Raras
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Nocardiose
ORPHA:31204CID-10 · A43.0CID-11 · 1C1BDOENÇA RARA

A Nocardiose é uma infecção bacteriana aguda, subaguda ou crônica, que pode ser localizada (na pele, nos pulmões, no cérebro) ou generalizada (atingindo o corpo todo).

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Introdução

O que você precisa saber de cara

📋

A Nocardiose é uma infecção bacteriana aguda, subaguda ou crônica, que pode ser localizada (na pele, nos pulmões, no cérebro) ou generalizada (atingindo o corpo todo).

Pesquisas ativas
1 ensaio
9 total registrados no ClinicalTrials.gov
Publicações científicas
2.403 artigos
Último publicado: 2026 Apr 16

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
Unknown
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Worldwide
Início
All ages
🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: A43.0
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Entender a doença

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Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🫁
Pulmão
7 sintomas
🛡️
Imunológico
4 sintomas
📏
Crescimento
3 sintomas
❤️
Coração
3 sintomas
🫃
Digestivo
2 sintomas
🧬
Pele e cabelo
2 sintomas

+ 24 sintomas em outras categorias

Características mais comuns

90%prev.
Febre
Muito frequente (99-80%)
55%prev.
Dispneia
Frequente (79-30%)
55%prev.
Dor torácica
Frequente (79-30%)
55%prev.
Escarro anormal
Frequente (79-30%)
55%prev.
Tosse produtiva
Frequente (79-30%)
55%prev.
Bacteremia
Frequente (79-30%)
52sintomas
Muito frequente (1)
Frequente (8)
Ocasional (28)
Muito raro (15)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 52 características clínicas mais associadas, ordenadas por frequência.

FebreFever
Muito frequente (99-80%)90%
DispneiaDyspnea
Frequente (79-30%)55%
Dor torácicaChest pain
Frequente (79-30%)55%
Escarro anormalAbnormal sputum
Frequente (79-30%)55%
Tosse produtivaProductive cough
Frequente (79-30%)55%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico2.403PubMed
Últimos 10 anos200publicações
Pico2025123 papers
Linha do tempo
2026Hoje · 2026🧪 2010Primeiro ensaio clínico📈 2025Ano de pico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
·Pré-clínico2
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 2 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Nocardiose

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

Pesquisa e ensaios clínicos

9 ensaios clínicos encontrados, 1 ativos.

Distribuição por fase
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
1.059 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 1.059

#1

Molecular mechanisms underlying Nocardia host interactions.

Frontiers in cellular and infection microbiology2026

Nocardia species are opportunistic pathogens that cause localized and disseminated infections, particularly in immunocompromised individuals. Despite their clinical importance, the molecular mechanisms underlying Nocardia pathogenicity remain incompletely understood. This review summarizes current advances in Nocardia virulence factors, host immune responses, and intracellular survival strategies. A diverse array of virulence factors enables Nocardia to invade host cells, circumvent immune defenses, and maintain persistence within host tissues, including mammalian cell entry (Mce) proteins, antioxidant enzymes, phospholipase C, hemolysins, and siderophore-associated proteins. Host protection against Nocardia relies primarily on innate immune responses, with neutrophils playing a central role and being coordinated by γδT cells and interleukin-17-mediated signaling pathways. In addition, the clinical epidemiology of nocardiosis and animal models of Nocardia infection are also briefly summarized. However, most mechanistic studies remain restricted to a limited number of type strains. Further investigations into Nocardia-host interactions are essential for the development of improved diagnostic, therapeutic, and preventive strategies for nocardiosis.

#2

Pulmonary infection by Nocardia saintgeorgesii mimicking lung cancer with concurrent pulmonary embolism in an immunocompetent host: a case highlighting the diagnostic role of mNGS.

Frontiers in cellular and infection microbiology2026

Pulmonary nocardiosis presents a diagnostic challenge due to its frequent mimicry of lung cancer on imaging and the low sensitivity of conventional cultures. We report a case initially misdiagnosed as malignancy in an immunocompetent host, where metagenomic next-generation sequencing (mNGS) provided a definitive diagnosis and revealed a concurrent pulmonary embolism, suggesting a potential underrecognized association. This report describes a case of PN in an immunocompetent patient who was initially misdiagnosed with lung cancer based on imaging findings but later confirmed as pulmonary nocardiosis via mNGS. Notably, the patient also developed pulmonary embolism (PE). Empirical antibiotic therapy with piperacillin-tazobactam was initiated initially, supplemented with inhaled ipratropium bromide and expectorants to alleviate symptoms. Based on imaging findings suggestive of lung cancer, an invasive procedure was scheduled. mNGS was subsequently performed for further diagnosis. The subsequent results, along with CT scans, indicated no evidence of malignancy, leading to a consideration of Nocardia infection. The treatment regimen was then adjusted to ceftriaxone sodium combined with compound sulfamethoxazole, and the surgical schedule was canceled. The patient's condition showed significant improvement, and he was discharged without fever or dyspnea. Some literature suggests that many PN patients present with concurrent deep vein thrombosis (DVT), suggesting a potential yet underrecognized association between Nocardia infection and thrombotic events. However, this correlation has not been fully reported before.

#3

Epidemiology, clinical treatment and outcomes, susceptibility patterns and genotypic analysis of 214 Nocardia strains from multiple centers in Henan Province.

Frontiers in cellular and infection microbiology2026

This study aimed to investigate the epidemiology, clinical treatment and outcomes, antimicrobial resistance profiles and genotypic analysis of 214 Nocardia strains collected from 9 hospitals in Henan Province spanning 9 years. Through retrospective analysis of hospitalized patients with nocardiosis, the epidemiological characteristics of 214 Nocardia strains were elucidated. These isolates were identified and subjected to the broth microdilution method for the antimicrobial susceptibility profiles, and the resistance and virulence genes were determined using whole-genome sequencing (WGS). Of all strains, 74.8% were collected from lower respiratory tract specimens, and N. cyriacigeorgica was the most commonly isolated species (28%), followed by N. farcinica (24.8%), N. abscessus (7.9%), N. amamiensis (7.9%), N. otitidiscaviarum (7.5%). 93.9% were obtained from in-province patients, and Nanyang City (28.0%) was with the highest isolation rate in Henan Province. Simultaneously, all of the strains were susceptible to linezolid (LZD), and 99.1% susceptible to trimethoprim-sulfamethoxazole (TMP-SMX). The antibiotic resistance profiles of other antibiotics varied tremendously among different Nocardia species. Of all the patients, 108 (50.7%) received TMP-SMX monotherapy or multidrug regimen; moreover, 182 (85.5%) patients recovered after treatment. Notably, 12 antibiotic resistance genes and 11 virulence genes were identified, implicating the complexity of resistance and pathogenicity mechanisms. Meanwhile, the MDR rates for Nocardia species ranged from 68.8% in N. otitidiscaviarum to 17.7% in N. amamiensis. No strains exhibited the XDR and PDR phenotypes. This study provides a comprehensive evaluation of the epidemiology, phenotypic and genotypic profiles, and clinical treatment of Nocardia species in Henan, China. TMP-SMX and LZD can be used respectively for the clinical routine and critical treatment of nocardiosis. Particular emphasis is placed on the fact that antibiotic resistance and pathogenicity are species - specific, therefore, the AST of Nocardia isolates should be conducted and standardized, and attempts should be made to monitor its resistance molecular mechanisms.

#4

Pulmonary nocardiosis masquerading as refractory haemoptysis in a bronchiectasis patient: the critical role of multidisciplinary management.

BMJ case reports2026 Jan 07

An immunocompetent male in his 30s with a history of bronchiectasis presented with recurrent haemoptysis (5-10 mL every 2 months) over 4 years. High-resolution CT revealed cystic bronchiectasis and ground-glass opacities. Bronchoscopy identified active bleeding from a ruptured bronchial artery, which was successfully managed with emergent embolisation. Bronchoalveolar lavage demonstrated weakly acid-fast branching filaments, later confirmed as Nocardia asteroides by matrix-assisted laser desorption-ionisation time of flight mass spectrometry. The patient responded well to trimethoprim-sulfamethoxazole and remained stable at follow-up.This case highlights three key points: (1) pulmonary nocardiosis should be considered in chronic haemoptysis, especially in patients with structural lung disease, even if immunocompetent; (2) rapid microbiological diagnosis is critical, particularly when acid-fast staining yields atypical results; and (3) bronchial artery embolisation can be lifesaving in cases of nocardial vasculitis with active bleeding. The report underscores the importance of multidisciplinary management in such complex presentations.

#5

Disseminated nocardiosis involving lung, liver, and spleen in a patient with intestinal Behçet's disease under combined immunosuppressive therapy.

Clinical journal of gastroenterology2026 Feb

We report a rare case of disseminated nocardiosis in a woman in her 50 s with a 20-year history of intestinal Behçet's disease who had been receiving infliximab, azathioprine, and oral betamethasone. She developed fever and sore throat 6 weeks after infliximab administration. Laboratory findings revealed leukocytosis, elevated liver enzymes, and markedly increased C-reactive protein and procalcitonin. Contrast-enhanced computed tomography revealed multiple nodular lesions in both lungs and multiple abscesses in the liver and spleen. Blood cultures identified Nocardia species, and a diagnosis of disseminated nocardiosis was established. Initial treatment with trimethoprim-sulfamethoxazole was discontinued because of drug-induced pancreatitis. The regimen was switched to imipenem/cilastatin, followed by minocycline, resulting in complete abscess resolution. A literature review identified three similar cases with lung, liver, and splenic abscesses, all with significant T-cell-related immunosuppression. This case highlights the risk of disseminated Nocardia infection in patients receiving combined immunosuppressive therapy, including biologics, and highlights the importance of early diagnosis and adaptable antimicrobial management in immunocompromised hosts.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC1.592 artigos no totalmostrando 200

2026

Primary cutaneous nocardiosis caused by Nocardia brasiliensis: isolation, susceptibility, and molecular identification in eight consecutive cases from a tertiary hospital.

Frontiers in medicine
2026

Disseminated nocardiosis associated with anti-GM-CSF antibodies mimicking metastatic lung cancer.

Thorax
2026

Nocardiosis: clinical and pathologic examination of 140 cases representing 18 species in 6 complexes.

American journal of clinical pathology
2026

NCY-1 β-Lactamase Activity Correlates With Antimicrobial Susceptibility of a Clinical Strain of Nocardia cyriacigeorgica.

MicrobiologyOpen
2026

Molecular mechanisms underlying Nocardia host interactions.

Frontiers in cellular and infection microbiology
2026

Elusive Diagnosis of Recurrent Subcutaneous Emphysema: Nocardia farcinica Infection in an Immunocompetent Female Patient.

Infection and drug resistance
2026

Concurrent Presentation of Nocardia abscessus Infection and Pyoderma Gangrenosum Following Trauma.

Cureus
2026

Pulmonary infection by Nocardia saintgeorgesii mimicking lung cancer with concurrent pulmonary embolism in an immunocompetent host: a case highlighting the diagnostic role of mNGS.

Frontiers in cellular and infection microbiology
2026

Redefining the diagnostic pathway for pulmonary nocardiosis: The imperative for early metagenomic sequencing.

World journal of radiology
2026

Mechanistic Analysis of Programmed Iteration by Module 5 of the Nocardiosis-Associated Polyketide (NOCAP) Synthase.

Biochemistry
2026

Nocardia Infection Complicated by Severe Hyponatremia in a Renal Transplant Patient.

Cureus
2026

Fatty acid synthase-II is required for the synthesis of mycolic acid and essential for pathogenicity of Nocardia seriolae.

Microbial pathogenesis
2026

Epidemiology, clinical treatment and outcomes, susceptibility patterns and genotypic analysis of 214 Nocardia strains from multiple centers in Henan Province.

Frontiers in cellular and infection microbiology
2026

Diagnostic value of repeat deep sampling and cytocentrifugation in disseminated nocardiosis due to Nocardia brasiliensis with intramuscular and prostatic abscesses in a patient with myelodysplastic syndrome.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
2026

Nocardia farcinica Brain Abscess Mimicking Acute Ischemic Stroke in an Immunocompetent Elderly Patient: A Case Report.

Cureus
2026

Analysis of Clinical Characteristics of 25 Patients With Pulmonary Nocardiosis Diagnosed by Next-Generation Sequencing.

Diagnostic cytopathology
2026

Synergistic and additive in vitro interactions of imipenem, trimethoprim-sulfamethoxazole, amikacin, and clofazimine against clinical isolates of Nocardia wallacei.

European journal of clinical microbiology &amp; infectious diseases : official publication of the European Society of Clinical Microbiology
2026

Endogenous Nocardia Nova Panophthalmitis Masquerading as Malignancy: A Clinicopathologic Report.

Retinal cases &amp; brief reports
2026

Multi-year population-based study of the clinical and epidemiological risk factors for mortality in nocardiosis: survival analysis from a large regional Canadian healthcare region.

BMC infectious diseases
2026

Nocardiosis in Immunocompromised Hosts: A Retrospective, Single-Center Analysis of Clinical and Microbiological Determinants of Central Nervous System Involvement.

Transplant infectious disease : an official journal of the Transplantation Society
2026

Structural and functional insights into glycosyltransferase from Nocardia asteroides NCTC11293 and structure-guided discovery of marine and phytochemical leads through pharmacokinetic screening and molecular dynamics studies.

Journal of molecular graphics &amp; modelling
2026

Case Report: Rare Presentation of Nocardia cyriacigeorgica Pleural Nocardiosis in a Kidney Transplant Patient.

Transplantation proceedings
2026

Clinical and radiographic feature of pulmonary nocardiosis: A study of 102 cases.

World journal of radiology
2026

Bilateral Nocardia farcinica Chorioretinitis With Endogenous Endophthalmitis and Concurrent CNS Disease: A Case Report.

Cureus
2025

Efficacy of a probiotic fermented herb in the prevention and treatment of fish nocardiosis.

Frontiers in veterinary science
2026

Optimizing Tedizolid Dosing in Cerebral Nocardiosis: Clinical Impact of Direct Unbound Concentration Measurement and Population PK Modelling in Two Cases.

JAC-antimicrobial resistance
2026

A Case of Disseminated Nocardiosis in an Elderly Patient Receiving Long-Term Glucocorticoid Therapy for Polymyalgia Rheumatica.

The Journal of rheumatology
2026

Disseminated Nocardia ignorata Infection with Splenic and Brain Involvement in Patient with Large B-Cell Lymphoma.

Emerging infectious diseases
2026

How we treat Nocardia infections in transplant recipients and people with HIV.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
2026

Clinical patterns, species-specific correlations, and therapeutic outcomes of nocardiosis in immunocompetent individuals: a systematic analysis based on literature.

Annals of clinical microbiology and antimicrobials
2026

Pulmonary Nocardia otitidiscaviarum in immunocompetent individuals: a case series and literature review.

BMC infectious diseases
2026

Risk Factors and Outcomes of Disseminated Nocardiosis Across Host Risk Groups.

Open forum infectious diseases
2026

Disseminated drug-resistant nocardiosis in a patient with advanced HIV.

IDCases
2026

Protective efficacy of the optimized GluB-MTAP fusion subunit vaccine against Nocardia seriolae infection in largemouth bass (Micropterus salmoides).

Fish &amp; shellfish immunology
2026

Clinical features of pulmonary nocardiosis: a descriptive research study.

BMC pulmonary medicine
2025

Pulmonary Nocardiosis in an Immunocompetent Host: A Diagnostic Challenge Requiring Multimodal Evaluation.

Cureus
2026

Pulmonary nocardiosis masquerading as refractory haemoptysis in a bronchiectasis patient: the critical role of multidisciplinary management.

BMJ case reports
2026

Bridging the gap in nocardiosis treatment: the promise of nanoparticle-based antimicrobials.

Annals of medicine and surgery (2012)
2025

Disseminated nocardiosis caused by Nocardia asteroides resistant to trimethoprim-sulfamethoxazole.

Medicina intensiva
2025

A Rare Case of Cervicofacial Nocardiosis and Associated Mandibular Osteomyelitis: Therapeutic Challenges in a Transplant Patient.

Diseases (Basel, Switzerland)
2025

Nocardia vinacea infection with septic articular involvement and tenosynovitis.

BMC infectious diseases
2025

Occult ectopic ACTH syndrome presenting with pulmonary nocardiosis and cognitive decline in a vulnerable patient.

BMJ case reports
2026

Nocardia farcinica brain abscess in an immunocompetent patient with isolated hemianopsia.

Acta clinica Belgica
2025

It never rains but pours: disseminated nocardiosis in a renal transplant patient from Nigeria - a case report.

BMC infectious diseases
2025

Hidden Within: Pulmonary Nocardiosis in an Immunocompetent COPD Patient.

Puerto Rico health sciences journal
2025

An Interesting Case of Ocular Nocardiosis Mistaken as a Fungal Corneal Ulcer.

Cureus
2026

Develop subunit vaccines against Nocardia seriolae in hybrid snakehead (Channa maculata ♀ × Channa argus ♂) using two resuscitation-promoting factors.

Fish &amp; shellfish immunology
2025

Infection with Nocardia pneumoniae in a 54-year-old woman with bronchiectasis - a case report and review of the literature.

Respiratory medicine case reports
2025

Eyelid Nocardiosis After Lower Blepharoplasty.

Ophthalmic plastic and reconstructive surgery
2025

A Rare Presentation of Synchronous Pneumocystis Pneumonia and Cutaneous Nocardiosis on 18F-FDG PET/CT.

Nuclear medicine and molecular imaging
2025

Massive hemoptysis as the sentinel symptom: a case report of pulmonary nocardiosis in an immunocompetent patient.

Frontiers in medicine
2026

Clinical characteristics and outcomes of nocardiosis: A retrospective analysis of 44 cases.

Diagnostic microbiology and infectious disease
2026

A methionine sulfoxide reductase A homolog gene(msrA1)deficiency significantly attenuates the virulence of Nocardia seriolae.

Fish &amp; shellfish immunology
2025

Antibiotic Susceptibility of Nocardia Clinical Isolates Collected from Chinese Patients - China, 2014-2024.

China CDC weekly
2025

The global epidemiology, risk factors, and mortality prediction of nocardiosis: an easily missed opportunistic infection.

Scientific reports
2025

In silico identification of novel alpha/beta hydrolase fold domain-containing protein associated with virulence and antibiotic resistance in Nocardia farcinica (Strain: JJSBBCNF_01).

Molecular diversity
2025

Nocardia farcinica Brain Abscess in a Glucocorticoid-Treated Patient with Giant-Cell Arteritis: A Case Report.

The American journal of case reports
2025

An isocitrate lyase gene-deleted strain of Nocardia seriolae in live attenuated vaccine development against fish nocardiosis.

Frontiers in veterinary science
2025

In Vitro Activity of Sulfamethoxazole-Trimethoprim, Amikacin, Oxazolidinones, Fluoroquinolones and Fidaxomicin against Isolates of Nocardia.

ACS omega
2025

Nocardiosis Unmasked: Therapeutic Challenges of Multiple Abscesses in an Immunocompromised Patient.

Neurology India
2025

Bronchoscopy-associated dissemination of pulmonary nocardiosis caused by Nocardia terpenica in an immunocompetent patient with bronchiectasis: A case report.

Medicine
2025

The first known case of Nocardia wallacei infection in Cyprus.

GMS hygiene and infection control
2026

Cell wall arabinogalactan is responsible for Fungitell cross reactivity in nocardiosis.

The Journal of biological chemistry
2025

Sporotrichosis or nocardiosis? Case report of subcutaneous tissue infection by Nocardia brasiliensis in an immunocompetent host.

Future microbiology
2025

Nocardia Infection Presented as Intramuscular Abscess in a Kidney Transplant Recipient: Case Report and Literature Review.

Case reports in nephrology
2025

Nocardiosis In Kidney Transplant Patients: Two Cases of a Rare but Life-Threatening Disease and a Narrative Review of the Medical Literature.

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia
2025

Epidemiology and Drug Resistance of Pulmonary Nocardiosis Among Tuberculosis-Suspected Patients in Guangzhou, China.

Infection and drug resistance
2025

Nitric Oxide Contributes to the Pathogenesis of Nocardia farcinica Infection in BALB/c Mice and Alveolar MH-S Macrophages.

Microorganisms
2025

Nocardia Osteomyelitis in Humans-A Narrative Review of Reported Cases, Microbiology, and Management.

Pathogens (Basel, Switzerland)
2025

Comparative genomics of Nocardia tsunamiensis IFM 10818, a new source of the antibacterial macrolide nargenicin A1.

Microbiology spectrum
2025

Nocardia in inborn errors in immunity.

Infectious diseases (London, England)
2025

Nocardia Nova bacteremia and viral pneumonia in a breast cancer patient post modified radical mastectomy: a case report.

BMC infectious diseases
2026

Formulation and Immunological Assessment of DNA Vaccines Utilising In Vivo-Induced Antigens Against Nocardia seriolae in Hybrid Snakehead (Channa maculata ♀ × Channa argus ♂).

Journal of fish diseases
2025

Nocardia infection: a rare case report of a cerebellar mass.

Frontiers in medicine
2025

Pulmonary Nocardiosis in a Patient With COPD and Bronchiectasis.

Open respiratory archives
2025

Disseminated brain Nocardia abscess with bronchial and esophageal fistulas.

IDCases
2025

Case Report: Diagnosis of Nocardia asteroides infection using metagenomic next-generation sequencing of lymph node puncture tissue.

Frontiers in medicine
2025

Case Report: Bloodstream infection with Nocardia cyriacigeorgica in a patient with diffuse large B-cell lymphoma.

Frontiers in medicine
2025

Pulmonary nocardiosis in kidney transplant recipients: A case report and analysis of 60 published cases.

IDCases
2026

Disseminated nocardiosis involving lung, liver, and spleen in a patient with intestinal Behçet's disease under combined immunosuppressive therapy.

Clinical journal of gastroenterology
2025

Study on the Nocardia seriolae Antagonistic Bacterium in the Gut Microbiota of Micropterus salmoides.

Biology
2025

Mediastinal nocardiosis causing dysphagia/odynophagia: a case report.

Indian journal of thoracic and cardiovascular surgery
2025

Co-infection of Nocardia otitidiscaviarum and Mycobacterium tuberculosis in an immunocompetent elderly patient with chronic obstructive pulmonary disease: A rare case from North India.

The Indian journal of tuberculosis
2026

Vulvar Nocardiosis in the Setting of dVIN: A High-Risk Infection.

The American Journal of dermatopathology
2025

The Balance Between Autoimmunity and Infection: A Case Report of Concomitant Pathology of Pulmonary Nocardia and Granulomatosis with Polyangiitis at Initial Presentation.

European journal of case reports in internal medicine
2025

Metagenomic next-generation sequencing for diagnosis of severe pneumonia caused by Nocardia otitidiscaviarum.

Journal of infection in developing countries
2025

Investigation of Risk Factors and Development of Clinical Prediction Model for Nocardiosis in Lung Transplant Recipients.

Infection and drug resistance
2026

Primary cutaneous nocardiosis: A systematic review.

Journal of the American Academy of Dermatology
2025

Pulmonary Nocardia farcinica Infection in a Non-immunocompromised Patient With Fibrotic Nonspecific Interstitial Pneumonia (NSIP).

Cureus
2025

Cutaneous nocardiosis in chronic renal insufficiency: Diagnostic and therapeutic considerations.

World journal of clinical cases
2025

Chronic renal insufficiency and Nocardia brasiliensis infection: A call for heightened vigilance and multidisciplinary management.

World journal of clinical cases
2025

Nocardia otitidiscaviarum meningitis in an immunocompetent patient diagnosed by metagenomic next-generation sequencing: a case report.

Frontiers in medicine
2025

Cerebral Nocardia Infections Following Lung Abscesses in a Kidney Transplant Recipient: A Case Report and Literature Review.

Transplantation proceedings
2025

Integrated subtractive genomics and inhibitor identification of novel FAD-dependent monooxygenase in Nocardia farcinica JJSBBCNF_01.

Biochemical and biophysical research communications
2025

Primary Cutaneous Nocardiosis of the Scrotum Following Presurgical Inguinal Shaving.

The American journal of tropical medicine and hygiene
2026

Relapsing Primary Cutaneous Nocardiosis in a Healthy Pediatric Patient.

Pediatric dermatology
2025

In-silico structural and functional annotation of hypothetical proteins from Nocardia asteroides NCTC11293: A computational approach for novel drug target identification and therapeutic development.

Computers in biology and medicine
2025

Cutaneous Nocardiosis in the Very Elderly: A Case of Lymphocutaneous Infection and a Literature Review of Patients Aged Over 85 Years.

Cureus
2025

[Clinical analysis of thirteen cases of pulmonary infection caused by Nocardia otitidiscaviarum].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
2025

Nocardia cyriacigeorgica in a Mallard (Anas platyrhynchos) from Arizona, USA.

Pathogens (Basel, Switzerland)
2025

Clinical Features of Pulmonary Nocardiosis and Diagnostic Value of Metagenomic Next-Generation Sequencing: A Retrospective Study.

Pathogens (Basel, Switzerland)
2025

Successful Treatment of Brain Abscess Caused by Nocardia farcinica with Combination Therapy Despite Discrepancies in In Vitro Results: A Case Report and Review of Diagnostic and Therapeutic Challenges.

Microorganisms
2025

The Diagnostic Challenges of Disseminated Nocardiosis in a Post-Renal Transplant Patient: A Case Report.

Reports (MDPI)
2025

Diagnostic model for COPD patients with nocardia infection: a study based on clinical features and risk factors.

Therapeutic advances in respiratory disease
2025

Chronic renal insufficiency complicated by skin infection with Nocardia brasiliensis: A case report.

World journal of clinical cases
2025

Disseminated nocardiosis with brain abscesses in an immunocompetent patient: a case report.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2025

Disseminated Nocardiosis in a Patient with Chronic Lymphocytic Leukemia Treated with Ibrutinib: A Case Report.

Infectious diseases &amp; clinical microbiology
2025

Pulmonary nocardiosis: Α threat in the near future for immunocompetent individuals?

Lung India : official organ of Indian Chest Society
2025

A Case of Nocardia cyriacigeorgica Infection and Literature Review.

Cureus
2025

Surface display of Nocardia seriolae HRP1 on Bacillus subtilis and its application as live vaccine for largemouth bass.

Scientific reports
2026

Immunoinformatics-Guided Whole Proteome-Based Multi-Epitope mRNA Vaccine Design Against Nocardia asteroides Using Surface Antigens-A Subtractive Proteomics and Reverse Vaccinology Approach.

Biotechnology and applied biochemistry
2025

Unmasking Pulmonary Nocardiosis in an Asthmatic Host Presenting With Chronic Cough, Pulmonary Nodularity, and Ground-Glass Opacities.

Cureus
2025

Disseminated Nocardiosis: Poorly Controlled Diabetes as an Immunocompromising State.

Cureus
2025

Diagnosis and management of cutaneous infections in immunocompromised hosts part I: cellular immunodeficiency.

Journal of the American Academy of Dermatology
2025

Case Report: Spinal cord abscess due to Nocardia farcinica presenting as longitudinally extensive transverse myelitis.

Frontiers in medicine
2025

Corrigendum to "Multiple lymph nodes enlargement and fever as main manifestations of nocardiosis in immunocompetent individuals: Two case reports" [Heliyon Volume 10, Issue 15, 15 August 2024, e35681].

Heliyon
2025

Clinical profile and outcomes of pulmonary nocardiosis in India: a systematic review of individual cases.

Le infezioni in medicina
2025

[Disseminated nocardiosis in an immunocompetent young steelworker].

Pneumologie (Stuttgart, Germany)
2025

Nocardiosis: A case series and literature review.

Biomedica : revista del Instituto Nacional de Salud
2025

Pulmonary Nocardiosis in an Immunocompetent Patient: A Case Report.

Clinical case reports
2025

SLE complicated with Nocardia farcinica bloodstream infection and disseminated nocardiosis: a case report.

BMC infectious diseases
2025

Differentiation of nodular pulmonary infections in immunocompromised patients using CT-based radiomics.

Diagnostic and interventional imaging
2025

Primary Cutaneous Nocardiosis (Lymphangitic Type) in an Immunocompetent Patient: A Case Report.

Microorganisms
2025

Simple Nephrectomy for Non-Functioning Kidney: An Institutional Experience with Non-Neoplastic and Incidentally Detected Neoplastic Lesions.

International journal of surgical pathology
2025

Premature Discontinuation of Trimethoprim/Sulfamethoxazole Prophylaxis in Abdominal Transplant Recipients: A Deeper Dive.

Transplant infectious disease : an official journal of the Transplantation Society
2025

Pulmonary nocardiosis with hilar mass misdiagnosed as lung cancer: A case report.

Medicine
2025

68Ga FAPI PET in a Renal Transplant Patient with Disseminated Nocardiosis-A Worthwhile Imaging Modality for Infection Imaging.

Nuclear medicine and molecular imaging
2025

Increased expression of the PD-1/PD-L1 regulatory axis in tissue leukocytes from experimental actinomycetoma by Nocardia brasiliensis in BALB/c mice.

Microbial pathogenesis
2025

A rare case of multiple brain abscesses caused by Nocardia abscessus co-infection with tuberculous meningitis in an immunocompetent patient.

BMC infectious diseases
2025

State-of-the-Art Review: Modern Approach to Nocardiosis-Diagnosis, Management, and Uncertainties.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2025

Executive Summary of State-of-the-Art Review: Modern Approach to Nocardiosis-Diagnosis, Management, and Uncertainties.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2025

Clival Osteomyelitis Secondary to Isolated Sphenoid Sinusitis Caused by Nocardia veterana in an Immunocompetent Patient: A Case Report.

Cureus
2025

Bifocal Nocardiosis Mimicking Neutrophilic Dermatosis in an Immunocompromised Patient.

International journal of dermatology
2025

Nocardia brasiliensis in diabetic foot abscess: A rare case report.

Journal of family medicine and primary care
2025

Case Report: Nanopore Sequencing-Based Detection of Pulmonary Nocardiosis Caused by Nocardia Otitidiscaviarum in an Immunocompetent Patient.

Infection and drug resistance
2025

Concurrent invasive disseminated Nocardia farcinica and Candida infections in a patient undergoing long-term glucocorticoid therapy for autoimmune thrombocytopenia: a case report.

BMC infectious diseases
2025

[Nocardiosis in solid organ transplant recipients: Clinical challenges].

Revue medicale suisse
2025

Disseminated Nocardiosis in Idiopathic CD4 Lymphocytopenia: A Rare Case and Literature Review.

Internal medicine (Tokyo, Japan)
2025

Nocardia species prevalent in India and their antimicrobial susceptibility profiles.

Diagnostic microbiology and infectious disease
2025

Iatrogenic Primary Hypothyroidism Associated With Sulfamethoxazole-Trimethoprim Treatment of Nocardiosis in a Cat.

Journal of veterinary internal medicine
2025

Evaluation of immunological effects of two DNA vaccines against Nocardia seriolae in hybrid snakehead.

Fish &amp; shellfish immunology
2025

Actinomycosis With Pulmonary and Hepatic Involvement: A Case Report and Clinical Insights.

Cureus
2025

Corrigendum to "Nodular-bronchiectatic pattern in pulmonary Nocardiosis: Immune status and treatment outcomes in a multicenter retrospective Study" [Respir. Med. 237 (2025) 107922].

Respiratory medicine
2025

Kimura disease with Nocardiosis in a child with a novel mutation in IL12RB1gene.

Indian journal of medical microbiology
2025

Nocardiosis in systemic lupus erythematosus patients treated with rituximab: Report of two cases and systematic review of literature.

Lupus
2025

Actinomycosis: Mimicking Malignancies in Multiple Anatomical Sites-A Three-Patient Case Series.

Medicina (Kaunas, Lithuania)
2025

Therapeutic drug monitoring of linezolid in a case of pulmonary nocardiosis: a case report.

European journal of hospital pharmacy : science and practice
2025

Construction of Heme-Binding Protein Deleted Strain and Using It as an Attenuated Vaccine Against Nocardia seriolae in Hybrid Snakehead (Channa maculata ♀ × Channa argus ♂).

Journal of fish diseases
2025

A 40-Year-Old With Prior Stem Cell Transplant for Chronic Myeloid Leukemia Presents With Dyspnea and Respiratory Failure.

Chest
2025

Fatal Empyema Thoracis Caused by Nocardia otitidiscaviarum.

Infection and drug resistance
2025

Early diagnosis of disseminated nocardiosis in a case of pyomyositis and brain abscesses exemplifies the importance of smear examination.

Journal of clinical orthopaedics and trauma
2025

Successful maintenance therapy with moxifloxacin for disseminated nocardiosis caused by Nocardia farcinica in a patient with Cushing's syndrome.

Diagnostic microbiology and infectious disease
2025

Commentary on "Combination treatment with photodynamic therapy and antibiotic in refractory cutaneous nocardiosis: A case report".

Photodiagnosis and photodynamic therapy
2024

Nocardiosis in Renal Allograft Recipients.

Journal of global infectious diseases
2025

Evaluating the clinical utility of Aspergillus, Mucorales, and Nocardia bronchoalveolar PCRs for the diagnosis of invasive pulmonary infections in patients with hematological malignancies.

Journal of clinical microbiology
2024

Actinomycosis masquerading as a nasal polyp - a rare entity and diagnostic challenge.

GMS hygiene and infection control
2025

Central Nervous System Infections in Recipients of Solid Organ Transplant.

Transplantation proceedings
2025

Nocardiosis in domestic ferrets (Mustela putorius furo).

Journal of comparative pathology
2025

Spontaneous remission of Pneumocystis jirovecii pneumonia followed by severe pulmonary nocardiosis in a patient with HIV infection: A case report.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
2024

Sporotrichoid Nocardiosis in an Immunocompetent Patient: A Case Report.

Cureus
2025

Triple-drug antibiotic therapy for disseminated nocardial abscess in the mediastinum and brain of an immunocompetent patient: a case report.

BMC infectious diseases
2024

Infections in Kidney Transplant Recipients: Perspectives in French Caribbean.

Microorganisms
2025

Disseminated nocardiosis in a patient with AIDS and B-cell non-Hodgkin's lymphoma: a case report.

BMC infectious diseases
2025

Update on actinomycetoma treatment: linezolid in the treatment of actinomycetomas due to Nocardia spp and Actinomadura madurae resistant to conventional treatments.

Expert review of anti-infective therapy
2025

Nodular-bronchiectatic pattern in pulmonary nocardiosis: Immune status and treatment outcomes in a multicenter retrospective study.

Respiratory medicine
2024

Integrated analysis of proteome and transcriptome revealed changes in multiple signaling pathways involved in immunity in the northern snakehead (Channa argus) during Nocardia seriolae infection.

Frontiers in cellular and infection microbiology
2025

Evaluation of the Incidence of Nocardia Infection in Solid Organ Transplant Recipients on Trimethoprim-Sulfamethoxazole for Opportunistic Infection Prophylaxis.

The Annals of pharmacotherapy
2024

Brain abscesses in an immunocompromised patient with a soft tissue mass.

Southern African journal of infectious diseases
2024

A rare case of cerebellar abscess caused by Nocardia cyriacigeorgica.

Surgical neurology international
2025

Tumor mimicking cervicocranial actinomycosis with intracranial extension- a diagnosic dillema-first case report in somalia.

Radiology case reports
2024

Nocardia farcinica pneumonia complicated by pneumocystis jiroveci infection in children with Neuromyelitis Optica Spectrum Disorders: a case report and literature review.

Italian journal of pediatrics
2024

Application of bronchoalveolar lavage fluid cytomorphology in diagnosing Nocardia otitidiscaviarum: a case report.

Journal of medical case reports
2025

Shorter vs. standard-duration antibiotic therapy for nocardiosis: a multi-center retrospective cohort study.

Infection
2025

Tight muscle abscess due to Nocardia paucivorans/brevicatena complex.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
2025

Combination treatment with photodynamic therapy and antibiotic in refractory cutaneous nocardiosis: A case report.

Photodiagnosis and photodynamic therapy
2025

Amoeba plate test with Acanthamoeba castellanii as an innovative tool for Nocardia recovery from sputum samples: a proof-of-concept study.

Microbiology spectrum
2024

Case report: Metagenomic next-generation sequencing for the diagnosis of rare Nocardia aobensis infection in a patient with immune thrombocytopenia.

Frontiers in medicine
2024

Nocardia wallacei: A rare cause of actinomycetoma in an immunocompetent patient.

European journal of microbiology &amp; immunology
2024

Musculoskeletal infections associated with Nocardia species: a case series.

Journal of bone and joint infection
2024

Pulmonary Nocardiosis in a Non-Small Cell Lung Cancer Patient Being Treated for Pembrolizumab-Associated Pneumonitis.

Case reports in oncology
2024

Invasive Tracheobronchial Aspergillosis: A Fatal Complication in a Patient With Treated Mediastinal Lung Adenocarcinoma.

Cureus
2024

Neglected Pulmonary Infection Caused by Exophiala dermatitidis Misidentified as Rhodotorula spp.

Mycoses
2024

Characterization of the Flavin-Dependent Monooxygenase Involved in the Biosynthesis of the Nocardiosis-Associated Polyketide†.

Biochemistry
2024

Myasthenia gravis complicated with pulmonary infection by Nocardia cyriacigeorgica: a case report and literature review.

Frontiers in medicine
2025

Intra-abdominal nocardiosis and scedosporiosis in a dog: case report and literature review.

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
2025

Retroperitoneal granuloma in a cat caused by Nocardia brasiliensis resulting in bilateral ureteral entrapment and unilateral hydronephrosis.

Australian veterinary journal
2024

Clinical hypothyroidism in a cat associated with sulfonamide administration for the management of intracranial nocardiosis.

Australian veterinary journal
2024

Primary Cutaneous Nocardiosis.

JAMA dermatology
2024

Draft genome sequence of Nocardia sp. strain JMUB6875 isolated from a patient with disseminated nocardiosis.

Microbiology resource announcements
2024

Clinical characteristics and outcome analysis of pulmonary nocardiosis in southern China: a two-center retrospective study.

BMC infectious diseases
2024

Recurrent pulmonary nocardiosis due to Nocardia Otitidiscaviarum in a patient with isolated CD4 lymphocytopenia: a case report.

BMC infectious diseases
2024

Exposing the Masquerade of Nocardia otitidiscaviarum Pneumonia: A Case Report.

Cureus
2024

Application of MALDI-TOF mass spectrometry for identification of Nocardia species.

BMC microbiology
2024

A 13- year- old patient with acute cerebral nocardiosis: Case report and review.

Przeglad epidemiologiczny
2025

Nocardiosis in a Patient with Nephrotic Syndrome Treated with Glucocorticoids and Tacrolimus.

Internal medicine (Tokyo, Japan)
2024

Unveiling the Complexity of Nocardia Septic Arthritis in an Immunocompromised Patient: A Case Report.

HCA healthcare journal of medicine
2024

Pulmonary Nocardiosis in Renal Transplant Recipients From Pakistan: Risk Factors, Clinical Presentation, and Mortality.

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation
2024

Nocardial epidural abscess: A case report.

Interventional pain medicine
2024

Pulmonary Nocardiosis Caused by Nocardia sputorum Identified via 16S rRNA Gene Sequencing: A Case Report.

Cureus
2024

Suppurative Thyroiditis: Coinfection by Nocardia spp. and Mycobacterium tuberculosis in an Immunocompromised Patient.

Cureus
Ver todos os 1.592 no EuropePMC

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Doenças relacionadas

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Molecular mechanisms underlying Nocardia host interactions.
    Frontiers in cellular and infection microbiology· 2026· PMID 41859465mais citado
  2. Pulmonary infection by Nocardia saintgeorgesii mimicking lung cancer with concurrent pulmonary embolism in an immunocompetent host: a case highlighting the diagnostic role of mNGS.
    Frontiers in cellular and infection microbiology· 2026· PMID 41822328mais citado
  3. Epidemiology, clinical treatment and outcomes, susceptibility patterns and genotypic analysis of 214 Nocardia strains from multiple centers in Henan Province.
    Frontiers in cellular and infection microbiology· 2026· PMID 41769349mais citado
  4. Pulmonary nocardiosis masquerading as refractory haemoptysis in a bronchiectasis patient: the critical role of multidisciplinary management.
    BMJ case reports· 2026· PMID 41500713mais citado
  5. Disseminated nocardiosis involving lung, liver, and spleen in a patient with intestinal Beh&#xe7;et's disease under combined immunosuppressive therapy.
    Clinical journal of gastroenterology· 2026· PMID 41014470mais citado
  6. Nocardia asiatica Lymphadenitis in a Lung Transplant Recipient Following Travel.
    Am J Trop Med Hyg· 2026· PMID 41990737recente
  7. Imaging characteristics, yield of computed tomography, and clinical outcomes of central nervous system nocardiosis.
    Infection· 2026· PMID 41979781recente
  8. A Case Report of a Forehead Abscess Caused by Nocardia concava in a Patient with AIDS.
    J Vis Exp· 2026· PMID 41973623recente
  9. Dormant cutaneous nocardiosis presenting as a nonhealing wound following laser treatment of a traumatic scar.
    JAAD Case Rep· 2026· PMID 41972097recente
  10. Research progress on clinical challenges and prevention strategies of drug-resistant Nocardia infections.
    Front Public Health· 2026· PMID 41938978recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:31204(Orphanet)
  2. MONDO:0017776(MONDO)
  3. GARD:7210(GARD (NIH))
  4. Busca completa no PubMed(PubMed)
  5. Artigo Wikipedia(Wikipedia)
  6. Q1856914(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Nocardiose
Compêndio · Raras BR

Nocardiose

ORPHA:31204 · MONDO:0017776
Prevalência
Unknown
Herança
Not applicable
CID-10
A43.0 · Nocardiose pulmonar
CID-11
Ensaios
1 ativos
Início
All ages
Prevalência
0.0 (Worldwide)
MedGen
UMLS
C0028242
EuropePMC
Wikidata
Wikipedia
Papers 10a
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