É um tipo de câncer cerebral agressivo e que se espalha, originado no cerebelo (a parte do cérebro que controla o equilíbrio e a coordenação). Ele é chamado de "embrionário" porque se desenvolve a partir de células muito jovens. Atinge principalmente crianças e tem a tendência de se espalhar para outras partes do cérebro e da medula espinhal através do líquido que circula por ali (o líquido cefalorraquidiano). Os sinais e sintomas incluem dificuldade para manter o equilíbrio do tronco, problemas ao andar, cansaço extremo (letargia), dor de cabeça e vômitos. Existem quatro tipos principais deste tumor, identificados pela análise das células ao microscópio: meduloblastoma clássico, meduloblastoma de grandes células/anaplásico, meduloblastoma desmoplásico/nodular e meduloblastoma com nodularidade extensa.
Introdução
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É um tipo de câncer cerebral agressivo e que se espalha, originado no cerebelo (a parte do cérebro que controla o equilíbrio e a coordenação). Ele é chamado de "embrionário" porque se desenvolve a partir de células muito jovens. Atinge principalmente crianças e tem a tendência de se espalhar para outras partes do cérebro e da medula espinhal através do líquido que circula por ali (o líquido cefalorraquidiano). Os sinais e sintomas incluem dificuldade para manter o equilíbrio do tronco, problemas ao andar, cansaço extremo (letargia), dor de cabeça e vômitos. Existem quatro tipos principais deste tumor, identificados pela análise das células ao microscópio: meduloblastoma clássico, meduloblastoma de grandes células/anaplásico, meduloblastoma desmoplásico/nodular e meduloblastoma com nodularidade extensa.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 17 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 38 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
6 genes identificados com associação a esta condição. Padrão de herança: Not applicable.
Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:189574
CytoplasmNucleusCytoplasm, cytoskeletonCell junction, adherens junctionCell junctionCell membraneCytoplasm, cytoskeleton, microtubule organizing center, centrosomeCytoplasm, cytoskeleton, spindle poleSynapseCytoplasm, cytoskeleton, cilium basal body
Colorectal cancer
A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history.
Plays a role in the control of cellular growth (PubMed:18285427). May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH)
Membrane
Medulloblastoma
Malignant, invasive embryonal tumor of the cerebellum with a preferential manifestation in children.
Negative regulator in the hedgehog/smoothened signaling pathway (PubMed:10559945, PubMed:10564661, PubMed:10806483, PubMed:12068298, PubMed:12975309, PubMed:15367681, PubMed:22365972, PubMed:24217340, PubMed:24311597, PubMed:27234298, PubMed:28965847). Down-regulates GLI1-mediated transactivation of target genes (PubMed:15367681, PubMed:24217340, PubMed:24311597). Down-regulates GLI2-mediated transactivation of target genes (PubMed:24217340, PubMed:24311597). Part of a corepressor complex that a
CytoplasmNucleus
Medulloblastoma
Malignant, invasive embryonal tumor of the cerebellum with a preferential manifestation in children.
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29332244). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on
CytoplasmNucleus
Neuropathy, hereditary sensory and autonomic, 3
A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN3 patients manifest a variety of symptoms such as alacrima, decreased taste, decreased sensitivity to pain and temperature, vasomotor instability, hypoactive or absent deep tendon reflexes, vomiting crises, and gastrointestinal dysfunction.
Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May
NucleusCytoplasm, cytoskeleton, microtubule organizing center, centrosome
Breast cancer
A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case.
Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, prevent
Cell projection, cilium membraneCell membrane
Medulloblastoma
Malignant, invasive embryonal tumor of the cerebellum with a preferential manifestation in children.
Medicamentos aprovados (FDA)
1 medicamento encontrado nos registros da FDA americana.
Variantes genéticas (ClinVar)
19,161 variantes patogênicas registradas no ClinVar.
Classificação de variantes (ClinVar)
Distribuição de 2,497 variantes classificadas pelo ClinVar.
Vias biológicas (Reactome)
51 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Meduloblastoma
Selecione um estado ou use sua localização para ver resultados.
Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
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Outros ensaios clínicos
337 ensaios clínicos encontrados, 36 ativos.
Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 4.329
Extraneural metastases of pediatric brain tumors: a systematic review.
Brain tumors are the most common solid neoplasm in children, accounting for 25% of pediatric cancer cases, with an incidence rate of 6.23 per 100,000. In addition, up to 2% of these patients will develop extraneural metastases associated with a significantly poorer prognosis. The aim of this study was to investigate the incidence, presentation patterns, and neurosurgical considerations associated with extraneural metastases of primary pediatric brain tumors. Using PRISMA guidelines, a search was conducted in the PubMed database to identify all full-text articles published in the English language up to May 2024 that described extraneural metastases in the pediatric population. The included studies comprised retrospective case reports and case series detailing the occurrence of extraneural metastasis following diagnosis of a primary brain tumor. Statistical differences between groups were assessed using the Mann-Whitney U-test for continuous variables and the chi-square test for categorical variables. Of 3811 articles reviewed, 124 articles that included 399 patients (male-to-female ratio of 1.46) with extraneural metastases were identified and analyzed. The mean age at diagnosis of the primary tumor was 8.78 (SD 4.92) years. Latency (the time from diagnosis of the primary tumor to appearance of extraneural metastases) increased with age, with a mean of 19.31 (SD 22.75) months. Medulloblastomas were the most frequent tumors leading to extraneural metastases. Surgical interventions, particularly tumor resection and shunt placement, played a crucial role in the management of the disease, with 79% of children undergoing surgery. Among these patients, placement of a ventriculoperitoneal shunt was associated with a significantly higher occurrence of abdominal metastases (p < 0.00001), whereas lymph node and lung metastases were more frequent in patients without shunts. As nearly all pediatric brain tumors carry a risk of extraneural metastases, these findings provide insights into the metastatic behavior of various tumors and highlight that surgery can influence the pattern of metastastic dissemination. This confirms the need for personalized follow-up and clinical management strategies based on tumor type, age, and surgical approach.
A photoreceptor state links aggressive brain tumors in children.
In this issue of Cancer Cell, Gudenas et al. reveal that Group 3 medulloblastoma, pineoblastoma, and retinoblastoma converge on a shared tumor-associated photoreceptor signature rooted in transient developmental progenitors. This work reframes these malignancies as diseases of common developmental vulnerability and identifies shared transcriptional dependencies with potential therapeutic relevance.
Orthogonal disentanglement of single-cell multi-omics reveals private and shared drivers of tissue development and pathogenesis.
Characterizing gene expression and regulatory dynamics underlying both normal tissue function and disease progression requires an integrative analysis of single-cell multi-omics data. However, the asynchrony of gene regulation and the snapshot of single-cell multi-omics data give rise to private signals unique to each omics layer and shared signals reflecting cross-modality coordination. Here, we present Omics Separation Modeling using Domain Adaptation (OmiDos), a flexible annotation-free deep learning framework that disentangles omic-specific and interomic shared latent variables in multi-omics data with private-shared component analysis. Its modular architecture enables seamless extension to incorporate adversarial learning for unpaired data misalignment and to restructure its components to leverage the maximum mean discrepancy regularization, thereby minimizing interference with biological variability. Through this disentanglement, OmiDos enables the estimation of gene expression and regulatory dynamics at finer biological granularity and empowers various downstream analyses. We demonstrated the superior performance of OmiDos in terms of clustering accuracy, batch-effect correction, and misalignment resolution across datasets spanning diverse platforms and tissue types. In mouse secondary palate development, OmiDos precisely identified a cell type-specific unlinked distal enhancer, elucidating its essential role in the regulation of epithelial cell differentiation and migration. The application of OmiDos to medulloblastoma revealed a potential role deficiency in driving partial closure of the distal enhancer region of Neurod1 may contribute to the progression of medulloblastoma from normal to tumor states.
A transcription regulator atlas identifies TOX3 as an Atoh1 coactivator in cerebellar development and tumorigenesis.
Organ development and function are orchestrated by intricate transcriptional circuits. Here, we present a comprehensive atlas profiling 1,904 transcription regulators in the brain, cerebellum, heart, kidney, liver, ovary, and testis of fetal, neonatal, and adult mice. Using this dataset, we uncover Thymocyte Selection-Associated High Mobility Group Box Family Member 3 (TOX3) as a potential coactivator of Atoh1 in cerebellar granule neuron progenitors (GNPs). Tox3-deficient mice display severe ataxia and cerebellar hypoplasia, driven by depletion of GNPs, diminished Atoh1 expression, and impaired primary cilia. Single-nucleus RNA-sequencing analyses reveals compromised maintenance of the progenitor pool. TOX3 is also highly expressed in subsets of medulloblastoma, and its deletion reduces cerebellar neoplasia and prolongs survival in a mouse model. Mechanistically, how lineage-defining factors such as Atoh1 drive robust gene expression despite weak intrinsic transactivation activity remains unclear. We show that Tox3 physically associates with Atoh1 and co-occupies shared regulatory elements, converting an otherwise weak single-copy Atoh1-responsive E-box into a highly active enhancer that drives transcriptional activation by up to 120-fold, including at an ultraconserved E-box downstream of Atoh1 itself. Cross-species single-cell comparisons further show an association between Tox3 expression and cerebellum expansion during vertebrate evolution. Together, this work supports Tox3 as a critical Atoh1 coactivator in cerebellar development, tumorigenesis, and evolution, while providing an atlas and screening strategy as a valuable resource for exploring novel transcriptional regulators in organogenesis and tissue physiology.
Longitudinal Detection of Tumor-Specific Peptides in Cerebrospinal Fluid for Pediatric Brain Tumor Surveillance.
Pediatric brain tumor survivors remain at high risk of recurrence, yet current surveillance strategies relying on neuroimaging and cerebrospinal fluid (CSF) cytology have limited sensitivity for early or minimal disease. Tumor-specific peptides (TSPs) derived from individual tumors represent a promising class of highly specific biomarkers for longitudinal disease monitoring through CSF-based proteomic analysis. In this study, tumor tissue and serial CSF samples from six pediatric brain tumor patients (five medulloblastomas and one atypical teratoid/rhabdoid tumor (ATRT)) were analyzed using an integrated proteogenomic workflow combining discovery and targeted mass spectrometry. TSPs were identified from resected tumor tissue and matched against shotgun CSF proteomic datasets to nominate candidate biomarkers. High-confidence peptides were synthesized as isotopically labeled standards and quantified longitudinally using targeted multiple reaction monitoring. Two TSP biomarkers derived from individualized pediatric brain tumors (one medulloblastoma and one ATRT) demonstrated robust detection in serial CSF samples and exhibited temporal concordance with radiographic disease course, declining with treatment response and increasing during disease progression. These findings establish the feasibility of detecting and longitudinally quantifying TSPs in CSF and support further investigation of individualized proteomic biomarkers for treatment response monitoring and disease surveillance in pediatric brain tumors.
Publicações recentes
Nanoparticle-delivered resiquimod induces brain tumor regression in medulloblastoma and diffuse midline glioma models by interrupting paracrine growth support and activating myeloid immune signaling and phagocytosis.
Patient-derived pediatric brain tumor orthotopic xenografts and tumor organoids faithfully recapitulate primary tumors.
Harnessing Phytochemicals for Brain Cancer Therapy: Insights Into Medulloblastoma and Glioblastoma Treatment.
Radiation-Induced Sphenoid Wing Meningioma After Childhood Medulloblastoma: A Case Report.
AMBRA1 enhances Sonic Hedgehog signaling during cerebellar development and in medulloblastoma.
📚 EuropePMC6.714 artigos no totalmostrando 193
PRDM players in Central Nervous System Cancers: state of the art and future perspectives.
Critical reviews in oncology/hematologyExtraneural metastases of pediatric brain tumors: a systematic review.
Journal of neurosurgery. PediatricsTreatment strategies for relapsed medulloblastoma in the pediatric population: illustrative case.
Journal of neurosurgery. Case lessonsSomatic mutation in human cerebellum illustrates neuron type-specific patterns of age-related mutation.
bioRxiv : the preprint server for biologyA photoreceptor state links aggressive brain tumors in children.
Cancer cellTargeting tumor-associated macrophages-induced IGF1/PI3K/Zic1 axis triggers SHH medulloblastoma regression and chemosensitization.
Neuro-oncologyRAC1 Regulates SHH-Medulloblastoma Growth via GLI-Mediated Transcription.
Neuro-oncologyLncRNA-HLX-2-7/HLX axis-dependent metabolic reprogramming drives cancer progression in group 3 medulloblastoma.
Acta neuropathologica communicationsDurable disease control in a radiation-induced high-grade glioma harboring NF1 and PTPN11 co-mutations.
Neuro-oncology advancesOrthogonal disentanglement of single-cell multi-omics reveals private and shared drivers of tissue development and pathogenesis.
Proceedings of the National Academy of Sciences of the United States of AmericaA transcription regulator atlas identifies TOX3 as an Atoh1 coactivator in cerebellar development and tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of AmericaAtypical Teratoid/Rhabdoid Tumor of the Posterior Fossa Mimicking Medulloblastoma in an Infant: A Case Report.
CureusDiagnosis, treatment, and postoperative follow-up of intracranial Ewing sarcoma (EWS): a case report.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryCognitive outcomes after radiotherapy for medulloblastoma: a voxel-based analysis.
International journal of radiation oncology, biology, physicsIntegrated Diagnostic and Surgical Management of Pediatric CNS Tumors: A Single-Centre Prognostic Analysis.
Diagnostics (Basel, Switzerland)Longitudinal Detection of Tumor-Specific Peptides in Cerebrospinal Fluid for Pediatric Brain Tumor Surveillance.
CellsExploiting Metabolic Dependencies for Therapeutic Targeting of Brain Cancers.
Cancer lettersGroup 4 Medulloblastomas of Early Childhood Treated With High-Dose Chemotherapy- and Craniospinal Irradiation-Sparing Approach.
Pediatric blood & cancerONC206 demonstrates potent anti-tumorigenic activity and is a potential novel therapeutic strategy for high-risk medulloblastoma.
Neuro-oncologyBrain tumor detection based on transcription regulation features identified from public cerebrospinal fluid cell-free DNA sequencing data.
Translational cancer researchExploring the lactate-metabolism related characteristics during the development of medulloblastoma through single-cell and bulk RNA-seq.
Translational cancer researchImmunotherapy approaches for the treatment of relapsed or progressive medulloblastoma.
Journal of neuro-oncologyCell-free DNA methylation-based detection of organ damage following proton versus photon radiotherapy: a case series.
Translational pediatricsMolecular and clinical features of a Japanese medulloblastoma cohort: Subgroup-specific prognostic stratification using economical/accessible diagnostic methods.
Brain pathology (Zurich, Switzerland)An interpretable machine learning model for predicting prognosis of medulloblastoma integrating genetic and clinical features.
Communications medicinePrognostic factors in adult patients with medulloblastoma.
Neuro-oncology practiceCMA-mediated USP9X degradation promotes SHH medulloblastoma progression by facilitating SUFU ubiquitination.
Clinical and translational medicineDifferentiating medulloblastoma and pilocytic astrocytoma in children based on multimodal MRI radiomics model.
NeuroradiologyA tumor-associated photoreceptor signature unifies distinct central nervous system malignancies.
Cancer cellCraniospinal irradiation plus tumor-bed boost with standard adjuvant chemotherapy OR high-dose chemotherapy plus autologous stem cell transplant as a radiation-sparing approach in WNT medulloblastoma of early childhood: Fire OR Ice?
Journal of neuro-oncologyPrimary Pediatric Brain Tumors in a Tertiary Referral Center in Iran: A 13-Year Retrospective Analysis.
Archives of Iranian medicinePublisher Correction: An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate.
Nature communicationsGenome-wide DNA methylation analysis of pediatric medulloblastomas from a Brazilian cohort: an exploratory study.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of MexicoDNMT3A R882C variant in a patient with a presumed pineal gland tumor, highlighting potential tumor susceptibility in Tatton-Brown-Rahman syndrome.
Cancer geneticsMedulloblastoma masquerading as tuberculous meningitis in a pediatric patient.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryTrkA activation sustains chemotherapy resistance in chemotolerant medulloblastoma cells.
Acta neuropathologica communicationsModeling pediatric brain tumors with human stem cells.
Frontiers in cellular neuroscienceHigh human cytomegalovirus antigen expression in pediatric medulloblastoma tissue is associated with poor event-free survival.
Neuro-oncology advancesAntigen Specificity and Cell Engineering Determine CAR T Cell Efficacy in Group 3 Medulloblastoma.
Research squareBarriers to Receiving Proton-Craniospinal Irradiation for Pediatric Medulloblastoma Patients at a Rural Tertiary Care Center.
CureusA Systematic Review and Meta-Analysis of Executive Function Outcomes in Pediatric Central Nervous System Tumor Survivors.
Actas espanolas de psiquiatriaUse of Small-Molecule Inhibitors of CILK1 and AURKA as Cilia-Promoting Drugs to Decelerate Medulloblastoma Cell Replication.
BiomedicinesWnt Signaling in Tumorigenesis: From Molecular Mechanisms to Precision Therapeutic Targets.
Current topics in medicinal chemistryClinical and translational progress in oncolytic virotherapy for pediatric CNS tumors.
Journal of neuro-oncologyPhosphoenolpyruvate carboxykinase 2 as a prognostic biomarker: expression and clinical significance in Group 3 and Group 4 medulloblastoma.
Journal of neuro-oncologyDual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model.
Molecular oncologyDistinct cMET inhibitors uncover pharmacological heterogeneity in SHH medulloblastoma cell lines.
Discover oncologyDevelopment of an integrated risk stratification model for metastatic medulloblastoma (M2/3) using clinical, radiologic, and molecular variables.
Neuro-oncology advancesPrimary leptomeningeal medulloblastoma presenting with occipitalgia.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of AustralasiaLong-Term Outcomes Associated With Posterior Fossa Syndrome in Survivors of Childhood Medulloblastoma.
JAMA network openRadiological Spectrum of Leptomeningeal Medulloblastoma: A Case-Based Literature Review With an Additional Case Report.
CureusSpatiotemporal Role of GLI2 in Driving SHH-Medulloblastoma Tumorigenesis.
Neuro-oncologyBuilding a new arsenal: repurposed drugs and metronomic chemotherapy against medulloblastoma.
Expert review of neurotherapeuticsNeurosurgical practice and its influence on postoperative paediatric cerebellar mutism syndrome-the Alder Hey experience.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryBiostatistical benchmarking of neuro-oncology trials.
Neuro-oncology advances"Endocrine Disorders After Treatment for Pediatric Brain Tumors: Long-Term Outcomes and Risk Factors".
The Journal of clinical endocrinology and metabolismUpdate to non-medulloblastoma embryonal tumours: What neuroradiologists should know.
Radiologia7,7"-dimethoxyagastisflavone induced MYCN/MYBL2-dependent apoptosis and metabolism reprogramming in Sonic Hedgehog medulloblastoma.
Journal of translational medicineOrphan G protein-coupled receptor GPR137 regulates ferroptosis by targeting the Wnt/β-catenin pathway in sonic hedgehog-medulloblastoma.
Translational cancer researchResearch progress on the Sonic Hedgehog signaling pathway in the central nervous system: Novel insights.
Neural regeneration researchDetection of structural DNA variants in medulloblastomas using optical genome mapping.
Acta neuropathologica communicationsMemantine to preserve memory and neurocognition following craniospinal irradiation (MEMENTO): a phase 3 randomized controlled trial.
BMC cancer[Deep Learning-Based Automated Segmentation Algorithms of Brain and Vertebral Substructures for Radiotherapy in Pediatric Medulloblastoma].
Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentationInfluence of subgroup, location, and tumor volume in medulloblastoma surgery and consideration for second look surgery: a single institution experience.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryOvercoming the leptomeningeal seeding of medulloblastoma by targeting HSP70.
Translational oncologyStudy of interferon-stimulated gene 15 expression in the medulloblastoma context.
European cytokine networkStage at Diagnosis and International Survival Variation in Childhood Tumors in the BENCHISTA Study.
JAMA network openMitogen-Activated Protein Kinase-3 (MAPK3) Is the Main Target of Microsecond Pulsed Electric Field in Human Medulloblastoma.
Asian Pacific journal of cancer prevention : APJCPAccurate classification of ependymomas and medulloblastomas using Raman spectroscopy and pilot transcriptomic profiling.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopyMIF-CD74 signaling drives immune modulation in medulloblastoma.
Neuro-oncologyMale-biased Yap1-Cd276/B7-H3 axis for immune evasion in medulloblastoma.
Cancer cell[Pediatric neuro-oncology in French-speaking Africa: Current status and challenges].
Bulletin du cancerMetastatic extra-axial medulloblastoma involving the trigeminal nerve: a rare prognostic entity with a comprehensive literature review.
Frontiers in oncologyChildhood brain tumors instruct cranial hematopoiesis and immunotolerance.
Nature geneticsRole of 5-Aminolevulinic Acids in Brain Tumor Surgeries in Pediatrics: A Systematic Review of Case Reports and Series.
CureusAn Evaluation of MACSima and PhenoCycler-Fusion for Spatial Image Analysis in a Medulloblastoma Xenograft Model.
Microscopy research and techniqueSonic Hedgehog Pathway Modulation in Medulloblastoma: Focus on Vismodegib (GDC-0449).
Developmental neurobiologyMachine learning-based identification of extracellular matrix-related prognostic subtypes in SHH-activated medulloblastoma.
Discover oncologyMitoxantrone alters CD24/Siglec-10 expression in malignant brain tumor models.
Scientific reportsExploring the prognostic molecular mechanisms of medulloblastoma through methylation-transcriptome integration.
SAGE open medicineTropism Profiling of Lentiviral Vector Pseudotypes in Diverse Brain Tumor Models.
PharmaceuticsRab24 protein levels show dynamic changes in mouse tissues and human cancers.
Cell and tissue researchA feasibility study of functional preservation in craniospinal irradiation with photon for pediatric medulloblastoma.
Journal of applied clinical medical physicsPreclinical drug screen identifies WEE1 inhibitor and vinca alkaloid as a combination treatment concept for Li-Fraumeni syndrome medulloblastoma.
iScienceSwitching off CK2-mediated activation of survivin offers new therapeutic opportunities in neuroblastoma.
Experimental & molecular medicineRaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects.
Molecular oncologyClonal Profiles in a Li-Fraumeni Syndrome Patient With SHH Medulloblastoma: Clonal Evolution, Genomics, and Clinical Implications.
Pediatric blood & cancerProfiling T-cell activity and exclusion in pediatric medulloblastoma highlights immunotherapy-responsive subgroups.
Journal of neuro-oncologyHigh-dose chemotherapy and craniospinal irradiation-sparing approach for WNT medulloblastoma of early childhood.
Journal of neuro-oncologyPre-operative and intra-operative risk factors of post-operative cerebellar mutism syndrome in pediatric patients undergoing posterior fossa tumor surgery: a systematic review.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryMultiomic integration reveals tumoral heterogeneity of lipid dependence within lethal group 3 medulloblastoma.
Cancer cellAlphaFold3 predictions of novel GLI-SUFU interfaces identify binding-defective SUFU missense variants from medulloblastoma and Gorlin Syndrome patients.
bioRxiv : the preprint server for biologyPreclinical assessment of checkpoint blockade combined with DNA methyltransferase inhibition in high-risk pediatric brain tumors reveals limited therapeutic synergy.
Neuro-oncology advancesImpact of molecular subtypes on postoperative hydrocephalus following resection of posterior fossa medulloblastoma and ependymoma in children: A systematic review and meta-analysis.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryChildren's outcomes in medulloblastoma proton versus photon craniospinal radiotherapy (CURE): meta-analysis.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and OncologySignificance of LEF1, ROR2, Cyclin D1, and DNA Methylation Profiling in the Molecular Classification and Prognosis Prediction of Pediatric Medulloblastoma.
Balkan medical journalA Systematic Review of Evidence on the Clinical Effectiveness of Surveillance Imaging in Children With Medulloblastoma and Ependymoma.
Pediatric blood & cancerCerebello-Pontine Angle Tumors in Children: An Update on Challenging Neoplasms.
Diagnostics (Basel, Switzerland)Erythrocyte-microglia crosstalk contributing to sex differences in pediatric brain tumorigenesis.
Research squareCellular cannibalism in cytology: a distinctive feature of large cell/anaplastic medulloblastoma in a pediatric case.
Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation OncologyTumor-suppressive activities of SA1/STAG2 and effects of PARP impairment during brain development.
Disease models & mechanismsMethylation profiling in neuropathological tumors diagnosis: a comprehensive review.
Frontiers in oncologyIntraoperative drug delivery to hindbrain tumours via an injectable hydrogel is well tolerated and confers survival benefit against atypical teratoid/rhabdoid xenografts.
Drug delivery and translational researchHsa_circ_PCNT sponges hsa-miR-133b to promote SHH medulloblastoma via TAGLN2.
Cellular and molecular life sciences : CMLSOrgan-specific low-dose assessment in pediatric radiotherapy using nanodot OSL and NTCP modeling: Application to medulloblastoma.
Journal of applied clinical medical physicsSubtype-Specific mRNA Signatures of Human Ribosomal Proteins in Pediatric Cancers.
International journal of molecular sciencesStrategies for the Molecular Classification of Medulloblastoma.
BiomedicinesPhase 1 study of mebendazole therapy for refractory/progressive or recurrent pediatric brain tumors.
Neuro-oncology practiceTuning the thermostat. Beyond hot and cold in the medulloblastoma tumor microenvironment.
EBioMedicineIntratumoral heterogeneity of MYC status and methylation subtyping in group 3 medulloblastoma: A case report.
Journal of neuropathology and experimental neurologyNanoparticulate delivery and targeting of RNA to the brain.
Biochimica et biophysica acta. Reviews on cancerOutcomes and Toxicity of Adult Medulloblastoma Treated with Pediatric Multimodal Protocols: A Single-Institution Experience.
Oncology researchPosterior Fossa Group A Ependymoma in Trisomy 21.
Neuropathology : official journal of the Japanese Society of NeuropathologyHuman stem cell models for group 3 medulloblastoma uncover JARID1B as a regulator of the chromatin landscape.
bioRxiv : the preprint server for biologyIdentification of Raptor and GLI1 as USP37 substrates highlight its context-specific function in medulloblastoma cells.
OncogeneGlobal patterns and trends in brain and central nervous system tumors incidence by histological subtype in 185 Countries in 2022: a population-based study.
International journal of surgery (London, England)Functional and therapeutic effects of Glabrescione B delivery by liposomes on Hedgehog-dependent tumors.
Drug delivery and translational researchTranscriptional regulation of protein synthesis by mediator kinase represents a therapeutic vulnerability in MYC-driven medulloblastoma.
Nature communicationsBenchmarking nazionale della sopravvivenza per stadio alla diagnosi dei tumori infantili in Italia (BENCHISTA-ITA): protocollo di studio.
Epidemiologia e prevenzioneA functionally relevant model for interrogating brain tumor-endothelial cell interactions.
Journal of neuroscience methodsMaternal Autoimmune Disease and the Risk of Childhood Cancer Among the Offspring: A Population-Based Cohort Study in Taiwan.
International journal of rheumatic diseasesAn integrated approach to molecular profiling supports precision diagnosis of pediatric medulloblastoma in Argentina amid the resource-constrained setting.
Scientific reports[Endocrine Complications and Their Management Following Treatment of Pediatric Brain Tumors].
No shinkei geka. Neurological surgery[Current Status and Prospects of Clinical Trials for Medulloblastoma and Atypical Teratoid/Rhabdoid Tumor].
No shinkei geka. Neurological surgery[Current Imaging Approaches for Pediatric Brain Tumors].
No shinkei geka. Neurological surgery[Molecular Classification of Medulloblastoma].
No shinkei geka. Neurological surgeryAlbacarcin V adds EPLIN as a novel and promising target for the treatment of female cancers and pediatric medulloblastoma.
Biochemical pharmacologyDescriptive and molecular analysis of pineal parenchymal tumors with clinical correlation.
BMC cancerClinical and Magnetic Resonance Findings for the Diagnosis of Recurrent Tumors versus Radiation-Induced Secondary Tumors of Malignant Pediatric Brain Tumors of the Posterior Fossa.
World neurosurgeryTransient visual loss following endoscopic third ventriculostomy in a child with a posterior fossa tumour: consideration of intracranial pressure control.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryExposure to Acetaminophen (Paracetamol) during Pregnancy and Childhood Cancer: A Population-Based Cohort Study in Taiwan.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive OncologyTargeting TET3 suppresses group 3 medulloblastoma stemness and progression via impairing hypomethylation of Otx2 super-enhancer.
Cell reports. MedicineHidden-driver inference reveals synergistic brain-penetrant therapies for medulloblastoma.
bioRxiv : the preprint server for biologyPIEZO2 in tumors: from mechanobiological switches to activity-targeted therapies.
Journal of experimental & clinical cancer research : CRNational multicentered retrospective review of salvage therapy for pediatric medulloblastoma: a Canadian experience.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryTrends of hospital-based reporting of intracranial neoplasms in Nigeria from 1960 to 2024: A systematic review and pooled analysis of literatures.
Neuro-oncology advancesGPC6 facilitates progression of SHH-subgroup medulloblastoma by enhancing Hedgehog secretion and signaling responses.
Journal of biomedical researchTargeting ERAP1 to disarm Gli activation in Sonic Hedgehog medulloblastoma.
Molecular therapy : the journal of the American Society of Gene TherapyMedulloblastoma stem cell programs: Molecular roadmaps of disease progression.
Developmental cellPrecise diagnosis of pediatric posterior cranial fossa neoplasms based on 2.5D MRI deep learning.
Frontiers in oncologyIn silico drug sensitivity predicts subgroup-specific therapeutics in medulloblastoma patients.
Scientific reportsExploring Novel Applications: Repositioning Clinically Approved Therapies for Medulloblastoma Treatment.
CancersElucidating Neurodevelopmental Trajectories in Cancer with Topic Modeling: Revealing Persistent External Granule Layer Lineages in Medulloblastoma.
bioRxiv : the preprint server for biologySingle-cell multi-omics identifies metabolism-linked epigenetic reprogramming as a driver of therapy-resistant medulloblastoma.
Nature communicationsMedulloblastoma Presenting With Bilateral Internuclear Ophthalmoplegia of Abduction: A Case Report.
CureusIDH mutations are rare events in SHH medulloblastoma.
Acta neuropathologicaDNA Methylation Profiling Classifies and Reveals Origin of Gynecologic Central Nervous System-Like Tumors.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, IncProfiling tumour-infiltrating immune cells in a large paediatric medulloblastoma cohort: a retrospective analysis.
EBioMedicineA Rare Case of Bone Marrow Infiltration of Disseminated Medulloblastoma in a Young Adult.
International journal of hematology-oncology and stem cell researchEpigenomic landscape of the developing human rhombic lip reveals gene regulatory network and non-coding loci of developmental, evolutionary, and disease relevance.
bioRxiv : the preprint server for biologyHierarchical regulation of cerebellar neurogenesis by Sin3A-mediated gene repression.
bioRxiv : the preprint server for biologyCentral Nervous System Embryonal Tumors.
Neuroimaging clinics of North AmericaNon-WNT/non-SHH medulloblastoma in siblings: case report and literature review.
Discover oncologyAhR-Siglec-15 axis regulates lysosomal Ca2+ release for sonic hedgehog medulloblastoma growth via TRPML1.
Protein & cellAdult Medulloblastoma Presenting With Audiovestibular Symptoms and an Alternating Unterberger Test.
CureusInterferon Restores Antigen Presentation and Sensitizes Medulloblastoma to T Cell Killing.
bioRxiv : the preprint server for biologySurgical management and outcome of medulloblastoma patients at Addis Ababa between 2010 and 2018.
Frontiers in oncologyBayesian reappraisal of ACNS0332 and ACNS0334 strengthens subgroup treatment effects in high-risk pediatric Group 3 medulloblastoma.
Neuro-oncology[Plasma lipidomics-based exploration of potential biomarkers of metastasis in pediatric medulloblastoma].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatricsCMKLR1/PKA signaling reinforces sonic hedgehog pathway to promote medulloblastoma pathogenesis.
OncogenesisChallenges and opportunities for treatment of medulloblastoma.
Advances in cancer researchSingle-Cell Heterogeneity of Epigenetic Factor Regulation Deciphers Alteration of RNA Metabolism During Proliferative SHH-Medulloblastoma.
Cancers18F-FDG versus 18F-FDOPA PET in recurrent medulloblastoma: a case study and literature review.
EJNMMI reportsGenetic markers and canonical pathways associated with medulloblastoma: a systematic review and meta-analysis.
Translational pediatricsLong-Term Disease-Free Survival Without Radiotherapy in a Pediatric Patient With Neurofibromatosis Type 1-Associated Medulloblastoma: A Case Report.
CureusOut-of-field dosimetry in VMAT for medulloblastoma using OSLDs.
Radiation protection dosimetrySingle-cell deconstruction of medulloblastoma microenvironment elucidates subtype-specific immune architectures and prognostic molecular signatures.
Cancer lettersHypercalcemia associated with relapsed medulloblastoma due to bone metastasis: illustrative case.
Journal of neurosurgery. Case lessonsAmbient ionization mass spectrometry in brain cancer diagnosis.
Journal of mass spectrometry and advances in the clinical labMolecular subgrouping of pediatric medulloblastoma by mismatch between molecular and structural MRI.
Quantitative imaging in medicine and surgeryEZHIP boosts neuronal-like synaptic gene programs and depresses polyamine metabolism.
Acta neuropathologica communicationsAn Exploratory Application of a Central Nervous System (CNS) Tumor Methylation Classifier in Ovarian Neuroectodermal Tumors.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, IncExploring the causal relationship between telomere regulation, aging and neurological disorders.
Ageing research reviewsMechanistic insights into pharmacokinetic interactions between simvastatin and vismodegib: Implications for optimization of combination therapy in medulloblastoma.
Biochemical and biophysical research communicationsBeyond cell-cell contact: therapeutic potential of Eph signaling in central nervous system tumors.
Frontiers in molecular neuroscienceGenome-wide methylation and copy number variation analysis of medulloblastoma in a Saudi Arabian pediatric population.
Annals of medicine and surgery (2012)The MYC-dependent lncRNA MB3 inhibits apoptosis in Group 3 Medulloblastoma by regulating the TGF-β pathway via HMGN5.
Cell death & diseaseMedulloblastoma chapter - past perspectives and future directions.
Advances in cancer researchThe Medulloblastoma Meta-Analysis Portal Enables Integrative Exploration of Clinical and Genomic Data from Patients.
Cancer researchThe value of cerebrospinal fluid cytology in the diagnosis of atypical medulloblastoma: a case report and review of the literature.
Frontiers in medicineInflammation accelerates metastasis: Medulloblastoma leptomeningeal dissemination.
Developmental cellThe current status of immune checkpoint inhibitors in pediatric CNS tumors: a systematic review with a representative case of CMMRD-associated glioma.
Journal of neuro-oncologyTherapy-related acute myeloid leukemia following aggressive treatment for pediatric medulloblastoma: a case report of a 13-year-old and review of literature.
Annals of medicine and surgery (2012)A case of basal cell nevus syndrome with a SUFU mutation.
Dermatology online journalMultimodal pathomics and clinical features predict postresection permanent hydrocephalus in pediatric medulloblastoma.
Journal of neuro-oncologyA rare case of atypical teratoid rhabdoid tumor (AT/RT) with homozygous SMARCB1 loss and one concurrent somatic heterozygous SMARCA4 variant.
Acta neuropathologica communicationsAdvancing Medulloblastoma Treatment: Molecular Mechanisms, Drug Repurposing, and Precision Therapies.
Molecular diagnosis & therapyWhole genome sequencing-based analysis of genetic predisposition to adult glioblastoma.
NPJ genomic medicineGlobal lncRNA expression profiles in medulloblastoma reveal crucial lncRNA-oncogene interactions in Sonic hedgehog and Group 4.
Neuro-oncology advancesLate Effects in Survivors of Pediatric Medulloblastoma: A Comprehensive Review.
Pediatric blood & cancerClinical, toxicity and long-term neurocognitive outcomes of first-line intensive chemotherapy in infant medulloblastoma: a single-center cohort study following AIEOP recommendations.
Journal of neuro-oncologyIntegrated transcriptomic landscape of medulloblastoma and ependymoma reveals novel tumor subtype-specific biology.
Neuro-oncologyAn integrated analysis of three medulloblastoma clinical trials refines risk-stratification approaches for reducing toxicity and improving survival.
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Extraneural metastases of pediatric brain tumors: a systematic review.
- A photoreceptor state links aggressive brain tumors in children.
- Orthogonal disentanglement of single-cell multi-omics reveals private and shared drivers of tissue development and pathogenesis.Proceedings of the National Academy of Sciences of the United States of America· 2026· PMID 41849387mais citado
- A transcription regulator atlas identifies TOX3 as an Atoh1 coactivator in cerebellar development and tumorigenesis.Proceedings of the National Academy of Sciences of the United States of America· 2026· PMID 41849381mais citado
- Longitudinal Detection of Tumor-Specific Peptides in Cerebrospinal Fluid for Pediatric Brain Tumor Surveillance.
- Nanoparticle-delivered resiquimod induces brain tumor regression in medulloblastoma and diffuse midline glioma models by interrupting paracrine growth support and activating myeloid immune signaling and phagocytosis.
- Patient-derived pediatric brain tumor orthotopic xenografts and tumor organoids faithfully recapitulate primary tumors.
- Harnessing Phytochemicals for Brain Cancer Therapy: Insights Into Medulloblastoma and Glioblastoma Treatment.
- Radiation-Induced Sphenoid Wing Meningioma After Childhood Medulloblastoma: A Case Report.
- AMBRA1 enhances Sonic Hedgehog signaling during cerebellar development and in medulloblastoma.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:616(Orphanet)
- OMIM OMIM:155255(OMIM)
- MONDO:0007959(MONDO)
- GARD:7005(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
- Q1333608(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
