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Hemicrania paroxística
ORPHA:157835CID-10 · G44.0CID-11 · 8A82DOENÇA RARA

A hemicrania paroxística (HP) é uma cefaleia primária caracterizada por múltiplos ataques de dor unilateral que ocorrem em associação com sintomas autonômicos cranianos. As características desta síndrome são a relativa brevidade dos ataques e a resposta completa à terapia com indometacina.

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Introdução

O que você precisa saber de cara

📋

A hemicrania paroxística (HP) é uma cefaleia primária caracterizada por múltiplos ataques de dor unilateral que ocorrem em associação com sintomas autonômicos cranianos. As características desta síndrome são a relativa brevidade dos ataques e a resposta completa à terapia com indometacina.

Pesquisas ativas
3 ensaios
3 total registrados no ClinicalTrials.gov
Publicações científicas
465 artigos
Último publicado: 2026 Apr

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
Unknown
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Europe
Início
Adolescent
+ adult, childhood, elderly
🏥
SUS: Cobertura mínimaScore: 20%
Triagem neonatal (Fase 5)CID-10: G44.0
🇧🇷Dados SUS / DATASUS
PROCEDIMENTOS SIGTAP (2)
0202010694
Sequenciamento completo do exoma (WES)genetic_test
0301070040
Atendimento em reabilitação — doenças rarasrehabilitation
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Entender a doença

Do básico ao detalhe, leia no seu ritmo

Preparando trilha educativa...

Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

👁️
Olhos
3 sintomas
🫃
Digestivo
1 sintomas
📏
Crescimento
1 sintomas

+ 16 sintomas em outras categorias

Características mais comuns

90%prev.
Enxaqueca
Muito frequente (99-80%)
90%prev.
Cefaleia paroxística recorrente
Muito frequente (99-80%)
55%prev.
Epífora
Frequente (79-30%)
55%prev.
Rinite
Frequente (79-30%)
55%prev.
Rubor
Frequente (79-30%)
55%prev.
Rinorreia
Frequente (79-30%)
21sintomas
Muito frequente (2)
Frequente (8)
Ocasional (9)
Muito raro (2)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 21 características clínicas mais associadas, ordenadas por frequência.

EnxaquecaMigraine
Muito frequente (99-80%)90%
Cefaleia paroxística recorrenteRecurrent paroxysmal headache
Muito frequente (99-80%)90%
EpíforaEpiphora
Frequente (79-30%)55%
RiniteRhinitis
Frequente (79-30%)55%
RuborFlushing
Frequente (79-30%)55%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico465PubMed
Últimos 10 anos116publicações
Pico201716 papers
Linha do tempo
2026Hoje · 2026🧪 2016Primeiro ensaio clínico📈 2017Ano de pico
Publicações por ano (últimos 10 anos)

Triagem neonatal (Teste do Pezinho)

👶
Teste: qPCR para deleção de SMN1 em sangue seco
Fase 5 do PNTNpending
Incidência no Brasil: 1:10.000

A triagem neonatal permite diagnóstico precoce e início imediato do tratamento.

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Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
2Fase 21
1Fase 11
·Pré-clínico1
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 3 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Hemicrania paroxística

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

🟢 Recrutando agora

3 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

Outros ensaios clínicos

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Publicações mais relevantes

Timeline de publicações
111 papers (10 anos)
#1

Bridging the gap: molecular mechanisms, regional activity and connectivity in headache disorders.

Brain : a journal of neurology2026 Mar 05

Chronic headache disorders have a tremendous impact on psychosocial functioning. Despite the availability of various treatment options, suboptimal management remains present in a subset of patients, leading to persistent suffering. Molecular mechanisms, regional activity patterns and connectivity pathways are crucial for understanding the pathophysiology, serving as a foundation for developing novel treatments, refining existing therapies, and ultimately optimizing the management of headache disorders. Nevertheless, articles combining fundamental and clinical aspects of the pathophysiology and treatment of headache disorders remain limited. The current literature review provides a thorough overview of the molecular mechanisms, regional activity patterns and connectivity pathways involved in migraine, cluster headache (CH), paroxysmal hemicrania (PH), hemicrania continua (HC) and occipital neuralgia (ON), thereby bridging the gap between different fields of expertise. In this scoping review, literature on molecular mechanisms, regional activity and connectivity pathways for migraine, CH, PH, HC and ON has been collected from the PubMed, MEDLINE and EMBASE databases. Reports were also manually searched using the search function in Google Scholar, as well as reviews or references cited within the articles. In total, 130 and 97 articles, published between 1976 and 2024, are included in the analysis of the molecular mechanism and regional activity patterns/connectivity pathways, respectively. Molecular data show that the trigeminal nucleus caudalis is a central structure in headache pathology, comprising various neuropeptides and neurochemicals, including vasoactive intestinal peptide, glutamate, substance P and serotonin, and connecting the pathophysiology of these headache disorders. Sensitization of higher cortical brain areas, neuroinflammation within the trigeminal system and vasodilatation of cranial vessels seem to contribute to headache pain. Headache disorders are also associated with atypical regional activity patterns and connectivity pathways in pain processing areas, as well as the default mode network, salience network, and sensorimotor network. These abnormalities help explain the mechanisms underlying overall headache-related symptoms and additional manifestations unique to each headache disorder, including cortical spreading depression in migraine, rhythmicity of attacks in CH and autonomic symptoms in CH, PH and HC. The article fosters a deeper understanding of the molecular mechanisms, neuronal pathways and clinical symptoms involved in headache pathology across different fields of expertise. By bridging these perspectives, it provides essential insights for developing innovative treatment strategies and enhancing existing therapeutic options.

#2

Indomethacin-Responsive Headaches in Children and Adolescents: A Pearls and Pitfalls Case Series.

Journal of child neurology2026 Mar

BackgroundHemicrania continua and paroxysmal hemicrania are rare in the pediatric population. Recognizing these disorders characterized by unilateral headaches with autonomic features can reduce time to diagnosis, facilitate effective medical treatment, and reduce morbidity.ObjectiveTo review the diagnostic criteria and pathophysiology of hemicrania continua and paroxysmal hemicrania, analyze a retrospective cohort of adolescent patients with indomethacin-responsive headaches, and discuss the clinical features of these patients, both in how they follow the diagnostic criteria for these disorders and how they may deviate. We also examined time to diagnosis and prognosis for this cohort.MethodsA retrospective chart review was completed of patients 12-18 years old from 2014 to 2021 diagnosed with indomethacin-responsive headaches who presented to a tertiary pediatric headache clinic. Clinical headache characteristics, demographic features, medical diagnoses, and diagnostic testing were reviewed and collated.ResultsEight patients (7 female, 1 male) had indomethacin-responsive headaches. Six patients were diagnosed with hemicrania continua and 2 were diagnosed with paroxysmal hemicrania. The most common autonomic symptoms were unilateral nasal congestion and conjunctival injection/lacrimation. The median time to diagnosis was 15 months, and the median treatment length was 7 months.ConclusionPatients can have multiple headache phenotypes. Clinicians should ask headache patients of all ages about autonomic symptoms and unilateral headaches, specifically in fixed unilateral headaches. These headaches should be evaluated with imaging to rule out secondary intracranial causes. In those cases, with these features, an indomethacin trial is part of the diagnosis and should be considered early in the course.

#3

A rare case of secondary paroxysmal hemicrania caused by a T1 nerve root schwannoma.

Pain reports2026 Apr

Paroxysmal hemicrania (PH) is a rare headache disorder of severe intensity, which is classified within the group of trigeminal autonomic cephalalgias and is renowned for its prompt response to indomethacin. Since its first description in 1974, only few cases of secondary PH have been published and even fewer with distinct lesions and a clear pathophysiological association. We here present a unique case of long-standing secondary PH, which resolved permanently after resection of a schwannoma of the T1 nerve root, which carries sympathetic projections to the periorbital region. The current case stresses the importance of sympathetic/parasympathetic dysregulation in the pathophysiological origination of PH, which is far beyond purely central mechanisms. It is the first case ever published, which shows a quite remote peripheral pathology causing a trigeminal autonomic headache disorder. This case has important implications on a better understanding of the pathophysiology and future diagnostic workup of PH, which should ideally include imaging not only of the brain but also of the spine down to the thoracic level.

#4

Prevalence, demographics, comorbidities, and treatment patterns of patients with the trigeminal autonomic cephalalgias: a retrospective analysis of United States electronic health records.

BMC neurology2025 Jul 21

The study of the trigeminal autonomic cephalalgias (TAC) has been limited by difficulty aggregating sufficient numbers of patients. We used the Epic Cosmos electronic health record research platform to harness nationwide data from health care systems across the United States using the Epic electronic health record to analyze the prevalence, demographics, comorbid conditions and treatments for the TACs. We queried the Epic Cosmos electronic health record database for patients with diagnoses of hemicrania continua, cluster headache, paroxysmal hemicrania, and SUNCT. Prevalences, demographics were determined from this database and comorbid conditions and treatments for these conditions were analyzed. Our study included 152,727 patients with cluster headache, 59,312 patients with paroxysmal hemicrania, 19,321 patients with hemicrania continua, and 6,291 patients with SUNCT. Five-year prevalence of cluster headache was highest (56.7 per 100,000), followed by paroxysmal hemicrania (22.0 per 100,000), hemicrania continua (7.2 per 100,000) and SUNCT (2.3 per 100,000). All four TACs showed a higher prevalence in women. Migraine was common in all four conditions and patients with cluster headache had the highest rates of nicotine, alcohol, and cannabis use disorders. Indomethacin was notably underutilized for the indomethacin-responsive TACs. We use a national electronic medical record database to give insight into elements of the TACs that have been previously limited by the relative rarity of these diseases.

#5

How can you manage an indomethacin-responsive headache in someone who cannot take indomethacin?

Current opinion in neurology2025 Jun 01

Paroxysmal hemicrania and hemicrania continua are rare primary headache disorders which are distinguished by an absolute response to indomethacin. As a matter of importance, no guidelines have been proposed for alternative therapeutic options in case of indomethacin intolerance. The purpose of this review is to provide an update on the current findings, especially focusing on the past 18 months, in the treatment of both paroxysmal hemicrania and hemicrania continua and to provide proposed management recommendations based on summarized evidence. Apart from well recognized gastrolesive effects of indomethacin, a substantial number of patients may suffer from neuropsychiatric adverse reactions. Recent studies demonstrated that melatonin, which has been known for its effectiveness for hemicrania continua, is also useful for paroxysmal hemicrania. Promising nonpharmacological treatment option, which is noninvasive vagus nerve stimulation, has been shown to be beneficial for both indomethacin-responsive headache disorders allowing the reduction of indomethacin dosage. Although the data on substitutive medication choice for indomethacin are currently scarce, the most consistent results have been repeatedly achieved with acemethacin, selective COX-2 inhibitors, and anticonvulsants. However, considering the crucial role of pathophysiology, research investigating the efficacy of drugs targeting the trigemino-vascular system activation, as well as controlled trials assessing the efficacy involving the aforementioned therapeutic options are still vague. In spite of numerous reports suggesting reliable alternatives to indomethacin, the consensus on pharmacological therapy guidelines for indomethacin-responsive headache disorders has not yet been reached. Further research and agreement from the experts' standpoint are needed for an establishment of reliable treatment recommendations.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC227 artigos no totalmostrando 113

2026

A rare case of secondary paroxysmal hemicrania caused by a T1 nerve root schwannoma.

Pain reports
2025

From paroxysmal hemicrania to SUNCT: a unique presentation of herpetic zoster ophthalmicus: a case report.

Frontiers in ophthalmology
2025

Paroxysmal hemicrania: A diagnostic challenge presenting as orofacial pain: A case series.

Cranio : the journal of craniomandibular practice
2025

A Comprehensive Review of Trigeminal Autonomic Cephalalgias.

Physical medicine and rehabilitation clinics of North America
2025

Direct cost of headache treatment in Benin, a West African country, in 2023.

The journal of headache and pain
2026

Bridging the gap: molecular mechanisms, regional activity and connectivity in headache disorders.

Brain : a journal of neurology
2025

Neuromodulation in trigeminal autonomic cephalalgias: 11-year experience of non-invasive vagus nerve stimulation.

Cephalalgia : an international journal of headache
2025

Paroxysmal hemicrania-like headache secondary to an ischemic stroke.

Headache
2026

Indomethacin-Responsive Headaches in Children and Adolescents: A Pearls and Pitfalls Case Series.

Journal of child neurology
2025

Prevalence, demographics, comorbidities, and treatment patterns of patients with the trigeminal autonomic cephalalgias: a retrospective analysis of United States electronic health records.

BMC neurology
2025

Indomethacin-responsive refractory headache: Two case reports in children after hemispherectomy for Rasmussen's encephalitis.

Headache
2025

Co-morbid Indomethacin-Responsive Headaches in a Woman in Her Late 60s With Paroxysmal Hemicrania and Hypnic Headache: A Case Report.

Cureus
2025

How can you manage an indomethacin-responsive headache in someone who cannot take indomethacin?

Current opinion in neurology
2024

World neurology updates: Other primary headache disorder - Treatment.

eNeurologicalSci
2024

Prophylactic Cyproheptadine to Control Paroxysmal Hemicrania Attacks: A Preliminary Investigation.

Advanced biomedical research
2024

Indomethacin-responsive trigeminal autonomic cephalgias: a review of key characteristics and pathophysiology.

Neurologia i neurochirurgia polska
2024

Indomethacin-Responsive Headache Disorders.

Continuum (Minneapolis, Minn.)
2024

Neurophysiological investigations in a case of primary paroxysmal hemicrania-tic syndrome.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2024

Melatonin in hemicrania continua and paroxysmal hemicrania.

Cephalalgia : an international journal of headache
2024

One-year prevalence of cluster headache, hemicrania continua, paroxysmal hemicrania and SUNCT in Norway: a population-based nationwide registry study.

The journal of headache and pain
2024

SUNCT, SUNA and short-lasting unilateral neuralgiform headache attacks: Debates and an update.

Cephalalgia : an international journal of headache
2024

Complementary and Integrative Medicine for the Treatment of Trigeminal Neuralgia and Trigeminal Autonomic Cephalalgia.

Current pain and headache reports
2023

Hidden in the Rash: A Sneddon Syndrome Case Report.

Cureus
2024

Epidemiology and clinical features of paroxysmal hemicrania: A systematic review and meta-analysis.

Headache
2023

Paroxysmal hemicrania and hemicrania continua: Review on pathophysiology, clinical features and treatment.

Cephalalgia : an international journal of headache
2023

Cigarette smoking history (personal and secondary childhood exposure) in non-cluster headache trigeminal autonomic cephalalgias: A clinic based study.

Cephalalgia : an international journal of headache
2023

Trigeminal Autonomic Cephalalgias and Neuralgias in Children and Adolescents: a Narrative Review.

Current neurology and neuroscience reports
2023

Symptomatic trigeminal autonomic cephalalgias in neuromyelitis optica spectrum disorders.

Multiple sclerosis and related disorders
2023

Long term outcomes of occipital nerve stimulation.

Frontiers in pain research (Lausanne, Switzerland)
2023

Non-invasive neuromodulation of the cervical vagus nerve in rare primary headaches.

Frontiers in pain research (Lausanne, Switzerland)
2023

Management of Trigeminal Autonomic Cephalalgias Including Chronic Cluster: A Review.

JAMA neurology
2022

Recent Advances and Updates in Trigeminal Autonomic Cephalalgias.

Seminars in neurology
2022

Paroxysmal hemicrania in children and adolescents: A systematic review.

Headache
2022

Paroxysmal hemicrania or short-lasting unilateral neuralgiform headache attacks with trigeminal neuralgia - functional neuroimaging findings.

Neurologia i neurochirurgia polska
2022

The spectrum of indomethacin-responsive headaches in children and adolescents.

Cephalalgia : an international journal of headache
2022

[Autonomic Disorders in Trigeminal Autonomic Cephalalgias: An Update].

Brain and nerve = Shinkei kenkyu no shinpo
2021

[Trigeminal autonomic cephalgias: features of diagnosis and treatment].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
2021

A New Treatment Option for Children With Refractory Chronic Paroxysmal Hemicranias: Occipital Nerve Stimulation.

Pediatric neurology
2022

Aura in trigeminal autonomic cephalalgia is probably mediated by comorbid migraine with aura.

Cephalalgia : an international journal of headache
2021

Pediatric-onset trigeminal autonomic cephalalgias: A systematic review and meta-analysis.

Cephalalgia : an international journal of headache
2022

Indomethacin has no effect on trigeminally provoked parasympathetic output.

Cephalalgia : an international journal of headache
2022

A Combination of Indomethacin Farnesyl and Amitriptyline Is Effective for Continuous Interictal Pain with Probable Chronic Paroxysmal Hemicrania.

Internal medicine (Tokyo, Japan)
2021

The Promising Effect of Nerve Decompression in Trigeminal Autonomic Cephalalgias: Report of Case Series.

Frontiers in neurology
2021

Indomethacin-responsive headaches-A narrative review.

Headache
2021

Noninvasive Neuromodulation in Headache: An Update.

Neurology India
2021

Paroxysmal Hemicrania: An Update.

Neurology India
2021

Role of Functional Neuroimaging in Primary Headache Disorders.

Neurology India
2021

Management of cluster headache and other trigeminal autonomic cephalalgias in pregnancy and breastfeeding.

European journal of neurology
2021

Paroxysmal hemifacial pain: A report of two cases.

Headache
2021

Long-Term Outcome of Indomethacin Treatment in Pediatric Patients with Paroxysmal Hemicrania-A Case Series.

Children (Basel, Switzerland)
2020

Carotid body tumor as a potential cause of paroxysmal hemicrania.

Journal of vascular surgery cases and innovative techniques
2020

Paroxysmal hemicrania masquerading as a stroke in an elderly gentleman: case report.

BMC geriatrics
2021

SUNCT/SUNA in children and adolescents: Application of ICHD-3 criteria and treatment response: Case series of 13 SUNCT/SUNA pediatric cases.

Cephalalgia : an international journal of headache
2020

Cluster headache and TACs: state of the art.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2021

Differential actions of indomethacin: clinical relevance in headache.

Pain
2020

[Cluster headache and other trigeminal autonomic cephalalgias].

Nederlands tijdschrift voor geneeskunde
2020

Very young age of onset in trigemino-autonomic cephalalgias - case report and review of the literature.

Cephalalgia : an international journal of headache
2020

Headache Attack Similar to Paroxismal Hemicrania Seen During Flight.

Aerospace medicine and human performance
2020

Headache in the Older Population: Causes, Diagnoses, and Treatments.

Current pain and headache reports
2020

Cerebral Sinus Venous Thrombosis Mimicking Probable Paroxysmal Hemicrania: A Case Report.

Headache
2019

Trigeminal Autonomic Cephalalgias.

Neurologic clinics
2019

Facial presentations of migraine, TACs, and other paroxysmal facial pain syndromes.

Neurology
2019

Are repetitive pericranial nerve blocks effective in the management of chronic paroxysmal hemicrania?: A case report.

Medicine
2019

Presentation and Management of Headache in Pituitary Apoplexy.

Current pain and headache reports
2019

Case Report: Shortest Course of Pediatric Paroxysmal Hemicrania.

Headache
2019

Do paroxysmal hemicrania and hemicrania continua represent different headaches? A retrospective study.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2019

Multiple cranial nerve blocks for the transitional treatment of chronic headaches.

Cephalalgia : an international journal of headache
2019

Non-invasive vagus nerve stimulation is beneficial in chronic paroxysmal hemicrania.

Journal of neurology, neurosurgery, and psychiatry
2019

The Treatment of Trigeminal Autonomic Cephalalgias: An Overview.

Journal of oral &amp; facial pain and headache
2018

Cluster Headache and Other Trigeminal Autonomic Cephalalgias.

Continuum (Minneapolis, Minn.)
2018

Hints on Diagnosing and Treating Headache.

Deutsches Arzteblatt international
2018

Secondary (Symptomatic) Trigeminal Autonomic Cephalalgia.

Annals of Indian Academy of Neurology
2018

Functional Neuroimaging in Trigeminal Autonomic Cephalalgias.

Annals of Indian Academy of Neurology
2018

Classification of Trigeminal Autonomic Cephalalgia: What has Changed in International Classification of Headache Disorders-3 Beta?

Annals of Indian Academy of Neurology
2018

Overview of Trigeminal Autonomic Cephalalgias: Nosologic Evolution, Diagnosis, and Management.

Annals of Indian Academy of Neurology
2018

When Treatment Establishes Diagnosis: A Case Report of Posttraumatic Chronic Paroxysmal Hemicrania.

Headache
2018

Trait- and Frequency-Dependent Dysfunctional Habituation to Trigeminal Nociceptive Stimulation in Trigeminal Autonomic Cephalalgias.

The journal of pain
2018

Therapeutic Approaches for the Management of Trigeminal Autonomic Cephalalgias.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
2017

Indomethacin-Responsive Paroxysmal Hemicrania in an Elderly Man: An Unusual Presentation of Pituitary Apoplexy.

Headache
2017

Occipital Nerve Stimulation for Medically Refractory Chronic Paroxysmal Hemicrania.

Headache
2018

The pathophysiology of the trigeminal autonomic cephalalgias, with clinical implications.

Clinical autonomic research : official journal of the Clinical Autonomic Research Society
2017

Noninvasive Vagus Nerve Stimulation for Treatment of Indomethacin-Sensitive Headaches.

JAMA neurology
2017

Therapeutical approaches to paroxysmal hemicrania, hemicrania continua and short lasting unilateral neuralgiform headache attacks: a critical appraisal.

The journal of headache and pain
2017

LASH: A Review of the Current Literature.

Current pain and headache reports
2017

Tics in TACs: A Step into an Avalanche? Systematic Literature Review and Conclusions.

Headache
2017

Sphenopalatine Ganglion Block in the Management of Chronic Headaches.

Current pain and headache reports
2017

"Cough Hemicrania" - An Overlapping Form of Headache: Case Reports.

Headache
2017

Paroxysmal Hemicrania-Like Headache Secondary to Phosphodiesterase Inhibitors Administration: A Case Report.

Headache
2017

Cracked tooth syndrome mimicking trigeminal autonomic cephalalgia: A report of four cases.

Quintessence international (Berlin, Germany : 1985)
2017

The Rare Painful Phenomena - Chronic Paroxysmal Hemicrania-tic Syndrome as a Clinically Isolated Syndrome of the Central Nervous System.

Pain physician
2015

O043. Frequency-dependent habituation deficit of the nociceptive blink reflex in cluster headache and paroxysmal hemicrania.

The journal of headache and pain
2018

Chronic paroxysmal headache secondary to an orbital metastatic leiomyosarcoma: A case report.

Cephalalgia : an international journal of headache
2017

Management of children and young people with headache.

Archives of disease in childhood. Education and practice edition
2017

Hemicrania Continua-Like Headache Related to Transdermal Nitroglycerine Therapy.

Headache
2016

Side-locked headaches: an algorithm-based approach.

The journal of headache and pain
2017

The anterior hypothalamus in cluster headache.

Cephalalgia : an international journal of headache
2017

Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing-like attacks in a pediatric patient found to have a pontine capillary telangiectasia and developmental venous anomaly: A case report exploring the root of the problem.

Cephalalgia : an international journal of headache
2016

Alcohol-induced headaches: Evidence for a central mechanism?

Journal of neurosciences in rural practice
2016

Trigeminal autonomic cephalalgia as a presenting feature of Neuromyelitis Optica: "A rare combination of two uncommon disorders".

Multiple sclerosis and related disorders
2016

Linear headache: clinical characteristics of eight new cases.

SpringerPlus
2016

Coexistence of contralateral cluster headache and probable paroxysmal hemicrania: a case report.

SpringerPlus
2016

Can paroxysmal hemicrania be bilateral? A case report.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2016

Trigeminal Autonomic Cephalalgias in Children and Adolescents: Cluster Headache and Related Conditions.

Seminars in pediatric neurology
2017

The cavernous sinus in cluster headache - a quantitative structural magnetic resonance imaging study.

Cephalalgia : an international journal of headache
2016

Hemicrania continua may respond to repetitive sphenopalatine ganglion block: A case report.

Headache
2016

Deep brain stimulation in headache.

Cephalalgia : an international journal of headache
2015

The Neuropharmacology of Cluster Headache and other Trigeminal Autonomic Cephalalgias.

Current neuropharmacology
2015

Pediatric paroxysmal hemicrania: a case report and some clinical considerations.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2015

Putative pathophysiological mechanisms in recurrent hemicrania from aortic dissection: a case report.

BMC research notes
2015

Do trigeminal autonomic cephalalgias represent primary diagnoses or points on a continuum?

Current pain and headache reports
2015

Cluster headache and trigeminal autonomic cephalgias.

Disease-a-month : DM
2015

When indomethacin fails: additional treatment options for "indomethacin responsive headaches".

Current pain and headache reports
2015

[Trigeminal autonomic cephalgias].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
Ver todos os 227 no EuropePMC

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Referências e fontes

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Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Bridging the gap: molecular mechanisms, regional activity and connectivity in headache disorders.
    Brain : a journal of neurology· 2026· PMID 40995873mais citado
  2. Indomethacin-Responsive Headaches in Children and Adolescents: A Pearls and Pitfalls Case Series.
    Journal of child neurology· 2026· PMID 40717615mais citado
  3. A rare case of secondary paroxysmal hemicrania caused by a T1 nerve root schwannoma.
    Pain reports· 2026· PMID 41717391mais citado
  4. Prevalence, demographics, comorbidities, and treatment patterns of patients with the trigeminal autonomic cephalalgias: a retrospective analysis of United States electronic health records.
    BMC neurology· 2025· PMID 40691779mais citado
  5. How can you manage an indomethacin-responsive headache in someone who cannot take indomethacin?
    Current opinion in neurology· 2025· PMID 39911098mais citado
  6. Beyond indomethacin: a case report of chronic paroxysmal hemicrania with remarkable response to non-invasive vagus nerve stimulation.
    Neurologia (Engl Ed)· 2026· PMID 41765128recente
  7. From paroxysmal hemicrania to SUNCT: a unique presentation of herpetic zoster ophthalmicus: a case report.
    Front Ophthalmol (Lausanne)· 2025· PMID 41476707recente
  8. Paroxysmal hemicrania: A diagnostic challenge presenting as orofacial pain: A case series.
    Cranio· 2025· PMID 41456204recente
  9. A Comprehensive Review of Trigeminal Autonomic Cephalalgias.
    Phys Med Rehabil Clin N Am· 2025· PMID 41167853recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:157835(Orphanet)
  2. MONDO:0015529(MONDO)
  3. GARD:10794(GARD (NIH))
  4. Busca completa no PubMed(PubMed)
  5. Q42324521(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Hemicrania paroxística
Compêndio · Raras BR

Hemicrania paroxística

ORPHA:157835 · MONDO:0015529
🇧🇷 Brasil SUS
Triagem
qPCR para deleção de SMN1 em sangue seco
PNTN
Fase 5
Incidência BR
1:10.000
Geral
Prevalência
Unknown
Herança
Not applicable
CID-10
G44.0 · Síndrome de "cluster-headache"
CID-11
Ensaios
3 ativos
Início
Adolescent, Adult, Childhood, Elderly
Prevalência
0.0 (Europe)
MedGen
UMLS
C0393743
EuropePMC
Wikidata
Papers 10a
DiscussaoAtiva

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