Doença linfoproliferativa associada a vírus Epstein-Barr

SynKIR-310 for Relapsed/Refractory B-NHL

NCT06544265

RECRUTANDO

CASPALLO: Allodepleted T Cells Transduced With Inducible Caspase 9 Suicide Gene

NCT00710892

EM ANDAMENTO

Donor Peripheral Stem Cell Transplant in Treating Patients With Advanced Hematologic Cancer or Other Disorders

NCT00544115

EM ANDAMENTO

Physician-Initiated Stop-Smoking Program for Patients Receiving Treatment for Early-Stage Cancer

NCT00002520

CONCLUÍDO

Fase II

Biological Therapy in Treating Patients at High-Risk or With Lymphoma, Lymphoproliferative Disease, or Malignancies

NCT00002663

CONCLUÍDO

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NCT00544115 · Donor Peripheral Stem Cell Transplant in Treating Patients W…Ativo

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NCT00002520 · Physician-Initiated Stop-Smoking Program for Patients Receiv…Concluído

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Publicações mais relevantes

Timeline de publicações

0 papers (10 anos)

#1

Molecular pathogenesis and evolving treatment landscape of extranodal NK/T-cell lymphoma.

Proceedings of the Japan Academy. Series B, Physical and biological sciences2026

Extranodal NK/T-cell lymphoma (ENKTL) is a rare, aggressive Epstein-Barr virus (EBV)-associated malignancy. The 5th edition of the WHO classification refined their nomenclature by removing "nasal type" and introducing related entities to reflect updated biological insights. This review synthesizes recent advances in epidemiology and molecular pathogenesis in ENKTL, highlighting recurrent driver gene alterations, particularly frequent mutations in X-linked genes such as DDX3X and MSN, alongside TP53 mutations and PD-L1 structural variations that facilitate immune evasion. We also discuss novel mouse models that replicate the ENKTL niche, revealing how Trp53 loss and the EBV oncoprotein LMP1 synergistically remodel the tumor microenvironment to promote lymphomagenesis. Therapeutically, while L-asparaginase-based regimens including SMILE and P-GemOx remain the standard of care, emerging immune checkpoint inhibitors have demonstrated encouraging efficacy, particularly in combination with chemotherapy. This review provides an integrated perspective on the evolving landscape of diagnosis, disease biology, and translational treatment strategies for NK/T-cell lymphoproliferative disorders.

#2

Epstein-Barr virus infection in children with liver transplantation.

World journal of hepatology2026 Feb 27

Epstein-Barr virus (EBV) infection commonly occurs in children, particularly in developing countries. Most children infected with EBV are asymptomatic, though some develop significant complications, including EBV-associated malignancies, hemophagocytic lymphohistiocytosis, and multiple sclerosis. In immunocompromised children, including those with liver transplantation, EBV infection manifests with a diverse spectrum of presentations, varying from asymptomatic to post-transplant lymphoproliferative disorder, which can evolve into lymphoma. Therefore, close monitoring, early detection, and prompt management are crucial. This review aimed to investigate the pathogenesis and manifestations of EBV in healthy children and those who underwent liver transplantation. The proposed algorithm for early EBV detection and management, along with case studies, is provided to help pediatricians increase their index of suspicion.

#3

Classic hodgkin lymphoma associated with Epstein-Barr virus reactivation during vedolizumab therapy for ulcerative colitis.

Clinical journal of gastroenterology2026 Feb 28

Epstein-Barr virus (EBV)-associated lymphoproliferative disorders have been reported in patients receiving immunosuppressive therapy for inflammatory bowel disease; however, the onset of classic Hodgkin lymphoma (cHL) during vedolizumab therapy is extremely rare. A 73 year-old woman with ulcerative colitis (UC) was steroid-dependent, showing disease exacerbation when prednisolone was tapered or discontinued. Azathioprine was administered eight years prior but was discontinued after a short period due to liver dysfunction. Vedolizumab was initiated 31 months before presentation. Despite initial improvements in UC with vedolizumab, hematochezia subsequently persisted. Other biologics or immunomodulators that could cause systemic immunosuppression were avoided because she was receiving treatment for breast cancer. Colonoscopy showed erosions in the transverse colon and an ulcerative lesion in the sigmoid colon. A biopsy revealed high-grade dysplasia in the transverse colon and inflammatory granulation tissue without malignancy in the sigmoid lesion; therefore, surgery was indicated. Laparoscopic total proctocolectomy was performed, and the surgical specimen contained Reed-Sternberg cells positive for CD20, CD30, PD-L1, and EBV-encoded RNA, establishing EBV-associated cHL. Although the development of cHL is likely multifactorial, clinicians should be aware that EBV-associated intestinal cHL may develop in patients with UC receiving vedolizumab when tumor-like ulcers or mural thickening are encountered.

#4

A multidimensional workflow profiling of allogeneic virus-specific T cell therapies reveals potency-linked signatures.

Nature communications2026 Jan 07

Allogeneic virus-specific T cell (VST) therapies offer distinct advantages, including scalability, rapid deployment, and manufacturing consistency, and have demonstrated efficacy in multiple clinical trials. However, identifying VST products with high therapeutic potential remains a major hurdle. Here, we present a multidimensional analytical platform that integrates in vitro and in vivo anti-viral reactivity, T cell receptor (TCR) repertoire analysis, gene expression profiling, immunophenotyping, and functional validation in a humanized mouse model. Epstein-Barr virus (EBV)-specific T cells expanded from HLA-diverse healthy donors consistently enriched for TCRs targeting EBV-encoded antigens. Transcriptomic and high-dimensional flow cytometric analyses revealed a distinct effector-associated signature. Importantly, this integrative approach uncovered correlative biomarkers of T cell potency and effector function, validated in an in vivo model of EBV-driven B cell lymphoma. These findings establish a scalable framework for the characterization of allogeneic T cell products and may inform the development of predictive metrics for in vivo efficacy.

#5

Withaferin A inhibits EBV-driven lymphomagenesis through multiple mechanisms, including EBNA1 degradation.

Blood2026 Feb 19

Epstein-Barr virus (EBV) infects over 90% of the global population and drives multiple aggressive B-cell malignancies, including Burkitt lymphoma, diffuse large B-cell lymphoma, and Hodgkin lymphoma. Standard chemoimmunotherapy regimens can be highly effective, yet Epstein-Barr virus positive (EBV+) lymphomas sometimes exhibit poorer responses, higher resistance, and worse survival compared with Epstein-Barr virus-negative (EBV-) counterparts. This reflects the virus's ability to drive immune evasion, alter cell death pathways, and exploit host immune dysfunction, underscoring the potential value of EBV-directed strategies. Withaferin A (WA), a steroidal lactone with known anticancer and anti-inflammatory properties, was evaluated for its efficacy against EBV-associated B-cell non-Hodgkin lymphomas (B-NHL). Across a panel of lymphoma cell lines, WA demonstrated selective cytotoxicity toward EBV+ B-NHL, in part through proteasome-dependent degradation of EBNA1 (EBV nuclear antigen 1) and subsequent loss of viral episomes, alongside additional effects on cellular stress and survival pathways. Mechanistic studies revealed that WA collapses antioxidant defenses, drives oxidative stress, and suppresses NF-κB signaling, creating a multipronged disruption of viral and host survival pathways. In primary B-cell models and a cord blood-humanized mouse model of EBV-driven lymphomagenesis, WA inhibited B-cell transformation, reduced splenomegaly and tumor burden, and significantly prolonged survival without evidence of increased viral replication. These findings establish WA as a potent preclinical candidate that selectively targets vulnerabilities unique to EBV-transformed B cells, supporting further optimization and evaluation for EBV+ B-cell malignancies.

Publicações recentes

[Clinical Characteristics and Prognostic Analysis of Patients with EBV-Positive Diffuse Large B-Cell Lymphoma].

Zhongguo Shi Yan Xue Ye Xue Za Zhi2026 Feb

[EBNA1 Knockdown Modulates Proliferation, Apoptosis, and Metabolism in Burkitt's Lymphoma Cells by Downregulating miR-127-5p].

Zhongguo Shi Yan Xue Ye Xue Za Zhi2026 Feb

A 43-Year-Old Man With Isolated Cutaneous Lymphomatoid Granulomatosis Presenting as a Chronic Necrotizing Ulcer of the Upper Arm.

Am J Case Rep2026 Mar 14

Composite lymphoma composed of follicular lymphoma and nodal T-follicular helper cell lymphoma: report of 3 cases highlighting histopathologic zonation of each neoplastic component.

Am J Clin Pathol2026 Mar 3

Temporal association of diffuse large B-cell lymphoma with PD-1 inhibitor therapy in a patient with gastric adenocarcinoma: a case report.

Front Immunol2026

Ver todas no PubMed

📚 EuropePMCmostrando 199

Zhongguo shi yan xue ye xue za zhi

[Clinical Characteristics and Prognostic Analysis of Patients with EBV-Positive Diffuse Large B-Cell Lymphoma].

Zhongguo shi yan xue ye xue za zhi

[EBNA1 Knockdown Modulates Proliferation, Apoptosis, and Metabolism in Burkitt's Lymphoma Cells by Downregulating miR-127-5p].

The American journal of case reports

A 43-Year-Old Man With Isolated Cutaneous Lymphomatoid Granulomatosis Presenting as a Chronic Necrotizing Ulcer of the Upper Arm.

Proceedings of the Japan Academy. Series B, Physical and biological sciences

Molecular pathogenesis and evolving treatment landscape of extranodal NK/T-cell lymphoma.

World journal of hepatology

Epstein-Barr virus infection in children with liver transplantation.

American journal of clinical pathology

Composite lymphoma composed of follicular lymphoma and nodal T-follicular helper cell lymphoma: report of 3 cases highlighting histopathologic zonation of each neoplastic component.

Temporal association of diffuse large B-cell lymphoma with PD-1 inhibitor therapy in a patient with gastric adenocarcinoma: a case report.

Clinical journal of gastroenterology

Classic hodgkin lymphoma associated with Epstein-Barr virus reactivation during vedolizumab therapy for ulcerative colitis.

Experimental biology and medicine (Maywood, N.J.)

Expression of MicroRNA-155 and its associations with EBV serological markers and inflammatory cytokines in young lymphoma patients with evidence of active EBV infection.

Infectious agents and cancer

Inhibition of death-ligand-induced apoptosis in Epstein-Barr virus-encoded small RNAs-expressing human T-cell line.

ASAIO journal (American Society for Artificial Internal Organs : 1992)

Machine Learning Models for Posttransplant Lymphoproliferative Disorder (PTLD) Risk Prediction in Thoracic Transplantation.

Open forum infectious diseases

Rapidly Expanded EBV-Specific T Cells for the Treatment of Refractory EBV Reactivation and EBV-Related Lymphoproliferative Disorders.

Hemophagocytic lymphohistiocytosis associated with extranodal NK/T cell lymphoma, nasal type or aggressive NK cell leukemia: a retrospective multicenter study of Jiangsu Cooperative Lymphoma Group (JCLG).

Pediatric lymphoproliferative disorders - Emerging insights and management: A narrative review.

Medicine

Annals of plastic surgery

Bilateral Breast Implant-Associated Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma: A Case Report and Literature Review.

Autoimmune disease-associated lymphomas: research progress and review.

Classical Hodgkin lymphoma associated with immune deficiency and dysregulation exhibits a prognosis similar to sporadic cases but with distinct predictive markers.

Journal of medical case reports

Diagnostic challenges in Burkitt's lymphoma with skull base and paravertebral involvement, and hearing loss: a case report.

Journal of pediatric hematology/oncology

Germline Homozygous RAG1 Missense Variant Associated With Epstein-Barr Virus Negative Childhood Burkitt Lymphoma: A Case Report.

Epstein-Barr Virus-Associated T/NK-Cell Neoplasms.

Long-term trends of mortality from systemic lupus erythematosus in England & Wales and the United States.

Lupus

A multidimensional workflow profiling of allogeneic virus-specific T cell therapies reveals potency-linked signatures.

Nature communications

Cancer causes & control : CCC

Higher chemical complementarity of EBV epitopes and IGH CDR3s correlates with better outcomes for lymphoma and ovarian cancer.

bioRxiv : the preprint server for biology

Dissecting Epstein-Barr Virus Dependence Across Diverse Infected Cell Models.

International journal of hematology

Mantle cell lymphoma exhibiting repeated progression with the initiation of a JAK-1 inhibitor for psoriatic arthritis.

Molecular cancer therapeutics

Vitamin C conditioning generates tumor-targeting CAR T cells with superior cytotoxicity and fitness in a post-transplant lymphoproliferative disorder tumor model.

Clinical lymphoma, myeloma & leukemia

Dismal Outcome of EBV-Positive Nodal T/NK-Cell Lymphoma: A Multicenter Retrospective Study.

Pathology, research and practice

Nodal T-follicular helper cell lymphoma with hodgkin/reed-sternberg-like cells: Clinicopathologic and molecular characterization of 11 cases.

Histological subtypes of rheumatoid arthritis-associated lymphoproliferative disorders: Serological and Epstein-Barr virus findings.

Modern rheumatology

Classic Hodgkin lymphoma in a patient with Behçet's disease: a case report and review of the literature.

Clinical rheumatology

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

Redefining the Spectrum of Epstein-Barr Virus-Positive (EBV+) Diffuse Large B-cell Lymphoma and EBV+ Classic Hodgkin Lymphoma.

Epstein-Barr virus and human MiRNAs crosstalk: orchestrating latency, lytic cycle, and immune system modulation.

Folia microbiologica

Epstein-Barr virus-associated lymphomas: biology, molecular genomics and precision oncology.

Frontiers in oncology

Castleman Disease in a Child: A Rare Cause of Persistent Cervical Lymphadenopathy.

Cureus

Current problems in pediatric and adolescent health care

Impact of infection and microbial exposures on pediatric cancer.

EBV-Positive Diffuse Large B-Cell Lymphoma (DLBCL): An Assessment and a Roadmap.

bioRxiv : the preprint server for biology

HIV-associated non-Hodgkin lymphoma tumor-microenvironment axes differ by EBV status across cellular origins.

Hematology (Amsterdam, Netherlands)

Active Epstein-Barr virus infection and its association with multiple myeloma: evidence from a meta-analytical perspective.

Epstein-barr virus-encoded small RNA incorporated prognostic model enables precision risk stratification and guides treatment decisions in peripheral t-cell lymphoma: a multicenter retrospective cohort.

Recent advances in infections as risk factors for lymphoma: a review of the effects of viral, bacterial, and fungal infections in lymphoma.

Archives of microbiology

Monocyte/macrophages may exert prominent roles in macrophage activation syndrome.

[Rinsho ketsueki] The Japanese journal of clinical hematology

[Late-onset Epstein-Barr virus-positive diffuse large B-cell lymphoma at the same site after treatment of extranodal NK/T-cell lymphoma].

Lysine-specific histone demethylase complex restricts Epstein-Barr virus lytic reactivation.

Nature microbiology

European journal of haematology

Primary Cutaneous B-Cell Lymphomas: An Updated Portrait of Classification, Biology, and Clinical Management.

Dermatologie (Heidelberg, Germany)

[Primary cutaneous B-cell lymphomas-an overview of established and novel aspects].

Epstein-Barr Virus-Positive Lymphoproliferative Disorder in an HIV Patient Successfully Treated With Rituximab.

Cureus

LMP2A-Targeting CAR-T Cells Equipped With Inducible IL-18 to Address EBV-Associated Malignancies.

HLA

Withaferin A inhibits EBV-driven lymphomagenesis through multiple mechanisms, including EBNA1 degradation.

Blood

International journal of hematology

Burkitt in disguise: clonal transformation of incidentally detected gallbladder diffuse large B-cell lymphoma in a liver transplant recipient.

Oral Plasmablastic Lymphoma: Case Series and Literature Review.

Head & neck

Primary intracranial plasmablastic lymphoma with intradural extramedullary metastasis: a case report.

BMC neurology

Exploring the Potential Association of Infectious Mononucleosis With Diffuse Large B-Cell Lymphoma: A Mendelian Randomization and miRNA Profiling Approach.

The pathogenic role and genomic characteristics of Epstein-Barr virus in vitreoretinal lymphoma.

Virologica Sinica

Environment international

Aflatoxin B1 induces subtle but coordinated histone modifications in Epstein-Barr virus infected and non-infected Burkitt lymphoma cells.

The American journal of case reports

Diagnostic Challenges in Diffuse Large B-Cell Lymphoma in a Young Liver Transplant Patient with Ulcerative Colitis: A Case Report.

Oral surgery, oral medicine, oral pathology and oral radiology

The incidence and role of EBV and HIV in head and neck lymphomas: an institutional study.

The American journal of case reports

Pediatric Liver Transplant Complications: EBV-Associated Tumors and Infection Management Strategies.

Zhonghua bing li xue za zhi = Chinese journal of pathology

[Monomorphic epitheliotropic intestinal T-cell lymphoma: a clinicopathological and genetic mutation characteristics analysis of forty-two cases].

Zhonghua bing li xue za zhi = Chinese journal of pathology

[New advances in the pathology and diagnostic challenges of extranodal NK/T-cell lymphoma].

[Rinsho ketsueki] The Japanese journal of clinical hematology

[Current status and challenges of AIDS-related malignant lymphoma].

The American Journal of dermatopathology

Methotrexate-Associated Primary Cutaneous Epstein-Barr Virus-Positive Polymorphic B-Cell Lymphoproliferative Disorder With Metachronous T-Cell Clonally Related Angioimmunoblastic T-Cell Lymphoma: A Case Report and Review of the Literature.

The clinical features and outcomes of aggressive large B cell lymphoma with concomitant hemophagocytic lymphohistiocytosis at diagnosis.

International journal of molecular sciences

CD20-Negative Large B-Cell Lymphomas: The Diagnostic Challenge of Tumors with Downregulation of Mature B-Cell Marker Expression.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

Follicular Helper T-Cell Lymphomas With Epstein-Barr Virus-Positive Neoplastic Cells: A Rare Scenario With Diagnostic Implications.

Transplantation and cellular therapy

Long-Term Efficacy of Epstein-Barr Virus-Specific T Cells for Epstein-Barr Virus-Associated Post-Transplantation Lymphoproliferative Disorder after Allogeneic Stem Cell Transplantation: A Real-World Study.

Belatacept and non-melanoma skin cancer risk in kidney transplant recipients: a narrative review from a mechanistic and clinical perspective.

BMC nephrology

Clinical and functional characterization of a novel TNFRSF9 variant causing immune dysregulation with predisposition to EBV-driven lymphomagenesis.

Internal medicine journal

Incidence and outcomes of post-transplant lymphoproliferative disorder in the Western Australian liver transplant population: a 24-year retrospective study.

Peripheral EBV antigen-specific T cell is dysfunctional in Epstein-Barr virus positive diffuse large B-cell lymphoma.

BMC cancer

Journal of clinical laboratory analysis

Clinical Significance of Plasma and Peripheral Blood Mononuclear Cell EBV-DNA in Lymphoma.

Current topics in microbiology and immunology

Primary Immunodeficiencies and EBV-Associated Diseases.

The Journal of experimental medicine

ASXL1 deficiency causes epigenetic dysfunction, combined immunodeficiency, and EBV-associated lymphoma.

Current State of AIDS-Related Malignant Lymphoma.

Clinical characteristics and prognosis of EBV-Positive mature B-Cell lymphoma in children: a retrospective study.

American journal of clinical pathology

The expanding spectrum of T-cell lymphomas with follicular helper T-cell phenotype and implications for differential diagnoses: A report of the 2023 SH/EA4HP Lymphoma Workshop.

A genome-wide association study identifies an African-specific locus on chromosome 21q22.12 associated with Burkitt lymphoma risk and survival.

Leukemia

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

Exploring the Genetic Landscape of Primary Marginal Zone Lymphoma of the Urinary Bladder.

Case Report: dose adjustment of orelabrutinib for managing central nervous system post-transplant lymphoproliferative disorder following acute lymphoblastic leukemia transplantation.

Crescentic glomerulonephritis associated with NK-large granular lymphocytic leukemia: A case report.

Medicine

Epstein-Barr virus-infected tonsillar marginal zone B cells in vivo as a precursor for immunosuppression-related B-cell lymphoma.

Journal of virology

PARP1 Inhibition Halts EBV+ Lymphoma Progression by Disrupting the EBNA2/MYC Axis.

American journal of clinical pathology

Epstein-Barr virus-positive T- and NK-cell lymphoproliferative disorders: Report from the 2023 SH/EA4HP Lymphoma Workshop.

Epstein Barr virus antibody and cancer risk in two prospective cohorts in Southern China.

Nature communications

Clinical lymphoma, myeloma & leukemia

Plasmablastic Lymphoma-A Crosstalk Between Myeloma and Lymphoma.

Scandinavian journal of immunology

TCF3 and ID3 Regulate TSPAN32 Expression in Burkitt Lymphoma.

Association of Epstein-Barr virus genomic alterations with human pathologies.

Blood

International journal of molecular sciences

High PD-L1 Expression in HRS Cells and Macrophages in Tumor Immune Microenvironment Is Associated with Adverse Outcome and EBV Positivity in Classical Hodgkin Lymphoma.

Diagnostics (Basel, Switzerland)

Protracted Tonsillitis as an Atypical Initial Manifestation of Methotrexate-Induced EBV-Positive Lymphoproliferative Disorder in Rheumatoid Arthritis: A Case Report and Literature Review.

Kaposi sarcoma-associated herpesvirus cooperates with Epstein-Barr virus to co-transform a small set of human B cells oncogenically.

Seminars in ultrasound, CT, and MR

Imaging of Immunodeficiency-Associated Lymphoproliferative Disorders.

Internal medicine (Tokyo, Japan)

Methotrexate-associated Angioimmunoblastic T-cell Lymphoma Presenting with Acute Kidney Injury.

American journal of hematology

Integrative Genomic and Transcriptomic Analysis Reveals Targetable Vulnerabilities in Angioimmunoblastic T-Cell Lymphoma.

Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology

[Methotrexate-related lymphoproliferative disease of the ileum with fistular formation between the small bowel and rectum:a case report].

Extramedullary plasmacytoma in children is a genetically distinct localized neoplasia curable by surgical resection.

Blood advances

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Tumor-Associated Sympathetic Nerves Promote the Progression of Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma.

Current topics in microbiology and immunology

Prophylactic and Therapeutic EBV Vaccination.

Efficacy and prognosis of allogeneic hematopoietic stem cell transplantation in aggressive NK-cell leukemia: a meta-analysis.

Differential expression of proliferation and immune response genes between children and adults influences survival of diffuse large B cell lymphoma.

Genetic Profiling Reveals the Distinctions Among MTX-Associated DLBCL, EBV-Positive Mucocutaneous Ulcer, and EBV + DLBCL.

Cancer science

Clinicopathological features and prognostic factors of AIDS-related lymphoma: a retrospective single-center study in China.

Cancer biomarkers : section A of Disease markers

Internalization of extracellular double-stranded DNA as a potential marker of cancer stem cells in Epstein-Barr virus-induced B-cell lymphoma.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

Epstein-Barr virus-associated infectious mononucleosis exhibits substantially higher non-treponemal test titers in biological false-positive reactions.

EBV-positive diffuse large B cell lymphoma secondary to activated phosphoinositide 3 kinase δ syndrome type 1 (APDS1): a case report and literature review.

Journal of cellular and molecular medicine

Harnessing Cellular Immunotherapy for EBV-Associated Malignancies: Current Advances and Future Directions.

Targeting intracellular LMP2 with costimulatory signal-armed antibody-like TCR T cells.

JCI insight

Epstein-Barr virus latent membrane protein 1 subverts IMPDH pathways to drive B-cell oncometabolism.

MicroRNA changes with macro potential contribute to secondary immunodeficiency in chronic lymphocytic leukemia during epstein barr virus reactivation.

STAT3, MYC, and EBNA1 cooperate through a ZC3H18 transcriptional network to regulate survival and proliferation of EBV-positive lymphomas.

DNA Methylation Epitypes of Burkitt Lymphoma with Distinct Molecular and Clinical Features.

Blood cancer discovery

Spatial transcriptomics reveals tumor microenvironment heterogeneity in EBV positive diffuse large B cell lymphoma.

Leveraging the interconnected unfolded protein response and NLRP3 inflammasome pathways to reactivate Epstein-Barr virus in diffuse large B-cell lymphomas.

NAR cancer

Integration of anti-PD-1 antibody into chemotherapeutic regimens improved the outcome of aggressive NK cell leukemia: a single-center retrospective real-world analysis.

Systemic EBV+ T-Cell Lymphoma of Childhood with Hemophagocytic Lymphohistiocytosis in a Patient with a Highly Complex Karyotype.

Genes

Annual review of immunology

Human Immune Responses to Epstein-Barr Virus Highlighted by Immunodeficiencies.

Understanding EBV infection and EBV-associated lymphomas in children.

Virology

International immunopharmacology

Long-term outcomes in patients with persistent EBV-DNA positivity after primary Epstein-Barr virus infection and clinical implications of rituximab therapy.

The American journal of tropical medicine and hygiene

Concomitant Splenic Tuberculosis and Epstein-Barr Virus-Related T-Cell Leukemia/Lymphoma in a 28-Year-Old Pregnant Woman in South Sudan.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

Cytogenomic and Clinicopathologic Comparison of MYC-Positive and MYC-Negative High-Grade B-Cell Lymphoma With 11q Aberration in the Context of Other Aggressive Lymphomas With MYC Rearrangement.

Pathology, research and practice

Fibrin-associated large B-cell lymphoma arising in a cystic lymphangiomatous lesion of the adrenal gland: A case report and overview of the entity.

Journal of cancer research and therapeutics

Plasmablastic lymphoma with cutaneous manifestations in an immunocompetent man: A rare case report with literature review.

Genes, chromosomes & cancer

Subtyping Burkitt Lymphoma by DNA Methylation.

Comparison of nanopore with illumina whole genome assemblies of the Epstein-Barr virus in Burkitt lymphoma.

Zhonghua bing li xue za zhi = Chinese journal of pathology

[Clinicopathological features and prognostic value of CD30 expression in EBV-positive diffuse large B cell lymphoma].

A patient-derived T cell lymphoma biorepository uncovers pathogenetic mechanisms and host-related therapeutic vulnerabilities.

Cell reports. Medicine

Current opinion in virology

Recent advances in animal models of lymphomagenesis caused by human γ-herpesviruses.

Pandemic-Driven Shifts in Epstein-Barr Virus (EBV) Epidemiology: Single Center Study.

Burkitt lymphoma in patients with chronic lymphocytic leukemia and other indolent B-cell lymphoid malignancies.

Leukemia & lymphoma

Prognostic impact of pre-treatment and post-treatment plasma Epstein-Barr virus DNA in peripheral T-cell lymphomas.

Annals of medicine

HIV-negative primary effusion lymphoma: a series of seven cases.

Histopathology

Turkish journal of medical sciences

Does CD47 expression have prognostic significance in classical Hodgkin lymphoma?

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Real-world evidence regarding cancer, mortality, and graft failure risk with de novo belatacept use among kidney transplant recipients in the United States.

Virchows Archiv : an international journal of pathology

Large B-cell lymphoma associated with fluid overload: two new case reports with molecular insights.

International journal of cancer

Incorporation of Epstein-Barr viral variation implicates significance of Latent Membrane Protein 1 in survival prediction and prognostic subgrouping in Burkitt lymphoma.

Development and validation of a predictive model for diagnosing EBER-positive lymphoma-associated hemophagocytic lymphohistiocytosis.

BMC cancer

Navigating Epstein-Barr Virus (EBV) and Post-Transplant Lymphoproliferative Disorder (PTLD) in Pediatric Liver Transplantation: Current Knowledge and Strategies for Treatment and Surveillance.

Genetic evidence identifies a causal relationship between EBV infection and multiple myeloma risk.

Virchows Archiv : an international journal of pathology

PD-L1/PD-L2 genetic profile in the molecular cytogenetic classification of classic Hodgkin lymphoma.

Clinical and experimental medicine

Development of a novel prognostic nomogram for AIDS-associated diffuse large B-cell lymphoma: a retrospective study from northern China.

Journal of translational medicine

Gp350-targeted CAR-T therapy in EBV-positive Burkitt lymphoma: pre-clinical development of gp350 CAR-T.

Age-related immunosenescence and Epstein-Barr virus-positive mucocutaneous ulcer presenting as oral cancer: a case report.

Frontiers in medicine

Laboratory investigation; a journal of technical methods and pathology

Epstein-Barr Virus-Encoded Latent Membrane Protein 2A Promotes Immune Escape by Upregulating SYK/Nuclear Factor-κB Signaling in Diffuse Large B-cell Lymphoma.

Differential antibody response to EBV proteome following EBVST immunotherapy in EBV-associated lymphomas.

Blood advances

Classic Hodgkin lymphoma: Pathobiological features that impact emerging therapies.

Blood reviews

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Risk and prognosis of posttransplant lymphoproliferative disease in Epstein-Barr virus-seronegative kidney transplant recipients - an observational cohort study from Norway and western Denmark.

Journal of clinical pathology

Computational pathology identifies a low B-cell content in the tumour microenvironment as a predictor of adverse outcome in patients with classic Hodgkin lymphoma treated with ABVD.

American journal of reproductive immunology (New York, N.Y. : 1989)

Better Outcomes for Ovarian Cancer Associated With the Detection of Anti-EBV TCR CDR3s: Potential Relevance to Diffuse Large B-Cell Lymphoma.

Topological importance of CD8+ T-cell enrichment in the tumor microenvironment of classic Hodgkin lymphoma.

The American journal of surgical pathology

Clinical, Pathologic, and Molecular spectrum of Angioinmmunoblastic T-cell Lymphoma Cutaneous Lesions: Clinical, Pathologic, and Molecular Analysis.

Targeted Next-Generation Sequencing of Cell-Free DNA to Detect MYC-Immunoglobulin Translocation and Epstein-Barr Virus DNA in Plasma of Burkitt Lymphoma Patients in East Africa.

JCO global oncology

The American Journal of dermatopathology

Rare Cutaneous Primary Presentation of Extracavitary Primary Effusion Lymphoma.

Pediatric allergy, immunology, and pulmonology

RASGRP1 Deficiency Associated with Diffuse Mesangial Sclerosis Infantile Nephrotic Syndrome and Epstein-Barr Virus-Induced Hodgkin's Lymphoma.

Primary thyroid B-cell lymphoma: molecular insights into its clonal evolution and relapse.

The Journal of pathology

Epstein-Barr virus-associated lymphoproliferative disease during remission after induction therapy with dasatinib in Philadelphia chromosome-positive acute lymphoblastic leukemia: a case report.

Spontaneous Regression of Plasmablastic Lymphoma Associated With Methotrexate After Withdrawal.

Journal of hematology

Role of rapidly evolving immunotherapy in chronic active Epstein-Barr virus disease.

Atypical presentations of primary lymphoproliferative processes in the central nervous system.

Radiologia

Multi-modal analysis reveals tumor and immune features distinguishing EBV-positive and EBV-negative post-transplant lymphoproliferative disorders.

Cell reports. Medicine

Transmission of an Epstein-Barr Strain Common in South-East China to a Western Individual.

Hematology. American Society of Hematology. Education Program

EBV and post-transplant lymphoproliferative disorder: a complex relationship.

Annals of diagnostic pathology

From the archives of MD Anderson Cancer Center: EBV-positive fibrin-associated large B-cell lymphoma in an ovarian leiomyoma with cystic degeneration: A case report and discussion of differential diagnosis.

Decoding Critical Targets and Signaling Pathways in EBV-Mediated Diseases Using Large Language Models.

Clinical and experimental medicine

Hodgkin lymphoma: the role of EBV plasma viral load testing in an HIV-endemic setting.

Distinct epigenetic and transcriptional profiles of Epstein-Barr virus-positive and negative primary CNS lymphomas.

Neuro-oncology

Epstein-Barr virus-associated B-cell lymphoproliferative disorders and lymphomas: Diagnostic overlaps and defining features.

Human pathology

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

Posttransplant Lymphoproliferative Disorder in Pediatric Solid-Organ Transplant Recipients: A 7-Year Single-Center Analysis.

Ubiquitin-Mediated Effects on Oncogenesis during EBV and KSHV Infection.

Genetic and immunological features of immune deficiency and dysregulation-associated lymphoproliferations and lymphomas as a basis for classification.

Histopathology

Internal medicine (Tokyo, Japan)

Lymphoproliferative Disorder in an Esophageal Cancer Patient Treated with Pembrolizumab.

The role of c-Myc in Epstein-Barr virus-associated cancers: Mechanistic insights and therapeutic implications.

Microbial pathogenesis

Methods in molecular biology (Clifton, N.J.)

B Cell Differentiation and the Origin and Pathogenesis of Human B Cell Lymphomas.

Hemophagocytic lymphohistiocytosis in a patient with Epstein-Barr virus-positive diffuse large B-cell lymphoma treated with chimeric antigen receptor T-cell therapy.

Immunotherapy

Pathobiology : journal of immunopathology, molecular and cellular biology

Nodal T-Cell Lymphoma Transdifferentiated from Mantle Cell Lymphoma with Epstein-Barr Virus Infection.

International journal of cancer

Detection of anti-EBV TCR CDR3s associated with better outcomes for EBV-positive, Ugandan cases of Burkitt lymphoma.

Fibrin associated large B-cell lymphoma accidentally identified in a breast implant capsule: a molecular report of a rare entity.

Pathologica

International journal of surgical pathology

Breast Implant-Related EBV + Diffuse Large B-Cell Lymphoma-Case Report and Review of the Literature.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Circulating Tumor DNA Sequencing for Biologic Classification and Individualized Risk Stratification in Patients With Hodgkin Lymphoma.

Journal of clinical and experimental hematopathology : JCEH

Epstein-Barr virus-positive plasmacytoma in an immunocompetent female: A case report.

Epstein-Barr virus-related lymphoproliferative disorders of the skin.

Dermatology reports

Post-transplant lymphoproliferative disorders after allogeneic hematopoietic stem cell transplantation: a case report, meta-analysis, and systematic review.

Diagnostic pathology

The DNA loop release factor WAPL suppresses Epstein-Barr virus latent membrane protein expression to maintain the highly restricted latency I program.

Adult T-cell leukemia/lymphoma with angioimmunoblastic T-cell lymphoma-like feature and molecularly confirmed RHOA Gly 17 Val (G17V) mutation: A case report.

Pathology international

Oral surgery, oral medicine, oral pathology and oral radiology

Oral manifestations of peripheral T cell lymphoma, not otherwise specified: case series and review of the current literature.

Journal of pediatric hematology/oncology

XMEN-associated Systemic EBV-positive T-cell Lymphoma of Childhood: Report of Two Cases and Literature Review.

Systemic EBV-positive T-cell lymphoma of childhood with unusual cytogenetic findings and family history of Still's disease-associated recurrent macrophage activation syndrome.

Pediatric blood & cancer

Stem cell memory EBV-specific T cells control EBV tumor growth and persist in vivo.

Science advances

Resistance mechanisms and potential therapeutic strategies in relapsed or refractory natural killer/T cell lymphoma.

Chinese medical journal

The American journal of surgical pathology

Clinicopathological and Molecular Characteristics of Rare EBV-associated Diffuse Large B-cell Lymphoma With IRF4 Rearrangement.

Mechanistic Understanding of EBV+Lymphoproliferative Disease Development After Transplantation.

Transplantation

International journal of surgical pathology

Clinicopathologic Insights and Molecular Oncogenesis: Understanding Epstein-Barr Virus-Induced B-cell Lymphoproliferations.

LMP1 enhances aerobic glycolysis in natural killer/T cell lymphoma.

Cell death & disease

Cancer imaging : the official publication of the International Cancer Imaging Society

Enhancing diagnostic precision in EBV-related HLH: a multifaceted approach using 18F-FDG PET/CT and nomogram integration.

Epstein-Barr Virus-Associated Smooth Muscle Tumor After Kidney Transplantation: A French Multicenter Retrospective Study.

Clinical transplantation

HIV infection is associated with compromised tumor microenvironment adaptive immune reactivity in Hodgkin lymphoma.

Blood advances

Enhanced prognostic evaluation of diffuse large B-cell lymphoma: A comprehensive surveillance study incorporating Epstein-Barr virus infection status and immunohistochemical markers.

Combined Flow-Fluorescence in situ hybridization to HHV-8 and EBV reveals the viral heterogeneity of primary effusion lymphoma.

Expert review of clinical immunology

Epstein-Barr virus-driven lymphoproliferation in inborn errors of immunity: a diagnostic and therapeutic challenge.

Impact of prophylaxis with rituximab on EBV-related complications after allogeneic hematopoietic cell transplantation in children.