Raras
Buscar doenças, sintomas, genes...
Tumor tímico
ORPHA:100100DOENÇA RARA

Neoplasia que afeta o timo. Exemplos representativos incluem timoma e carcinoma.

Mantido por Agente Raras·Colaborar como especialista →

Introdução

O que você precisa saber de cara

📋

Neoplasia que afeta o timo. Exemplos representativos incluem timoma e carcinoma.

Pesquisas ativas
6 ensaios
156 total registrados no ClinicalTrials.gov
Publicações científicas
350 artigos
Último publicado: 2026 Apr 10
🏥
SUS: Sem cobertura SUSScore: 0%
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Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

📏
Crescimento
6 sintomas
🩸
Sangue
6 sintomas
🫁
Pulmão
5 sintomas
🫘
Rins
3 sintomas
💪
Músculos
3 sintomas
🛡️
Imunológico
2 sintomas

+ 35 sintomas em outras categorias

Características mais comuns

Neoplasia da pleura
Adenoma de células nulas hipofisárias
Hipercalcemia
Som respiratório anormal
Hiperidrose
Edema
65sintomas
Sem dados (65)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 65 características clínicas mais associadas, ordenadas por frequência.

Neoplasia da pleuraNeoplasia of the pleura
Adenoma de células nulas hipofisáriasPituitary null cell adenoma
HipercalcemiaHypercalcemia
Som respiratório anormalAbnormal breath sound
HiperidroseHyperhidrosis

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico350PubMed
Últimos 10 anos152publicações
Pico202121 papers
Linha do tempo
2026Hoje · 2026🧪 1998Primeiro ensaio clínico📈 2021Ano de pico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

Genes associados

2 genes identificados com associação a esta condição.

BCL6B-cell lymphoma 6 proteinCandidate gene tested inAltamente restrito
FUNÇÃO

Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional

LOCALIZAÇÃO

Nucleus

VIAS BIOLÓGICAS (3)
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertainFOXO-mediated transcription of cell death genesInterleukin-4 and Interleukin-13 signaling
OUTRAS DOENÇAS (4)
follicular lymphomaprimary mediastinal large B-cell lymphomaintravascular large B-cell lymphomahigh grade B-cell lymphoma with MYC and/ or BCL2 and/or BCL6 rearrangement
HGNC:1001UniProt:P41182
XPO1Exportin-1Candidate gene tested inAltamente restrito
FUNÇÃO

Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP

LOCALIZAÇÃO

CytoplasmNucleus, nucleoplasmNucleus, Cajal bodyNucleus, nucleolus

VIAS BIOLÓGICAS (10)
Cyclin A/B1/B2 associated events during G2/M transitionNPAS4 regulates expression of target genesMaturation of hRSV A proteinsDownregulation of TGF-beta receptor signalingNEP/NS2 Interacts with the Cellular Export Machinery
EXPRESSÃO TECIDUAL(Ubíquo)
Linfócitos
99.4 TPM
Fibroblastos
81.4 TPM
Ovário
63.8 TPM
Útero
59.2 TPM
Cervix Endocervix
58.9 TPM
OUTRAS DOENÇAS (1)
primary mediastinal large B-cell lymphoma
HGNC:12825UniProt:O14980

Variantes genéticas (ClinVar)

110 variantes patogênicas registradas no ClinVar.

🧬 BCL6: GRCh37/hg19 3q22.1-29(chr3:132561657-197851986)x3 ()
🧬 BCL6: NM_001706.5(BCL6):c.384-200A>C ()
🧬 BCL6: NM_001706.5(BCL6):c.1812C>T (p.Cys604=) ()
🧬 BCL6: NM_001706.5(BCL6):c.1977+41T>G ()
🧬 BCL6: GRCh37/hg19 3q26.31-29(chr3:174764228-197851986)x3 ()
Ver todas no ClinVar

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

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Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
2Fase 23
·Pré-clínico3
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 6 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Tumor tímico

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

🟢 Recrutando agora

4 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

Outros ensaios clínicos

156 ensaios clínicos encontrados, 6 ativos.

Distribuição por fase
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
156 papers (10 anos)
#1

Brief Report: Androgen Receptor Expression Is Associated With Male Predominance in Thymic Neuroendocrine Neoplasms.

JTO clinical and research reports2026 Apr

Neuroendocrine neoplasms represent a rare and poorly understood collection of malignancies. A better understanding of their biology is needed to improve treatment options. Male predominance to the incidence of neuroendocrine neoplasms of the thymus suggests a biological basis for this observation. This single-institution, retrospective cohort study evaluated androgen receptor (AR) expression and other clinicopathologic features in thymic neuroendocrine neoplasms compared with thymic epithelial tumors and neuroendocrine neoplasms of other sites. Expression of neuroendocrine and prostate markers was also assessed. For further molecular characterization, copy number analysis of AR and other relevant genes was assessed by single nucleotide polymorphism array. Last, analysis of single genes and thymic epithelial gene sets was performed using published thymic tumor transcriptomes. A cohort was assembled from 17 patients with neuroendocrine malignancies of primary thymic origin with assessable tissue for immunohistochemical analysis. The cohort was predominantly male (12 males, five females). Immunohistochemical analysis of the AR demonstrated positive staining in nine cases, all of which were male. Compared with thymic neuroendocrine neoplasms, AR expression is considerably less frequent in thymomas, thymic carcinoma, and neuroendocrine neoplasms of other sites of origin. No relevant copy number changes in the AR were identified. Further molecular characterization revealed expression of ASCL1 and limited expression of common prostate lineage and differentiation markers within our cohort, including thymic neuroendocrine epithelial gene set enrichment in published transcriptomes of thymic neuroendocrine neoplasms. The AR is expressed in a considerable fraction of thymic neuroendocrine neoplasms and is associated with male predominance. This observation has implications for investigation of androgen deprivation and receptor blockade.

#2

Dose and normal tissue complication probability analysis of various radiotherapy regimens for thymomas.

Frontiers in oncology2026

This study aimed to compare dosimetric differences and normal tissue complication probability (NTCP) among coplanar intensity-modulated radiation therapy (CO-IMRT), non-coplanar IMRT (NONCO-IMRT), coplanar volumetric-modulated arc therapy (CO-VMAT), and non-coplanar VMAT (NONCO-VMAT) in thymoma radiotherapy and clarify the value of non-coplanar plans. Forty-eight post-thymoma surgery patients were enrolled in this study. Four radiotherapy plans (50 Gy/25 fractions) were made for each patient. The target conformity index (CI), homogeneity index (HI), and organ-at-risk (OAR) (lungs, heart, etc.) dose parameters were then evaluated. NTCP was calculated using the Lyman-Kutcher-Burman (LKB) model. Statistical analysis was performed using the Student-Newman-Keuls (SNK-q) test (p < 0.05 for significance). There were no significant clinical differences in target volume coverage and homogeneity among the four plans. The lung V20, heart V30, spinal cord Dmax, and esophagus Dmax of the VMAT techniques were all lower than those of IMRT (p < 0.001). The breast dose of CO-VMAT was significantly higher, while the breast parameters of NONCO-VMAT were close to those of IMRT. NTCP results were consistent with dosimetric findings: VMAT plans had lower NTCP for the heart, spinal cord, and esophagus; moreover, the breast NTCP of CO-VMAT was significantly increased (1.75%), while that of NONCO-VMAT decreased to 0.28%, which was similar to that of IMRT. All four plans meet the thymoma target dose requirement. However, NONCO-VMAT is preferred for its advantages in multi-organ protection and balanced breast dose. Additionally, CO-VMAT should be used cautiously in female patients due to the higher breast dose.

#3

Impact of the COVID-19 pandemic on thoracic surgery volume in Japan: an analysis of the National Clinical Database.

Surgery today2026 Apr

The COVID-19 pandemic has disrupted elective surgeries worldwide. This study evaluated the impact of the pandemic on thoracic surgery volumes in Japan and investigated real-world triage practices by thoracic surgeons. Using Japan's National Clinical Database, we analyzed both annual and quarterly trends in surgical procedures and patient characteristics of lung and thymic tumors from 2019 to 2023. Compared to 2019, surgeries for primary lung cancer, thymic tumors, and spontaneous pneumothorax declined in 2020, with the most pronounced decreases occurring in Q2 during Japan's first state of emergency. Specifically, the numbers declined by 8.7%, 9.7%, and 27.1%, respectively. The greatest decline in pathological (p-) stage 0-IA1 lung cancer cases occurred in Q2 2020 (- 22% vs. Q2 2019), while reductions in more advanced stages during Q2 remained below 10%, with peak decreases observed in Q3. By 2023, the number of p-Stage II-IV cases had decreased, while the number of IA1-IB cases had increased. Thymoma and thymic cysts declined in Q2 2020 (- 4.4%, - 35.1%, respectively), but thymic cancer remained stable. Notably, thymic tumor size showed no temporal change throughout the study period. Despite strategic triage by thoracic surgeons during the initial phase of the pandemic, the overall disease profile of thoracic malignancies remained largely unaffected by treatment delays through 2023 in Japan. (200 words).

#4

Catheter-directed thrombectomy combined with angioplasty and stent implantation for superior vena cava syndrome: a case report.

Translational cancer research2025 Dec 31

Superior vena cava (SVC) syndrome (SVCS) caused by thrombosis in artificial vascular grafts is characterized by high morbidity and mortality, with endovascular treatment being the primary therapeutic approach. In this case report, we present a safe multimodal endovascular treatment protocol that can rapidly alleviate acute SVCS symptoms, combining targeted thrombectomy via a guiding catheter with balloon dilation and Bard venous stent placement. Such combined endovascular therapies remain relatively uncommon in clinical reports. A 61-year-old female with a 10-year history of mediastinal nodules was admitted to hospital for recurrent dizziness. Via computed tomography (CT), she was diagnosed with a malignant thymic tumor invading the SVC and subsequently underwent sternotomy via a video-assisted thoracoscopic approach for tumor resection and SVC reconstruction with an 8-mm expanded polytetrafluoroethylene (e-PTFE) graft. Postoperatively, she developed SVCS (upper extremity/chest wall swelling, cyanosis) due to graft occlusion. Emergency treatment included 8F guiding catheter thrombectomy, sequential balloon dilatation, and Bard venous stenting, which resolved the stenosis. She received anticoagulants (low-molecular-weight heparin and subsequent rivaroxaban) and had no thrombosis at follow-up in August 2024. The combination of guiding catheter thrombectomy, balloon dilatation, and Bard stent implantation is feasible, safe, and effective for e-PTFE graft-associated SVCS, relieving symptoms quickly and avoiding reoperation. This approach can benefit patients unsuited to surgery, but they should be monitored closely for adverse hemodynamic events after stenting. Further studies are needed to validate the efficacy of this method.

#5

Comparative analysis of the tumor immune microenvironment between thymoma and thymic carcinoma.

Lung cancer (Amsterdam, Netherlands)2025 Nov

Thymic epithelial tumors (TETs) often linked with autoimmune syndromes such as myasthenia gravis (MG), have an underexplored tumor immune microenvironment (TIME), limiting the effective use of Immune Checkpoint Inhibitors. This study aims to address the immunology of TETs, focusing on the prognostic significance of TIME and its association with MG. This study investigates the TIME in TET subtypes, thymic carcinoma (TC) and thymoma, assesses their prognoses, and examines the relationship between thymoma's immune microenvironment and MG. This study included 157 patients with TET who underwent surgical resection at Juntendo Hospital between January 2012 and September 2020. Immune cell densities of tissue specimens were analyzed using multiplex fluorescence immunohistochemical staining. Thymoma and TC were diagnosed in 145 and 12 patients, respectively. Thymoma types B1 and B2 showed elevated CD4+ and CD8+ T cells, while TC had decreased T cells and increased Foxp3+ T cells. Thymoma with MG had higher CD20+CD79a- cells counts in the stromal area compared to those without MG (p = 0.0165). Elevated CD4+ T cells (p = 0.0310), CD8+ T cells (p = 0.0215), and CD68+ cells (p = 0.0432) in the tumor area were linked to good prognosis, while higher CD20+CD79a- cells in the stromal area indicated poor prognosis (p = 0.0088). Thymomas had a higher prevalence of T cells compared to TC. CD4+ T cells, CD8+ T cells, and CD68+ cells in the tumor area were favorable prognostic markers, while B cells in the stromal area indicated a poor prognosis for thymoma.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC82 artigos no totalmostrando 152

2026

Brief Report: Androgen Receptor Expression Is Associated With Male Predominance in Thymic Neuroendocrine Neoplasms.

JTO clinical and research reports
2026

Dose and normal tissue complication probability analysis of various radiotherapy regimens for thymomas.

Frontiers in oncology
2025

Catheter-directed thrombectomy combined with angioplasty and stent implantation for superior vena cava syndrome: a case report.

Translational cancer research
2026

Impact of the COVID-19 pandemic on thoracic surgery volume in Japan: an analysis of the National Clinical Database.

Surgery today
2025

Comparative analysis of the tumor immune microenvironment between thymoma and thymic carcinoma.

Lung cancer (Amsterdam, Netherlands)
2025

A Case of Breast Cancer Recurrence Mimicking a Thymus Tumor With Vascular Invasion.

Cureus
2025

Intraoperative diaphragmatic plication during initial surgery with phrenic nerve resection.

Interdisciplinary cardiovascular and thoracic surgery
2025

Thymolipoma as a Rare Cause of Myasthenia Gravis.

Neuro-ophthalmology (Aeolus Press)
2025

Relapse of Cyclic Cushing Syndrome With a 19-Year Remission: Potential Involvement of COVID-19 in the Relapse.

JCEM case reports
2025

Surgical Expert Consensus on Clinical Management of Advanced Thymoma and Thymic Carcinoma: A Beijing-Tianjin-Hebei Collaborative Initiative.

Thoracic cancer
2025

[Cholesterol Granuloma Arising in the Thymus:Report of a Case].

Kyobu geka. The Japanese journal of thoracic surgery
2025

A Phase II Clinical Trial of Neoadjuvant Concurrent Chemoradiotherapy for Locally Advanced High-Grade Thymic Tumors.

JTO clinical and research reports
2025

Metastasectomy in Thymic and Germ Cell Tumors.

Thoracic surgery clinics
2025

Treatment of thymoma with low-dose glucocorticoids before surgery for significant tumor shrinkage: A case report.

World journal of clinical cases
2025

Rapid growing mass of the mandible due to an oral metastasis of thymoma: Case report of an extremely rare localization and review of published cases.

Heliyon
2025

Multilocular thymic cysts- a diagnostic challenge on computed tomography.

World journal of clinical cases
2024

Causal Relationship Between Physical Activity and Thymic Tumors Mediated by Circulating Cytokines: A Mendelian Randomization Mediation Analysis.

International journal of molecular sciences
2024

Clinical application of standardization right thoracic incision for thoracoscopic thymic tumor resection.

Journal of cardiothoracic surgery
2024

Primary thymic enteric-type adenocarcinoma: A rare thymic tumor.

Asian journal of surgery
2025

Prevalence of restless legs and association with patient-reported outcome measures in myasthenia gravis.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
2024

Abnormal Cellular Populations Shape Thymic Epithelial Tumor Heterogeneity and Anti-Tumor by Blocking Metabolic Interactions in Organoids.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
2024

Thymic epithelial tumor medical treatment: A narrative review.

Biochimica et biophysica acta. Reviews on cancer
2024

Case report: Potential role of immunotherapy in thymic malignancies: a unique case of a durable and complete response upon an immune checkpoint inhibitor.

Frontiers in immunology
2024

Avoiding misdiagnosis of multilocular thymic cysts as malignant tumors on computer tomography.

World journal of clinical cases
2024

Case report: A challenging case of severe Cushing's syndrome in the course of metastatic thymic neuroendocrine carcinoma with a synchronous adrenal tumor.

Frontiers in endocrinology
2024

Hide-and-Seek With Spindle-Cell-Component-Poor Metaplastic Thymoma.

Cureus
2025

Robotic surgery for thymic cysts: clinical features, management, and results of a multicentric study.

Updates in surgery
2024

A basaloid carcinoma with multilocular thymic cyst mimicking a mediastinal teratoma.

Journal of cardiothoracic surgery
2024

Multilocular thymic cysts can be easily misdiagnosed as malignant tumor on computer tomography: A case report.

World journal of clinical cases
2024

Comparison of radiotherapy techniques in patients with thymic epithelial tumor who underwent postoperative radiotherapy.

Radiation oncology journal
2023

A case report of dermatomyositis mimicking myasthenia gravis.

Medicine
2023

Modified subxiphoid thoracoscopic thymectomy for early-stage thymic tumor: case report.

Mediastinum (Hong Kong, China)
2023

[Clinicopathological and molecular features of metaplastic thymoma].

Zhonghua bing li xue za zhi = Chinese journal of pathology
2023

A Rare Case of Mediastinal Mass: Thymoma and Thymic Tumor.

Cureus
2023

[Video-assisted Thoracoscopic Surgery for Mediastinal Tumor and Thoracic Wall Tumor].

Kyobu geka. The Japanese journal of thoracic surgery
2023

Lipofibroadenoma and other rare thymic tumors: a call for misfits.

Mediastinum (Hong Kong, China)
2023

Potential activity of adiponectin-expressing regulatory T cells against triple-negative breast cancer cells through the cell-in-cell phenomenon.

Thoracic cancer
2023

Surgical resection of micronodular thymic carcinoma with lymphoid hyperplasia: a case report.

General thoracic and cardiovascular surgery cases
2023

[Thymic Neuroendocrine Tumor Associated with Multiple Endocrine Neoplasia Type 1].

Kyobu geka. The Japanese journal of thoracic surgery
2023

Invasive thymoma metastases to the pancreas: A case report.

International journal of surgery case reports
2023

Understanding the landscape of immunotherapy in thymic epithelial tumors.

Cancer
2022

The role of surgery in advanced thymic tumors: A retrospective cohort study.

Frontiers in oncology
2023

Gene fusions are frequent in ACTH-secreting neuroendocrine neoplasms of the pancreas, but not in their non-pancreatic counterparts.

Virchows Archiv : an international journal of pathology
2023

Thymic lipofibroadenomas: Three case reports.

World journal of clinical cases
2023

Minimally Invasive Thymectomy Could Be Attempted for Locally Advanced Thymic Malignancies: A Real-World Study With Propensity Score-Matched Analysis.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
2023

Adiponectin-expressing Treg cells in experimental thymic tumor model.

Thoracic cancer
2023

Experimental model of micronodular thymic neoplasm with lymphoid stroma.

Thoracic cancer
2022

Severe cardiotoxicity in 2 patients with thymoma receiving immune checkpoint inhibitor therapy: A case report.

Medicine
2022

Thymic lipofibroadenoma of the anterior mediastinum: A rare case report.

Medicine
2022

LCK-Mediated RIPK3 Activation Controls Double-Positive Thymocyte Proliferation and Restrains Thymic Lymphoma by Regulating the PP2A-ERK Axis.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
2022

Postoperative radiotherapy for thymus salivary gland carcinoma: A case report.

World journal of clinical cases
2022

Systematic detection of mosaicism by using digital NGS reveals three new MEN1 mosaicisms.

Endocrine connections
2022

Micronodular thymoma with lymphoid stroma: Contrast-enhanced CT features with histopathological correlation in 10 patients.

Frontiers in oncology
2022

Early Detection of Relapse by ctDNA Sequencing in a Patient with Metastatic Thymic Tumor and MEN1 Mosaicism.

The Journal of clinical endocrinology and metabolism
2022

Thymoma (World Health Organization Type AB) in multiple endocrine neoplasia type 1: a case report.

Journal of surgical case reports
2022

Ectopic adrenocorticotrophic hormone syndrome initially presenting as abnormal mental behavior caused by thymic carcinoid: a case report.

Gland surgery
2022

Management of incidentally detected small anterior mediastinal nodules: Which way to go?

Lung cancer (Amsterdam, Netherlands)
2021

Thymolipoma and its Association with Myasthenia Gravis: a Multi-center Experience.

Medical archives (Sarajevo, Bosnia and Herzegovina)
2021

A spectrum of Thymic mucosa-associated lymphoid tissue lymphoma and Thymic amyloidosis in the patient with Auto immune disease: a case series.

Mediastinum (Hong Kong, China)
2021

Autogenous pericardial angioplasty for thymic malignancies: a narrative review.

Mediastinum (Hong Kong, China)
2021

Thymic tumours: a single center surgical experience and literature review on the current diagnosis and management of thymic malignancies.

Gland surgery
2021

Surgical management of locally invasive basaloid carcinoma of thymic gland.

Journal of surgical case reports
2021

Occult pleural dissemination detected intraoperatively in patients with thymic tumors: a retrospective analysis.

Journal of cardiothoracic surgery
2021

Cushing's Syndrome Due to a Functional Thymic Neuroendocrine Tumor in Multiple Endocrine Neoplasia Type 1 Syndrome.

Cureus
2021

A Rare Thymic Tumor - Lipofibroadenoma - Always a Postoperative Surprise.

In vivo (Athens, Greece)
2021

Evaluation of Surgical Therapy in Advanced Thymic Tumors.

Cancers
2021

Viral infection in thymoma and thymic tumors with autoimmune diseases.

Thoracic cancer
2021

Two distinct classes of thymic tumors in patients with MEN1 show LOH at the MEN1 locus.

Endocrine-related cancer
2021

Tumor immunity is related to 18 F-FDG uptake in thymic epithelial tumor.

Cancer medicine
2021

Development of thymic tumor in [LSL:KrasG12D; Pdx1-CRE] mice, an adverse effect associated with accelerated pancreatic carcinogenesis.

Scientific reports
2021

Vascular Involvement in Thymic Epithelial Tumors: Surgical and Oncological Outcomes.

Cancers
2021

Dual-scopic robotic thymectomy for a large thymic malignant tumor.

Journal of surgical case reports
2021

[Chinese guideline for clinical diagnosis and treatment of thymic epithelial tumors (2021 Edition)].

Zhonghua zhong liu za zhi [Chinese journal of oncology]
2022

The Early Perioperative Outcomes of Subxiphoid Approach Versus Lateral Intercostal Approach Thoracoscopic Thymectomy for Thymic Tumors: A Meta-Analysis.

Journal of laparoendoscopic &amp; advanced surgical techniques. Part A
2021

SS-A52 antigen expression in thymic carcinoma accompanied with Sjögren syndrome: A case report.

Medicine
2020

How to obtain adequate biopsy specımen in suspected thymic tumors.

Journal of thoracic disease
2020

[Analysis of Gene Variation in Thymoma by Microarray].

Zhongguo fei ai za zhi = Chinese journal of lung cancer
2020

[Histopathological and molecular characteristics of metaplastic thymomas: report of five cases].

Zhonghua bing li xue za zhi = Chinese journal of pathology
2021

Thymic Metastasis of Ovarian Cancer 33 Years After Primary Surgery.

The Annals of thoracic surgery
2020

Case Series: A case of familial thymomatous myasthenia gravis in a family of three male brothers.

Journal of surgical case reports
2021

Subxiphoid dual-port thymectomy for thymoma in a patient with post-aortic left brachiocephalic vein.

General thoracic and cardiovascular surgery
2020

A case of thymic basaloid carcinoma with rectal carcinoma.

International journal of surgery case reports
2021

Comparison of Subxiphoid and Intercostal Uniportal Thoracoscopic Thymectomy for Nonmyasthenic Early-Stage Thymoma: A Retrospective Single-Center Propensity-Score Matching Analysis.

The Thoracic and cardiovascular surgeon
2020

Total superior vena cava reconstruction guided by preoperative three-dimensional (3D)-computed tomography bronchography and angiography.

Translational cancer research
2020

Tumor-associated myeloid cells provide critical support for T-ALL.

Blood
2020

Thymolipoma Association with Myasthenia Gravis: Case Report.

The American journal of case reports
2020

Case Report-Secondary Antibody Deficiency Due to Endogenous Hypercortisolism.

Frontiers in immunology
2020

Venous thromboembolism after adult thymus or thymic tumor resection: A single-center experience.

Thoracic cancer
2020

Successful treatment of combined thymic epithelial tumor with hepatic metastasis: a long disease-free survival case.

General thoracic and cardiovascular surgery
2020

Induction therapy followed by surgery for advanced thymic tumors.

Asian journal of surgery
2021

Prosthetic Reconstruction of Superior Vena Cava System for Thymic Tumor: A Retrospective Analysis of 22 Cases.

The Thoracic and cardiovascular surgeon
2019

Micronodular thymic tumor with lymphoid stroma: A case report and review of the literature.

World journal of clinical cases
2019

Robotic-assisted simultaneous resection of a left-sided thymic neoplasm and a right-sided lower thoracic paravertebral neoplasm via the same ports and two docking steps: a case report.

Journal of cardiothoracic surgery
2019

Clinical Heterogeneity in Patients with Glutamate Decarboxylase Antibody.

Neuroimmunomodulation
2019

[A Case of Primary Thymic Carcinoid Treated with Everolimus and Octreotide].

Gan to kagaku ryoho. Cancer &amp; chemotherapy
2019

Video-assisted thoracoscopy versus open approach in patients with Masaoka stage III thymic epithelial tumors.

Translational cancer research
2019

Pathological discrepancies in the diagnosis of thymic epithelial tumors: the Tallinn-Lyon experience.

Journal of thoracic disease
2019

Microscopic polyangiitis associated with thymic tumor: a case report and review of the literature.

BMC nephrology
2019

Thymic papillary adenocarcinoma coexisting with type A thymoma: A case report.

International journal of surgery case reports
2019

Immunoglobulin G4 Thymic Tumor.

The Annals of thoracic surgery
2019

Distinguishing between Thymic Epithelial Tumors and Benign Cysts via Computed Tomography.

Korean journal of radiology
2019

Increased Galectin-1 Expression in Thymic Epithelial Tumors.

Clinical lung cancer
2018

Thymoma dissemination through the thoracic intervertebral foramen: Pleural recurrence resulting in spinal cord compression.

Surgical neurology international
2020

Metastatic Potential and Survival of Duodenal and Pancreatic Tumors in Multiple Endocrine Neoplasia Type 1: A GTE and AFCE Cohort Study (Groupe d'étude des Tumeurs Endocrines and Association Francophone de Chirurgie Endocrinienne).

Annals of surgery
2018

Thymoma with an isolated splenic metastasis eight years after extended thymectomy: a case report.

BMC cancer
2018

Anti-TIF1γ antibody predicted malignancy of thymic tumor with dermatomyositis as an "autoimmune tumor marker": A case report.

Medicine
2018

Iodine Quantification Using Dual-Energy Computed Tomography for Differentiating Thymic Tumors.

Journal of computer assisted tomography
2019

Elective Nodal Irradiation as Adjuvant Radiotherapy for Advanced Thymomas and Thymic Carcinomas.

Clinical lung cancer
2018

Lipofibroadenoma with B1 thymoma: A case report of a rare thymic tumor.

Indian journal of pathology &amp; microbiology
2019

Primary Thymic Signet Ring Cell Adenocarcinoma: A Currently Unrecognized Variant.

International journal of surgical pathology
2018

Non-intubated thoracoscopic surgery: initial experience at a single center.

Journal of thoracic disease
2019

Metastatic thymic tumor arising from spermatic cord leiomyosarcoma.

General thoracic and cardiovascular surgery
2018

Thymic tumors and immune checkpoint inhibitors.

Journal of thoracic disease
2018

A Thymic Hyperplasia Case without Suppressing on Chemical Shift Magnetic Resonance Imaging.

Case reports in radiology
2018

Robot-assisted thymectomy via subxiphoid approach: technical details and early outcomes.

Journal of thoracic disease
2018

Clinical implication of MEN1 mutation in surgically resected thymic carcinoid patients.

Journal of thoracic disease
2018

Concurrent thymic carcinoma and middle lobe syndrome.

Journal of thoracic disease
2018

Optimal surgical approach to thymic malignancies: New trends challenging old dogmas.

Lung cancer (Amsterdam, Netherlands)
2017

Dedifferentiated primary mediastinal liposarcoma mimicking a thymic tumor.

Pathologica
2018

A case of madness resulting in a fortunate outcome; case report of a psychotic break as a result of cortisol secreting thymic neuroendocrine thymic tumor.

Journal of community hospital internal medicine perspectives
2018

MSA Mimic? Rare Occurrence of Anti-Hu Autonomic Failure and Thymoma in a Patient with Parkinsonism: Case Report and Literature Review.

Frontiers in neuroscience
2018

[Clinical Study on the Prognosis of Patients with Thymoma with Myasthenia Gravis].

Zhongguo fei ai za zhi = Chinese journal of lung cancer
2017

Epstein-Barr virus in tumor-infiltrating B cells of myasthenia gravis thymoma: an innocent bystander or an autoimmunity mediator?

Oncotarget
2017

KRAS mutation-positive mucinous adenocarcinoma originating in the thymus.

Journal of thoracic disease
2018

Thymic enteric type adenocarcinoma: A case report with cytological features.

Diagnostic cytopathology
2017

Clinical and pathological aspects of microscopic thymoma with myasthenia gravis and review of published reports.

Journal of thoracic disease
2017

Malignant thymoma with metastasis associated with paraneoplastic myasthenia gravis.

Proceedings (Baylor University. Medical Center)
2017

Surgery of Thymic Tumor with Persistent Left Superior Vena Cava.

Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
2017

Superior vena cava reconstruction under the left internal jugular vein to left femoral vein bypass support.

Perfusion
2017

Efficacy of computed tomography features in predicting stage III thymic tumors.

Oncology letters
2016

[Post-allogeneic stem cell transplant extramedullary relapse of acute megakaryoblastic leukemia initially detected by elevated WT1 mRNA levels in peripheral blood].

[Rinsho ketsueki] The Japanese journal of clinical hematology
2016

Definitive IMRT for Stage III Thymic Carcinoma: A Brief Report and Literature Review.

Frontiers in oncology
2016

Thymic Tumor Extension into the Heart, a Rare Finding Found by Point-of-Care Ultrasound.

Cureus
2016

Occasional detection of thymic epithelial tumor 4 years after diagnosis of adult onset Still disease: A challenging case report and immuno-oncological considerations coming from pertinent literature review.

Medicine
2016

Postoperative radiotherapy and tumor recurrence after complete resection of stage II/III thymic tumor: a meta-analysis of cohort studies.

OncoTargets and therapy
2016

[Role of Postoperative Radiotherapy for Stage I/II/III Thymic Tumor - Results of the ChART Retrospective Database].

Zhongguo fei ai za zhi = Chinese journal of lung cancer
2017

Two surgical cases of thymic MALT lymphoma associated with multiple lung cysts: possible association with Sjögren's syndrome.

General thoracic and cardiovascular surgery
2016

Outcome of nonsurgical treatment for locally advanced thymic tumors.

Journal of thoracic disease
2016

The role of postoperative radiotherapy for stage I/II/III thymic tumor-results of the ChART retrospective database.

Journal of thoracic disease
2016

Single Institution Experience of Thymic Tumor Treatment and Survival in Egypt.

Asian Pacific journal of cancer prevention : APJCP
2016

Development of combined thymic carcinoma and thymoma in an extrathymic lesion during long follow-up for recurrent thymoma.

Molecular and clinical oncology
2016

Endogenous dendritic cells from the tumor microenvironment support T-ALL growth via IGF1R activation.

Proceedings of the National Academy of Sciences of the United States of America
2016

A 73-year-old woman with persistent diarrhea and onychomycosis.

Allergy and asthma proceedings
2016

Morvan Syndrome: A Case Report With Patient Narrative and Video.

The Neurohospitalist
2016

Thymic Small Cell Neuroendocrine Carcinoma Displayed on 18F-FDG PET/CT Imaging.

Clinical nuclear medicine
2015

Cytoplasm estrogen receptor β5 as an improved prognostic factor in thymoma and thymic carcinoma progression.

Oncology letters
2015

Good syndrome presenting with CD8⁺ T-Cell large granular lymphocyte leukemia.

Oncotarget
2015

Thymectomy and transpericardial nodal dissection.

Thoracic cancer
2015

Impact of VEGF, VEGFR, PDGFR, HIF and ERCC1 gene polymorphisms on thymic malignancies outcome after thymectomy.

Oncotarget
2015

Thymic Tumor With Adenoid Cystic Carcinoma-Like Features: A Study of a Clinically Favorable Case Followed for 9 Years.

International journal of surgical pathology
2015

Paraneoplastic Neurological Syndromes and Glutamic Acid Decarboxylase Antibodies.

JAMA neurology
2015

GLI1, CTNNB1 and NOTCH1 protein expression in a thymic epithelial malignancy tissue microarray.

Anticancer research

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Doenças relacionadas

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Brief Report: Androgen Receptor Expression Is Associated With Male Predominance in Thymic Neuroendocrine Neoplasms.
    JTO clinical and research reports· 2026· PMID 41847153mais citado
  2. Dose and normal tissue complication probability analysis of various radiotherapy regimens for thymomas.
    Frontiers in oncology· 2026· PMID 41727665mais citado
  3. Impact of the COVID-19 pandemic on thoracic surgery volume in Japan: an analysis of the National Clinical Database.
    Surgery today· 2026· PMID 41143979mais citado
  4. Catheter-directed thrombectomy combined with angioplasty and stent implantation for superior vena cava syndrome: a case report.
    Translational cancer research· 2025· PMID 41510110mais citado
  5. Comparative analysis of the tumor immune microenvironment between thymoma and thymic carcinoma.
    Lung cancer (Amsterdam, Netherlands)· 2025· PMID 41072251mais citado
  6. Challenges and Controversies in the Diagnosis and Management of Thymic Epithelial Tumors from the Thymic Tumor Subcommittee of the International Association for the Study of Lung Cancer Rare Tumors Committee.
    J Thorac Oncol· 2026· PMID 41961041recente
  7. Elucidating the binding and metabolic interactions of sunitinib and sorafenib with Cytochrome P450s CYP2U1 and CYP2D6.
    Mol Pharmacol· 2026· PMID 41946119recente
  8. Two Surgical Cases of Thymic Tumor Requiring Resection and Reconstruction of the Superior Vena Cava and the Brachiocephalic Vein.
    Ann Vasc Dis· 2026· PMID 41924076recente
  9. Two novel multiple endocrine neoplasia type 1 variants caused thymic neuroendocrine tumor: a case report.
    Hered Cancer Clin Pract· 2026· PMID 41736142recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:100100(Orphanet)
  2. MONDO:0005197(MONDO)
  3. GARD:19767(GARD (NIH))
  4. Variantes catalogadas(ClinVar)
  5. Busca completa no PubMed(PubMed)
  6. Q53844926(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

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Tumor tímico

ORPHA:100100 · MONDO:0005197
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