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Síndrome corticobasal
ORPHA:454887CID-10 · G31.0DOENÇA RARA
MuscularInício adulta
Também conhecida comoSCB

A síndrome corticobasal (SCB) é uma doença neurológica rara e progressiva que afeta o cérebro, caracterizada por diversos problemas nos movimentos e dificuldades cognitivas, como rigidez mais acentuada em um lado do corpo, movimentos lentos, dificuldade em fazer movimentos coordenados com braços e pernas, e problemas para entender a posição das coisas no espaço.

Em construçãohistóricoSugerir correção
Mantido por Agente Raras·Colaborar como especialista →

Introdução

O que você precisa saber de cara

💬
EM LINGUAGEM SIMPLES

A síndrome corticobasal é uma doença neurológica rara que compromete progressivamente os movimentos e as funções mentais no adulto ou idoso. A família costuma notar rigidez em um dos lados do corpo, lentidão incomum e grande dificuldade para realizar tarefas simples com os braços ou pernas. Podem surgir também alterações no equilíbrio, problemas na fala e falhas na memória. A doença não possui um PCDT próprio no Ministério da Saúde, mas o SUS prevê atendimentos de reabilitação para pessoas com doenças raras.

📋
Informacoes curadas por IA — podem conter imprecisoes

A síndrome corticobasal (SCB) é uma doença neurológica rara e progressiva que afeta o cérebro, caracterizada por diversos problemas nos movimentos e dificuldades cognitivas, como rigidez mais acentuada em um lado do corpo, movimentos lentos, dificuldade em fazer movimentos coordenados com braços e pernas, e problemas para entender a posição das coisas no espaço.

Pesquisas ativas
30 ensaios
61 total registrados no ClinicalTrials.gov
Publicações científicas
1.016 artigos
Último publicado: 2026 Apr 15

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
Unknown
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Worldwide
Início
Adult
+ elderly
🏥
SUS: Cobertura mínimaScore: 15%
2 procedimentos SIGTAPCID-10: G31.0
🇧🇷Dados SUS / DATASUS
EXAMES E PROCEDIMENTOS RELACIONADOS (2)
•
Sequenciamento completo do exoma (WES)
•
Atendimento em reabilitação — doenças raras
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Entender a doença

Do básico ao detalhe, leia no seu ritmo

Preparando trilha educativa...

Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

💪
Músculos
5 sintomas
🧠
Neurológico
5 sintomas
🦴
Ossos e articulações
1 sintomas

+ 12 sintomas em outras categorias

Características mais comuns

90%prev.
Mioclonias
Muito frequente (99-80%)
90%prev.
Rigidez muscular extrapiramidal progressiva
Muito frequente (99-80%)
90%prev.
Parkinsonismo
Muito frequente (99-80%)
55%prev.
Distúrbio da marcha
Frequente (79-30%)
55%prev.
Mioclonia de membro
Frequente (79-30%)
55%prev.
Bradicinesia
Frequente (79-30%)
23sintomas
Muito frequente (3)
Frequente (13)
Ocasional (4)
Muito raro (2)
Sem dados (1)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 23 características clínicas mais associadas, ordenadas por frequência.

MiocloniasMyoclonus
Muito frequente (99-80%)90%
Rigidez muscular extrapiramidal progressivaProgressive extrapyramidal muscular rigidity
Muito frequente (99-80%)90%
ParkinsonismoParkinsonism
Muito frequente (99-80%)90%
Distúrbio da marchaGait disturbance
Frequente (79-30%)55%
Mioclonia de membroLimb myoclonus
Frequente (79-30%)55%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico1.016PubMed
Últimos 10 anos200publicações
Pico202580 papers
Linha do tempo
2026Hoje · 2026🧪 2005Primeiro ensaio clínico📈 2025Ano de pico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
3Fase 31
2Fase 26
1Fase 14
·Pré-clínico50
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 61 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Síndrome corticobasal

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

Onde estão os ensaios

Com ensaio aberto em 8 países. O ponto verde marca onde há vaga agora.

🟢 Recrutando agora

21 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

NCT07844655 · Wellness in PSP and CBDRecrutando
NA🇨🇦 Canadá
NCT07805967 · Multi-Center Study of Natural History in Atypical Parkinsoni…Recrutando
🇨🇳 China
NCT07291687 · tDCS as Treatment for Motor FunctionRecrutando
NA🇨🇦 Canadá
NCT07000851 · Imaging Studies in Corticobasal SyndromeRecrutando
🇺🇸 Estados Unidos
NCT06613204 · STELLA-FTD: Examination of a Behavior Change Intervention fo…Recrutando
NA🇺🇸 Estados Unidos
NCT06932809 · Study of Biodistribution, Metabolism, Excretion and Brain Up…Recrutando
EARLY_PHASE1🇺🇸 Estados Unidos
NCT06596746 · Neurodegenerative Diseases Progression Markers (MARKERS-NDD)Recrutando
🇮🇹 Itália
NCT06949865 · AI-Enhanced Optimization of Acute Levodopa Challenge TestRecrutando
🇨🇳 China
NCT05653778 · Scrambler Therapy for Corticobasal Syndrome-Associated PainRecrutando
NA🇺🇸 Estados Unidos
NCT06174948 · The Use of the CUE1/CUE1+ in People With Parkinson's Disease…Recrutando
NA🇬🇧 Reino Unido
NCT06162013 · The NADAPT Study: a Randomized Double-blind Trial of NAD Rep…Recrutando
PHASE2🇳🇴 Noruega
NCT06529744 · Improving Prognostic Confidence in Neurodegenerative Disease…Recrutando
🇨🇦 Canadá
NCT06645626 · Utilisation of Health Services and Quality of Life in Patien…Recrutando
🇬🇧 Reino Unido
NCT04715399 · UPenn Observational Research Repository on Neurodegenerative…Recrutando
🇺🇸 Estados Unidos
NCT04363684 · ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration…Recrutando
🇨🇦 Canadá · 🇺🇸 Estados Unidos
NCT03225144 · Investigating Complex Neurodegenerative Disorders Related to…Recrutando
🇺🇸 Estados Unidos
NCT03174938 · The Swedish BioFINDER 2 StudyRecrutando
NA🇸🇪 Suécia
NCT02964637 · Diagnosing Frontotemporal Lobar DegenerationRecrutando
🇨🇦 Canadá
NCT02194816 · Modifiable Variables in Parkinsonism (MVP)Recrutando
🇺🇸 Estados Unidos
NCT07222605 · Research Study for Patients With Neurological Diseases Which…Por convite
NA🇺🇸 Estados Unidos
NCT07049341 · Pilot Trial Evaluating Patient Experience With the MemorEM f…Por convite
NA🇺🇸 Estados Unidos

Outros ensaios clínicos

61 ensaios clínicos encontrados, 30 ativos.

Distribuição por fase
NCT07868328 · A Study to Evaluate the Safety, Tolerability and Pharmacodyn…Em breve
PHASE2
NCT07569367 · A Wearable Sensor Platform for Remote Monitoring of Individu…Em breve
🇺🇸 Estados Unidos
NCT07333898 · Digital Measurements of Motor and Voice Functions in FTDEm breve
NCT05956834 · A Multi-Modal Remote Monitoring Platform for Frontotemporal …Ativo
🇺🇸 Estados Unidos
NCT06870838 · Neuroinflammation in FTLDAtivo
🇳🇱 Países Baixos
NCT05222386 · Community Outreach for Palliative Engagement -- Parkinson Di…Ativo
NA🇺🇸 Estados Unidos
NCT05073471 · Music and Brain Stimulation for Upper Extremity Performance …Ativo
NA🇺🇸 Estados Unidos
NCT06209515 · Sociodemographic Factors and Criminal Behaviour Preceding Ne…Ativo
🇫🇮 Finlândia
NCT02994719 · Gait Analysis in Neurological DiseaseAtivo
🇺🇸 Estados Unidos
NCT05983588 · PROFIL Study to Investigate the Effect of GPB on NfL Levels …Concluído
PHASE2🇩🇪 Alemanha
NCT05127057 · Proactive and Integrated Management and Empowerment in Parki…Concluído
NA🇬🇧 Reino Unido
NCT06354933 · Neurological Soft Signs in Neurodegenerative DementiasConcluído
🇮🇹 Itália
NCT05067192 · Optimization of Morphomer-based Alpha-synuclein PET TracersConcluído
🇸🇪 Suécia
NCT04925622 · Complex Eye Movements in Parkinson's Disease and Related Mov…Concluído
🇺🇸 Estados Unidos
NCT04518059 · Misfolded Proteins in the Skin of People With Parkinson's Di…Concluído
🇺🇸 Estados Unidos
NCT04786158 · Subcutaneous Apomorphine in the Treatment of Progressive Sup…Concluído
🇫🇷 França
NCT03552484 · In-Home Care for Patients With PSP and Related DisordersConcluído
NA🇺🇸 Estados Unidos
NCT03325556 · Relapse Prevention Study of Pimavanserin in Dementia-related…Concluído
PHASE3Bulgaria · 🇨🇱 Chile · 🇨🇿 Tchéquia +10
NCT03545126 · Human CNS Tau Kinetics in TauopathiesConcluído
🇺🇸 Estados Unidos
NCT03076671 · More Than a Movement Disorder: Applying Palliative Care to P…Concluído
NA🇺🇸 Estados Unidos
NCT06224920 · Activity of Cerebral Networks, Amyloid and Microglia in Agin…Concluído
NCT03030586 · ADDIA Proof-of-Performance Clinical StudyConcluído
🇧🇪 Bélgica · 🇫🇷 França · 🇮🇹 Itália +2
NCT02874274 · Vaccination Uptake (VAX) in PDConcluído
NA🇺🇸 Estados Unidos
NCT03153371 · Early-onset Alzheimer's Disease Phenotypes: Neuropsychology …Concluído
🇺🇸 Estados Unidos
NCT02966145 · 4-Repeat Tauopathy Neuroimaging Initiative - Cycle 2Concluído
🇨🇦 Canadá · 🇺🇸 Estados Unidos
NCT02365922 · Advancing Research and Treatment for Frontotemporal Lobar De…Concluído
🇨🇦 Canadá · 🇺🇸 Estados Unidos
NCT02167594 · Tau Imaging in Subjects With Progressive Supranuclear Palsy,…Concluído
PHASE1🇺🇸 Estados Unidos
NCT02133846 · Safety Study of TPI-287 to Treat CBS and PSPConcluído
PHASE1🇺🇸 Estados Unidos
NCT02132052 · Defining Phenotypes of Movement Disorders :Parkinson's Plus …Concluído
🇺🇸 Estados Unidos
NCT01804452 · 4 Repeat Tauopathy Neuroimaging InitiativeConcluído
🇺🇸 Estados Unidos
NCT01056965 · Davunetide (AL-108) in Predicted Tauopathies - Pilot StudyConcluído
PHASE1🇺🇸 Estados Unidos
NCT01174771 · Repetitive Transcranial Magnetic Stimulation (TMS) for Progr…Concluído
🇺🇸 Estados Unidos
NCT00703677 · A Pilot Trial of Lithium in Subjects With Progressive Supran…Concluído
PHASE1, PHASE2🇬🇧 Reino Unido · 🇺🇸 Estados Unidos
NCT00273897 · Electrical Polarization of the Brain in Corticobasal Syndrom…Concluído
PHASE2🇺🇸 Estados Unidos
NCT05638477 · Unstructured Eye Tracking as a Diagnostic and Prognostic Bio…UNKNOWN
NA🇮🇪 Irlanda
NCT04734379 · Rho Kinase (ROCK) Inhibitor in Tauopathies - 1UNKNOWN
PHASE2🇺🇸 Estados Unidos
NCT03297177 · Autologous Stem/Stromal Cells in Neurological Disorders and …UNKNOWN
NA🇺🇸 Estados Unidos
NCT03269201 · Brain Network Activation in Patients With Movement DisordersUNKNOWN
🇮🇱 Israel
NCT02778607 · PROgressive Supranuclear Palsy CorTico-Basal Syndrome Multip…UNKNOWN
🇬🇧 Reino Unido
NCT04883229 · tDCS and Speech Therapy for Motor Speech Disorders Caused by…Cancelado
NA
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
758 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 758

#1

Incidence and Survival Rates of Frontotemporal Lobar Degeneration: Population-Based Registry Study.

Neurology2026 Mar 24

Frontotemporal lobar degeneration (FTLD) can present as a behavioral or language variant (bvFTLD or a primary progressive aphasia [PPA], or as a syndrome with parkinsonism, such as corticobasal syndrome [CBS] or progressive supranuclear palsy [PSP]). The incidence of FTLD varies in epidemiologic studies, reaching 3 per 100,000 person-years. Only few data exist regarding survival times. We evaluated incidence and survival rates in a population-based registry with high coverage in Southern Germany. The epidemiologic ALS-FTLD registry Swabia covers a population of 8.4 million inhabitants in south-west Germany. Raw and age-standardized incidence rates, as well as incidence rate ratios (IRR) with 95% CIs were calculated. Median survival time was estimated for different FTLD variants using the Kaplan-Meier method. Between 2015 and 2022, 515 patients with FTLD (mean age at diagnosis 68.0 ± 9.5 years, 59.8% men) were registered. The median diagnostic delay was 24.8 months. The most common variant was bvFTLD (n = 185, 35.9%; 66.5% men), followed by PPA (n = 147, 28.5%; 51.0% men), PSP (n = 133, 25.8%; 62.9% men), and CBS (n = 22, 4.3%; 50% men). The overall FTLD incidence was 0.77 (95% CI 0.71-0.84), and the age-standardized incidence was 0.76 (95% CI 0.69-0.82) per 100.000 person-years. The age-standardized incidence was higher in men than in women, with an IRR of 1.73 (95% CI 1.44-2.00). In men, incidence increased from the age 50 years, primarily due to bvFTD, whereas in women this rise was primarily due to PSP. The median survival (N = 392) from diagnosis was 53.6 months (95% CI 50.9-62.0) overall, 73.1 months (95% CI 63.6-82.8) for patients with PPA, 42.8 months (95% CI 35.1-64.3) for patients with bvFTD, and 49.5 months (95% CI 39.2-53.7) for patients with PPS/CBS. We observed a raw incidence rate of 0.77, thus considerably lower than in most previous reports. Incidence was substantially higher in men than in women. The prognosis from the time of diagnosis depended highly on the specific FTLD subtype. Our data are based on the large sample size and high capture rate of a central European population-based registry.

#2

Multi-model Diffusion MRI Signatures in Atypical Parkinsonian Disorders.

medRxiv : the preprint server for health sciences2026 Feb 05

Distinguishing atypical parkinsonian disorders (APS) from Parkinson's disease (PD) remains challenging due to overlapping clinical features, yet accurate differentiation is critical for prognosis and treatment. Here, we employed multi-model diffusion MRI (dMRI) analysis to characterize microstructural alterations across corticobasal syndrome (CBS), progressive supranuclear palsy-Richardson syndrome (PSP-RS) and PD, with the aim of identifying which dMRI model provides optimum differentiation. We analyzed 25 CBS, 42 PSP-RS, and 21 PD participants compared to 35 age and sex-matched controls. Using a clinically feasible 3-shell high angular resolution diffusion imaging (HARDI) protocol, we applied 11 metrics from five complementary dMRI models-diffusion tensor imaging (DTI), free-water-eliminated model of DTI (FWE), neurite orientation dispersion and density imaging (NODDI), tissue-weighted NODDI, and Fixel Density (FD) in fixel-based analysis (FBA) -to comprehensively assess regional white and gray matter integrity. Group differentiation was assessed using Cohen's d effect sizes and spearman correlations were assessed between dMRI metrics and clinical scales. Distinct microstructural signatures were observed across disorders and the sensitivity of the dMRI models differed. In group contrasts, DTI and NODDI-derived metrics consistently captured the strongest effects in midbrain and peduncular pathways for PSP-RS, whereas precentral and corticospinal alterations in CBS were most prominent using NODDI and FBA measures. Free-water-corrected metrics showed attenuated group differences. Across clinical-diffusion analyses, NODDI metrics exhibited the most robust associations with disease severity, while DTI and FWE measures detected more limited, regionally constrained effects. Together, these findings highlight complementary yet distinct sensitivities of tensor, free-water, multi-compartment, and fixel-based models to APS-related neurodegeneration.

#3

Interpeduncular Angle: A Possible Marker to Differentiate Atypical Parkinsonism from Idiopathic Parkinson's Disease.

Annals of Indian Academy of Neurology2026 Jan 01

Atypical parkinsonian disorders (APD), such as progressive supranuclear palsy (PSP), multiple system atrophy (MSA), corticobasal syndrome (CBS), and Lewy body dementia (LBD) are frequently misdiagnosed, commonly as Parkinson's disease (PD). The study aims to assess the utility of the interpeduncular angle (IPA) in distinguishing APD from PD across age ranges. This retrospective study was conducted with 225 patients (75 with APD, 75 with PD, and 75 healthy controls). Patients were categorized into three age groups: (51-60, 61-70, and 71-80 years). Two independent raters measured the IPA from T1-weighted axial brain magnetic resonance images (MRIs) at a level below the mammillary bodies using standardized measurement techniques. The APD group included 51 (68%) with PSP, 16 (21.33%) with MSA, 5 (6.67%) with LBD, and 3 (4%) with CBS. Bland-Altman analysis for angle measurement suggested good to excellent agreement between raters ( P < 0.001). IPA measurements among the different diagnostic groups showed that PSP was higher than controls ( P < 0.001) and PD ( P < 0.001), and MSA was higher than controls ( P < 0.001) and PD ( P = 0.003). There was no significant association between IPA and age in the APD phenotypes. With increasing age, the significance between APD and IPD groups decreased ( P < 0.001 in 51-60 years to P = 0.686 in 71-80 years). Receiver Operating Characteristic (ROC) analysis revealed increasing IPA thresholds for PSP versus PD (67.66° in 51-60 years to 75.71° in 71-80 years). IPA is not reliable in differentiating APD, particularly PSP and MSA, from PD and controls.

#4

Utility of Locus Coeruleus Signal Intensity on High-resolution T1-weighted MR Imaging with Magnetization Transfer for Differentiating Parkinson's Disease from Atypical Parkinsonism.

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine2026 Feb 26

This study aimed to evaluate the diagnostic utility of locus coeruleus (LC) signal intensity on high-resolution T1-weighted imaging with magnetization transfer (T1WI with MT) for distinguishing Parkinson's disease (PD) from a broad range of atypical parkinsonism (AP) subtypes, including early-stage cases. We retrospectively analyzed T1WI with MT data from 214 participants, including patients with PD (n = 125), corticobasal syndrome (CBS, n = 12), multiple system atrophy (MSA, n = 16), progressive supranuclear palsy (PSP, n = 19), essential tremor (n = 17), vascular parkinsonism (n = 4), drug-induced parkinsonism (DIP, n = 7), and healthy subjects (HS, n = 14). Circular ROIs were placed on the LC and substantia nigra pars compacta to calculate contrast ratios (CRs). Conventional MRI findings of AP, focusing on characteristic regional atrophy patterns, were also evaluated. Diagnostic performance was assessed using receiver operating characteristic (ROC) analysis. A subanalysis was performed for early-stage cases (within 2 years of onset). Three independent neuroradiologists evaluated T1WI with MT, and interobserver agreement was assessed using intraclass correlation coefficients (ICC). The LC-CR was significantly lower in PD than in HS (P < 0.01) and all AP subtypes except DIP (P = 0.37). ROC analysis revealed that LC-CR had the highest diagnostic accuracy for differentiating PD from AP (area under the curve [AUC] = 0.83, sensitivity = 67%, specificity = 90%). In early-stage cases, LC-CR maintained high specificity (98%) with an AUC of 0.80. The diagnostic utility of LC-CR was comparable or superior to conventional MRI findings in distinguishing PD from CBS, MSA, and PSP. Interobserver agreement for LC-CR measurements was good, with an ICC of 0.87 (95% confidence interval: 0.85-0.89). LC-CR measured on T1WI with MT serves as a reliable imaging biomarker for differentiating PD from various forms of AP, even in early disease stages.

#5

[Basal ganglia and movement disorders : Part 1: the parkinsonian spectrum-Neuroradiological patterns and diagnostic considerations].

Radiologie (Heidelberg, Germany)2026 Mar 16

Movement disorders are a frequent yet diagnostically unspecific reason for referral in routine neuroradiological practice. Hypokinetic syndromes with parkinsonism in particular regularly raise the question of an underlying neurodegenerative disorder, while requiring careful differentiation from atypical parkinsonian syndromes and secondary causes. This first part of the review focuses on the neuroradiological assessment of degenerative movement disorders, with an emphasis on the parkinsonian spectrum. It is grounded in the functional anatomy of the basal ganglia and their integration into motor networks. Building on this framework, a practice-oriented diagnostic approach is presented in which clinical phenotypes, temporal evolution, and accompanying symptoms serve as guiding criteria for targeted image interpretation. The article addresses idiopathic Parkinson's disease as well as atypical parkinsonian syndromes, in particular progressive supranuclear palsy, multiple system atrophy, and corticobasal syndrome. Typical and atypical magnetic resonance imaging (MRI) patterns, established morphometric markers, and the diagnostic limitations of visual signs such as the swallow-tail sign are critically discussed. In addition, neuromelanin-sensitive MRI, susceptibility-based techniques, and artificial intelligence (AI)-supported approaches are reviewed, with explicit consideration of their current limitations. The aim of this contribution is to enable a structured and clinically robust neuroradiological assessment of parkinsonism and to use imaging in a targeted manner for differential diagnosis and guidance of further diagnostic work-up. Bewegungsstörungen gehören zu den häufigen, zugleich aber unspezifischen Zuweisungsgründen in der neuroradiologischen Routine. Gerade hypokinetische Syndrome mit Parkinsonismus werfen regelmäßig die Frage nach einer zugrunde liegenden neurodegenerativen Erkrankung auf, erfordern jedoch eine sorgfältige Abgrenzung gegenüber atypischen Parkinson-Syndromen und sekundären Ursachen. Der vorliegende erste Teil der Übersichtsarbeit widmet sich der neuroradiologischen Einordnung degenerativer Bewegungsstörungen mit Schwerpunkt auf dem Parkinson-Spektrum. Ausgangspunkt ist die funktionelle Anatomie der Basalganglien und ihre Einbindung in motorische Netzwerke. Darauf aufbauend wird ein praxisorientierter diagnostischer Ansatz vorgestellt, bei dem klinische Phänotypen, zeitlicher Verlauf und Begleitsymptome als leitende Kriterien für die gezielte Bildanalyse dienen. Im Fokus stehen das idiopathische Parkinson-Syndrom sowie atypische Parkinson-Syndrome, insbesondere die progressive supranukleäre Blickparese, die Multisystematrophie und das kortikobasale Syndrom. Typische und atypische Muster in der Magnetresonanztomographie (MRT), etablierte morphometrische Marker sowie die diagnostischen Grenzen visueller Zeichen wie des Swallow-tail-Zeichens werden kritisch eingeordnet. Ergänzend werden Neuromelanin-sensitive MRT, suszeptibilitätsbasierte Verfahren und KI-gestützte Ansätze inklusive ihrer Limitationen diskutiert. Ziel dieses Beitrags ist es, eine strukturierte und klinisch belastbare neuroradiologische Befundung bei Parkinsonismus zu ermöglichen und die Bildgebung gezielt zur Differenzialdiagnostik und zur Steuerung weiterführender Untersuchungen einzusetzen.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC404 artigos no totalmostrando 193

2026

[Basal ganglia and movement disorders : Part 1: the parkinsonian spectrum-Neuroradiological patterns and diagnostic considerations].

Radiologie (Heidelberg, Germany)
2026

Improving access to care through transportation and internet use for patients with atypical parkinsonism: A pilot study.

Clinical parkinsonism &amp; related disorders
2026

Incidence and Survival Rates of Frontotemporal Lobar Degeneration: Population-Based Registry Study.

Neurology
2026

Multi-model Diffusion MRI Signatures in Atypical Parkinsonian Disorders.

medRxiv : the preprint server for health sciences
2026

Real-world evaluation of Armstrong's criteria in corticobasal degeneration: Phenotypic overlap and diagnostic challenges.

Parkinsonism &amp; related disorders
2026

Automated differentiation of parkinsonian disorders: an ROI-based analysis of subcortical shape and cortical surface features.

Cognitive neurodynamics
2026

Potential role of MRI to optimize clinical trial design for progressive supranuclear palsy and corticobasal degeneration.

The journal of prevention of Alzheimer's disease
2026

Localized Iron Deposition and Shape Changes of Cerebellar Dentate in Progressive Supranuclear Palsy Clinical Variants.

Movement disorders : official journal of the Movement Disorder Society
2026

Voice and Speech in Atypical Parkinsonian Disorders.

Movement disorders clinical practice
2025

CORTICOBASAL SYNDROME PRESENTING AS A PROGRESSIVE HEMIPARETIC SYNDROME: A CASE REPORT.

Georgian medical news
2025

Praja1 E3 ubiquitin ligase and the role it plays in neurodegeneration.

The FEBS journal
2026

White matter hyperintensities in the deep cerebral venous territory differ between subcortical and cortical 4-repeat tauopathies.

Parkinsonism &amp; related disorders
2025

MAPT p.V363I mutation in a patient with presenile dementia and late amyotrophic lateral sclerosis.

Amyotrophic lateral sclerosis &amp; frontotemporal degeneration
2025

The Paper-Toss Test: enhancing bedside recognition of corticobasal syndrome.

Frontiers in neurology
2025

Progressive supranuclear palsy and corticobasal syndrome: cross-sectional study of palliative care needs.

BMJ supportive &amp; palliative care
2025

Functional network collapse in neurodegenerative disease.

Nature communications
2026

Interpeduncular Angle: A Possible Marker to Differentiate Atypical Parkinsonism from Idiopathic Parkinson's Disease.

Annals of Indian Academy of Neurology
2025

The genetic landscape of frontotemporal lobar degeneration: investigation of a diagnostic cohort of 2747 probands.

Brain : a journal of neurology
2025

Potential Role of Transferrin and Vascular Cell Adhesion Molecule 1 in Differential Diagnosis Among Patients with Tauopathic Atypical Parkinsonian Syndromes.

Diagnostics (Basel, Switzerland)
2025

Chorea and Levodopa-Induced Dyskinesia in Corticobasal Syndrome: Two Case Reports with Pathological Insights and Literature Review.

Movement disorders clinical practice
2026

Utility of Locus Coeruleus Signal Intensity on High-resolution T1-weighted MR Imaging with Magnetization Transfer for Differentiating Parkinson's Disease from Atypical Parkinsonism.

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine
2025

The Effects of Multimodal Exercise on Sleep Quality and Architecture, Motor Function, Cognition, Fatigue, and Systemic Inflammation in Corticobasal Syndrome: A Case Report.

Physical therapy
2025

Discordant cerebrospinal fluid and positron emission tomography amyloid biomarkers in an APP mutation carrier presenting corticobasal syndrome.

Alzheimer's &amp; dementia : the journal of the Alzheimer's Association
2025

Early subtypes and progressions of progressive supranuclear palsy: a data-driven brain bank study.

Journal of neurology
2025

Expanding the genetic spectrum of corticobasal syndrome: novel CCNF p.M394L variant from a South Asian cohort.

Neurocase
2025

Unraveling the mystery of alien hand syndrome: when your hand has a mind of its own.

Orphanet journal of rare diseases
2026

A Biomarker-Based Classification of Corticobasal Syndrome.

Movement disorders : official journal of the Movement Disorder Society
2025

A Bayesian analysis of diagnostic timelines across Alzheimer's disease, frontotemporal dementia, and other neurodegenerative conditions.

Alzheimer's &amp; dementia (Amsterdam, Netherlands)
2025

Tracking prodromal Parkinson's disease: a five-year follow-up of the PARCAS cohort.

Frontiers in neurology
2025

Neuroanatomical normative modelling in frontotemporal lobar degeneration: higher heterogeneity in the behavioural variant.

Journal of neurology
2026

Elevated levels of cerebrospinal fluid soluble triggering receptor expressed on myeloid cells 2 in multiple system atrophy: a marker of disease-associated microglial activation.

Journal of neural transmission (Vienna, Austria : 1996)
2025

α-Synuclein seed amplification assay positivity beyond synucleinopathies.

EBioMedicine
2026

Possible Contribution of Parietal Lobe Dysfunction to Hand-Foot Synkinesis in Corticobasal Syndrome: A Case Report.

Journal of movement disorders
2026

Asymmetric Applause Sign in Corticobasal Syndrome: A Case of Clonic Motor Perseveration.

Movement disorders clinical practice
2025

Acoustic Analysis of Apraxia of Speech in a Japanese Patient With Nonfluent/Agrammatic Variant Primary Progressive Aphasia: A Case Study.

Cureus
2025

A Review of FDG-PET in Progressive Supranuclear Palsy and Corticobasal Syndrome.

International journal of molecular sciences
2025

Incidence and Prevalence of Frontotemporal Dementia: A Systematic Review and Meta-Analysis.

JAMA neurology
2025

Scrambler Therapy for the Treatment of Chronic Neuropathic Pain in Atypical Parkinsonian Disorders: A Case Series.

Pain medicine case reports
2026

Progressive Supranuclear Palsy-A Global Review.

Movement disorders clinical practice
2025

Detecting amyloid and tau pathology in Parkinson's disease, 4R-tauopathies and control subjects with plasma pTau217.

Frontiers in neurology
2025

Alzheimer's disease traits in Parkinson's disease without α-synuclein seeding.

Alzheimer's &amp; dementia : the journal of the Alzheimer's Association
2025

Prevalence of NOTCH2NLC and FMR1 Repeat Expansions in Atypical Parkinsonism Compared to Asymptomatic Elderly Individuals.

Movement disorders : official journal of the Movement Disorder Society
2025

[Diagnosis of Alzheimer's disease using biological markers in corticobasal syndrome].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
2026

Serious Illness Conversation in the Care of Atypical Parkinsonian Disorders: A Practical Guide for Neurology Clinicians.

Movement disorders clinical practice
2025

Cortical hyperexcitability in corticobasal syndrome as revealed by giant somatosensory evoked potentials.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
2025

Differences in neuropsychological performance across clinical variants of progressive supranuclear palsy.

Journal of the International Neuropsychological Society : JINS
2025

Connectivity as a universal predictor of tau progression in atypical Alzheimer's disease.

Brain : a journal of neurology
2025

Progressive Supranuclear Palsy and Corticobasal Syndrome.

Continuum (Minneapolis, Minn.)
2025

Differences in gait apraxia due to reduced regional cerebral blood flow in the supplementary motor area in corticobasal syndrome: a report of two cases.

BMC neurology
2025

Cognitive Decline in Parkinsonism: From Clinical Phenotypes to the Genetic Background.

Biomedicines
2025

Diagnostic utility of tectal plate measures in clinical variants of progressive supranuclear palsy.

Journal of neurology
2025

Delayed progressive apraxia of speech: A novel clinical entity distinct from primary progressive aphasia - A descriptive case series.

Journal of the neurological sciences
2025

Frontotemporal Lobar degeneration with TDP-43 presenting as progressive supranuclear palsy syndrome.

Acta neuropathologica communications
2025

Accelerated Intermittent Theta Burst Stimulation Combined with Balance Training Improves Balance in an Individual with Corticobasal Syndrome.

Movement disorders clinical practice
2025

Progression and natural history of Atypical Parkinsonism (ATPARK): Protocol for a longitudinal follow-up study from an underrepresented population.

PloS one
2025

Neurological soft signs in neurodegenerative dementias: Results of the DemeNSS study.

PCN reports : psychiatry and clinical neurosciences
2025

Pick's disease presenting as progressive apraxia of speech: Atypical clinical and neuroimaging features in three autopsy-confirmed cases.

Clinical neurology and neurosurgery
2025

Evaluation of disproportionately enlarged subarachnoid-space hydrocephalus in progressive supranuclear palsy.

Brain communications
2025

Prospective longitudinal cohort of Argentinean patients with progressive supranuclear palsy and corticobasal syndrome: A platform for epidemiological and translational research.

Clinical parkinsonism &amp; related disorders
2025

A narrative review of serum biomarkers in progressive supranuclear palsy, corticobasal syndrome, and related disorders.

Journal of neural transmission (Vienna, Austria : 1996)
2025

Cognitive Performance in Parkinson's Spectrum Disorders: a comparative study of patients with Parkinson's Disease, Parkinson's Disease Dementia, Dementia With Lewy Bodies, Progressive Supranuclear Palsy, and Corticobasal Syndrome.

Assessment
2025

Atypical Imaging Findings in Corticobasal Syndrome: A Case Report.

Journal of movement disorders
2025

Neurophysiology of Atypical Parkinsonian Syndromes: A Study Group Position Paper.

Movement disorders : official journal of the Movement Disorder Society
2025

Computer Vision Technologies in Movement Disorders: A Systematic Review.

Movement disorders clinical practice
2025

Plasma biomarkers of amyloid, tau & neuroinflammation in Alzheimer's disease and corticobasal syndrome.

European archives of psychiatry and clinical neuroscience
2025

Differentiating Progressive Supranuclear Palsy and Corticobasal Syndrome: Insights from Cerebrospinal Fluid Biomarkers-A Narrative Review.

Medicina (Kaunas, Lithuania)
2025

[18F]Florzolotau PET for the Differential Diagnosis of Parkinsonism in Patients with Suspected 4-Repeat Tauopathies.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine
2025

Cognitive and neuropsychiatric profiles distinguish atypical parkinsonian syndromes.

Brain : a journal of neurology
2025

Cerebrospinal fluid and blood neurofilament light chain in Parkinson's disease and atypical parkinsonian syndromes: a systematic review and Bayesian network meta-analysis.

Journal of neurology
2025

Neurofilament Light Chain in Cerebrospinal Fluid and Blood in Multiple System Atrophy: A Systematic Review and Meta-Analysis.

Brain sciences
2025

Case report: Behavioral variant FTD confounding a language variant FTD in a case of PSP-CBS.

Frontiers in dementia
2025

Analysis of C9orf72 repeat length in progressive supranuclear palsy, corticobasal syndrome, corticobasal degeneration, and atypical parkinsonism.

Journal of neurology
2025

Identical Seeding Characteristics and Cryo-EM Filament Structures in FTLD-Synuclein and Typical Multiple System Atrophy.

Neuropathology and applied neurobiology
2025

Unveiling the enigmatic: Primary progressive apraxia of speech - A case report.

Clinical parkinsonism &amp; related disorders
2025

Relationships between hypometabolism and both β-amyloid and tau PET in corticobasal syndrome.

Alzheimer's &amp; dementia : the journal of the Alzheimer's Association
2025

Comprehensive cross-sectional and longitudinal comparisons of plasma glial fibrillary acidic protein and neurofilament light across FTD spectrum disorders.

Molecular neurodegeneration
2025

Distinct spatiotemporal atrophy patterns in corticobasal syndrome are associated with different underlying pathologies.

Brain communications
2024

A progranulin gene deletion in frontotemporal lobar degeneration with corticobasal syndrome in a TREDEM case report.

Journal of Alzheimer's disease reports
2025

Subcortical tau burden correlates with regional brain atrophy and plasma markers in four-repeat tauopathy parkinsonism.

Journal of Parkinson's disease
2025

Autopsy-proven patient with corticobasal degeneration presenting with visuo-constructive disorders as initial symptoms: How advanced MRI sequences can help clinical practice.

Journal of Alzheimer's disease : JAD
2025

Overlap in the diagnostic criteria of frontotemporal dementia syndromes with parkinsonism.

Journal of Alzheimer's disease : JAD
2025

Predicting survival rate by plasma biomarkers and clinical variables in syndromes associated with frontotemporal lobar degeneration.

Alzheimer's &amp; dementia : the journal of the Alzheimer's Association
2025

[The experience of diagnosing Alzheimer's disease based on the study of cerebrospinal fluid biomarkers].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
2025

Atypical Alzheimer's dementia: Addressing the subtypes, epidemiology, atypical presentations, diagnostic biomarkers, and treatment updates.

Disease-a-month : DM
2024

Diagnosis and Management of Progressive Corticobasal Syndrome.

Current treatment options in neurology
2025

Cognitive impairment in PSP compared with PD: assessment by clinical subtype and longitudinal change.

BMJ neurology open
2025

Frequency of anti-IgLON5 disease in patients with a typical clinical presentation of progressive supranuclear palsy/corticobasal syndrome.

Parkinsonism &amp; related disorders
2025

L266V MAPT Gene Mutation Associated With Frontotemporal Dementia, Progressive Supranuclear Palsy, and Corticobasal Syndrome.

The Journal of neuropsychiatry and clinical neurosciences
2025

Altered cortical network dynamics during observing and preparing action in patients with corticobasal syndrome.

Neurobiology of disease
2025

Addressing inter individual variability in CSF levels of brain derived proteins across neurodegenerative diseases.

Scientific reports
2024

Two novel variants in GRN: the relevance of CNV analysis and genetic screening in FTLD patients with a negative family history.

Journal of neurology
2024

Lexical markers of disordered speech in primary progressive aphasia and 'Parkinson-plus' disorders.

Brain communications
2024

Corticobasal degeneration: An update.

Ideggyogyaszati szemle
2024

Transdiagnostic Network Localization of Social, Language, and Motor Symptoms in Patients With Frontotemporal Lobar Degeneration.

Neurology
2025

Caregiver perspectives enable accurate diagnosis of neurodegenerative disease.

Alzheimer's &amp; dementia : the journal of the Alzheimer's Association
2025

An SBM and TBSS Analysis in Early-stage Patients With Alzheimer's Disease, Lewy Body Dementias, and Corticobasal Syndrome.

Journal of geriatric psychiatry and neurology
2024

Japanese longitudinal biomarker study in progressive supranuclear palsy and corticobasal degeneration: Clinical features of the first registered patients and short-term follow-up analysis.

Clinical parkinsonism &amp; related disorders
2025

Peripheral innate immunophenotype in neurodegenerative disease: blood-based profiles and links to survival.

Molecular psychiatry
2024

The possible connection between neutrophil-to-high-density lipoprotein ratio and cerebral perfusion in clinically established corticobasal syndrome: a pilot study.

Frontiers in neurology
2024

MRI-Based Multi-Class Relevance Vector Machine Classification of Neurodegenerative Diseases.

medRxiv : the preprint server for health sciences
2024

Asymmetry in Atypical Parkinsonian Syndromes-A Review.

Journal of clinical medicine
2025

Swiss cheese brain presenting as corticobasal syndrome.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2025

Corticobasal Syndrome: Are There Central or Peripheral Triggers?

Neurology. Clinical practice
2025

Frontotemporal Dementia Differential Diagnosis in Clinical Practice: A Single-Center Retrospective Review of Frontal Behavioral Referrals.

Neurology. Clinical practice
2024

Apraxia phenotypes and frontotemporal lobar degeneration.

Journal of neurology
2024

A framework for translating tauopathy therapeutics: Drug discovery to clinical trials.

Alzheimer's &amp; dementia : the journal of the Alzheimer's Association
2024

A case of corticobasal syndrome possibly associated with anti-Yo antibodies.

Current medical research and opinion
2024

Evaluation of Cerebrospinal Fluid α-Synuclein Seed Amplification Assay in Progressive Supranuclear Palsy and Corticobasal Syndrome.

Movement disorders : official journal of the Movement Disorder Society
2024

Combining cerebrospinal fluid and PI-2620 tau-PET for biomarker-based stratification of Alzheimer's disease and 4R-tauopathies.

Alzheimer's &amp; dementia : the journal of the Alzheimer's Association
2024

Clinical characteristics of Japanese patients with corticobasal degeneration.

Journal of the neurological sciences
2024

Predictors of Care Home Admission and Survival Rate in Patients With Syndromes Associated With Frontotemporal Lobar Degeneration in Europe.

Neurology
2024

CSF α-Synuclein Seed Amplification Assay in Patients With Atypical Parkinsonian Disorders.

Neurology
2024

Cerebrospinal Fluid Total and Phosphorylated Tau Protein in Behavioral Variant Frontotemporal Dementia, Progressive Supranuclear Palsy, Corticobasal Syndrome and Non-Fluent Agrammatic Primary Progressive Aphasia: A Systematic Review and Meta-Analysis.

Biomedicines
2024

A General Neurologist's Practical Diagnostic Algorithm for Atypical Parkinsonian Disorders: A Consensus Statement.

Neurology. Clinical practice
2024

Determinants of care partner burden in atypical Parkinsonian syndromes: A retrospective, multi-center analysis.

Clinical parkinsonism &amp; related disorders
2024

Unilateral tactile agnosia as an onset symptom of corticobasal syndrome.

Frontiers in human neuroscience
2024

Conventional magnetic resonance imaging key features for distinguishing pathologically confirmed corticobasal degeneration from its mimics: a retrospective analysis of the J-VAC study.

Neuroradiology
2025

Upper motor neuron-predominant motor neuron disease presenting as atypical parkinsonism: A clinicopathological study.

Brain pathology (Zurich, Switzerland)
2023

Extracellular vesicles from bodily fluids for the accurate diagnosis of Parkinson's disease and related disorders: A systematic review and diagnostic meta-analysis.

Journal of extracellular biology
2024

Phenotypic and Positron Emission Tomography with [18F]fluordeoxyglucose (FDG PET) differences in corticobasal syndrome: comparison of two cases.

Dementia &amp; neuropsychologia
2024

An ANXA11 P93S variant dysregulates TDP-43 and causes corticobasal syndrome.

Alzheimer's &amp; dementia : the journal of the Alzheimer's Association
2024

Brain perfusion SPECT in dementia: what radiologists should know.

Japanese journal of radiology
2024

Relationships between PET and blood plasma biomarkers in corticobasal syndrome.

Alzheimer's &amp; dementia : the journal of the Alzheimer's Association
2024

Expanding the Spectrum of GBA1-Associated Neurodegenerative Diseases in an Italian Family.

Movement disorders clinical practice
2024

Comparing classic-onset corticobasal syndrome to speech/language-onset corticobasal syndrome.

Parkinsonism &amp; related disorders
2024

Usefulness of Olfactory Bulb Measurement in 3D-FIESTA in Differentiating Parkinson Disease from Atypical Parkinsonism.

AJNR. American journal of neuroradiology
2024

Neurofilaments and progranulin are related to atrophy in frontotemporal lobar degeneration - A transdiagnostic study cross-validating atrophy and fluid biomarkers.

Alzheimer's &amp; dementia : the journal of the Alzheimer's Association
2024

Symptomatic Unilateral Carotid Artery Disease: An Uncommon but Reversible Cause of Corticobasal Syndrome.

The neurologist
2024

Subcortical tau is linked to hypoperfusion in connected cortical regions in 4-repeat tauopathies.

Brain : a journal of neurology
2024

The yes-no reversal phenomenon in patients with primary progressive apraxia of speech.

Cortex; a journal devoted to the study of the nervous system and behavior
2024

Pick's Disease Presenting as Tremulous Parkinsonism with Limited Levodopa Response-A Rare Cause of Corticobasal Syndrome.

Movement disorders clinical practice
2024

Progressive Supranuclear Palsy Syndrome: An Overview.

IBRO neuroscience reports
2025

An autopsy case of type A FTLD-TDP with a GRN mutation presenting with the logopenic variant of primary progressive aphasia at onset and with corticobasal syndrome subsequently.

Neuropathology : official journal of the Japanese Society of Neuropathology
2024

Anti-IgLON5 disease as a differential diagnosis of multiple system atrophy.

Parkinsonism &amp; related disorders
2024

Differential Synaptic Loss in β-Amyloid Positive Versus β-Amyloid Negative Corticobasal Syndrome.

Movement disorders : official journal of the Movement Disorder Society
2024

Localizing apraxia in corticobasal syndrome: a morphometric MRI study.

Cerebral cortex (New York, N.Y. : 1991)
2024

Detecting Abnormal Eye Movements in Patients with Neurodegenerative Diseases - Current Insights.

Eye and brain
2024

Accuracy of routinely collected hospital administrative discharge data and death certificate ICD-10 diagnostic coding in progressive supranuclear palsy and corticobasal syndrome: a systematic review and validation study.

Journal of neurology
2024

Clinical and Pathological Features of FTDP-17 with MAPT p.K298_H299insQ Mutation.

Movement disorders clinical practice
2024

Progression to corticobasal syndrome: a longitudinal study of patients with nonfluent primary progressive aphasia and primary progressive apraxia of speech.

Journal of neurology
2024

Evaluating the Effect of Alzheimer's Disease-Related Biomarker Change in Corticobasal Syndrome and Progressive Supranuclear Palsy.

Annals of neurology
2024

[Cortico-basal syndrome and cortico-basal degeneration: From the clinical diagnosis to the lesional substrate for an adapted care].

Geriatrie et psychologie neuropsychiatrie du vieillissement
2024

Greater white matter degeneration and lower structural connectivity in non-amnestic vs. amnestic Alzheimer's disease.

Frontiers in neuroscience
2024

Amyloid-β prediction machine learning model using source-based morphometry across neurocognitive disorders.

Scientific reports
2024

Evaluation of cerebrospinal fluid alpha-synuclein seed amplification assay in PSP and CBS.

medRxiv : the preprint server for health sciences
2024

Primary Progressive Apraxia of Speech Caused by TDP-43: A Case Report.

Neurology. Genetics
2024

SQSTM1 Pro392Leu presenting as a corticobasal syndrome with progressive nonfluent aphasia.

Parkinsonism &amp; related disorders
2024

Frequency and outcomes of gastrostomy insertion in a longitudinal cohort study of atypical parkinsonism.

European journal of neurology
2024

Two distinct degenerative types of nigrostriatal dopaminergic neuron in the early stage of parkinsonian disorders.

Clinical parkinsonism &amp; related disorders
2023

Planimetric and Volumetric Brainstem MRI Markers in Progressive Supranuclear Palsy, Multiple System Atrophy, and Corticobasal Syndrome. A Systematic Review and Meta-Analysis.

Neurology international
2024

Total Patient Delay: A Comparison of Patient and Clinician/Health System Delays in the Diagnosis of Progressive Supranuclear Palsy and Corticobasal Syndrome.

Movement disorders clinical practice
2024

Nucleus Basalis of Meynert Degeneration Predicts Cognitive Decline in Corticobasal Syndrome.

Biological psychiatry
2024

Phenotypic Spectrum of Progressive Supranuclear Palsy: Clinical Study and Apolipoprotein E Effect.

Journal of movement disorders
2024

Deep vein thrombosis and its risk factors in neurodegenerative diseases: A markedly higher incidence in Parkinson's disease.

Journal of the neurological sciences
2024

Dissecting the Clinical Heterogeneity and Genotype-Phenotype Correlations of MAPT Mutations: A Systematic Review.

Frontiers in bioscience (Landmark edition)
2024

Monash-Alfred protocol for assessment of atypical parkinsonian syndromes (MAP-APS).

BMJ neurology open
2024

Glucose Metabolism and Cognitive Decline in Progressive Supranuclear Palsy and Corticobasal Syndrome: A Preliminary Study.

Journal of clinical medicine
2024

Patients with Neurodegenerative Proteinopathies Exhibit Altered Tryptophan Metabolism in the Serum and Cerebrospinal Fluid.

ACS chemical neuroscience
2024

Neuropathological hints from CSF and serum biomarkers in corticobasal syndrome (CBS): a systematic review.

Neurological research and practice
2024

Association of Neurofilament Light Chain, [18F]PI-2620 Tau-PET, TSPO-PET, and Clinical Progression in Patients With β-Amyloid-Negative CBS.

Neurology
2024

Probable 4-Repeat Tauopathy Criteria Predict Brain Amyloid Negativity, Distinct Clinical Features, and FDG-PET/MRI Neurodegeneneration Patterns in Corticobasal Syndrome.

Movement disorders clinical practice
2024

Analysis of biomarkers in speculative CNS-enriched extracellular vesicles for parkinsonian disorders: a comprehensive systematic review and diagnostic meta-analysis.

Journal of neurology
2023

Clinical course of pathologically confirmed corticobasal degeneration and corticobasal syndrome.

Brain communications
2023

Clinical course in corticobasal syndrome and corticobasal degeneration: implications for diagnosis and management.

Brain communications
2023

Corticobasal syndrome mimicking Foix-Chavany-Marie syndrome with suggested 4-repeat tauopathy by tau PET.

BMC geriatrics
2023

Neuronal Antibody-Associated Corticobasal Syndrome.

Annals of Indian Academy of Neurology
2023

Migraine and Tension-type Headache in Parkinson's Disease and Progressive Supranuclear Palsy/Corticobasal Syndrome.

Annals of Indian Academy of Neurology
2024

The Role of Dual-Phase 18 F-FP-CIT PET to Early Diagnosis of Corticobasal Syndrome.

Clinical nuclear medicine
2023

[18F]PI-2620 Binding Patterns in Patients with Suspected Alzheimer Disease and Frontotemporal Lobar Degeneration.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine
2024

Optineurin in patients with Amyotrophic Lateral Sclerosis associated to atypical Parkinsonism in Tunisian population.

Amyotrophic lateral sclerosis &amp; frontotemporal degeneration
2024

Left and right corticobasal syndrome: comparison of cognitive profiles between metabolic imaging - matched groups.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2023

Lingual and Facial Myoclonus Associated with Early Corticobasal Syndrome.

Movement disorders clinical practice
2024

The Effectiveness of Transcranial Magnetic Stimulation in Treating Apraxia.

CNS &amp; neurological disorders drug targets
2023

Pick's disease presenting with corticobasal syndrome: A case report and clinicopathological review.

Clinical neuropathology
2023

Magnetic Susceptibility in Progressive Supranuclear Palsy Variants, Parkinson's Disease, and Corticobasal Syndrome.

Movement disorders : official journal of the Movement Disorder Society
2023

Grey-matter correlates of empathy in 4-Repeat Tauopathies.

NPJ Parkinson's disease
2023

Atypical findings: Atypical parkinsonian syndromes or Atypical parkinsonian syndromes look-alikes.

Clinical neurology and neurosurgery
2023

Detailed Assessment of 18F-THK5351 Distribution Pattern in the Midbrain: Comparison With Progressive Supranuclear Palsy and Corticobasal Syndrome.

Clinical nuclear medicine
2023

Cerebrospinal fluid and blood serum biomarkers in neurodegenerative proteinopathies: A prospective, open, cross-correlation study.

Journal of neurochemistry
2023

Large-scale proximity extension assay reveals CSF midkine and DOPA decarboxylase as supportive diagnostic biomarkers for Parkinson's disease.

Translational neurodegeneration
2023

Fiber-specific micro- and macroscopic white matter alterations in progressive supranuclear palsy and corticobasal syndrome.

NPJ Parkinson's disease
2023

A Case of Corticobasal Syndrome and Posterior Cortical Atrophy With Biomarkers of Alzheimer Disease.

Alzheimer disease and associated disorders
2023

[Autoimmune encephalitis and paraneoplastic neurological syndromes presenting atypical parkinsonism: a scoping review].

Rinsho shinkeigaku = Clinical neurology
2023

A non-invasive method for prediction of neurodegenerative diseases using gait signal features.

Procedia computer science
2023

High sensitivity of asymmetric 18F-THK5351 PET abnormality in patients with corticobasal syndrome.

Scientific reports
2023

Association of Choroid Plexus Volume With Serum Biomarkers, Clinical Features, and Disease Severity in Patients With Frontotemporal Lobar Degeneration Spectrum.

Neurology
2023

[18F]-FDopa positron emission tomography imaging in corticobasal syndrome.

Brain imaging and behavior
2023

Network Connectivity Alterations across the MAPT Mutation Clinical Spectrum.

Annals of neurology
2024

Detection of episodic nocturnal hypercapnia in patients with neurodegenerative disorders.

Sleep &amp; breathing = Schlaf &amp; Atmung
2023

Evaluation of α-synuclein in CNS-originating extracellular vesicles for Parkinsonian disorders: A systematic review and meta-analysis.

CNS neuroscience &amp; therapeutics
2023

Multiclass characterization of frontotemporal dementia variants via multimodal brain network computational inference.

Network neuroscience (Cambridge, Mass.)
2023

Large-scale activation likelihood estimation meta-analysis of parkinsonian disorders.

Brain communications
2023

Apraxia of Speech in the Spontaneous Speech of Nonfluent/Agrammatic Primary Progressive Aphasia.

Journal of Alzheimer's disease reports
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Conselhos e sociedades

Doenças relacionadas

Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico

Perguntas frequentes

O que as famílias mais perguntam sobre esta doença — cada resposta com a fonte de onde saiu

Respostas geradas por IA a partir das fontes citadas

A síndrome corticobasal é uma condição neurológica progressiva para a qual não há cura catalogada até o momento. O acompanhamento médico concentra-se no gerenciamento dos sintomas e na preservação da capacidade motora.

Referências

Fontes citadas no texto, publicações do grafo e bases de dados usadas neste verbete

10 publicações do grafo RarasNet (PubMed) · 6 bases de dados. Títulos, periódicos e PMIDs vêm direto da fonte, sem intermediação de IA.

  1. ORPHA:454887
    Orphanet
  2. GARD:13168
    GARD (NIH)
  3. Q1755684
    Wikidata

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Citar este verbete

Raras. (s.d.). Síndrome corticobasal. Em Raras — Enciclopédia de Doenças Raras do Brasil. https://raras.org/doenca/sindrome-corticobasal

Formato APA. Conteúdo sob CC BY 4.0 — reuso livre com atribuição.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Síndrome corticobasal
Compêndio · Raras BR

Síndrome corticobasal

ORPHA:454887 · MONDO:0018696
🇧🇷 Brasil SUS
SIGTAP
2 procedimentos
Geral
Prevalência
Unknown
CID-10
G31.0 · Atrofia cerebral circunscrita
Ensaios
30 ativos
Início
Adult, Elderly
Prevalência
0.0 (Worldwide)
MedGen
UMLS
C0393570
EuropePMC
Wikidata
Wikipedia
Papers 10a

📋 Origem dos dados

Esta página agrega dados de fontes públicas e oficiais. Dados sobre cobertura no SUS (PCDT, CEAF) são verificados ativamente por agente proativo (ver badge no infobox). Demais dados têm atribuição de fonte + data da última sincronização — clique para abrir o original.

Doença rara (ontologia)
fonte: Orphanet
Identificador unificado
fonte: MONDO
Indexação biomédica
fonte: MeSH (NLM)
Dado público estruturado
fonte: Wikidata
Rara