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Dermatite herpetiforme
ORPHA:1656CID-10 · L13.0CID-11 · EB44DOENÇA RARA

A dermatite herpetiforme (DH) é uma doença bolhosa subepidérmica crônica, autoimune, caracterizada por lesões pruriginosas agrupadas, como pápulas, placas urticariformes, eritema e vesículas herpetiformes, com distribuição predominantemente simétrica nas superfícies extensoras dos cotovelos (90%), joelhos (30%), ombros, nádegas, região sacral e face de crianças e adultos. Geralmente seguem-se erosões, escoriações e hiperpigmentação. A DH também pode aparecer como consequência da intolerância ao glúten.

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Introdução

O que você precisa saber de cara

📋

A dermatite herpetiforme (DH) é uma doença bolhosa subepidérmica crônica, autoimune, caracterizada por lesões pruriginosas agrupadas, como pápulas, placas urticariformes, eritema e vesículas herpetiformes, com distribuição predominantemente simétrica nas superfícies extensoras dos cotovelos (90%), joelhos (30%), ombros, nádegas, região sacral e face de crianças e adultos. Geralmente seguem-se erosões, escoriações e hiperpigmentação. A DH também pode aparecer como consequência da intolerância ao glúten.

Pesquisas ativas
2 ensaios
5 total registrados no ClinicalTrials.gov
Publicações científicas
2.628 artigos
Último publicado: 2026 Apr

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
1-5 / 10 000
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
27.0
Europe
Início
All ages
🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: L13.0
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Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🧬
Pele e cabelo
3 sintomas
🦷
Dentes
2 sintomas
🦴
Ossos e articulações
2 sintomas
🩸
Sangue
1 sintomas
🛡️
Imunológico
1 sintomas
📏
Crescimento
1 sintomas

+ 16 sintomas em outras categorias

Características mais comuns

90%prev.
Anemia microcítica
Muito frequente (99-80%)
90%prev.
Fraturas recorrentes
Muito frequente (99-80%)
90%prev.
Urticária
Muito frequente (99-80%)
90%prev.
Intolerância ao glúten
Muito frequente (99-80%)
90%prev.
Bolhas anormais na pele
Muito frequente (99-80%)
90%prev.
Má absorção
Muito frequente (99-80%)
26sintomas
Muito frequente (11)
Frequente (7)
Ocasional (6)
Muito raro (2)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 26 características clínicas mais associadas, ordenadas por frequência.

Anemia microcíticaMicrocytic anemia
Muito frequente (99-80%)90%
Fraturas recorrentesRecurrent fractures
Muito frequente (99-80%)90%
UrticáriaUrticaria
Muito frequente (99-80%)90%
Intolerância ao glútenGluten intolerance
Muito frequente (99-80%)90%
Bolhas anormais na peleAbnormal blistering of the skin
Muito frequente (99-80%)90%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico2.628PubMed
Últimos 10 anos200publicações
Pico202154 papers
Linha do tempo
2026Hoje · 2026🧪 2008Primeiro ensaio clínico📈 2021Ano de pico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
Aprovado1
2Fase 21
·Pré-clínico3
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 5 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Dermatite herpetiforme

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

🟢 Recrutando agora

2 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

Outros ensaios clínicos

5 ensaios clínicos encontrados, 2 ativos.

Distribuição por fase
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

📖Melhor nível de evidência: Revisão
Timeline de publicações
403 papers (10 anos)
#1

Cohort study of neurological and psychiatric morbidity in dermatitis herpetiformis and celiac disease.

Scandinavian journal of gastroenterology2026 Feb 28

Neurological and psychiatric morbidity has been associated with celiac disease but has been scarcely studied in dermatitis herpetiformis (DH), a cutaneous manifestation of celiac disease. Hence, this cohort study aimed to investigate neurological and psychiatric morbidity in patients with DH and celiac disease. The study comprised 368 DH patients and 1,072 celiac disease patients without DH and their 1,099 and 3,197 refences, matched 1:3 on age, sex, calendar period and place of residence. Their neurological and psychiatric morbidity was studied using the Care Register for Health Care and international classification of diseases codes. Hazard ratios (HR) were calculated using Cox proportional hazard model. In DH the risk for any neurological disease was not statistically significantly increased (HR 1.27; 95% CI 0.94-1.71), but Alzheimer's disease and extrapyramidal diseases were found to be more common in DH when compared with their references. In contrast, in celiac disease excess risks for any neurological disease (HR 1.31; 95% CI 1.09-1.56) and particularly for migraine and headaches were detected. The risk for any psychiatric disease was found to be decreased in DH (HR 0.65; 95% CI 0.47-0.90), as were the risks for anxiety and substance abuse. In celiac disease, increased risks for any psychiatric disease (HR 1.20; 95% CI 1.01-1.42), depression, and anxiety disorders were noted. The neurological and psychiatric morbidity of patients with DH and celiac disease patients without DH seems to differ, but the reasons for this varying disease burden remain yet unidentified.

#2

European S2k guidelines on management of autoimmune blistering diseases in children and adolescents.

Journal of the European Academy of Dermatology and Venereology : JEADV2026 Feb 12

Autoimmune blistering diseases (AIBDs) in children and adolescents present a major challenge in diagnosis and management because of their rarity and the presence of other differential diagnoses with blistering. They are potentially serious, and timely diagnosis and optimal management can help prevent morbidity related to both the diseases and their treatments. The Autoimmune Blistering Diseases Task Force of the European Academy of Dermatology and Venereology (EADV) has initiated evidence-based, expert-informed clinical guidelines for the diagnosis, treatment and monitoring of paediatric AIBDs. A writing group conducted a systematic review of the available literature on AIBDs in children and adolescents, and since there is limited strong evidence in the literature, recommendations were formulated by consensus over three rounds of structured feedback and revision by the Core Group and Expert Group of the task force (32 voting experts; >75% agreement threshold). Although all AIBDs-including intra-epidermal and subepidermal blistering disorders-are reported in children, linear IgA dermatosis (LAD) is the most common (42-83%). The diagnostic approach in the paediatric age group does not differ from that in adults. Treatment recommendations are tailored to paediatric patients, taking into account developmental pharmacokinetics, potential adverse effects and the impact of disease and therapy on quality of life. These guidelines provide the first comprehensive, paediatric-focused framework for the diagnosis and management of AIBDs. Implementing the recommendations should harmonize care, reduce treatment-related toxicity and improve quality of life for affected children while steering future research towards critical knowledge gaps.

#3

From photosensitivity to autoimmunity: the role of AI metabolomics in PCT-celiac disease overlap.

Annals of medicine and surgery (2012)2026 Feb

Porphyria cutanea tarda (PCT), caused by hepatic uroporphyrinogen decarboxylase deficiency, may rarely overlap with undiagnosed celiac disease (CD), complicating diagnosis due to shared hepatic and dermatologic features. Both conditions present with skin manifestations such as photosensitivity, blistering, or dermatitis herpetiformis-like lesions, often leading to misclassification. AI-driven metabolomics provides a novel strategy to identify metabolic biomarkers, predict CD with high accuracy through machine learning, and uncover hidden comorbidities in PCT patients. Despite challenges including limited datasets, bioinformatics demands, and regulatory barriers, integrating metabolomics with AI could enhance diagnostic precision and enable personalized management. Multidisciplinary collaboration is critical to translating these technologies into clinical practice for early detection and improved outcomes in PCT-CD overlap.

#4

A systematic review of therapeutic and paradoxical roles of tumor necrosis factor α inhibitors in autoimmune blistering diseases.

Inflammopharmacology2026 Jan

Autoimmune blistering diseases (AIBDs), including pemphigus diseases, pemphigoid diseases, linear immunoglobulin A (IgA) bullous dermatosis (LABD), epidermolysis bullosa acquisita (EBA), and dermatitis herpetiformis (DH), are a group of diseases clinically characterized by erosions and blisters that involve the skin and mucosa. Tumor necrosis factor-alpha (TNF-α), a key inflammatory cytokine, plays a critical role in their pathogenesis. TNF-α inhibitors are used for their immunomodulatory effects but may also induce paradoxical autoimmune blistering. This systematic review aimed to synthesize current evidence on therapeutic and paradoxical effects of TNF-α inhibitors in these diseases. A systematic search of PubMed, Scopus, and Embase was conducted up to March 7th, 2025, following PRISMA guidelines. Studies eligible for inclusion were original human research articles in English reporting therapeutic or paradoxical effects of TNF-α inhibitors, including infliximab, etanercept, adalimumab, certolizumab pegol, and golimumab, on autoimmune bullous diseases. Risk of bias was evaluated using the NIH and Murad et al. assessment tools. A total of 35 studies with 68 patients were included in the treatment application group and 29 studies with 31 subjects were included in the paradoxical reaction group. Infliximab was most frequently associated with favorable outcomes in pemphigus vulgaris (PV), bullous pemphigoid (BP), and EBA, with multiple reports of sustained remission. Etanercept showed partial to complete responses in some cases of PV and BP; however, it was associated with paradoxical induction of BP in several patients. Adalimumab demonstrated therapeutic efficacy in PV and MMP, yet was the most common agent implicated in paradoxical BP and LABD. Paradoxical effects were most often observed in patients treated for non-dermatologic conditions such as rheumatoid arthritis or Crohn's disease. TNF-α inhibitors, particularly infliximab, show therapeutic promise in refractory AIBDs. However, their potential to paradoxically induce blistering diseases, especially with adalimumab and etanercept, necessitates careful patient selection, close monitoring, and individualized risk-benefit assessment.

#5

Dapsone use in dermatology: indication, efficacy and tolerability experience of a UK tertiary dermatology department.

Clinical and experimental dermatology2026 Jan 27

Dapsone has been a quick and affordable treatment option for a diverse range of dermatological pathologies. Although licensed for the management of leprosy and dermatitis herpetiformis, its uses expand to a range of neutrophil- and eosinophil-driven pathologies. This retrospective study examined the use of dapsone at a large tertiary dermatology department in the UK serving a diverse population. In our report, we assess indications for use and treatment efficacy, and provide 3-year follow-up data on clinical outcomes and adverse events, and their frequency. These data demonstrate the unpredictable efficacy of dapsone, and allow dermatologists to better inform their patients regarding possible treatment success with dapsone, as well as to counsel patients regarding the frequency and range of possible adverse events.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC1.552 artigos no totalmostrando 194

2026

Cohort study of neurological and psychiatric morbidity in dermatitis herpetiformis and celiac disease.

Scandinavian journal of gastroenterology
2026

European S2k guidelines on management of autoimmune blistering diseases in children and adolescents.

Journal of the European Academy of Dermatology and Venereology : JEADV
2026

From photosensitivity to autoimmunity: the role of AI metabolomics in PCT-celiac disease overlap.

Annals of medicine and surgery (2012)
2025

Oral mucosa in dermatitis herpetiformis (Duhring's disease): a clinical and mycologic evaluation.

Oral surgery, oral medicine, oral pathology and oral radiology
2025

Health Risks Associated with a Long-Term Gluten-Free Diet and the Potential Protective Role of Anthocyanins.

International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition
2026

A systematic review of therapeutic and paradoxical roles of tumor necrosis factor α inhibitors in autoimmune blistering diseases.

Inflammopharmacology
2025

Celiac Disease as a Genetic Predisposing Factor for Dermatitis Herpetiformis: A Two-Sample Mendelian Randomization Analysis.

Clinical, cosmetic and investigational dermatology
2025

Characteristics and Long-Term Prognosis of Celiac Disease: Comparisons between Patients Diagnosed either in Childhood or Adulthood.

Digestion
2025

Diagnostic accuracy of serological tests for dermatitis herpetiformis: systematic review and Bayesian meta-analysis.

Systematic reviews
2025

Management of Treatment-Resistant Dermatitis Herpetiformis With Tofacitinib: A Case Report.

Clinical case reports
2026

Dapsone use in dermatology: indication, efficacy and tolerability experience of a UK tertiary dermatology department.

Clinical and experimental dermatology
2026

Dermal IgA Is Rare in Celiac Disease and Relatives and Lacks Dermatitis Herpetiformis-Type Colocalization with Transglutaminase 3.

The Journal of investigative dermatology
2025

Unusual site presentation of dermatitis herpetiformis: line-field confocal optical coherence tomography for effective management.

Dermatology reports
2026

Successful Treatment of Refractory Dermatitis Herpetiformis With Upadacitinib.

International journal of dermatology
2025

Price, quality, and availability of gluten-free products in Australia and New Zealand - a cross-sectional study.

Journal of the Royal Society of New Zealand
2025

A Clinico-Epidemiological Study of Various Autoimmune Vesiculobullous Disorders in a Tertiary Care Center.

Cureus
2025

CLINICAL AND HISTOLOGICAL COMPARISON OF CELIAC DISEASE AND DERMATITIS HERPETIFORMIS IN MALE PATIENTS: A TEN-YEAR RETROSPECTIVE STUDY.

Arquivos de gastroenterologia
2025

Dermatitis herpetiformis, celiac disease and their impact on women and their families.

Italian journal of dermatology and venereology
2025

Pemphigus herpetiformis: a single-center tertiary care experience.

Turkish journal of medical sciences
2025

Alpha-Lipoic Acid Reduces Methemoglobin and Oxidative Imbalance in the Blood and Liver Induced by Dapsone in Mice: Molecular Mechanism of Antioxidant Action.

ACS pharmacology &amp; translational science
2026

Itchy rash linked to the gut: a case of dermatitis herpetiformis.

QJM : monthly journal of the Association of Physicians
2025

Gluten-related skin disorders: clinical presentation, diagnostic and treatments.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
2025

HLA DRB1* Allele Lupus Erythematosus, Rheumatoid Arthritis, and other Autoimmune Disorders with Skin Involvement.

Mediterranean journal of rheumatology
2025

Dermatitis herpetiformis successfully treated with dupilumab.

JAAD case reports
2025

Direct Immunofluorescence (DIF) Microscopy of Skin Biopsies From Children: A Retrospective Cohort Study of 986 DIF Studies.

Pediatric dermatology
2025

Efficacy of probiotics in dermatitis herpetiformis management: an umbrella review.

Frontiers in physiology
2025

Prurigo nodularis phenotype in the bullous dermatoses spectrum.

Clinics in dermatology
2025

From Gut to Gray Matter: A Case Report of Posterior Reversible Encephalopathy Syndrome in a Pediatric Patient With Celiac Disease.

Clinical case reports
2025

Enzyme-activating B-cell receptors boost antigen presentation to pathogenic T cells in gluten-sensitive autoimmunity.

Nature communications
2025

Associations of Clinical Presentation of Coeliac Disease with Comorbidities and Complications: A Retrospective Single-Centre Analysis.

Journal of personalized medicine
2024

Iodoform in Surgical Practice: A Comprehensive Review of Its Historical Evolution, Clinical Applications, and Safety Profiles.

Cureus
2024

Rare Association of Dermatitis Herpetiformis and Chronic Plaque Psoriasis.

Clinical case reports
2025

Risk for hospital-treated infections in dermatitis herpetiformis and coeliac disease.

European journal of internal medicine
2025

Inflammatory Myopathies and Autoimmune Gluten-related Disorders: A Scoping Review of Pathophysiological Interconnections and Hypothesis.

Recent advances in inflammation &amp; allergy drug discovery
2024

Evidence of a Causal Relationship Between Body Mass Index and Immune-Mediated and Inflammatory Skin Diseases and Biomarkers: A Mendelian Randomization Study.

Clinical, cosmetic and investigational dermatology
2024

The Role of Nutrition in the Pathogenesis and Treatment of Autoimmune Bullous Diseases-A Narrative Review.

Nutrients
2024

A Comparative Study of Direct Immunofluorescence Patterns in Linear IgA Bullous Dermatosis Versus Dermatitis Herpetiformis.

The American Journal of dermatopathology
2024

Skin as a Reflection of Gut Health: An Overview of Dermatological Manifestations in Primary Neoplastic and Autoimmune Gastrointestinal Disorders.

Cureus
2024

Dermatitis Herpetiformis Duhring.

JMA journal
2024

Laboratory and clinical haemostatic aberrations in primary dermatologic disease: A review.

Thrombosis journal
2024

Autoimmune Diseases and Risk of Non-Hodgkin Lymphoma: A Mendelian Randomisation Study.

Cancer medicine
2024

Uncommon and Unusual Variants of Autoimmune Bullous Diseases.

Indian dermatology online journal
2024

Beyond the Gut: Exploring Cardiovascular Implications of Celiac Disease.

Cardiology in review
2024

Detection of autoantibodies to heat shock protein 70 in the saliva and urine of normal individuals.

Frontiers in immunology
2024

Facial Dermatitis Herpetiformis.

Skinmed
2024

Dapsone Use in Dermatology.

American journal of clinical dermatology
2024

Celiac Disease: A Forty-Year Analysis in an Italian Referral Center.

Nutrients
2024

Targeted serum proteome profiling reveals nicotinamide adenine dinucleotide phosphate (NADPH)-related biomarkers to discriminate linear IgA bullous disorder from dermatitis herpetiformis.

Clinical immunology (Orlando, Fla.)
2024

State-of-the-art diagnosis of autoimmune blistering diseases.

Frontiers in immunology
2024

Eczema herpeticum in an immunocompetent man.

Diagnostic microbiology and infectious disease
2024

A Critical Appraisal of Gluten in Skin Disorders, the Evidence So Far, and Updated Recommendations.

Indian journal of dermatology
2024

Pemphigus Herpetiformis: A Report of an Unusual Type of Pemphigus in a Three-Year-Old Female.

Cureus
2024

Sweet Syndrome as a Herpetiform Mimic: A Diagnostic Challenge.

The American Journal of dermatopathology
2024

Granular C3 dermatosis-A report of two cases and a mini-review of literature.

The Journal of dermatology
2024

[The disease under chronic urticaria: beyond itching].

Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
2024

Pruriginous vesicular eruption associated with nivolumab immunotherapy: A case of dermatitis herpetiformis.

Annales de dermatologie et de venereologie
2024

Diagnostic Utility of Direct Immunofluorescence on Paraffin-Embedded Skin Biopsy Samples for the Diagnosis of Autoimmune Vesiculobullous Lesions.

Cureus
2024

Navigating Food Allergies: Advances in Diagnosis and Treatment Strategies.

Cureus
2023

Epidemiological, Endoscopic, Clinical, and Pathological Features of Patients with Celiac Diseases in Southern Littoral of Caspian Sea.

Middle East journal of digestive diseases
2024

IgM-mediated epidermolysis bullosa acquisita.

JAAD case reports
2023

Rapid remission of severe impetigo herpetiformis following combined treatment with secukinumab and corticosteroids.

European journal of dermatology : EJD
2024

Celiac Disease-Related Conditions: Who to Test?

Gastroenterology
2024

The Need of Differential Diagnosis Between Vulvar Lichen Sclerosus and Autoimmune Dermatoses in Adolescent Girls.

Dermatology and therapy
2024

Immune-mediated oral mucosal pathology: a comprehensive review and update for clinicians - part II.

Italian journal of dermatology and venereology
2024

Improving the Diagnosis of Dermatitis Herpetiformis Using the Intraepithelial Lymphogram.

Nutrients
2023

Differences in the detection of circulating Hsp90 alpha between patients with atopic dermatitis and dermatitis herpetiformis.

Frontiers in medicine
2024

Systematic review with meta-analysis: Cause-specific and all-cause mortality trends across different coeliac disease phenotypes.

Alimentary pharmacology &amp; therapeutics
2023

Cutaneous Disorders Masking Celiac Disease: Case Report and Mini Review with Proposal for a Practical Clinical Approach.

Nutrients
2023

Epidemiological Study of Autoimmune Bullous Dermatoses in Northeastern Romania.

Diagnostics (Basel, Switzerland)
2023

Navigating the Challenges of Gluten Enteropathy and Infertility: The Role of Celiac-Related Antibodies and Dietary Changes.

Antibodies (Basel, Switzerland)
2023

Impetigo herpetiformis in the second trimester: a case report and review of the literature.

The Journal of international medical research
2023

Clinicopathological Profile of Dermatitis Herpetiformis Patients in Saudi Arabia.

Cureus
2023

Role of Human Leukocyte Antigen Class II in Antibody-Mediated Skin Disorders.

Medicina (Kaunas, Lithuania)
2023

Incidence of Dermatitis Herpetiformis in Sweden 2005 to 2018: A Nationwide Retrospective Cohort Study.

Acta dermato-venereologica
2022

[Trigger factors associated with bullous autoimmune dermatoses].

Dermatologie (Heidelberg, Germany)
2023

Immune-mediated oral mucosal pathology: a comprehensive review and update for clinicians. Part I.

Italian journal of dermatology and venereology
2022

[Dermatitis herpetiformis and other forms of wheat sensitivity].

Dermatologie (Heidelberg, Germany)
2023

Retrospective analysis of autoimmune bullous diseases in Middle Franconia.

Frontiers in immunology
2024

Could baricitinib be a safe and effective therapeutic alternative for incoercible pruritus in patients with dermatitis herpetiformis?

International journal of dermatology
2023

Autoantibody binding and unique enzyme-substrate intermediate conformation of human transglutaminase 3.

Nature communications
2023

Serum reactivity in dermatitis herpetiformis: an international multicentre study.

Clinical and experimental dermatology
2023

Gluten Intolerance and Its Association With Skin Disorders: A Narrative Review.

Cureus
2023

Exploring Celiac Disease: A Case Analysis of Multi-Systemic Symptoms and Effective Dietary Intervention in a Young Female.

Cureus
2023

Skin-Related Quality of Life During Autoimmune Bullous Disease Course.

JAMA dermatology
2024

Dipeptidyl peptidase-4 inhibitor-related pemphigus herpetiformis with antibodies against desmocollin 3.

The Journal of dermatology
2024

Gastrointestinal symptoms at diagnosis and during long-term gluten-free diet treatment in dermatitis herpetiformis patients.

Journal of the European Academy of Dermatology and Venereology : JEADV
2023

Patient-reported burden of skin disorders in coeliac disease.

Scandinavian journal of gastroenterology
2023

Separate Gut Plasma Cell Populations Produce Auto-Antibodies against Transglutaminase 2 and Transglutaminase 3 in Dermatitis Herpetiformis.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
2023

Risk of vascular diseases in patients with dermatitis herpetiformis and coeliac disease: a long-term cohort study.

Annals of medicine
2023

Skin gluten-related disorders: new and old cutaneous manifestations to be considered.

Frontiers in medicine
2023

Pemphigus foliaceus transforming into pemphigus herpetiformis.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
2023

JAK inhibitors for dermatitis herpetiformis: check the gut!

Dermatology online journal
2023

Pruritus Is Associated with an Increased Risk for the Diagnosis of Autoimmune Skin Blistering Diseases: A Propensity-Matched Global Study.

Biomolecules
2023

Computer-aided classification of indirect immunofluorescence patterns on esophagus and split skin for the detection of autoimmune dermatoses.

Frontiers in immunology
2023

A Rare Case of COVID-19-Induced Acute Exacerbation of Oral Dermatitis Herpetiformis in a Geriatric Patient.

International medical case reports journal
2023

Primate liver tissue substrate in indirect immunofluorescence diagnostics for patients with dermatitis herpetiformis and celiac disease.

Frontiers in immunology
2023

Atypical Dermatitis Herpetiform and Scalp Psoriasis in Ulcerative Colitis Patient Treated With Adalimumab.

Cureus
2022

Linear IgA bullous dermatosis of childhood.

Dermatology online journal
2023

Subclinical Celiac Disease Unmasked by Immune Checkpoint Inhibitor Therapy.

Journal of immunotherapy (Hagerstown, Md. : 1997)
2023

Immunopathological Assessment of the Oral Mucosa in Dermatitis Herpetiformis.

International journal of environmental research and public health
2022

An arcane presentation of pustular psoriasis in pregnancy: case report.

The Pan African medical journal
2022

From Chilblains (Pernio) to Coeliac Disease-Should We Still Consider It Random?

Children (Basel, Switzerland)
2023

High-grade B-cell lymphoma (HGBL)-NOS is clinicopathologically and genetically more similar to DLBCL/HGBL-DH than DLBCL.

Leukemia
2022

Defining the optimum strategy for identifying adults and children with coeliac disease: systematic review and economic modelling.

Health technology assessment (Winchester, England)
2022

Eczema herpeticum vs dermatitis herpetiformis as a clue of dedicator of cytokinesis 8 deficiency diagnosis: A case report.

World journal of clinical cases
2022

Dermatitis herpetiformis flare after excess ingestion of eggs.

JAAD case reports
2022

Rare Co-Existent Dermatitis Herpetiformis and Psoriasis in a Child: A Causal Relationship?

Cureus
2022

Acute femoral artery occlusion in a male with Duhring disease and COVID-19 pneumonia treated with baricitinib.

Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
2022

Dermatitis Herpetiformis With Flame Figures-An Unusual Case Description.

The American Journal of dermatopathology
2022

[Bullous autoimmune dermatoses of the mucous membranes].

Dermatologie (Heidelberg, Germany)
2023

Phenotypic Analysis of Disease-Relevant T Cells in Dermatitis Herpetiformis.

The Journal of investigative dermatology
2022

Bullous systemic lupus erythematosus in females.

International journal of women's dermatology
2022

Bullous Grover's Disease in a Chinese Tibetan Adolescent: A Case Report.

Clinical, cosmetic and investigational dermatology
2022

Urticarial dermatitis herpetiformis: A rare presentation of an uncommon disorder.

JAAD case reports
2022

Guidelines of the Italian societies of gastroenterology on the diagnosis and management of coeliac disease and dermatitis herpetiformis.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
2022

Histopathology of autoimmune bullous dermatoses: what's new?

Human pathology
2022

Current and Innovated Managements for Autoimmune Bullous Skin Disorders: An Overview.

Journal of clinical medicine
2022

A literature review on Janus kinase (JAK) inhibitors for the treatment of immunobullous disorders.

International immunopharmacology
2022

The risk of renal comorbidities in celiac disease patients depends on the phenotype of celiac disease.

Journal of internal medicine
2022

Serological Biomarkers and Their Detection in Autoimmune Bullous Skin Diseases.

Dermatology practical &amp; conceptual
2022

Sex-differences in Gluten-free Dietary Adherence and Clinical Symptoms in Patients with Long-term Treated Dermatitis Herpetiformis.

Acta dermato-venereologica
2022

Etiopathogenesis of dermatitis herpetiformis.

Postepy dermatologii i alergologii
2022

A case of pemphigus herpetiformis successfully treated with rituximab.

Journal of the European Academy of Dermatology and Venereology : JEADV
2023

Oral immune-mediated disorders with malignant potential/association: An overview.

Disease-a-month : DM
2022

Antibody Responses to Transglutaminase 3 in Dermatitis Herpetiformis: Lessons from Celiac Disease.

International journal of molecular sciences
2021

[Dermatitis herpetiformis and celiac disease].

Revista medica de Chile
2021

Analysis of FcαRI rs16986050 polymorphism in relation to autoimmune responses in dermatitis herpetiformis: an issue probing study.

Central-European journal of immunology
2022

Fibrillary "Fern-Like" Immunoglobulin A Deposition in Dermatitis Herpetiformis.

The American Journal of dermatopathology
2022

Clinical Treatment Study of Secondary Multiple Squamous Cell Carcinoma with Psoriasis Vulgaris.

Journal of oncology
2021

Association between celiac disease and vitiligo: A review of the literature.

World journal of clinical cases
2022

Diagnostics for Dermatologic Diseases with Autoantibodies.

The journal of applied laboratory medicine
2021

Diseases with oral manifestations among adult asthmatics in Finland: a population-based matched cohort study.

BMJ open
2022

Impetigo herpetiformis successfully treated with brodalumab.

The Journal of dermatology
2021

Acrodystrophic axonal polyneuropathy with celiac disease: a case report.

Journal of medical case reports
2021

THE MANAGEMENT OF DERMATITIS HERPETIFORMIS BY THE GASTROENTEROLOGIST. A SERIES OF CASES.

Arquivos de gastroenterologia
2022

Dermatitis herpetiformis triggered by iodine contrast media.

Journal of the European Academy of Dermatology and Venereology : JEADV
2021

The Gluten-Free Diet for Celiac Disease and Beyond.

Nutrients
2022

Dermatitis herpetiformis in a child with Wiskott-Aldrich syndrome: A rare occurrence.

Pediatric blood &amp; cancer
2022

Nutrition and bullous diseases.

Clinics in dermatology
2022

Recurrence of impetigo herpetiformis carrying compound heterozygous mutations in IL36RN after remission with secukinumab.

The Journal of dermatology
2019

Underlying coeliac disease in a case of cerebellar ataxia with unknown etiology.

Archive of clinical cases
2021

[Stiff person syndrome associated with dermatitis herpetiformis: a case report].

The Pan African medical journal
2021

Frequency of Cutaneous Disorders in Patients With Celiac Disease.

Cureus
2021

The accuracy of diagnostic indicators for coeliac disease: A systematic review and meta-analysis.

PloS one
2021

Skin Manifestations and Coeliac Disease in Paediatric Population.

Nutrients
2021

Assessment of Clinical and Laboratory Use of the Cutaneous Direct Immunofluorescence Assay.

JAMA dermatology
2021

Clinical Application of Pharmacogenetic Markers in the Treatment of Dermatologic Pathologies.

Pharmaceuticals (Basel, Switzerland)
2022

Role of nutritional supplements in selected dermatological disorders: A review.

Journal of cosmetic dermatology
2021

Persistent Skin Symptoms after Diagnosis and on a Long-term Gluten-free Diet in Dermatitis Herpetiformis.

Acta dermato-venereologica
2021

A Case of Possible Concurrence of Dermatitis Herpetiformis and Linear Immunoglobulin A / Immunoglobulin G Bullous Dermatosis.

Acta dermatovenerologica Croatica : ADC
2021

Evaluation of a Bi-Analyte Immunoblot as a Useful Tool for Diagnosing Dermatitis Herpetiformis.

Diagnostics (Basel, Switzerland)
2021

Dermatitis Herpetiformis: An Update on Diagnosis, Disease Monitoring, and Management.

Medicina (Kaunas, Lithuania)
2021

Significant improvement of dermatitis herpetiformis with tofacitinib.

Dermatology online journal
2021

Concurrent Dermatomyositis, Celiac Disease, and Dermatitis Herpetiformis in a Patient with a History of Morphea.

Kansas journal of medicine
2021

Tense blisters in a previously healthy young woman.

JAAD case reports
2021

Dermpath & Clinic: Pemphigus herpetiformis with vacuolar interface dermatitis and autoantibodies against desmoglein 1 and 3.

European journal of dermatology : EJD
2021

Refractory Pemphigus Herpetiformis in a Child Responsive to Intravenous Cyclophosphamide Pulse.

Skinmed
2021

The epidemiology of autoimmune bullous diseases in Sudan between 2000 and 2016.

PloS one
2021

[The many-faced gluten sensitivity: Gluten-induced autoimmunity from dermatological point of view].

Orvosi hetilap
2021

Morphological Spectrum of Vesiculobullous Skin Lesions: An Institutional Perspective.

Cureus
2022

Could it be gluten? Additional skin conditions associated with celiac disease.

International journal of dermatology
2021

Therapeutic approaches and targets for treatment of autoimmune bullous diseases.

Dermatologic therapy
2021

Fibrillar IgA staining - An uncommon finding in dermatitis herpetiformis.

Indian journal of dermatology, venereology and leprology
2021

S2k guidelines (consensus statement) for diagnosis and therapy of dermatitis herpetiformis initiated by the European Academy of Dermatology and Venereology (EADV).

Journal of the European Academy of Dermatology and Venereology : JEADV
2021

Evaluation of IgA epidermal transglutaminase ELISA in suspected dermatitis herpetiformis patients.

Dermatology online journal
2021

T Cell Response Toward Tissue-and Epidermal-Transglutaminases in Coeliac Disease Patients Developing Dermatitis Herpetiformis.

Frontiers in immunology
2021

Palmar petechiae in a patient with diabetes mellitus.

JAAD case reports
2021

Common variable immunodeficiency disclosed by recurrent impetigo.

The Journal of dermatology
2021

Educational Case: Dermatitis Herpetiformis.

Academic pathology
2021

Missing Insight Into T and B Cell Responses in Dermatitis Herpetiformis.

Frontiers in immunology
2021

In vitro diagnostics for the medical dermatologist. Part I: Autoimmune tests.

Journal of the American Academy of Dermatology
2021

Bullous Pemphigoid Mimicking Cellulitis.

Journal of investigative medicine high impact case reports
2021

Anaemia in Dermatitis Herpetiformis: Prevalence and Associated Factors at Diagnosis and One-year Follow-up.

Acta dermato-venereologica
2020

A Case of Dapsone-induced Mild Methemoglobinemia with Dyspnea and Cyanosis.

Acta dermatovenerologica Croatica : ADC
2021

Development of Dermatitis Herpetiformis in Chronic Plaque Psoriasis.

Case reports in dermatology
2021

EBV-positive Mucocutaneous Ulcer With Small Lymphocytic Infiltration Mimicking Nonspecific Ulceration.

The American journal of surgical pathology
2021

Subepithelial autoimmune blistering dermatoses: Clinical features and diagnosis.

Journal of the American Academy of Dermatology
2021

Subepithelial autoimmune bullous dermatoses disease activity assessment and therapy.

Journal of the American Academy of Dermatology
2021

A Case of Bullous Rash Apparently Triggered by Meningococcal and Rotavirus Vaccines in an Infant: Focus on Infantile Bullous Pemphigoid.

Dermatopathology (Basel, Switzerland)
2021

Research Supporting a Pilot Study of Metronomic Dapsone during Glioblastoma Chemoirradiation.

Medical sciences (Basel, Switzerland)
2021

Coeliac disease presenting atypically: A much wider spectrum.

Tropical doctor
2021

A novel quantitative ELISA as accurate and reproducible tool to detect epidermal transglutaminase antibodies in patients with Dermatitis Herpetiformis.

Journal of the European Academy of Dermatology and Venereology : JEADV
2021

Independent and cumulative coeliac disease-susceptibility loci are associated with distinct disease phenotypes.

Journal of human genetics
2021

Dermatitis Herpetiformis: An Update on Diagnosis and Management.

American journal of clinical dermatology
2021

Granular Deposits of IgA in the Skin of Coeliac Patients Without Dermatitis Herpetiformis: A Prospective Multicentric Analysis.

Acta dermato-venereologica
2022

Determinants and Trends of Adherence to a Gluten-Free Diet in Adult Celiac Patients on a Long-term Follow-up (2000-2020).

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
2021

T-Cell Response in Dermatitis Herpetiformis: May Epidermal Transglutaminase Play a Role in Predicting Clinical Relapse?

The Journal of investigative dermatology
2020

Grain Intake and Human Health.

Nutrients
2021

Recalcitrant dermatitis herpetiformis treated successfully with sulfasalazine.

International journal of dermatology
2020

[PUSTULAR PSORIASIS DURING PREGNANCY: WHEN IS THE RIGHT TIME TO DELIVER?].

Harefuah
2020

Non infective bullous lesions: a diagnostic challenge in a minimally equipped centre- based solely on microscopic findings.

African health sciences
2021

Risk of skin disorders in patients with celiac disease: A population-based cohort study.

Journal of the American Academy of Dermatology
2020

Free perforation of primary small bowel lymphoma in a patient with celiac sprue and dermatitis herpetiformis.

Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma &amp; emergency surgery : TJTES
2020

Autoantibodies Against the Immunodominant Bullous Pemphigoid Epitopes Are Rare in Patients With Dermatitis Herpetiformis and Coeliac Disease.

Frontiers in immunology
Ver todos os 1.552 no EuropePMC

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Doenças relacionadas

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Cohort study of neurological and psychiatric morbidity in dermatitis herpetiformis and celiac disease.
    Scandinavian journal of gastroenterology· 2026· PMID 41761874mais citado
  2. European S2k guidelines on management of autoimmune blistering diseases in children and adolescents.
    Journal of the European Academy of Dermatology and Venereology : JEADV· 2026· PMID 41678328mais citado
  3. From photosensitivity to autoimmunity: the role of AI metabolomics in PCT-celiac disease overlap.
    Annals of medicine and surgery (2012)· 2026· PMID 41675771mais citado
  4. A systematic review of therapeutic and paradoxical roles of tumor necrosis factor &#x3b1; inhibitors in autoimmune blistering diseases.
    Inflammopharmacology· 2026· PMID 41396376mais citado
  5. Dapsone use in dermatology: indication, efficacy and tolerability experience of a UK tertiary dermatology department.
    Clinical and experimental dermatology· 2026· PMID 41134709mais citado
  6. Diagnosis of Autoimmune Blistering Diseases: Dermatopathology and Other Laboratory Updates.
    Dermatol Clin· 2026· PMID 41951330recente
  7. Beyond the codes: radiological and neurosensorial nuances in the celiac-dermatitis herpetiformis spectrum.
    Scand J Gastroenterol· 2026· PMID 41910029recente
  8. Isolated Hand Involvement as the Presenting Sign of Dermatitis Herpetiformis.
    J Clin Aesthet Dermatol· 2026· PMID 41890778recente
  9. Multifocal motor neuropathy secondary to gluten intolerance: a case report.
    J Med Case Rep· 2026· PMID 41888964recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:1656(Orphanet)
  2. MONDO:0015614(MONDO)
  3. GARD:10075(GARD (NIH))
  4. Busca completa no PubMed(PubMed)
  5. Artigo Wikipedia(Wikipedia)
  6. Q1151507(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Dermatite herpetiforme
Compêndio · Raras BR

Dermatite herpetiforme

ORPHA:1656 · MONDO:0015614
Prevalência
1-5 / 10 000
Herança
Not applicable
CID-10
L13.0 · Dermatite herpetiforme
CID-11
Ensaios
2 ativos
Início
All ages
Prevalência
27.0 (Europe)
MedGen
UMLS
C0011608
Repurposing
9 candidatos
adelmidrolanti-inflammatory agent
clobetasone-butyratecorticosteroid agonist
crisaborolephosphodiesterase inhibitor
+6 outros
EuropePMC
Wikidata
Wikipedia
Papers 10a
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