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Síndrome de Harlequin
ORPHA:199282CID-10 · G90.8CID-11 · EE01.0DOENÇA RARA

A Síndrome de Harlequin (HSD) é uma condição que afeta o sistema nervoso autônomo (aquele que controla funções automáticas do corpo) e pode surgir em qualquer idade. Ela se caracteriza por vermelhidão e suor em apenas um lado do rosto (e, às vezes, do braço e do peito), que são desencadeados por calor, exercícios físicos ou estresse emocional. No entanto, não há sintomas nos olhos relacionados à parte simpática do sistema nervoso. Porém, em casos raros, a síndrome pode causar pupilas que reagem de forma anormal, uma lesão nos nervos que controlam os movimentos dos olhos e as pupilas (ligados ao sistema parassimpático) e uma falha do sistema nervoso simpático na capacidade de produzir suor.

Mantido por Agente Raras·Colaborar como especialista →

Introdução

O que você precisa saber de cara

📋

A Síndrome de Harlequin (HSD) é uma condição que afeta o sistema nervoso autônomo (aquele que controla funções automáticas do corpo) e pode surgir em qualquer idade. Ela se caracteriza por vermelhidão e suor em apenas um lado do rosto (e, às vezes, do braço e do peito), que são desencadeados por calor, exercícios físicos ou estresse emocional. No entanto, não há sintomas nos olhos relacionados à parte simpática do sistema nervoso. Porém, em casos raros, a síndrome pode causar pupilas que reagem de forma anormal, uma lesão nos nervos que controlam os movimentos dos olhos e as pupilas (ligados ao sistema parassimpático) e uma falha do sistema nervoso simpático na capacidade de produzir suor.

Publicações científicas
193 artigos
Último publicado: 2026 Apr 8

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
<1 / 1 000 000
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Worldwide
Casos conhecidos
100
pacientes catalogados
Início
All ages
🏥
SUS: Cobertura mínimaScore: 15%
CID-10: G90.8
🇧🇷Dados SUS / DATASUS
PROCEDIMENTOS SIGTAP (2)
0202010694
Sequenciamento completo do exoma (WES)genetic_test
0301070040
Atendimento em reabilitação — doenças rarasrehabilitation
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Entender a doença

Do básico ao detalhe, leia no seu ritmo

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Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🧠
Neurológico
1 sintomas
👁️
Olhos
1 sintomas

+ 10 sintomas em outras categorias

Características mais comuns

55%prev.
Rubor
Frequente (79-30%)
55%prev.
Frieza
Frequente (79-30%)
55%prev.
Anidrose
Frequente (79-30%)
55%prev.
Palidez
Frequente (79-30%)
55%prev.
Síndrome de Horner
Frequente (79-30%)
17%prev.
Cefaleia em salvas
Ocasional (29-5%)
12sintomas
Frequente (5)
Ocasional (5)
Muito raro (2)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 12 características clínicas mais associadas, ordenadas por frequência.

RuborFlushing
Frequente (79-30%)55%
FriezaColdness
Frequente (79-30%)55%
AnidroseAnhidrosis
Frequente (79-30%)55%
PalidezPallor
Frequente (79-30%)55%
Síndrome de HornerHorner syndrome
Frequente (79-30%)55%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico193PubMed
Últimos 10 anos145publicações
Pico202518 papers
Linha do tempo
2026Hoje · 2026🧪 2022Primeiro ensaio clínico📈 2025Ano de pico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Síndrome de Harlequin

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

Pesquisa e ensaios clínicos

Nenhum ensaio clínico registrado para esta condição.

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Publicações mais relevantes

Timeline de publicações
133 papers (10 anos)
#1

Laser therapy: palliative care for the Harlequin syndrome?

Einstein (Sao Paulo, Brazil)2026

Harlequin syndrome is a rare condition characterized by facial dysautonomia with anhidrosis, hemifacial blush, and other nonfacial manifestations without conventional treatment. This report presents a case study of the potential treatment of Harlequin syndrome using laser therapy. A single-case AB design was used, allowing for a systematic comparison between the baseline and intervention phases. The baseline phase involved data collection during a period without intervention (control condition), that is before laser therap. As evaluation criteria, a clinical assessment of skin turgor, sweating or anhidrosis, and blushing was conducted. Additionally, photographic records were taken before and after treatment, and the patient satisfaction index was analyzed. The Treatment Satisfaction Questionnaire for Medication was used as a model, with adaptations made for specific patient cases. The intervention phase included laser therapy. The patient was an 18-year old female diagnosed with Harlequin syndrome without associated comorbidities. The patient was instructed not to undergo any treatment other than the laser therapy. After the laser therapy, the patient reported improvement in symptoms and satisfaction with the outcome and the therapy. It was concluded that, despite being a rare syndrome with limited available information, laser therapy is a viable and efficient approach for treating Harlequin syndrome.

#2

A 17-year-old boy with hemifacial flushing and anhidrosis.

JAAD case reports2026 Apr
#3

Case report of a cardiac Harlequin syndrome-electrical storm during venoarterial extracorporeal membrane oxygenation.

European heart journal. Case reports2025 Feb

In sepsis-induced cardiogenic shock, venoarterial extracorporeal membrane oxygenation (VA-ECMO) can improve survival. Simultaneous acute respiratory distress syndrome (ARDS) increases the risk of differential hypoxia (Harlequin syndrome). Due to desaturated blood ejected by the heart, the head becomes blue, whereas the lower body remains oxygenated by VA-ECMO. We report on an unusual cardiac manifestation, leading to electrical storm. We present the clinical case of a 55-year-old man. During a minor viral pneumonia, superinfection led to severe ARDS and sepsis-induced refractory cardiogenic shock. Venoarterial extracorporeal membrane oxygenation support was initiated. In progressive respiratory failure, an electrocardiogram (ECG) revealed the onset of ST-segment elevations mirroring hypoxic coronary perfusion. As the mixing zone of blood from the heart and the VA-ECMO was in the ascending aorta, hypoxia was limited to the heart. Ventricular arrhythmias recurred, until ventricular fibrillation remained refractory to defibrillation. A second return cannula was inserted into the jugular vein, and veno-arteriovenous ECMO (V-AV-ECMO) was established. After the venous return was added to the circuit, ventricular fibrillation was defibrillated and sinus rhythm remained stable. Within an hour, ST-elevations receded. Systolic function recovered to normal within 26 days. In severe sepsis-related cardiogenic shock, cardiac output is likely to recover. Venoarterial extracorporeal membrane oxygenation is a potential bridge to recovery. Apart from textbook knowledge, Harlequin syndrome can exclusively cause coronary ischaemia, leading to ST-segment elevations and electrical storm. ECGs reveal ST-elevations for early detection. Isolated cardiac Harlequin syndrome can be overlooked or misinterpreted as result of coronary artery disease, but needs immediate therapy to save the patient's life (e.g. V-AV-ECMO).

#4

Harlequin syndrome as part of cervicothoracic spine injury following a fall.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025 Oct
#5

Routine Screening for Neuroblastoma in Harlequin Syndrome Without Otherwise Known Etiology.

Pediatric blood &amp; cancer2025 Mar

Publicações recentes

Ver todas no PubMed

📚 EuropePMC163 artigos no totalmostrando 138

2026

A 17-year-old boy with hemifacial flushing and anhidrosis.

JAAD case reports
2025

A pediatric case of idiopathic harlequin syndrome.

Dermatology online journal
2026

Laser therapy: palliative care for the Harlequin syndrome?

Einstein (Sao Paulo, Brazil)
2025

Post-marketing safety assessment of epinephrine: an analysis of the US FDA adverse event reporting system.

Frontiers in medicine
2025

Idiopathic Harlequin Syndrome: A Case Report of an Uncommon Disease.

Cureus
2025

Harlequin syndrome following paravertebral block adjacent to a stretched pleura: a case report.

BMC anesthesiology
2025

Left robotic assisted thoracic surgery (RATS) stellate ganglion ganglioneuroma resection with post-operative Harlequin syndrome.

Multimedia manual of cardiothoracic surgery : MMCTS
2025

Harlequin Syndrome in Venoarterial ECMO and ECPELLA: When ECMO and Native or Impella Circulations Collide - A Comprehensive Review.

Reviews in cardiovascular medicine
2025

Facial Flushing (Harlequin Syndrome) Following Radiofrequency Ablation Of The Trigeminal Ganglion: A Case Report.

Pain medicine case reports
2025

Unmasking the Harlequin syndrome: A clinical transformation.

JAAD case reports
2025

Harlequin syndrome as part of cervicothoracic spine injury following a fall.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2025

Harlequin syndrome: using clinical features and autonomic testing to unmask the disorder.

Clinical autonomic research : official journal of the Clinical Autonomic Research Society
2025

Harlequin Syndrome in a Post-COVID-19 Infection Elderly: A Case Report.

Acta neurologica Taiwanica
2025

Harlequin Syndrome Caused by Multinodular Goitre.

Cureus
2025

Differential Venous Drainage Mimicking Differential Oxygenation in Patients on Extracorporeal Life Support.

ASAIO journal (American Society for Artificial Internal Organs : 1992)
2025

Delayed Presentation of Horner's and Harlequin-Like Symptoms Following Interscalene Peripheral Nerve Catheter Placement.

Cureus
2025

Harlequin syndrome in a young patient with osteosarcoma after pleural metastasectomy: A case report and a mini review of the literature.

Experimental and therapeutic medicine
2025

Case report of a cardiac Harlequin syndrome-electrical storm during venoarterial extracorporeal membrane oxygenation.

European heart journal. Case reports
2025

Routine Screening for Neuroblastoma in Harlequin Syndrome Without Otherwise Known Etiology.

Pediatric blood &amp; cancer
2024

Algorithm of High-Risk Massive Pulmonary Thromboembolism with Extracorporeal Membrane Oxygenation.

Journal of clinical medicine
2025

Congenital Insensitivity to Pain With Anhidrosis Is Associated With Harlequin Color Change: A Survey Study.

Pediatric dermatology
2024

Images in Vascular Medicine: Analysis of skin microvascular dysfunction in Harlequin syndrome using laser speckle contrast imaging.

Vascular medicine (London, England)
2024

Harlequin sign due to an upper thoracic paravertebral lesion. A systematic review of the literature.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
2024

Harlequin Syndrome: A Rare Association With Migraine.

Neurology
2024

Harlequin syndrome in a patient with probable hemicrania continua and exertional headache - is there a link? a case report.

BMC neurology
2024

What can a thermal imaging camera tell you? Idiopathic Harlequin Syndrome.

Neurologia i neurochirurgia polska
2024

Idiopathic Harlequin Syndrome.

Neurology India
2024

Recognition of a patient with neck autonomic dysfunction: findings from a rare case report of harlequin syndrome in direct access physiotherapy.

The Journal of manual &amp; manipulative therapy
2024

Blood flow and emboli transport patterns during venoarterial extracorporeal membrane oxygenation: A computational fluid dynamics study.

Computers in biology and medicine
2024

Harlequin syndrome: a picture speaks a thousand words.

Medicina intensiva
2024

Brain death determination in patients with veno-arterial extracorporeal membrane oxygenation: A systematic study to address the Harlequin syndrome.

Journal of critical care
2024

To identify Harlequin syndrome in patients with venoarterial extracorporeal membrane oxygenation using radial near-infrared spectroscopy.

Critical care (London, England)
2024

Crossed sympathetic pathways in 3 cases of Harlequin syndrome.

Revue neurologique
2023

Harlequin Syndrome and Autonomic Seizures - A Rare Association.

Annals of Indian Academy of Neurology
2023

Harlequin syndrome in children: secondary until proven otherwise.

BMJ case reports
2023

Veno-Arterial Extracorporeal Membrane Oxygenation for Cardiogenic Shock.

Journal of visualized experiments : JoVE
2023

Sarcoidosis-Associated Sensory Ganglionopathy and Harlequin Syndrome: A Case Report.

Medicina (Kaunas, Lithuania)
2023

"Partial" Harlequin Syndrome in Central Veno-Arterial Extracorporeal Membrane Oxygenation.

Journal of cardiothoracic and vascular anesthesia
2023

Idiopathic Harlequin Syndrome in a Patient from Ethiopia: A Case Report.

Ethiopian journal of health sciences
2023

Extracorporeal Membrane Oxygenation.

Respiratory care
2023

Harlequin syndrome during peripheral cardiopulmonary bypass in a patient with an obstructing tracheal schwannoma: A case report.

Clinical case reports
2024

Successful management of harlequin syndrome due to pulmonary hemorrhage and atelectasis with VAV- ECMO.

Perfusion
2024

Pediatric COVID-19 extracorporeal membrane oxygenation transport during the pandemic.

Perfusion
2023

Harlequin Syndrome Related to Perioperative Intercostal Blockade: A Case Report.

A&amp;A practice
2023

Management of harlequin syndrome under ECPELLA support: A report of two cases and a proposed approach.

Annals of cardiac anaesthesia
2023

Video-assisted thoracoscopic sympathectomy for Harlequin syndrome.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
2023

The effect of arterial cannula tip position on differential hypoxemia during venoarterial extracorporeal membrane oxygenation.

Physical and engineering sciences in medicine
2022

Harlequin syndrome as a complication of epidural anaesthesia in an infant: Do adjunct medications play a role?

Indian journal of anaesthesia
2022

Harlequin Syndrome Following Regional Liposomal Bupivacaine Use in a Partial Sternectomy.

Cureus
2022

Hypothermic Cardiac Arrest Managed Successfully by Changing ECMO Configurations.

Journal of cardiothoracic and vascular anesthesia
2022

Harlequin syndrome induced by intraspinal analgesia in patients with advanced cancer: a case report.

Translational cancer research
2022

Mini-Review on the Harlequin Syndrome-A Rare Dysautonomic Manifestation Requiring Attention.

Medicina (Kaunas, Lithuania)
2022

A novel SCN9A gene variant identified in a Chinese girl with paroxysmal extreme pain disorder (PEPD): a rare case report.

BMC medical genomics
2022

Harlequin Syndrome: Discovery of an Ancient Schwannoma.

Cutis
2022

Hidden Harlequin syndrome in neonatal and pediatric VA-ECMO.

Critical care (London, England)
2022

Harlequin syndrome: An asymmetric face.

Clinical case reports
2022

Harlequin syndrome associated with thoracic epidural anaesthesia.

Anaesthesia reports
2022

SCN10A variants associated with congenital harlequin syndrome.

The British journal of dermatology
2022

Harlequin Syndrome, Apnea, and Acute on Chronic Hemiparesis: An Atypical Pediatric Case of Chiari I With Holocord Syringohydromyelia.

Pediatric neurology
2021

Successful treatment of idiopathic Harlequin Syndrome with oxybutynin and propranolol.

The Australasian journal of dermatology
2021

Harlequin syndrome after surgery for aortic dissection.

Intensive care medicine
2021

Case Report: Left Ventricular Unloading Using a Mechanical CPR Device in a Prolonged Accidental Hypothermic Cardiac Arrest Treated by VA-ECMO - a Novel Approach.

Frontiers in cardiovascular medicine
2021

Harlequin syndrome in a young girl: An opportunity to rethink the terminology.

Pediatric dermatology
2022

Managing Harlequin Syndrome in VA-ECMO - do not forget the right ventricle.

Perfusion
2021

Harlequin syndrome with petechiae caused by a pituitary adenoma.

Journal of the European Academy of Dermatology and Venereology : JEADV
2021

Harlequin syndrome in a pediatric population: a case series.

Acta neurologica Belgica
2021

Must be sympathetic nervous system with unilateral facial flushing in harlequin syndrome.

Lancet (London, England)
2021

Peripheral Cardiopulmonary Bypass in Two Patients With Symptomatic Tracheal Masses: Perioperative Challenges.

Journal of cardiothoracic and vascular anesthesia
2021

Harlequin syndrome associated with ganglioneuroblastoma-induced Horner syndrome.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
2021

Bilateral harlequin syndrome, unilateral Horner syndrome, and Riga-Fede disease as presenting features of hereditary sensory and autonomic neuropathy type IV.

Pediatric dermatology
2020

Harlequin syndrome following microwave ablation in a child with a symptomatic paraspinal mass.

BMJ case reports
2020

Risk of harlequin syndrome during bi-femoral peripheral VA-ECMO: should we pay more attention to the watershed or try to change the venous cannulation site?

Critical care (London, England)
2020

Patient with Cluster Headache and Harlequin Sign - Related or Not?

Headache
2020

Paroxysmal extreme pain disorder in family with c.3892G > T (p.Val1298Phe) in the SCN9A gene mutation - case report.

BMC neurology
2020

A novel veno-arteriovenous extracorporeal membrane oxygenation with double pump for the treatment of Harlequin syndrome.

Perfusion
2020

Detection of subclinical Harlequin syndrome in pediatric patients.

Paediatric anaesthesia
2020

Hemifacial erythema and sweating after exercise in a child.

Pediatric dermatology
2020

Harlequin Color Change in a Neonate.

The New England journal of medicine
2020

Harlequin syndrome caused by isolated focal parasympathetic neuropathy.

Clinical autonomic research : official journal of the Clinical Autonomic Research Society
2020

Harlequin sign in Pancoast tumor.

Current problems in cancer
2019

[Harlequin syndrome after scoliosis surgery].

Der Orthopade
2020

North-south syndrome in veno-arterial extra-corporeal membrane oxygenator: the other Harlequin syndrome.

Canadian journal of anaesthesia = Journal canadien d'anesthesie
2019

Harlequin Syndrome after Thoracoscopic Repair of a Child with Tracheoesophageal Fistula (TEF).

European journal of pediatric surgery reports
2019

Idiopathic harlequin syndrome: a case report and literature review.

The Pan African medical journal
2019

Cardiac Sympathetic Hyperactivity of Lung Cancer-Associated Harlequin Syndrome.

JMA journal
2019

Pure autonomic failure presenting as Harlequin syndrome.

Autonomic neuroscience : basic &amp; clinical
2019

Harlequin Syndrome in Acute Thalamic Hemorrhage.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
2019

Image Gallery: A case of Harlequin and Horner syndromes.

The British journal of dermatology
2019

Harlequin Syndrome during Venoarterial Extracorporeal Membrane Oxygenation.

Radiology. Cardiothoracic imaging
2019

Cross-Field Ventilation for Treatment of Harlequin Syndrome in Traumatic Tracheobronchial Injury Repair Using Intraoperative Venoarterial Extracorporeal Membrane Oxygenation.

Journal of cardiothoracic and vascular anesthesia
2019

Harlequin Syndrome Associated with Erector Spinae Plane Block.

Anesthesiology
2019

Neurologic aspects of sweating and its disorders.

Neurology
2019

Branch Retinal Vein Occlusion in Ipsilateral Harlequin Syndrome.

Klinische Monatsblatter fur Augenheilkunde
2019

Unilateral Anhidrosis With Ipsilateral Basal Cell Carcinomas.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
2019

Unconventional Cannulation Strategy in Peripheral Extracorporeal Membrane Oxygenation to Achieve Central Perfusion and Prevent Differential Hypoxia.

Journal of cardiothoracic and vascular anesthesia
2018

Child Neurology: An infant with episodic facial flushing: A rare case and review of congenital harlequin syndrome.

Neurology
2018

Do you know this syndrome? Harlequin syndrome.

Anais brasileiros de dermatologia
2019

[Harlequin syndrome secondary to a neuroblastoma].

Anales de pediatria
2018

Position of draining venous cannula in extracorporeal membrane oxygenation for respiratory and respiratory/circulatory support in adult patients.

Critical care (London, England)
2018

Postoperative Harlequin Syndrome: Case Report of a Rare but Clinically Striking Condition.

A&amp;A practice
2018

[Harlequin syndrome: Two sides of the same disease].

Semergen
2018

Harlequin syndrome following upper lobectomy.

Asian cardiovascular &amp; thoracic annals
2018

Isolated Harlequin Syndrome Following Brachial Plexus Nerve Block via Interscalene Approach: A Case Report.

AANA journal
2018

Harlequin syndrome as a rare complication after epidural anesthesia in an obstetric patient.

Minerva anestesiologica
2018

Controlled flow diversion in hybrid venoarterial-venous extracorporeal membrane oxygenation.

Interactive cardiovascular and thoracic surgery
2017

Harlequin syndrome and Horner syndrome after neck schwannoma excision in a pediatric patient: A case report.

Medicine
2017

Development of Harlequin Syndrome following placement of thoracic epidural anesthesia in a pediatric patient undergoing Nuss procedure.

Clinical case reports
2017

Unilateral facial and upper truncal anhidrosis and absence of physiological flushing: A case of idiopathic harlequin syndrome.

Indian journal of dermatology, venereology and leprology
2017

Three Extremely Rare Findings in the Same Patient: Harlequin Syndrome, Thyrocervical Trunk Aneurysm, and Systemic-Pulmonary Arterio-Arterial Fistula.

Annals of vascular surgery
2017

Harlequin Syndrome Following Resection of Mediastinal Ganglioneuroma.

The Korean journal of thoracic and cardiovascular surgery
2017

Idiopathic Harlequin Syndrome Manifesting during Exercise: A Case Report and Review of the Literature.

Case reports in medicine
2017

Harlequin sign concomitant with Horner syndrome after anterior cervical discectomy: a case of intrusion into the cervical sympathetic system.

Journal of neurosurgery. Spine
2017

Congenital Cases of Concomitant Harlequin and Horner Syndromes.

The Journal of pediatrics
2016

Harlequin Syndrome Associated with Multilevel Intercostal Nerve Block.

Anesthesiology
2016

Harlequin syndrome with contralateral anhidrosis after an upper chest gunshot wound.

BMJ case reports
2016

Harlequin Syndrome after Stellate Ganglia Neuroblastoma Resection.

The Journal of pediatrics
2018

Harlequin syndrome in a paediatric patient: A diagnostic challenge.

Neurologia
2016

Harlequin Syndrome in Cluster Headache.

Headache
2017

Venous Cannula Positioning in Arterial Deoxygenation During Veno-Arterial Extracorporeal Membrane Oxygenation-A Simulation Study and Case Report.

Artificial organs
2016

A Case of Undiagnosed Harlequin Syndrome Presenting in General Dental Practice.

Dental update
2016

[Harlequin phenomenon associated with neurological abnormalities: A case report].

Annales de dermatologie et de venereologie
2016

[Harlequin syndrome in a melanoderm patient].

Revue de stomatologie, de chirurgie maxillo-faciale et de chirurgie orale
2016

Congenital Harlequin syndrome as an isolated phenomenon: A case report and review of the literature.

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
2015

Harlequin color change in preterm infant.

The Pan African medical journal
2015

Pitfalls in percutaneous ECMO cannulation.

Heart, lung and vessels
2016

Botulinum toxin for treatment of Harlequin syndrome.

Parkinsonism &amp; related disorders
2016

Harlequin syndrome in a patient with putative autoimmune autonomic ganglionopathy.

Autonomic neuroscience : basic &amp; clinical
2015

Unusual pattern of neonatal hyperhidrosis.

BMJ case reports
2016

Harlequin Syndrome After Thoracic Paravertebral Block.

A &amp; A case reports
2015

Harlequin Syndrome Following Implantation of Intrathecal Pumps: A Case Series.

Neuromodulation : journal of the International Neuromodulation Society
2015

Harlequin Syndrome Associated with Thoracic Epidural Analgesia.

Anesthesiology
2015

Harlequin syndrome: a mask of rare dysautonomic syndromes.

Dermatology online journal
2015

[A woman with unilateral flushing of her face].

Nederlands tijdschrift voor geneeskunde
2016

Horner's, Heterochromia, and Harlequins.

Journal of general internal medicine
2015

Iatrogenic harlequin syndrome: a new case.

Annals of dermatology
2014

[Evaluation of sudomotor function].

Rinsho shinkeigaku = Clinical neurology
2015

Concurrent Horner's and Harlequin syndromes.

International journal of oral and maxillofacial surgery
2015

Hemifacial Erythema in Right Unilateral Electroconvulsive Therapy.

The journal of ECT
Ver todos os 163 no EuropePMC

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Doenças relacionadas

Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico

Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Laser therapy: palliative care for the Harlequin syndrome?
    Einstein (Sao Paulo, Brazil)· 2026· PMID 41711785mais citado
  2. A 17-year-old boy with hemifacial flushing and anhidrosis.
    JAAD case reports· 2026· PMID 41859431mais citado
  3. Case report of a cardiac Harlequin syndrome-electrical storm during venoarterial extracorporeal membrane oxygenation.
    European heart journal. Case reports· 2025· PMID 39974845mais citado
  4. Harlequin syndrome as part of cervicothoracic spine injury following a fall.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology· 2025· PMID 40751882mais citado
  5. Routine Screening for Neuroblastoma in Harlequin Syndrome Without Otherwise Known Etiology.
    Pediatric blood &amp; cancer· 2025· PMID 39777961mais citado
  6. Harlequin Syndrome with Ipsilateral Facial Flushing After Internal Carotid Artery Dissection: An Atypical Sympathetic Laterality Pattern.
    Clin Exp Emerg Med· 2026· PMID 41952484recente
  7. Harlequin syndrome: segmental autonomic dysfunction in the realm of Sjogren's disease.
    Rheumatology (Oxford)· 2026· PMID 41904663recente
  8. A pediatric case of idiopathic harlequin syndrome.
    Dermatol Online J· 2025· PMID 41725483recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:199282(Orphanet)
  2. MONDO:0016040(MONDO)
  3. GARD:8610(GARD (NIH))
  4. Busca completa no PubMed(PubMed)
  5. Q5658687(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Síndrome de Harlequin
Compêndio · Raras BR

Síndrome de Harlequin

ORPHA:199282 · MONDO:0016040
Prevalência
<1 / 1 000 000
Casos
100 casos conhecidos
Herança
Not applicable
CID-10
G90.8 · Outros transtornos do sistema nervoso autônomo
CID-11
Início
All ages
Prevalência
0.0 (Worldwide)
MedGen
UMLS
C2029348
EuropePMC
Wikidata
Papers 10a
DiscussaoAtiva

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