A corioretinopatia Birdshot é uma inflamação na parte de trás do olho (uveíte posterior) que se caracteriza por várias manchas esbranquiçadas e mais claras (com pouca pigmentação) na coroide, uma camada no fundo do olho. Ela está fortemente ligada a um marcador genético chamado HLA-A29 e seus sintomas incluem visão embaçada, pontos ou manchas que flutuam na visão (moscas volantes), flashes de luz, pontos cegos e dificuldade para enxergar no escuro.
Introdução
O que você precisa saber de cara
A corioretinopatia Birdshot é uma inflamação na parte de trás do olho (uveíte posterior) que se caracteriza por várias manchas esbranquiçadas e mais claras (com pouca pigmentação) na coroide, uma camada no fundo do olho. Ela está fortemente ligada a um marcador genético chamado HLA-A29 e seus sintomas incluem visão embaçada, pontos ou manchas que flutuam na visão (moscas volantes), flashes de luz, pontos cegos e dificuldade para enxergar no escuro.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 10 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 28 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
1 gene identificado com associação a esta condição. Padrão de herança: Unknown.
Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-A-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:10449296, PubMed:12138174, PubMed:12393434, PubMed:1402688, PubMed:15893615, PubMed:17189421, PubMed:19543285
Cell membraneEndoplasmic reticulum membrane
Variantes genéticas (ClinVar)
23 variantes patogênicas registradas no ClinVar.
Vias biológicas (Reactome)
9 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Corio-retinopatia "birdshot"
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Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
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1 pesquisa recrutando participantes. Converse com seu médico sobre a possibilidade de participar.
Outros ensaios clínicos
5 ensaios clínicos encontrados, 1 ativos.
Publicações mais relevantes
The Impact of ERAP1 and ERAP2 Haplotype Combinations on Susceptibility and Severity of Birdshot Chorioretinitis.
To investigate how ERAP1 and ERAP2 genotype combinations influence susceptibility and severity in birdshot chorioretinitis (BSCR), an HLA-A29-associated disease with variable visual outcomes. We analyzed ERAP1 and ERAP2 haplotypes in 406 HLA-A29-positive BSCR patients and 106 HLA-A29-positive controls. ERAP1 activity was inferred from published enzymatic efficiency data and ERAP2 activity from protein expression data. Predicted peptide trimming activity was assigned to each patient. Correlation and multivariable regression analyses were performed to evaluate associations between ERAP1 and ERAP2 genotypes and disease severity, assessed by disease onset (age at first symptoms) and visual outcomes: best-corrected visual acuity, mean deviation, pattern standard deviation, and foveal threshold. We observed high genetic diversity, with 86 distinct ERAP1-ERAP2 genotype combinations among BSCR patients. The Hap10-Hap8 ERAP1 pairing was most frequent in BSCR (13.6%) and less common in controls (6.6%). The ERAP2 HapA-HapA genotype was more frequent in patients (33.7%) than in controls (19.8%). The mean estimated total peptide trimming activity of ERAP1 per individual was significantly lower in BSCR patients than in controls (adjusted P = 6.2e-07), whereas ERAP2 activity was higher (adjusted P = 0.0025). No robust associations between ERAP1 or ERAP2 activity and visual outcomes were detected. In multivariable models, visual outcomes were predominantly driven by age and disease duration. Our findings support a model in which ERAP1 and ERAP2 contribute to BSCR susceptibility, but have limited influence on disease severity. The observed pattern of reduced ERAP1 and elevated ERAP2 activity in BSCR patients may affect peptide processing and HLA-A29-mediated presentation.
NON-INFECTIOUS POSTERIOR UVEITIDES - Atypicals, Variants, and Masquerades: the jungle of differential diagnosis.
Non-infectious posterior and panuveitides (NIPUs) comprise a heterogeneous group of inflammatory disorders of the outer retina and choroid, historically referred to as "white dot syndromes." Recent consensus efforts by the Multimodal Imaging in Uveitis (MUV) Task Force have established standardized diagnostic criteria for the major NIPUs, including multiple evanescent white dot syndrome (MEWDS), multifocal choroiditis and panuveitis/punctate inner choroiditis (MFCPU/PIC), acute posterior multifocal placoid pigment epitheliopathy (APMPPE), serpiginous choroiditis, and birdshot chorioretinopathy (BSCR). Nevertheless, a substantial proportion of cases deviate from classical presentations and fall into diagnostic "grey zones", blurring boundaries between diseases entities and complicating both differential diagnosis and management. This review aims to describe the broad spectrum of atypical, variant, and secondary forms of NIPUs as well as masquerade syndromes. Atypical MEWDS includes bilateral presentations or complicated courses, while MFCPU/PIC with outer retinal atrophy emerges as a notable entity with unclear therapeutic implications. Inflammatory reactions resembling both MEWDS and MFCPU/PIC may also occur as secondary phenomena, triggered by other chorioretinal disorders, most notably inherited retinal diseases (IRDs). Placoid chorioretinopathies, including APMPPE, persistent placoid maculopathy, serpiginous choroiditis, and relentless placoid chorioretinitis, are often distinguished only a posteriori based on disease course, but likely represent a continuum of disorders unified by choroidal ischemia. Atypical presentations of BSCR may feature extensive outer retinal damage, mimicking IRDs. Equally important is the consideration of masquerade syndromes in all suspected cases of NIPUs, as they can present with similar features yet require entirely different treatments. Infectious masquerades include tuberculosis-associated serpiginous-like choroiditis, acute syphilitic posterior placoid chorioretinopathy, and West Nile virus chorioretinitis, whereas vitreoretinal lymphoma is the most frequent neoplastic masquerade. In conclusion, integrating clinical context with high-quality multimodal imaging remains essential to navigate the jungle of differential diagnosis in NIPUs, while future studies should aim to link imaging phenotypes with immune and molecular biomarkers to refine classification and guide targeted therapies.
Birdshot Chorioretinopathy with Cystoid Macular Oedema.
We report the case of a 48-year-old Caucasian male who presented with progressive bilateral visual decline over more than three months. He was diagnosed with birdshot chorioretinopathy (BSCR) according to the Standardization of Uveitis Nomenclature (SUN) criteria, based on characteristic fundus findings and HLA-A29 positivity. Laboratory investigations, including angiotensin-converting enzyme (ACE) and soluble IL-2 receptor levels, were within normal limits and infectious serologies were negative. Thoracic imaging by computed tomography showed no signs suggestive of sarcoidosis or infection, and pulmonary function testing was normal. Systemic corticosteroids combined with methotrexate improved vitritis but left cystoid macular edema (CME) largely unchanged, especially in the right eye. Therapy was therefore switched to mycophenolate mofetil and adalimumab, which produced a marked reduction of CME, although some cystic changes persisted. This case highlights the therapeutic challenges in the real-world management of BSCR complicated by persistent CME. Even with reduction of intraocular inflammation, CME may remain resistant to systemic corticosteroids alone, particularly in patients presenting late in the disease course. Early diagnosis, exclusion of systemic mimics, and a flexible, imaging-guided approach to treatment are essential for optimising visual prognosis.
Viral triggers and genetic predisposition in ocular autoimmunity: unraveling the breakdown of immune privilege and advancing targeted therapeutics.
The eye maintains vision through a distinctive immune privilege, utilizing physical barriers and active immunosuppression mediated by molecules such as FasL and PD-L1, as well as cells, including regulatory T cells and RPE cells. The emergence of sight-threatening immune-mediated ocular diseases, including non-infectious uveitis, signifies a significant disruption of this tolerance. This review analyzes the role of viral triggers and genetic predisposition in inducing immunological failure, while emphasizing the development of targeted therapeutic strategies. Viruses induce autoimmunity through molecular mimicry (Rotavirus peptides cross-reacting with retinal S-antigen), bystander activation, and active immune suppression (CMV inhibiting RPE cell IDO1 activity). HLA alleles, especially HLA-A29 (Birdshot Chorioretinopathy) and HLA-B27 (acute anterior uveitis), as well as non-MHC genes like NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome and AIRE, greatly increase the risk of genetic disorders. Treatment is progressing towards precision medicine, with targeted biologics like the IL-6 receptor inhibitor Tocilizumab being key strategies. Moreover, AAV-mediated gene therapy that expresses immunosuppressive molecules such as HLA-G demonstrates promise for the restoration of long-term tolerance in preclinical models, facilitating the development of advanced future strategies.
Sex-Related Effects on the Clinical Presentation of Uveitis.
The primary aim of this study was to determine sex-related patterns of uveitic entities. Secondary aims included sex-related patterns of uveitic complications. Retrospective clinical cohort study. 5703 participants presenting with uveitis from January 2009 to December 2023 were included. uveitis entities and complications. 2870 (50.3%) participants were female and 2831 (49.6%) were male. Males presented at a significantly younger age than females (42.2 vs 45.0). Significant sex-based differences were observed in the prevalence of specific uveitic conditions. Females were more likely to develop multifocal choroiditis (female: male ratio 1.818:1), Vogt-Koyanagi-Harada syndrome (female: male ratio 2.136:1), birdshot chorioretinopathy (female: male ratio 2.800:1, punctate inner choroidopathy (female: male ratio 6.571:1), drug-induced uveitis (female: male ratio 2.833:1), Crohn's disease (female: male ratio 3.714:1) and multiple evanescent white dot syndrome (female: male ratio 5.000:1). In contrast, males were more likely to develop acute posterior multifocal placoid pigment epitheliopathy (female: male ratio 0.364:1), sympathetic ophthalmia (female: male ratio 0.353:1) and syphilis (female: male ratio 0.404:1). Cataract was significantly more common in females, and this remained significant after adjusting for age at presentation, anatomical location and bilaterality. Cystoid macular edema and epiretinal membrane were more frequent in females, whereas retinal detachment occurred more often in males. Bilateral vision loss occurred in 238 patients (4.2%) and was significantly more common in females (4.9% vs 3.5%). Sex appears to be a key factor influencing the underlying etiology and clinical course of uveitis. These findings underscore the importance of considering sex as a biological variable in the diagnosis, monitoring, and management of uveitis.
Publicações recentes
Oral cyclophosphamide as part of the treatment regimen in patients with nonparaneoplastic autoimmune retinopathy secondary to birdshot chorioretinopathy.
💬 OpiniãoNoninfectious Posterior Uveitides - Atypicals, Variants, and Masquerades: The Jungle of Differential Diagnosis.
Birdshot Chorioretinopathy with Cystoid Macular Oedema.
Viral triggers and genetic predisposition in ocular autoimmunity: unraveling the breakdown of immune privilege and advancing targeted therapeutics.
Sex-Related Effects on the Clinical Presentation of Uveitis.
📖 Revisão📚 EuropePMC188 artigos no totalmostrando 196
NON-INFECTIOUS POSTERIOR UVEITIDES - Atypicals, Variants, and Masquerades: the jungle of differential diagnosis.
American journal of ophthalmologyBirdshot Chorioretinopathy with Cystoid Macular Oedema.
Klinische Monatsblatter fur AugenheilkundeViral triggers and genetic predisposition in ocular autoimmunity: unraveling the breakdown of immune privilege and advancing targeted therapeutics.
Molecular aspects of medicineSex-Related Effects on the Clinical Presentation of Uveitis.
American journal of ophthalmologyBirdshot Chorioretinopathy in a Patient of Filipino Ancestry: A Case Report.
CureusThe Impact of ERAP1 and ERAP2 Haplotype Combinations on Susceptibility and Severity of Birdshot Chorioretinitis.
Investigative ophthalmology & visual scienceIntriguing choroidal lesions in Birdshot chorioretinopathy: a diagnostic and clinical dilemma.
Journal of ophthalmic inflammation and infectionBirdshot Chorioretinopathy with Double-Layer Sign and Choroidal Neovascularization: A Single-Centre Analysis.
Ocular immunology and inflammationSuprachoroidal Triamcinolone Acetonide for the Treatment of Refractory Macular Edema Secondary to Non-Infectious Uveitis.
Research squareClinical utility of ultra-widefield indocyanine green angiography in posterior uveitis.
Journal francais d'ophtalmologieGuidelines From the French-Speaking Society for Histocompatibility and Immunogenetics (SFHI) for Harmonisation of HLA Genotyping in Autoimmune Diseases, Drug Hypersensitivity and Pharmacogenetics.
HLABirdshot Chorioretinopathy in a Patient on Tocilizumab for the Treatment of Giant Cell Arteritis.
Case reports in ophthalmological medicineThe relationship between retinal vascular tortuosity and retinal vasculitis.
Journal of ophthalmic inflammation and infectionBirdshot Chorioretinopathy Successfully Treated with Adalimumab: A Case Report.
Korean journal of ophthalmology : KJOEvaluation of Corticosteroids, Immunosuppressants and Biotherapies in Patients with Birdshot Retinochoroidopathy.
Ocular immunology and inflammationMinimum Imaging Sets for Diagnosis, Activity Assessment, and Complications in Noninfectious Posterior Uveitis - Multimodal Imaging in Uveitis (MUV) Task Force Report 9.
American journal of ophthalmologyNoninfectious Uveitis Syndromes.
Advances in experimental medicine and biologySuccessful Use of Upadacitinib, a Selective JAK Inhibitor, in the Treatment of Two Cases of Recalcitrant Chronic Uveitis.
Journal of ophthalmic & vision researchEvidence and Consensus-based Imaging Guidelines in Birdshot Chorioretinopathy: Multimodal Imaging in Uveitis (MUV) Taskforce Report 8.
American journal of ophthalmology[Changes in global ERG in Birdshot chorioretinopathy and correlation with central macular thickness on OCT].
Journal francais d'ophtalmologiePrognostic Factors of Treatment Failure with First-Line Corticosteroid-Sparing Agents in Patients with Birdshot Chorioretinopathy: A Retrospective Study.
Ocular immunology and inflammationRisankizumab-Rzaa in the Management of Birdshot Chorioretinopathy: A Case Report.
Ocular immunology and inflammationIntravitreal Corticosteroids in the Management of Refractory Macular Edema in Birdshot Chorioretinopathy.
International medical case reports journalElectroretinography of disease activity and treatment response in birdshot chorioretinopathy.
Eye (London, England)[BIRDSHOT CHORIORETINOPATHY].
HarefuahBILATERAL SEQUENTIAL INFLAMMATORY FULL-THICKNESS MACULAR HOLES IN BIRDSHOT CHORIORETINOPATHY.
Retinal cases & brief reportsRecurrent uveitic macular edema managed with intravitreal faricimab injection.
Journal of ophthalmic inflammation and infectionSystemic Lymphoma Masquerading as Birdshot Chorioretinopathy.
Retinal cases & brief reportsPeripapillary atrophy in patients with birdshot chorioretinitis.
The British journal of ophthalmologySpectrum of Imaging Characteristics of Birdshot Chorioretinopathy.
Ocular immunology and inflammationAn update of multimodal imaging in white dot syndrome.
Oman journal of ophthalmologyIndolent Nonprogressive Multifocal Choroidal Lesions: A Review of Literature and Case Report Based on Similarity.
Ocular immunology and inflammationThe Impact of HLA-A29 Homozygosity and of the Second HLA-A Allele on Susceptibility and Severity of Birdshot Chorioretinitis.
Investigative ophthalmology & visual scienceOnline Patient Resources for Birdshot Uveitis: How Readable are These Resources?
Ocular immunology and inflammationCYSTOID MACULAR EDEMA IN BIRDSHOT RETINOCHOROÏDITIS: Long-Term Treatment Study in 142 Patients.
Retina (Philadelphia, Pa.)Quality of Life in Patients with Birdshot Chorioretinitis Aged 80 and Older.
Ocular immunology and inflammationHLA-A29 Negative Birdshot-like Chorioretinopathy Associated with Vitiligo-Case Report.
Journal of clinical medicineCharacterization of Retinal Microvascular Abnormalities in Birdshot Chorioretinopathy Using OCT Angiography.
Ophthalmology scienceSingle-cell profiling identifies a CD8bright CD244bright Natural Killer cell subset that reflects disease activity in HLA-A29-positive birdshot chorioretinopathy.
Nature communicationsFractal Changes of the Retinal Microvasculature in Birdshot Chorioretinopathy.
Ophthalmic surgery, lasers & imaging retinaAssessment of Blood Flow Velocity in Retinal Vasculitis Using the Retinal Function Imager-A Pilot Study.
Journal of clinical medicineApplication of Ophthalmic Electrophysiology in Inflammatory Disorders of Retina and Optic Nerve.
Journal of clinical medicineVisual acuity and visual field as a function of disease duration in patients with birdshot chorioretinitis.
The British journal of ophthalmologyOptic Disc Edema Is an Under-Recognized Feature of Birdshot Chorioretinitis.
Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology SocietyINDOCYANINE GREEN ANGIOGRAPHY OF OPTIC DISK GRANULOMA IN OCULAR SARCOIDOSIS.
Retinal cases & brief reportsBirdshot Chorioretinopathy in Early Adulthood: Review of Current Literature and Case Report.
International medical case reports journalOptical coherence tomography angiography in birdshot chorioretinopathy.
European journal of ophthalmologyLong-Term Outcomes of Birdshot Chorioretinopathy Treated with Corticosteroids: A Case Reports.
Journal of clinical medicineNon-invasive biomarkers for close activity monitoring in birdshot chorioretinitis: Optical coherence tomography angiography and beyond.
Acta ophthalmologicaReactive lymphoid hyperplasia of the uvea in a patient with birdshot chorioretinopathy.
Canadian journal of ophthalmology. Journal canadien d'ophtalmologieAtypical Unilateral Birdshot Chorioretinitis in a Hispanic Female.
Puerto Rico health sciences journalHISTOPATHOLOGIC CONFIRMATION OF LYMPHOCYTIC INFILTRATION OF THE OPTIC NERVE AND INNER RETINA IN BIRDSHOT CHORIORETINOPATHY.
Retina (Philadelphia, Pa.)Birdshot Chorioretinitis in Patients Aged 80 and Older.
Ocular immunology and inflammationMultimodal Imaging of Choroidal Lesions in an Elderly Man With Uveal Lymphoid Hyperplasia.
Journal of vitreoretinal diseasesBirdshot chorioretinopathy mimicking chiasmal compression.
Canadian journal of ophthalmology. Journal canadien d'ophtalmologieSwept Source Optical Coherence Tomography Angiography Findings in Birdshot Chorioretinitis: A Cross Sectional Study of 21 Patients.
Ocular immunology and inflammationThe incidence, presenting clinical findings and treatment patterns of Birdshot Retinochoroiditis in a high-prevalence region: findings from Northern Ireland, England and Wales.
Eye (London, England)Birdshot chorioretinopathy in an HLA-A29 positive Asian patient.
American journal of ophthalmology case reportsRetina-arrestin specific CD8+ T cells are not implicated in HLA-A29-positive birdshot chorioretinitis.
Clinical immunology (Orlando, Fla.)High Positive Predictive Value of Fluorescein Angiography Contiguous, Perineural Retinal Vascular Leakage Pattern for Birdshot Chorioretinopathy.
Ocular immunology and inflammationLower fractal dimension of retinal vessel for patients with Birdshot chorioretinopathy.
Acta ophthalmologicaBenefits and Limitations of OCT-A in the Diagnosis and Follow-Up of Posterior Intraocular Inflammation in Current Clinical Practice: A Valuable Tool or a Deceiver?
Diagnostics (Basel, Switzerland)Evaluating patient-reported outcome measures (PROMs) for clinical trials and clinical practice in adult patients with uveitis or scleritis: a systematic review.
Journal of ophthalmic inflammation and infectionAcute macular neuroretinopathy in a patient with birdshot chorioretinopathy after intravitreal triamcinolone suspension injection.
European journal of ophthalmologySpectrally resolved autofluorescence imaging in posterior uveitis.
Scientific reportsBirdshot Chorioretinopathy: A Review.
Journal of clinical medicineA Case of Birdshot Chorioretinopathy following Varicella Zoster Virus-Induced Progressive Retinal Necrosis in the Contralateral Eye.
Case reports in ophthalmologyElectrophysiological Assessment in Birdshot Chorioretinopathy: Flicker Electroretinograms Recorded With a Handheld Device.
Translational vision science & technologyOuter Retinal Disruption in Early-Onset Birdshot Chorioretinopathy.
Ophthalmology. RetinaProgress in the genetics of uveitis.
Genes and immunityBirdshot Chorioretinopathy: Resistant versus Responsive.
Ocular immunology and inflammationTreatment Outcomes in Birdshot Chorioretinitis: Corticosteroid Sparing, Corticosteroid Discontinuation, Remission, and Relapse.
Ophthalmology. RetinaROLE OF OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN DETECTING AND MONITORING INFLAMMATORY CHOROIDAL NEOVASCULARIZATION.
Retina (Philadelphia, Pa.)Anti-Tumor Necrosis Factor α versus Tocilizumab in the Treatment of Refractory Uveitic Macular Edema: A Multicenter Study from the French Uveitis Network.
OphthalmologyNot All Cases of Visual Snows are Benign: Mimics of Visual Snow Syndrome.
Neuropsychiatric disease and treatmentERAP1, ERAP2, and Two Copies of HLA-Aw19 Alleles Increase the Risk for Birdshot Chorioretinopathy in HLA-A29 Carriers.
Investigative ophthalmology & visual scienceDoes the Interaction of KIR and HLA Affect the Development of Non-Infectious Uveitis?
Current molecular medicineLate recurrence in birdshot chorioretinopathy.
Canadian journal of ophthalmology. Journal canadien d'ophtalmologieIMMUNE-MEDIATED INTRAOCULAR INFLAMMATION. A REVIEW.
Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnostiBilateral juxtapapillary choroidal neovascularization secondary to Birdshot chorioretinopathy-case report.
Clinical case reportsOcular manifestations of skin diseases with pathological keratinization abnormalities.
Postepy dermatologii i alergologiiRecurrence of inflammatory choroidal lesions on indocyanine green angiography despite adalimumab treatment as monotherapy in two patients with birdshot retinochoroidopathy: Report of two cases.
Journal francais d'ophtalmologiePeripapillary Halo in Inflammatory Papillitis of Birdshot Chorioretinopathy.
Clinical ophthalmology (Auckland, N.Z.)Pathogenesis of Non-Infectious Uveitis Elucidated by Recent Genetic Findings.
Frontiers in immunologyAnalysis of peripheral inflammatory T cell subsets and their effector function in patients with Birdshot Retinochoroiditis.
Scientific reportsClassification Criteria for Birdshot Chorioretinitis.
American journal of ophthalmology[Anatomic-functional correlations in birdshot chorioretinopathy: An observational single-center prospective study].
Journal francais d'ophtalmologieElectroretinogram and Visual Field Correlation in Birdshot Chorioretinopathy.
Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)Infectious Uveitis after Local Steroid and/or Methotrexate Injections at A Tertiary Referral Center in New Zealand: A Case Series.
Ocular immunology and inflammationERAP2 Increases the Abundance of a Peptide Submotif Highly Selective for the Birdshot Uveitis-Associated HLA-A29.
Frontiers in immunologyReview of the Current Literature and Our Experience on the Value of OCT-angiography in White Dot Syndromes.
Ocular immunology and inflammationThe Impact of the 'Mis-Peptidome' on HLA Class I-Mediated Diseases: Contribution of ERAP1 and ERAP2 and Effects on the Immune Response.
International journal of molecular sciencesEvaluation of fluocinolone acetonide 0.19 mg intravitreal implant in the management of birdshot retinochoroiditis.
The British journal of ophthalmologyRelationship between changes in retinal nerve fiber layer thickness measured by SD-OCT and changes in visual field parameters in birdshot chorioretinopathy.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle OphthalmologieHLA-A alleles including HLA-A29 affect the composition of the gut microbiome: a potential clue to the pathogenesis of birdshot retinochoroidopathy.
Scientific reportsCharacteristics, Upon Presentation, of a Cohort of Hispanic Patients with Birdshot Retinochoroidopathy.
Puerto Rico health sciences journalThe impact of impending / onset of vision loss on depression, anxiety, and vision-related quality of life in Birdshot-Retinochoroiditis and Serpiginous Choroiditis.
PloS oneCreating a Health Utility Value for Birdshot Chorioretinopathy.
Ocular immunology and inflammationFixed-Luminance and Multi-Luminance Flicker Electroretinography Parameters in Patients with Early Active Birdshot Chorioretinopathy.
Ocular immunology and inflammationBirdshot chorioretinopathy presenting in a teenager.
American journal of ophthalmology case reportsOscillatory potentials in patients with birdshot chorioretinopathy.
Documenta ophthalmologica. Advances in ophthalmologyPeripheral Capillary Non-perfusion in Birdshot Retinochoroiditis: A Novel Finding on Ultra-widefield Fluorescein Angiography.
Ocular immunology and inflammationINDOLENT, NONPROGRESSIVE, MULTIFOCAL CHOROIDAL LESIONS: A Presumed Benign Choroidal Lymphoid Disease.
Retina (Philadelphia, Pa.)Activation of the interleukin-23/interleukin-17 signalling pathway in autoinflammatory and autoimmune uveitis.
Progress in retinal and eye researchNot All That Flickers Is Snow.
Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology SocietyThe roles of ERAP1 and ERAP2 in autoimmunity and cancer immunity: New insights and perspective.
Molecular immunologyReproducibility of Full-field Electroretinogram Measurements in Birdshot Chorioretinopathy Patients: An Intra- and Inter-visit Analysis.
Ocular immunology and inflammationIMMUNE-MEDIATED INTRAOCULAR INFLAMMATION. A REVIEW.
Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnostiTopographic correlation between multifocal electroretinography, microperimetry, and spectral-domain optical coherence tomography of the macula in patients with birdshot chorioretinopathy.
Journal of ophthalmic inflammation and infectionHigh Resolution DNA Typing of Human Leukocyte Antigen A29 in Familial Birdshot Chorioretinopathy.
Ocular immunology and inflammationChoroidal Structural Changes in Patients with Birdshot Chorioretinopathy.
Ocular immunology and inflammationCHOROIDAL LESIONS UNRESPONSIVE TO FLUOCINOLONE ACETONIDE INTRAVITREAL IMPLANT IN BIRDSHOT CHORIORETINOPATHY.
Retinal cases & brief reportsEpidemiology of Adult Uveitis in a Northern Ireland Tertiary Referral Centre.
The Ulster medical journalLong-term outcomes of systemic corticosteroid-sparing immunomodulatory therapy for Birdshot Retinochoroidopathy.
Ocular immunology and inflammationVisual acuity loss and development of ocular complications in white dot syndromes: a longitudinal analysis of 3 centers.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle OphthalmologieAssociation of Fundus Autofluorescence Findings and Outer Retinal Lesions on Optical Coherence Tomography With Visual Acuity in Birdshot Chorioretinopathy.
Journal of vitreoretinal diseasesImplications of Birdshot-Like Uveitis on the Pathogenesis of Birdshot Chorioretinopathy-Reply.
JAMA ophthalmologyImplications of Birdshot-Like Uveitis on the Pathogenesis of Birdshot Chorioretinopathy.
JAMA ophthalmologyEVALUATION OF PHOTORECEPTORS, RETINAL CAPILLARY PLEXUSES, AND CHORIOCAPILLARIS IN PATIENTS WITH BIRDSHOT CHORIORETINOPATHY.
Retina (Philadelphia, Pa.)Unilateral Birdshot Chorioretinopathy in an Elderly Patient.
Rhode Island medical journal (2013)Endophthalmitis following cataract surgery and intracameral antibiotic: Moxifloxacin resistant Staphylococcus epidermidis.
American journal of ophthalmology case reportsComparison of choroidal neovascularization secondary to white dot syndromes and age-related macular degeneration by using optical coherence tomography angiography.
Clinical ophthalmology (Auckland, N.Z.)Five-Year Trends in Multifocal Electroretinogram for Patients With Birdshot Chorioretinopathy.
American journal of ophthalmologyDexamethasone implantation in birdshot chorioretinopathy - long-term outcome.
International medical case reports journalLow-grade "benign" birdshot retinochoroiditis: prevalence and characteristics.
International ophthalmologyHow ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I Proteins.
Frontiers in immunologyThe genetics, structure and function of the M1 aminopeptidase oxytocinase subfamily and their therapeutic potential in immune-mediated disease.
Human immunologyOutcomes of "Early" Withdrawal of Corticosteroid Sparing Immunomodulatory Therapy for Birdshot Retinochoroidopathy.
Ocular immunology and inflammationUse of En Face Swept-Source Optical Coherence Tomography Angiography in Identifying Choroidal Flow Voids in 3 Patients With Birdshot Chorioretinopathy.
JAMA ophthalmologyADALIMUMAB THERAPY FOR REFRACTORY BIRDSHOT CHORIORETINOPATHY.
Retina (Philadelphia, Pa.)Birdshot-like Chorioretinopathy Associated With Pembrolizumab Treatment.
JAMA ophthalmologyNon-Occlusive Retinal Vascular Inflammation and Role of Red Blood Cell Deformability in Birdshot Chorioretinopathy.
Ocular immunology and inflammationChoroidal Thickness in Birdshot Retinochoroiditis Over a 2-Year Period.
Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur AugenheilkundeAllele-specific Alterations in the Peptidome Underlie the Joint Association of HLA-A*29:02 and Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) with Birdshot Chorioretinopathy.
Molecular & cellular proteomics : MCPNeed for Quantitative Measurement Methods for Posterior Uveitis: Comparison of Dual FA/ICGA Angiography, EDI-OCT Choroidal Thickness and SUN Vitreous Haze Evaluation in Stromal Choroiditis.
Klinische Monatsblatter fur AugenheilkundePERIVASCULAR THICKENING ON OPTICAL COHERENCE TOMOGRAPHY AS A MARKER OF INFLAMMATION IN BIRDSHOT RETINOCHOROIDITIS.
Retina (Philadelphia, Pa.)Tocilizumab for the treatment of birdshot uveitis that failed interferon alpha and anti-tumor necrosis factor-alpha therapy: two cases report and literature review.
Clinical rheumatologyThe diagnostic usefulness of the negative electroretinogram.
Archivos de la Sociedad Espanola de OftalmologiaBirdshot Chorioretinopathy.
Ocular immunology and inflammationMultimodal Imaging in Birdshot Retinochoroiditis.
Ocular immunology and inflammationSafety profile and efficacy of tacrolimus in the treatment of birdshot retinochoroiditis: a retrospective case series review.
The British journal of ophthalmologyAntigen-specificity of antiretinal antibodies in patients with noninfectious uveitis.
Canadian journal of ophthalmology. Journal canadien d'ophtalmologieNon-invasive method of monitoring retinal vasculitis in patients with birdshot chorioretinopathy using optical coherence tomography.
The British journal of ophthalmologyINCREASED PHOTORECEPTOR OUTER SEGMENT VOLUME FOLLOWING SYSTEMIC TREATMENT OF BIRDSHOT CHORIORETINOPATHY.
Retinal cases & brief reportsDistinguishing White Dot Syndromes With Patterns of Choroidal Hypoperfusion on Optical Coherence Tomography Angiography.
Ophthalmic surgery, lasers & imaging retinaFundus Autofluorescence Findings in Eyes With Birdshot Chorioretinitis.
Investigative ophthalmology & visual scienceThe Value of Diagnostic Work-Up in the Evaluation of White Dot Syndromes.
Ophthalmic surgery, lasers & imaging retinaAdalimumab in refractory cystoid macular edema associated with birdshot chorioretinopathy.
International ophthalmologyIL-6 blockade in the management of non-infectious uveitis.
Clinical rheumatologyTWENTY-FOUR MONTH FOLLOW-UP OF TOCILIZUMAB THERAPY FOR REFRACTORY UVEITIS-RELATED MACULAR EDEMA.
Retina (Philadelphia, Pa.)Feasibility of swept-source OCT for active birdshot chorioretinopathy.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle OphthalmologieChoroidal Imaging with Swept-Source Optical Coherence Tomography in Patients with Birdshot Chorioretinopathy: Choroidal Reflectivity and Thickness.
OphthalmologyAnalysis of autofluorescence pattern in birdshot chorioretinopathy.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle OphthalmologieVisualization of Photoreceptors in Birdshot Chorioretinopathy Using Adaptive Optics Scanning Laser Ophthalmoscopy: A Pilot Study.
Ocular immunology and inflammationMulti-modal imaging and anatomic classification of the white dot syndromes.
International journal of retina and vitreousWhy birdshot retinochoroiditis should rather be called 'HLA-A29 uveitis'?
The British journal of ophthalmologyContribution of dual fluorescein and indocyanine green angiography to the appraisal of posterior involvement in birdshot retinochoroiditis and Vogt-Koyanagi-Harada disease.
International ophthalmologyElectroretinogram and visual field changes in a case of birdshot chorioretinopathy.
Documenta ophthalmologica. Advances in ophthalmologyRETINAL CAPILLARY DENSITY IN PATIENTS WITH BIRDSHOT CHORIORETINOPATHY.
Retina (Philadelphia, Pa.)Visual response and anatomical changes on sequential spectral-domain optical coherence tomography in birdshot chorioretinopathy treated with local corticosteroid therapy.
International journal of retina and vitreousDELINEATION OF CHOROIDAL AND RETINAL LESIONS IN POSTERIOR UVEITIS BY MULTISPECTRAL WIDE-FIELD SCANNING LASER OPHTHALMOSCOPY.
Retina (Philadelphia, Pa.)POOR PROGNOSTIC FACTORS IN PATIENTS WITH BIRDSHOT RETINOCHOROIDOPATHY.
Retina (Philadelphia, Pa.)Efficacy of Anti-IL6-Receptor Tocilizumab in Refractory Cystoid Macular Edema of Birdshot Retinochoroidopathy Report of Two Cases and Literature Review.
Ocular immunology and inflammationOPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF A29 BIRDSHOT CHORIORETINOPATHY COMPLICATED BY RETINAL NEOVASCULARIZATION.
Retinal cases & brief reportsNew insights into the genetic component of non-infectious uveitis through an Immunochip strategy.
Journal of medical geneticsChoroidal Findings in Eyes With Birdshot Chorioretinitis Using Enhanced-Depth Optical Coherence Tomography.
Investigative ophthalmology & visual scienceBirdshot Retinochoroidopathy: Prognostic Factors of Long-term Visual Outcome.
American journal of ophthalmologyMolecular and pathogenic effects of endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 in MHC-I-associated inflammatory disorders: Towards a unifying view.
Molecular immunologyAssessment of retinal vascular calibres as a biomarker of disease activity in birdshot chorioretinopathy.
Acta ophthalmologicaCLINICOPATHOLOGICAL CORRELATION IN A PATIENT WITH PREVIOUSLY TREATED BIRDSHOT CHORIORETINOPATHY.
Retinal cases & brief reportsEfficacy of Methylprednisolone Pulse Followed by Oral Prednisone in Birdshot Chorioretinopathy.
Ocular immunology and inflammationSpatial agreement between Goldmann visual field defects and fundus autofluorescence in patients with birdshot chorioretinopathy.
Journal of ophthalmic inflammation and infectionMultimodal imaging of the disease progression of birdshot chorioretinopathy.
Acta ophthalmologicaChoroidal Neovascularization Associated With Birdshot Chorioretinopathy.
Ophthalmic surgery, lasers & imaging retinaBirdshot chorioretinopathy: current knowledge and new concepts in pathophysiology, diagnosis, monitoring and treatment.
Orphanet journal of rare diseasesWALDENSTRÖM'S MACROGLOBULINEMIA MASQUERADING AS BIRDSHOT CHORIORETINOPATHY.
Retinal cases & brief reportsBirdshot Retinochoroidopathy: Differences in Clinical Characteristics between Patients with Early and Late Age of Onset.
Ocular immunology and inflammationIn Response to: "Baddar D, Goldstein DA. HLA-A29-positive Birdshot Chorioretinopathy in a Hispanic Patient".
Ocular immunology and inflammationTh17 and regulatory T cells are increased in blood of patients with birdshot chorioretinopathy.
Acta ophthalmologicaINTRAVITREAL DEXAMETHASONE IMPLANTATION FOR BIRDSHOT CHORIORETINOPATHY.
Retinal cases & brief reportsBIRDSHOT CHORIORETINITIS LESIONS ON INDOCYANINE GREEN ANGIOGRAPHY AS AN INDICATOR OF DISEASE ACTIVITY.
Retina (Philadelphia, Pa.)ANALYSIS OF THREE-DIMENSIONAL CHOROIDAL VOLUME WITH ENHANCED DEPTH IMAGING FINDINGS IN PATIENTS WITH BIRDSHOT RETINOCHOROIDOPATHY.
Retina (Philadelphia, Pa.)Strong topical steroid, NSAID, and carbonic anhydrase inhibitor cocktail for treatment of cystoid macular edema.
International medical case reports journalElevated Serum Immune Mediators and Subclinical Inflammation in HLA-A29-associated Birdshot Chorioretinopathy.
Ocular immunology and inflammationShort-Wavelength Automated Perimetry Parameters at Baseline and Following Remission in Patients With Birdshot Retinochoroidopathy.
American journal of ophthalmologyQuantitative Assessment of Retinal Degeneration in Birdshot Chorioretinopathy Using Optical Coherence Tomography.
Ophthalmic surgery, lasers & imaging retinaHLA-A29-POSITIVE BIRDSHOT CHORIORETINOPATHY IN AN AFRICAN AMERICAN PATIENT.
Retinal cases & brief reportsOzurdex for the Treatment of a Patient with Birdshot Chorioretinopathy.
Case reports in ophthalmologyPARACENTRAL ACUTE MIDDLE MACULOPATHY IN BIRDSHOT CHORIORETINOPATHY: A NOVEL ASSOCIATION.
Retinal cases & brief reportsRETINAL AND CHOROIDAL VASCULATURE IN BIRDSHOT CHORIORETINOPATHY ANALYZED USING SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.
Retina (Philadelphia, Pa.)Molecular Genetic Advances in Uveitis.
Progress in molecular biology and translational scienceResults of intravitreal dexamethasone implant 0.7 mg (Ozurdex®) in non-infectious posterior uveitis.
International journal of ophthalmologyVisual Electrodiagnostic Testing in Birdshot Chorioretinopathy.
Journal of ophthalmologyVisual Acuity in Birdshot Retinochoroidopathy Evaluation.
American journal of ophthalmologyCHARACTERISTICS AND LONG-TERM OUTCOME OF PATIENTS WITH NONINFECTIOUS RETINAL VASCULITIS.
Retina (Philadelphia, Pa.)Diagnostic Sensitivity of Indocyanine Green Angiography for Birdshot Chorioretinopathy.
JAMA ophthalmologyAssociações
Organizações que acompanham esta doença — pra ter apoio e orientação
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Comunidades
Grupos ativos de quem convive com esta doença aqui no Raras
Ainda não existe comunidade no Raras para Corio-retinopatia "birdshot"
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- The Impact of ERAP1 and ERAP2 Haplotype Combinations on Susceptibility and Severity of Birdshot Chorioretinitis.
- NON-INFECTIOUS POSTERIOR UVEITIDES - Atypicals, Variants, and Masquerades: the jungle of differential diagnosis.
- Birdshot Chorioretinopathy with Cystoid Macular Oedema.
- Viral triggers and genetic predisposition in ocular autoimmunity: unraveling the breakdown of immune privilege and advancing targeted therapeutics.
- Sex-Related Effects on the Clinical Presentation of Uveitis.
- Oral cyclophosphamide as part of the treatment regimen in patients with nonparaneoplastic autoimmune retinopathy secondary to birdshot chorioretinopathy.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:179(Orphanet)
- OMIM OMIM:605808(OMIM)
- MONDO:0011599(MONDO)
- GARD:5926(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Q4916140(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
