder Society

Magnetic Susceptibility in Progressive Supranuclear Palsy Variants, Parkinson's Disease, and Corticobasal Syndrome.

Grey-matter correlates of empathy in 4-Repeat Tauopathies.

NPJ Parkinson's disease

Clinical neurology and neurosurgery

Atypical findings: Atypical parkinsonian syndromes or Atypical parkinsonian syndromes look-alikes.

Clinical nuclear medicine

Detailed Assessment of 18F-THK5351 Distribution Pattern in the Midbrain: Comparison With Progressive Supranuclear Palsy and Corticobasal Syndrome.

Journal of neurochemistry

Cerebrospinal fluid and blood serum biomarkers in neurodegenerative proteinopathies: A prospective, open, cross-correlation study.

Translational neurodegeneration

Large-scale proximity extension assay reveals CSF midkine and DOPA decarboxylase as supportive diagnostic biomarkers for Parkinson's disease.

Fiber-specific micro- and macroscopic white matter alterations in progressive supranuclear palsy and corticobasal syndrome.

NPJ Parkinson's disease

Alzheimer disease and associated disorders

A Case of Corticobasal Syndrome and Posterior Cortical Atrophy With Biomarkers of Alzheimer Disease.

Rinsho shinkeigaku = Clinical neurology

[Autoimmune encephalitis and paraneoplastic neurological syndromes presenting atypical parkinsonism: a scoping review].

Procedia computer science

A non-invasive method for prediction of neurodegenerative diseases using gait signal features.

High sensitivity of asymmetric 18F-THK5351 PET abnormality in patients with corticobasal syndrome.

Scientific reports

Association of Choroid Plexus Volume With Serum Biomarkers, Clinical Features, and Disease Severity in Patients With Frontotemporal Lobar Degeneration Spectrum.

Brain imaging and behavior

[18F]-FDopa positron emission tomography imaging in corticobasal syndrome.

Network Connectivity Alterations across the MAPT Mutation Clinical Spectrum.

Annals of neurology

Sleep & breathing = Schlaf & Atmung

Detection of episodic nocturnal hypercapnia in patients with neurodegenerative disorders.

CNS neuroscience & therapeutics

Evaluation of α-synuclein in CNS-originating extracellular vesicles for Parkinsonian disorders: A systematic review and meta-analysis.

Network neuroscience (Cambridge, Mass.)

Multiclass characterization of frontotemporal dementia variants via multimodal brain network computational inference.

Large-scale activation likelihood estimation meta-analysis of parkinsonian disorders.

Journal of Alzheimer's disease reports

Apraxia of Speech in the Spontaneous Speech of Nonfluent/Agrammatic Primary Progressive Aphasia.

Ver todos os 404 no EuropePMC

Próxima:Associações

Associações

Organizações que acompanham esta doença — pra ter apoio e orientação

Ainda não temos associações cadastradas para Síndrome corticobasal.

É de uma associação que acompanha esta doença? Fale com a gente →

Próxima:Comunidades

Comunidades

Grupos ativos de quem convive com esta doença aqui no Raras

Ainda não existe comunidade no Raras para Síndrome corticobasal

Pacientes, familiares e cuidadores se organizam em comunidades pra compartilhar experiências, fazer perguntas e se apoiar. Você pode ser o primeiro.

Próxima:Tire suas dúvidas

Tire suas dúvidas

Perguntas, dicas e experiências compartilhadas aqui na página

Participe da discussão

Faça login para postar dúvidas, compartilhar experiências e interagir com especialistas.

Fazer login

Próxima:Doenças relacionadas

Doenças relacionadas

Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico

Ordenadas pelo número de sintomas em comum.

Paralisia oculomotora supranuclear

18 em comum

ORPHA:98687

Paresia supranuclear progressiva

18 em comum

ORPHA:683

Síndrome de paralisia supranuclear progressiva atípica

16 em comum

ORPHA:99750

NÃO RARA NA EUROPA: Doença de Parkinson

12 em comum

ORPHA:319705

Doença de Parkinson de início juvenil

11 em comum

ORPHA:2828

Paralisia supranuclear progressiva-síndrome corticobasal

11 em comum

ORPHA:240103

Síndrome distonia-plus

11 em comum

ORPHA:98203

Doença de Parkinson hereditária com início tardio

ORPHA:411602

Demência fronto-temporal

Calcinose-estrio-pálido-dentada bilateral

ORPHA:282

Variante comportamental da demência frontotemporal

ORPHA:1980

Lipofuscinose ceroide neuronal

ORPHA:275864