A síndrome neuroléptica maligna (SNM) é uma condição idiossincrática associada à administração de antipsicóticos e outros bloqueadores dopaminérgicos centrais e caracterizada por hipertermia, rigidez muscular, disfunção autonômica e alteração da consciência.
Introdução
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A síndrome neuroléptica maligna (SNM) é uma condição idiossincrática associada à administração de antipsicóticos e outros bloqueadores dopaminérgicos centrais e caracterizada por hipertermia, rigidez muscular, disfunção autonômica e alteração da consciência.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 32 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 54 características clínicas mais associadas, ordenadas por frequência.
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Genética e causas
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Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
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🇧🇷 Atendimento SUS — Síndrome de neuroléptico maligno
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Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 694
Long-term safety evaluation of mirtazapine: A real-world pharmacovigilance study based on the FAERS database.
Mirtazapine is widely used in the treatment of major depressive disorder (MDD), yet its real-world safety profile remains insufficiently evaluated. This study analyzed adverse event (AE, plural AEs) reports related to mirtazapine from the FDA Adverse Event Reporting System (FAERS) database between the first quarter of 2004 and the first quarter of 2025. Four disproportionality analysis methods were employed, including reporting odds ratio (ROR), proportional reporting ratio (PRR), Bayesian confidence propagation neural network (BCPNN), and multi-item gamma Poisson shrinker (MGPS). Additional analyses included sensitivity analysis, time-to-onset (TTO) evaluation, and Weibull distribution modeling. A total of 17,953 reports were included, with females accounting for 54.1% and males for 37.7%. In 48.4% of the reports, patients were aged between 18 and 65 years. Overall, 65.0% of the reports were submitted by healthcare professionals. Known AEs such as somnolence (n = 887, ROR = 4.57, PRR = 4.52, EBGM = 4.50, IC = 2.17), QT interval prolongation (n = 259, ROR = 7.35, PRR = 7.32, EBGM = 7.27, IC = 2.86), suicidal ideation (n = 601, ROR = 6.65, PRR = 6.59, EBGM = 6.55, IC = 2.71), and rhabdomyolysis (n = 146, ROR = 3.66, PRR = 3.65, EBGM = 3.64, IC = 1.87) showed positive signals. In addition, several unexpected AEs also exhibited positive signals, including restless legs syndrome (n = 305, ROR = 17.05, PRR = 16.97, EBGM = 16.65, IC = 4.06), neuroleptic malignant syndrome (n = 158, ROR = 13.77, PRR = 13.74, EBGM = 13.53, IC = 3.76), and nightmare (n = 279, ROR = 8.02, PRR = 7.99, EBGM = 7.93, IC = 2.99). TTO analysis showed that 59.52% of AEs occurred within the first month of treatment. The results of the sensitivity analyses further supported the robustness of these findings. This study systematically assessed the long-term safety profile of mirtazapine using 21 years of real-world pharmacovigilance data from the FAERS database. The findings provide important evidence to support safe clinical use of mirtazapine and emphasize the need for continuous safety monitoring.
Reduced striatal dopamine transmission as a transdiagnostic substrate of psychomotor retardation.
Psychomotor retardation, defined as generalized slowing of movement and speech, is a feature of several neurological and psychiatric disorders. In this review, we discuss the hypothesis that reduced striatal dopaminergic transmission is a transdiagnostic substrate for psychomotor retardation underlying the motor features of conditions such as Parkinson's disease, drug-induced parkinsonism, neuroleptic malignant syndrome, catatonia and depression. We examine the evidence across clinical, epidemiological, neuroimaging, laboratory and therapeutic studies. Parkinsonian disorders share slowed movement and a reduction in verbal output with catatonia and depression. Bradyphrenia, slowed cognitive processing, also occurs in Parkinson's disease and depression. In addition, there are close epidemiological relationships between depression and Parkinson's disease, and between catatonia and neuroleptic malignant syndrome. Neuroimaging studies also generally support the association of psychomotor retardation with reduced dopaminergic transmission, particularly in the dorsal striatum. CSF measurement of homovanillic acid (a dopamine catabolite) yields inconsistent results and is non-specific. Parkinson's disease and catatonia generally respond well to dopaminergic medication. In contrast, dopamine antagonists can induce both parkinsonism and catatonia. Our review is limited by the variability in measurement of psychomotor retardation and difficulty distinguishing between cognitive and motor slowing. It is also likely that other neurotransmitters, such as GABA and serotonin, play an important role in psychomotor speed. It is possible that dopaminergic deficits in psychiatric disorders represent functional disruptions, in contrast to the structural damage to the substantia nigra in Parkinson's disease. We propose further research be conducted into the effects of levodopa and dopamine agonists in depression with psychomotor retardation. Alternative neuroimaging methods such as PET sequences with shorter imaging protocols and neuromelanin-MRI should also be explored.
A Prospective 1-Year Study of Renal Recovery in Pigment Nephropathy: Insights Beyond the Acute Phase.
Pigment nephropathy is an underrecognized cause of acute kidney injury. Data from northern India is scarce. The present study aims to assess the clinical characteristics and outcomes of pigment nephropathy in this region. We analyzed the demographics, etiology, and outcomes of 20 patients with biopsy-proven pigment nephropathy. The mean age was 27.75 years (range: 13-52), with a male-to-female ratio of 18:2. The average peak serum creatinine was 12.09 mg/dL (range: 0.84-22.3). Rhabdomyolysis was identified in 14 (70%) and hemolysis in 6 patients (30%). The rhabdomyolysis was attributed to hypokalemia, infection, strenuous exercise, physical trauma, inflammatory myositis, neuroleptic malignant syndrome, and heat stroke. The hemolysis was caused by paroxysmal nocturnal hemoglobinuria, thrombotic microangiopathy, transfusion reaction, rifampicin, and physical stress. The majority of patients (85%) required hemodialysis, with a mean of 6 sessions (range: 3-17). The mean duration of hospitalization was 15.3 days (range: 4-30), and the average time to renal recovery was 3.1 weeks (range: 2-6). All 20 patients survived and achieved complete renal recovery. Of the 20 patients, 13 completed at least 1 year of follow-up, 4 were lost to follow-up, and 3 remain under observation. At 1 year, all 13 patients had normal serum creatinine. None progressed to chronic kidney disease. Of 20 patients (4.1%) with pigment-induced acute kidney injury (AKI), 70% had myoglobin- and 30% hemoglobin-induced nephropathy. Common causes included hypokalemia, infection, strenuous activity, and paroxysmal nocturnal hemoglobinuria. Hemodialysis was required in 85%, with an average hospital stay of 15.3 days. Among 13 patients with a 1-year follow-up, none developed chronic kidney disease. Overall prognosis appears favorable; however, larger studies with extended follow-up are needed to better characterize long-term outcomes in pigment nephropathy.
Effectiveness of Transdermal Blonanserin Patch for Hyperactive Delirium in Patients with Advanced Cancer Receiving Palliative Care.
Delirium affects most patients with advanced cancer and is a major source of distress, especially in its hyperactive subtype. Pharmacologic options are limited for patients who cannot take oral medications. To evaluate the effectiveness and safety of a transdermal blonanserin patch for managing hyperactive delirium in patients with advanced cancer admitted to a palliative care unit. Retrospective observational study. Consecutive patients with advanced cancer admitted to a palliative care unit in Japan between July 2023 and July 2025. Among 60 patients exhibiting agitation (Richmond Agitation-Sedation Scale-Palliative Version [RASS-PAL] ≥ +1), 21 received a 40-mg blonanserin patch. Eighteen patients who completed the 7-day assessment were analyzed. The primary endpoint was the change in RASS-PAL score from day 0 to day 7. Safety events and the need for additional antipsychotics were recorded. The median RASS-PAL score decreased from 2.0 to 0.5, and the mean score decreased from 1.9 to 0.6 (p = 0.0019). One patient developed reversible excessive sedation. No extrapyramidal symptoms, neuroleptic malignant syndrome, or cardiopulmonary events occurred. The median time from patch initiation to death was 24 days. Five patients required rescue antipsychotics, and no recurrence of the initial severity of delirium was observed. The transdermal blonanserin patch appears to be an effective and well-tolerated option for hyperactive delirium in patients with advanced cancer who cannot take oral antipsychotics. Larger prospective studies are warranted to confirm effectiveness and guide optimal use.
Case Report: Atypical neuroleptic malignant syndrome induced by paliperidone palmitate-diagnostic challenges and clinical considerations.
Poor treatment adherence is common in schizophrenia and constitutes a major risk factor for relapse and clinical instability. Long-acting injectable (LAI) antipsychotics are frequently prescribed to mitigate this risk; however, their use can be associated with rare but serious adverse events, including neuroleptic malignant syndrome (NMS), with certain atypical presentations posing considerable diagnostic challenges. We report the case of a 51-year-old patient with schizophrenia who, during hospitalization for a psychotic relapse following prolonged refusal of all oral medications, received an intramuscular injection of paliperidone palmitate. Within a few days, the patient experienced a rapid clinical deterioration, characterized by hyperthermia (38 °C), tachycardia (120 bpm), generalized muscular rigidity, mutism, confusion, dehydration, and refusal of oral intake. No obvious precipitating factors, including infectious or environmental triggers, were identified. Initial laboratory workup revealed marked creatine phosphokinase elevation (1700 U/L), hyperferritinemia, and evidence of a pulmonary infiltrate on chest imaging. Given this constellation of clinical and laboratory findings, a diagnosis of neuroleptic malignant syndrome (NMS) was considered. The lack of improvement with antibiotic therapy alone, the persistence of extrapyramidal symptoms, and the ongoing laboratory abnormalities supported the diagnosis of an atypical form of NMS. The patient was transferred to the intensive care unit, where symptomatic management-including intravenous rehydration, antipyretics, empirical antibiotic therapy, and diazepam-resulted in gradual clinical improvement. Complete recovery was achieved after five weeks of hospitalization. Antipsychotic therapy was cautiously reintroduced with olanzapine, which was well tolerated and not associated with any recurrence of symptoms. This case illustrates the diagnostic and therapeutic challenges of neuroleptic malignant syndrome associated with long-acting injectable antipsychotics and emphasizes the need for close and prolonged monitoring in patients receiving these formulations.
Publicações recentes
Atypical neuroleptic malignant syndrome without hyperthermia or rigidity in the ıntensive care unit: a diagnostic challenge.
Clozapine Withdrawal-Induced Catatonia with Overlapping Features of Neuroleptic Malignant Syndrome: a Case Report.
Malignant Catatonia and Neuroleptic Malignant Syndrome Overlap in the Emergency Department: Diagnostic Challenges and Psychopharmacology Considerations.
A Prospective 1-Year Study of Renal Recovery in Pigment Nephropathy: Insights Beyond the Acute Phase.
A case report of persistent cerebellar dysfunction following acute lithium toxicity.
📚 EuropePMC1.993 artigos no totalmostrando 198
Malignant Catatonia and Neuroleptic Malignant Syndrome Overlap in the Emergency Department: Diagnostic Challenges and Psychopharmacology Considerations.
Journal of clinical psychopharmacologyA Prospective 1-Year Study of Renal Recovery in Pigment Nephropathy: Insights Beyond the Acute Phase.
The Journal of the Association of Physicians of IndiaLong-term safety evaluation of mirtazapine: A real-world pharmacovigilance study based on the FAERS database.
PloS oneEffectiveness of Transdermal Blonanserin Patch for Hyperactive Delirium in Patients with Advanced Cancer Receiving Palliative Care.
Journal of palliative medicineCase Report: Atypical neuroleptic malignant syndrome induced by paliperidone palmitate-diagnostic challenges and clinical considerations.
Frontiers in psychiatryIntensive Care Management and Outcomes of Neuroleptic Malignant Syndrome: A Single-Center Retrospective Study.
Medicina (Kaunas, Lithuania)Neuroleptic Malignant Syndrome Induced by Multiple Antipsychotics in a Patient Receiving Methadone.
CureusPromethazine-induced neuroleptic malignant syndrome under general anesthesia: a case report.
Frontiers in psychiatrySertraline and quetiapine induced Serotonin Syndrome and Neuroleptic Malignant Syndrome: a case report.
BMC psychiatryUltrabrief and Brief Pulse Right Unilateral Electroconvulsive Therapy for Catatonia Management and Relapse Prevention: Naturalistic Case Series.
The journal of ECTClinical Outcomes of Dantrolene in Neuroleptic Malignant Syndrome: A Nationwide Retrospective Study.
Acta psychiatrica ScandinavicaCo-occurrence of Neuroleptic Malignant Syndrome and Silent Syndrome in a Patient With Bipolar Disorder: Clinical Challenges and Long-term Neurological Sequelae.
Cerebellum (London, England)Parkinsonism Exacerbation due to Acute Dopamine Depletion: A Conundrum Revisited.
Movement disorders clinical practiceNeurological Adverse Effects of Antipsychotic Medication in Children and Young People.
Paediatric drugsClinical Outcomes and Factors Associated with Neuroleptic Malignant Syndrome in Older Patients: A Case Control Study.
Journal of clinical medicineNeuroleptic Malignant Syndrome Unmasked: A Case of Extrapyramidal Syndrome With Tardive Dystonia Leading to a Life-Threatening Crisis.
CureusSerotonin Syndrome Versus Neuroleptic Malignant Syndrome in a Pediatric Patient Receiving Fluoxetine and Haloperidol: A Case Report.
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAGSystematic analysis of adverse reactions associated with dantrolene treatment: From clinical features to molecular mechanisms.
MedicineNeuroleptic Malignant Syndrome on Chronic Trifluoperazine Therapy: A Diagnostic Dilemma.
Clinical case reportsFrom Varenicline to Neuroleptic Malignant Syndrome: The Complex Effects of Smoking Cessation on Dopamine Regulation.
The primary care companion for CNS disordersLetter: Low CK, High Suspicion: A Case of Atypical Neuroleptic Malignant Syndrome in a Pediatric Post-Transplant Patient.
Journal of child and adolescent psychopharmacologyOlanzapine-Induced Diabetic Ketoacidosis and Neuroleptic Malignant Syndrome: A Case Report.
CureusSerotonin syndrome: understanding pathophysiological bases and managing a growing clinical challenge.
Neurologia i neurochirurgia polska[Experience of Neuroleptic Malignant Syndrome After Operation:Total Arch Replacement for Stanford Type A Acute Aortic Dissection:Report of a Case].
Kyobu geka. The Japanese journal of thoracic surgeryDantrolene use across surgical and medical care at Mayo Clinic from 2010 to 2024: Indications, frequency, and value for identifying malignant hyperthermia.
Biomolecules & biomedicineLorazepam in Managing Atypical Neuroleptic Malignant Syndrome: A Systematic Review of Case Reports.
The western journal of emergency medicineA Diagnostic Dilemma-Severe Hyperthermia and Rigidity in a Young Man with Polysubstance Use: A Case Report.
Clinical practice and cases in emergency medicineAnesthetic implications of psychotropic medications: a narrative review.
Journal of Yeungnam medical scienceNeurological Emergencies in Incarcerated Patients: Clinical Characteristics, Severity, and Outcomes in an Emergency Department with an Embedded Neuro-Emergency Expert Model.
Brain sciencesDevelopment of Neuroleptic Malignant Syndrome After Administration of Clozapine and Electroconvulsive Therapy in a Patient With Schizophrenia.
The primary care companion for CNS disordersBeyond Infections: A Case Report on the Identification of Neuroleptic Malignant Syndrome (NMS) in a Complex Clinical Context.
Clinical case reportsNeuroleptic Malignant Syndrome: A Case Report of the Oldest Man in Literature.
Clinical case reportsNeuroleptic Malignant Syndrome with Low-dose Quetiapine After Venlafaxine Withdrawal: A Case Report.
Turk psikiyatri dergisi = Turkish journal of psychiatryNeuroleptic malignant syndrome and clozapine withdrawal-induced catatonia: a case report.
East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kanA Real-World Pharmacovigilance study of FAERS Database for Fluvoxamine: Perspectives from Physicians and Pharmacists.
Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Three Episodes of Neuroleptic Malignant Syndrome With Risperidone: A Case Report and Literature Review.
Case reports in psychiatryReduced striatal dopamine transmission as a transdiagnostic substrate of psychomotor retardation.
Brain : a journal of neurologyTrauma-induced Catatonia in Pediatric Patients: Case Series and Literature Review.
Journal of child & adolescent traumaProbable Autoimmune Encephalitis Presenting With Catatonia in a Young Woman: A Case Report and Review of the Literature.
International journal of psychiatry in medicineThree Distinct Neuropsychiatric Syndromes Following Pineal Teratoma Resection.
Journal of child and adolescent psychopharmacologyA Narrative Review on Toxidromes in the Psychiatric Population: Implications for Overdose Prevention.
Journal of clinical medicineDealing with the dilemma of an encounter with neuroleptic malignant syndrome in an adolescent with mania: A case report.
Indian journal of psychiatryNeuroleptic Malignant Syndrome in an Institutionalized Geriatric Patient Following Antipsychotic Switch to Quetiapine: A Fatal Outcome.
CureusEmergency Treatment of Neuroleptic Malignant Syndrome By a Remote Mobile Electroconvulsive Therapy (ECT) Team.
The journal of ECTConcurrence of clozapine-induced diabetic ketoacidosis and neuroleptic malignant syndrome: A case report.
MedicineCatatonia in a Possible Case of Moderate Neuroleptic Malignant Syndrome: A Case Report.
Reports (MDPI)A Fatal Case of Recurrent Neuroleptic Malignant Syndrome Without Hyperthermia With the Use of Second-Generation Antipsychotics.
Journal of clinical psychopharmacologyA case of anti-N-methyl-D-aspartate receptor encephalitis with associated ovarian teratoma in a 23-year-old female.
Radiology case reportsAn unusual case of neuroleptic malignant syndrome.
Tropical doctorAn Analytic Review of Neuropsychiatric Syndromes in the Intensive Care Unit.
Journal of intensive care medicineAtypical Neuroleptic Malignant Syndrome Without Rigidity and With Cardiac Troponin Elevation.
Journal of the Academy of Consultation-Liaison PsychiatryA practical approach to managing agitated toxidromes.
Tropical doctorAnti-N-Methyl-D-Aspartate Receptor Encephalitis Presenting as Isolated First-Episode Psychosis in A 16-Year-Old Girl, Complicated by Neuroleptic Malignant Syndrome.
European journal of case reports in internal medicineSevere Catatonia in Early-Onset Schizophrenia Successfully Treated With Lorazepam and Aripiprazole in a 16-Year-Old Girl: A Case Report.
CureusA Young Man with Altered Mental Status, Rigidity, and Hyperthermia.
The NeurohospitalistNeuroleptic Malignant Syndrome: A Retrospective Chart Review from a Tertiary Neuropsychiatric Facility.
Neurology IndiaPost-marketing safety analysis of blonanserin: a retrospective pharmacovigilance study using the Japanese adverse drug event report database (2008-2024).
European journal of pharmacologyIs Abrupt Withdrawal of Benzodiazepines a Risk Factor for Neuroleptic Malignant Syndrome? A Case Report With Single-Dose Haloperidol.
Clinical case reportsSuccessful treatment with lithium carbonate for periodic psychosis of adolescence.
PCN reports : psychiatry and clinical neurosciencesNeuroleptic malignant syndrome: A case report.
JPMA. The Journal of the Pakistan Medical AssociationLetter: Seventeen-Year-Old Develops Neuroleptic Malignant Syndrome after Brief Low-Dose Exposure to Aripiprazole: A Case Report.
Journal of child and adolescent psychopharmacologyCase Report: Neuroleptic malignant syndrome in a 15-year-old female following of psychotropic drugs.
Frontiers in psychiatry[Fahr's disease and mania: case report and literature review].
Tijdschrift voor psychiatrieNeuroleptic malignant syndrome in a patient with COVID-19 and the possible role of SARS-CoV-2 in its manifestation: case report and overview of published cases.
BMC psychiatryAcute Febrile Encephalopathy with Rigidity.
Journal of intensive care medicineNeuroleptic Malignant Syndrome Following Brexpiprazole Initiation in a Treatment-Resistant Schizophrenia Patient With Influenza A: A Case Report.
CureusInvestigation into neuroleptic malignant syndrome triggered by atypical antipsychotics: Insights from FDA adverse event reporting system database.
Journal of affective disordersDiagnostic Value of Botryoid Nuclei as a Biomarker of Severe Hyperthermia and Systemic Inflammation in Heatstroke and Neuroleptic Malignant Syndrome: A Challenge of Climate Change.
International journal of laboratory hematologyCatatonia: American Psychiatric Association Resource Document.
Journal of the Academy of Consultation-Liaison PsychiatryAlcohol-Induced Neuroleptic Malignant Syndrome Complicated by Severe Acute Rhabdomyolysis.
CureusBenzodiazepine and Opioid Withdrawal Induced Neuroleptic Malignant Like Syndrome: A Clinical Case Report With Management Complexities.
Neuropsychopharmacology reportsAutoimmune psychosis: Psychopathological patterns and outcome after immunotherapy.
Schizophrenia researchNeuroleptic malignant syndrome requiring intensive care unit admission in two patients with SARS-CoV-2 infection in Portugal.
Acute and critical careNeuroleptic malignant syndrome induced by donepezil in a patient treated with risperidone and trazodone.
BMJ case reportsRhabdomyolysis and Acute Kidney Injury: Exploring the Potential Causes in a Hospitalized Patient.
CureusReversible Splenial Lesion Syndrome Induced by Paracetamol and Lithium: A Report of Two Cases and Literature Review.
CureusHypothermia and fluctuations in body temperature should be considered for the positive diagnosis of Neuroleptic Malignant Syndrome.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological PsychiatryMisdiagnosis and high-dose polypharmacy-induced neuroleptic malignant syndrome: a case report.
East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kanParkinsonism Hyperpyrexia Syndrome: A Rare Cause of Temperature Elevation.
CureusPaliperidone-induced neuroleptic malignant syndrome: A case report.
MedicineA case of modified electroconvulsive therapy for a patient with dementia with Lewy bodies and neuroleptic malignant syndrome.
Psychogeriatrics : the official journal of the Japanese Psychogeriatric SocietySecond-Generation Antipsychotic-Associated Serious Adverse Events in Women: An Analysis of a National Pharmacoepidemiologic Database.
Journal of clinical psychopharmacologyPaliperidone-Induced Massive Asymptomatic Creatine Kinase Elevation in Youth: From a Case Report to Literature Review.
Pediatric reportsRaised Creatine Kinase with Numerous Antipsychotics Responded to Clozapine.
Psychopharmacology bulletinIncreased incidence of akinetic crises in Parkinson's disease patients treated with Levodopa-Carbidopa Intestinal Gel: A case series and review of the literature.
Clinical neurology and neurosurgeryGenomic exploration of pediatric neurological disorders: a case series.
Journal of medical case reportsCOVID-19 and Neuroleptic Malignant Syndrome: A Case Report and Review of Literature.
Journal of clinical psychopharmacologyA Case of Euglycemic Ketoacidosis Secondary to Continuous Renal Replacement Therapy.
Case reports in critical careA case report of exacerbation of extrapyramidal symptoms following the switch from risperidone to paliperidone during valproate therapy.
BMC psychiatryContemporary Perspectives in Critical Care of Neuroleptic Malignant Syndrome.
Neurocritical careBromocriptine for Residual Catatonia Following Neuroleptic Malignant Syndrome: Illustrative Case Report and Systematic Review.
Journal of the Academy of Consultation-Liaison PsychiatryBilingual side effect: a case of foreign language syndrome following chlorpromazine-induced neuroleptic malignant syndrome.
Annals of general psychiatryA real-world pharmacovigilance study of neuroleptic malignant syndrome based on FDA adverse event reporting system.
Frontiers in pharmacologyThe limited clinical utility of a routine creatine kinase (CK) on admission to a psychiatric inpatient unit.
BMC psychiatryDiagnostic Challenges in Malignant Hyperthermia and Anesthesia-Induced Rhabdomyolysis: A Case Study.
The American journal of case reportsInflammation-Related Non-Infectious Febrile Reaction Induced by Electroconvulsive Therapy in a Young Female with Bipolar Disorder: A Case Report and Literature Review.
Psychiatry and clinical psychopharmacologyEvaluating the adverse drug reactions to clozapine in populations of children and adolescents: insights from VigiBase data.
European child & adolescent psychiatryLamotrigine as a preventive agent against recurrent catatonia in adult-onset Niemann-Pick Type-C disease: a case report.
NeurocaseSignal mining and risk analysis of olanzapine adverse events in the FAERS database.
Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)The broad spectrum of malignant syndromes.
Neurobiology of diseaseNeuroleptic Malignant Syndrome in a 10-Month-Old Ex-Preterm Infant with Delirium.
AJP reportsAnti-NMDAR Encephalitis developing neuroleptic malignant syndrome.
Industrial psychiatry journalUse of Electroconvulsive Therapy on an Adolescent Inpatient Psychiatric Unit.
Child and adolescent psychiatric clinics of North AmericaNeuroleptic malignant syndrome in Huntington disease.
European journal of neurologyBipolar Disorder in a Young Adult With Thalassemia Major With Sequential Development of Neuroleptic Malignant Syndrome and Serotonin Syndrome.
Journal of clinical psychopharmacologyExpert guidance on the differential diagnosis of neuroleptic malignant syndrome.
Expert review of neurotherapeuticsAcute kidney injury induced lithium toxicity with concomitant neuroleptic malignant syndrome.
BioMedicineA Case of Neuroleptic Malignant Syndrome-Prompted Myoglobin Cast Nephropathy.
Indian journal of nephrologyPsychiatric Etiologies and Approaches in Altered Mental Status Presentations: Insights from Consultation Liaison Psychiatry.
Seminars in neurologyEvaluation of Antipsychotic-Induced Neuroleptic Malignant Syndrome Using a Self-Organizing Map.
CureusRhythmic Delta Activity beyond Neuroleptic Malignant Syndrome.
Internal medicine (Tokyo, Japan)Long-Acting Injectable Antipsychotic Medication Use in Youth: A Systematic Review of the Literature Along with MedWatch Safety Data and Prescriber Attitudes.
Journal of child and adolescent psychopharmacologyNeuroleptic Malignant Syndrome.
The New England journal of medicineDual Toxidrome of Anti-cholinergic Storm and Neuroleptic Malignant Syndrome: A Therapeutic Challenge Overcome by Intrathecal Neostigmine.
The NeurohospitalistIncidence of Neuroleptic Malignant Syndrome During Antipsychotic Treatment in Children and Youth: A National Cohort Study.
Journal of child and adolescent psychopharmacologyNot Too Rare to Matter: The Incidence of Neuroleptic Malignant Syndrome in Children and Adolescents Treated with Antipsychotics.
Journal of child and adolescent psychopharmacologyWidespread Muscle Calcification due to Neuroleptic Malignant Syndrome.
Internal medicine (Tokyo, Japan)Life-threatening Neuroleptic Malignant Syndrome and Its Mechanism.
Internal medicine (Tokyo, Japan)Conceptualizing the relationship between synthetic cannabinoid use and neuroleptic malignant syndrome.
Bipolar disordersA Series of Eight Cases of Pigment Nephropathy: An Obscured Aspect of Acute Kidney Injury.
CureusThe Atypical Face of Neuroleptic Malignant Syndrome: A Case Report of Ileus and Absent Rigidity.
CureusInfectious disease evaluations in a psychiatric unit, an observational study.
Revista medica de ChileAtypical Presentation of Ziprasidone-Induced Neuroleptic Malignant Syndrome: A Case Report.
Journal of investigative medicine high impact case reportsIntegrating Physiotherapy in Neuroleptic Malignant Syndrome Management: A Case Report.
CureusCatatonia: A Narrative Review for Hospitalists.
American journal of medicine openConcomitant Administration of Ozanimod and Serotonergic Antidepressants in Patients With Ulcerative Colitis or Relapsing Multiple Sclerosis.
Inflammatory bowel diseasesSuccessful Diagnosis of Neuroleptic Malignant Syndrome in an Unconscious Patient Using Amplitude-Integrated Electroencephalography: A Case Report.
CureusUse of En-Bloc Multiple Monitored Electroconvulsive Therapy in Benzodiazepine Refractory Malignant Catatonia.
The journal of ECTRecurrent Fevers, Dysautonomia, and Dehydration in a Patient With Lesch-Nyhan Syndrome.
CureusNeuroleptic malignant syndrome following clozapine withdrawal.
Industrial psychiatry journalCaution for psychiatrists: malignant hyperthermia risks with the anesthetic agent succinylcholine (Suxamethonium) during electroconvulsive therapy.
BMC psychiatryLong prodromal symptoms of neuroleptic malignant syndrome in patient with intellectual developmental disorder-A case report.
Neuropsychopharmacology reportsSuccessful Treatment of Both Refractory Neuroleptic Malignant Syndrome and Subsequent Catatonia With Electroconvulsive Therapy in a Patient With Suspected Kufs Disease.
The journal of ECTNeuroleptic malignant syndrome and serotonin syndrome: a comparative bibliometric analysis.
Orphanet journal of rare diseasesReintroduction of Clozapine following Neuroleptic Malignant Syndrome in a Young Patient with Resistant Schizophrenia.
Case reports in psychiatryHaloperidol-Induced Neuroleptic Malignant Syndrome: A Case Report.
CureusSerious adverse drug events associated with psychotropic treatment of bipolar or schizoaffective disorder: a 17-year follow-up on the LiSIE retrospective cohort study.
Frontiers in psychiatryAripiprazole-induced quasi-neuroleptic malignant syndrome: two case reports.
Journal of medical case reportsNeuroleptic Malignant Syndrome: An Intensive Care Unit Case of Exceptionally High Creatinine Kinase and Myoglobin Levels.
CureusProchlorperazine-induced neuroleptic malignant syndrome.
The American journal of emergency medicineNeuroleptic malignant syndrome after overdose of haloperidol - A case report.
Toxicology reportsTransient Fever Response After ECT in a Patient with Catatonic Schizophrenia: A Case Report.
Turk psikiyatri dergisi = Turkish journal of psychiatryNeuroleptic Malignant Syndrome Concurrent with COVID-19 Infection: A Case Report.
Turk psikiyatri dergisi = Turkish journal of psychiatryMixed Connective Tissue Disease Presenting With Psychosis-A Case Report.
The Journal of nervous and mental diseaseAn Evidence-Based Update on Anticholinergic Use for Drug-Induced Movement Disorders.
CNS drugsParkinsonism-hyperpyrexia, a rare consequence of deep brain stimulator malfunction in advanced Parkinson's disease.
Clinical parkinsonism & related disordersNeuroleptic malignant syndrome after abrupt discontinuation of neuroleptic and anticholinergic drugs.
Industrial psychiatry journalAtypical Neuroleptic Malignant Syndrome With Type 2 Respiratory Failure Treated With Non-invasive Ventilation.
CureusAtypical neuroleptic malignant syndrome in an incarcerated patient: a demographic who may be at increased risk.
BMJ case reportsFirst generation antipsychotic-associated serious adverse events in women: a retrospective analysis of a pharmacovigilance database.
International journal of clinical pharmacySerotonin syndrome and neuroleptic malignant syndrome: A case report of intersecting symptomatology.
The mental health clinicianCatatonia-related adverse outcomes after long-acting injectable antipsychotics: Case series.
SAGE open medical case reportsHold off That Olanzapine! The Development of Neuroleptic Malignant Syndrome in a Dehydrated Pediatric Patient.
Kansas journal of medicineAnesthesia Management for Electroconvulsive Therapy.
AANA journalParkinsonism-Hyperpyrexia Syndrome in a patient undergoing upper gastrointestinal surgery: A case report.
Qatar medical journalSubthalamic Deep Brain Stimulation in Parkinson's Disease: A Boon or Bane - A Single Centre Retrospective Observational Study from India.
Asian journal of neurosurgeryExamining the Features of Neuroleptic Malignant Syndrome in Anti-NMDA Receptor Encephalitis: A Case-Control Study.
Journal of the Academy of Consultation-Liaison PsychiatryConcurrent administration of serotonergic antidepressants and ozanimod in participants with relapsing multiple sclerosis from the open-label extension DAYBREAK trial.
Multiple sclerosis (Houndmills, Basingstoke, England)Postoperative rhabdomyolysis due to neuroleptic malignant syndrome associated with droperidol and metoclopramide.
Anaesthesiology intensive therapyWhen the fever will not stop, stop the pills! A case report.
Sao Paulo medical journal = Revista paulista de medicinaEvaluation of neuroleptic malignant syndrome induced by antipsychotic drugs using spontaneous reporting system.
HeliyonSevere Recurrence of Neuroleptic Malignant Syndrome: Usefulness of Dexmedetomidine for Antipsychotic Withdrawal.
CureusChallenges in the Clinical Diagnosis of Lithium Toxicity: A Case Report.
CureusATYPICAL NEUROLEPTIC MALIGNANT SYNDROME ASSOCIATED WITH MIRTAZAPINE USE.
Psychiatria DanubinaNeuroleptic Malignant Syndrome in Patients With Dementia: Experiences of A Single Memory Clinic.
Clinical neuropharmacologyNeuroleptic Malignant Syndrome Associated With Lurasidone: A Case Report.
Journal of clinical psychopharmacologyElectrolyte Disturbances Related to Sodium and Potassium and Electroconvulsive Therapy: A Systematic Review.
Journal of clinical medicineThe role of antipsychotics and other drugs on the development and progression of neuroleptic malignant syndrome.
Scientific reportsSerotonin syndrome caused by a CYP2C19-mediated interaction between low-dose escitalopram and clopidogrel: a case report.
Frontiers in psychiatryA Case of Neuroleptic Malignant Syndrome in the Context of Lithium Toxicity and Aripiprazole Use.
Clinical neuropharmacologyNeuroleptic Malignant Syndrome with Underlying Catatonia - a Case Report.
Psychiatria DanubinaMalignant Tourette's Syndrome in an Adult on Deep Brain Stimulation Presenting With Rhabdomyolysis.
CureusElevated Creatine Phosphokinase in a Patient on a Long-Acting Antipsychotic: A Challenging Presentation Similar to Neuroleptic Malignant Syndrome.
The primary care companion for CNS disordersFunctional propriospinal myoclonus in neuroleptic malignant syndrome.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical NeurophysiologyAn Unusual Presentation of Serotonin Syndrome and Subsequent Catatonia in a Patient With a Family History of Huntington's Disease.
CureusNeuroleptic Malignant Syndrome After Lithium Withdrawal.
Journal of clinical psychopharmacologyNeuroleptic Malignant Syndrome in a 15-Month-Old Child: A Case Report.
Journal of clinical psychopharmacologyManagement of a trauma patient with alcohol withdrawal who developed neuroleptic malignant syndrome in Korea: a case report.
Journal of trauma and injuryA Rare Case of Malignant Syndrome in Parkinson's Disease Caused by Severe Dehydration and Complicated by Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH).
CureusWhat clinical analysis of antipsychotic-induced catatonia and neuroleptic malignant syndrome tells us about the links between these two syndromes: A systematic review.
Schizophrenia researchCOVID-19 Pandemic-Delayed Diagnosis and Treatment of Atypical Neuroleptic Malignant Syndrome in a Violent Forensics Patient With Intellectual Disability and Treatment-Resistant Schizophrenia.
CureusMalignant psoas syndrome and bilateral hydronephrosis without evident obstruction in colorectal cancer.
BMJ case reportsThe diagnostic dilemma in a patient with neuroleptic malignant syndrome during the COVID-19 pandemic: A significant increase in acute phase reactants.
Clinical case reportsPharmacological Considerations of Neuroleptic Malignant Syndrome in a Patient on a Long-Acting Antipsychotic.
Journal of the Academy of Consultation-Liaison PsychiatryRebound Catatonia Associated With Injectable Paliperidone.
CureusNon-Psychosis Symptoms of Clozapine Withdrawal: a Systematic Review.
East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kanLoxapine in the Treatment of Manic and Psychotic Symptoms in an Individual Intolerant to Multiple Mood-Stabilizing and Antipsychotic Medications.
Case reports in psychiatrySerotonin Syndrome: The Role of Pharmacology in Understanding Its Occurrence.
Cureus[Central anticholinergic, neuroleptic malignant and serotonin syndromes].
Wiener klinisches Magazin : Beilage zur Wiener klinischen WochenschriftThe diagnosis and treatment of catatonia.
Clinical medicine (London, England)Adolescent Aripiprazole-Associated Rhabdomyolysis Without Neuroleptic Malignant Syndrome: A Case Report.
Journal of clinical psychopharmacologyNeuroleptic Malignant Syndrome Improved with Intramuscular Administration of the Anticholinergic Agent, Biperiden.
International medical case reports journalAn Unusual Cause of Persistent Tachycardia: Atypical Neuroleptic Malignant Syndrome.
CureusAn Atypical Case of Neuroleptic Malignant Syndrome Associated With Ciprofloxacin and Quetiapine.
CureusEvidence-based consensus guidelines for the management of catatonia: Recommendations from the British Association for Psychopharmacology.
Journal of psychopharmacology (Oxford, England)A Case of Neuroleptic Malignant Syndrome Presenting as Anxiety.
CureusRapid symptom control in neuroleptic malignant syndrome with electroconvulsive therapy: A case report.
Frontiers in psychiatryNeuroleptic malignant syndrome induced by aripiprazole depot.
NeurologiaAssociações
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Long-term safety evaluation of mirtazapine: A real-world pharmacovigilance study based on the FAERS database.
- Reduced striatal dopamine transmission as a transdiagnostic substrate of psychomotor retardation.
- A Prospective 1-Year Study of Renal Recovery in Pigment Nephropathy: Insights Beyond the Acute Phase.
- Effectiveness of Transdermal Blonanserin Patch for Hyperactive Delirium in Patients with Advanced Cancer Receiving Palliative Care.
- Case Report: Atypical neuroleptic malignant syndrome induced by paliperidone palmitate-diagnostic challenges and clinical considerations.
- Atypical neuroleptic malignant syndrome without hyperthermia or rigidity in the ıntensive care unit: a diagnostic challenge.
- Clozapine Withdrawal-Induced Catatonia with Overlapping Features of Neuroleptic Malignant Syndrome: a Case Report.
- Malignant Catatonia and Neuroleptic Malignant Syndrome Overlap in the Emergency Department: Diagnostic Challenges and Psychopharmacology Considerations.
- A case report of persistent cerebellar dysfunction following acute lithium toxicity.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:94093(Orphanet)
- MONDO:0019790(MONDO)
- GARD:7195(GARD (NIH))
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
- Q1424956(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
