A síndrome DRESS (Drug Rash with Eosinophilia and Systemic Sintomas) é uma reação de hipersensibilidade caracterizada por erupção cutânea generalizada, febre, eosinofilia, linfocitose e envolvimento visceral (hepatite, nefrite, pneumonite, pericardite e miocardite) e, em alguns pacientes, reativação do vírus do herpes humano 6.
Introdução
O que você precisa saber de cara
A síndrome DRESS (Drug Rash with Eosinophilia and Systemic Sintomas) é uma reação de hipersensibilidade caracterizada por erupção cutânea generalizada, febre, eosinofilia, linfocitose e envolvimento visceral (hepatite, nefrite, pneumonite, pericardite e miocardite) e, em alguns pacientes, reativação do vírus do herpes humano 6.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 7 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 28 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
Triagem neonatal (Teste do Pezinho)
A triagem neonatal permite diagnóstico precoce e início imediato do tratamento.
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Nenhum gene associado encontrado
Os dados genéticos desta condição ainda estão sendo catalogados.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Reação medicamentosa com eosinofilia e sintomas sistêmicos
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Ensaios em destaque
Pesquisa e ensaios clínicos
9 ensaios clínicos encontrados.
Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 1.167
Correction: The Hidden Perils of Allopurinol: A Systematic Review of Allopurinol-Induced DRESS (Drug Reaction With Eosinophilia and Systemic Symptoms) Syndrome.
[This corrects the article DOI: 10.7759/cureus.104474.].
The Hidden Perils of Allopurinol: A Systematic Review of Allopurinol-Induced DRESS (Drug Reaction With Eosinophilia and Systemic Symptoms) Syndrome.
Drug hypersensitivity reactions are a clinically significant and potentially preventable cause of hospital admission, treatment interruption, and drug-related mortality worldwide. Within severe cutaneous adverse reactions (SCARs), a group that includes Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS), DRESS stands out because of its delayed onset, multi-organ involvement, and frequent diagnostic uncertainty. Allopurinol is a commonly prescribed medication for hyperuricemia, but in rare cases, it can trigger DRESS. This systematic review was conducted to comprehensively summarize the demographic characteristics, clinical manifestations, diagnostic features, management strategies, and outcomes of reported cases of allopurinol-induced DRESS syndrome. Available case reports and case series were analyzed to consolidate patient characteristics, patterns of organ involvement, treatment approaches, and clinical outcomes. The findings indicate that allopurinol-induced DRESS most often presents with cutaneous manifestations and systemic involvement, most commonly affecting the liver and kidneys, and is associated with considerable morbidity and mortality despite treatment. These results emphasize the importance of early recognition, prompt drug discontinuation, and cautious prescribing of allopurinol, particularly in high-risk populations.
A case of steroid-induced mania following lamotrigine-induced drug reaction with eosinophilia and systemic symptoms (DRESS): a cautionary tale.
Drug reaction with eosinophilia and systemic symptoms is a severe cutaneous adverse reaction frequently associated with lamotrigine, an antiepileptic drug also used to treat bipolar disorder. Although a mainstay of therapy for drug reaction with eosinophilia and systemic symptoms is oral corticosteroids, steroids should be used with caution in patients with bipolar disorder, as mania is a well-known drug side effect. We present a case of a 21-year-old female patient with bipolar disorder who was treated with prednisone for lamotrigine-induced drug reaction with eosinophilia and systemic symptoms, and subsequently experienced steroid-induced mania, exacerbated by an unopposed antidepressant medication. This resulted in involuntary hospital admission under psychiatry, which was profoundly distressing for the patient. We present this case as a reminder to screen for risk of mania in patients receiving systemic corticosteroids, and to carefully assess concurrent antidepressant use when discontinuing mood stabilizers like lamotrigine.
Tofacitinib Rescue for Refractory Drug-Induced Liver Injury With Severe DRESS: A Prospective Proof-of-Concept Study.
Drug-induced liver injury (DILI) with severe DRESS carries high mortality, yet rescue therapies for corticosteroid-refractory cases remain undefined. We hypothesized that JAK inhibition could reverse refractory liver injury by targeting the underlying cytokine storm. In this prospective proof-of-concept study, consecutive patients with severe DRESS-associated DILI refractory to corticosteroids (persistent/worsening liver injury) received oral tofacitinib rescue. Key assessments were the normalisation of liver biochemistries. Despite initial corticosteroids, all four patients exhibited progressive severe injury (median peak ALT 1126 U/L). Tofacitinib rapidly reversed liver injury in all cases. Transaminases normalised or near-normalised (median: 48 days), total bilirubin normalised, and cutaneous symptoms resolved completely. Notably, baseline positive autoantibodies seroconverted to negative. No severe adverse events occurred (median follow-up: 274 days). Tofacitinib shows promise as a rescue strategy for corticosteroid-refractory DILI with severe DRESS. The rapid recovery underscores the JAK-STAT pathway's pathogenic role in this setting.
A Diagnostic Pitfall: Carbamazepine-Induced Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome Masquerading As Angiotensin-Converting Enzyme Inhibitor Angioedema.
Drug reaction with eosinophilia and systemic symptoms (DRESS), also known as drug-induced hypersensitivity syndrome (DIHS), is a severe, multiorgan, delayed hypersensitivity reaction with significant morbidity. Diagnosis is often delayed due to its mimicry of other conditions. We present the case of a 69-year-old Hispanic male with hypertension and stage two chronic kidney disease who developed trigeminal neuralgia and was started on carbamazepine. Approximately seven weeks later, he presented with a generalized rash, angioedema, and mucosal swelling, initially attributed to his concurrent lisinopril therapy. Despite discontinuation of lisinopril and treatment with corticosteroids and antihistamines, his condition progressed with new systemic symptoms, including paresthesia, dysgeusia, polydipsia, polyuria, and weight loss. The progression of symptoms despite this intervention was the pivotal diagnostic clue. Hospital admission revealed marked eosinophilia (8.9 percent), mild transaminitis, and a diffuse erythrodermic rash involving more than 90 percent of his body surface area. A diagnosis of probable DRESS syndrome (RegiSCAR score six) secondary to carbamazepine was made. Immediate discontinuation of carbamazepine and initiation of intravenous corticosteroids led to rapid clinical and laboratory improvement. He was discharged on a prolonged oral steroid taper with complete resolution at follow-up. This case underscores the critical importance of considering DRESS in any patient with a rash and systemic symptoms occurring two to eight weeks after initiation of a high-risk drug, even in the presence of other potential culprits. It highlights that clinical progression despite withdrawal of one suspected agent should prompt urgent re-evaluation for an alternative etiology, such as DRESS.
Publicações recentes
Pediatric Severe Cutaneous Adverse Drug Reactions (SCARs) clinical characteristics and comparison of causality assesment tools and severity scoring systems in relation to clinical outcomes from a single center experience.
Pulmonary infiltrates as part of drug reaction with eosinophilia and systemic symptoms syndrome in a patient with pulmonary tuberculosis: a clinical conundrum.
Pembrolizumab and Nivolumab-Induced Late Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS): A Case Report.
Antiepileptic Drug-Induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): A Case Series.
Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome Following Carbamazepine Use in a Young Male With Psychiatric Comorbidities.
📚 EuropePMC679 artigos no totalmostrando 194
The Hidden Perils of Allopurinol: A Systematic Review of Allopurinol-Induced DRESS (Drug Reaction With Eosinophilia and Systemic Symptoms) Syndrome.
CureusA case of steroid-induced mania following lamotrigine-induced drug reaction with eosinophilia and systemic symptoms (DRESS): a cautionary tale.
SAGE open medical case reportsTofacitinib Rescue for Refractory Drug-Induced Liver Injury With Severe DRESS: A Prospective Proof-of-Concept Study.
Liver international : official journal of the International Association for the Study of the LiverA Diagnostic Pitfall: Carbamazepine-Induced Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome Masquerading As Angiotensin-Converting Enzyme Inhibitor Angioedema.
CureusPrioritization of adverse events related to integrase inhibitors and NNRTIs: a disproportionality analysis using data from the FAERS database.
The Journal of antimicrobial chemotherapyHematologic Patterns in Differentiating DRESS From Morbilliform Drug Eruptions: A Preliminary Investigation.
Dermatitis : contact, atopic, occupational, drugSoluble Fas Ligand, an overlooked target of therapy in dermatological and non-dermatological conditions.
The Journal of dermatological treatmentClopidogrel-induced drug-induced hypersensitivity syndrome following percutaneous coronary intervention: a case report of therapeutic dilemma and management strategy.
Frontiers in pharmacologyDrug Reaction with Eosinophilia and Systemic Symptoms in the Electronic Medical Record.
International archives of allergy and immunologyInsights into Severe Cutaneous Adverse Drug Reactions: A 5-Year Retrospective Analysis of Stevens- Johnson Syndrome- Toxic Epidermal Necrolysis and Drug Rash with Eosinophilia and Systemic Symptoms.
Indian dermatology online journal[Drug-induced hypersensitivity reactions : Pulmonary manifestations and radiological characteristics].
Radiologie (Heidelberg, Germany)Severe DRESS syndrome with hemophagocytic lymphohistiocytosis and cryptococcal meningitis: a case report and diagnostic challenge.
Frontiers in immunologyPossible drug reaction with eosinophilia and systemic symptoms after spironolactone therapy for clinical hyperandrogenism: a case report.
F&S reportsDouble Jeopardy: Lamotrigine-Induced Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Complicated by Valproate Hepatotoxicity.
CureusRacial Disparities in Severe Cutaneous Adverse Reactions: A Report of Two Cases on Preventable Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Prescription Errors Through Medication Stewardship.
CureusJAK1 or JAK1/2 inhibitors in Drug Reaction with Eosinophilia and Systemic Symptoms: A case series.
Clinical and experimental dermatologyNavigating a Dual Hyperinflammatory State: Overlap of Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) and Secondary Hemophagocytic Lymphohistiocytosis (HLH) in a Child.
CureusCyclosporine use in paediatric dermatologic conditions: A comprehensive review of therapeutic applications.
British journal of clinical pharmacologyBaricitinib for traditional Chinese medicine-induced drug reaction with eosinophilia and systemic symptoms: a case report.
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDGAtypical presentation of DRESS/DiHS mimicking an acquired ichthyosis: A case report of bortezomib-induced severe erythroderma in multiple myeloma.
SAGE open medical case reportsReal-World Data on Severe Cutaneous Adverse Reactions to Drugs.
Pharmaceuticals (Basel, Switzerland)Clinical and prognostic implications of erythema multiforme-like lesions in patients with DRESS: A prospective case-control study.
Clinical and experimental dermatologySymptomatic Hypercalcemia with Vomiting in a Pediatric Patient with Graves' Disease.
Journal of clinical research in pediatric endocrinologyAllopurinol-induced drug reaction with eosinophilia and systemic symptoms syndrome in a patient with previous nephrectomy: a case report.
Journal of medical case reportsDrug Reaction with Eosinophilia and Systemic Symptoms Following Antibiotic Cement Spacer Placement: A Case Report.
JBJS case connectorSevere cutaneous adverse drug reactions due to antituberculosis drugs and their management.
Northern clinics of IstanbulA Complex Diagnostic Challenge of Dual Antibiotic-Induced Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome With Multiorgan Involvement.
CureusDrug Reaction With Eosinophilia and Systemic Symptoms Syndrome Induced by Abiraterone: Evidence From a Positive Rechallenge.
American journal of therapeuticsDrug Reaction With Eosinophilia and Systemic Symptoms (DRESS Syndrome) Manifesting With Pseudolymphoma Multisystemic Organ Involvement.
Clinical case reportsAntibiotic-Associated Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) in a Young Male: A Case Report of Recurrence Without Organ Involvement.
CureusGemcitabine-Induced Drug Rash With Eosinophilia and Systemic Symptoms (DRESS Syndrome): A Case Report.
CureusCefadroxil-Induced Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome After Double Mastectomy for Ductal Carcinoma In Situ: A Case Report.
CureusDRESS syndrome in a patient with rheumatoid arthritis: Navigating the intersection of drug-induced hypersensitivity and immune-mediated inflammation.
BMJ case reportsMycoplasma Rash With Eosinophilia and Systemic Symptoms: A Report of Two Cases.
Pediatric dermatologyCorrigendum to: A Rare Clinical Course in Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome: Lung Involvement.
Pediatric allergy, immunology, and pulmonologySuccessful evaluation and management of insulin hypersensitivity reactions.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & ImmunologyCheilitis: a comprehensive review and a new clinical classification proposal. Part 1: Isolated cheilitis.
Italian journal of dermatology and venereologyExamination of HLA-DRB1*15-linked Candidate Antigens in Still Disease With and Without Lung Disease and Drug-Associated Immune Reactions.
The Journal of rheumatologyDRESS (Drug Reaction With Eosinophilia and Systemic Symptoms) Is More: A Rare Case of Acalculous Cholecystitis.
ACG case reports journalAssociation between human herpesvirus reactivations and the severity of maculopapular exanthema and drug reaction with eosinophilia and systemic symptoms: a retrospective comparative study.
The British journal of dermatologyComparative safety profile of levofloxacin versus moxifloxacin in first-line tuberculosis therapy: a pharmacovigilance study of the FAERS database.
Frontiers in pharmacologyRegarding "Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Induced by Meropenem in a Patient Receiving Avelumab and Subsequent Flare-up".
Journal of investigational allergology & clinical immunologySevere cutaneous adverse reactions linked to medications in children and adolescents: a pharmacovigilance study based on the FDA Adverse Event Reporting System database.
International journal of clinical pharmacyIncidence and clinical patterns, severity and preventability of cutaneous adverse drug reactions among hospitalized patients in a tertiary centre.
The Medical journal of MalaysiaDRESS Syndrome Mimicking Postoperative Cholestasis: A Case Report.
Clinical medicine insights. Case reportsDrug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome Caused by Pola-R-CHOP: A Case Report.
CureusA pharmacovigilance study of daptomycin use in infants under 1 year old based on the FDA adverse event reporting system.
Scientific reportsCase Report: Praziquantel-induced flare-up reaction in a rare case of diclofenac-induced probable DRESS comorbid with acute clonorchiasis: diagnostic and therapeutic challenges.
Frontiers in medicineDrug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Due to Trimethoprim: A Case Report.
CureusDRESS syndrome with cerebral vasculitis provoked by piperacillin/tazobactam: a case report.
Acta neurologica BelgicaSkin-adverse drug reactions in the elderly: An underestimated and avoidable issue.
Annales de dermatologie et de venereologiePrevalence and patient-level factors associated with common antibiotic allergy labels among patients undergoing hematopoietic stem cell transplants: a cross-sectional study.
The journal of allergy and clinical immunology. In practiceHLA-B*58:01 and Risk of Allopurinol-Induced Severe Cutaneous Adverse Reactions in the US.
JAMA dermatologyPostoperative Staphylococcal Toxic Shock Syndrome in a Patient Following Right Knee Fracture Repair: A Case Report.
CureusA Case of Drug-Induced Lung Injury With Systemic Features Resembling DRESS Caused by Saiko-Ka-Ryukotsu-Borei-To and Goreisan.
Respirology case reportsCotrimoxazole-Induced Drug-Induced Hypersensitivity Syndrome/Drug Reaction With Eosinophilia and Systemic Symptoms With Persistent Human Herpesvirus-6 DNA Detection and Flare Without Elevated TARC Levels.
The Journal of dermatologyHuman Herpesvirus 6 in Acute Liver Failure: Leading Role, Supporting Actor or Innocent Bystander? A Case Series, Narrative Review and Management Algorithm Proposal.
Journal of viral hepatitisBiologic therapies for dermatologic emergencies: A comprehensive review.
Journal of the American Academy of DermatologyUndressing DReSS as p-i mediated disease.
Allergology international : official journal of the Japanese Society of AllergologyEosinophilic Myocarditis Treated with IL-5 Blockade: An Integrated Case Report and Literature Review.
Journal of clinical medicineAn infant with drug reaction with eosinophilia and systemic symptoms caused by phenobarbital and amoxicillin: A case report.
MedicineMinocycline-induced DRESS: could dosage in relation to body fat mass be a contributing factor?
Frontiers in pharmacologySuccessful Management of Oxacillin-Induced Eosinophilic Myocarditis and Review of the Literature.
JACC. Case reportsDrug Reaction with Eosinophilia and Systemic Symptoms Secondary to Ethambutol.
Journal of Brown hospital medicineSulfasalazine-Induced Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome in a Patient With Rheumatoid Arthritis.
CureusA Preventable Adverse Reaction: Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome Following Allopurinol Use for Asymptomatic Hyperuricemia.
CureusClindamycin-Induced Dermatitis and the Sparing Phenomenon: A Case Report.
CureusDrug Reaction with Eosinophilia and Systemic Symptoms (DRESS) caused by niraparib: a novel antineoplastic agent.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology[DRESS syndrome associated with levetiracetam use in a pediatric patient. A case report].
Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)[Diosmin-hesperidin-induced DRESS syndrome: immune reactivation by herpesvirus].
Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)Association of HLA-B*53 With DRESS Syndrome in Patients Treated With Raltegravir: Two Case Reports and a Literature Review.
Basic & clinical pharmacology & toxicologyCarbamazepine-Induced Drug Rash With Eosinophilia and Systemic Symptoms (DRESS) Syndrome.
CureusCase series: Drug reaction with eosinophilia and systemic symptoms (DRESS).
Tropical doctorLong-term morbidity and quality of life in survivors of Stevens-Johnson syndrome/toxic epidermal necrolysis spectrum.
The British journal of dermatologySevere Cutaneous Adverse Reaction to Intraperitoneal Vancomycin: A Case of DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms) Syndrome.
CureusRucaparib-Associated Drug Reaction With Eosinophilia and Systemic Symptoms Syndrome.
CureusThe association of class II HLA alleles with tuberculosis-associated immune reconstitution inflammatory syndrome.
PLoS pathogensDrug reaction with eosinophilia and systemic symptoms syndrome in association with novel antineoplastic pharmacotherapy: Characterizing reported clinical patterns and outcomes utilizing the Food and Drug Administration Adverse Event Reporting System database.
Journal of the American Academy of DermatologyEmapalumab for Maladaptive Interferon-γ-Mediated Inflammation in Drug Reaction With Eosinophilia and Systemic Symptoms Complicating First-Line Antituberculosis Therapy.
Pediatric blood & cancerSummary of the 12th International Conference on Human Herpesviruses-6A, -6B, and -7.
Journal of medical virologyDrug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Following Conversion Surgery for Esophageal Cancer: A Case Report.
CureusAfebrile vancomycin-induced delayed hypersensitivity suggestive of incomplete drug rash with eosinophilia and systemic symptoms syndrome: a case report.
Journal of medical case reportsSeasonality and Trends in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Before and During the COVID-19 Pandemic: A Pharmacovigilance Study.
medRxiv : the preprint server for health sciencesA Rare Clinical Course in Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome: Lung Involvement.
Pediatric allergy, immunology, and pulmonologyLong-Term Safety of Anti-Interleukin-1 Medications in Children with Rheumatic Diseases: a Systematic Review.
Paediatric drugsThe role of skin testing, drug challenge and IFN-γ ELISpot in delayed hypersensitivity to iodinated contrast media.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical ImmunologyAtypical lymphoid proliferations associated with therapeutic intervention: a report of the 2024 EA4HP/SH lymphoma workshop.
Virchows Archiv : an international journal of pathologyDifferentiating between a prasugrel-induced hypersensitivity reaction and an atorvastatin-induced DRESS syndrome in the post-percutaneous coronary intervention setting.
JAAD case reportsHLA-B Alleles With Shared Peptide Binding Specificities Define Global Risk of Co-trimoxazole-Induced Severe Cutaneous Adverse Drug Reactions.
The journal of allergy and clinical immunology. In practiceClinical manifestations, diagnostic criteria, and treatment outcomes of minocycline-associated DRESS syndrome: a comprehensive exploration of published cases.
Frontiers in pharmacologyAcute Kava (Piper Methysticum) Dermatitis With Drug Reaction With Eosinophilia and Systemic Symptoms-Like Features and Sebotropic Inflammation: A Case Series.
The American Journal of dermatopathologyAnaphylaxis to Penicillin: Harvesting Insights From the Food and Drug Administration's Adverse Event Reporting System.
The journal of allergy and clinical immunology. In practiceDrug Provocation Testing in Allergological Work-Up of DRESS: A Retrospective Real-Life Experience From a Specialist Centre.
Contact dermatitisSevere cutaneous adverse reactions associated with novel antiandrogens: A disproportionality analysis of three databases.
International journal of cancerBenralizumab in Corticosteroid-Refractory Drug Reaction With Eosinophilia and Systemic Symptoms: A Case Report.
CureusA Case of Allopurinol-Induced Drug Reaction with Eosinophilia and Systemic Symptoms in a Patient With Polycystic Kidney Disease and Chronic Kidney Disease.
WMJ : official publication of the State Medical Society of WisconsinEmpagliflozin-related DRESS syndrome.
European heart journal. Case reportsDevelopment and validation of prognostic models using novel inflammatory markers for drug reactions with eosinophilia and systemic symptoms: An international multicenter cohort study.
Journal of the American Academy of DermatologyImmune Checkpoint Inhibitors as Independent and Synergistic Drivers of SJS/TEN: An Analysis of FAERS.
medRxiv : the preprint server for health sciencesSafety of Proton Pump Inhibitor in Paediatrics: A Study Based on EudraVigilance Data.
Fundamental & clinical pharmacologyX-linked lymphoproliferative syndrome type 1 presenting as DRESS-HLH overlap syndrome.
BMJ case reportsDrug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Induced by Meropenem in a Patient Receiving Avelumab and Subsequent Flare-Up.
Journal of investigational allergology & clinical immunologyClinical diagnosis and management of drug reaction with eosinophilia and systemic symptoms (DRESS) in children: An EAACI position paper.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and ImmunologyCarbamazepine-induced acute pancreatitis: rare manifestation of drug reaction with eosinophilia and systemic symptoms syndrome.
BMJ case reportsA cross-sectional analysis of inflammatory markers as a severity and prognostic indicator in severe cutaneous adverse drug reactions.
Indian journal of dermatology, venereology and leprology[DRESS syndrome due to antituberculosis drugs. Review and comments].
MedicinaDeciphering Immune Endotypes Within Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome.
AllergyDrug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome Following Initiation of Sulfasalazine for Ulcerative Colitis: A Yearlong Clinical Challenge.
Case reports in gastrointestinal medicineManagement of patients with tuberculosis medication-induced drug reaction with eosinophilia and systemic symptoms.
Current opinion in allergy and clinical immunologyCarbamazepine-Induced DRESS Syndrome During Epstein-Barr Virus Reactivation in an Adolescent.
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAGStandardization of Electronic Medical Record Documentation Improves Hospitalist Communication in Drug Reaction With Eosinophilia and Systemic Symptoms.
International journal of dermatologyCo-Sensitization After Single-Dose Antibiotic Exposure During Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS): The Role of Repeat Drug Patch Testing.
Contact dermatitisDrug Reaction With Eosinophilia and Systemic Symptoms in Children.
JAMA dermatologyDrug reaction with eosinophilia and systemic symptoms (DRESS)with anti-tuberculosis drugs, a rare and serious complication.
Dermatology online journalAccelerated Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome in Response to TMP-SMX: A Case Report.
The American journal of case reportsImmune phenotyping impacts on management of severe cutaneous adverse reaction.
Current opinion in allergy and clinical immunologyDRESS Syndrome in Patients With Drug-Induced Liver Injury: Characteristics and HLA Risk Factors.
The American journal of gastroenterologyHLA-B Alleles with Shared Peptide Binding Specificities Define Global Risk of Cotrimoxazole-induced SCAR.
medRxiv : the preprint server for health sciencesDRESS syndrome secondary to phenytoin: a case report and review of the literature.
Annals of medicine and surgery (2012)Concurrent acute interstitial nephritis with acute pyelonephritis in DRESS syndrome: a rare case report.
Annals of medicine and surgery (2012)Updates in the pathogenesis of SJS/TEN.
Allergology international : official journal of the Japanese Society of AllergologyDRESS Syndrome with Cold Agglutinins: An Unusual Immune Response to Anticonvulsants.
Current drug safetyPD-1 monoclonal antibody (Tislelizumab)-induced DRESS syndrome in an intrahepatic cholangiocarcinoma patient with FGFR3 mutation and elevated IgG4:A case report.
Clinical immunology (Orlando, Fla.)Rapid-onset drug reaction with eosinophilia and systemic symptoms (DReSS) in children: a scoping review.
Archives of dermatological researchSafety of sulfamethoxazole-trimethoprim for the treatment of bacterial infection in outpatient settings: A systematic review and meta-analysis with active comparator disproportionality analysis.
British journal of clinical pharmacologyDrug Reaction With Eosinophilia and Systemic Symptoms and Severe Drug-Induced Liver Injury After Off-Label Zonisamide Use for Weight Loss.
ACG case reports journalElucidating CD4+ and CD8+ T-cell involvement in patients with vancomycin-induced DRESS.
Toxicological sciences : an official journal of the Society of ToxicologyVancomycin-Induced DRESS Syndrome: A Systematic Review of Case Reports.
Hospital pharmacySpecific clinical features define HLA-A∗32:01-positive vancomycin drug reaction with eosinophilia and systemic symptoms: A multi-institution cross-sectional study.
The journal of allergy and clinical immunology. In practiceFrench national protocol for diagnosis and management of drug reaction with eosinophilia and systemic symptoms (DRESS) in adults and children.
Annales de dermatologie et de venereologieApalutamide-Induced Drug-Induced Hypersensitivity Syndrome/Drug Reaction With Eosinophilia and Systemic Symptoms Involving Reactivation of Human Herpesvirus-6 and Cytomegalovirus: A Case Report.
The Journal of dermatologyJanus kinase inhibitors in pediatric patients with corticosteroid-resistant drug reaction with eosinophilia and systemic symptoms.
The journal of allergy and clinical immunology. In practiceLady in Red: A Fatal Case of Drug Reaction With Eosinophilia and Systemic Symptoms.
CureusDrug reaction with eosinophilia and systemic symptoms.
Internal and emergency medicineOlanzapine-induced Drug Reaction with Eosinophilia and Systemic Symptoms: Case Report and Review of the Literature.
Acta dermato-venereologicaMental health and psychosocial outcomes in survivors of severe cutaneous adverse reactions: a scoping review.
Clinical and experimental dermatologyDRESS syndrome presenting with acute hypoxic respiratory failure and delayed eosinophilia.
BMJ case reportsAbrocitinib in the Treatment of Drug Reaction With Eosinophilia and Systemic Symptoms.
American journal of therapeuticsCarbamazepine-Induced DRESS Complicated by HLH and VBDS: A Case Report.
Journal of asthma and allergyDrug Reaction with Eosinophilia and Systemic Symptoms Syndrome following Dalbavancin and Oritavancin Administration in a Patient with Osteomyelitis.
Case reports in dermatologyLow-dose venlafaxine-induced erythema multiforme: a case report.
Journal of medical case reportsRecent advances in the diagnosis and treatment of DIHS/DRESS in 2025.
Allergology international : official journal of the Japanese Society of AllergologyIL-5 Inhibitor Treatment in Drug Reaction With Eosinophilia and Systemic Symptoms.
JAMA dermatologyGabapentin for refractory pruritus in severe cutaneous adverse reactions.
JAAD case reportsAtrial standstill due to eosinophilic myocarditis and drug reaction with eosinophilia and systemic symptoms.
HeartRhythm case reportsComparing immunopathogenesis of non-human immunodeficiency virus immune reconstitution inflammatory syndrome and immune-related adverse events: A prospective multicenter cohort study.
The Journal of dermatology[Hot Topics 2024 and 2025 in dermatology].
Revue medicale suisseAntibiotics and Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome: Analysis of Brazilian Pharmacovigilance Registries.
Pharmacoepidemiology and drug safetyHistopathologic Features in Vancomycin-Associated Drug-Induced Hypersensitivity Syndrome.
Journal of cutaneous pathology[Dermatological conditions requiring intensive care treatment].
Dermatologie (Heidelberg, Germany)An unusually severe case of shiitake mushroom dermatitis with features of drug reaction with eosinophilia and systemic symptoms.
Skin health and diseaseDemographics, Overlap, and Latency of Severe Cutaneous Adverse Reactions in an FDA Database.
medRxiv : the preprint server for health sciencesDecoding Beta-Lactam Cross-Reactivity - Longitudinal Patch Testing From 2000 to 2022.
Contact dermatitisRecommendations on how to proceed in case of suspected allergy to penicillin/β-lactam antibiotics: Position paper of the German Society for Allergology and Clinical Immunology (DGAKI) in cooperation with the German Society for Pediatric Allergology (GPA), Austrian Society for Allergology and Immunology (ÖGAI) and the Swiss Society for Allergology and Immunology (SGAI).
Allergologie selectSevere Hypersensitivity Reactions with Oral Manifestations: Case Reports on Stevens-Johnson Syndrome and DRESS Syndrome.
Journal of pharmacy & bioallied sciencesDrug Reaction with Eosinophilia and Systemic Symptoms (DRESS): A Retrospective Study of 51 Chinese Patients.
Clinical, cosmetic and investigational dermatologyHypereosinophilic Syndrome in a Patient With Complex Pulmonary Hypertension and Sjogren's Syndrome: A Case Report.
CureusWhen Treatment Backfires: A Case Report of Sulfasalazine-Induced Hypersensitivity Syndrome in a Moroccan Patient With Crohn's Disease and Literature Review.
CureusDiagnosing and Managing Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Amidst Remaining Uncertainty.
The journal of allergy and clinical immunology. In practiceRapid drug desensitization in seven patients with delayed hypersensitivity reactions to biologics and targeted therapies: Reason, successes, and failures.
Allergy and asthma proceedingsDrug Reaction with Eosinophilia and Systemic Symptoms. Reply.
The New England journal of medicineTreatment of Cutaneous Neurofibromas in Neurofibromatosis Type 1 With MEK Inhibitor Selumetinib: A Nonrandomized Clinical Trial.
JAMA dermatologySingle-cell immunopathology of recurrent acute generalized exanthematous pustulosis associated with vancomycin.
The journal of allergy and clinical immunology. GlobalSevere Cutaneous Adverse Reactions Associated with Immune Checkpoint Inhibitors: A Systematic Review of Clinical Characteristics and Management.
Journal of cutaneous medicine and surgerySevere Cutaneous Adverse Reactions Following Vaccination: A Systematic Review and Meta-Analysis.
The journal of allergy and clinical immunology. In practiceA Diagnostic Dilemma: Daptomycin-Induced Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome and Eosinophilic Pneumonia With Concurrent COVID-19.
Cureus[Exanthematic drug eruption].
Pathologie (Heidelberg, Germany)Assessment of adverse events of the novel antiepileptic drug lamotrigine: a real-world pharmacovigilance study based on FAERS.
Expert opinion on drug safetyDrug reaction with eosinophilia and systemic symptoms induced by paclitaxel, a rare combination.
British journal of clinical pharmacologyPediatric drug reaction with eosinophilia and systemic symptoms: Pharmacovigilance and prognosis.
Journal of the American Academy of DermatologyImpact of non-genetic factors on severe cutaneous adverse reactions and associated mortality in ESRD patients: Advancing clinical guidance.
The American journal of the medical sciencesVancomycin Drug Reaction with Eosinophilia and Systemic Symptoms: Meta-Analysis and Pharmacovigilance Study.
Journal of clinical medicineAn Adverse Double-Hit by Pembrolizumab: A Case Report of Bullous Pemphigoid and Pneumonitis.
Journal of medical cases[Cas n#1. Drug reaction with eosinophilia and systemic symptoms].
Annales de pathologieDRESS (drug reaction with eosinophilia and systemic symptoms): a possible prolonged course with sequelae.
European journal of dermatology : EJDDrug reaction with eosinophilia and systemic symptoms with toxic epidermal necrolysis like rash in systemic sclerosis and overlapping sjogren's syndrome: A double trouble triggered by a herbal medicine.
Indian journal of dermatology, venereology and leprologyAdult-Onset Still's Disease With Normal Ferritin Levels and Severe Sulfasalazine-Induced Probable Case of Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome: A Unique Presentation and Management Challenges.
CureusDrug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome Associated With Celecoxib: A Case Report of a Rare Entity.
CureusDrug Reaction With Eosinophilia and Systemic Symptoms to Vancomycin-Laden Cement Space: A Case Report.
CureusGuidelines for the management of drug-induced hypersensitivity syndrome 2023.
The Journal of dermatologyMorbilliform Eruptions: Differentiating Low-Risk Drug Eruptions, Severe Cutaneous Adverse Reactions, Viral Eruptions, and Acute Graft-Versus-Host Disease.
American journal of clinical dermatologyDrug-Induced Hypersensitivity Syndrome/Drug Reaction With Eosinophilia and Systemic Symptoms With Reactivation of Human Herpesvirus-6 in a Liver Transplant Recipient.
Transplant infectious disease : an official journal of the Transplantation SocietyLeflunomide-induced drug reaction eosinophilia systemic symptoms and haemophagocytic lymphohistiocytosis overlap syndrome with rheumatoid arthritis.
BMJ case reportsDRESS Is Not a Rare Complication during the Initial Treatment of Newly Diagnosed Multiple Myeloma: The Experience of Two Medical Institutes.
Acta haematologicaOverlapping of DRESS and Stevens-Johnson syndrome due to first-line antituberculosis drugs: a case report.
Therapeutic advances in drug safetyDrug reaction with eosinophilia and systemic symptoms (DRESS) associated with the use of antiseizure medications-An overview of clinical data.
SeizureOutcomes of ciclosporin treatment in paediatric patients with drug reaction with eosinophilia and systemic symptoms (DRESS): a retrospective cohort analysis.
Clinical and experimental dermatologyA Rare Case of Fatal Toxic Epidermal Necrolysis (TEN) and Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome in a Patient with Rheumatoid Arthritis.
Current drug safetyPharmacogenomics predictors of aromatic antiepileptic drugs-induced SCARs in the Iraqi patients.
HeliyonAn extremely prolonged case of drug reaction with eosinophilia and systemic symptoms (DRESS Syndrome) secondary to a penicillin-based antibiotic.
Anais brasileiros de dermatologiaPost-marketing safety of antiseizure medications: Focus on serious adverse effects including drug reaction with eosinophilia and systemic symptoms (DRESS).
SeizureDRESS Mimicking Flushing Syndrome Associated with Vancomycin: A Case Report.
Current drug safetyDRESSed for distress: a case of allopurinol-induced DRESS syndrome.
Folia medicaPatch Test-Positive Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome Due to Cycloserine in Multidrug-Resistant Tuberculosis: A Case Report with a Review of the Literature.
The American journal of tropical medicine and hygieneAssociações
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Correction: The Hidden Perils of Allopurinol: A Systematic Review of Allopurinol-Induced DRESS (Drug Reaction With Eosinophilia and Systemic Symptoms) Syndrome.
- The Hidden Perils of Allopurinol: A Systematic Review of Allopurinol-Induced DRESS (Drug Reaction With Eosinophilia and Systemic Symptoms) Syndrome.
- A case of steroid-induced mania following lamotrigine-induced drug reaction with eosinophilia and systemic symptoms (DRESS): a cautionary tale.
- Tofacitinib Rescue for Refractory Drug-Induced Liver Injury With Severe DRESS: A Prospective Proof-of-Concept Study.Liver international : official journal of the International Association for the Study of the Liver· 2026· PMID 41823050mais citado
- A Diagnostic Pitfall: Carbamazepine-Induced Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome Masquerading As Angiotensin-Converting Enzyme Inhibitor Angioedema.
- Pediatric Severe Cutaneous Adverse Drug Reactions (SCARs) clinical characteristics and comparison of causality assesment tools and severity scoring systems in relation to clinical outcomes from a single center experience.
- Pulmonary infiltrates as part of drug reaction with eosinophilia and systemic symptoms syndrome in a patient with pulmonary tuberculosis: a clinical conundrum.
- Pembrolizumab and Nivolumab-Induced Late Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS): A Case Report.
- Antiepileptic Drug-Induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): A Case Series.
- Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome Following Carbamazepine Use in a Young Male With Psychiatric Comorbidities.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:139402(Orphanet)
- MONDO:0015340(MONDO)
- GARD:13629(GARD (NIH))
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
- Q3931183(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
